## Sat Jan  4 01:23:56 2025
## emapper-2.1.12
## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA629394/SRR11734623/SRR11734623_p_cluster_rep_seq.fasta --output PRJNA629394_SRR11734623 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
k59_311137_1	43989.cce_4051	4.23e-22	99.8	COG1696@1|root,COG1696@2|Bacteria,1G195@1117|Cyanobacteria,3KHJQ@43988|Cyanothece	1117|Cyanobacteria	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
k59_82316_1	338963.Pcar_1385	4.16e-60	197.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_221583_1	292805.Wbm0740	1.13e-16	78.6	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,47EX5@766|Rickettsiales	766|Rickettsiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_221583_2	1236908.wNo_04220	8.05e-186	517.0	COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,47F1N@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
k59_22174_1	1236908.wNo_10700	4.35e-267	732.0	COG1409@1|root,COG1409@2|Bacteria,1R8W7@1224|Proteobacteria,2U64B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_311154_1	891968.Anamo_0842	2.26e-69	229.0	COG0556@1|root,COG0556@2|Bacteria,3TA02@508458|Synergistetes	508458|Synergistetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_2041_1	1123072.AUDH01000001_gene2822	1.56e-90	278.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JRBE@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_261694_1	330214.NIDE0357	3.47e-52	177.0	COG3034@1|root,COG3034@2|Bacteria,3J19Y@40117|Nitrospirae	40117|Nitrospirae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
k59_271676_1	7668.SPU_008424-tr	9.92e-35	139.0	COG2801@1|root,KOG0017@2759|Eukaryota,3A4CN@33154|Opisthokonta,3BRMP@33208|Metazoa,3D9YY@33213|Bilateria	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_151651_1	1229909.NSED_08955	4.58e-108	317.0	COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_52148_2	436308.Nmar_0038	2.5e-106	309.0	COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
k59_52148_3	436308.Nmar_0037	8.26e-39	136.0	COG0602@1|root,arCOG02173@2157|Archaea,41SGM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Radical_SAM
k59_101653_1	1131266.ARWQ01000012_gene1620	1.04e-17	80.9	COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
k59_101653_2	436308.Nmar_0382	5.28e-65	204.0	COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_301120_2	1173024.KI912148_gene4215	2.28e-30	119.0	COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1JJJQ@1189|Stigonemataceae	2|Bacteria	L	Transposase DDE domain	-	-	-	ko:K07487	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1_6,DUF772
k59_171996_2	330214.NIDE3327	7.75e-41	137.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
k59_251611_1	7029.ACYPI062894-PA	5.94e-21	97.4	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_241115_1	96561.Dole_2296	1.32e-67	213.0	COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,43BRN@68525|delta/epsilon subdivisions,2X72H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_221615_1	204773.HEAR0343	1.66e-91	278.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,472FC@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_2064_1	4081.Solyc09g056150.1.1	4.53e-28	125.0	COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta,44UC5@71274|asterids	35493|Streptophyta	L	Mitochondrial protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve,zf-CCHC
k59_132251_1	1454004.AW11_02365	1.15e-97	300.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_71586_1	7029.ACYPI49124-PA	3.1e-17	92.4	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQFK@50557|Insecta,3EEB6@33342|Paraneoptera	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_32397_1	7029.ACYPI071509-PA	5.12e-48	186.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,42AN1@6656|Arthropoda	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_241129_1	1121035.AUCH01000001_gene2081	8.4e-58	186.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,2KUDT@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	fnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k59_271720_1	69319.XP_008553167.1	6.48e-09	63.2	2CWTA@1|root,2RV75@2759|Eukaryota,38WQJ@33154|Opisthokonta,3C6CU@33208|Metazoa,3DME6@33213|Bilateria,42CM4@6656|Arthropoda,3SY8M@50557|Insecta,46MJ3@7399|Hymenoptera	69319.XP_008553167.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_211719_1	1236908.wNo_06480	3.92e-204	593.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,47F1J@766|Rickettsiales	766|Rickettsiales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_172020_2	515635.Dtur_0300	2.15e-21	97.1	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_251633_1	484770.UFO1_0077	1.69e-21	100.0	COG2931@1|root,COG2931@2|Bacteria,1U2V0@1239|Firmicutes,4H5TB@909932|Negativicutes	909932|Negativicutes	OQ	Haemolysin-type calcium binding protein related domain	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
k59_141987_2	671143.DAMO_0878	2.95e-30	109.0	COG5470@1|root,COG5470@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
k59_291646_1	1459636.NTE_01052	4.04e-08	53.9	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
k59_311207_1	397287.C807_00833	0.000203	43.9	COG3757@1|root,COG3757@2|Bacteria,1V127@1239|Firmicutes,25BFX@186801|Clostridia,27TX1@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
k59_311207_2	570417.WP0385	6.47e-285	780.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,47F3Y@766|Rickettsiales	766|Rickettsiales	EGP	Major facilitator	proP6	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
k59_311207_3	1236908.wNo_10010	1.69e-37	133.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,47F9J@766|Rickettsiales	766|Rickettsiales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_251654_1	330214.NIDE2442	3.28e-66	215.0	COG0281@1|root,COG0281@2|Bacteria,3J0WV@40117|Nitrospirae	40117|Nitrospirae	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
k59_201913_1	7029.ACYPI47906-PA	5.5e-59	204.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_12249_1	1131266.ARWQ01000006_gene281	9.44e-12	65.5	COG1651@1|root,arCOG02868@2157|Archaea,41T1M@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_62167_1	570417.WP0097	1.56e-191	554.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,47ETH@766|Rickettsiales	766|Rickettsiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_71621_1	1041930.Mtc_0621	1.29e-53	181.0	arCOG02754@1|root,arCOG10890@1|root,arCOG02754@2157|Archaea,arCOG10890@2157|Archaea,2Y0JM@28890|Euryarchaeota	28890|Euryarchaeota	L	SPTR Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_12252_1	570417.WP0551	2.95e-192	542.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,47F37@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_172074_1	1168065.DOK_17200	6.53e-15	80.9	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1J5ED@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	COG1109 Phosphomannomutase	algC	GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_201930_1	1336803.PHEL49_2148	5.52e-73	229.0	COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HXDJ@117743|Flavobacteriia,3VWSQ@52959|Polaribacter	976|Bacteroidetes	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
k59_52254_2	90814.KL370891_gene747	3.45e-34	120.0	2BZMS@1|root,32Z9B@2|Bacteria,1NCFD@1224|Proteobacteria,1SPFN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
k59_132322_1	1236908.wNo_07810	7.78e-61	192.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,47F58@766|Rickettsiales	766|Rickettsiales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
k59_132322_2	1236908.wNo_07800	9.55e-132	377.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,47F9G@766|Rickettsiales	766|Rickettsiales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
k59_22276_1	7176.CPIJ000788-PA	9.63e-76	258.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa,3CW1H@33213|Bilateria,41VA9@6656|Arthropoda,3SKNK@50557|Insecta,44XMA@7147|Diptera,45CTQ@7148|Nematocera	33208|Metazoa	S	O-linked n-acetylglucosamine transferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1736,PMT_2,TPR_1,TPR_10,TPR_11,TPR_12,TPR_16,TPR_2,TPR_4,TPR_7,TPR_8
k59_251681_1	570417.WP0658	4.07e-171	508.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,47EWP@766|Rickettsiales	766|Rickettsiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_311251_1	44689.DDB0216547	4.88e-16	84.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	2.7.6.2,3.6.4.13	ko:K00949,ko:K12598	ko00730,ko01100,ko03018,map00730,map01100,map03018	M00393	R00619	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03019,ko03041	-	-	-	RVT_1,zf-RVT
k59_271786_1	436308.Nmar_0011	1.44e-78	254.0	COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_2133_1	1198452.Jab_1c07180	1.15e-36	125.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,474C4@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
k59_2133_2	864051.BurJ1DRAFT_0365	3.77e-152	436.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,1KJXX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_112102_1	402626.Rpic_1128	4.8e-25	103.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_112102_2	365044.Pnap_0869	1.46e-36	135.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_291702_1	7159.AAEL006324-PA	1.74e-14	72.4	2E0WI@1|root,2S89W@2759|Eukaryota,397E2@33154|Opisthokonta,3CBQ5@33208|Metazoa,3DSZQ@33213|Bilateria,424KF@6656|Arthropoda,3STV6@50557|Insecta,45B4K@7147|Diptera,45KZ8@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_231313_1	7029.ACYPI066987-PA	6.71e-49	178.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,4225E@6656|Arthropoda,3SQX6@50557|Insecta,3ECZ1@33342|Paraneoptera	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_63397_1	7070.TC004227-PA	1.07e-68	240.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_83737_1	1236908.wNo_06740	2.81e-115	332.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,47FFT@766|Rickettsiales	766|Rickettsiales	L	ATPase involved in DNA replication initiation	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
k59_242040_1	1236908.wNo_02730	1.05e-118	349.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,47F36@766|Rickettsiales	766|Rickettsiales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_300105_1	10224.XP_006825930.1	3.4e-34	140.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_140684_1	1236908.wNo_07660	2.09e-107	324.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,47EU9@766|Rickettsiales	766|Rickettsiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_300124_1	570417.WP0095	1.61e-251	694.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2U4CI@28211|Alphaproteobacteria,47FEW@766|Rickettsiales	766|Rickettsiales	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
k59_280228_1	365044.Pnap_1017	5.58e-74	235.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4AB79@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_91025_1	436308.Nmar_1286	5.73e-101	303.0	COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_220442_1	1236908.wNo_09280	4.21e-136	389.0	COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,2TVXP@28211|Alphaproteobacteria,47FCA@766|Rickettsiales	766|Rickettsiales	P	cation ABC transporter, periplasmic cation-binding protein	znuA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_11049_1	1229909.NSED_00890	1.25e-79	242.0	COG2078@1|root,arCOG01336@2157|Archaea,41SMG@651137|Thaumarchaeota	651137|Thaumarchaeota	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
k59_260478_1	7029.ACYPI50162-PA	5.97e-31	125.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_1019_1	1229909.NSED_09690	8.12e-105	323.0	COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_81060_1	582899.Hden_0688	7.84e-34	118.0	COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,2UB97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_81060_2	582899.Hden_0689	3.97e-75	229.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_91042_1	1236908.wNo_03240	3.86e-196	573.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,47EW6@766|Rickettsiales	766|Rickettsiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_150606_1	1038859.AXAU01000026_gene2330	2.18e-105	321.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_60969_1	7029.ACYPI27720-PA	1.28e-47	177.0	KOG1075@1|root,KOG4205@1|root,KOG1075@2759|Eukaryota,KOG4205@2759|Eukaryota,3AMG2@33154|Opisthokonta,3C09Q@33208|Metazoa,3DGSX@33213|Bilateria,41TX7@6656|Arthropoda,3SFZZ@50557|Insecta,3E9XK@33342|Paraneoptera	2759|Eukaryota	A	RNA recognition motif	-	GO:0000375,GO:0000377,GO:0000398,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006366,GO:0006396,GO:0006397,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0008380,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009299,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0010638,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031974,GO:0031981,GO:0032204,GO:0032206,GO:0032268,GO:0032270,GO:0032501,GO:0032774,GO:0032991,GO:0033043,GO:0033044,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0042162,GO:0042752,GO:0042789,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043487,GO:0043488,GO:0043565,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045893,GO:0045935,GO:0046483,GO:0046700,GO:0048511,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051054,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051338,GO:0051347,GO:0051972,GO:0051973,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097167,GO:0097659,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902680,GO:1903311,GO:1903506,GO:1903508,GO:1904353,GO:1904355,GO:1905661,GO:1905663,GO:1990904,GO:2000112,GO:2000278,GO:2000573,GO:2001141,GO:2001252	-	ko:K03102,ko:K14411,ko:K15502	ko03015,ko04320,map03015,map04320	-	-	-	ko00000,ko00001,ko01009,ko03019,ko03041,ko03400	-	-	-	Ank_2,Ank_4,OST-HTH,RRM_1,RVT_1
k59_180657_1	436308.Nmar_1569	2.25e-95	292.0	COG0516@1|root,arCOG00612@2157|Archaea,41S7R@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_120857_1	436308.Nmar_0831	4.21e-120	352.0	COG0057@1|root,arCOG00493@2157|Archaea,41SDF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_240241_1	1217705.F900_02100	2.16e-19	94.0	COG3209@1|root,COG3209@2|Bacteria,1QQQ8@1224|Proteobacteria,1RTCI@1236|Gammaproteobacteria,3NSJ8@468|Moraxellaceae	1236|Gammaproteobacteria	M	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k59_81090_1	7070.TC016101-PA	1.04e-53	191.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQX5@50557|Insecta	33208|Metazoa	C	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.2.29	ko:K15407	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_100725_1	570417.WP1381	1.36e-92	277.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,47FA7@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_100725_2	163164.WD_1317	2.02e-29	107.0	COG0858@1|root,COG0858@2|Bacteria	2|Bacteria	J	rRNA processing	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_110909_1	1121468.AUBR01000073_gene1018	1.18e-48	167.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_91081_1	570417.WP0927	8.86e-156	441.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,47F76@766|Rickettsiales	766|Rickettsiales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
k59_41070_1	641112.ACOK01000028_gene834	1.62e-07	52.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_220499_1	1131266.ARWQ01000005_gene840	1.05e-83	259.0	COG0541@1|root,arCOG01228@2157|Archaea,41SDP@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_120879_1	570417.WP0512	1.79e-93	290.0	COG1305@1|root,COG1305@2|Bacteria,1R5Q7@1224|Proteobacteria,2TV5A@28211|Alphaproteobacteria,47EYX@766|Rickettsiales	766|Rickettsiales	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857
k59_250442_2	7159.AAEL005927-PA	8.12e-26	110.0	COG0277@1|root,KOG1232@2759|Eukaryota,38DBR@33154|Opisthokonta,3BFC0@33208|Metazoa,3CYB0@33213|Bilateria,41UEM@6656|Arthropoda,3SIVX@50557|Insecta,44XUX@7147|Diptera,45BKW@7148|Nematocera	33208|Metazoa	C	D-lactate dehydrognease 2	D2HGDH	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006089,GO:0006091,GO:0006103,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010042,GO:0010043,GO:0015980,GO:0016491,GO:0016614,GO:0016898,GO:0019516,GO:0019538,GO:0019752,GO:0022900,GO:0022904,GO:0031974,GO:0032025,GO:0032787,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051990,GO:0055114,GO:0070013,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901615	1.1.99.39	ko:K18204	-	-	-	-	ko00000,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
k59_300172_1	7668.SPU_022828-tr	6.37e-12	73.2	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_270483_1	7029.ACYPI061095-PA	5.57e-37	137.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_250446_1	1144342.PMI40_00339	1.56e-84	275.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,4735C@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
k59_31153_1	196367.JNFG01000209_gene256	3.32e-55	189.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_120888_1	570417.WP0572	2.83e-288	805.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,47EV7@766|Rickettsiales	766|Rickettsiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_270488_1	7070.TC011220-PA	1.73e-59	210.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_11110_1	570417.WP0195	8.13e-192	543.0	COG0484@1|root,COG0666@1|root,COG0484@2|Bacteria,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	GO:0003674,GO:0003824,GO:0005575,GO:0008150,GO:0009405,GO:0016740,GO:0016772,GO:0016773,GO:0018995,GO:0030430,GO:0033643,GO:0033646,GO:0043087,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044419,GO:0044605,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	Ank_2,Ank_4,DnaJ,DnaJ_C,TPR_8
k59_11110_2	1236908.wNo_09680	6.14e-59	183.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria	1224|Proteobacteria	T	dnak suppressor protein	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_81129_1	522306.CAP2UW1_3156	1.31e-87	268.0	COG1609@1|root,COG1609@2|Bacteria,1R5GE@1224|Proteobacteria,2VVBU@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_210590_1	570417.WP0603	1.41e-127	384.0	COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,47F23@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	virB4-1	-	-	ko:K03199	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagE_TrbE_VirB
k59_131005_1	639283.Snov_0796	3.59e-61	200.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,3F0UB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	dppF	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678	-	ko:K12372	ko02010,map02010	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_210592_1	7176.CPIJ018804-PA	1.02e-57	201.0	2D3G7@1|root,2SRFN@2759|Eukaryota,3AMW9@33154|Opisthokonta,3C1BW@33208|Metazoa,3DKZ9@33213|Bilateria,427A2@6656|Arthropoda,3SRHH@50557|Insecta	33208|Metazoa	S	Retrotransposon gag protein	-	-	-	-	-	-	-	-	-	-	-	-	Retrotrans_gag
k59_260558_1	7176.CPIJ013371-PA	3.29e-110	358.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda,3SP5N@50557|Insecta,455R4@7147|Diptera,45DRP@7148|Nematocera	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_160955_1	13037.EHJ73416	3.46e-44	182.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,41V5R@6656|Arthropoda,3SINZ@50557|Insecta	33208|Metazoa	S	RNase H	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_120907_1	945713.IALB_2101	1.74e-20	89.4	COG0074@1|root,COG0074@2|Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
k59_120907_2	439481.Aboo_0835	2.49e-15	80.5	COG1814@1|root,arCOG01096@2157|Archaea,2XWEX@28890|Euryarchaeota,3F32X@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
k59_81155_1	215803.DB30_6353	1.95e-08	61.2	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,TSP_3
k59_70704_1	1502851.FG93_03144	2.81e-71	224.0	COG0491@1|root,COG0491@2|Bacteria,1PPPW@1224|Proteobacteria,2U30I@28211|Alphaproteobacteria,3JX0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_41138_1	436308.Nmar_0179	4.95e-14	65.9	arCOG08823@1|root,arCOG08823@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_41138_2	1229909.NSED_00375	3.02e-67	209.0	COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k59_81160_1	1123325.JHUV01000010_gene1157	1.73e-22	100.0	COG0621@1|root,COG0621@2|Bacteria,2G3NZ@200783|Aquificae	200783|Aquificae	J	SMART Elongator protein 3 MiaB NifB	-	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_280332_1	1236908.wNo_01570	6.74e-150	433.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria,47F5P@766|Rickettsiales	766|Rickettsiales	NU	Bacterial type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N_2
k59_41144_1	7176.CPIJ014372-PA	4.9e-28	115.0	COG5117@1|root,KOG2153@2759|Eukaryota,38C9J@33154|Opisthokonta,3BF7I@33208|Metazoa,3CUVW@33213|Bilateria,41XGK@6656|Arthropoda,3SI20@50557|Insecta,4507V@7147|Diptera,45J6Q@7148|Nematocera	33208|Metazoa	JU	CBF/Mak21 family	NOC3L	GO:0000981,GO:0003674,GO:0003682,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006355,GO:0006357,GO:0007275,GO:0007517,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016604,GO:0016607,GO:0019216,GO:0019219,GO:0019222,GO:0030154,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045444,GO:0048513,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061061,GO:0065007,GO:0070013,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K14834	-	-	-	-	ko00000,ko03009	-	-	-	CBF,NOC3p
k59_51076_1	292415.Tbd_0131	4.27e-66	224.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1KS70@119069|Hydrogenophilales	119069|Hydrogenophilales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_132346_1	1122611.KB903983_gene3507	3.24e-123	375.0	COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4EIWP@85012|Streptosporangiales	201174|Actinobacteria	C	Molydopterin dinucleotide binding domain	fdhF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2900c	Molybdopterin,Molydop_binding
k59_52278_1	7029.ACYPI004323-PA	1.17e-55	198.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_101761_1	593117.TGAM_0982	3.14e-08	60.1	COG5306@1|root,arCOG03264@1|root,arCOG06661@1|root,arCOG03264@2157|Archaea,arCOG03512@2157|Archaea,arCOG06661@2157|Archaea	2157|Archaea	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2341,DUF5122,Laminin_G_3,PEGA
k59_241198_1	570417.WP0474	1.46e-91	274.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,47F8J@766|Rickettsiales	766|Rickettsiales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_22316_1	7159.AAEL017470-PA	4.03e-50	179.0	COG0515@1|root,KOG1152@2759|Eukaryota,38BA6@33154|Opisthokonta,3BC21@33208|Metazoa,3CVIZ@33213|Bilateria,41VZ3@6656|Arthropoda,3SKMJ@50557|Insecta,44ZXN@7147|Diptera,45CCP@7148|Nematocera	33208|Metazoa	T	Serine/Threonine protein kinases, catalytic domain	PASK	GO:0002791,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006417,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010675,GO:0010677,GO:0010817,GO:0010906,GO:0010962,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019222,GO:0019538,GO:0023051,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032270,GO:0032501,GO:0032879,GO:0032881,GO:0032885,GO:0034248,GO:0034250,GO:0035091,GO:0036211,GO:0042592,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043255,GO:0043412,GO:0043467,GO:0043576,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045727,GO:0045912,GO:0046777,GO:0046883,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048871,GO:0050789,GO:0050794,GO:0051046,GO:0051049,GO:0051171,GO:0051173,GO:0051239,GO:0051246,GO:0051247,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070092,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090087,GO:0090276,GO:0097009,GO:0140096,GO:1901564,GO:1903530,GO:2000112,GO:2000113	2.7.11.1	ko:K08801	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PAS_9,Pkinase
k59_151795_1	1348657.M622_16840	2.9e-13	66.2	COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,2KWYZ@206389|Rhodocyclales	206389|Rhodocyclales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_151795_2	1163617.SCD_n01961	2.58e-45	157.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria	28216|Betaproteobacteria	M	heptosyltransferase II	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
k59_82529_1	1236908.wNo_01960	6.22e-35	125.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,47F8R@766|Rickettsiales	766|Rickettsiales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k59_82529_2	1236908.wNo_01970	7.87e-104	303.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,47FEY@766|Rickettsiales	766|Rickettsiales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
k59_142079_1	438753.AZC_0490	3.28e-25	103.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,3EYMA@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_18095	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_142079_2	1304275.C41B8_03216	3.64e-20	90.9	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase
k59_192013_1	1229909.NSED_01185	1.16e-56	179.0	COG1695@1|root,arCOG00002@2157|Archaea,41SN8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k59_192013_2	1229909.NSED_01190	1.06e-219	619.0	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	fumarate reductase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_119166_1	57918.XP_004309938.1	5.33e-41	157.0	COG2801@1|root,KOG0017@2759|Eukaryota,37SNQ@33090|Viridiplantae,3GHRQ@35493|Streptophyta,4JTCD@91835|fabids	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_318552_2	7425.NV30710-PA	1.22e-58	208.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_119184_1	113395.AXAI01000022_gene3544	2.24e-07	52.4	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JT7G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_43210	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_119184_2	296591.Bpro_2799	1.08e-83	253.0	COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,4ACEI@80864|Comamonadaceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
k59_9024_1	1524467.IV04_00400	5.17e-55	186.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,4036M@613|Serratia	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_149401_1	1266925.JHVX01000016_gene179	2.72e-79	243.0	COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,372FP@32003|Nitrosomonadales	28216|Betaproteobacteria	H	pfkB family carbohydrate kinase	adoK	-	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_149402_1	1268622.AVS7_03485	5.34e-59	199.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_158790_1	582744.Msip34_0295	3.95e-113	360.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KMFS@206350|Nitrosomonadales	206350|Nitrosomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_288110_1	27923.ML08883a-PA	8.09e-36	144.0	KOG0977@1|root,KOG1075@1|root,KOG0977@2759|Eukaryota,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_119199_1	580332.Slit_0531	3.74e-77	239.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,44W64@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART protein phosphatase 2C domain protein	pppL	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k59_77635_1	232721.Ajs_2200	1.43e-130	383.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VKAK@28216|Betaproteobacteria,4AJKJ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_158802_1	43151.ADAC007967-PA	1.53e-38	147.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,429UH@6656|Arthropoda,3T0UB@50557|Insecta,458R2@7147|Diptera	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_149425_1	1051646.VITU9109_14883	6.92e-05	47.8	COG4969@1|root,COG4969@2|Bacteria	2|Bacteria	NU	cell adhesion	mshB	-	-	ko:K02456,ko:K02650,ko:K10924,ko:K10925	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,Pilin,T2SSG
k59_149425_2	267608.RSc0691	2.19e-12	66.2	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1K10P@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_29925_1	7029.ACYPI24114-PA	2.13e-43	160.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SQRW@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve
k59_108366_1	1343739.PAP_09700	1.01e-12	67.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	183968|Thermococci	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
k59_129449_1	436308.Nmar_1790	7.6e-187	530.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_209244_1	69319.XP_008547699.1	5.09e-27	113.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria,4224Q@6656|Arthropoda,3SQKC@50557|Insecta,46KTK@7399|Hymenoptera	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_158811_1	323848.Nmul_A0304	1.72e-83	254.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,371W5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
k59_158811_2	1266925.JHVX01000005_gene1938	2.2e-12	64.3	COG3312@1|root,COG3312@2|Bacteria,1R3CS@1224|Proteobacteria,2WIGV@28216|Betaproteobacteria,374P5@32003|Nitrosomonadales	28216|Betaproteobacteria	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k59_9074_1	1108045.GORHZ_109_00020	2.42e-65	219.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
k59_247594_1	1236908.wNo_10390	3.79e-14	72.0	COG0210@1|root,COG0666@1|root,COG0210@2|Bacteria,COG0666@2|Bacteria,1R4JW@1224|Proteobacteria	1224|Proteobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,Ank_2,Ank_5,UvrD-helicase,UvrD_C,Viral_helicase1
k59_247594_2	1236908.wNo_10400	2.67e-161	453.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,47FI0@766|Rickettsiales	766|Rickettsiales	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
k59_77702_1	7176.CPIJ016425-PA	2.6e-42	150.0	2CEB9@1|root,2T8EY@2759|Eukaryota,392Z7@33154|Opisthokonta,3C89K@33208|Metazoa,3DPA8@33213|Bilateria,425IH@6656|Arthropoda,3SV3U@50557|Insecta,456UI@7147|Diptera,45M4H@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_119246_1	570417.WP0552	2.32e-110	332.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4
k59_129494_1	1068980.ARVW01000001_gene3192	3.87e-21	93.2	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4DZ3Q@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_288181_1	7668.SPU_000265-tr	3.12e-37	147.0	COG2801@1|root,KOG0017@2759|Eukaryota,3AH4S@33154|Opisthokonta,3BYA4@33208|Metazoa,3DDH6@33213|Bilateria	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_149476_1	292415.Tbd_0793	4.44e-96	304.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1KRHS@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_209331_1	1280941.HY2_12950	3.02e-19	83.6	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,43XK4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	intracellular protease amidase	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
k59_247637_1	436308.Nmar_0292	8.28e-45	148.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_77744_1	1255043.TVNIR_0128	3e-21	94.4	COG2199@1|root,COG3706@2|Bacteria,1RCC4@1224|Proteobacteria,1S523@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_307065_1	570417.WP0753	2.21e-107	318.0	COG0189@1|root,COG0189@2|Bacteria,1QVU3@1224|Proteobacteria,2U15U@28211|Alphaproteobacteria,47FWY@766|Rickettsiales	766|Rickettsiales	HJ	Glutamate-cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GshA
k59_318715_1	570417.WP0033	8.12e-209	585.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_209369_1	1144319.PMI16_03100	4.07e-33	121.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,473B3@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
k59_209369_2	580332.Slit_0950	5.43e-08	53.5	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,44V0C@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
k59_119306_1	7029.ACYPI52857-PA	2.14e-74	261.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_209378_1	1461580.CCAS010000002_gene350	1.69e-77	250.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,4HF5S@91061|Bacilli,1ZEHD@1386|Bacillus	91061|Bacilli	O	COG1138 Cytochrome c biogenesis factor	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_9179_1	768671.ThimaDRAFT_1335	5.56e-71	225.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1WY7I@135613|Chromatiales	135613|Chromatiales	M	PFAM phospholipase A1	-	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
k59_77793_1	1131266.ARWQ01000001_gene1266	4.21e-47	169.0	COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_288257_1	570417.WP0670	1.54e-163	459.0	2EAQY@1|root,334T6@2|Bacteria,1NFJT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_288257_2	1236908.wNo_02390	6.84e-91	274.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,47EZI@766|Rickettsiales	766|Rickettsiales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_129580_1	330214.NIDE0503	7.56e-144	414.0	COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_237294_1	1266925.JHVX01000007_gene2359	3.4e-104	312.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria,372JZ@32003|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM Aminotransferase, class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_279584_1	7260.FBpp0244144	9.71e-31	129.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta,457GT@7147|Diptera,45YIF@7214|Drosophilidae	33208|Metazoa	L	Pfam:UBN2_2	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,MBD,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_149886_1	7176.CPIJ018258-PA	0.000896	41.2	29KBU@1|root,2RTKP@2759|Eukaryota,3AQ97@33154|Opisthokonta,3C2Q2@33208|Metazoa,3DIFI@33213|Bilateria,424FS@6656|Arthropoda,3STPR@50557|Insecta,457K7@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_169946_1	1419583.V466_22780	1.81e-28	104.0	2AHG4@1|root,317TE@2|Bacteria,1PZ7E@1224|Proteobacteria,1RVJ2@1236|Gammaproteobacteria,1YU3A@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_169946_2	339670.Bamb_4781	1.74e-13	70.1	2DMK8@1|root,32S5F@2|Bacteria,1NNIY@1224|Proteobacteria,2VUQF@28216|Betaproteobacteria,1K9KI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
k59_199842_1	163164.WD_0697	8.68e-25	102.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	zmpC	-	-	ko:K08643,ko:K15481	ko01120,ko05134,map01120,map05134	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FIVAR,G5,PEGA,Peptidase_M26_C,Peptidase_M26_N,YSIRK_signal
k59_30245_1	570417.WP0601	1.34e-118	361.0	COG3704@1|root,COG3704@2|Bacteria,1P76F@1224|Proteobacteria,2UW5H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	TrbL/VirB6 plasmid conjugal transfer protein	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_130039_1	580332.Slit_1461	8.63e-47	153.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2VINU@28216|Betaproteobacteria,44VQN@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF,QueF_N
k59_130039_2	292415.Tbd_1228	4.61e-53	186.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1KS5V@119069|Hydrogenophilales	119069|Hydrogenophilales	L	RecF/RecN/SMC N terminal domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_139977_1	1236908.wNo_07860	1.46e-281	788.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,47F10@766|Rickettsiales	766|Rickettsiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_179866_1	1144888.CM001467_gene110	1.64e-188	531.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,47F8B@766|Rickettsiales	766|Rickettsiales	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
k59_189880_1	1236908.wNo_09880	8.94e-107	324.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,47EUE@766|Rickettsiales	766|Rickettsiales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_219764_1	570417.WP0033	2.49e-48	165.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	alanine symporter	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_219764_2	570417.WP0035	4.1e-49	172.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K18376	-	M00660	-	-	ko00000,ko00002,ko02044	1.C.65.1	-	-	DUF1542,Mob_Pre,Relaxase,YSIRK_signal
k59_249689_1	1236908.wNo_08980	3.42e-112	323.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2TSDM@28211|Alphaproteobacteria,47F3H@766|Rickettsiales	766|Rickettsiales	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_189891_1	1236908.wNo_01410	2.02e-112	324.0	COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria,47G4W@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
k59_179900_1	27923.ML12844a-PA	3.96e-24	105.0	COG3476@1|root,KOG1075@1|root,KOG1075@2759|Eukaryota,KOG3797@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_199879_1	1380355.JNIJ01000006_gene3041	1.74e-54	181.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_100061_2	563031.HMPREF0666_01890	9.73e-11	63.5	COG0541@1|root,COG0541@2|Bacteria,4NDZ2@976|Bacteroidetes,2FNSI@200643|Bacteroidia	976|Bacteroidetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_50258_1	1236908.wNo_07490	1.08e-32	123.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,47F18@766|Rickettsiales	766|Rickettsiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_179910_1	69319.XP_008553167.1	3.04e-25	110.0	2CWTA@1|root,2RV75@2759|Eukaryota,38WQJ@33154|Opisthokonta,3C6CU@33208|Metazoa,3DME6@33213|Bilateria,42CM4@6656|Arthropoda,3SY8M@50557|Insecta,46MJ3@7399|Hymenoptera	69319.XP_008553167.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_229818_1	27923.ML27895a-PA	2.75e-54	200.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_259743_1	400682.PAC_15720214	6.71e-49	166.0	COG2801@1|root,KOG0017@2759|Eukaryota,3A5XY@33154|Opisthokonta,3C0JZ@33208|Metazoa	33154|Opisthokonta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_30304_2	330214.NIDE0418	2.13e-56	185.0	COG2255@1|root,COG2255@2|Bacteria,3J0AU@40117|Nitrospirae	40117|Nitrospirae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
k59_289657_1	570417.WP0002	7.61e-46	158.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,47F5C@766|Rickettsiales	766|Rickettsiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_189910_1	7029.ACYPI39717-PA	1.29e-31	130.0	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI39717-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_170016_1	1288494.EBAPG3_21660	1.65e-155	449.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_179922_1	1288494.EBAPG3_330	1.7e-143	416.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2VJMX@28216|Betaproteobacteria,3724U@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Uncharacterized protein family (UPF0051)	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_140041_1	570417.WP0296	4.81e-103	316.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	ankA	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_216799_1	1236908.wNo_11360	6.96e-15	73.2	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,47EVY@766|Rickettsiales	766|Rickettsiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_216799_2	1236908.wNo_11350	4.18e-184	533.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,47F21@766|Rickettsiales	766|Rickettsiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_105823_1	1236908.wNo_08570	2.54e-117	360.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,47F2B@766|Rickettsiales	766|Rickettsiales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_156077_1	1236908.wNo_04520	3.38e-97	293.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,47EYZ@766|Rickettsiales	766|Rickettsiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
k59_226719_1	1236908.wNo_04850	2.66e-67	215.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,47F6U@766|Rickettsiales	766|Rickettsiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_267049_2	478801.Ksed_22000	1.62e-30	119.0	COG2801@1|root,COG2801@2|Bacteria,2HBU8@201174|Actinobacteria	201174|Actinobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_68005_1	330214.NIDE3977	1.26e-90	275.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
k59_146690_1	570417.WP1108	5.95e-209	585.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria,47GE0@766|Rickettsiales	766|Rickettsiales	U	Sodium:alanine symporter family	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_75361_1	555778.Hneap_1703	8.69e-06	47.8	COG0599@1|root,COG0599@2|Bacteria,1PG95@1224|Proteobacteria,1SY84@1236|Gammaproteobacteria,1X218@135613|Chromatiales	135613|Chromatiales	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_167791_1	7425.NV19075-PA	2.72e-115	383.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RRM_1,RVT_1,rve,zf-H2C2
k59_6617_2	1298867.AUES01000056_gene4789	0.000395	43.9	COG2128@1|root,COG2128@2|Bacteria,1NFKC@1224|Proteobacteria,2TQSD@28211|Alphaproteobacteria,3JUX0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_137944_1	7668.SPU_004392-tr	5.61e-18	87.8	2D0IG@1|root,2S4TS@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_276846_1	1229172.JQFA01000005_gene267	3.18e-24	107.0	COG0642@1|root,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k59_206544_1	358220.C380_13195	2.07e-86	270.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,4AABZ@80864|Comamonadaceae	28216|Betaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
k59_226748_1	1487953.JMKF01000045_gene2870	6.81e-32	123.0	COG1802@1|root,COG1802@2|Bacteria,1G2P5@1117|Cyanobacteria,1HHM7@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
k59_27021_1	335283.Neut_0661	1.48e-34	120.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,373FS@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_267086_2	7668.SPU_015555-tr	1.1e-16	85.5	COG2801@1|root,KOG0017@2759|Eukaryota,39ZQV@33154|Opisthokonta,3BIZ8@33208|Metazoa,3D69X@33213|Bilateria	33208|Metazoa	L	protein heterodimerization activity	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase,RVT_1
k59_197028_1	1187851.A33M_3520	3.25e-67	218.0	COG1529@1|root,COG1529@2|Bacteria,1NNFR@1224|Proteobacteria,2TVHX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	MA20_13965	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_296675_1	698761.RTCIAT899_CH15075	9.07e-53	180.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,4B95G@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
k59_47911_1	570417.WP0068	6.68e-124	362.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4
k59_116511_1	1131266.ARWQ01000017_gene881	2.93e-87	267.0	COG0128@1|root,arCOG04134@2157|Archaea,41S5I@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	-	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
k59_27032_1	1229909.NSED_07010	6.1e-21	94.7	COG3794@1|root,arCOG10350@1|root,arCOG02926@2157|Archaea,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Kazal_1
k59_126736_1	264462.Bd2667	7.5e-60	203.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2MUPB@213481|Bdellovibrionales,2WJZ3@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_245068_1	1236908.wNo_02070	4.13e-29	114.0	COG0500@1|root,COG2226@2|Bacteria,1PXEH@1224|Proteobacteria,2UQTX@28211|Alphaproteobacteria,47G4K@766|Rickettsiales	766|Rickettsiales	Q	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_245068_2	1236908.wNo_02060	1.66e-84	257.0	COG5285@1|root,COG5285@2|Bacteria,1NPJF@1224|Proteobacteria,2VGH4@28211|Alphaproteobacteria,47G1D@766|Rickettsiales	766|Rickettsiales	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
k59_197038_1	1229909.NSED_06180	2.36e-21	92.8	COG0642@1|root,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg,sCache_3_3
k59_197038_2	1229909.NSED_06185	5.26e-20	91.7	COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota	651137|Thaumarchaeota	L	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_296682_1	570417.WP0165	5.67e-224	630.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,47EUE@766|Rickettsiales	766|Rickettsiales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_206569_1	1236908.wNo_04010	2.79e-130	370.0	COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2TUNI@28211|Alphaproteobacteria,47GT2@766|Rickettsiales	766|Rickettsiales	D	Peptidase family M23	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Peptidase_M23
k59_178179_1	1236908.wNo_01350	1.05e-44	169.0	COG0358@1|root,COG3598@1|root,COG0358@2|Bacteria,COG3598@2|Bacteria,1QVDX@1224|Proteobacteria,2TWVK@28211|Alphaproteobacteria,47GR7@766|Rickettsiales	766|Rickettsiales	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25
k59_69232_1	436308.Nmar_1777	1.44e-125	362.0	COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota	651137|Thaumarchaeota	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_147984_1	1229909.NSED_00740	2.49e-76	234.0	COG0106@1|root,arCOG00618@2157|Archaea,41SIG@651137|Thaumarchaeota	651137|Thaumarchaeota	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k59_18239_1	1502851.FG93_00150	7.61e-168	476.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_49181_1	987059.RBXJA2T_17047	6.65e-107	325.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VKSM@28216|Betaproteobacteria,1KNEK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_235973_1	1459636.NTE_02133	6e-10	55.5	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
k59_235973_2	436308.Nmar_0942	1.08e-46	151.0	COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
k59_157255_1	1129794.C427_1559	1.4e-39	143.0	COG1622@1|root,COG2010@1|root,COG4654@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,COG4654@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
k59_316884_1	7029.ACYPI52857-PA	1.97e-88	315.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_169201_1	1122214.AQWH01000003_gene3922	3.56e-07	60.1	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
k59_257844_1	1229909.NSED_09015	9.53e-77	249.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_178209_1	1459636.NTE_02933	3.01e-110	331.0	COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_305914_1	1121405.dsmv_0270	3.82e-55	189.0	COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_178212_1	7176.CPIJ006540-PA	1.68e-70	241.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_89333_2	391624.OIHEL45_19121	9.51e-23	97.4	COG3128@1|root,COG3128@2|Bacteria,1R4AI@1224|Proteobacteria,2U4W7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
k59_117720_2	1122604.JONR01000032_gene66	3.05e-50	162.0	COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,1SU9C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
k59_89336_1	1236908.wNo_11000	3.19e-102	306.0	COG0847@1|root,COG4886@1|root,COG0847@2|Bacteria,COG4886@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,47FA0@766|Rickettsiales	766|Rickettsiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_69268_1	7176.CPIJ014129-PA	2.02e-22	101.0	2EXBQ@1|root,2SZ1E@2759|Eukaryota,3ASET@33154|Opisthokonta,3C3YW@33208|Metazoa,3DJTW@33213|Bilateria,423AS@6656|Arthropoda,3SPY9@50557|Insecta	33208|Metazoa	S	Domain of unknown function (DUF4780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780
k59_305921_1	1229909.NSED_09580	5.86e-42	142.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
k59_305921_2	1131266.ARWQ01000001_gene1359	2.27e-23	92.8	arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_7699_4	926692.AZYG01000085_gene760	1.04e-21	96.7	COG3926@1|root,COG3926@2|Bacteria,1VKYC@1239|Firmicutes	1239|Firmicutes	S	Glycosyl hydrolase 108	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
k59_18287_1	570417.WP0520	6.5e-122	372.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,47F2F@766|Rickettsiales	766|Rickettsiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_49239_1	1122963.AUHB01000016_gene4340	7.06e-15	77.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,36Y1S@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_178240_1	7029.ACYPI52857-PA	2.79e-63	228.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_305938_1	383372.Rcas_0194	1.79e-70	230.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_169238_2	7029.ACYPI52857-PA	1.7e-109	379.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_286836_1	31234.CRE01450	6.3e-06	54.7	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BICY@33208|Metazoa,3D3BQ@33213|Bilateria	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,rve
k59_188869_1	570417.WP1037	1.41e-108	333.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,47EU7@766|Rickettsiales	766|Rickettsiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_257914_1	570417.WP0615	7.43e-220	612.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,47F20@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_139533_1	1236908.wNo_09610	3.28e-98	306.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,47EW9@766|Rickettsiales	766|Rickettsiales	D	Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity)	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_184067_1	580332.Slit_0536	1.35e-197	572.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,44VNC@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GAF,T2SSE,T2SSE_N
k59_312883_1	436308.Nmar_1360	4.43e-36	131.0	COG2968@1|root,arCOG04715@2157|Archaea,41T6R@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
k59_14081_1	9597.XP_008958403.1	4.67e-05	47.0	COG2036@1|root,COG5262@1|root,KOG1744@1|root,KOG1744@2759|Eukaryota,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,KOG3467@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JGKY@40674|Mammalia,35PSM@314146|Euarchontoglires,4MJ8Y@9443|Primates,4N6K1@9604|Hominidae	33208|Metazoa	B	nucleosomal DNA binding	H3F3C	-	-	ko:K11253,ko:K11254	ko05034,ko05202,ko05203,ko05322,map05034,map05202,map05203,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	CENP-T_C,Histone,Histone_H2A_C
k59_153422_1	163164.WD_1041	4.39e-135	415.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	AXH,NADase_NGA
k59_302788_1	1235457.C404_08895	1.56e-06	48.9	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,1K2HA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM molybdopterin binding domain	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
k59_302788_2	380358.XALC_2190	9.54e-55	175.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
k59_54215_2	436308.Nmar_0980	9.88e-108	321.0	COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
k59_94677_1	1236908.wNo_04750	5.03e-177	496.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,47F83@766|Rickettsiales	766|Rickettsiales	C	Quinone oxidoreductase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_94677_4	1236908.wNo_04770	8.2e-37	127.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,47FDI@766|Rickettsiales	766|Rickettsiales	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_84644_1	436308.Nmar_1091	1.27e-123	364.0	COG1378@1|root,arCOG02037@2157|Archaea,41T17@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
k59_123885_1	570417.WP0599	5.7e-84	273.0	COG3704@1|root,COG3704@2|Bacteria,1NIX6@1224|Proteobacteria,2UK4E@28211|Alphaproteobacteria,47F7M@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_293640_2	62928.azo2415	6.49e-78	248.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,2KUJQ@206389|Rhodocyclales	206389|Rhodocyclales	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
k59_54241_1	1236908.wNo_00970	5.83e-45	145.0	COG4391@1|root,COG4391@2|Bacteria	2|Bacteria	S	Zinc-finger domain	MA20_32275	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
k59_54241_2	1236908.wNo_00960	3.45e-28	106.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,2TZY0@28211|Alphaproteobacteria,47GUC@766|Rickettsiales	766|Rickettsiales	S	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
k59_134498_1	7425.NV24518-PA	3.67e-51	191.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AV5E@33154|Opisthokonta,3C3DB@33208|Metazoa,3DJZQ@33213|Bilateria	2759|Eukaryota	L	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4283,Exo_endo_phos_2,RNase_H,RVT_1,zf-CCHC_4
k59_103312_1	1321779.HMPREF1984_01073	5.44e-06	48.1	COG4696@1|root,COG4696@2|Bacteria,37C2V@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	PRA-PH
k59_294817_2	1236908.wNo_07710	8.76e-48	161.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2U1NV@28211|Alphaproteobacteria,47GRQ@766|Rickettsiales	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_224760_1	472759.Nhal_1430	1.51e-83	259.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales	135613|Chromatiales	E	PFAM Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k59_124958_1	1229909.NSED_01505	6.21e-91	275.0	COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_135832_1	7070.TC016129-PA	2.68e-105	356.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_185385_1	570417.WP1094	6.01e-291	806.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,47F11@766|Rickettsiales	766|Rickettsiales	C	NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G)	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
k59_204918_1	1131266.ARWQ01000001_gene1114	1.74e-14	70.9	COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
k59_204918_2	1131266.ARWQ01000001_gene1115	7.9e-120	349.0	COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
k59_96066_1	1229909.NSED_01090	2.89e-92	283.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_243646_1	27923.ML351743a-PA	2.13e-32	131.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	1.14.14.19,1.14.14.32	ko:K00512,ko:K10448	ko00140,ko01100,ko04913,ko04917,ko04927,ko04934,map00140,map01100,map04913,map04917,map04927,map04934	M00109,M00110	R02211,R03783,R04852,R04853,R08517,R08518	RC00607,RC00660,RC00923,RC01222	ko00000,ko00001,ko00002,ko00199,ko01000,ko04121	-	-	-	RVT_1,zf-RVT
k59_35799_1	7176.CPIJ013333-PA	1.09e-20	93.2	KOG0494@1|root,KOG0494@2759|Eukaryota,3APVI@33154|Opisthokonta,3C1Z9@33208|Metazoa,3DIDN@33213|Bilateria,422YG@6656|Arthropoda,3SZ7U@50557|Insecta,458PX@7147|Diptera,45J6X@7148|Nematocera	33208|Metazoa	K	Homeodomain	-	-	-	-	-	-	-	-	-	-	-	-	Homeobox
k59_265125_1	1380394.JADL01000013_gene772	2.75e-86	264.0	COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,2TS6S@28211|Alphaproteobacteria,2JV53@204441|Rhodospirillales	204441|Rhodospirillales	P	Sodium/calcium exchanger protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_Ca_ex
k59_96075_1	436308.Nmar_1070	1.92e-82	259.0	COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k59_124974_1	7176.CPIJ014761-PA	7.57e-54	193.0	2BZY6@1|root,2S2KI@2759|Eukaryota,39N5Q@33154|Opisthokonta,3CPR0@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-CCHC
k59_165729_1	395493.BegalDRAFT_2031	1.12e-25	99.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	EVE domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_215045_1	7029.ACYPI38899-PA	1.72e-19	94.7	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_65973_1	1458357.BG58_01525	7.33e-54	178.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2VHZG@28216|Betaproteobacteria,1K0M7@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_65973_2	1288494.EBAPG3_27530	1.87e-52	181.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,371VT@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
k59_204936_1	1122182.KB903838_gene4056	1.22e-12	75.1	COG2133@1|root,COG2133@2|Bacteria,2HEMB@201174|Actinobacteria,4DA70@85008|Micromonosporales	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PA14,PKD
k59_135876_1	570417.WP0679	1.04e-72	222.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,47FFC@766|Rickettsiales	766|Rickettsiales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_265145_1	5207.AAW44070	2.61e-18	89.7	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,3UXZ9@5204|Basidiomycota,3VEK4@5234|Tremellales	4751|Fungi	L	Coprinopsis cinerea okayama7 130	-	GO:0003674,GO:0003824,GO:0003964,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Chromo,Peptidase_A2E,RVP_2,RVT_1,Retrotrans_gag,rve
k59_154576_1	7029.ACYPI38036-PA	1.85e-24	106.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_175171_1	7029.ACYPI24114-PA	2.78e-10	67.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SQRW@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve
k59_15306_1	436308.Nmar_1661	4.01e-52	167.0	COG1733@1|root,arCOG01057@2157|Archaea,41T7C@651137|Thaumarchaeota	651137|Thaumarchaeota	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
k59_204957_1	7425.NV23775-PA	5.04e-05	50.8	2CW5U@1|root,2RTQJ@2759|Eukaryota,3A8VZ@33154|Opisthokonta,3C8PR@33208|Metazoa,3DPR6@33213|Bilateria,42BVK@6656|Arthropoda,3SVJM@50557|Insecta,46MJF@7399|Hymenoptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2
k59_145103_1	570417.WP0129	1.93e-159	458.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TWMA@28211|Alphaproteobacteria,47GT4@766|Rickettsiales	766|Rickettsiales	CP	Proton-conducting membrane transporter	nuoL2	-	1.6.5.3	ko:K00341,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_204959_1	1049564.TevJSym_aj00270	1.01e-62	202.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1J4MW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
k59_224838_1	7425.NV18588-PA	2.48e-33	135.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_15312_1	10224.XP_006813780.1	3.18e-83	260.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y9N@33154|Opisthokonta,3BKRZ@33208|Metazoa,3CWQ0@33213|Bilateria	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_135908_1	864051.BurJ1DRAFT_2017	2e-27	115.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N17V@1224|Proteobacteria,2VK7C@28216|Betaproteobacteria,1KJYS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07642,ko:K18143	ko01501,ko02020,map01501,map02020	M00450,M00645,M00646,M00648,M00649,M00655	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA
k59_35864_1	575606.HMPREF0525_00117	0.000147	43.9	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,4H9WZ@91061|Bacilli,3F4V1@33958|Lactobacillaceae	91061|Bacilli	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_35864_2	1288494.EBAPG3_28130	1.54e-45	159.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_265177_1	10224.XP_006825930.1	4.22e-24	106.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_204967_2	1144319.PMI16_03951	8.91e-25	101.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,472KW@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class I and II	tyrB	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_25390_1	1229909.NSED_00175	1.32e-42	145.0	COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_25390_2	1229909.NSED_00180	1.1e-84	267.0	COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_175184_2	7070.TC011220-PA	2.12e-120	396.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_125036_1	7159.AAEL017004-PA	5.75e-07	58.2	KOG1864@1|root,KOG1864@2759|Eukaryota,38BB6@33154|Opisthokonta,3BEQW@33208|Metazoa,3CRNZ@33213|Bilateria,41YD9@6656|Arthropoda,3SFQD@50557|Insecta,4504Q@7147|Diptera,45GWW@7148|Nematocera	33208|Metazoa	O	Ubiquitin carboxyl-terminal hydrolase	USP46	GO:0000578,GO:0001662,GO:0002209,GO:0002682,GO:0002684,GO:0003002,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004843,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006950,GO:0006952,GO:0007275,GO:0007350,GO:0007351,GO:0007389,GO:0007610,GO:0007631,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008343,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009605,GO:0009636,GO:0009790,GO:0009798,GO:0009880,GO:0009893,GO:0009948,GO:0009952,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010469,GO:0010604,GO:0010628,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0016579,GO:0016787,GO:0019222,GO:0019538,GO:0019783,GO:0019941,GO:0022898,GO:0023051,GO:0023056,GO:0023057,GO:0030163,GO:0030534,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032228,GO:0032409,GO:0032412,GO:0032501,GO:0032502,GO:0032879,GO:0033555,GO:0034762,GO:0034765,GO:0035254,GO:0035255,GO:0035282,GO:0036211,GO:0036459,GO:0036477,GO:0040012,GO:0040017,GO:0042221,GO:0042493,GO:0042596,GO:0043025,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043269,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0045746,GO:0046677,GO:0048149,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048856,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050795,GO:0050804,GO:0050854,GO:0050856,GO:0050857,GO:0050862,GO:0050896,GO:0051049,GO:0051603,GO:0060004,GO:0060013,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0070013,GO:0070646,GO:0070647,GO:0071704,GO:0071947,GO:0090325,GO:0090326,GO:0097305,GO:0097458,GO:0097708,GO:0099177,GO:0099601,GO:0101005,GO:0140096,GO:1900449,GO:1901564,GO:1901565,GO:1901575,GO:1901700,GO:1904062,GO:2000311,GO:2001257	3.4.19.12	ko:K11842	-	-	-	-	ko00000,ko01000,ko01002,ko04121	-	-	-	UCH
k59_294918_1	398580.Dshi_0314	5.03e-09	57.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
k59_294918_2	1131266.ARWQ01000017_gene892	9.6e-90	271.0	COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Major Intrinsic Protein	-	-	-	ko:K06188,ko:K09866	ko04962,ko04976,map04962,map04976	-	-	-	ko00000,ko00001,ko02000	1.A.8	-	-	MIP
k59_242821_1	1005048.CFU_3260	7.9e-86	279.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,473U5@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_153599_1	436308.Nmar_0009	3.68e-34	123.0	arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_153599_2	436308.Nmar_0417	4.93e-46	151.0	arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_283303_1	1589748.A0A0B5A5M2_9CAUD	7.46e-17	79.7	4QD50@10239|Viruses,4QPSB@28883|Caudovirales	28883|Caudovirales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_64683_1	522306.CAP2UW1_3650	1.11e-85	267.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_14274_1	543913.D521_1710	1.79e-30	114.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2VT23@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_24266_2	744980.TRICHSKD4_5594	2.42e-34	127.0	COG2382@1|root,COG2382@2|Bacteria,1QX0K@1224|Proteobacteria,2TYA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
k59_103471_1	1423144.Gal_00283	1.95e-07	53.5	COG0697@1|root,COG0697@2|Bacteria,1MY2U@1224|Proteobacteria,2TV71@28211|Alphaproteobacteria,34DYR@302485|Phaeobacter	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_103471_2	76114.ebA4051	8.31e-26	107.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales	206389|Rhodocyclales	C	Domain of unknown function (DUF3390)	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
k59_54482_1	570417.WP0821	3.59e-52	174.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,47F0P@766|Rickettsiales	766|Rickettsiales	E	COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes	spl1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_54482_2	570417.WP0822	1.2e-35	126.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,47F70@766|Rickettsiales	766|Rickettsiales	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
k59_44834_1	570417.WP1364	1.96e-65	207.0	COG3039@1|root,COG3039@2|Bacteria,1RBRB@1224|Proteobacteria,2U6SM@28211|Alphaproteobacteria,47F69@766|Rickettsiales	766|Rickettsiales	L	IS2 (IS982-family)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_44834_2	163164.WD_1297	2.88e-39	140.0	COG3240@1|root,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Big_3_5,Lipase_GDSL,Pertactin
k59_293829_1	1236908.wNo_11230	1.5e-201	565.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2TV8B@28211|Alphaproteobacteria,47EXZ@766|Rickettsiales	766|Rickettsiales	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_164593_1	7029.ACYPI009216-PA	1.34e-90	309.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_232936_1	1229909.NSED_03625	8.42e-81	248.0	arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_302967_1	1232437.KL662007_gene1687	1.41e-35	126.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,42WFU@68525|delta/epsilon subdivisions,2WS4T@28221|Deltaproteobacteria,2MKX1@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_293830_1	436308.Nmar_0030	7.17e-06	52.4	arCOG06534@1|root,arCOG06534@2157|Archaea	2157|Archaea	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
k59_293830_2	926690.KE386573_gene489	0.000225	42.7	COG0412@1|root,arCOG01659@2157|Archaea,2XZUN@28890|Euryarchaeota,23Z6A@183963|Halobacteria	183963|Halobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
k59_313113_1	436308.Nmar_0088	2e-101	320.0	COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
k59_164596_1	1266925.JHVX01000023_gene2428	2.3e-60	193.0	arCOG08699@1|root,30TCX@2|Bacteria,1RDPE@1224|Proteobacteria,2WAZQ@28216|Betaproteobacteria,371U8@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	AmoC
k59_73295_1	1459636.NTE_02911	3.71e-42	155.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	2157|Archaea	O	PFAM TCP-1 cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_293832_1	323848.Nmul_A2553	1.09e-84	270.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,372MQ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_174205_1	570417.WP0688	2.29e-51	178.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47GS5@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_313140_1	281687.CJA15137	2.66e-10	67.4	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3DKJZ@33213|Bilateria,40GWW@6231|Nematoda,1KZYW@119089|Chromadorea,412EV@6236|Rhabditida	33208|Metazoa	K	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_34837_1	7029.ACYPI009216-PA	2.45e-52	191.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_124109_1	436308.Nmar_0240	5.4e-163	463.0	COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Replication factor C	-	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	DNA_pol3_delta2,Rep_fac_C,RuvB_N
k59_73319_1	195250.CM001776_gene1557	1.38e-28	118.0	COG2059@1|root,COG2059@2|Bacteria,1G37Z@1117|Cyanobacteria,1H067@1129|Synechococcus	1117|Cyanobacteria	P	chromate transport protein	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
k59_34840_1	1459636.NTE_02261	2.74e-38	142.0	COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
k59_194176_1	565045.NOR51B_2541	8.73e-27	114.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iG2583_1286.G2583_0058	OstA,OstA_C
k59_184386_2	35754.JNYJ01000009_gene1906	3.15e-25	101.0	2BCAG@1|root,325VQ@2|Bacteria,2HB5M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_283355_1	570417.WP0709	2.9e-32	124.0	COG3064@1|root,COG3064@2|Bacteria,1QW24@1224|Proteobacteria,2TWYU@28211|Alphaproteobacteria,47GT5@766|Rickettsiales	766|Rickettsiales	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k59_283355_2	570417.WP0711	3.4e-118	343.0	COG5449@1|root,COG5449@2|Bacteria,1MXK2@1224|Proteobacteria,2TTWS@28211|Alphaproteobacteria,47FMC@766|Rickettsiales	766|Rickettsiales	S	Phage conserved hypothetical protein BR0599	-	-	-	-	-	-	-	-	-	-	-	-	DUF2163,Phage_BR0599
k59_144193_1	498211.CJA_0866	2.23e-39	144.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1FG1T@10|Cellvibrio	1236|Gammaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	iJN746.PP_0104	COX1
k59_144193_2	323848.Nmul_A1777	4.44e-97	293.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,37299@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_144201_1	1385935.N836_34245	4.11e-54	183.0	2DBFF@1|root,2Z8YA@2|Bacteria,1G2KB@1117|Cyanobacteria,1HFHB@1150|Oscillatoriales	1117|Cyanobacteria	L	Helix-turn-helix of DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_84966_1	570417.WP0950	7.47e-138	401.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,47F4T@766|Rickettsiales	766|Rickettsiales	S	TldD protein	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_264176_1	1178482.BJB45_11780	1.33e-98	310.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XHEU@135619|Oceanospirillales	135619|Oceanospirillales	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_44923_1	570417.WP0930	8.1e-136	385.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,47FJV@766|Rickettsiales	766|Rickettsiales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
k59_114161_1	580332.Slit_2983	2.98e-181	516.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,44V6D@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_103549_2	436308.Nmar_0418	3.41e-25	98.6	arCOG04033@1|root,arCOG04033@2157|Archaea,41SM5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_144211_1	1229909.NSED_01610	3.18e-50	161.0	arCOG06055@1|root,arCOG06055@2157|Archaea,41SQ3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_144211_2	436308.Nmar_0336	1.75e-55	186.0	COG1032@1|root,arCOG01357@2157|Archaea,41S86@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_204074_1	28564.XP_002486181.1	7.47e-09	64.7	COG0457@1|root,KOG4658@1|root,KOG1840@2759|Eukaryota,KOG4658@2759|Eukaryota,38C2F@33154|Opisthokonta,3NYVZ@4751|Fungi,3QJJI@4890|Ascomycota,20AWC@147545|Eurotiomycetes,3S4I8@5042|Eurotiales	4751|Fungi	Z	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,PNP_UDP_1,TPR_10,TPR_12,TPR_7,TPR_8
k59_242905_1	28377.ENSACAP00000022290	7.84e-46	169.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BGB6@33208|Metazoa,3E4E9@33213|Bilateria,48KK2@7711|Chordata,49MPT@7742|Vertebrata	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve
k59_184416_1	7070.TC010553-PA	7.38e-112	343.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_44939_1	1229909.NSED_08165	4.34e-30	119.0	COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota	651137|Thaumarchaeota	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_44942_1	665959.HMPREF1013_00686	1.64e-17	88.6	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4HB7U@91061|Bacilli,1ZEBW@1386|Bacillus	91061|Bacilli	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_95046_1	1236908.wNo_01670	8.7e-30	115.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the peptidase M16 family	MA20_05655	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_95046_2	1236908.wNo_01680	3.63e-142	410.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,47F9M@766|Rickettsiales	766|Rickettsiales	S	Peptidase, M16 family	-	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_124146_1	1236908.wNo_09140	7.49e-79	265.0	COG1672@1|root,COG5539@1|root,COG1672@2|Bacteria,COG5539@2|Bacteria	2|Bacteria	O	protein K27-linked deubiquitination	-	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0036210,GO:0036211,GO:0043087,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044033,GO:0044238,GO:0046872,GO:0050568,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009,GO:0071704,GO:0140096,GO:1901564	-	ko:K06921,ko:K15354	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	AAA_16,KAP_NTPase,Mrr_cat,NACHT,SIR2_2,Tox-PLDMTX
k59_24385_1	570417.WP0606	0.00025	45.1	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4
k59_24385_2	7425.NV16216-PA	8.22e-05	47.4	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria,41TJ6@6656|Arthropoda	33208|Metazoa	M	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,PRANC
k59_144226_1	67593.Physo139853	1.61e-14	85.1	COG2801@1|root,KOG0017@2759|Eukaryota,3QH6E@4776|Peronosporales	67593.Physo139853|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_204099_2	436308.Nmar_1062	1.51e-51	174.0	arCOG11548@1|root,arCOG11548@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114206_1	1131266.ARWQ01000008_gene308	1.65e-45	160.0	COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
k59_114206_2	9778.XP_004373417.1	3.18e-19	87.0	COG0105@1|root,KOG0888@2759|Eukaryota,3A01M@33154|Opisthokonta,3BPJ3@33208|Metazoa,3D696@33213|Bilateria,48A2A@7711|Chordata,49731@7742|Vertebrata,3JBAC@40674|Mammalia,34SN8@311790|Afrotheria	33208|Metazoa	F	Nucleoside diphosphate kinase	NME4	GO:0003674,GO:0003824,GO:0004550,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005758,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0008289,GO:0009116,GO:0009117,GO:0009132,GO:0009987,GO:0010876,GO:0010941,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0019866,GO:0019899,GO:0031090,GO:0031966,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0033036,GO:0034641,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0046483,GO:0046939,GO:0050789,GO:0050794,GO:0051020,GO:0051179,GO:0051234,GO:0055086,GO:0065007,GO:0070013,GO:0071702,GO:0071704,GO:1901135,GO:1901360,GO:1901564,GO:1901611,GO:1901612,GO:1901657	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_214137_1	331869.BAL199_05849	4.02e-22	92.8	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2TURT@28211|Alphaproteobacteria,4BRS8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_86535_1	570417.WP1215	6.59e-14	70.1	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,47F65@766|Rickettsiales	766|Rickettsiales	M	COG0739 Membrane proteins related to metalloendopeptidases	nlpD2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_86535_2	570417.WP1216	5.81e-156	441.0	COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,2TTBE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k59_136537_1	1459636.NTE_01051	9.82e-112	344.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_215656_1	265072.Mfla_0474	3.07e-38	130.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,2KMXW@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
k59_215656_2	1122614.JHZF01000013_gene3737	9.4e-36	130.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VF8I@28211|Alphaproteobacteria,2PECP@252301|Oceanicola	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_247911_1	323848.Nmul_A0493	3.17e-59	183.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,373C7@32003|Nitrosomonadales	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_247911_2	522306.CAP2UW1_1214	2.95e-47	170.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1KPNC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_159135_1	570417.WP0391	0.0	922.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,47EYR@766|Rickettsiales	766|Rickettsiales	O	Cytochrome c-type biogenesis protein ccmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_119542_3	1340493.JNIF01000004_gene1160	3.29e-125	382.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA,TniB
k59_119542_9	314230.DSM3645_14460	4.08e-18	78.6	2E86B@1|root,332JP@2|Bacteria,2J106@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_237505_1	706587.Desti_1905	2.7e-97	302.0	COG3464@1|root,COG3464@2|Bacteria,1QZI9@1224|Proteobacteria,43CJK@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_237512_1	7159.AAEL017571-PA	4.36e-90	284.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_9514_1	1131266.ARWQ01000012_gene1624	6.03e-62	199.0	COG3958@1|root,arCOG01051@2157|Archaea,41SEP@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_9514_2	1131266.ARWQ01000012_gene1625	7.06e-72	220.0	COG0176@1|root,arCOG05061@2157|Archaea,41S99@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
k59_248015_1	436308.Nmar_1389	9.38e-22	92.8	COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
k59_248015_2	246969.TAM4_1200	1.76e-38	139.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2430R@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_159255_1	555779.Dthio_PD0022	9.57e-83	264.0	COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
k59_237580_1	36914.XP_001526494.1	2.18e-09	61.2	COG2801@1|root,KOG0017@2759|Eukaryota,3ACW4@33154|Opisthokonta	33154|Opisthokonta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
k59_108873_1	1229909.NSED_08165	3.19e-83	267.0	COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota	651137|Thaumarchaeota	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_159264_1	1049564.TevJSym_ad01310	8.23e-33	120.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1J6CX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	yjcF	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
k59_159264_2	32049.SYNPCC7002_A2590	1.07e-06	49.3	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1G0Q0@1117|Cyanobacteria,1H06P@1129|Synechococcus	1117|Cyanobacteria	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
k59_78255_1	436308.Nmar_1337	1.14e-13	67.4	COG0668@1|root,arCOG01568@2157|Archaea	2157|Archaea	M	mechanosensitive ion channel	mscS1	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
k59_288636_1	1236908.wNo_01580	1.09e-51	176.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,47FW6@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_288636_2	1236908.wNo_01590	5.62e-34	123.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2TTT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	membrane protein TerC	terC	-	-	-	-	-	-	-	-	-	-	-	TerC
k59_288642_1	322710.Avin_20870	3.97e-31	122.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
k59_288642_2	266834.SM_b20525	1.13e-05	51.2	COG1309@1|root,COG1309@2|Bacteria,1RBS8@1224|Proteobacteria,2U3P5@28211|Alphaproteobacteria,4BDPQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
k59_288657_1	331869.BAL199_05844	1.35e-52	175.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,4BRVN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
k59_288657_2	1122218.KB893653_gene826	1.35e-22	94.7	COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,2TURT@28211|Alphaproteobacteria,1JQZ6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
k59_237651_1	1123393.KB891328_gene588	8e-105	319.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1KSV9@119069|Hydrogenophilales	119069|Hydrogenophilales	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE,T2SSE_N
k59_248085_1	1042209.HK44_020925	9.2e-143	432.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,1RP3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_288664_1	1461579.CCNK01000044_gene2206	5.12e-41	142.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1Y8NV@135625|Pasteurellales	135625|Pasteurellales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
k59_78318_1	543913.D521_1956	2.32e-06	52.4	2C5U9@1|root,318BZ@2|Bacteria,1RK4D@1224|Proteobacteria,2VTKM@28216|Betaproteobacteria,1KQWC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
k59_78318_2	999541.bgla_1g35570	3.59e-19	80.1	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7MM@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_9670_1	7425.NV18233-PA	2.96e-65	228.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXJQ@33208|Metazoa,3DGER@33213|Bilateria,422ER@6656|Arthropoda,3SR16@50557|Insecta,46M71@7399|Hymenoptera	33208|Metazoa	S	Domain of unknown function (DUF4780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780,Exo_endo_phos_2,RNase_H,RVT_1
k59_288669_1	570417.WP1051	2.57e-95	309.0	COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gram_pos_anchor,LRR_5,YSIRK_signal,YadA_anchor,YadA_head,YadA_stalk
k59_237656_1	1236908.wNo_09320	8.74e-38	127.0	COG0267@1|root,COG0267@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
k59_237656_2	570417.WP0141	0.0	962.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,47EZK@766|Rickettsiales	766|Rickettsiales	J	Ribonucleases G and E	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_248102_1	7159.AAEL017299-PA	2.65e-48	176.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_248111_1	1236908.wNo_07340	4.38e-217	602.0	COG4385@1|root,COG4385@2|Bacteria,1MYT3@1224|Proteobacteria,2VGCQ@28211|Alphaproteobacteria,47G09@766|Rickettsiales	766|Rickettsiales	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
k59_307526_1	562970.Btus_2752	2.52e-45	164.0	COG5433@1|root,COG5433@2|Bacteria,1V3B8@1239|Firmicutes,4HXV7@91061|Bacilli	91061|Bacilli	L	PFAM Transposase_11	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
k59_9714_1	330214.NIDE1052	7.39e-35	121.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
k59_248117_1	1236908.wNo_05210	1.4e-156	445.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,47F61@766|Rickettsiales	766|Rickettsiales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,SMC_N
k59_78388_1	1236908.wNo_01740	9.94e-95	277.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria,47FD9@766|Rickettsiales	766|Rickettsiales	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_248130_1	330214.NIDE4382	1.72e-72	224.0	COG0400@1|root,COG0400@2|Bacteria,3J1DU@40117|Nitrospirae	40117|Nitrospirae	S	Alpha/beta hydrolase family	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_248130_2	1218074.BAXZ01000018_gene3699	2.4e-16	78.6	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2VH7S@28216|Betaproteobacteria,1K1NK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the UPF0061 (SELO) family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
k59_109026_1	570417.WP0580	6.3e-158	444.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,47EX7@766|Rickettsiales	766|Rickettsiales	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
k59_151300_1	570417.WP0900	1.86e-78	234.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,47FEP@766|Rickettsiales	766|Rickettsiales	O	bacterioferritin comigratory protein	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_151300_2	1236908.wNo_05210	1.59e-33	124.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,47F61@766|Rickettsiales	766|Rickettsiales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_21,SMC_N
k59_211278_1	330214.NIDE0366	4.08e-50	164.0	COG1664@1|root,COG1664@2|Bacteria,3J1F5@40117|Nitrospirae	40117|Nitrospirae	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_81960_1	1120966.AUBU01000013_gene510	2.24e-08	61.6	COG2911@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG2911@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,4NUIW@976|Bacteroidetes	976|Bacteroidetes	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	CUB
k59_261295_1	7070.TC012952-PA	9.75e-72	238.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve,zf-CCHC,zf-H2C2
k59_171580_1	322855.Q52PM4_9CAUD	1.42e-05	47.8	4QH10@10239|Viruses,4QVVN@35237|dsDNA viruses  no RNA stage,4QSY9@28883|Caudovirales	28883|Caudovirales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_171580_2	642227.HA49_08550	2.09e-54	176.0	2BVDA@1|root,30YKI@2|Bacteria,1PKH2@1224|Proteobacteria,1TJIJ@1236|Gammaproteobacteria,4BVW8@82986|Tatumella	1236|Gammaproteobacteria	S	DNA-packaging protein gp3	-	-	-	-	-	-	-	-	-	-	-	-	GP3_package
k59_61744_1	316058.RPB_0452	4.76e-36	123.0	298AC@1|root,31CAJ@2|Bacteria,1P0XH@1224|Proteobacteria,2UV0Z@28211|Alphaproteobacteria,3K4KY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
k59_61744_2	195250.CM001776_gene2131	2.79e-33	117.0	2E3CI@1|root,32MS5@2|Bacteria,1GFXB@1117|Cyanobacteria	1117|Cyanobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
k59_81967_1	1131266.ARWQ01000001_gene1169	1.02e-48	163.0	COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	tRNA methyl transferase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC
k59_51778_1	266264.Rmet_4609	7.53e-48	165.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1KGHE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_21820_1	1454004.AW11_02062	4.04e-46	168.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KPY3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
k59_131795_1	330214.NIDE0860	5.32e-88	287.0	COG1196@1|root,COG1196@2|Bacteria,3J0W4@40117|Nitrospirae	40117|Nitrospirae	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
k59_131804_1	1229909.NSED_08685	1.9e-136	396.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
k59_61764_1	1131266.ARWQ01000003_gene1510	3.23e-98	299.0	COG0843@1|root,arCOG01237@2157|Archaea,41S9Z@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Heme copper-type cytochrome quinol	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_111678_1	5811.TGME49_116330	1.15e-32	124.0	COG0605@1|root,KOG0876@2759|Eukaryota,3YA45@5794|Apicomplexa,3YNMF@5796|Coccidia,3YS7D@5809|Sarcocystidae	5794|Apicomplexa	P	Superoxide dismutase	SODB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
k59_291225_1	281687.CJA08386a	1.06e-19	91.7	COG1112@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1801@2759|Eukaryota,39MJ8@33154|Opisthokonta,3CP60@33208|Metazoa,3E5A5@33213|Bilateria,40RE0@6231|Nematoda,1M8IA@119089|Chromadorea,4178W@6236|Rhabditida	2759|Eukaryota	A	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_12,Asp_protease_2,zf-CCHC
k59_230950_1	1236908.wNo_01500	1.89e-107	319.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria,47EV2@766|Rickettsiales	766|Rickettsiales	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
k59_211340_1	1408164.MOLA814_00004	3.48e-112	338.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VMNB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxN	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_161811_1	1131266.ARWQ01000001_gene1180	7.97e-87	273.0	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_1710_1	7213.XP_004520233.1	4.56e-83	281.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_240819_1	13037.EHJ73416	4.62e-35	147.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,41V5R@6656|Arthropoda,3SINZ@50557|Insecta	33208|Metazoa	S	RNase H	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_21857_1	7070.TC001491-PA	4.14e-43	160.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_141228_1	436308.Nmar_0657	6.54e-75	237.0	COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_250906_1	448385.sce7305	4.86e-49	172.0	COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42PWB@68525|delta/epsilon subdivisions,2X5K5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,PEP_mutase
k59_290889_1	7425.NV18377-PA	1.53e-10	72.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_191185_1	1236908.wNo_07330	7.06e-97	288.0	COG3948@1|root,COG3948@2|Bacteria,1MUFF@1224|Proteobacteria,2TT6I@28211|Alphaproteobacteria,47FPY@766|Rickettsiales	766|Rickettsiales	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
k59_230703_1	7176.CPIJ040082-PA	4.44e-192	537.0	COG1005@1|root,KOG4770@2759|Eukaryota,39SC3@33154|Opisthokonta,3BGSE@33208|Metazoa,3D3H4@33213|Bilateria,421VX@6656|Arthropoda,3SP05@50557|Insecta,44XGC@7147|Diptera,45EJH@7148|Nematocera	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	ND1	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010033,GO:0010257,GO:0014070,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030425,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0033194,GO:0034622,GO:0034641,GO:0036477,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044463,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0097447,GO:0097458,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0120025,GO:0120038,GO:1901135,GO:1901360,GO:1901564,GO:1901700,GO:1902494,GO:1990204	1.6.5.3	ko:K03878	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADHdh
k59_230703_2	7159.AAEL018685-PA	1e-269	738.0	COG1290@1|root,KOG4663@2759|Eukaryota,38FBZ@33154|Opisthokonta,3BCGI@33208|Metazoa,3CZ4H@33213|Bilateria,41ZKH@6656|Arthropoda,3SJNY@50557|Insecta,451FJ@7147|Diptera,45GXE@7148|Nematocera	33208|Metazoa	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis	CYTB	GO:0000003,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005750,GO:0006091,GO:0006119,GO:0006122,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0007275,GO:0007276,GO:0007283,GO:0007584,GO:0008121,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009605,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016681,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019953,GO:0020037,GO:0022414,GO:0022900,GO:0022904,GO:0031090,GO:0031099,GO:0031100,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031667,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032504,GO:0032592,GO:0032991,GO:0033273,GO:0033590,GO:0033762,GO:0034220,GO:0034641,GO:0036293,GO:0036296,GO:0042221,GO:0042493,GO:0042538,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044703,GO:0044877,GO:0045275,GO:0045333,GO:0045471,GO:0046034,GO:0046483,GO:0046677,GO:0046686,GO:0046688,GO:0046689,GO:0046906,GO:0048037,GO:0048038,GO:0048039,GO:0048232,GO:0048513,GO:0048609,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051592,GO:0051704,GO:0055085,GO:0055086,GO:0055093,GO:0055114,GO:0070069,GO:0070469,GO:0070482,GO:0071704,GO:0072521,GO:0097159,GO:0097305,GO:0098573,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901652,GO:1901698,GO:1901700,GO:1902494,GO:1902600,GO:1990204	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_230703_3	7176.CPIJ040077-PA	1.16e-44	150.0	2FBK6@1|root,2TCTS@2759|Eukaryota,398D8@33154|Opisthokonta,3CCMC@33208|Metazoa,3DTXR@33213|Bilateria,42523@6656|Arthropoda,3SR93@50557|Insecta,4540V@7147|Diptera,45INE@7148|Nematocera	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	ND6	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.6.5.3	ko:K03884	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q3
k59_230703_4	7159.AAEL018681-PA	1.09e-35	124.0	KOG4669@1|root,KOG4669@2759|Eukaryota,3A6ST@33154|Opisthokonta,3BTQI@33208|Metazoa,3D9QQ@33213|Bilateria,4289Q@6656|Arthropoda,3SRUM@50557|Insecta,4547U@7147|Diptera,45J9N@7148|Nematocera	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	ND4L	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0071704,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K03882	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q2
k59_230703_5	7159.AAEL018680-PA	9.08e-240	667.0	COG1008@1|root,KOG4845@2759|Eukaryota,39UFQ@33154|Opisthokonta,3BDEW@33208|Metazoa,3D0T7@33213|Bilateria,422HB@6656|Arthropoda,3SNAJ@50557|Insecta,452UB@7147|Diptera,45EBY@7148|Nematocera	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	ND4	GO:0001666,GO:0001701,GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007005,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007568,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009628,GO:0009636,GO:0009790,GO:0009792,GO:0009987,GO:0010033,GO:0010257,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0021549,GO:0022037,GO:0022607,GO:0022900,GO:0022904,GO:0030902,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0035094,GO:0036293,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0043009,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0045471,GO:0046034,GO:0046483,GO:0046677,GO:0048513,GO:0048731,GO:0048856,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0060322,GO:0065003,GO:0070469,GO:0070482,GO:0071704,GO:0071840,GO:0072521,GO:0097305,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1901700,GO:1902494,GO:1990204	1.6.5.3	ko:K03881	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	Oxidored_q5_N,Proton_antipo_M
k59_230703_6	7159.AAEL018678-PA	0.0	914.0	COG1007@1|root,KOG4668@2759|Eukaryota,38F5W@33154|Opisthokonta,3BEVW@33208|Metazoa,3CTS4@33213|Bilateria,4203F@6656|Arthropoda,3SM8H@50557|Insecta,451X3@7147|Diptera,45BQK@7148|Nematocera	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	ND5	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009628,GO:0009636,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010257,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042773,GO:0042775,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0046677,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0070482,GO:0071704,GO:0071840,GO:0072521,GO:0097458,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0120025,GO:1901135,GO:1901360,GO:1901564,GO:1901698,GO:1901700,GO:1902494,GO:1990204	1.6.5.3	ko:K03883	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_230703_7	7176.CPIJ040083-PA	9.83e-189	524.0	COG1845@1|root,KOG4664@2759|Eukaryota,39ASV@33154|Opisthokonta,3BF9J@33208|Metazoa,3CUZX@33213|Bilateria,420NY@6656|Arthropoda,3SM4Z@50557|Insecta,44XZ9@7147|Diptera,45F7R@7148|Nematocera	33208|Metazoa	C	Subunits I, II and III form the functional core of the enzyme complex	COX3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0008150,GO:0008535,GO:0009987,GO:0016020,GO:0016043,GO:0017004,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045277,GO:0065003,GO:0070069,GO:0070469,GO:0071840,GO:0098796,GO:0098803	-	ko:K02262	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX3
k59_230703_8	7159.AAEL018668-PA	3.73e-141	400.0	COG0356@1|root,KOG4665@2759|Eukaryota,38D9B@33154|Opisthokonta,3BKF8@33208|Metazoa,3CY1J@33213|Bilateria,421T9@6656|Arthropoda,3SP42@50557|Insecta,452VJ@7147|Diptera,45E6G@7148|Nematocera	33208|Metazoa	C	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel	ATP6	GO:0000276,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006839,GO:0006996,GO:0007005,GO:0007006,GO:0007007,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008324,GO:0008340,GO:0008553,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010259,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016043,GO:0016310,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019866,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040011,GO:0042407,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0042776,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046716,GO:0046907,GO:0046933,GO:0048856,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0055086,GO:0060249,GO:0061024,GO:0065007,GO:0065008,GO:0070050,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:1990542	-	ko:K02126	ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016	M00158	-	-	ko00000,ko00001,ko00002,ko03029	3.A.2.1	-	-	ATP-synt_A
k59_230703_9	7159.AAEL018664-PA	6.05e-144	408.0	COG1622@1|root,KOG4767@2759|Eukaryota,38FF8@33154|Opisthokonta,3BEBX@33208|Metazoa,3D20G@33213|Bilateria,421PU@6656|Arthropoda,3SMHI@50557|Insecta,44Z4Z@7147|Diptera,45GI0@7148|Nematocera	33208|Metazoa	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1	COX2	GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006140,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006979,GO:0007275,GO:0007589,GO:0007595,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010310,GO:0010562,GO:0010726,GO:0010728,GO:0010729,GO:0010939,GO:0010940,GO:0010941,GO:0010942,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0017144,GO:0019219,GO:0019220,GO:0019222,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0030808,GO:0030810,GO:0030879,GO:0031090,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0045935,GO:0045937,GO:0045981,GO:0046034,GO:0046483,GO:0046903,GO:0048513,GO:0048518,GO:0048522,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050794,GO:0050878,GO:0050896,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051194,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0080090,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1900371,GO:1900373,GO:1900542,GO:1900544,GO:1901135,GO:1901360,GO:1901564,GO:1902600,GO:1903426,GO:1903428,GO:1903578,GO:1903580,GO:2000377,GO:2000379,GO:2001169,GO:2001171	-	ko:K02261	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX2,COX2_TM
k59_230703_10	7159.AAEL018662-PA	1.13e-219	615.0	COG0843@1|root,KOG4769@2759|Eukaryota,38JQ7@33154|Opisthokonta,3BGCX@33208|Metazoa,3CVN2@33213|Bilateria,4207B@6656|Arthropoda,3SKVF@50557|Insecta,452PZ@7147|Diptera,45CHG@7148|Nematocera	33208|Metazoa	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	COX1	GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005750,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006979,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007568,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009628,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0021549,GO:0022037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0030902,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032991,GO:0034220,GO:0034641,GO:0042221,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045275,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0046686,GO:0046688,GO:0048513,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051597,GO:0051602,GO:0055085,GO:0055086,GO:0055114,GO:0060322,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902600,GO:1990204	1.9.3.1	ko:K02256	ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016	M00154	-	-	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.4.11,3.D.4.7,3.D.4.8	-	-	COX1,COX2
k59_230703_11	7159.AAEL018658-PA	5.7e-79	244.0	COG1007@1|root,KOG4668@2759|Eukaryota,3940U@33154|Opisthokonta,3BFHH@33208|Metazoa,3D425@33213|Bilateria,423E9@6656|Arthropoda,3SPZ4@50557|Insecta,450IM@7147|Diptera,45G9I@7148|Nematocera	33208|Metazoa	C	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	ND2	GO:0003674,GO:0003824,GO:0003954,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010257,GO:0014069,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032279,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0035254,GO:0035255,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044456,GO:0044464,GO:0045202,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0072593,GO:0097458,GO:0098794,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0098984,GO:0099572,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K03879	ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012	M00142	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko03029	3.D.1.6	-	-	NADH_dehy_S2_C,Proton_antipo_M
k59_101143_1	1236908.wNo_05900	1.23e-13	68.2	COG3637@1|root,COG3637@2|Bacteria,1NGKR@1224|Proteobacteria,2UGKC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,Surface_Ag_2
k59_101143_2	570417.WP0936	2.83e-30	114.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,47F1S@766|Rickettsiales	766|Rickettsiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_51519_1	436308.Nmar_0490	1.84e-86	267.0	COG0001@1|root,arCOG00918@2157|Archaea,41SDE@651137|Thaumarchaeota	651137|Thaumarchaeota	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_181227_1	1265313.HRUBRA_02422	1.28e-30	114.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria	2|Bacteria	P	Na H antiporter, MnhB	mnhB	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB
k59_181227_2	1345697.M493_15275	1.08e-10	61.2	COG1320@1|root,COG1320@2|Bacteria,1VABT@1239|Firmicutes,4HPZU@91061|Bacilli,1WGRR@129337|Geobacillus	91061|Bacilli	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_181227_3	1265313.HRUBRA_02420	7.84e-34	118.0	COG2212@1|root,COG2212@2|Bacteria,1N2PU@1224|Proteobacteria	1224|Proteobacteria	P	Pfam Multiple resistance and pH regulation protein F	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
k59_51520_1	1323663.AROI01000006_gene2818	2.15e-60	204.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RRF5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS,dCache_1
k59_121374_1	436308.Nmar_1080	1.93e-44	145.0	COG1436@1|root,arCOG04102@2157|Archaea,41T76@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ATP synthase (F/14-kDa) subunit	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
k59_121374_2	1229909.NSED_06295	1.85e-27	101.0	arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_31705_1	388413.ALPR1_03145	3.19e-09	60.5	COG0673@1|root,COG0673@2|Bacteria,4NEQB@976|Bacteroidetes,47KWZ@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.371	ko:K16044	ko00562,ko01120,map00562,map01120	-	R09954	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_31705_2	1120956.JHZK01000002_gene996	9.7e-58	186.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	dddQ	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,DUF4437
k59_1463_2	330214.NIDE1095	4.19e-26	104.0	COG0502@1|root,COG0502@2|Bacteria,3J0I9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_41644_1	228410.NE2374	8.61e-74	246.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales	28216|Betaproteobacteria	C	dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_240614_1	570417.WP0831	2.7e-217	618.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,47EVH@766|Rickettsiales	766|Rickettsiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_21597_1	7668.SPU_003512-tr	2.5e-22	99.4	KOG1075@1|root,KOG1075@2759|Eukaryota,3A32Z@33154|Opisthokonta	2759|Eukaryota	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_121385_1	7029.ACYPI009216-PA	1.44e-54	199.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_261064_1	7213.XP_004520919.1	4.37e-34	134.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,4556V@7147|Diptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_250948_1	1227457.C451_05925	3.05e-25	116.0	COG3436@1|root,arCOG04792@2157|Archaea,2XTVF@28890|Euryarchaeota,23U2Z@183963|Halobacteria	183963|Halobacteria	L	COG3436 Transposase and inactivated derivatives	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k59_171327_1	436308.Nmar_1622	2.04e-99	298.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_111459_1	631362.Thi970DRAFT_01008	3.16e-64	219.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_1496_1	330214.NIDE3575	1.32e-89	273.0	COG0717@1|root,COG0717@2|Bacteria,3J0WG@40117|Nitrospirae	40117|Nitrospirae	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
k59_250964_1	436308.Nmar_1627	3.04e-195	566.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_121398_1	469382.Hbor_15680	2.5e-28	112.0	COG0665@1|root,arCOG00755@2157|Archaea,2XUM9@28890|Euryarchaeota,23S19@183963|Halobacteria	183963|Halobacteria	E	COG0665 Glycine D-amino acid oxidases (deaminating)	solA	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_211072_1	1122236.KB905141_gene1334	9.21e-73	244.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG4627@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,COG4627@2|Bacteria,1RBR3@1224|Proteobacteria,2VSKQ@28216|Betaproteobacteria,2KP39@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_71102_1	1144312.PMI09_01779	9.93e-104	307.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,4BMJ8@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_51563_1	1229909.NSED_04675	2.81e-99	301.0	COG1171@1|root,arCOG01431@2157|Archaea,41SCU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_131566_1	864051.BurJ1DRAFT_4934	1.32e-06	52.4	COG0640@1|root,COG0640@2|Bacteria,1RIJ9@1224|Proteobacteria,2VTID@28216|Betaproteobacteria,1KP8P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_201230_1	436308.Nmar_0114	5.38e-89	267.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,TrmB
k59_201230_2	1229909.NSED_00265	3.73e-89	263.0	COG1321@1|root,arCOG02100@2157|Archaea,41SIJ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
k59_221026_1	1207063.P24_04989	5.35e-61	201.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,2JQ7C@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_280802_1	7159.AAEL007152-PA	7.57e-12	71.6	COG5147@1|root,KOG0049@2759|Eukaryota,38YRX@33154|Opisthokonta,3BE5I@33208|Metazoa,3CVK5@33213|Bilateria,41Z8B@6656|Arthropoda,3SMVD@50557|Insecta,44Z1D@7147|Diptera,45EWH@7148|Nematocera	33208|Metazoa	K	Myb-like DNA-binding domain	SNAPC4	GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0000988,GO:0000989,GO:0000992,GO:0001006,GO:0001012,GO:0001016,GO:0001032,GO:0001067,GO:0001076,GO:0001134,GO:0001135,GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006383,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009301,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016043,GO:0016070,GO:0016073,GO:0018130,GO:0019185,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0030154,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032502,GO:0032774,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042795,GO:0042796,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043565,GO:0043933,GO:0044085,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044798,GO:0046483,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098781,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141	-	ko:K09453	-	-	-	-	ko00000,ko03000,ko03021	-	-	-	Myb_DNA-bind_6,Myb_DNA-binding
k59_141330_2	7029.ACYPI56814-PA	1.05e-47	173.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3DE2J@33213|Bilateria	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_310688_1	1229909.NSED_09340	1.58e-96	294.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
k59_310698_1	1038860.AXAP01000007_gene6037	4.62e-55	185.0	COG0189@1|root,COG0189@2|Bacteria,1NX9V@1224|Proteobacteria,2TU7A@28211|Alphaproteobacteria,3JSIX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_141355_1	522306.CAP2UW1_1793	2.6e-85	262.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria	1224|Proteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_101232_1	7159.AAEL017192-PA	7.99e-76	253.0	COG3119@1|root,KOG3867@2759|Eukaryota,38DVH@33154|Opisthokonta,3BAP3@33208|Metazoa,3CRD5@33213|Bilateria,41UDF@6656|Arthropoda,3SK1D@50557|Insecta,44XV5@7147|Diptera,45CWX@7148|Nematocera	33208|Metazoa	P	Sulfatase	-	-	3.1.6.12	ko:K01135	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
k59_81761_1	1236908.wNo_11100	1.02e-58	196.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,47F05@766|Rickettsiales	766|Rickettsiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
k59_41747_1	7029.ACYPI50219-PA	4.82e-39	156.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_311518_2	1038859.AXAU01000002_gene322	2.6e-31	119.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,3JSAU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_101990_1	570417.WP0610	4.4e-98	285.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,47FC7@766|Rickettsiales	766|Rickettsiales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_101990_2	570417.WP0611	3.43e-49	159.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,47FEQ@766|Rickettsiales	766|Rickettsiales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_281711_1	1236908.wNo_07520	6.65e-149	424.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,47EYB@766|Rickettsiales	766|Rickettsiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_32826_2	1541065.JRFE01000007_gene5069	1.9e-19	93.6	COG0121@1|root,COG0121@2|Bacteria,1G0IW@1117|Cyanobacteria,3VM1Y@52604|Pleurocapsales	1117|Cyanobacteria	S	Glutamine amidotransferases class-II	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0032991,GO:0034641,GO:0042219,GO:0043171,GO:0043603,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0051186,GO:0051187,GO:0061672,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368	-	-	-	-	-	-	-	-	-	-	GATase_4,GATase_6
k59_32826_3	675635.Psed_0296	0.000266	43.5	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DYSZ@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	2.8.3.15,2.8.3.16,2.8.3.19	ko:K07544,ko:K07749,ko:K18702	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05588	RC00014,RC00137	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_292007_1	1229909.NSED_01265	9.03e-165	472.0	COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Carbamoyl-phosphate synthase L chain	-	-	6.4.1.2,6.4.1.3	ko:K18603	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
k59_82843_2	375286.mma_3098	8.86e-45	150.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,474CZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	NUDIX domain	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
k59_62509_1	330214.NIDE1299	1.02e-77	234.0	COG0250@1|root,COG0250@2|Bacteria,3J0JA@40117|Nitrospirae	40117|Nitrospirae	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_62509_2	330214.NIDE1300	7.1e-30	108.0	COG0080@1|root,COG0080@2|Bacteria,3J0K2@40117|Nitrospirae	40117|Nitrospirae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_32843_1	1123401.JHYQ01000006_gene36	0.000227	43.1	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,45ZPM@72273|Thiotrichales	72273|Thiotrichales	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_272130_1	7029.ACYPI50162-PA	2.01e-24	107.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_42895_1	1236908.wNo_06230	1.19e-146	429.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,47EYM@766|Rickettsiales	766|Rickettsiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_142346_1	5507.FOXG_17759P0	5.98e-40	162.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A50K@33154|Opisthokonta,3P4T5@4751|Fungi,3QYV3@4890|Ascomycota,21EBC@147550|Sordariomycetes,3TKYE@5125|Hypocreales,1FUQK@110618|Nectriaceae	4751|Fungi	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_202276_1	1439940.BAY1663_00266	2.1e-08	54.3	COG0466@1|root,COG1219@1|root,COG0466@2|Bacteria,COG1219@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_202276_2	1288494.EBAPG3_26770	9.11e-116	335.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,371RU@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_132722_1	570417.WP0906	8.44e-276	768.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,47F86@766|Rickettsiales	766|Rickettsiales	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
k59_82869_1	436308.Nmar_0618	3.4e-96	305.0	COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_306474_1	7070.TC011220-PA	2.99e-37	146.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_278993_1	477184.KYC_09846	5.01e-05	50.8	COG4521@1|root,COG4521@2|Bacteria,1QVY3@1224|Proteobacteria,2VN3S@28216|Betaproteobacteria,3T2RS@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC transporter substrate-binding protein	-	-	-	ko:K15551	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	NMT1
k59_59809_1	7176.CPIJ019125-PA	1.97e-15	78.2	COG1131@1|root,KOG0061@2759|Eukaryota,38CVQ@33154|Opisthokonta,3BMMP@33208|Metazoa,3D2T5@33213|Bilateria,41X63@6656|Arthropoda,3SIBB@50557|Insecta,4510V@7147|Diptera,45H0R@7148|Nematocera	33208|Metazoa	Q	ABC-2 type transporter	-	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015248,GO:0015318,GO:0015399,GO:0015405,GO:0015850,GO:0015918,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017127,GO:0022804,GO:0022857,GO:0030301,GO:0031224,GO:0033036,GO:0034040,GO:0034041,GO:0042623,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1901618	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran
k59_199288_1	436308.Nmar_1036	2.13e-57	181.0	arCOG08725@1|root,arCOG08725@2157|Archaea,41T3W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_199288_2	273075.Ta1148	4.31e-07	50.8	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,241JJ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k59_246939_1	10224.XP_006822105.1	6.19e-52	180.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10577	ko03013,ko04064,ko04120,ko05206,map03013,map04064,map04120,map05206	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko04121	-	-	-	RVT_1
k59_199313_1	330214.NIDE3475	4.06e-65	211.0	COG0845@1|root,COG0845@2|Bacteria,3J10X@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
k59_287527_1	90675.XP_010431066.1	8.38e-70	259.0	COG2801@1|root,KOG0017@2759|Eukaryota,37RKH@33090|Viridiplantae,3GGZK@35493|Streptophyta,3HZ1D@3699|Brassicales	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	ATHILA,RVT_1,Retrotrans_gag,rve
k59_219025_1	7213.XP_004520462.1	7.91e-38	145.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,453HV@7147|Diptera	33208|Metazoa	L	It is involved in the biological process described with	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_179062_1	570417.WP1128	7.8e-126	360.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2U1Y2@28211|Alphaproteobacteria,47FMG@766|Rickettsiales	766|Rickettsiales	H	Uroporphyrinogen-III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
k59_219026_1	28377.ENSACAP00000022290	2.12e-58	205.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BGB6@33208|Metazoa,3E4E9@33213|Bilateria,48KK2@7711|Chordata,49MPT@7742|Vertebrata	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve
k59_279041_1	110662.Syncc9605_2524	3.12e-34	135.0	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1GZV9@1129|Synechococcus	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,Peptidase_M10_C
k59_287529_1	1229909.NSED_08190	1.21e-118	358.0	COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota	651137|Thaumarchaeota	J	phenylalanyl-tRNA synthetase, beta subunit	-	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
k59_128798_2	697303.Thewi_0765	6.3e-33	130.0	COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,42G1G@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
k59_317903_1	1267535.KB906767_gene2031	6.01e-66	211.0	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	2|Bacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
k59_208582_1	7425.NV30389-PA	6.23e-26	104.0	2F3G8@1|root,2T4FJ@2759|Eukaryota,38Y72@33154|Opisthokonta,3C5TK@33208|Metazoa,3DM4J@33213|Bilateria,42320@6656|Arthropoda	7425.NV30389-PA|-	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_229105_1	335283.Neut_2331	5.72e-142	418.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,371Z6@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_8499_1	1236908.wNo_01650	2.33e-73	227.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,47FGA@766|Rickettsiales	766|Rickettsiales	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_8499_2	570417.WP0498	1.38e-84	249.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,47FKH@766|Rickettsiales	766|Rickettsiales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
k59_236683_1	1236908.wNo_07560	5.91e-286	785.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,47EXA@766|Rickettsiales	766|Rickettsiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k59_118675_1	1255043.TVNIR_3244	1.09e-142	407.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_8502_1	1265503.KB905183_gene4403	1.21e-21	90.1	COG3791@1|root,COG3791@2|Bacteria,1N7AZ@1224|Proteobacteria,1SDYM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
k59_8502_2	748247.AZKH_p0041	2.24e-27	106.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_118681_1	1236908.wNo_09280	7.65e-21	88.6	COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,2TVXP@28211|Alphaproteobacteria,47FCA@766|Rickettsiales	766|Rickettsiales	P	cation ABC transporter, periplasmic cation-binding protein	znuA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k59_298978_1	545264.KB898752_gene2318	3.47e-33	124.0	COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,1SQRV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
k59_118687_1	266265.Bxe_C0542	1.81e-96	287.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2VH1V@28216|Betaproteobacteria,1K3TN@119060|Burkholderiaceae	28216|Betaproteobacteria	K	CRP FNR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
k59_148894_1	400682.PAC_15703323	2.34e-35	137.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_247009_1	1229909.NSED_08020	2.36e-67	217.0	COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	adenylosuccinate lyase	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k59_247009_2	1131266.ARWQ01000001_gene1085	2.91e-15	75.1	COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_77150_1	570417.WP1276	2e-124	380.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,47EXC@766|Rickettsiales	766|Rickettsiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_236714_1	7425.NV18588-PA	6.86e-67	231.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_306585_1	1236908.wNo_05580	1.09e-42	149.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,47F1R@766|Rickettsiales	766|Rickettsiales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
k59_287628_1	1123401.JHYQ01000005_gene320	2.34e-22	93.6	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,1S459@1236|Gammaproteobacteria,463TA@72273|Thiotrichales	72273|Thiotrichales	K	MerR, DNA binding	-	-	-	ko:K08365	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
k59_8551_2	1096546.WYO_3593	5.59e-36	135.0	COG2303@1|root,COG2303@2|Bacteria,1MUK2@1224|Proteobacteria,2U08V@28211|Alphaproteobacteria,1JTFM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM glucose-methanol-choline oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
k59_29342_1	69319.XP_008548388.1	2.66e-46	172.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VTV@33154|Opisthokonta,3C62P@33208|Metazoa,3DERR@33213|Bilateria,42CJK@6656|Arthropoda,3STG0@50557|Insecta,46KPV@7399|Hymenoptera	33208|Metazoa	OU	Zinc knuckle	-	-	-	-	-	-	-	-	-	-	-	-	zf-CCHC
k59_118724_1	1236908.wNo_01030	1.29e-119	382.0	COG0457@1|root,COG0666@1|root,COG1672@1|root,COG2931@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG1672@2|Bacteria,COG2931@2|Bacteria,1MWRF@1224|Proteobacteria,2U9VQ@28211|Alphaproteobacteria,47F2N@766|Rickettsiales	766|Rickettsiales	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5,GerE,NB-ARC,TPR_12,TPR_2,TPR_7,TPR_8
k59_129868_2	1120949.KB903294_gene4217	2.96e-05	46.6	COG0596@1|root,COG0596@2|Bacteria,2IAKH@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
k59_159814_1	292459.STH2811	3.09e-34	127.0	COG3324@1|root,COG3324@2|Bacteria,1VD9A@1239|Firmicutes	1239|Firmicutes	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
k59_199713_1	400682.PAC_15699223	9.7e-33	128.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa	33208|Metazoa	OU	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_279479_1	570417.WP1242	5.23e-34	119.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,47FKT@766|Rickettsiales	766|Rickettsiales	U	The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF- YajC-YidC subcomplex facilitates these functions	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k59_279479_2	570417.WP1241	1.29e-56	191.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,47EW3@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_80028_1	1236908.wNo_00180	8.83e-152	434.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,47F53@766|Rickettsiales	766|Rickettsiales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_229663_1	94624.Bpet4350	1.46e-62	203.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,3T51C@506|Alcaligenaceae	28216|Betaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_139847_1	1187848.AJYQ01000152_gene2365	4.45e-43	152.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1XSQB@135623|Vibrionales	135623|Vibrionales	C	Part of a membrane complex involved in electron transport	rnfD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
k59_269477_2	977880.RALTA_A3049	1.08e-34	122.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
k59_309444_1	7213.XP_004529993.1	1.75e-49	172.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,4224M@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_10182_1	570417.WP0983	5.2e-292	798.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,47EUJ@766|Rickettsiales	766|Rickettsiales	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_209694_1	557598.LHK_02562	2.01e-44	149.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,2KRC6@206351|Neisseriales	206351|Neisseriales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k59_299425_1	7159.AAEL001147-PA	7.76e-10	65.1	KOG1844@1|root,KOG1844@2759|Eukaryota,38E5M@33154|Opisthokonta,3BCJN@33208|Metazoa,3CZU3@33213|Bilateria,41V9T@6656|Arthropoda,3SGUU@50557|Insecta,44YVX@7147|Diptera,45BU2@7148|Nematocera	33208|Metazoa	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	KMT2E	GO:0000785,GO:0001775,GO:0002252,GO:0002262,GO:0002274,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002520,GO:0002682,GO:0003674,GO:0003682,GO:0003712,GO:0003713,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005700,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006325,GO:0006342,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007346,GO:0007568,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008340,GO:0008757,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010259,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010638,GO:0016043,GO:0016278,GO:0016279,GO:0016458,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018024,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019538,GO:0019899,GO:0023052,GO:0030097,GO:0030099,GO:0030154,GO:0030218,GO:0030522,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0032259,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032991,GO:0033043,GO:0033044,GO:0034101,GO:0034401,GO:0034641,GO:0034968,GO:0035064,GO:0035065,GO:0035327,GO:0036124,GO:0036211,GO:0036230,GO:0040029,GO:0042054,GO:0042119,GO:0042393,GO:0042592,GO:0042800,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0044728,GO:0045321,GO:0045595,GO:0045637,GO:0045652,GO:0045787,GO:0045814,GO:0045892,GO:0045893,GO:0045931,GO:0045934,GO:0045935,GO:0046483,GO:0046974,GO:0048384,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0048872,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051567,GO:0051568,GO:0051569,GO:0051571,GO:0051716,GO:0051726,GO:0060255,GO:0061647,GO:0065007,GO:0065008,GO:0070013,GO:0070828,GO:0070868,GO:0071704,GO:0071840,GO:0080090,GO:0090068,GO:0090304,GO:0097549,GO:0140030,GO:0140034,GO:0140096,GO:0140110,GO:1900087,GO:1901360,GO:1901564,GO:1901983,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902275,GO:1902679,GO:1902680,GO:1902806,GO:1902808,GO:1903506,GO:1903507,GO:1903508,GO:1903706,GO:1905269,GO:1905435,GO:1905437,GO:2000026,GO:2000045,GO:2000112,GO:2000113,GO:2000756,GO:2001141,GO:2001252	2.1.1.43	ko:K09189	ko00310,map00310	-	R03875,R03938,R04866,R04867	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000,ko03000,ko03036	-	-	-	PHD,SET
k59_249570_1	159450.NH14_30620	6.71e-87	269.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	similarity to GP 3192745	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_219647_1	7029.ACYPI24265-PA	3.28e-18	96.3	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_219647_2	7029.ACYPI004757-PA	2.59e-75	266.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3ECWM@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_109923_1	991905.SL003B_0087	1.85e-84	268.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,4BP7M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_289524_1	1118054.CAGW01000053_gene1426	8.15e-43	160.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4HC4B@91061|Bacilli,26VFC@186822|Paenibacillaceae	91061|Bacilli	S	Tripartite ATP-independent periplasmic transporter, DctM component	siaT_4	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_149802_1	269799.Gmet_2883	1.98e-77	247.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,43BDP@68525|delta/epsilon subdivisions,2WTRS@28221|Deltaproteobacteria,43SXJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_169853_1	570417.WP1223	4.15e-137	403.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,47EVM@766|Rickettsiales	766|Rickettsiales	V	Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP- binding domain (NBD) is responsible for energy generation (By similarity)	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_309454_1	1229909.NSED_04070	5.76e-46	157.0	COG2107@1|root,arCOG00654@2157|Archaea,41SB8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
k59_30182_1	1121920.AUAU01000016_gene1339	4.26e-75	242.0	COG2804@1|root,COG2804@2|Bacteria,3Y2IS@57723|Acidobacteria	57723|Acidobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
k59_246_1	1207063.P24_00985	2.07e-13	69.3	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2JRYT@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_309461_2	7425.NV21107-PA	1.68e-10	65.9	KOG4585@1|root,KOG4585@2759|Eukaryota,3AU2M@33154|Opisthokonta,3C4SK@33208|Metazoa,3DJIS@33213|Bilateria,4278S@6656|Arthropoda,3SX2Z@50557|Insecta,46MEB@7399|Hymenoptera	2759|Eukaryota	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4
k59_189782_1	570417.WP0328	5.66e-164	463.0	28H75@1|root,2Z7JG@2|Bacteria,1MU3Y@1224|Proteobacteria,2TVB5@28211|Alphaproteobacteria,47FW2@766|Rickettsiales	766|Rickettsiales	S	Phage major capsid protein E	-	-	-	-	-	-	-	-	-	-	-	-	Phage_cap_E
k59_309462_1	243233.MCA0003	5.53e-05	44.7	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XDZ7@135618|Methylococcales	135618|Methylococcales	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
k59_309462_2	1288826.MSNKSG1_14547	1.7e-31	118.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,466SB@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
k59_50135_1	7425.NV18262-PA	1.32e-49	179.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_30193_1	1283300.ATXB01000002_gene2925	4.86e-101	314.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XE1B@135618|Methylococcales	135618|Methylococcales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
k59_90053_1	570417.WP0692	3.81e-191	537.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria,2TRFG@28211|Alphaproteobacteria,47G54@766|Rickettsiales	766|Rickettsiales	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
k59_309463_1	570417.WP0271	1.22e-100	294.0	COG1502@1|root,COG1502@2|Bacteria,1RG6H@1224|Proteobacteria,2UBNE@28211|Alphaproteobacteria,47GS4@766|Rickettsiales	28211|Alphaproteobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
k59_309463_2	1236908.wNo_10280	2.01e-130	375.0	COG3621@1|root,COG3621@2|Bacteria,1RDY7@1224|Proteobacteria,2VGM5@28211|Alphaproteobacteria,47EUB@766|Rickettsiales	766|Rickettsiales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
k59_139906_1	570417.WP0946	9.05e-123	351.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_169883_1	7029.ACYPI073273-PA	2.3e-15	83.2	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_80108_1	100901.wOo_09240	1.74e-14	69.7	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,2UCR8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_80108_2	1236908.wNo_05690	3.71e-78	241.0	COG2730@1|root,COG2730@2|Bacteria,1PJTY@1224|Proteobacteria,2TU2X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
k59_249615_1	570417.WP0120	2.45e-101	305.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2TV8B@28211|Alphaproteobacteria,47EXZ@766|Rickettsiales	766|Rickettsiales	S	2-Nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
k59_279547_1	570417.WP0140	1.53e-236	663.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,47EZM@766|Rickettsiales	766|Rickettsiales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_169893_1	7176.CPIJ012547-PA	5.16e-92	295.0	2CW45@1|root,2RTJZ@2759|Eukaryota,3961V@33154|Opisthokonta,3CAFJ@33208|Metazoa,3DRMK@33213|Bilateria,4229X@6656|Arthropoda,3SR62@50557|Insecta,4568F@7147|Diptera,45KDQ@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_199803_1	570417.WP1274	1.09e-122	356.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,47F43@766|Rickettsiales	766|Rickettsiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_129980_1	1236908.wNo_02480	1.01e-50	167.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,47F1P@766|Rickettsiales	766|Rickettsiales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_269541_1	228410.NE1876	6.17e-96	286.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,372SB@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_269541_2	287.DR97_5060	3.93e-07	54.7	COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S1WE@1236|Gammaproteobacteria,1YDAV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
k59_289570_1	1209989.TepiRe1_0702	6.95e-23	98.6	COG1027@1|root,COG1027@2|Bacteria,1TP3U@1239|Firmicutes,2483Z@186801|Clostridia,42FS1@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM fumarate lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_289570_2	436308.Nmar_1667	3.5e-39	142.0	COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
k59_159936_1	1236908.wNo_08970	1.54e-124	367.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,47F0X@766|Rickettsiales	766|Rickettsiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_30218_1	10029.XP_007634688.1	8.66e-77	250.0	COG2036@1|root,COG5262@1|root,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JGKY@40674|Mammalia,35PSM@314146|Euarchontoglires,4Q54X@9989|Rodentia	33208|Metazoa	B	Core histone H2A/H2B/H3/H4	HIST3H3	GO:0000228,GO:0000723,GO:0000726,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016233,GO:0022607,GO:0031333,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031974,GO:0031981,GO:0032200,GO:0032459,GO:0032460,GO:0032991,GO:0032993,GO:0033554,GO:0034622,GO:0034641,GO:0034728,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0044877,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051259,GO:0051262,GO:0051276,GO:0051290,GO:0051291,GO:0051716,GO:0060249,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K11253,ko:K11275	ko05034,ko05202,ko05322,map05034,map05202,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Histone
k59_30218_2	1026970.XP_008824872.1	1.22e-57	196.0	COG2036@1|root,COG5262@1|root,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,KOG3467@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JEM2@40674|Mammalia,35PS8@314146|Euarchontoglires	33208|Metazoa	B	Histone cluster 1	HIST1H3D	GO:0000228,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006335,GO:0006996,GO:0008150,GO:0009987,GO:0010468,GO:0016043,GO:0019222,GO:0022607,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0034622,GO:0034723,GO:0034728,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0044877,GO:0050789,GO:0050794,GO:0051259,GO:0051262,GO:0051276,GO:0051290,GO:0051291,GO:0060255,GO:0060968,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0071103,GO:0071824,GO:0071840,GO:0097159,GO:1901363	-	ko:K11253,ko:K11254	ko05034,ko05202,ko05203,ko05322,map05034,map05202,map05203,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	CENP-T_C,Histone,Histone_H2A_C
k59_10252_1	436308.Nmar_0382	1.13e-78	239.0	COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_279562_1	1231391.AMZF01000018_gene1832	3.9e-58	200.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VTNQ@28216|Betaproteobacteria,3T83X@506|Alcaligenaceae	28216|Betaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_249625_1	1236908.wNo_09460	1.88e-97	286.0	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,2UM11@28211|Alphaproteobacteria,47GSG@766|Rickettsiales	766|Rickettsiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_199809_1	7070.TC002212-PA	9.24e-05	52.4	COG2801@1|root,COG5082@1|root,KOG0017@2759|Eukaryota,KOG4400@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3DDWX@33213|Bilateria,42228@6656|Arthropoda,3SPN5@50557|Insecta	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVP,RVT_1,Retrotrans_gag,rve,zf-CCHC
k59_60125_1	267608.RSc0087	1.57e-11	68.6	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1K0ZM@119060|Burkholderiaceae	28216|Betaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
k59_239613_1	1236908.wNo_11070	9.34e-178	511.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,47EWH@766|Rickettsiales	766|Rickettsiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_249632_1	7994.ENSAMXP00000011172	8.27e-05	46.2	COG0457@1|root,KOG0118@1|root,KOG0118@2759|Eukaryota,KOG0548@2759|Eukaryota,39SZH@33154|Opisthokonta,3BF8D@33208|Metazoa,3CX0N@33213|Bilateria,48CMA@7711|Chordata,495ZT@7742|Vertebrata,49RZ0@7898|Actinopterygii	33208|Metazoa	O	Tetratricopeptide repeat domain 31	TTC31	-	-	-	-	-	-	-	-	-	-	-	RRM_1,TPR_16,TPR_2,TPR_8
k59_249632_2	1089552.KI911559_gene624	2.08e-23	91.3	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2JTV9@204441|Rhodospirillales	204441|Rhodospirillales	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_279571_1	436308.Nmar_1004	2.95e-37	138.0	COG0405@1|root,arCOG04053@2157|Archaea	2157|Archaea	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_279571_2	436308.Nmar_1008	5.06e-31	121.0	COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea	2157|Archaea	EF	ATP-grasp domain	cxp2	-	3.4.17.11,3.5.1.18,6.3.2.4	ko:K01295,ko:K01439,ko:K01921,ko:K16181	ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502	M00016	R01150,R02734,R10011	RC00064,RC00090,RC00096,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011	-	-	-	ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20
k59_30219_2	1828.JOKB01000001_gene15	4.88e-06	51.2	2BD0A@1|root,326MH@2|Bacteria,2HKHE@201174|Actinobacteria,4G8C4@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_299474_1	6087.XP_004206654.1	2.27e-56	211.0	2CNQC@1|root,2QXFF@2759|Eukaryota,39Y03@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_219726_2	522306.CAP2UW1_1324	5.88e-33	129.0	COG0543@1|root,COG1018@1|root,COG1290@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,COG1290@2|Bacteria,1MV72@1224|Proteobacteria,2VI6M@28216|Betaproteobacteria,1KR75@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FAD_binding_6,Fer2,NAD_binding_1
k59_40195_1	7159.AAEL017571-PA	8.97e-56	203.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_159969_1	323848.Nmul_A1295	1.4e-38	137.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,37275@32003|Nitrosomonadales	28216|Betaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_159969_2	1212548.B381_05151	4.63e-25	97.1	COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,1Z3AA@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	COG2963 Transposase and inactivated derivatives	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_80167_1	436308.Nmar_0445	2.32e-53	187.0	COG1196@1|root,arCOG00371@2157|Archaea,41T1Y@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Required for chromosome condensation and partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_90122_1	1229909.NSED_09410	5.83e-89	273.0	COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_150391_1	228410.NE2093	1.33e-14	75.5	COG2519@1|root,COG2519@2|Bacteria	2|Bacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,Methyltransf_24
k59_218704_1	744979.R2A130_3657	6.58e-57	185.0	COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,2TQNU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_258389_1	1236908.wNo_04650	1.6e-111	321.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,47FMV@766|Rickettsiales	766|Rickettsiales	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
k59_189358_1	400682.PAC_15708465	2.76e-23	107.0	29YJV@1|root,2RXU5@2759|Eukaryota,3A0FB@33154|Opisthokonta,3BPYT@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_39671_1	1163617.SCD_n00156	9.67e-58	186.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,2VJ7R@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Transport permease protein	nodJ	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
k59_39671_2	375286.mma_3383	9.16e-12	64.3	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,476I6@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
k59_49769_1	261292.Nit79A3_0779	4.17e-81	248.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,371SI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	cAMP phosphodiesterases class-II	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_189376_1	163164.WD_1251	1.81e-24	97.1	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,47FAN@766|Rickettsiales	766|Rickettsiales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_278743_1	595537.Varpa_1279	5.64e-46	153.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,4AAIY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_278743_2	713587.THITH_14555	1.03e-67	219.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1WWQP@135613|Chromatiales	135613|Chromatiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_236453_1	1131266.ARWQ01000008_gene330	3.24e-166	469.0	COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_199033_1	31234.CRE02412	7.71e-62	214.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,40S01@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_8225_1	7260.FBpp0249411	1.04e-32	126.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_208291_1	485916.Dtox_2239	4.58e-13	69.7	28J8Y@1|root,2Z943@2|Bacteria,1UKQN@1239|Firmicutes,25G19@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_189388_1	587753.EY04_00505	4.74e-08	61.2	COG0715@1|root,COG0715@2|Bacteria,1R4XP@1224|Proteobacteria,1RY7F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Nitrate ABC transporter substrate-binding protein	atsR	-	-	ko:K15553	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.2	-	-	NMT1
k59_208296_1	666685.R2APBS1_0334	3.83e-09	55.8	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,1SJPR@1236|Gammaproteobacteria,1X3U2@135614|Xanthomonadales	135614|Xanthomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
k59_208296_2	1245469.S58_65990	2.49e-28	103.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3K084@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	QU41_19825	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_258422_1	261292.Nit79A3_1075	6.04e-129	376.0	COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_218751_1	1236908.wNo_02870	2.09e-99	293.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,47EUZ@766|Rickettsiales	766|Rickettsiales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ctrA	-	-	ko:K02483,ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
k59_59604_1	1265310.CCBD010000023_gene4290	9.42e-19	86.3	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.14.14.12	ko:K16047	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
k59_317611_1	570417.WP0879	8.15e-229	635.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
k59_317611_2	570417.WP0877	7.25e-83	245.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,47FHD@766|Rickettsiales	766|Rickettsiales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
k59_317611_3	570417.WP0876	1.33e-103	302.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,47F7F@766|Rickettsiales	766|Rickettsiales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_107482_1	1121127.JAFA01000031_gene4654	2.04e-24	103.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,1K4VW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_208317_1	10224.XP_002740159.1	1.57e-33	132.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria	33208|Metazoa	G	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve,zf-H2C2
k59_258440_1	7029.ACYPI35745-PA	3.23e-49	181.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D7RZ@33213|Bilateria,422E1@6656|Arthropoda,3SQZA@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_199070_1	7425.NV10089-PA	3.52e-71	251.0	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_278789_1	7029.ACYPI56861-PA	4.33e-29	121.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Glycoprotein_B,RVT_1,Retrotrans_gag,gag-asp_proteas,rve,zf-H2C2
k59_18975_1	766499.C357_22955	7.64e-57	187.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_306335_1	1297569.MESS2_870009	1.66e-28	112.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_306335_2	1366050.N234_35820	1.15e-14	75.1	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1N5WI@1224|Proteobacteria,2VHUB@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_228828_1	7159.AAEL017224-PA	2.45e-21	96.3	COG2453@1|root,KOG2283@2759|Eukaryota,38CHA@33154|Opisthokonta,3BARF@33208|Metazoa,3CRCD@33213|Bilateria,41WWE@6656|Arthropoda,3SKKS@50557|Insecta,44ZB4@7147|Diptera,45I57@7148|Nematocera	33208|Metazoa	T	phosphatase activity. It is involved in the biological process described with protein dephosphorylation	PTEN	GO:0000003,GO:0000079,GO:0000902,GO:0000904,GO:0001525,GO:0001558,GO:0001568,GO:0001654,GO:0001655,GO:0001666,GO:0001667,GO:0001709,GO:0001745,GO:0001751,GO:0001754,GO:0001932,GO:0001933,GO:0001934,GO:0001944,GO:0001952,GO:0001953,GO:0001964,GO:0002020,GO:0002064,GO:0002065,GO:0002066,GO:0002119,GO:0002164,GO:0002165,GO:0002168,GO:0002252,GO:0002376,GO:0002682,GO:0002902,GO:0003006,GO:0003008,GO:0003674,GO:0003779,GO:0003824,GO:0004438,GO:0004721,GO:0004722,GO:0004725,GO:0005102,GO:0005161,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0006066,GO:0006355,GO:0006464,GO:0006469,GO:0006470,GO:0006508,GO:0006582,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006914,GO:0006928,GO:0006935,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007009,GO:0007010,GO:0007154,GO:0007162,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007267,GO:0007268,GO:0007270,GO:0007272,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007346,GO:0007399,GO:0007409,GO:0007416,GO:0007417,GO:0007420,GO:0007423,GO:0007424,GO:0007425,GO:0007431,GO:0007435,GO:0007436,GO:0007507,GO:0007525,GO:0007552,GO:0007568,GO:0007610,GO:0007611,GO:0007613,GO:0007617,GO:0007618,GO:0007622,GO:0007623,GO:0007626,GO:0007635,GO:0008092,GO:0008104,GO:0008138,GO:0008150,GO:0008152,GO:0008283,GO:0008284,GO:0008285,GO:0008340,GO:0008360,GO:0008361,GO:0008366,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009266,GO:0009408,GO:0009605,GO:0009628,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009898,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0010001,GO:0010033,GO:0010243,GO:0010256,GO:0010259,GO:0010468,GO:0010469,GO:0010506,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010631,GO:0010632,GO:0010633,GO:0010646,GO:0010647,GO:0010648,GO:0010660,GO:0010661,GO:0010662,GO:0010663,GO:0010665,GO:0010666,GO:0010717,GO:0010719,GO:0010720,GO:0010721,GO:0010769,GO:0010771,GO:0010810,GO:0010812,GO:0010883,GO:0010888,GO:0010941,GO:0010942,GO:0010948,GO:0010959,GO:0010975,GO:0010977,GO:0010997,GO:0014003,GO:0014066,GO:0014067,GO:0014706,GO:0016020,GO:0016043,GO:0016055,GO:0016202,GO:0016311,GO:0016314,GO:0016324,GO:0016358,GO:0016477,GO:0016579,GO:0016787,GO:0016788,GO:0016791,GO:0018958,GO:0019098,GO:0019216,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019637,GO:0019748,GO:0019751,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019953,GO:0021537,GO:0021542,GO:0021543,GO:0021700,GO:0021761,GO:0021766,GO:0021782,GO:0021953,GO:0021954,GO:0021955,GO:0022008,GO:0022010,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022612,GO:0022898,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030030,GO:0030036,GO:0030100,GO:0030154,GO:0030155,GO:0030162,GO:0030165,GO:0030182,GO:0030198,GO:0030258,GO:0030308,GO:0030334,GO:0030336,GO:0030424,GO:0030425,GO:0030534,GO:0030707,GO:0030850,GO:0030855,GO:0030900,GO:0031099,GO:0031102,GO:0031104,GO:0031175,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031329,GO:0031331,GO:0031344,GO:0031345,GO:0031396,GO:0031398,GO:0031399,GO:0031400,GO:0031401,GO:0031641,GO:0031642,GO:0031644,GO:0031645,GO:0031646,GO:0031647,GO:0031657,GO:0031658,GO:0031667,GO:0031974,GO:0031981,GO:0032006,GO:0032007,GO:0032101,GO:0032102,GO:0032103,GO:0032228,GO:0032268,GO:0032269,GO:0032270,GO:0032286,GO:0032291,GO:0032386,GO:0032388,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032989,GO:0032990,GO:0033032,GO:0033036,GO:0033157,GO:0033554,GO:0033555,GO:0033673,GO:0034593,GO:0034594,GO:0034613,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0035006,GO:0035010,GO:0035011,GO:0035069,GO:0035176,GO:0035206,GO:0035212,GO:0035239,GO:0035254,GO:0035255,GO:0035265,GO:0035272,GO:0035295,GO:0035335,GO:0035556,GO:0035690,GO:0035749,GO:0036211,GO:0036293,GO:0036294,GO:0036477,GO:0040007,GO:0040008,GO:0040011,GO:0040012,GO:0040013,GO:0040014,GO:0040015,GO:0040017,GO:0040024,GO:0042051,GO:0042052,GO:0042063,GO:0042127,GO:0042176,GO:0042221,GO:0042306,GO:0042307,GO:0042325,GO:0042326,GO:0042327,GO:0042330,GO:0042391,GO:0042440,GO:0042461,GO:0042462,GO:0042493,GO:0042552,GO:0042578,GO:0042592,GO:0042594,GO:0042711,GO:0042802,GO:0042981,GO:0042995,GO:0043005,GO:0043025,GO:0043062,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043086,GO:0043170,GO:0043197,GO:0043209,GO:0043217,GO:0043218,GO:0043220,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043266,GO:0043267,GO:0043269,GO:0043271,GO:0043408,GO:0043409,GO:0043410,GO:0043412,GO:0043434,GO:0043491,GO:0043542,GO:0043549,GO:0043550,GO:0043551,GO:0043553,GO:0043647,GO:0044057,GO:0044085,GO:0044087,GO:0044091,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044282,GO:0044297,GO:0044309,GO:0044320,GO:0044321,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044877,GO:0045017,GO:0045087,GO:0045165,GO:0045177,GO:0045202,GO:0045211,GO:0045471,GO:0045475,GO:0045595,GO:0045596,GO:0045597,GO:0045664,GO:0045665,GO:0045666,GO:0045732,GO:0045736,GO:0045786,GO:0045792,GO:0045806,GO:0045833,GO:0045843,GO:0045859,GO:0045862,GO:0045926,GO:0045930,GO:0045936,GO:0045937,GO:0046164,GO:0046174,GO:0046434,GO:0046474,GO:0046486,GO:0046488,GO:0046530,GO:0046620,GO:0046621,GO:0046626,GO:0046627,GO:0046677,GO:0046822,GO:0046824,GO:0046838,GO:0046839,GO:0046855,GO:0046856,GO:0048008,GO:0048167,GO:0048468,GO:0048477,GO:0048511,GO:0048512,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048580,GO:0048582,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048592,GO:0048608,GO:0048609,GO:0048634,GO:0048635,GO:0048638,GO:0048640,GO:0048646,GO:0048660,GO:0048662,GO:0048666,GO:0048667,GO:0048679,GO:0048681,GO:0048699,GO:0048707,GO:0048709,GO:0048731,GO:0048732,GO:0048738,GO:0048749,GO:0048812,GO:0048813,GO:0048814,GO:0048853,GO:0048854,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0048878,GO:0050678,GO:0050680,GO:0050764,GO:0050765,GO:0050767,GO:0050768,GO:0050769,GO:0050770,GO:0050771,GO:0050773,GO:0050774,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050803,GO:0050804,GO:0050805,GO:0050806,GO:0050807,GO:0050808,GO:0050821,GO:0050877,GO:0050890,GO:0050896,GO:0050905,GO:0050920,GO:0050921,GO:0050926,GO:0050927,GO:0051049,GO:0051050,GO:0051051,GO:0051090,GO:0051091,GO:0051093,GO:0051094,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051270,GO:0051271,GO:0051338,GO:0051347,GO:0051348,GO:0051438,GO:0051443,GO:0051547,GO:0051548,GO:0051602,GO:0051641,GO:0051674,GO:0051703,GO:0051704,GO:0051705,GO:0051716,GO:0051717,GO:0051726,GO:0051800,GO:0051893,GO:0051895,GO:0051896,GO:0051898,GO:0051960,GO:0051961,GO:0051962,GO:0052743,GO:0052744,GO:0052745,GO:0052866,GO:0055021,GO:0055022,GO:0055024,GO:0055026,GO:0055088,GO:0060024,GO:0060033,GO:0060043,GO:0060044,GO:0060070,GO:0060074,GO:0060134,GO:0060179,GO:0060255,GO:0060284,GO:0060291,GO:0060292,GO:0060322,GO:0060341,GO:0060420,GO:0060429,GO:0060537,GO:0060541,GO:0060548,GO:0060627,GO:0060736,GO:0060746,GO:0060996,GO:0060997,GO:0060998,GO:0061000,GO:0061001,GO:0061002,GO:0061024,GO:0061041,GO:0061045,GO:0061061,GO:0061062,GO:0061063,GO:0061065,GO:0061066,GO:0061117,GO:0061458,GO:0061564,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070228,GO:0070372,GO:0070373,GO:0070374,GO:0070482,GO:0070570,GO:0070571,GO:0070646,GO:0070647,GO:0070727,GO:0070851,GO:0070887,GO:0070925,GO:0071214,GO:0071236,GO:0071257,GO:0071310,GO:0071361,GO:0071375,GO:0071417,GO:0071453,GO:0071456,GO:0071495,GO:0071545,GO:0071704,GO:0071709,GO:0071711,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0080135,GO:0090066,GO:0090069,GO:0090071,GO:0090087,GO:0090109,GO:0090130,GO:0090132,GO:0090175,GO:0090219,GO:0090316,GO:0090342,GO:0090344,GO:0090394,GO:0090407,GO:0090596,GO:0097060,GO:0097061,GO:0097090,GO:0097105,GO:0097106,GO:0097107,GO:0097237,GO:0097305,GO:0097306,GO:0097447,GO:0097458,GO:0098552,GO:0098562,GO:0098590,GO:0098693,GO:0098698,GO:0098794,GO:0098815,GO:0098916,GO:0099054,GO:0099068,GO:0099084,GO:0099172,GO:0099173,GO:0099175,GO:0099177,GO:0099536,GO:0099537,GO:0104004,GO:0106017,GO:0106027,GO:0120025,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0140096,GO:0198738,GO:1900076,GO:1900077,GO:1900180,GO:1900182,GO:1901016,GO:1901017,GO:1901360,GO:1901379,GO:1901380,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901861,GO:1901862,GO:1901888,GO:1901889,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902041,GO:1902043,GO:1902074,GO:1902531,GO:1902532,GO:1902533,GO:1902806,GO:1902807,GO:1903034,GO:1903035,GO:1903050,GO:1903052,GO:1903121,GO:1903320,GO:1903322,GO:1903362,GO:1903364,GO:1903391,GO:1903392,GO:1903432,GO:1903506,GO:1903689,GO:1903690,GO:1903725,GO:1903726,GO:1903827,GO:1903829,GO:1903984,GO:1904029,GO:1904030,GO:1904062,GO:1904063,GO:1904262,GO:1904589,GO:1904591,GO:1904666,GO:1904668,GO:1904705,GO:1904706,GO:1904861,GO:1904951,GO:1905114,GO:1905330,GO:1905331,GO:1905809,GO:1905952,GO:1905953,GO:1990314,GO:1990381,GO:1990782,GO:2000026,GO:2000027,GO:2000045,GO:2000058,GO:2000060,GO:2000106,GO:2000112,GO:2000134,GO:2000145,GO:2000146,GO:2000171,GO:2000272,GO:2000463,GO:2000807,GO:2000808,GO:2001141,GO:2001233,GO:2001235,GO:2001236,GO:2001238	3.1.3.16,3.1.3.48,3.1.3.67	ko:K01110,ko:K18079	ko00562,ko01521,ko04068,ko04070,ko04071,ko04115,ko04140,ko04150,ko04151,ko04212,ko04218,ko04510,ko04931,ko05161,ko05165,ko05200,ko05206,ko05213,ko05214,ko05215,ko05218,ko05222,ko05224,ko05225,ko05230,map00562,map01521,map04068,map04070,map04071,map04115,map04140,map04150,map04151,map04212,map04218,map04510,map04931,map05161,map05165,map05200,map05206,map05213,map05214,map05215,map05218,map05222,map05224,map05225,map05230	-	R03363,R04513	RC00078	ko00000,ko00001,ko01000,ko01009	-	-	-	DSPc,PTEN_C2
k59_189428_2	1229909.NSED_09060	5.75e-24	96.7	COG1468@1|root,arCOG00790@2157|Archaea,41T4T@651137|Thaumarchaeota	651137|Thaumarchaeota	V	CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
k59_199084_1	7159.AAEL017453-PA	1.06e-26	113.0	COG1960@1|root,KOG0137@2759|Eukaryota,38EKS@33154|Opisthokonta,3B9YX@33208|Metazoa,3CUKV@33213|Bilateria,41V2D@6656|Arthropoda,3SHS4@50557|Insecta,455TJ@7147|Diptera,45DDG@7148|Nematocera	33208|Metazoa	I	Acyl-CoA dehydrogenase, C-terminal domain	ACADVL	GO:0000038,GO:0000062,GO:0000166,GO:0001659,GO:0003674,GO:0003824,GO:0003995,GO:0004466,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005829,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010033,GO:0010565,GO:0015980,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0017099,GO:0019216,GO:0019217,GO:0019218,GO:0019222,GO:0019395,GO:0019752,GO:0019866,GO:0023052,GO:0030154,GO:0030258,GO:0030554,GO:0030855,GO:0030968,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033554,GO:0034440,GO:0034620,GO:0034976,GO:0035966,GO:0035967,GO:0036094,GO:0036498,GO:0042221,GO:0042304,GO:0042592,GO:0042645,GO:0042760,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0046395,GO:0046890,GO:0048037,GO:0048519,GO:0048523,GO:0048856,GO:0048869,GO:0048871,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051055,GO:0051716,GO:0055114,GO:0060429,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:0072329,GO:0080090,GO:0090181,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.9	ko:K09479	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01279	RC00052	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_49845_1	640511.BC1002_2315	9.78e-20	92.4	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2VH1R@28216|Betaproteobacteria,1K2BQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	menC	-	4.2.1.113,5.5.1.1	ko:K01856,ko:K02549	ko00130,ko00361,ko00362,ko00364,ko00623,ko01100,ko01110,ko01120,ko01220,map00130,map00361,map00362,map00364,map00623,map01100,map01110,map01120,map01220	M00116,M00568	R04031,R05300,R05390,R06989,R08116,R09229	RC00903,RC01038,RC01053,RC01108,RC01321,RC01356	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k59_278837_1	436308.Nmar_1444	4.34e-142	418.0	arCOG06613@1|root,arCOG06613@2157|Archaea,41T0Z@651137|Thaumarchaeota	651137|Thaumarchaeota	V	AIPR protein	-	-	-	-	-	-	-	-	-	-	-	-	AIPR
k59_218821_1	1509405.GV67_12565	3.19e-54	182.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,4B8SA@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	L-lactate dehydrogenase	lldD2	-	1.1.2.3,1.1.99.31	ko:K00101,ko:K15054	ko00620,ko00627,ko01100,ko01120,map00620,map00627,map01100,map01120	-	R00196,R04160,R07664	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
k59_298713_1	570417.WP0605	1.01e-116	347.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,47ESY@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
k59_118454_1	522306.CAP2UW1_2870	2.27e-104	313.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,1KPSC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_29050_1	330214.NIDE0801	1.67e-57	185.0	COG0652@1|root,COG0652@2|Bacteria,3J18H@40117|Nitrospirae	40117|Nitrospirae	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
k59_59674_1	7029.ACYPI065381-PA	7.45e-20	94.0	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI065381-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_76953_1	436308.Nmar_0059	1.14e-115	337.0	COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	-	TP_methylase
k59_59683_1	1229909.NSED_06400	7.22e-52	182.0	COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
k59_317687_1	1236908.wNo_01300	8.11e-63	194.0	COG1595@1|root,COG1595@2|Bacteria,1RI42@1224|Proteobacteria,2UVC1@28211|Alphaproteobacteria,47GE4@766|Rickettsiales	766|Rickettsiales	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
k59_218851_1	436308.Nmar_0479	3.37e-81	254.0	COG0226@1|root,arCOG00213@2157|Archaea,41SXU@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM phosphate ABC transporter	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_148689_1	85643.Tmz1t_2190	4.48e-73	240.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,2KUWJ@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
k59_8318_1	589873.EP13_18395	3.2e-75	235.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RQRU@1236|Gammaproteobacteria,467JD@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_287409_2	864073.HFRIS_021116	8.5e-09	55.8	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,476TX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	CoA-transferase family III	frc_13	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
k59_199163_1	3712.Bo3g019830.1	8.87e-61	214.0	COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta	35493|Streptophyta	O	Mitochondrial protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve
k59_19094_1	570417.WP0355	1.57e-138	415.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,47EVZ@766|Rickettsiales	766|Rickettsiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_208397_1	1449353.JQMQ01000004_gene5932	2.43e-59	194.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,2NHIR@228398|Streptacidiphilus	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k59_208397_2	264198.Reut_B5509	6.91e-16	74.3	COG0251@1|root,COG0251@2|Bacteria,1REJQ@1224|Proteobacteria,2VYGJ@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_298754_1	436308.Nmar_1358	2.26e-51	178.0	COG0491@1|root,arCOG00507@2157|Archaea	2157|Archaea	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_218870_1	570417.WP1051	2.05e-83	273.0	COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gram_pos_anchor,LRR_5,YSIRK_signal,YadA_anchor,YadA_head,YadA_stalk
k59_258536_1	7159.AAEL014270-PA	6.94e-30	125.0	KOG2510@1|root,KOG2510@2759|Eukaryota,3AF29@33154|Opisthokonta,3BX0U@33208|Metazoa,3DER0@33213|Bilateria,4225P@6656|Arthropoda,3SK8J@50557|Insecta,4524T@7147|Diptera,45D85@7148|Nematocera	33208|Metazoa	B	ionotropic glutamate receptor activity	-	GO:0003008,GO:0003674,GO:0005215,GO:0005216,GO:0005575,GO:0006810,GO:0006811,GO:0007600,GO:0007606,GO:0008150,GO:0009593,GO:0015075,GO:0015267,GO:0015276,GO:0015318,GO:0016020,GO:0016021,GO:0022803,GO:0022834,GO:0022836,GO:0022838,GO:0022839,GO:0022857,GO:0031224,GO:0032501,GO:0034220,GO:0042221,GO:0044425,GO:0050877,GO:0050896,GO:0050906,GO:0050907,GO:0051179,GO:0051234,GO:0051606,GO:0055085	-	-	-	-	-	-	-	-	-	-	Lig_chan,Lig_chan-Glu_bd,SBP_bac_3
k59_246818_1	1131266.ARWQ01000028_gene1021	4.71e-60	209.0	COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the peptidase S8 family	-	-	-	ko:K14647	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PA,Peptidase_S8
k59_118518_1	7425.NV18694-PA	1.75e-45	159.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve
k59_30984_1	7029.ACYPI007813-PA	3.56e-39	153.0	2CMP4@1|root,2QR56@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_290301_1	7668.SPU_021081-tr	3.67e-12	73.9	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_210452_1	7719.XP_009858677.1	2.19e-58	210.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A17,rve
k59_160788_1	1049564.TevJSym_bj00030	2.22e-40	150.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1J4TI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	ABC_membrane,ABC_tran
k59_130844_1	1236908.wNo_10460	3.82e-126	383.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,47EYC@766|Rickettsiales	766|Rickettsiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_250326_1	1288494.EBAPG3_9710	7.49e-55	177.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,371RB@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_170691_1	7029.ACYPI003517-PA	1.46e-54	194.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T00U@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_290309_1	570417.WP0538	2.93e-54	170.0	2DCIV@1|root,2ZEB9@2|Bacteria,1P5KF@1224|Proteobacteria,2UXQ9@28211|Alphaproteobacteria,47GMZ@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_200572_1	7425.NV20553-PA	8.64e-31	134.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DIPZ@33213|Bilateria,427A1@6656|Arthropoda,3SR7X@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_60894_1	1468411.X2KPC6_9CAUD	2.39e-18	82.8	4QH94@10239|Viruses,4QWKQ@35237|dsDNA viruses  no RNA stage,4QTV5@28883|Caudovirales,4QN48@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_140673_1	570417.WP1257	1.32e-209	589.0	COG2948@1|root,COG2948@2|Bacteria,1MU7U@1224|Proteobacteria,2VEQH@28211|Alphaproteobacteria,47GRZ@766|Rickettsiales	766|Rickettsiales	U	Bacterial conjugation TrbI-like protein	-	-	-	ko:K03195	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbI
k59_180580_1	10224.XP_006822638.1	4.17e-36	132.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AS6W@33154|Opisthokonta	33154|Opisthokonta	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_40983_1	7029.ACYPI004757-PA	2.73e-59	214.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3ECWM@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_257718_1	1236908.wNo_02150	7.24e-25	102.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,47F25@766|Rickettsiales	766|Rickettsiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_257718_2	1236908.wNo_02110	1.92e-07	51.2	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,2UA2F@28211|Alphaproteobacteria,47F95@766|Rickettsiales	766|Rickettsiales	O	ankyrin repeat	-	-	-	ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
k59_117578_1	436308.Nmar_0104	2.7e-37	128.0	arCOG10515@1|root,arCOG10515@2157|Archaea,41TAP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_188664_1	7159.AAEL017306-PA	1.23e-32	126.0	2F7UK@1|root,2T8Y7@2759|Eukaryota,393KK@33154|Opisthokonta,3C8V8@33208|Metazoa,3DPX2@33213|Bilateria,4263J@6656|Arthropoda,3ST3R@50557|Insecta,457IG@7147|Diptera	7159.AAEL017306-PA|-	S	PHD-finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_268528_1	1229909.NSED_01190	2.19e-114	343.0	COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	fumarate reductase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_268528_2	436308.Nmar_0259	7.89e-80	239.0	COG2009@1|root,arCOG02244@2157|Archaea,41SKZ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_268528_3	1229909.NSED_01200	2.79e-15	70.1	COG2142@1|root,arCOG04162@2157|Archaea,41SRA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_99625_1	1380394.JADL01000008_gene3496	4.3e-18	85.1	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria,2JS0F@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
k59_235888_1	400682.PAC_15723685	7.57e-72	254.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_268531_1	887898.HMPREF0551_1867	9.91e-91	287.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1K1T3@119060|Burkholderiaceae	28216|Betaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_305859_2	436308.Nmar_1113	9.12e-96	287.0	COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
k59_198246_1	999541.bgla_1g33230	1.81e-73	233.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1K22I@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_227998_2	225849.swp_2705	4.3e-47	161.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,2Q9N9@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
k59_38966_1	882378.RBRH_01412	1.13e-07	52.4	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,1K30Z@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_38966_2	1227352.C173_23442	4.86e-33	125.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,4HH1E@91061|Bacilli,26UCZ@186822|Paenibacillaceae	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU38290	TMP-TENI
k59_38966_3	1163617.SCD_n02927	1.1e-149	427.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
k59_139285_1	330214.NIDE1411	5.74e-24	99.8	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
k59_7618_1	1229909.NSED_03765	1.62e-76	243.0	arCOG08764@1|root,arCOG08798@2157|Archaea,41SZ3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_7620_1	323848.Nmul_A2454	1.76e-49	166.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,372F6@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin_4
k59_316826_1	1236908.wNo_01370	8.6e-28	109.0	2F5JX@1|root,33Y54@2|Bacteria,1NW6N@1224|Proteobacteria,2USG7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_316826_2	1236908.wNo_01360	5.7e-90	272.0	2FITA@1|root,34AIU@2|Bacteria,1P10H@1224|Proteobacteria,2UU7S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18156_2	570417.WP1277	2.55e-152	429.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,47FBZ@766|Rickettsiales	766|Rickettsiales	S	Phosphoribosyl transferase domain	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
k59_18156_3	570417.WP1276	0.0	890.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,47EXC@766|Rickettsiales	766|Rickettsiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_305874_1	1131266.ARWQ01000002_gene636	7.34e-89	273.0	COG0001@1|root,arCOG00918@2157|Archaea,41S5Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_106856_1	163164.WD_0301	4.36e-113	338.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,47EY0@766|Rickettsiales	766|Rickettsiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_316839_1	7070.TC001491-PA	1.85e-14	78.2	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_18169_1	570417.WP1075	5.51e-80	244.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,47F6G@766|Rickettsiales	766|Rickettsiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_218019_1	1459636.NTE_03208	9.35e-151	445.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_7648_1	570417.WP0880	7.11e-128	366.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,47GI5@766|Rickettsiales	766|Rickettsiales	F	CobB/CobQ-like glutamine amidotransferase domain	-	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
k59_28230_1	7260.FBpp0245231	4.04e-49	177.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_169155_1	7029.ACYPI37654-PA	8.77e-10	60.1	KOG1075@1|root,KOG1075@2759|Eukaryota,3AUI8@33154|Opisthokonta,3CAU3@33208|Metazoa,3DS1R@33213|Bilateria,423HZ@6656|Arthropoda	2759|Eukaryota	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_89272_1	159087.Daro_4041	4.75e-13	68.2	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
k59_89272_2	221360.RS9917_00442	1.44e-22	88.2	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
k59_69209_1	1040983.AXAE01000018_gene5959	1.1e-52	177.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_99710_1	644282.Deba_3009	1.73e-67	220.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,42NCG@68525|delta/epsilon subdivisions,2WK7N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k59_169160_1	1236908.wNo_09220	4.09e-96	286.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,47GDV@766|Rickettsiales	766|Rickettsiales	F	Acetylglutamate kinase	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_316868_2	1236908.wNo_07120	1.34e-166	467.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2TTQS@28211|Alphaproteobacteria,47FAS@766|Rickettsiales	766|Rickettsiales	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_218043_1	879212.DespoDRAFT_00367	1.27e-46	158.0	COG2165@1|root,COG2165@2|Bacteria,1QYWM@1224|Proteobacteria,43DBQ@68525|delta/epsilon subdivisions,2WVZ5@28221|Deltaproteobacteria,2MNW2@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_198322_1	7029.ACYPI004927-PA	1.32e-47	174.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria,4224Q@6656|Arthropoda,3SQKC@50557|Insecta,3EE83@33342|Paraneoptera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_99727_1	1229909.NSED_00025	9.9e-78	243.0	COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
k59_235952_1	395493.BegalDRAFT_3269	1.01e-28	115.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,46035@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
k59_287913_2	990285.RGCCGE502_01431	3.94e-21	95.1	COG1566@1|root,COG1566@2|Bacteria,1QZ8G@1224|Proteobacteria,2TY5S@28211|Alphaproteobacteria,4B895@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_259134_1	570417.WP0829	4.72e-50	167.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,47F98@766|Rickettsiales	766|Rickettsiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
k59_149237_1	436308.Nmar_1605	2.86e-17	82.0	COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
k59_149237_2	1229909.NSED_08695	1.21e-88	264.0	COG1303@1|root,arCOG01857@2157|Archaea,41SIR@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
k59_149237_3	1131266.ARWQ01000009_gene937	2.47e-16	74.3	COG1675@1|root,arCOG04270@2157|Archaea,41SJ8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
k59_247360_1	570417.WP0511	1.8e-97	296.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,47F3M@766|Rickettsiales	766|Rickettsiales	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_247360_2	1236908.wNo_01770	3.54e-105	305.0	COG1502@1|root,COG1502@2|Bacteria,1N31R@1224|Proteobacteria,2UBQT@28211|Alphaproteobacteria,47FHI@766|Rickettsiales	766|Rickettsiales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	3.1.4.4	ko:K17717	ko00564,ko00565,ko01100,ko01110,map00564,map00565,map01100,map01110	-	R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_209040_1	1132855.KB913035_gene2273	6.74e-54	174.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,2KMSR@206350|Nitrosomonadales	206350|Nitrosomonadales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
k59_318417_1	557598.LHK_00251	1.38e-93	283.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,2KQ8R@206351|Neisseriales	206351|Neisseriales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_8893_1	1131266.ARWQ01000002_gene555	1.34e-07	52.4	COG0502@1|root,arCOG00658@2157|Archaea,41S9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_8893_2	1229909.NSED_04530	2.11e-52	177.0	COG0156@1|root,arCOG00113@2157|Archaea,41SAP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	8-amino-7-oxononanoate synthase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_158641_1	1229909.NSED_01720	2.91e-64	202.0	COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_158641_2	1229909.NSED_01715	4.59e-20	82.4	arCOG10523@1|root,arCOG10523@2157|Archaea,41SSZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_318431_1	1236908.wNo_02700	2.8e-125	358.0	COG2823@1|root,COG2823@2|Bacteria,1NJK0@1224|Proteobacteria,2U9XB@28211|Alphaproteobacteria,47FG5@766|Rickettsiales	766|Rickettsiales	S	periplasmic or secreted lipoprotein	osmY	-	-	-	-	-	-	-	-	-	-	-	BON
k59_108211_1	7425.NV24961-PA	6.89e-52	183.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_259237_1	7370.XP_005191617.1	1.27e-63	207.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VQT@33154|Opisthokonta,3C60G@33208|Metazoa,3DM2C@33213|Bilateria,4278Y@6656|Arthropoda,3SSMC@50557|Insecta,454TX@7147|Diptera	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_19902_1	1394178.AWOO02000022_gene7157	3.43e-48	166.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,4EHI5@85012|Streptosporangiales	201174|Actinobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_288025_1	570417.WP1019	2.64e-15	70.9	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2UCHU@28211|Alphaproteobacteria,47FIU@766|Rickettsiales	766|Rickettsiales	Q	COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_288025_2	163164.WD_0253	7.29e-23	96.3	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,47G04@766|Rickettsiales	766|Rickettsiales	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_247451_2	436308.Nmar_0855	6.11e-38	128.0	arCOG08032@1|root,arCOG08032@2157|Archaea,41T69@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_247451_3	1131266.ARWQ01000002_gene527	7.31e-27	99.8	COG1522@1|root,arCOG01117@2157|Archaea,41T6U@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_237064_1	330214.NIDE0471	4.03e-40	141.0	COG0037@1|root,COG0037@2|Bacteria	2|Bacteria	D	tRNA processing	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.1.15,6.3.4.19	ko:K04075,ko:K14058,ko:K21947	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
k59_237064_2	289376.THEYE_A1774	8.24e-14	69.7	COG0704@1|root,COG0704@2|Bacteria,3J0M6@40117|Nitrospirae	40117|Nitrospirae	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
k59_209121_1	1229781.C272_07357	4.48e-19	89.0	COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,4FB7F@85019|Brevibacteriaceae	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
k59_77551_1	436308.Nmar_1627	1.45e-197	572.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_306896_1	436308.Nmar_0670	5.19e-89	270.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine synthase	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_29845_2	344747.PM8797T_31333	2.31e-14	69.7	2E86B@1|root,332JP@2|Bacteria,2J106@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_29847_1	469383.Cwoe_0829	2.3e-49	181.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CRAY@84995|Rubrobacteria	201174|Actinobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
k59_29854_1	1236908.wNo_00820	1.66e-170	479.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2TS3X@28211|Alphaproteobacteria,47ETF@766|Rickettsiales	766|Rickettsiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_218162_1	570417.WP1101	2.54e-87	278.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,47F10@766|Rickettsiales	766|Rickettsiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_218162_2	570417.WP1102	5.27e-23	96.7	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,47F34@766|Rickettsiales	766|Rickettsiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_268789_1	765911.Thivi_2342	5.21e-56	179.0	299T8@1|root,2ZWVF@2|Bacteria,1N5QA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_268789_2	522306.CAP2UW1_2978	3.9e-12	65.1	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_188877_1	1131553.JIBI01000002_gene1804	1.39e-96	298.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,372MX@32003|Nitrosomonadales	28216|Betaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
k59_198458_1	570417.WP1250	2.07e-113	337.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,47F0X@766|Rickettsiales	766|Rickettsiales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_49274_1	1236908.wNo_01570	8e-107	320.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria,47F5P@766|Rickettsiales	766|Rickettsiales	NU	Bacterial type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N_2
k59_7750_1	1280692.AUJL01000038_gene334	4.68e-23	95.5	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,36DF9@31979|Clostridiaceae	186801|Clostridia	E	ABC transporter	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_139560_1	7029.ACYPI34001-PA	1.98e-05	52.4	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria,4224Q@6656|Arthropoda,3SQKC@50557|Insecta,3EE83@33342|Paraneoptera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_198487_1	1131266.ARWQ01000001_gene1357	1.02e-133	383.0	COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_228216_1	436308.Nmar_0207	7.29e-99	301.0	COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Vinylacetyl-CoA Delta-isomerase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_218197_1	339670.Bamb_3213	1.36e-71	233.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,1JZXE@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_228226_1	570417.WP0760	1.36e-125	367.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,47EX5@766|Rickettsiales	766|Rickettsiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_39201_1	938288.HG326226_gene541	4.56e-08	57.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,26892@186813|unclassified Clostridiales	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_39201_2	1131266.ARWQ01000002_gene610	4.35e-18	77.8	arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_278255_1	671143.DAMO_0479	3.22e-37	140.0	COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
k59_246251_1	436308.Nmar_0479	2.79e-83	258.0	COG0226@1|root,arCOG00213@2157|Archaea,41SXU@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM phosphate ABC transporter	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_157386_1	1229909.NSED_07545	1.09e-67	216.0	COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
k59_286895_1	1236908.wNo_09290	4.37e-81	245.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,2VF0M@28211|Alphaproteobacteria,47GQ8@766|Rickettsiales	766|Rickettsiales	P	Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k59_286895_2	1236908.wNo_09300	8.38e-71	226.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,47EUS@766|Rickettsiales	766|Rickettsiales	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
k59_89480_1	1236908.wNo_00040	1.61e-133	392.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,47EXM@766|Rickettsiales	766|Rickettsiales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_7800_1	1347086.CCBA010000025_gene3090	9.99e-16	79.0	COG0441@1|root,COG0441@2|Bacteria,1UHT4@1239|Firmicutes,4IS8T@91061|Bacilli,1ZS31@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_7800_2	436308.Nmar_0657	2.44e-11	63.5	COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_198539_1	1236908.wNo_08540	1.02e-29	111.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,47EY4@766|Rickettsiales	766|Rickettsiales	IQ	dehydrogenases with different specificities (related to short-chain alcohol)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_188935_1	1236908.wNo_10350	6.32e-149	419.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,47FB2@766|Rickettsiales	766|Rickettsiales	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_139601_1	7425.NV18588-PA	5.55e-25	111.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_188937_1	570417.WP1259	5.07e-112	339.0	COG3505@1|root,COG3505@2|Bacteria,1MV1G@1224|Proteobacteria,2TR6N@28211|Alphaproteobacteria,47EW8@766|Rickettsiales	766|Rickettsiales	U	Type IV secretion system protein VirD4	virD4	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
k59_246258_1	1297865.APJD01000003_gene6130	4.84e-16	90.1	COG1572@1|root,COG2755@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG1572@2|Bacteria,COG2755@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3JWUW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HemolysinCabind
k59_236086_1	1459636.NTE_03208	5.94e-115	349.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_178333_1	27923.ML106631a-PA	9.68e-06	53.1	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	2.6.1.1	ko:K06115,ko:K14454	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00710,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00710,map00950,map00960,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00170,M00171	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007,ko04131,ko04147,ko04812	-	-	-	RVT_1
k59_307562_1	296591.Bpro_2800	9.82e-102	311.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	oxc	-	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100	-	R01908	RC00620	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_248142_1	7029.ACYPI52857-PA	8.04e-70	248.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_109048_1	7029.ACYPI061017-PA	3.58e-41	160.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria,42261@6656|Arthropoda	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10577	ko03013,ko04064,ko04120,ko05206,map03013,map04064,map04120,map05206	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko04121	-	-	-	RVT_1
k59_307579_2	570417.WP1136	7.41e-155	442.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,47EW1@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
k59_109131_1	56110.Oscil6304_3459	9.13e-12	66.6	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HAPE@1150|Oscillatoriales	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	hetI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_109131_2	264730.PSPPH_2416	1.16e-10	62.4	COG0031@1|root,COG2423@1|root,COG0031@2|Bacteria,COG2423@2|Bacteria,1NC53@1224|Proteobacteria,1RYJB@1236|Gammaproteobacteria,1Z57T@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	2.5.1.140	ko:K21949	-	-	R11705	-	ko00000,ko01000	-	-	-	OCD_Mu_crystall,PALP
k59_159566_1	321332.CYB_1098	2.89e-71	224.0	COG1335@1|root,COG1335@2|Bacteria,1G10P@1117|Cyanobacteria,1GZXY@1129|Synechococcus	1117|Cyanobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_78634_1	614083.AWQR01000031_gene2542	4.48e-69	224.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AAHM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_78643_1	570417.WP0530	2.5e-166	475.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,47FWN@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_237983_1	7425.NV18588-PA	1.05e-26	116.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_237987_1	7029.ACYPI41534-PA	4.11e-52	187.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_109262_1	7159.AAEL001225-PA	1.17e-28	122.0	COG2723@1|root,KOG0626@2759|Eukaryota,38CCU@33154|Opisthokonta,3BCXZ@33208|Metazoa,3CT1M@33213|Bilateria,41XRS@6656|Arthropoda,3SQRU@50557|Insecta,44X5T@7147|Diptera,45F1J@7148|Nematocera	33208|Metazoa	G	Belongs to the glycosyl hydrolase 1 family	LCT	GO:0000016,GO:0001666,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0005903,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006677,GO:0006687,GO:0006807,GO:0006950,GO:0007584,GO:0007586,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009605,GO:0009628,GO:0009636,GO:0009719,GO:0009725,GO:0009743,GO:0009744,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010040,GO:0010045,GO:0010288,GO:0012505,GO:0015925,GO:0015926,GO:0016020,GO:0016021,GO:0016042,GO:0016324,GO:0016740,GO:0016787,GO:0016798,GO:0017042,GO:0019377,GO:0030149,GO:0031224,GO:0031226,GO:0031667,GO:0032501,GO:0034285,GO:0034641,GO:0036293,GO:0042221,GO:0042493,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043627,GO:0044237,GO:0044238,GO:0044242,GO:0044245,GO:0044248,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045177,GO:0045471,GO:0046466,GO:0046477,GO:0046479,GO:0046514,GO:0046677,GO:0050896,GO:0070482,GO:0071704,GO:0071944,GO:0097305,GO:0098590,GO:0098862,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901700,GO:1903509	3.2.1.108,3.2.1.21,3.2.1.62	ko:K01229,ko:K05350	ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,ko04973,map00052,map00460,map00500,map00940,map01100,map01110,map04973	-	R00026,R01678,R02558,R02887,R02985,R03527,R04949,R04998,R06114,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000,ko03110	-	-	-	Glyco_hydro_1
k59_109277_1	570417.WP0388	3.4e-30	117.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_109277_2	570417.WP0388	6.53e-15	73.6	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_307721_1	7070.TC011220-PA	4.35e-130	422.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_307721_4	7070.TC011220-PA	1.74e-91	318.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_238018_1	7029.ACYPI062999-PA	1.81e-82	275.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_289063_2	436308.Nmar_0008	1.55e-85	266.0	COG1252@1|root,arCOG01067@2157|Archaea	2157|Archaea	C	COG1252 NADH dehydrogenase, FAD-containing subunit	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_238024_1	570417.WP0820	1.28e-52	171.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,47F5J@766|Rickettsiales	766|Rickettsiales	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
k59_238024_2	1236908.wNo_04770	6.14e-43	144.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,47FDI@766|Rickettsiales	766|Rickettsiales	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
k59_109358_5	1415148.V5Q7E3_9CAUD	3.44e-21	92.4	4QGPT@10239|Viruses,4QQI9@28883|Caudovirales,4QMUP@10699|Siphoviridae	10699|Siphoviridae	S	DNA catabolic process, endonucleolytic	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_238083_1	570417.WP0526	3.34e-201	570.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,47FMX@766|Rickettsiales	766|Rickettsiales	O	COG0760 Parvulin-like peptidyl-prolyl isomerase	surA	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
k59_109400_1	305700.B447_15431	1e-25	100.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KWHT@206389|Rhodocyclales	206389|Rhodocyclales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_248499_1	1459636.NTE_00041	1.5e-58	195.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	2157|Archaea	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
k59_78883_1	1229909.NSED_01640	3.88e-154	444.0	COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_109448_1	436308.Nmar_0658	2.09e-104	314.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_141150_1	1236908.wNo_02270	4.89e-100	296.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,47F2X@766|Rickettsiales	766|Rickettsiales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
k59_61356_1	261292.Nit79A3_0003	9.33e-156	462.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3725J@32003|Nitrosomonadales	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_11422_1	43151.ADAC007967-PA	1.47e-76	261.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,429UH@6656|Arthropoda,3T0UB@50557|Insecta,458R2@7147|Diptera	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_61364_2	1131266.ARWQ01000012_gene1608	9.28e-71	227.0	COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
k59_141157_2	985053.VMUT_0367	2.55e-15	79.3	COG1573@1|root,arCOG00905@2157|Archaea,2XQ7T@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_210922_1	330214.NIDE1082	2.07e-31	123.0	COG0845@1|root,COG0845@2|Bacteria,3J0HQ@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
k59_210922_2	330214.NIDE1083	8.43e-72	222.0	COG1136@1|root,COG1136@2|Bacteria,3J10N@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_141165_1	7029.ACYPI062999-PA	5.67e-40	149.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_171205_2	1229909.NSED_01945	6.18e-98	298.0	COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota	651137|Thaumarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
k59_150974_1	570417.WP1245	2.08e-103	303.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,47F0G@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_150974_2	570417.WP1244	3.61e-167	469.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,47EWI@766|Rickettsiales	766|Rickettsiales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
k59_270903_1	1209072.ALBT01000061_gene989	7.48e-05	45.8	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1FFVJ@10|Cellvibrio	1236|Gammaproteobacteria	V	hmm pf00005	draA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_270903_2	713586.KB900536_gene378	1.64e-25	100.0	COG0599@1|root,COG0599@2|Bacteria,1PG95@1224|Proteobacteria,1SY84@1236|Gammaproteobacteria,1X218@135613|Chromatiales	135613|Chromatiales	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_131428_1	570417.WP0676	1.07e-102	303.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,47G4A@766|Rickettsiales	766|Rickettsiales	F	nucleobase biosynthetic process	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_191131_1	7070.TC008494-PA	2.91e-67	237.0	COG2801@1|root,KOG0017@2759|Eukaryota,3AFV1@33154|Opisthokonta,3BYSE@33208|Metazoa,3DEVX@33213|Bilateria,4228H@6656|Arthropoda,3SQGD@50557|Insecta	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A2B,RVT_1,Retrotrans_gag,rve,zf-CCHC
k59_290837_1	570417.WP0950	2.14e-28	111.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,47F4T@766|Rickettsiales	766|Rickettsiales	S	TldD protein	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_41545_1	887898.HMPREF0551_0997	4.63e-15	74.7	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1K242@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_41545_2	887898.HMPREF0551_0998	5.11e-66	210.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,1K01D@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	frdB	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_121296_1	7165.AGAP013330-PA	2.37e-15	79.0	2CEB9@1|root,2T8EY@2759|Eukaryota,392Z7@33154|Opisthokonta,3C89K@33208|Metazoa,3DPA8@33213|Bilateria,425IH@6656|Arthropoda,3SV3U@50557|Insecta,456UI@7147|Diptera,45M4H@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_61391_1	570417.WP0109	2.24e-108	315.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,47FZ2@766|Rickettsiales	766|Rickettsiales	P	Belongs to the ABC transporter superfamily	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_61391_2	1236908.wNo_00210	6.45e-38	133.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,47F9P@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_280693_1	161934.XP_010676254.1	7.7e-47	173.0	COG2801@1|root,KOG0017@2759|Eukaryota,3894V@33090|Viridiplantae,3GY0Z@35493|Streptophyta	35493|Streptophyta	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
k59_112545_1	1131266.ARWQ01000009_gene952	7.38e-86	261.0	COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_172556_1	1046714.AMRX01000006_gene3179	2.48e-21	100.0	291GM@1|root,2ZP3A@2|Bacteria,1RD1E@1224|Proteobacteria,1S4X6@1236|Gammaproteobacteria,46AXH@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_52710_1	1380394.JADL01000002_gene1394	8.32e-98	297.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,2JT4J@204441|Rhodospirillales	204441|Rhodospirillales	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
k59_202426_1	1001585.MDS_1424	2.19e-06	57.4	COG2304@1|root,COG2931@1|root,COG3898@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3898@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1YE9I@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,HemolysinCabind,PA14
k59_33028_1	1288494.EBAPG3_9730	1.96e-110	319.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,3722Z@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_33028_2	1288494.EBAPG3_9740	1.15e-42	142.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,2VUPV@28216|Betaproteobacteria,373IJ@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
k59_62682_1	1229909.NSED_07425	5.42e-42	142.0	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_172574_1	580332.Slit_1529	1.64e-12	66.6	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,44V99@713636|Nitrosomonadales	28216|Betaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645,ko:K13935,ko:K15355	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
k59_172574_2	1132855.KB913035_gene1451	2.12e-50	169.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,2KM2A@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_202429_1	1229909.NSED_07055	3.81e-110	324.0	COG0111@1|root,arCOG01754@2157|Archaea,41S8U@651137|Thaumarchaeota	651137|Thaumarchaeota	H	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_152188_1	264198.Reut_A2745	7.62e-93	298.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1K19S@119060|Burkholderiaceae	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_292174_1	999541.bgla_1g05340	1.48e-105	315.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1K06J@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_132910_1	536019.Mesop_0921	2.15e-22	96.7	COG2020@1|root,COG2020@2|Bacteria,1N2GB@1224|Proteobacteria,2UCT1@28211|Alphaproteobacteria,43P8C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_83029_1	7425.NV24979-PA	4.06e-36	140.0	COG2801@1|root,KOG1075@1|root,KOG0017@2759|Eukaryota,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_262288_1	1236908.wNo_09450	1.71e-116	345.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,47F12@766|Rickettsiales	766|Rickettsiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_172576_1	70601.3256838	2.49e-75	236.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,243AA@183968|Thermococci	183968|Thermococci	J	required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
k59_12751_1	323848.Nmul_A0001	1.64e-93	286.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,372M3@32003|Nitrosomonadales	28216|Betaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_162876_1	331869.BAL199_01614	2.4e-61	201.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,4BSYN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_122626_1	1185876.BN8_00350	9.58e-11	64.7	COG4301@1|root,COG4301@2|Bacteria,4NEFC@976|Bacteroidetes,47KDA@768503|Cytophagia	976|Bacteroidetes	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
k59_122626_2	436308.Nmar_0657	1.19e-118	350.0	COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
k59_102156_1	8479.XP_008175316.1	1.06e-05	52.8	COG2373@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1366@2759|Eukaryota,38DGN@33154|Opisthokonta,3BCF2@33208|Metazoa,3CTZZ@33213|Bilateria,480CR@7711|Chordata	33208|Metazoa	O	serine-type endopeptidase inhibitor activity	A2ML1	-	-	ko:K03910	ko04610,map04610	-	-	-	ko00000,ko00001,ko04131,ko04147	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
k59_202444_1	570417.WP0216	7.06e-160	457.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,47EZ7@766|Rickettsiales	766|Rickettsiales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k59_93056_1	7159.AAEL011646-PA	1.09e-55	187.0	2E0WI@1|root,2S89W@2759|Eukaryota,397E2@33154|Opisthokonta,3CBQ5@33208|Metazoa,3DSZQ@33213|Bilateria,424KF@6656|Arthropoda,3STV6@50557|Insecta,45B4K@7147|Diptera,45KZ8@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_262302_2	314230.DSM3645_23366	1.53e-15	74.3	COG0307@1|root,COG0307@2|Bacteria,2IZ6H@203682|Planctomycetes	203682|Planctomycetes	H	riboflavin synthase alpha chain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
k59_12769_1	436308.Nmar_1597	7.71e-103	310.0	COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_43092_1	7070.TC011220-PA	8.49e-74	252.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_241565_2	570417.WP0155	2.88e-83	251.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,47FAE@766|Rickettsiales	766|Rickettsiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
k59_122640_1	589873.EP13_14610	1.59e-26	103.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,464UB@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0668 Small-conductance mechanosensitive channel	mscS	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k59_122640_2	1137268.AZXF01000005_gene3067	3.05e-17	82.8	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4EG1Y@85012|Streptosporangiales	201174|Actinobacteria	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k59_132955_1	330214.NIDE3256	1.06e-116	344.0	COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ddhB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.5.1	ko:K00371,ko:K16965,ko:K17048,ko:K17051	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Fer4_11
k59_52748_2	400682.PAC_15705808	7.04e-150	457.0	2CNQC@1|root,2QXFF@2759|Eukaryota,39Y03@33154|Opisthokonta,3BMKX@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_43106_1	7425.NV10089-PA	1.01e-37	145.0	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_272330_1	13249.RPRC004562-PA	6.57e-36	133.0	COG1236@1|root,KOG1137@2759|Eukaryota,391IR@33154|Opisthokonta,3BZTJ@33208|Metazoa,3DN45@33213|Bilateria,42BX0@6656|Arthropoda,3STTZ@50557|Insecta,3EDBM@33342|Paraneoptera	33208|Metazoa	A	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_272330_2	570417.WP0222	2.52e-93	281.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,47EVB@766|Rickettsiales	766|Rickettsiales	A	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_311707_1	404589.Anae109_1864	1.46e-149	429.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,2YV6M@29|Myxococcales	28221|Deltaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284,ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4	-	-	CorA
k59_172615_1	1229909.NSED_01675	7.32e-173	520.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_72044_2	7159.AAEL017299-PA	1.62e-85	284.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_142570_1	330214.NIDE0426	4.64e-134	396.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae	40117|Nitrospirae	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_202493_1	7425.NV21123-PA	2.83e-29	122.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria,42261@6656|Arthropoda,3SQT9@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_62747_1	6087.XP_004208172.1	4.33e-34	136.0	KOG1020@1|root,KOG1020@2759|Eukaryota	2759|Eukaryota	K	cohesin loading	-	-	-	ko:K06672	ko04111,map04111	-	-	-	ko00000,ko00001,ko03036	-	-	-	Cohesin_HEAT,Nipped-B_C
k59_301652_2	768671.ThimaDRAFT_4834	5.59e-15	70.1	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,1S9Q2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
k59_2668_1	7029.ACYPI065353-PA	3.99e-37	144.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_8784_1	1459636.NTE_03553	3.44e-92	281.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_149185_1	330214.NIDE1345	1.17e-14	71.6	COG1544@1|root,COG1544@2|Bacteria,3J0V7@40117|Nitrospirae	40117|Nitrospirae	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
k59_179480_1	1459636.NTE_01667	6.13e-25	97.8	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_179480_2	1229909.NSED_00840	1.5e-27	108.0	arCOG10597@1|root,arCOG10597@2157|Archaea	1229909.NSED_00840|-	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_149191_1	545696.HOLDEFILI_02111	1.79e-06	55.8	COG3629@1|root,COG3629@2|Bacteria,1UWHI@1239|Firmicutes,3VQAK@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
k59_19695_1	7260.FBpp0254607	1.23e-40	153.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_108080_1	314278.NB231_03600	1.96e-103	313.0	COG3746@1|root,COG3746@2|Bacteria,1RAJS@1224|Proteobacteria,1S3ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
k59_259126_1	1131266.ARWQ01000001_gene1340	5.25e-80	244.0	COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_247318_1	420324.KI912020_gene7461	8.94e-33	125.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	MA20_26940	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_271106_1	1288494.EBAPG3_9670	2.32e-131	410.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,37253@32003|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_101235_2	323848.Nmul_A0002	2.1e-42	150.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,371UF@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_131614_1	400682.PAC_15703055	2.88e-38	148.0	COG2801@1|root,KOG0017@2759|Eukaryota,3ACW4@33154|Opisthokonta,3BVPH@33208|Metazoa	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
k59_61611_1	323848.Nmul_A2630	3.73e-61	195.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,372YC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome c, class I	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_51624_1	570417.WP0207	4.67e-150	427.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,47EYW@766|Rickettsiales	766|Rickettsiales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M,Zn_ribbon_recom
k59_211130_1	69319.XP_008547699.1	4.07e-34	134.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria,4224Q@6656|Arthropoda,3SQKC@50557|Insecta,46KTK@7399|Hymenoptera	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_21692_1	1144342.PMI40_02044	9.34e-54	182.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,472E7@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_300673_1	1229909.NSED_09200	1.52e-24	96.7	COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_300673_2	436308.Nmar_1729	7.39e-42	147.0	COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
k59_31810_1	570417.WP1120	6.11e-59	197.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,47F1D@766|Rickettsiales	766|Rickettsiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_31810_2	570417.WP1119	1.16e-34	121.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,47FSV@766|Rickettsiales	766|Rickettsiales	S	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
k59_171435_1	1131266.ARWQ01000008_gene319	1.5e-60	192.0	COG0120@1|root,arCOG01122@2157|Archaea,41SJE@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Ribose 5-phosphate isomerase	-	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
k59_171435_2	1131266.ARWQ01000008_gene320	6.01e-98	298.0	COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_21693_1	944435.AXAJ01000002_gene4577	3.51e-96	283.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,1JZYT@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
k59_291029_1	1236908.wNo_04070	1.65e-131	383.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria,47F0Z@766|Rickettsiales	766|Rickettsiales	P	domain protein	corB	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_291029_2	1236908.wNo_04080	1.76e-12	65.9	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,47F7A@766|Rickettsiales	766|Rickettsiales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	argD	-	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_141378_1	7029.ACYPI38899-PA	4.99e-18	91.7	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_181344_1	243365.CV_2096	5.04e-24	105.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KQ1K@206351|Neisseriales	206351|Neisseriales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_1559_1	1121927.GOHSU_53_00160	6.27e-25	106.0	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria,4GCGN@85026|Gordoniaceae	201174|Actinobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_71144_1	7370.XP_005182599.1	2.03e-11	67.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,4556V@7147|Diptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_141380_2	1231185.BAMP01000072_gene3373	3.62e-21	91.3	COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,2TRSQ@28211|Alphaproteobacteria,43JRA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_91791_2	1229909.NSED_09235	3.15e-52	171.0	arCOG03788@1|root,arCOG03788@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
k59_41787_1	879212.DespoDRAFT_01479	1.34e-37	139.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_121484_1	570417.WP0222	1.26e-83	256.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,47EVB@766|Rickettsiales	766|Rickettsiales	A	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_81817_1	1229909.NSED_00180	2.91e-34	132.0	COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_81817_2	1131266.ARWQ01000001_gene1258	3.86e-36	131.0	COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DnaJ central domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_11671_1	436308.Nmar_0674	6.14e-10	57.4	COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota	651137|Thaumarchaeota	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_11671_2	1131266.ARWQ01000002_gene520	4.67e-41	142.0	COG0596@1|root,arCOG01648@2157|Archaea,41SFU@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_300690_1	570417.WP1239	1.24e-50	170.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	DUF1079,PhageMin_Tail
k59_171469_1	543728.Vapar_3819	2.33e-97	293.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VK3Y@28216|Betaproteobacteria,4AGID@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.4.1.24	ko:K16846	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	GD_AH_C
k59_121490_1	10224.XP_006821686.1	4.17e-33	134.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria	33208|Metazoa	J	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_31846_1	7029.ACYPI53216-PA	4.37e-33	134.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	ko:K03102	ko04320,map04320	-	-	-	ko00000,ko00001,ko03019,ko03041	-	-	-	Exo_endo_phos_2,RVT_1
k59_221113_1	1131266.ARWQ01000005_gene807	1.19e-112	328.0	COG0007@1|root,arCOG00644@2157|Archaea,41S9J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
k59_31849_1	443152.MDG893_16902	2.24e-94	298.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,465RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_171490_1	1333856.L686_00625	7.27e-13	67.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1Z006@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
k59_171490_2	313612.L8106_12555	9.42e-63	200.0	COG0457@1|root,COG0457@2|Bacteria,1G6S8@1117|Cyanobacteria,1HGG7@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
k59_1577_1	1869.MB27_07190	7.13e-10	66.2	COG3091@1|root,COG3091@2|Bacteria,2IJ4Z@201174|Actinobacteria	201174|Actinobacteria	S	SprT-like family	-	-	-	-	-	-	-	-	-	-	-	-	SprT-like
k59_11690_1	631454.N177_1007	0.000745	43.9	COG3181@1|root,COG3181@2|Bacteria,1PGFA@1224|Proteobacteria,2V8Q5@28211|Alphaproteobacteria,1JQCI@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_11690_2	1500257.JQNM01000014_gene2936	3.04e-18	85.9	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,4BCQJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_71179_1	436308.Nmar_0944	2.48e-90	279.0	COG1111@1|root,arCOG00872@2157|Archaea	2157|Archaea	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03703,ko:K10896	ko03420,ko03460,map03420,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
k59_230869_1	436308.Nmar_0323	4.27e-15	73.9	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_230869_2	1229909.NSED_01565	1.2e-32	120.0	COG0522@1|root,arCOG04239@2157|Archaea,41SN3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
k59_61660_1	7029.ACYPI52857-PA	1.57e-87	313.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_280916_1	1236908.wNo_02420	2.91e-36	135.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,47EUQ@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_280916_2	570417.WP0668	1.59e-24	102.0	COG4886@1|root,COG4886@2|Bacteria,1NJBW@1224|Proteobacteria	1224|Proteobacteria	S	Type III effector protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6
k59_230875_1	13249.RPRC005728-PA	5.08e-15	82.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3EC30@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1,zf-CCHC
k59_91868_1	1236908.wNo_07780	3.23e-142	412.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	alanine symporter	alsT	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_21761_2	7176.CPIJ007264-PA	1.22e-111	366.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda,3SP5N@50557|Insecta,455R4@7147|Diptera,45DRP@7148|Nematocera	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_271212_1	649747.HMPREF0083_01593	2.53e-05	52.4	COG3385@1|root,COG3385@2|Bacteria,1UNGW@1239|Firmicutes,4HBQN@91061|Bacilli,26ZE9@186822|Paenibacillaceae	91061|Bacilli	L	Transposase DDE domain	iS4C	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_261239_1	292415.Tbd_0071	8.46e-101	302.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KSZD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
k59_151267_1	7425.NV18821-PA	0.000243	48.9	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RRM_1,RVT_1,rve,zf-H2C2
k59_81907_1	570417.WP0654	4.94e-57	189.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,47FVU@766|Rickettsiales	766|Rickettsiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k59_21763_1	400682.PAC_15705808	8.06e-94	302.0	2CNQC@1|root,2QXFF@2759|Eukaryota,39Y03@33154|Opisthokonta,3BMKX@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_131735_1	1227500.C494_04970	3.63e-23	95.9	arCOG10716@1|root,arCOG10716@2157|Archaea,2XXD6@28890|Euryarchaeota,241G0@183963|Halobacteria	183963|Halobacteria	S	PD-(D/E)XK endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_5
k59_1620_1	640081.Dsui_1936	9.86e-78	246.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,2KV5W@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_310795_1	5059.CADAFLAP00013483	3.41e-88	282.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39SG3@33154|Opisthokonta,3P4RB@4751|Fungi	4751|Fungi	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_251151_1	1123487.KB892868_gene1207	1.5e-123	392.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,2KUPX@206389|Rhodocyclales	206389|Rhodocyclales	E	glutamate synthase	gls1	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_221182_2	570417.WP0113	6.95e-94	284.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,47F53@766|Rickettsiales	766|Rickettsiales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k59_133895_1	281687.CJA33237a	1.33e-27	122.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39B3I@33154|Opisthokonta,3CF5T@33208|Metazoa,3DWJC@33213|Bilateria,40HPD@6231|Nematoda,1M0XI@119089|Chromadorea,40RQ1@6236|Rhabditida	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_282614_3	1229909.NSED_08720	4.2e-15	69.7	arCOG10596@1|root,arCOG10596@2157|Archaea,41T8F@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_282614_4	251229.Chro_0970	1.82e-32	121.0	COG4333@1|root,COG4333@2|Bacteria,1G73U@1117|Cyanobacteria,3VK7K@52604|Pleurocapsales	1117|Cyanobacteria	S	Protein of unknown function (DUF1643)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1643
k59_102769_1	436308.Nmar_0552	1.57e-210	587.0	COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
k59_102769_2	436308.Nmar_0553	4.13e-160	451.0	COG1830@1|root,arCOG04044@2157|Archaea,41SCP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_102769_3	436308.Nmar_0554	1.08e-55	183.0	COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_133898_2	570417.WP1105	2.69e-140	403.0	COG0666@1|root,COG0666@2|Bacteria,1MVPK@1224|Proteobacteria,2UH60@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
k59_273157_1	570417.WP0903	2.67e-106	322.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,47EWQ@766|Rickettsiales	766|Rickettsiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_222946_1	27923.ML00302a-PA	2.81e-12	72.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_193392_1	330214.NIDE2638	6.91e-26	107.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,3J0ZS@40117|Nitrospirae	40117|Nitrospirae	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k59_193392_2	330214.NIDE2639	0.000124	44.3	COG1052@1|root,COG1052@2|Bacteria,3J13M@40117|Nitrospirae	40117|Nitrospirae	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_94018_1	7070.TC008496-PA	1.42e-77	261.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_163812_1	388401.RB2150_17299	4.56e-108	318.0	COG2801@1|root,COG2801@2|Bacteria,1RG0C@1224|Proteobacteria,2U7S5@28211|Alphaproteobacteria,3ZHKU@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_29,HTH_32,rve,rve_3
k59_183507_1	387093.SUN_2375	1.6e-56	199.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,42M77@68525|delta/epsilon subdivisions,2YRQV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k59_152938_1	7029.ACYPI067418-PA	1.37e-25	110.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EDAB@33342|Paraneoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_84042_1	330214.NIDE4114	6.17e-90	276.0	COG0440@1|root,COG0460@1|root,COG0440@2|Bacteria,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae	40117|Nitrospirae	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
k59_53663_1	460265.Mnod_4822	3.34e-91	275.0	COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM formyl transferase domain protein	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
k59_263225_1	292415.Tbd_2282	1.32e-104	320.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_102804_1	570417.WP0494	2.79e-194	547.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Malonyl-CoA decarboxylase	mcd	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
k59_242248_1	570417.WP0368	2.85e-116	357.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,47EYC@766|Rickettsiales	766|Rickettsiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_163851_1	1229909.NSED_02630	1.68e-37	135.0	COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_163851_2	436308.Nmar_0522	7.23e-52	169.0	COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota	651137|Thaumarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	-
k59_273221_2	234267.Acid_7639	5.53e-64	209.0	COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria	57723|Acidobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
k59_163852_1	1236908.wNo_04450	4.05e-118	346.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,47F7A@766|Rickettsiales	766|Rickettsiales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	argD	-	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_163852_2	570417.WP0782	4.7e-14	70.9	COG1061@1|root,COG1061@2|Bacteria	2|Bacteria	L	Type III restriction enzyme res subunit	-	GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF3427,DUF3854,Helicase_C,ResIII
k59_34021_1	570417.WP1081	3.21e-33	121.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2TSQD@28211|Alphaproteobacteria,47EZ5@766|Rickettsiales	766|Rickettsiales	G	fructose-bisphosphate aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_133953_1	1229909.NSED_02820	4.06e-82	243.0	arCOG08652@1|root,arCOG08652@2157|Archaea,41SMZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_133953_2	1459636.NTE_01710	1.39e-30	108.0	arCOG10521@1|root,arCOG10521@2157|Archaea,41T8A@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_34024_1	1131266.ARWQ01000008_gene308	7.55e-115	347.0	COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
k59_242262_1	32057.KB217478_gene3286	1.86e-14	75.5	COG2433@1|root,COG2433@2|Bacteria,1G2BH@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_102816_1	7425.NV18233-PA	5.57e-65	236.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXJQ@33208|Metazoa,3DGER@33213|Bilateria,422ER@6656|Arthropoda,3SR16@50557|Insecta,46M71@7399|Hymenoptera	33208|Metazoa	S	Domain of unknown function (DUF4780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780,Exo_endo_phos_2,RNase_H,RVT_1
k59_63781_1	500640.CIT292_08808	4.22e-33	119.0	2AHMX@1|root,317ZV@2|Bacteria,1PZIR@1224|Proteobacteria,1SU9H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_113463_1	7260.FBpp0239958	2.83e-05	43.9	29KBU@1|root,2RTKP@2759|Eukaryota,3AQ97@33154|Opisthokonta,3C2Q2@33208|Metazoa,3DIFI@33213|Bilateria,424FS@6656|Arthropoda,3STPR@50557|Insecta,457K7@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_72750_1	400682.PAC_15703055	5.11e-75	251.0	COG2801@1|root,KOG0017@2759|Eukaryota,3ACW4@33154|Opisthokonta,3BVPH@33208|Metazoa	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
k59_263263_1	163164.WD_1081	9.06e-161	463.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,47FNZ@766|Rickettsiales	766|Rickettsiales	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_94091_1	264198.Reut_B3798	1.14e-54	184.0	COG3181@1|root,COG3181@2|Bacteria,1R81N@1224|Proteobacteria,2VMV6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_253142_1	675635.Psed_4284	5.97e-38	139.0	COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B	-	-	-	-	-	-	-	-	-	-	-	-	LigB
k59_63797_1	1236908.wNo_00020	1.95e-136	390.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,47F5C@766|Rickettsiales	766|Rickettsiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_242278_1	570417.WP0996	1.48e-239	665.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,47EU0@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_94108_1	304371.MCP_1923	1.07e-48	165.0	COG2801@1|root,arCOG10339@2157|Archaea	2157|Archaea	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_44096_1	1236908.wNo_03880	1.66e-168	472.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,47F7J@766|Rickettsiales	766|Rickettsiales	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
k59_44096_2	1236908.wNo_03890	1.33e-161	460.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,47ETM@766|Rickettsiales	766|Rickettsiales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_223050_1	1123290.AUDQ01000018_gene972	5.26e-22	102.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26EDB@186818|Planococcaceae	91061|Bacilli	E	COG0747 ABC-type dipeptide transport system, periplasmic component	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_183604_1	7029.ACYPI42418-PA	3.28e-05	51.6	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_204423_1	1229909.NSED_08900	3.78e-64	202.0	COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
k59_313527_1	1301098.PKB_1200	9.13e-33	130.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	transport system involved in gliding motility, auxiliary component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_95473_1	1231391.AMZF01000063_gene1102	6.72e-92	286.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_313531_1	1000565.METUNv1_04058	9.11e-169	501.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,2KU82@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k59_214508_1	436308.Nmar_1099	4.73e-93	282.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_103876_1	983548.Krodi_0282	9.5e-12	64.3	COG0448@1|root,COG0448@2|Bacteria,4NDVJ@976|Bacteroidetes,1HYK5@117743|Flavobacteriia,37E9T@326319|Dokdonia	976|Bacteroidetes	G	Nucleotidyl transferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
k59_224215_1	570417.WP0101	3.42e-107	312.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k59_85400_1	388401.RB2150_02779	4.39e-38	136.0	COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,2TQNU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_233328_1	330214.NIDE0974	8.83e-31	112.0	COG4911@1|root,COG4911@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
k59_95495_1	172088.AUGA01000008_gene1089	6.1e-101	300.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,3JUUN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	addA	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_103885_1	330214.NIDE4031	2.76e-103	316.0	COG1217@1|root,COG1217@2|Bacteria,3J10A@40117|Nitrospirae	40117|Nitrospirae	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU
k59_165152_1	7159.AAEL018016-PA	2.67e-47	160.0	KOG4012@1|root,KOG4012@2759|Eukaryota,3A73W@33154|Opisthokonta,3BSV0@33208|Metazoa,3D97P@33213|Bilateria,420FB@6656|Arthropoda,3SNP5@50557|Insecta,454U2@7147|Diptera,45MQ0@7148|Nematocera	33208|Metazoa	B	Domain in histone families 1 and 5	HIST1H1A	GO:0000003,GO:0000228,GO:0000785,GO:0000790,GO:0000791,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005539,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005719,GO:0006325,GO:0006342,GO:0006355,GO:0006996,GO:0007276,GO:0007283,GO:0008150,GO:0008201,GO:0009889,GO:0009890,GO:0009892,GO:0009986,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010639,GO:0016043,GO:0016458,GO:0019219,GO:0019222,GO:0019953,GO:0022414,GO:0030100,GO:0031056,GO:0031057,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031399,GO:0031400,GO:0031490,GO:0031974,GO:0031981,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032504,GO:0032879,GO:0033043,GO:0033044,GO:0040029,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044703,GO:0045807,GO:0045814,GO:0045892,GO:0045934,GO:0048232,GO:0048259,GO:0048260,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048609,GO:0050789,GO:0050794,GO:0051049,GO:0051050,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051276,GO:0051704,GO:0060255,GO:0060627,GO:0065007,GO:0070013,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:1901363,GO:1901681,GO:1902275,GO:1902679,GO:1903506,GO:1903507,GO:1905268,GO:2000112,GO:2000113,GO:2001141,GO:2001251	-	ko:K11253,ko:K11275	ko05034,ko05202,ko05322,map05034,map05202,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Linker_histone
k59_214537_1	118161.KB235922_gene2022	9.54e-65	211.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3YK@1117|Cyanobacteria,3VNCI@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k59_303388_1	1236908.wNo_10540	4.47e-119	360.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,47EYR@766|Rickettsiales	766|Rickettsiales	O	Cytochrome c-type biogenesis protein ccmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
k59_303388_2	570417.WP0390	7.18e-75	244.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47FE1@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2
k59_113952_1	7029.ACYPI005556-PA	0.000468	50.1	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXBC@33208|Metazoa,3DBAC@33213|Bilateria,421D4@6656|Arthropoda,3SR4B@50557|Insecta,3ED43@33342|Paraneoptera	33154|Opisthokonta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_153510_1	7091.BGIBMGA011035-TA	1.76e-46	173.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VNK@33154|Opisthokonta,3CB3V@33208|Metazoa,3DSCG@33213|Bilateria,428FM@6656|Arthropoda,3SSDK@50557|Insecta,44A45@7088|Lepidoptera	33208|Metazoa	L	gag-polypeptide of LTR copia-type	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2
k59_213860_1	71139.XP_010026055.1	5.32e-06	54.3	COG2801@1|root,KOG0017@2759|Eukaryota,37R6P@33090|Viridiplantae,3G8BW@35493|Streptophyta	35493|Streptophyta	E	Uncharacterized protein K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	G-patch,RVT_1,RVT_3,Retrotrans_gag,rve
k59_103387_1	1236908.wNo_04270	4.15e-99	297.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,Kunitz_BPTI
k59_194009_1	1236908.wNo_05680	7.48e-152	428.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria,47FCQ@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
k59_54356_1	10224.XP_006825930.1	5.33e-15	84.7	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_293727_2	1121373.KB903625_gene3166	6.87e-11	65.1	COG0664@1|root,COG0745@1|root,COG0664@2|Bacteria,COG0745@2|Bacteria,4NFB1@976|Bacteroidetes,47JY7@768503|Cytophagia	976|Bacteroidetes	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,Response_reg,cNMP_binding
k59_263963_1	573370.DMR_13440	3.8e-28	117.0	COG0711@1|root,COG1216@1|root,COG0711@2|Bacteria,COG1216@2|Bacteria,1QP7Y@1224|Proteobacteria,430PF@68525|delta/epsilon subdivisions,2WW6M@28221|Deltaproteobacteria,2MAXB@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_2
k59_194014_1	7159.AAEL017571-PA	2.52e-28	121.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_84773_1	375286.mma_3355	6.97e-34	134.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,472QP@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_153523_1	570417.WP1223	1.31e-154	448.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,47EVM@766|Rickettsiales	766|Rickettsiales	V	Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP- binding domain (NBD) is responsible for energy generation (By similarity)	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_263967_1	436308.Nmar_1690	5.41e-126	370.0	COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_64590_1	570417.WP1017	0.0	901.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,47FEV@766|Rickettsiales	766|Rickettsiales	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	nuoN2	-	1.6.5.3	ko:K00343,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
k59_293740_1	7070.TC005030-PA	1.12e-38	148.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,MBD,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_124005_1	27923.ML08883a-PA	1.65e-40	157.0	KOG0977@1|root,KOG1075@1|root,KOG0977@2759|Eukaryota,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_14201_1	595537.Varpa_3005	1.31e-104	330.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_164507_1	1121335.Clst_0142	6.07e-21	98.6	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,3WIAE@541000|Ruminococcaceae	186801|Clostridia	L	PFAM Transposase, Mutator	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_44726_1	1229909.NSED_00170	9.04e-113	334.0	COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_213905_1	37682.EMT12132	5.66e-19	91.3	COG0513@1|root,COG2801@1|root,KOG2072@1|root,KOG0017@2759|Eukaryota,KOG0342@2759|Eukaryota,KOG2072@2759|Eukaryota,37Q3Y@33090|Viridiplantae,3GCXB@35493|Streptophyta,3KQFG@4447|Liliopsida,3IB7X@38820|Poales	35493|Streptophyta	J	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation	-	GO:0001732,GO:0002181,GO:0002183,GO:0002188,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005852,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043614,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0071540,GO:0071541,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03254	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	PCI
k59_223629_1	1288494.EBAPG3_13660	1.31e-102	305.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,3727I@32003|Nitrosomonadales	28216|Betaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_273917_1	436308.Nmar_1774	3.6e-45	154.0	COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_273917_2	436308.Nmar_1776	2.71e-66	209.0	COG1234@1|root,arCOG00501@2157|Archaea,41SF7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
k59_313025_2	443144.GM21_1578	3.96e-21	94.7	COG5000@1|root,COG5000@2|Bacteria,1QUG9@1224|Proteobacteria,42P6A@68525|delta/epsilon subdivisions,2WJZ4@28221|Deltaproteobacteria,43U4U@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_1
k59_113996_1	67593.Physo109041	3.28e-13	70.9	COG2801@1|root,KOG0017@2759|Eukaryota,3QH7I@4776|Peronosporales	67593.Physo109041|-	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114004_1	1449049.JONW01000006_gene3230	2.51e-62	202.0	COG3637@1|root,COG3637@2|Bacteria,1N7AR@1224|Proteobacteria	1224|Proteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	DUF481,OMP_b-brl
k59_203946_3	202698.XP_007378709.1	4.91e-17	79.3	2E1Q6@1|root,2S90D@2759|Eukaryota,3AAK0@33154|Opisthokonta,3P7RE@4751|Fungi,3V2P2@5204|Basidiomycota,229SC@155619|Agaricomycetes,3H5F7@355688|Agaricomycetes incertae sedis	4751|Fungi	S	Cupin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_14227_1	7029.ACYPI069967-PA	7.6e-35	130.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_313045_1	1502770.JQMG01000001_gene691	3.07e-57	184.0	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,2KKU3@206350|Nitrosomonadales	206350|Nitrosomonadales	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_253770_1	472759.Nhal_3001	3.16e-53	173.0	COG5654@1|root,COG5654@2|Bacteria,1N5WH@1224|Proteobacteria,1T1AI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM RES domain	-	-	-	-	-	-	-	-	-	-	-	-	RES
k59_253770_2	987059.RBXJA2T_12944	1.61e-27	103.0	COG5642@1|root,COG5642@2|Bacteria,1N1FN@1224|Proteobacteria,2VTKN@28216|Betaproteobacteria,1KNX7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
k59_134638_1	281687.CJA31164	2.93e-77	260.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,40S01@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_94866_1	436308.Nmar_0550	1.07e-97	291.0	COG0169@1|root,arCOG01033@2157|Archaea,41S6G@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
k59_24231_1	163164.WD_0509	2.3e-146	427.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,47F25@766|Rickettsiales	766|Rickettsiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_54431_1	7159.AAEL017299-PA	5.16e-61	216.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_293796_1	1349767.GJA_2105	2.7e-18	90.9	2CG4C@1|root,2Z8MQ@2|Bacteria,1R6PQ@1224|Proteobacteria,2VHKG@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_94893_1	1101190.ARWB01000001_gene1914	2.16e-42	151.0	COG3181@1|root,COG3181@2|Bacteria,1NP0J@1224|Proteobacteria,2U41R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_223682_2	436308.Nmar_1182	1.14e-65	212.0	COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
k59_73273_1	13037.EHJ73416	5.34e-40	165.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,41V5R@6656|Arthropoda,3SINZ@50557|Insecta	33208|Metazoa	S	RNase H	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_64680_1	1229909.NSED_01290	2.22e-68	211.0	COG0852@1|root,arCOG01551@2157|Archaea,41SJS@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase 27 kD subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_233776_1	1163617.SCD_n02941	6.86e-149	429.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_233776_2	85643.Tmz1t_0835	1.15e-09	59.3	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,2KWD2@206389|Rhodocyclales	206389|Rhodocyclales	NU	fimbrial biogenesis protein PilN	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_86095_1	7029.ACYPI071424-PA	1.2e-10	68.6	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,41V5R@6656|Arthropoda,3SINZ@50557|Insecta,3ECVU@33342|Paraneoptera	33208|Metazoa	S	RNase H	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_46049_1	344747.PM8797T_03559	5.57e-22	99.4	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	C5-epim_C,Wzy_C
k59_303878_1	7029.ACYPI009216-PA	1e-52	192.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_35938_1	1131266.ARWQ01000004_gene1476	2.86e-33	122.0	COG1028@1|root,arCOG01259@2157|Archaea,41SGH@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k59_35938_2	80637.XP_007767132.1	2e-12	68.2	COG3569@1|root,KOG0981@2759|Eukaryota,38C2E@33154|Opisthokonta,3NUJJ@4751|Fungi,3V04F@5204|Basidiomycota,22689@155619|Agaricomycetes	4751|Fungi	L	DNA Topoisomerase I (eukaryota)	TOP1	GO:0000018,GO:0000019,GO:0000070,GO:0000183,GO:0000228,GO:0000278,GO:0000280,GO:0000785,GO:0000790,GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006265,GO:0006271,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006725,GO:0006807,GO:0006810,GO:0006996,GO:0007049,GO:0007059,GO:0007076,GO:0007097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016458,GO:0016853,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022402,GO:0022616,GO:0030261,GO:0031298,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0040029,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046907,GO:0048285,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051276,GO:0051640,GO:0051641,GO:0051647,GO:0051649,GO:0051656,GO:0060255,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098813,GO:0140014,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903047,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
k59_145189_1	1229909.NSED_02705	1.07e-53	179.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_74159_1	570417.WP0741	8.2e-161	472.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,47EWT@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_5096_1	436308.Nmar_0253	6.42e-170	477.0	COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota	651137|Thaumarchaeota	C	oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
k59_25457_1	1536769.P40081_31040	4.72e-18	89.4	COG3385@1|root,COG3385@2|Bacteria,1TVXR@1239|Firmicutes,4HFC1@91061|Bacilli,26TYC@186822|Paenibacillaceae	91061|Bacilli	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_55699_1	1120980.JQKH01000017_gene1879	5.66e-122	369.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,2KPMW@206351|Neisseriales	206351|Neisseriales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_96223_1	7070.TC010973-PA	4.69e-31	127.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T04Y@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_86125_1	7668.SPU_024592-tr	6.11e-31	132.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_15407_1	7070.TC015470-PA	1.73e-55	196.0	COG2801@1|root,KOG1922@1|root,KOG0017@2759|Eukaryota,KOG1922@2759|Eukaryota,38C7D@33154|Opisthokonta,3BDNK@33208|Metazoa,3CX9J@33213|Bilateria,41VES@6656|Arthropoda,3SHX8@50557|Insecta	33208|Metazoa	TZ	Actin binding. It is involved in the biological process described with cellular component organization	FHDC1	GO:0001763,GO:0002009,GO:0002064,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005884,GO:0007275,GO:0007424,GO:0008092,GO:0008150,GO:0009653,GO:0009888,GO:0009987,GO:0015629,GO:0030154,GO:0030855,GO:0031110,GO:0031113,GO:0031941,GO:0032092,GO:0032271,GO:0032501,GO:0032502,GO:0032886,GO:0032991,GO:0033043,GO:0035146,GO:0035147,GO:0035150,GO:0035239,GO:0035295,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043393,GO:0044087,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0048468,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051128,GO:0051493,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061138,GO:0065007,GO:0065008,GO:0065009,GO:0070507,GO:0090066,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:1902903,GO:1904529,GO:1904531,GO:1904616,GO:1904618	-	-	-	-	-	-	-	-	-	-	Drf_FH3,FH2
k59_165896_1	1410620.SHLA_38c000530	7.62e-37	136.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,4B9XR@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_5117_2	436308.Nmar_0955	2.36e-63	202.0	COG1703@1|root,arCOG01226@2157|Archaea,41SFN@651137|Thaumarchaeota	651137|Thaumarchaeota	E	LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
k59_104464_1	436308.Nmar_0020	7.74e-158	446.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_25492_1	570417.WP1264	1.93e-171	486.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,47F3Y@766|Rickettsiales	766|Rickettsiales	EGP	Major facilitator	proP6	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
k59_25492_2	1236908.wNo_10800	1.42e-33	125.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,47F1T@766|Rickettsiales	766|Rickettsiales	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
k59_35992_1	1117958.PE143B_0130925	1.65e-12	69.7	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_125132_1	1236908.wNo_01030	2.64e-95	311.0	COG0457@1|root,COG0666@1|root,COG1672@1|root,COG2931@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG1672@2|Bacteria,COG2931@2|Bacteria,1MWRF@1224|Proteobacteria,2U9VQ@28211|Alphaproteobacteria,47F2N@766|Rickettsiales	766|Rickettsiales	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5,GerE,NB-ARC,TPR_12,TPR_2,TPR_7,TPR_8
k59_86155_1	1142394.PSMK_31620	9.45e-67	217.0	COG3039@1|root,COG3039@2|Bacteria,2J1M4@203682|Planctomycetes	203682|Planctomycetes	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_66152_1	163164.WD_0508	1.47e-112	329.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K20480	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_19,HTH_26,HTH_3,HTH_31
k59_145245_1	7739.XP_002587816.1	3.9e-05	50.4	KOG1075@1|root,KOG1075@2759|Eukaryota,3AAAT@33154|Opisthokonta,3BTXA@33208|Metazoa,3DBR2@33213|Bilateria	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_185589_1	1236908.wNo_11150	2.72e-194	565.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,47F0W@766|Rickettsiales	766|Rickettsiales	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_55742_1	497964.CfE428DRAFT_2899	9.93e-26	107.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_224986_1	1236908.wNo_02960	5.55e-92	295.0	COG3704@1|root,COG3704@2|Bacteria,1NIX6@1224|Proteobacteria,2UK4E@28211|Alphaproteobacteria,47F7M@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_224986_2	570417.WP0600	5.64e-82	266.0	COG3704@1|root,COG3704@2|Bacteria,1P5RF@1224|Proteobacteria	1224|Proteobacteria	U	Conjugal transfer protein	virB6	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_263500_1	7029.ACYPI53110-PA	4.85e-53	188.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_103039_1	570417.WP0649	2.29e-06	48.1	COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,47EUP@766|Rickettsiales	766|Rickettsiales	S	Phage portal protein, HK97 family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_223226_1	1236908.wNo_11110	2.27e-116	347.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,47EU4@766|Rickettsiales	766|Rickettsiales	S	metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
k59_123670_1	7176.CPIJ019173-PA	1.13e-16	82.4	2D8RZ@1|root,2TBAA@2759|Eukaryota,396FP@33154|Opisthokonta,3CAU4@33208|Metazoa,3DS1T@33213|Bilateria,4286G@6656|Arthropoda,3SSCU@50557|Insecta,457E2@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_164116_1	7159.AAEL017299-PA	3.9e-44	167.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_3626_1	7029.ACYPI062999-PA	6.23e-78	273.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_53941_1	717785.HYPMC_1710	1.35e-79	251.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_173723_1	1131266.ARWQ01000015_gene756	3.73e-115	343.0	COG1007@1|root,arCOG01540@2157|Archaea,41SDU@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase subunit 2 (Chain N)	-	-	1.5.98.3	ko:K22169	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Proton_antipo_M
k59_123675_1	7176.CPIJ006540-PA	5.31e-53	189.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_293378_1	7425.NV10089-PA	4.48e-28	127.0	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_242463_1	400682.PAC_15703323	3.07e-20	96.3	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_263532_1	7176.CPIJ011117-PA	1.4e-24	105.0	2D3X3@1|root,2ST2H@2759|Eukaryota,3ASQ8@33154|Opisthokonta,3C4UT@33208|Metazoa,3DQ6U@33213|Bilateria,428YX@6656|Arthropoda,3SXBZ@50557|Insecta,457HI@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_213519_1	570417.WP1144	4.2e-39	135.0	COG0819@1|root,COG0819@2|Bacteria,1PW65@1224|Proteobacteria,2VB7F@28211|Alphaproteobacteria,47GKS@766|Rickettsiales	766|Rickettsiales	K	TENA/THI-4/PQQC family	-	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
k59_213519_2	570417.WP1145	3.97e-53	173.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,47F0J@766|Rickettsiales	766|Rickettsiales	C	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3	coxC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_34323_3	1121406.JAEX01000031_gene2561	9.17e-06	48.5	COG2369@1|root,COG2369@2|Bacteria,1R8KM@1224|Proteobacteria,42NJS@68525|delta/epsilon subdivisions,2WK6P@28221|Deltaproteobacteria,2MCAS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Phage Mu protein F like protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Mu_F
k59_282915_1	1236908.wNo_04310	4.44e-52	175.0	COG4928@1|root,COG4928@2|Bacteria,1Q4X0@1224|Proteobacteria,2TTPM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
k59_282915_2	1236908.wNo_04320	1.35e-50	175.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2TQRS@28211|Alphaproteobacteria,47EVC@766|Rickettsiales	766|Rickettsiales	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
k59_213526_1	329726.AM1_6326	1.14e-82	256.0	COG3039@1|root,COG3039@2|Bacteria,1G7AF@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
k59_23898_1	570417.WP0137	4.31e-101	306.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,47ESZ@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_23898_2	1236908.wNo_10330	5.21e-06	47.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
k59_23898_3	570417.WP0135	6.71e-79	241.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,47FAP@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
k59_193702_1	7029.ACYPI21445-PA	0.000295	49.7	2EDMH@1|root,2SJ7R@2759|Eukaryota	7029.ACYPI21445-PA|-	S	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312714_1	1207063.P24_17347	1e-82	252.0	COG2755@1|root,COG2755@2|Bacteria,1QM85@1224|Proteobacteria,2U34V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_203636_1	6087.XP_004207470.1	1.21e-14	75.5	2CNBX@1|root,2QV3V@2759|Eukaryota,39W09@33154|Opisthokonta,3BH5J@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_72950_1	7029.ACYPI52857-PA	9.29e-105	361.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_153244_1	7159.AAEL017571-PA	1.69e-146	427.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_103096_1	281687.CJA15137	1.18e-22	105.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3DKJZ@33213|Bilateria,40GWW@6231|Nematoda,1KZYW@119089|Chromadorea,412EV@6236|Rhabditida	33208|Metazoa	K	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_3679_1	335283.Neut_0276	1.03e-84	258.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,371MG@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_203643_1	1459636.NTE_02916	0.000416	43.1	COG3485@1|root,2N56G@2157|Archaea	2157|Archaea	Q	Protocatechuate 3,4-dioxygenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
k59_312723_1	31234.CRE31176	4.05e-23	103.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3E5BZ@33213|Bilateria,40RH1@6231|Nematoda,1M8M8@119089|Chromadorea,4179I@6236|Rhabditida	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Chromo,Glycoprotein_B,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_34368_1	1207063.P24_17082	2.31e-34	128.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,2JQNZ@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
k59_34368_2	331869.BAL199_24954	1.28e-31	117.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,4BQHT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
k59_123713_1	570417.WP0903	2.74e-172	495.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,47EWQ@766|Rickettsiales	766|Rickettsiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
k59_143795_1	570417.WP0019	6.2e-72	217.0	COG2913@1|root,COG2913@2|Bacteria,1PSG5@1224|Proteobacteria,2VABF@28211|Alphaproteobacteria,47FSJ@766|Rickettsiales	766|Rickettsiales	J	SmpA / OmlA family	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
k59_64209_1	1229909.NSED_09745	2.38e-53	182.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_84471_2	62928.azo2767	2.6e-25	101.0	COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,2KWJR@206389|Rhodocyclales	206389|Rhodocyclales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
k59_123737_1	7029.ACYPI065353-PA	1.25e-39	154.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_293477_1	1173023.KE650771_gene20	1.21e-48	167.0	COG3153@1|root,COG3153@2|Bacteria,1GR93@1117|Cyanobacteria	1117|Cyanobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_223337_1	1229909.NSED_00185	5.93e-57	189.0	COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DnaJ central domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_293485_1	1229909.NSED_01225	1.39e-72	229.0	COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	-	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,Shikimate_DH
k59_312775_1	7029.ACYPI45214-PA	4.38e-46	169.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_263646_1	10224.XP_006825930.1	1.11e-28	120.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_303617_1	887898.HMPREF0551_1179	1.58e-74	245.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,1JZQS@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_95834_1	7029.ACYPI065353-PA	2.33e-32	129.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_165467_2	1079460.ATTQ01000008_gene957	7.83e-38	130.0	COG5605@1|root,COG5605@2|Bacteria,1RH8B@1224|Proteobacteria,2U9FI@28211|Alphaproteobacteria,4BFM4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	COX4_pro
k59_165467_3	1408164.MOLA814_00006	2.03e-68	213.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VKKS@28216|Betaproteobacteria	28216|Betaproteobacteria	C	oxidase, subunit	coxP	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_55311_1	580332.Slit_0426	6.58e-46	167.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,44W58@713636|Nitrosomonadales	28216|Betaproteobacteria	M	AsmA family	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
k59_174944_1	1131266.ARWQ01000015_gene746	2.58e-76	243.0	COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
k59_194904_1	7668.SPU_021823-tr	2.27e-67	236.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BSEH@33208|Metazoa,3D91U@33213|Bilateria	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_154362_1	436308.Nmar_0100	1.92e-32	123.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_154362_2	933801.Ahos_1384	4.11e-18	84.7	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
k59_294655_1	570417.WP0554	1.48e-104	336.0	COG0085@1|root,COG0086@1|root,COG0085@2|Bacteria,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,47ETY@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_313819_1	1288494.EBAPG3_6760	8.82e-103	322.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,372D7@32003|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_174953_1	570417.WP0647	4.44e-192	555.0	COG3164@1|root,COG3164@2|Bacteria,1QW23@1224|Proteobacteria,2TWM9@28211|Alphaproteobacteria,47GT3@766|Rickettsiales	766|Rickettsiales	S	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
k59_224597_1	7159.AAEL017571-PA	1.88e-43	166.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_254675_2	1120977.JHUX01000003_gene1413	6.82e-10	58.9	2ENCW@1|root,33G0D@2|Bacteria,1NMBV@1224|Proteobacteria,1SIRK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_224612_1	7029.ACYPI50013-PA	8.16e-28	117.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,4225E@6656|Arthropoda,3SQX6@50557|Insecta,3ECZ1@33342|Paraneoptera	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	MULE,RVT_1,gag-asp_proteas,rve
k59_264954_1	570417.WP0573	5.68e-183	519.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,47EYD@766|Rickettsiales	766|Rickettsiales	M	Cell division protein FtsI penicillin-binding protein 2	pbpA1	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
k59_35625_1	7668.SPU_016436-tr	7.34e-20	95.5	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_254690_1	570417.WP0735	7.76e-133	379.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria,47EWJ@766|Rickettsiales	766|Rickettsiales	C	Cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_274883_1	1077972.ARGLB_116_00530	3.15e-21	100.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_106294_1	998674.ATTE01000001_gene1965	5.71e-106	322.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1T58V@1236|Gammaproteobacteria,463WP@72273|Thiotrichales	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_88596_1	1229909.NSED_03500	9.34e-142	406.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine synthase	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_177488_1	589865.DaAHT2_2592	5.82e-42	155.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria,2MQ05@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
k59_227355_1	7159.AAEL017571-PA	1.98e-40	156.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_156634_1	7176.CPIJ018005-PA	9.39e-164	503.0	COG0653@1|root,2QS7I@2759|Eukaryota,39WSW@33154|Opisthokonta,3BMU5@33208|Metazoa,3D4KM@33213|Bilateria,41YIH@6656|Arthropoda,3SJK5@50557|Insecta	33208|Metazoa	U	SecA DEAD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_58158_1	7425.NV30389-PA	1.56e-28	112.0	2F3G8@1|root,2T4FJ@2759|Eukaryota,38Y72@33154|Opisthokonta,3C5TK@33208|Metazoa,3DM4J@33213|Bilateria,42320@6656|Arthropoda	7425.NV30389-PA|-	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_27621_1	570417.WP0577	3.81e-68	216.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,47EWC@766|Rickettsiales	766|Rickettsiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_75858_1	4787.PITG_16415T0	1.04e-29	115.0	2D2VC@1|root,2SP5Z@2759|Eukaryota,3QIC1@4776|Peronosporales	4776|Peronosporales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_245550_1	570417.WP1193	2.21e-179	510.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,47F0F@766|Rickettsiales	766|Rickettsiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_177497_1	1131266.ARWQ01000004_gene1455	2.27e-93	283.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_177497_2	1229909.NSED_07160	2.03e-19	84.7	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_286201_1	1236908.wNo_02080	4.23e-222	629.0	COG0438@1|root,COG0535@1|root,COG0438@2|Bacteria,COG0535@2|Bacteria,1NB81@1224|Proteobacteria,2U3FD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	wgeD	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
k59_177509_1	570417.WP1267	4.37e-150	426.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,47ETT@766|Rickettsiales	766|Rickettsiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_177509_2	292805.Wbm0756	2.3e-57	179.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2TU34@28211|Alphaproteobacteria,47F8P@766|Rickettsiales	766|Rickettsiales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_235494_1	436308.Nmar_1763	5.61e-105	315.0	COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_75866_1	7159.AAEL017571-PA	1.04e-54	197.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217467_1	1288494.EBAPG3_27080	3.44e-32	122.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,372JY@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_217467_2	314607.KB13_1	2.97e-22	93.6	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
k59_235506_1	27923.ML046335a-PA	6.36e-30	126.0	COG0480@1|root,KOG1075@1|root,KOG0467@2759|Eukaryota,KOG1075@2759|Eukaryota,38B8Q@33154|Opisthokonta,3BEBA@33208|Metazoa	33208|Metazoa	J	elongation factor Tu	EFTUD1	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019637,GO:0019693,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042256,GO:0042278,GO:0043021,GO:0043022,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044877,GO:0046039,GO:0046128,GO:0046483,GO:0055086,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	-	ko:K14536	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
k59_98975_1	4959.XP_002770268.1	6.39e-47	174.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3QNZW@4890|Ascomycota,3RTT4@4891|Saccharomycetes,47E39@766764|Debaryomycetaceae	4751|Fungi	L	Transposable element	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_7172_1	1095769.CAHF01000021_gene943	4.11e-61	194.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2VVC1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
k59_17598_1	7425.NV18932-PA	2.1e-72	246.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta,46N15@7399|Hymenoptera	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_267953_1	439235.Dalk_5087	5.25e-84	261.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales	1224|Proteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_68642_1	436308.Nmar_1706	1.39e-105	316.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
k59_68642_2	436308.Nmar_1707	0.000374	42.4	COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota	651137|Thaumarchaeota	F	thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_305504_2	570417.WP1093	1.48e-43	141.0	2EV1K@1|root,33NGP@2|Bacteria,1NQ8R@1224|Proteobacteria,2UKZ4@28211|Alphaproteobacteria,47FTC@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_305504_3	163164.WD_0160	3.67e-118	356.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,47F11@766|Rickettsiales	766|Rickettsiales	C	NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G)	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
k59_277494_1	7668.SPU_010235-tr	9.72e-22	102.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta	33154|Opisthokonta	L	biological adhesion	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,rve
k59_188138_1	420662.Mpe_A3264	2.03e-137	404.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_138741_1	7029.ACYPI37026-PA	2.81e-26	115.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	ko:K03102	ko04320,map04320	-	-	-	ko00000,ko00001,ko03019,ko03041	-	-	-	Exo_endo_phos_2,RVT_1
k59_88698_1	93220.LV28_10985	1.47e-32	124.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,1K3VV@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_88698_2	1005048.CFU_3954	3.4e-21	85.9	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,2VVQK@28216|Betaproteobacteria,474VM@75682|Oxalobacteraceae	28216|Betaproteobacteria	KL	Belongs to the transcriptional regulatory Fis family	fis	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
k59_88698_3	228410.NE0874	4.4e-35	129.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,371XV@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_138750_1	477184.KYC_02719	2.2e-42	150.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKCY@28216|Betaproteobacteria,3T3CF@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_38486_1	265072.Mfla_2102	7.26e-124	360.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,2KM77@206350|Nitrosomonadales	206350|Nitrosomonadales	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_305524_1	570417.WP1385	2.37e-84	274.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,47EX4@766|Rickettsiales	766|Rickettsiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18989	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718,M00720	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.30	-	-	ACR_tran
k59_117181_1	1236908.wNo_02080	7.24e-145	428.0	COG0438@1|root,COG0535@1|root,COG0438@2|Bacteria,COG0535@2|Bacteria,1NB81@1224|Proteobacteria,2U3FD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	wgeD	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
k59_286272_1	570417.WP1006	3e-111	336.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,47EWK@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_268004_1	7245.FBpp0256333	2.21e-20	100.0	2EU60@1|root,2SWDF@2759|Eukaryota,3AUSY@33154|Opisthokonta,3C446@33208|Metazoa,3DJ6C@33213|Bilateria,4240I@6656|Arthropoda,3SSF2@50557|Insecta	7245.FBpp0256333|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_88718_1	7719.XP_009859205.1	4.59e-44	164.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,48QAQ@7711|Chordata	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Glycoprotein_B,RVT_1,Retrotrans_gag,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_257292_1	28377.ENSACAP00000021771	1.04e-09	64.3	KOG1075@1|root,KOG1075@2759|Eukaryota,39RKB@33154|Opisthokonta,3BK61@33208|Metazoa,3CX3T@33213|Bilateria,4872C@7711|Chordata,495PJ@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1725,Exo_endo_phos,Exo_endo_phos_2,RVT_1
k59_68687_1	570417.WP0855	1.34e-200	557.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,47EYA@766|Rickettsiales	766|Rickettsiales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_68687_2	570417.WP0856	7.43e-184	511.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,47F6Y@766|Rickettsiales	766|Rickettsiales	L	COG0084 Mg-dependent DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_68687_3	570417.WP0857	2.33e-06	47.4	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2U7GI@28211|Alphaproteobacteria,47FC8@766|Rickettsiales	766|Rickettsiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_138771_1	6412.HelroP175615	3.67e-20	93.2	2CIKA@1|root,2S3RQ@2759|Eukaryota,3A5TG@33154|Opisthokonta,3BTMS@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RNase_H
k59_245646_1	570417.WP0858	4.7e-79	237.0	COG0703@1|root,COG0703@2|Bacteria,1QWJ3@1224|Proteobacteria,2TWYW@28211|Alphaproteobacteria,47GFE@766|Rickettsiales	766|Rickettsiales	E	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
k59_245646_2	1236908.wNo_07400	2.15e-108	312.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2U7GI@28211|Alphaproteobacteria,47FC8@766|Rickettsiales	766|Rickettsiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
k59_257297_1	7029.ACYPI067859-PA	2.39e-45	169.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta	33154|Opisthokonta	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_168608_1	420662.Mpe_A2431	3.53e-38	133.0	COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2VTZ3@28216|Betaproteobacteria,1KMNA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
k59_257301_1	215358.XP_010754587.1	4.18e-25	109.0	COG2801@1|root,KOG0017@2759|Eukaryota,3AHRY@33154|Opisthokonta,3BWYV@33208|Metazoa,3DEB7@33213|Bilateria,48IA5@7711|Chordata,49EHF@7742|Vertebrata	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_269288_1	228410.NE0615	3.58e-18	85.5	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,373JE@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
k59_128484_1	1227457.C451_05008	1.55e-26	108.0	COG1405@1|root,arCOG01981@2157|Archaea,2XSYE@28890|Euryarchaeota,23SMK@183963|Halobacteria	1227457.C451_05008|-	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_228716_1	1131266.ARWQ01000001_gene1075	7.65e-29	108.0	arCOG08730@1|root,arCOG08730@2157|Archaea,41SNH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_228716_2	436308.Nmar_1446	1.23e-37	128.0	COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_246637_1	10224.XP_006825930.1	1.99e-32	130.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_298551_1	570417.WP0503	1.2e-130	371.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,47G7C@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_298551_2	100901.wOo_04600	1.86e-09	57.8	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2TRMX@28211|Alphaproteobacteria,47F9M@766|Rickettsiales	766|Rickettsiales	S	Peptidase, M16 family	-	-	-	ko:K07263,ko:K07623	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_189330_1	1229909.NSED_01320	7.52e-160	461.0	COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_39649_1	7955.ENSDARP00000106282	2.52e-22	105.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_228741_1	90675.XP_010451516.1	5.04e-36	141.0	COG2801@1|root,KOG0017@2759|Eukaryota,37SNQ@33090|Viridiplantae,3GHRQ@35493|Streptophyta,3HVU8@3699|Brassicales	35493|Streptophyta	L	GAG-pre-integrase domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_157834_2	7176.CPIJ013333-PA	9.35e-20	87.0	KOG0494@1|root,KOG0494@2759|Eukaryota,3APVI@33154|Opisthokonta,3C1Z9@33208|Metazoa,3DIDN@33213|Bilateria,422YG@6656|Arthropoda,3SZ7U@50557|Insecta,458PX@7147|Diptera,45J6X@7148|Nematocera	33208|Metazoa	K	Homeodomain	-	-	-	-	-	-	-	-	-	-	-	-	Homeobox
k59_198997_1	330214.NIDE3263	1.42e-101	315.0	COG0317@1|root,COG0317@2|Bacteria,3J0CX@40117|Nitrospirae	40117|Nitrospirae	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_278710_2	7159.AAEL004637-PA	1.65e-34	124.0	2EZ1S@1|root,2T0FK@2759|Eukaryota,3AVPW@33154|Opisthokonta,3C493@33208|Metazoa,3DJIX@33213|Bilateria,423UQ@6656|Arthropoda	33208|Metazoa	S	FLYWCH zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4806,FLYWCH
k59_258385_1	1120999.JONM01000002_gene974	2.48e-54	184.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KPKT@206351|Neisseriales	206351|Neisseriales	C	NADH dehydrogenase I, chain M K00342	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_258385_2	640081.Dsui_3037	2.95e-68	223.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,2KUBM@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_389_1	570417.WP1262	3.68e-136	407.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,47EW5@766|Rickettsiales	766|Rickettsiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_259759_1	398767.Glov_3358	1e-08	60.8	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
k59_259759_2	596152.DesU5LDRAFT_0065	7.48e-19	86.7	COG0535@1|root,COG0535@2|Bacteria,1N633@1224|Proteobacteria,4361J@68525|delta/epsilon subdivisions,2X0J6@28221|Deltaproteobacteria,2MCHX@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_269683_1	330214.NIDE2649	2.06e-25	109.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
k59_70135_1	570417.WP0220	1.35e-112	350.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,47G6H@766|Rickettsiales	766|Rickettsiales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_110130_1	1410619.SRDD_27080	1.76e-41	147.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
k59_239691_1	7668.SPU_025846-tr	4.42e-55	209.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BHS6@33208|Metazoa,3E42R@33213|Bilateria	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve,zf-CCHC
k59_239691_2	7176.CPIJ001145-PA	1.01e-15	84.7	KOG4193@1|root,KOG4193@2759|Eukaryota,39WZ5@33154|Opisthokonta,3BM8U@33208|Metazoa,3D5FM@33213|Bilateria,41VRK@6656|Arthropoda,3SGIA@50557|Insecta,4561G@7147|Diptera	33208|Metazoa	T	7 transmembrane receptor (Secretin family)	-	-	-	ko:K04599	-	-	-	-	ko00000,ko04030	-	-	-	7tm_2
k59_309572_5	7176.CPIJ019211-PA	1.01e-10	65.1	2E1I0@1|root,2S8UZ@2759|Eukaryota,3A9DK@33154|Opisthokonta,3BV6P@33208|Metazoa,3DC7S@33213|Bilateria,4233M@6656|Arthropoda,3SPZI@50557|Insecta,457QA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_259761_1	570417.WP0262	6.05e-57	194.0	COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria	1224|Proteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
k59_279644_1	7176.CPIJ008169-PA	3.72e-27	104.0	2E4T1@1|root,2SBN4@2759|Eukaryota,3ADG2@33154|Opisthokonta,3BWF0@33208|Metazoa,3DCTZ@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_189940_1	7029.ACYPI22536-PA	1.21e-14	75.1	2D4HY@1|root,2SV82@2759|Eukaryota,3ATP4@33154|Opisthokonta,3C40G@33208|Metazoa,3DJMG@33213|Bilateria,423M9@6656|Arthropoda,3SSF1@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_219830_1	330214.NIDE0228	1.5e-94	294.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341,ko:K05568,ko:K12139	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_179957_1	135651.CBN15281	2.04e-23	103.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3C0WJ@33208|Metazoa,3E5AA@33213|Bilateria,40RE5@6231|Nematoda,1M8IG@119089|Chromadorea,40WYR@6236|Rhabditida	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17
k59_249759_2	886293.Sinac_6831	1.21e-63	207.0	COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes	203682|Planctomycetes	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_20311_1	1229909.NSED_08255	1.84e-112	323.0	arCOG08676@1|root,arCOG08676@2157|Archaea,41SCF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Archaeal ammonia monooxygenase subunit A (AmoA)	-	-	1.14.18.3,1.14.99.39	ko:K10944	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Archaeal_AmoA
k59_70155_1	457415.HMPREF1006_02874	1.41e-23	102.0	COG1638@1|root,COG1638@2|Bacteria,3TAE1@508458|Synergistetes	508458|Synergistetes	G	transporter solute receptor, DctP family	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_60268_1	7029.ACYPI52857-PA	2.21e-37	149.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_120134_1	1298867.AUES01000001_gene1607	1.72e-89	272.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,3JQU4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_209907_1	163164.WD_0230	1.25e-92	283.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,47FX0@766|Rickettsiales	766|Rickettsiales	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
k59_50336_1	420662.Mpe_A2227	1.14e-92	285.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KNDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_269731_1	1229909.NSED_00020	1.13e-65	209.0	COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
k59_269731_2	436308.Nmar_0066	4.32e-14	71.2	COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
k59_10411_1	686340.Metal_1349	1.07e-155	445.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1XG8N@135618|Methylococcales	135618|Methylococcales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_209915_1	7668.SPU_021533-tr	1.41e-24	102.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_80352_1	28042.GU90_14960	1.48e-53	181.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4E0V5@85010|Pseudonocardiales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
k59_60289_1	7029.ACYPI32766-PA	1.95e-39	142.0	2E7RP@1|root,2SEAH@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,Retrotran_gag_2
k59_80355_1	504832.OCAR_7523	1.91e-85	267.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_70173_1	1236959.BAMT01000016_gene2804	9.95e-70	219.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,2KM6N@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_70173_2	40373.F991_02793	0.000434	42.7	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,3NK31@468|Moraxellaceae	1236|Gammaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_2160,iPC815.YPO2428	B3_4,B5,FDX-ACB,tRNA_bind
k59_20357_1	1144310.PMI07_001133	1.2e-64	209.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,4BG3R@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_309637_1	666684.AfiDRAFT_2647	2.21e-40	147.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2TRFU@28211|Alphaproteobacteria,3K2UM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_13905	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_463_1	580332.Slit_1737	2.49e-60	203.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,44V7H@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_463_2	29581.BW37_02304	4.8e-53	170.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,473AV@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
k59_190768_1	1229909.NSED_01660	3.66e-46	157.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_31212_1	7091.BGIBMGA011035-TA	6.68e-96	313.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VNK@33154|Opisthokonta,3CB3V@33208|Metazoa,3DSCG@33213|Bilateria,428FM@6656|Arthropoda,3SSDK@50557|Insecta,44A45@7088|Lepidoptera	33208|Metazoa	L	gag-polypeptide of LTR copia-type	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2
k59_190770_3	1236908.wNo_03390	1.92e-18	83.6	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,47F1A@766|Rickettsiales	766|Rickettsiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_100796_2	1288494.EBAPG3_730	1.24e-34	133.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,371VE@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_61054_1	1131266.ARWQ01000001_gene1157	2.34e-19	80.9	arCOG10523@1|root,arCOG10523@2157|Archaea,41SSZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_61054_2	1131266.ARWQ01000001_gene1158	2.09e-97	286.0	COG0049@1|root,arCOG04254@2157|Archaea,41S6U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_220585_2	570417.WP0015	1.33e-47	154.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,47FMZ@766|Rickettsiales	766|Rickettsiales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_21145_1	330214.NIDE0701	3.59e-94	283.0	COG0142@1|root,COG0142@2|Bacteria,3J0H1@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_310295_1	436308.Nmar_1731	8.63e-89	271.0	COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_161006_1	1131266.ARWQ01000015_gene757	4.37e-97	302.0	COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_41188_1	6087.XP_004211823.1	6.67e-30	125.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa	33208|Metazoa	G	mannose metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_21154_1	1229909.NSED_01670	5.78e-103	326.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_240320_1	570417.WP1385	1.97e-37	139.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,47EX4@766|Rickettsiales	766|Rickettsiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18989	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718,M00720	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.30	-	-	ACR_tran
k59_210644_1	1038860.AXAP01000007_gene6166	3.87e-46	160.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,3JT5T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
k59_170894_2	570417.WP0723	5.75e-148	426.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TSV9@28211|Alphaproteobacteria,47EYE@766|Rickettsiales	766|Rickettsiales	E	Amino acid permease	potE	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_150742_1	1120983.KB894577_gene3578	6.12e-106	315.0	COG0673@1|root,COG0673@2|Bacteria,1PGFP@1224|Proteobacteria,2V8DN@28211|Alphaproteobacteria,1JQA3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_250548_1	497964.CfE428DRAFT_0179	3.06e-55	189.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_200818_2	547144.HydHO_0590	2.9e-30	108.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
k59_200818_3	243159.AFE_2601	3.88e-13	68.6	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RQS1@1236|Gammaproteobacteria,2NCAJ@225057|Acidithiobacillales	225057|Acidithiobacillales	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_41213_1	1131266.ARWQ01000001_gene1152	7.71e-25	97.1	arCOG08745@1|root,arCOG08745@2157|Archaea,41SU1@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_41213_2	436308.Nmar_0374	2.12e-26	100.0	COG2058@1|root,arCOG04287@2157|Archaea,41SP0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
k59_5712_2	570417.WP0016	1.62e-298	814.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,47EZQ@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
k59_186340_1	1229909.NSED_00030	4.64e-44	160.0	COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_66999_1	69319.XP_008557127.1	3.13e-102	325.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_266065_1	1459636.NTE_03147	6.46e-85	263.0	COG0484@1|root,arCOG06880@1|root,arCOG02846@2157|Archaea,arCOG06880@2157|Archaea,41SCZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DnaJ central domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
k59_244286_1	7029.ACYPI061330-PA	6.34e-90	302.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_86864_1	1229909.NSED_01260	2.58e-101	308.0	COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18604	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
k59_244288_1	69319.XP_008553384.1	4.07e-20	95.9	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_295716_1	7029.ACYPI29951-PA	6.96e-24	107.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_175960_3	570417.WP0952	2.7e-128	365.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,47F5K@766|Rickettsiales	766|Rickettsiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
k59_105053_2	1396141.BATP01000019_gene1718	2.39e-30	122.0	COG3225@1|root,COG3225@2|Bacteria,46UZA@74201|Verrucomicrobia,2IUBV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
k59_295723_1	1236908.wNo_02040	9.72e-120	349.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,47FV3@766|Rickettsiales	766|Rickettsiales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_46890_1	926560.KE387023_gene2472	1.28e-105	325.0	COG1523@1|root,COG1523@2|Bacteria,1WJJM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
k59_205769_1	1229909.NSED_09500	4.97e-144	422.0	COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
k59_295725_1	312153.Pnuc_1388	1.59e-53	179.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	acd12	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_215935_1	436308.Nmar_0397	9.22e-91	274.0	COG0448@1|root,arCOG00912@2157|Archaea,41SEY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_275917_1	2340.JV46_28930	4.79e-44	148.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
k59_275917_2	243159.AFE_2543	1.6e-06	49.7	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,1RY3C@1236|Gammaproteobacteria,2NCK4@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
k59_36769_1	570417.WP0803	2.32e-70	222.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,47FMF@766|Rickettsiales	766|Rickettsiales	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
k59_26141_1	436308.Nmar_0869	2.97e-103	312.0	COG0154@1|root,arCOG01717@2157|Archaea,41SCW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_115686_1	1231190.NA8A_02520	7.22e-20	84.7	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9DU@28211|Alphaproteobacteria,43KGH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_196089_1	27923.ML08883a-PA	1.67e-46	171.0	KOG0977@1|root,KOG1075@1|root,KOG0977@2759|Eukaryota,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_67059_1	388051.AUFE01000001_gene1907	2.12e-107	321.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
k59_205782_1	28564.XP_002488353.1	2.02e-13	72.8	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3QNZW@4890|Ascomycota,20FR9@147545|Eurotiomycetes,3SBVI@5042|Eurotiales	4751|Fungi	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_304473_1	436308.Nmar_1767	7.1e-68	219.0	COG0484@1|root,arCOG02846@2157|Archaea,41T1F@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
k59_275946_1	570417.WP0069	2.37e-125	364.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,47F15@766|Rickettsiales	766|Rickettsiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_155993_1	1236908.wNo_06250	1.24e-137	390.0	COG4649@1|root,COG4649@2|Bacteria,1P2GI@1224|Proteobacteria,2U5KS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
k59_296558_1	570417.WP0811	6.5e-149	423.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,47F17@766|Rickettsiales	766|Rickettsiales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
k59_167682_1	1000565.METUNv1_00612	1.03e-48	165.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,2KVMS@206389|Rhodocyclales	206389|Rhodocyclales	OU	signal peptide peptidase	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_167682_2	1408473.JHXO01000007_gene964	6.62e-12	65.1	COG0313@1|root,COG0313@2|Bacteria,4NDXE@976|Bacteroidetes,2FN1A@200643|Bacteroidia	976|Bacteroidetes	H	Psort location Cytoplasmic, score 8.96	rsmI_1	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
k59_37747_2	1229909.NSED_08645	6.22e-101	306.0	COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_206458_1	436308.Nmar_1793	1.03e-101	306.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_155998_1	570417.WP1347	1.33e-63	202.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U8QV@28211|Alphaproteobacteria,47G0S@766|Rickettsiales	766|Rickettsiales	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_155998_2	570417.WP1347	1.2e-61	197.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U8QV@28211|Alphaproteobacteria,47G0S@766|Rickettsiales	766|Rickettsiales	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_276740_1	1229909.NSED_08790	1.94e-08	53.1	COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota	651137|Thaumarchaeota	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
k59_276740_2	1229909.NSED_08785	1.86e-29	107.0	COG2118@1|root,arCOG04179@2157|Archaea,41SR0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
k59_276740_3	436308.Nmar_1622	2.74e-09	57.4	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_146623_1	1217718.ALOU01000038_gene3330	1.64e-95	292.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
k59_137834_1	1229909.NSED_02970	1.98e-95	288.0	COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Chlorophyllase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_315542_1	7029.ACYPI29951-PA	3.66e-22	102.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_116384_1	6500.XP_005105874.1	2.79e-07	58.9	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria	33208|Metazoa	G	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_276767_1	667632.KB890220_gene2806	8.16e-80	254.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,1K1H9@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD4	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_244979_1	1229909.NSED_00215	1.95e-107	330.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_234985_1	570417.WP0001	1.99e-189	534.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,47EXY@766|Rickettsiales	766|Rickettsiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_75320_2	1163617.SCD_n01392	4.77e-16	77.8	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	negative regulator of sigma E activity	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_137883_1	1229909.NSED_02680	1.49e-82	257.0	COG1258@1|root,arCOG01015@2157|Archaea,41SHC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	-	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	-
k59_266996_1	570417.WP1159	1.55e-29	116.0	COG1196@1|root,COG1196@2|Bacteria,1R0YX@1224|Proteobacteria	1224|Proteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_206479_1	7070.TC011220-PA	3.53e-246	751.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_47843_1	867845.KI911784_gene598	3.79e-15	76.6	COG0507@1|root,COG0507@2|Bacteria,2G626@200795|Chloroflexi,376JS@32061|Chloroflexia	32061|Chloroflexia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
k59_137895_1	1236908.wNo_08310	1.2e-47	152.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,47FNK@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k59_137895_2	570417.WP1176	1.62e-74	223.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,47FD2@766|Rickettsiales	766|Rickettsiales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k59_98133_1	7029.ACYPI26971-PA	5.11e-34	136.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_276813_1	205914.HS_1381	8.36e-18	87.8	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	ko:K13614,ko:K15674	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acetyltransf_1,DinB_2,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
k59_296631_1	1229909.NSED_09395	6.8e-71	217.0	COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Dual specificity phosphatase, catalytic domain	-	-	3.1.3.16,3.1.3.48	ko:K14165	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	DSPc
k59_296631_2	1229909.NSED_09385	3.01e-21	84.0	arCOG08748@1|root,arCOG08748@2157|Archaea,41SV7@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_296631_3	1229909.NSED_09360	1.45e-87	261.0	arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_296631_4	436308.Nmar_1757	6.13e-36	124.0	COG1761@1|root,arCOG04111@2157|Archaea,41SV9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	RNA polymerase Rpb3/Rpb11 dimerisation domain	-	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
k59_296631_5	436308.Nmar_1756	2.29e-40	136.0	COG1594@1|root,arCOG00579@2157|Archaea,41SS3@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	TFIIS_C
k59_296631_6	1229909.NSED_09345	1.03e-102	302.0	COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
k59_67996_1	1236908.wNo_07490	1.37e-132	386.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,47F18@766|Rickettsiales	766|Rickettsiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_114945_2	1125973.JNLC01000012_gene939	2.94e-73	236.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2U4TN@28211|Alphaproteobacteria,3K33T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K13634,ko:K13635	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_165809_1	7176.CPIJ014087-PA	4.13e-05	53.1	KOG1721@1|root,KOG1721@2759|Eukaryota,395NC@33154|Opisthokonta,3CA5V@33208|Metazoa,3DRAR@33213|Bilateria,42CH3@6656|Arthropoda,3STMY@50557|Insecta,4586Y@7147|Diptera,45JZG@7148|Nematocera	33208|Metazoa	S	Zinc-finger associated domain (zf-AD)	-	-	-	-	-	-	-	-	-	-	-	-	THAP,zf-AD,zf-C2H2
k59_265198_2	570417.WP0151	2.35e-142	401.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2TT09@28211|Alphaproteobacteria,47F5T@766|Rickettsiales	766|Rickettsiales	O	C-terminal domain of 1-Cys peroxiredoxin	tdpX1	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
k59_265198_3	570417.WP0150	9.92e-13	66.6	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,47EZ4@766|Rickettsiales	766|Rickettsiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_5055_1	1131266.ARWQ01000001_gene1262	1.42e-60	197.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
k59_154631_1	570417.WP1211	2.22e-101	295.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,47FA3@766|Rickettsiales	766|Rickettsiales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
k59_165816_1	1239962.C943_02795	6.17e-39	150.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HYR
k59_175205_1	1459636.NTE_02809	7.2e-24	100.0	COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
k59_175205_2	1131266.ARWQ01000002_gene522	7.24e-48	155.0	arCOG08655@1|root,arCOG08655@2157|Archaea,41SR9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_254947_1	1236908.wNo_08010	6.82e-57	176.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,47FKP@766|Rickettsiales	766|Rickettsiales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
k59_254947_2	1236908.wNo_08020	3.69e-39	139.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,47F4B@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_154636_1	570417.WP0936	1.12e-110	323.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,47F1S@766|Rickettsiales	766|Rickettsiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
k59_195206_1	748247.AZKH_2843	2.79e-11	63.5	COG3073@1|root,COG3073@2|Bacteria,1QANZ@1224|Proteobacteria,2VVPR@28216|Betaproteobacteria,2KXA7@206389|Rhodocyclales	206389|Rhodocyclales	T	Anti sigma-E protein RseA	rseA	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
k59_195206_2	323848.Nmul_A1746	8.76e-78	236.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,371U7@32003|Nitrosomonadales	28216|Betaproteobacteria	K	RNA polymerase sigma factor	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k59_294941_1	570417.WP0654	2.04e-133	387.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,47FVU@766|Rickettsiales	766|Rickettsiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k59_125064_1	1439940.BAY1663_04106	5.25e-40	142.0	2BRG7@1|root,32KF4@2|Bacteria,1REC2@1224|Proteobacteria,1SVQK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
k59_254956_1	314230.DSM3645_29232	6.39e-97	294.0	COG3385@1|root,COG3385@2|Bacteria,2IZE5@203682|Planctomycetes	203682|Planctomycetes	L	COG5659 FOG Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_284301_1	436308.Nmar_1034	6.6e-67	214.0	COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_284301_2	1229909.NSED_06095	6.8e-21	90.1	COG1980@1|root,arCOG04180@2157|Archaea,41S67@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
k59_96189_1	1131266.ARWQ01000015_gene756	6.79e-90	278.0	COG1007@1|root,arCOG01540@2157|Archaea,41SDU@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase subunit 2 (Chain N)	-	-	1.5.98.3	ko:K22169	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Proton_antipo_M
k59_96189_2	1229909.NSED_01335	5.55e-40	140.0	COG0142@1|root,arCOG01727@2157|Archaea,41SC6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_294950_1	1236908.wNo_07850	1.61e-131	385.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,47F34@766|Rickettsiales	766|Rickettsiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_314839_2	1500897.JQNA01000002_gene5368	3.23e-08	59.3	COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,2VQER@28216|Betaproteobacteria,1K5SX@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	gst3	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3
k59_36827_2	713586.KB900536_gene2525	6.66e-18	82.4	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_255723_1	570417.WP0340	2.17e-25	99.8	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
k59_255723_2	570417.WP0414	2.43e-116	338.0	COG0666@1|root,COG0666@2|Bacteria,1RAMN@1224|Proteobacteria	1224|Proteobacteria	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4
k59_74717_1	7159.AAEL007489-PA	4.64e-21	97.4	KOG0255@1|root,KOG0255@2759|Eukaryota,39UVP@33154|Opisthokonta,3BMGJ@33208|Metazoa,3D0VW@33213|Bilateria,41WTF@6656|Arthropoda,3SGYS@50557|Insecta,450JT@7147|Diptera,45CUW@7148|Nematocera	33208|Metazoa	S	Sugar (and other) transporter	-	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016298,GO:0016787,GO:0016788,GO:0031224,GO:0044238,GO:0044425,GO:0071704	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_285035_1	713586.KB900536_gene2631	2.15e-07	50.4	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales	135613|Chromatiales	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_285035_2	272560.BPSL3048	8.34e-52	169.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1K37J@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_255729_1	443152.MDG893_15295	1.3e-19	89.4	COG3181@1|root,COG3181@2|Bacteria,1N3HN@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_255729_2	1509405.GV67_12595	7.29e-21	91.7	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,4BGGN@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
k59_145960_1	1131266.ARWQ01000005_gene787	8.22e-225	635.0	COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
k59_215998_1	436308.Nmar_0043	1.12e-71	226.0	COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
k59_215998_2	436308.Nmar_0044	4.27e-70	219.0	COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
k59_155401_1	7425.NV22981-PA	3e-32	132.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	1.1.1.206	ko:K08081,ko:K21596	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R02832	RC00144	ko00000,ko00001,ko01000,ko03000	-	-	-	Exo_endo_phos_2,RVT_1,RVT_3
k59_86974_1	10224.XP_006812352.1	1.12e-27	119.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_244362_1	1236908.wNo_05720	4.62e-93	272.0	COG3543@1|root,COG3543@2|Bacteria,1RI03@1224|Proteobacteria,2U9SV@28211|Alphaproteobacteria,47FNG@766|Rickettsiales	766|Rickettsiales	S	Protein of unknown function (DUF1284)	-	-	-	ko:K09706	-	-	-	-	ko00000	-	-	-	DUF1284
k59_186497_1	436308.Nmar_0115	5.33e-146	424.0	COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_56710_1	1089548.KI783301_gene3307	2.32e-35	123.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,4IRDZ@91061|Bacilli	91061|Bacilli	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_105143_1	292415.Tbd_1771	3e-15	75.9	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,1KSHW@119069|Hydrogenophilales	119069|Hydrogenophilales	L	DHH family	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_216029_1	570417.WP0471	3.15e-214	596.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2U2B9@28211|Alphaproteobacteria,47GPW@766|Rickettsiales	766|Rickettsiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_36897_1	1229909.NSED_08780	1.98e-158	450.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
k59_137018_1	7070.TC001899-PA	6.11e-60	214.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SQXX@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_285068_1	6669.EFX67959	2.64e-07	57.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39MTI@33154|Opisthokonta,3CPD9@33208|Metazoa,3E5HV@33213|Bilateria,42AJ0@6656|Arthropoda	2759|Eukaryota	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2
k59_276030_1	436308.Nmar_0419	6.01e-13	68.6	COG1478@1|root,arCOG02714@2157|Archaea,41SHA@651137|Thaumarchaeota	651137|Thaumarchaeota	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
k59_276030_2	1229909.NSED_02185	4.86e-115	340.0	COG0065@1|root,arCOG01698@2157|Archaea,41S7A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_255778_1	31234.CRE17270	7.76e-81	271.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,411FR@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC
k59_137021_1	436308.Nmar_0296	9.58e-124	369.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_56718_1	335543.Sfum_3200	2.11e-46	164.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MRB7@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_216050_1	570967.JMLV01000010_gene1250	6.79e-16	81.3	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VF1H@28211|Alphaproteobacteria,2JQWD@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_105170_1	1288494.EBAPG3_2020	2.27e-90	274.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,371SF@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_137041_1	1163617.SCD_n00577	7.42e-34	121.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
k59_137041_2	1163617.SCD_n00576	2.05e-54	177.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
k59_276052_1	1236908.wNo_10640	3.36e-82	273.0	COG0666@1|root,COG1672@1|root,COG5635@1|root,COG0666@2|Bacteria,COG1672@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5,DUF4062,NACHT,NB-ARC,TPR_12
k59_225901_1	1105367.CG50_14485	2.02e-78	242.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_216062_1	400682.PAC_15723685	8.4e-36	141.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_176106_1	570417.WP0179	3.45e-144	412.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	anK3	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,SUFU
k59_166929_1	6334.EFV50733	8.57e-21	96.3	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria	33208|Metazoa	J	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_314917_1	1236908.wNo_05980	7.26e-64	195.0	2C7TH@1|root,32RJS@2|Bacteria,1MZK8@1224|Proteobacteria,2UC2R@28211|Alphaproteobacteria,47FU2@766|Rickettsiales	766|Rickettsiales	S	ETC complex I subunit conserved region	-	-	-	-	-	-	-	-	-	-	-	-	ETC_C1_NDUFA4
k59_5879_1	330214.NIDE3942	3.35e-109	327.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_97327_1	570417.WP0520	2.52e-103	322.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,47F2F@766|Rickettsiales	766|Rickettsiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
k59_115817_1	570417.WP0356	1.05e-144	447.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,47F1Y@766|Rickettsiales	766|Rickettsiales	E	NAD-specific glutamate dehydrogenase	gdhB	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_314935_1	1229909.NSED_06845	4.83e-42	149.0	COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_314935_2	1229909.NSED_06855	7.73e-36	124.0	COG2092@1|root,arCOG01988@2157|Archaea,41SS1@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
k59_225926_1	7668.SPU_003319-tr	2.04e-25	109.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3E64E@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_38080_1	1229909.NSED_02155	1.35e-10	60.1	COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
k59_38080_2	1229909.NSED_02150	1.12e-88	279.0	COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota	651137|Thaumarchaeota	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
k59_235204_1	1453496.AT03_01460	2.67e-18	87.4	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
k59_245226_1	570417.WP0697	4.94e-29	108.0	COG5424@1|root,COG5424@2|Bacteria,1PV6D@1224|Proteobacteria,2V6N7@28211|Alphaproteobacteria,47F6F@766|Rickettsiales	766|Rickettsiales	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
k59_245226_2	1236908.wNo_03620	2.27e-67	205.0	COG1539@1|root,COG1539@2|Bacteria,1NIXX@1224|Proteobacteria,2UXW2@28211|Alphaproteobacteria,47GMA@766|Rickettsiales	766|Rickettsiales	H	Dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
k59_48164_1	330214.NIDE3713	4.53e-143	420.0	COG2759@1|root,COG2759@2|Bacteria,3J0CI@40117|Nitrospirae	40117|Nitrospirae	F	Formate--tetrahydrofolate ligase	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_217072_1	1131266.ARWQ01000008_gene294	2.04e-61	199.0	COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota	651137|Thaumarchaeota	M	glycosyl transferase family	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
k59_217072_2	436308.Nmar_0243	3.22e-64	215.0	COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
k59_277107_1	1131266.ARWQ01000008_gene316	2.18e-06	45.8	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
k59_277107_2	1131266.ARWQ01000008_gene315	2.52e-44	153.0	COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
k59_27258_1	1163617.SCD_n02486	1.58e-112	333.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_168093_1	570417.WP0773	4.18e-190	541.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_256819_1	7029.ACYPI52857-PA	6.65e-78	272.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_206803_1	1131266.ARWQ01000032_gene1006	8.8e-44	150.0	arCOG08785@1|root,arCOG08785@2157|Archaea,41SVD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	-
k59_206803_2	1131266.ARWQ01000005_gene822	5.95e-48	169.0	COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota	2157|Archaea	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
k59_106033_1	977880.RALTA_A2752	5.3e-65	208.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHEF@28216|Betaproteobacteria,1KGVI@119060|Burkholderiaceae	28216|Betaproteobacteria	P	abc transporter	dppB2	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_245263_1	1131266.ARWQ01000012_gene1605	1.03e-76	234.0	COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
k59_88261_1	330214.NIDE0346	4.8e-62	202.0	COG3016@1|root,COG3016@2|Bacteria	2|Bacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	phuW	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
k59_187692_1	436308.Nmar_1794	7e-118	370.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_267465_1	570417.WP1109	1.35e-178	508.0	COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	alanine symporter	alsT	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
k59_296943_1	570417.WP0591	1.87e-287	787.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,47EVF@766|Rickettsiales	766|Rickettsiales	S	Belongs to the peptidase M16 family	mpp	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
k59_227042_1	436308.Nmar_1416	5.94e-28	107.0	COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
k59_227042_2	436308.Nmar_1415	5.51e-46	160.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
k59_147007_1	1229909.NSED_08645	1.82e-66	214.0	COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_168117_1	264730.PSPPH_4526	1.35e-118	371.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Z8WH@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9,Reg_prop
k59_267477_1	1441930.Z042_14665	7.87e-50	171.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,4036M@613|Serratia	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_277146_1	2903.EOD16267	1.31e-13	72.0	COG0133@1|root,COG0159@1|root,KOG1395@2759|Eukaryota,KOG4175@2759|Eukaryota	2759|Eukaryota	E	tryptophan synthase activity	TRP5	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009606,GO:0009607,GO:0009617,GO:0009628,GO:0009629,GO:0009630,GO:0009651,GO:0009683,GO:0009684,GO:0009719,GO:0009725,GO:0009735,GO:0009850,GO:0009851,GO:0009941,GO:0009987,GO:0010033,GO:0010817,GO:0016020,GO:0016043,GO:0016053,GO:0016829,GO:0016830,GO:0016832,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0019904,GO:0031967,GO:0031975,GO:0032787,GO:0033036,GO:0033037,GO:0033554,GO:0033984,GO:0034641,GO:0034754,GO:0042221,GO:0042401,GO:0042430,GO:0042435,GO:0042445,GO:0042446,GO:0042545,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045229,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051179,GO:0051641,GO:0051704,GO:0051707,GO:0051716,GO:0052386,GO:0052482,GO:0052542,GO:0052543,GO:0052544,GO:0052545,GO:0065007,GO:0065008,GO:0070727,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0098542,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.2.8,4.2.1.20	ko:K01694,ko:K01695,ko:K01696,ko:K10882,ko:K13222	ko00260,ko00400,ko00402,ko01100,ko01110,ko01130,ko01230,ko03440,ko03460,map00260,map00400,map00402,map01100,map01110,map01130,map01230,map03440,map03460	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	PALP,Trp_syntA
k59_277146_2	50960.LS81_00250	1.21e-20	93.2	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2YMH1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_126989_1	570417.WP0513	4.97e-165	462.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Dsba oxidoreductase	dsbA	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
k59_38147_1	1123059.KB823012_gene2435	1.25e-09	64.3	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTFY@28211|Alphaproteobacteria,4415P@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_27308_1	1236908.wNo_00330	2.81e-220	615.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,47ET6@766|Rickettsiales	766|Rickettsiales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_57886_1	570417.WP0734	3.73e-124	362.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,47EXV@766|Rickettsiales	766|Rickettsiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_235251_2	330214.NIDE2797	3.06e-44	152.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889,ko:K19296	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_38157_1	1454004.AW11_03085	2.91e-105	325.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_147030_1	1236908.wNo_01930	1.89e-124	356.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,47FAB@766|Rickettsiales	766|Rickettsiales	S	protein conserved in bacteria	-	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
k59_147030_2	1236908.wNo_01940	1.03e-33	127.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,47F27@766|Rickettsiales	766|Rickettsiales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_126996_1	7668.SPU_000194-tr	0.000237	48.5	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria	33208|Metazoa	G	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve,zf-H2C2
k59_177208_1	638302.HMPREF0908_0211	7.32e-65	210.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,4H35G@909932|Negativicutes	909932|Negativicutes	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
k59_256875_1	1444711.CCJF01000005_gene1653	3.69e-20	94.4	COG3447@1|root,COG4191@1|root,COG3447@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE2,HATPase_c,HisKA,Hpt,MASE1,PAS,PAS_4,PAS_9,Response_reg
k59_305316_1	1236908.wNo_08580	3.77e-130	385.0	2DRPA@1|root,33CGB@2|Bacteria,1NNBE@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_38166_1	7159.AAEL017378-PA	3.27e-58	207.0	COG0050@1|root,KOG0460@2759|Eukaryota,38BHM@33154|Opisthokonta,3BE5J@33208|Metazoa,3CUKG@33213|Bilateria,41VN7@6656|Arthropoda,3SFX6@50557|Insecta,4526Y@7147|Diptera,45GUA@7148|Nematocera	33208|Metazoa	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	TUFM	GO:0000278,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006996,GO:0007030,GO:0007049,GO:0008135,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009059,GO:0009295,GO:0009636,GO:0009987,GO:0010033,GO:0010256,GO:0010467,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0034641,GO:0034645,GO:0042221,GO:0042493,GO:0042645,GO:0043043,GO:0043170,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0046677,GO:0050896,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:0097305,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901700	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_245302_1	7159.AAEL017990-PA	1.59e-77	243.0	2D5GH@1|root,2SYGV@2759|Eukaryota,3ASKA@33154|Opisthokonta,3C478@33208|Metazoa,3DJV7@33213|Bilateria,423NM@6656|Arthropoda,3SXI7@50557|Insecta,459TE@7147|Diptera,45KYV@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-CCHC
k59_315998_1	1150626.PHAMO_380065	7.72e-66	226.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,2JRE2@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
k59_88323_2	1229909.NSED_05340	3.93e-29	107.0	arCOG10567@1|root,arCOG10567@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_127011_1	471223.GWCH70_3127	5.77e-21	93.2	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,1WFXH@129337|Geobacillus	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_48262_1	1207063.P24_00980	3.19e-44	151.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2TVRQ@28211|Alphaproteobacteria,2JZA2@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
k59_48262_2	1231391.AMZF01000027_gene370	7.28e-12	65.9	COG0410@1|root,COG0410@2|Bacteria,1MUFR@1224|Proteobacteria,2VM45@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k59_277186_1	247490.KSU1_C1309	2.31e-30	122.0	COG5421@1|root,COG5421@2|Bacteria,2J33B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_187774_1	1133850.SHJG_1588	2.32e-27	108.0	28IJ3@1|root,2Z8K2@2|Bacteria,2H0MB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_187774_2	66377.JOBH01000004_gene3918	8.12e-38	134.0	28K2Y@1|root,2Z9S8@2|Bacteria,2I94F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_156430_1	1236908.wNo_03930	9.22e-92	279.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	ank	-	3.5.1.2	ko:K01425,ko:K06867	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Ank_2,Ank_3,Ank_4,PIN_4,PRANC
k59_17303_1	6334.EFV50733	3.56e-44	169.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria	33208|Metazoa	J	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_286030_1	7425.NV30855-PA	5.57e-13	74.7	2D0P4@1|root,2SEVG@2759|Eukaryota,38ZFV@33154|Opisthokonta,3BWC6@33208|Metazoa,3DR64@33213|Bilateria,427BH@6656|Arthropoda,3SX5N@50557|Insecta,46MRB@7399|Hymenoptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_235288_1	1229909.NSED_09625	2.23e-28	110.0	arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
k59_235288_2	436308.Nmar_1798	2.02e-14	66.6	arCOG00818@1|root,arCOG00818@2157|Archaea	2157|Archaea	S	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_316020_1	1229909.NSED_09490	6.39e-88	273.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k59_177255_1	269482.Bcep1808_3068	9.93e-72	226.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,1K0VT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
k59_27353_1	570417.WP0751	2.85e-131	377.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,47EZ6@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k59_297031_1	7029.ACYPI48436-PA	1.5e-08	60.5	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_57923_1	1236908.wNo_04840	2.55e-197	552.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,47F2H@766|Rickettsiales	766|Rickettsiales	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_57923_2	570417.WP0825	1.47e-93	274.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,47FNC@766|Rickettsiales	766|Rickettsiales	S	Belongs to the HesB IscA family	iscA1	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
k59_57923_3	570417.WP0824	3.48e-30	112.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,47FA2@766|Rickettsiales	766|Rickettsiales	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k59_305338_1	7425.NV18588-PA	5.69e-29	122.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_68374_1	7176.CPIJ006540-PA	1.06e-96	317.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_75665_1	1236908.wNo_03380	1.04e-35	133.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,47EUI@766|Rickettsiales	766|Rickettsiales	E	COG0006 Xaa-Pro aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_7968_1	7159.AAEL017291-PA	1.31e-11	70.9	28N19@1|root,2TE25@2759|Eukaryota,398IR@33154|Opisthokonta,3CCSH@33208|Metazoa,3DU34@33213|Bilateria,42BKB@6656|Arthropoda,3SUVB@50557|Insecta,45664@7147|Diptera,45CBR@7148|Nematocera	33208|Metazoa	O	Lipase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase
k59_236217_1	1121035.AUCH01000004_gene308	3.26e-114	348.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KVCK@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_189121_1	27923.ML030417a-PA	2.62e-21	100.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_317260_1	1131266.ARWQ01000002_gene475	9.29e-32	118.0	COG0159@1|root,arCOG01086@2157|Archaea,41SG0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
k59_317260_2	436308.Nmar_0919	4e-52	177.0	COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_75091_1	232721.Ajs_2200	2.76e-61	200.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VKAK@28216|Betaproteobacteria,4AJKJ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3
k59_137529_1	1236908.wNo_06320	3.86e-252	696.0	COG3898@1|root,COG3898@2|Bacteria	2|Bacteria	D	HemY domain protein	-	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	DUF4347,HemY_N,TPR_16
k59_206214_1	570417.WP0092	1.86e-194	541.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,47F59@766|Rickettsiales	766|Rickettsiales	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k59_315284_1	396588.Tgr7_1444	3.01e-67	229.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_176498_2	1236908.wNo_09610	1.6e-28	113.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,47EW9@766|Rickettsiales	766|Rickettsiales	D	Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity)	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_146435_1	570417.WP1276	1.45e-101	319.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,47EXC@766|Rickettsiales	766|Rickettsiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_167416_1	1254432.SCE1572_31550	1.33e-38	144.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_26668_1	13037.EHJ73416	1.15e-41	174.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,41V5R@6656|Arthropoda,3SINZ@50557|Insecta	33208|Metazoa	S	RNase H	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_75101_1	1041146.ATZB01000061_gene3108	9.93e-101	298.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,4BB9C@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_105550_2	1163617.SCD_n02942	1.52e-56	184.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
k59_47529_1	570417.WP0679	4.74e-36	126.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,47FFC@766|Rickettsiales	766|Rickettsiales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k59_47529_2	1236908.wNo_02320	3.24e-37	149.0	COG1357@1|root,COG1357@2|Bacteria,1RB3M@1224|Proteobacteria,2VF0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
k59_67679_1	338969.Rfer_2160	1.31e-101	322.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
k59_97826_1	1229909.NSED_09015	5.84e-100	311.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_67685_1	7668.SPU_004620-tr	1.44e-07	60.1	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_116178_1	395494.Galf_1727	2.55e-20	89.7	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,44W5Q@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	PFAM type II secretion system protein E	pilT2	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_116178_2	1384056.N787_10225	1.14e-36	131.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1X35P@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
k59_37503_1	7029.ACYPI20081-PA	8.81e-33	133.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,42AP4@6656|Arthropoda	33208|Metazoa	L	It is involved in the biological process described with proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_87584_1	570417.WP0466	7.36e-164	474.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,47EZY@766|Rickettsiales	766|Rickettsiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_97840_1	1123487.KB892846_gene699	7.76e-62	191.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,2KWGN@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_187048_1	365659.smi_1531	4.53e-06	52.4	COG0810@1|root,COG2931@1|root,COG3209@1|root,COG3266@1|root,COG5164@1|root,COG0810@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3266@2|Bacteria,COG5164@2|Bacteria,1UVAQ@1239|Firmicutes,4I2AV@91061|Bacilli,2TPXZ@28037|Streptococcus mitis	91061|Bacilli	M	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,YSIRK_signal
k59_216514_2	1163617.SCD_n00932	1.36e-31	119.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_256256_1	1041159.AZUW01000001_gene3267	1.05e-35	136.0	COG0616@1|root,COG0616@2|Bacteria,1P6WP@1224|Proteobacteria,2UYBG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	signal peptide processing	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_296370_1	1131266.ARWQ01000005_gene821	4.72e-74	231.0	COG0113@1|root,arCOG04300@2157|Archaea,41SET@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_296370_2	1229909.NSED_02550	1.67e-19	80.9	arCOG08763@1|root,arCOG08763@2157|Archaea,41SWC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_155807_1	1131266.ARWQ01000001_gene1087	5.06e-46	161.0	COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	adenylosuccinate lyase	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
k59_155807_2	1229909.NSED_08025	5.2e-27	105.0	COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
k59_87606_1	936455.KI421499_gene8053	2.29e-32	130.0	COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	MA20_09880	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1,TPR_4
k59_276571_1	1236908.wNo_05270	3.31e-105	304.0	COG1495@1|root,COG1495@2|Bacteria,1Q429@1224|Proteobacteria,2VAE2@28211|Alphaproteobacteria,47FRB@766|Rickettsiales	766|Rickettsiales	C	Disulfide bond formation protein, DsbB	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
k59_276571_2	1236908.wNo_05260	8.35e-154	442.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,47F0Y@766|Rickettsiales	766|Rickettsiales	C	Dehydrogenase	lpdA-1	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
k59_285519_1	356851.JOAN01000003_gene1451	1.85e-53	182.0	COG4695@1|root,COG4695@2|Bacteria,2GZFX@201174|Actinobacteria	201174|Actinobacteria	S	Phage portal protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_315355_1	1229909.NSED_09250	8.21e-27	101.0	arCOG08776@1|root,arCOG08776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_315355_2	436308.Nmar_1739	6.85e-35	120.0	arCOG08769@1|root,arCOG08769@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_276576_1	436308.Nmar_1301	1.69e-40	140.0	COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Domain of unknown function DUF120	-	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase
k59_276576_2	436308.Nmar_1302	2.17e-24	100.0	COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
k59_196684_1	985665.HPL003_02340	8.71e-40	145.0	28JEU@1|root,2Z98W@2|Bacteria,1VRU4@1239|Firmicutes,4HTWS@91061|Bacilli,26VIY@186822|Paenibacillaceae	91061|Bacilli	S	PFAM MULE transposase, conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_87619_1	570417.WP0466	7.13e-132	391.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,47EZY@766|Rickettsiales	766|Rickettsiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_244812_1	469617.FUAG_01808	1.59e-05	49.7	COG1396@1|root,COG4101@1|root,COG1396@2|Bacteria,COG4101@2|Bacteria,379Z2@32066|Fusobacteria	32066|Fusobacteria	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
k59_176576_1	570417.WP0795	4.27e-274	759.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,47F48@766|Rickettsiales	766|Rickettsiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_304902_2	570417.WP1213	1.31e-148	419.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,47FAX@766|Rickettsiales	766|Rickettsiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_304902_3	1236908.wNo_08660	4.37e-48	159.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,47ET9@766|Rickettsiales	766|Rickettsiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_266757_1	1236908.wNo_04600	2.42e-143	411.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,47F3C@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	trmU	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
k59_276590_2	1131266.ARWQ01000009_gene958	5e-58	187.0	COG0368@1|root,arCOG04338@2157|Archaea,41SI6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
k59_116219_1	1236908.wNo_02350	1.44e-134	387.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2TR6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	futA1	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
k59_116219_2	570417.WP0676	7.33e-94	280.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,47G4A@766|Rickettsiales	766|Rickettsiales	F	nucleobase biosynthetic process	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_57252_2	713587.THITH_03240	1.87e-47	163.0	COG2358@1|root,COG2358@2|Bacteria,1NRSC@1224|Proteobacteria	1224|Proteobacteria	S	TRAP transporter, solute receptor (TAXI family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
k59_207398_1	7425.NV30710-PA	8.63e-75	244.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_88955_1	1280954.HPO_15478	3.48e-15	87.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43ZJT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Peptidase_M10_C
k59_156937_1	7029.ACYPI20262-PA	2.46e-34	136.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_99305_1	69319.XP_008555671.1	1.5e-24	108.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AKET@33154|Opisthokonta,3C632@33208|Metazoa,3DM50@33213|Bilateria,42913@6656|Arthropoda,3T184@50557|Insecta,46MB3@7399|Hymenoptera	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_257520_1	1236908.wNo_08460	1.48e-10	58.2	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,47FBW@766|Rickettsiales	766|Rickettsiales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
k59_257520_2	570417.WP1189	1.02e-165	468.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,47F1V@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
k59_268272_1	396588.Tgr7_0189	4.9e-59	191.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
k59_168850_2	10689.H9C0A7_BPCPT	2.23e-29	122.0	4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses  no RNA stage,4QPWY@28883|Caudovirales,4QJW9@10662|Myoviridae	10662|Myoviridae	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_245826_2	330214.NIDE3451	1.49e-40	142.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k59_27937_1	1236908.wNo_02740	1.31e-103	322.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,47EV7@766|Rickettsiales	766|Rickettsiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_139025_1	706587.Desti_1075	6.46e-66	225.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_127620_1	330214.NIDE0903	1.39e-10	60.5	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_127620_2	330214.NIDE0902	5.29e-65	202.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	soxD	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
k59_68930_1	1173024.KI912152_gene364	1.14e-130	384.0	COG3119@1|root,COG3119@2|Bacteria,1G3EC@1117|Cyanobacteria,1JJCF@1189|Stigonemataceae	1117|Cyanobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
k59_139045_1	570417.WP0933	2.81e-72	222.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,47F52@766|Rickettsiales	766|Rickettsiales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_139045_2	570417.WP0932	9.27e-56	182.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,47F00@766|Rickettsiales	766|Rickettsiales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
k59_128179_1	7668.SPU_013462-tr	1.08e-07	57.8	COG0666@1|root,KOG0504@2759|Eukaryota	2759|Eukaryota	I	protein ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	Death,zf-C3HC4_3
k59_89601_1	715451.ambt_17670	1.61e-64	211.0	COG3385@1|root,COG3385@2|Bacteria,1QT8J@1224|Proteobacteria,1RY7W@1236|Gammaproteobacteria,469NT@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_246353_1	1485544.JQKP01000013_gene1849	5.42e-68	210.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VRCR@28216|Betaproteobacteria,44WEK@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Bacterial protein of unknown function (DUF899)	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
k59_207957_1	228410.NE0229	1e-87	280.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_278411_1	1283300.ATXB01000001_gene1053	1.13e-66	223.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1XEIC@135618|Methylococcales	135618|Methylococcales	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
k59_306095_1	135651.CBN15281	5.65e-21	98.2	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3C0WJ@33208|Metazoa,3E5AA@33213|Bilateria,40RE5@6231|Nematoda,1M8IG@119089|Chromadorea,40WYR@6236|Rhabditida	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17
k59_89639_1	1298867.AUES01000001_gene1795	5.93e-38	138.0	28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2TSKX@28211|Alphaproteobacteria,3JT6R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_69543_1	1163617.SCD_n02127	6.09e-47	171.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_118016_1	314278.NB231_01833	6.64e-109	351.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_298289_1	27923.ML046335a-PA	1.92e-23	108.0	COG0480@1|root,KOG1075@1|root,KOG0467@2759|Eukaryota,KOG1075@2759|Eukaryota,38B8Q@33154|Opisthokonta,3BEBA@33208|Metazoa	33208|Metazoa	J	elongation factor Tu	EFTUD1	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019637,GO:0019693,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042256,GO:0042278,GO:0043021,GO:0043022,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044877,GO:0046039,GO:0046128,GO:0046483,GO:0055086,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	-	ko:K14536	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
k59_128234_1	1131266.ARWQ01000004_gene1492	9.57e-113	339.0	COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_287031_1	330779.Saci_1109	8.89e-09	58.9	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
k59_287031_2	1429916.X566_04270	2.62e-21	92.4	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,3JRVC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
k59_128236_1	1236908.wNo_04580	1.37e-116	345.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,47F03@766|Rickettsiales	766|Rickettsiales	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
k59_69564_2	342610.Patl_1431	1.87e-19	90.1	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria,2Q0QB@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	vgb	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	SGL
k59_128238_2	1121035.AUCH01000004_gene336	1.01e-09	57.8	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2VWEF@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Belongs to the anti-sigma-factor antagonist family	btrV	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
k59_28610_1	1175306.GWL_31790	1.03e-29	119.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,2VV1X@28216|Betaproteobacteria,4737R@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
k59_317235_1	1229909.NSED_01420	8.17e-08	52.8	COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
k59_317235_2	436308.Nmar_0293	2.02e-31	111.0	COG5625@1|root,arCOG04189@2157|Archaea,41T7F@651137|Thaumarchaeota	651137|Thaumarchaeota	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_317235_3	436308.Nmar_0292	1.42e-53	171.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
k59_298301_1	436308.Nmar_0993	3.05e-42	143.0	arCOG03937@1|root,arCOG03937@2157|Archaea,41SWM@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG2002 Regulators of stationary sporulation gene expression	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_298301_2	1229909.NSED_05720	5.8e-65	201.0	arCOG08754@1|root,arCOG08754@2157|Archaea,41SUV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_198714_1	2340.JV46_23210	2.47e-41	142.0	COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_49518_1	570417.WP0854	2.28e-138	390.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,47FCH@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_49518_2	1030157.AFMP01000044_gene1763	2.08e-07	51.6	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,2K17I@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
k59_128247_1	400682.PAC_15723685	5.46e-39	148.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_79518_1	330214.NIDE3963	7.51e-40	147.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
k59_79527_1	6183.Smp_182910.1	7.05e-38	145.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria	33208|Metazoa	L	retrotransposable element Tf2 155 kDa protein type 1-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_79556_1	7260.FBpp0254607	1.2e-32	130.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_238770_1	8479.XP_008161408.1	1.16e-118	367.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,48AQP@7711|Chordata,48YUZ@7742|Vertebrata,4CJ7F@8459|Testudines	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_308578_1	6238.CBG25708	4.17e-218	681.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,411FR@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,gag-asp_proteas,rve
k59_238820_1	196367.JNFG01000209_gene256	1.11e-68	225.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4277
k59_308625_1	7370.XP_005182599.1	1.06e-34	131.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,4556V@7147|Diptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_238883_1	1410620.SHLA_47c000110	1.16e-28	115.0	2CDQ7@1|root,2Z7KV@2|Bacteria,1MY2D@1224|Proteobacteria,2TR92@28211|Alphaproteobacteria,4B7AM@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308658_1	436308.Nmar_1727	4.56e-90	284.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	651137|Thaumarchaeota	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
k59_308658_2	420247.Msm_1037	3.55e-15	73.9	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23NYV@183925|Methanobacteria	183925|Methanobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
k59_308661_1	436308.Nmar_0045	7.1e-55	175.0	arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308661_2	1131266.ARWQ01000001_gene1322	1e-35	125.0	arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308661_3	436308.Nmar_0047	5.37e-06	48.1	COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_238995_1	1122201.AUAZ01000019_gene1807	3.68e-47	168.0	COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,1RYVX@1236|Gammaproteobacteria,466E3@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Haemolysin secretion/activation protein ShlB/FhaC/HecB	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
k59_239005_1	7029.ACYPI20081-PA	1.41e-54	197.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,42AP4@6656|Arthropoda	33208|Metazoa	L	It is involved in the biological process described with proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_239017_1	163164.WD_0663	2.18e-11	60.8	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,47FGQ@766|Rickettsiales	766|Rickettsiales	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
k59_239017_2	570417.WP1185	1.39e-144	417.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,47EWF@766|Rickettsiales	766|Rickettsiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_239074_1	935557.ATYB01000009_gene734	4.16e-69	239.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9
k59_308911_1	1229909.NSED_08500	5.07e-67	231.0	arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_239130_1	436308.Nmar_1727	6.14e-88	277.0	COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota	651137|Thaumarchaeota	S	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
k59_239143_1	570417.WP0815	1.53e-43	144.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,47FEH@766|Rickettsiales	766|Rickettsiales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_239143_2	570417.WP0816	1.15e-148	422.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2URBC@28211|Alphaproteobacteria,47G6K@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_309013_1	1424334.W822_02440	1.14e-43	155.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2W925@28216|Betaproteobacteria,3T6IU@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_309044_1	436308.Nmar_1007	4.06e-184	522.0	COG1253@1|root,arCOG00626@2157|Archaea	2157|Archaea	S	COG1253 Hemolysins and related proteins containing CBS domains	cbs9	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
k59_239323_1	436308.Nmar_0999	2.18e-27	114.0	arCOG10350@1|root,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_210953_1	891968.Anamo_1189	2.66e-17	89.7	COG5421@1|root,COG5421@2|Bacteria,3TAD9@508458|Synergistetes	508458|Synergistetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_191142_1	1236908.wNo_03260	1.45e-248	692.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,47F2Q@766|Rickettsiales	766|Rickettsiales	L	Single-stranded-DNA-specific exonuclease (RecJ)	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
k59_91579_1	7260.FBpp0249759	1.97e-27	110.0	KOG4330@1|root,KOG4330@2759|Eukaryota	2759|Eukaryota	S	positive regulation of interleukin-6 production	AKIRIN2	GO:0000122,GO:0001817,GO:0001819,GO:0002237,GO:0003674,GO:0003712,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0008150,GO:0008284,GO:0009605,GO:0009607,GO:0009617,GO:0009790,GO:0009792,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010033,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010950,GO:0010952,GO:0012505,GO:0016020,GO:0017053,GO:0019219,GO:0019222,GO:0019899,GO:0030162,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031965,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032268,GO:0032270,GO:0032496,GO:0032501,GO:0032502,GO:0032675,GO:0032755,GO:0032991,GO:0033993,GO:0042127,GO:0042221,GO:0043085,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045862,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048856,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051336,GO:0051345,GO:0051704,GO:0051707,GO:0052547,GO:0052548,GO:0060255,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0140110,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K06752	ko04145,ko04514,ko04612,ko04640,ko04658,ko04659,ko04672,ko04940,ko05140,ko05145,ko05150,ko05152,ko05164,ko05166,ko05168,ko05310,ko05320,ko05321,ko05322,ko05323,ko05330,ko05332,ko05416,map04145,map04514,map04612,map04640,map04658,map04659,map04672,map04940,map05140,map05145,map05150,map05152,map05164,map05166,map05168,map05310,map05320,map05321,map05322,map05323,map05330,map05332,map05416	-	-	-	ko00000,ko00001,ko04147,ko04516	-	-	-	-
k59_220915_1	1459636.NTE_02340	2.93e-12	72.4	COG0840@1|root,arCOG02344@2157|Archaea	2157|Archaea	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
k59_81593_1	1235457.C404_11715	4.04e-07	52.8	COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2VJ7W@28216|Betaproteobacteria,1K7ZH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	5.3.3.7	ko:K22003	ko00660,map00660	-	R02244	RC00668	ko00000,ko00001,ko01000	-	-	-	SBP_bac_11
k59_81593_2	1366050.N234_29400	4.53e-27	107.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VNWD@28216|Betaproteobacteria,1K3YD@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_181185_1	1288494.EBAPG3_2870	2.73e-41	144.0	28IJP@1|root,2Z8KI@2|Bacteria,1R9DP@1224|Proteobacteria,2VVJ7@28216|Betaproteobacteria,3735I@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_101116_1	296591.Bpro_4835	1.31e-53	175.0	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2VVUF@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
k59_121334_1	570417.WP0988	2.16e-64	200.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,47FG4@766|Rickettsiales	766|Rickettsiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
k59_121334_3	1236908.wNo_06850	4.92e-58	182.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,47FI1@766|Rickettsiales	766|Rickettsiales	C	Cytochrome C	cycM	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
k59_91595_1	1348657.M622_04885	5.05e-63	209.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k59_300536_1	570417.WP0229	1.38e-131	390.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,47EWH@766|Rickettsiales	766|Rickettsiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_220925_2	266779.Meso_0068	1.48e-17	80.5	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,43JSE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
k59_180394_1	1236908.wNo_03910	4.01e-47	152.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,2TT35@28211|Alphaproteobacteria,47GI3@766|Rickettsiales	766|Rickettsiales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
k59_180394_2	1236908.wNo_03900	1.87e-55	176.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,47F9H@766|Rickettsiales	766|Rickettsiales	O	COG0694 Thioredoxin-like proteins and domains	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
k59_40790_2	396588.Tgr7_1464	4.47e-50	173.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_170527_1	7070.TC015470-PA	1.06e-22	103.0	COG2801@1|root,KOG1922@1|root,KOG0017@2759|Eukaryota,KOG1922@2759|Eukaryota,38C7D@33154|Opisthokonta,3BDNK@33208|Metazoa,3CX9J@33213|Bilateria,41VES@6656|Arthropoda,3SHX8@50557|Insecta	33208|Metazoa	TZ	Actin binding. It is involved in the biological process described with cellular component organization	FHDC1	GO:0001763,GO:0002009,GO:0002064,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005884,GO:0007275,GO:0007424,GO:0008092,GO:0008150,GO:0009653,GO:0009888,GO:0009987,GO:0015629,GO:0030154,GO:0030855,GO:0031110,GO:0031113,GO:0031941,GO:0032092,GO:0032271,GO:0032501,GO:0032502,GO:0032886,GO:0032991,GO:0033043,GO:0035146,GO:0035147,GO:0035150,GO:0035239,GO:0035295,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043393,GO:0044087,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0048468,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051128,GO:0051493,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061138,GO:0065007,GO:0065008,GO:0065009,GO:0070507,GO:0090066,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:1902903,GO:1904529,GO:1904531,GO:1904616,GO:1904618	-	-	-	-	-	-	-	-	-	-	Drf_FH3,FH2
k59_290147_1	225937.HP15_3690	8.63e-29	119.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,465DI@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_160631_1	1342299.Z947_120	8.7e-76	243.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_250157_1	7029.ACYPI52857-PA	1.62e-77	270.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_40800_1	1229909.NSED_00230	1.13e-11	61.6	arCOG10515@1|root,arCOG10515@2157|Archaea,41TAP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_40800_2	95619.PM1_0218155	4.74e-20	84.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Acylphosphatase
k59_40800_3	436308.Nmar_0102	6.59e-07	49.7	COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_130684_1	3641.EOX94158	9.54e-14	75.9	COG2801@1|root,KOG0017@2759|Eukaryota,37SNQ@33090|Viridiplantae,3GHRQ@35493|Streptophyta	35493|Streptophyta	L	spliceosomal complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,gag_pre-integrs,rve,zf-CCHC
k59_180412_1	570417.WP1072	3.07e-103	309.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,47EU5@766|Rickettsiales	766|Rickettsiales	M	Lipoprotein releasing system transmembrane protein	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
k59_840_1	381666.H16_B0692	5.52e-09	63.5	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	TIGRFAM outer membrane adhesin like proteiin	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VWA_2
k59_50770_1	1156937.MFUM_960011	1.6e-33	125.0	COG0123@1|root,COG0123@2|Bacteria,46SMT@74201|Verrucomicrobia,37GFQ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
k59_50770_2	392499.Swit_0003	2.14e-06	51.6	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2K1PS@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k59_220272_1	1236908.wNo_06580	6.64e-224	629.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,47F1D@766|Rickettsiales	766|Rickettsiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
k59_180433_1	570417.WP0355	4.67e-141	424.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,47EVZ@766|Rickettsiales	766|Rickettsiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_110693_1	1240349.ANGC01000005_gene1568	4.74e-20	92.4	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4FUJH@85025|Nocardiaceae	201174|Actinobacteria	V	ABC transporter ATP-binding	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_20833_1	1158292.JPOE01000002_gene3281	9.77e-252	717.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1KIWA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_260275_1	926692.AZYG01000085_gene856	1.54e-79	253.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales	186801|Clostridia	L	Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_260275_2	1236908.wNo_11270	4.88e-46	149.0	COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2U9CF@28211|Alphaproteobacteria,47GI1@766|Rickettsiales	766|Rickettsiales	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_90810_1	179408.Osc7112_1147	2.66e-51	178.0	COG3335@1|root,COG3335@2|Bacteria,1G4FA@1117|Cyanobacteria,1HBRR@1150|Oscillatoriales	1117|Cyanobacteria	L	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
k59_858_1	7425.NV22976-PA	2.38e-36	144.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_40852_1	7159.AAEL005015-PA	6.46e-123	384.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VPS@33154|Opisthokonta,3C5ZM@33208|Metazoa,3DM1B@33213|Bilateria,42CJJ@6656|Arthropoda,3STFX@50557|Insecta,4582J@7147|Diptera,45M6U@7148|Nematocera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_130728_1	1131266.ARWQ01000002_gene661	3.84e-60	191.0	COG1430@1|root,arCOG03116@2157|Archaea,41SP3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
k59_130728_2	1131266.ARWQ01000002_gene662	5.96e-24	93.6	arCOG08740@1|root,arCOG08740@2157|Archaea,41T52@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_60767_1	1266925.JHVX01000006_gene2095	5.69e-33	115.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,373DE@32003|Nitrosomonadales	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
k59_60767_2	1288494.EBAPG3_23300	9.51e-209	591.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_863_1	582899.Hden_0689	1.34e-47	159.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,2U2FE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_863_2	582899.Hden_0690	1.45e-23	99.0	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_110703_1	1459636.NTE_00853	1.07e-77	254.0	COG0531@1|root,arCOG00451@1|root,arCOG00009@2157|Archaea,arCOG00451@2157|Archaea,41SYK@651137|Thaumarchaeota	651137|Thaumarchaeota	ET	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
k59_50795_1	323848.Nmul_A1202	1.67e-12	64.3	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,3737J@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	ratA	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
k59_50795_2	228410.NE0430	5.5e-76	229.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,37321@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
k59_50795_3	305700.B447_03733	1.98e-20	85.1	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria,2KW6P@206389|Rhodocyclales	206389|Rhodocyclales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
k59_180447_1	1131553.JIBI01000002_gene1793	1.14e-91	275.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,372B3@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Transporter associated domain	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
k59_220289_1	7029.ACYPI39717-PA	2.8e-38	149.0	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI39717-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_310043_1	316057.RPD_2022	5.37e-80	245.0	COG0179@1|root,COG0179@2|Bacteria,1QUQP@1224|Proteobacteria,2TWGE@28211|Alphaproteobacteria,3JR43@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Domain of unknown function (DUF2437)	MA20_15150	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
k59_260295_1	1121324.CLIT_4c00330	1.55e-35	135.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,25TBN@186804|Peptostreptococcaceae	186801|Clostridia	S	NMT1-like family	bcsP	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_20863_1	7091.BGIBMGA008441-TA	1.84e-09	63.9	COG2801@1|root,KOG0017@2759|Eukaryota,38VN8@33154|Opisthokonta,3BZS8@33208|Metazoa,3E3IW@33213|Bilateria,42305@6656|Arthropoda,3SRNX@50557|Insecta,44AI0@7088|Lepidoptera	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_130746_1	160488.PP_0880	1.35e-19	89.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,1RN08@1236|Gammaproteobacteria,1YX2F@136845|Pseudomonas putida group	1236|Gammaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	dppC	-	-	ko:K12370	ko02010,map02010	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
k59_130746_2	1121439.dsat_0022	9.06e-17	79.7	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WNZ8@28221|Deltaproteobacteria,2M8SS@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K15585	ko02010,ko02024,map02010,map02024	M00239,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_230264_1	163164.WD_1041	1.09e-99	318.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	AXH,NADase_NGA
k59_30897_1	324925.Ppha_0340	8.48e-34	140.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_260305_1	1229909.NSED_02755	9.12e-37	127.0	COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
k59_260305_2	1131266.ARWQ01000005_gene854	9.28e-27	105.0	COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
k59_70522_1	1380763.BG53_00880	1.11e-31	124.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,4H9TQ@91061|Bacilli,26RR6@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
k59_40874_1	1288494.EBAPG3_7740	9.01e-139	400.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,372UH@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_100574_1	6183.Smp_195110.1	4.78e-15	82.4	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_220300_1	7260.FBpp0254607	2.17e-41	159.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_250241_1	164328.Phyra86833	5.46e-25	104.0	COG2801@1|root,KOG0017@2759|Eukaryota,3QHRV@4776|Peronosporales	4776|Peronosporales	L	gag-polypeptide of LTR copia-type	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2
k59_300033_1	1131266.ARWQ01000005_gene821	1.55e-88	270.0	COG0113@1|root,arCOG04300@2157|Archaea,41SET@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_70529_1	1485544.JQKP01000010_gene815	1.06e-49	173.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,44VEU@713636|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_20883_1	436308.Nmar_1412	1.23e-79	238.0	COG1601@1|root,arCOG01640@2157|Archaea,41STZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Translation initiation factor	-	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
k59_20883_2	1229909.NSED_07750	8.09e-22	87.4	COG2412@1|root,arCOG04051@2157|Archaea,41SS6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
k59_70530_1	338969.Rfer_2852	6.54e-81	253.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	cytC6	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EB_dh
k59_100577_1	446468.Ndas_2503	4.34e-110	338.0	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,4EI7P@85012|Streptosporangiales	201174|Actinobacteria	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_20884_2	570417.WP0505	4.35e-78	234.0	COG1863@1|root,COG1863@2|Bacteria,1PDJ3@1224|Proteobacteria,2UDVY@28211|Alphaproteobacteria,47FT1@766|Rickettsiales	766|Rickettsiales	P	Na H antiporter	mnhE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
k59_160742_1	330214.NIDE0324	1.84e-113	339.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
k59_310077_1	748247.AZKH_p0041	7.26e-102	301.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_140606_1	1236908.wNo_03480	4.77e-59	190.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U9SX@28211|Alphaproteobacteria,47FCZ@766|Rickettsiales	766|Rickettsiales	V	proteins, homologs of microcin C7 resistance protein MccF	mccF	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_140606_2	1236908.wNo_03490	3.44e-36	133.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4
k59_180504_1	1038858.AXBA01000018_gene1212	2.46e-17	82.0	COG2227@1|root,COG2227@2|Bacteria,1QU62@1224|Proteobacteria,2TW17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
k59_180504_2	153496.JNAB01000002_gene1456	9.25e-78	247.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2TR8G@28211|Alphaproteobacteria,2JPDD@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
k59_10939_2	1229909.NSED_07790	1.08e-77	237.0	arCOG08773@1|root,arCOG08773@2157|Archaea,41SNY@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_210424_1	570417.WP0760	1.65e-132	385.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,47EX5@766|Rickettsiales	766|Rickettsiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
k59_80955_1	243233.MCA1511	2.43e-33	130.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,1S4C5@1236|Gammaproteobacteria,1XGYR@135618|Methylococcales	1236|Gammaproteobacteria	M	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF29,Glyco_transf_9,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k59_20901_1	7029.ACYPI009216-PA	1.95e-89	306.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_930_1	7029.ACYPI42490-PA	8.42e-25	106.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EBZ8@33342|Paraneoptera	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_220346_1	1121448.DGI_3261	1.23e-23	94.7	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42R6H@68525|delta/epsilon subdivisions,2X5NF@28221|Deltaproteobacteria,2MGTA@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aconitase C-terminal domain	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_220346_2	1459636.NTE_01255	4e-48	164.0	COG0065@1|root,arCOG01698@2157|Archaea,41S7A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_111958_1	323848.Nmul_A1229	8.37e-15	68.9	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,373MD@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
k59_111958_2	1288494.EBAPG3_12890	6.09e-96	291.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,3723R@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_141893_1	7159.AAEL009221-PA	3.29e-16	83.6	KOG4281@1|root,KOG4281@2759|Eukaryota,38T0U@33154|Opisthokonta,3BKQC@33208|Metazoa,3CSHP@33213|Bilateria,420QQ@6656|Arthropoda,3SNV0@50557|Insecta,453K2@7147|Diptera,45HHK@7148|Nematocera	33208|Metazoa	S	PCO_ADO	ADO	GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0047800,GO:0051213,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575	1.13.11.19	ko:K10712	ko00430,ko01100,map00430,map01100	-	R02467	RC00404	ko00000,ko00001,ko01000	-	-	-	PCO_ADO
k59_42344_1	436308.Nmar_0105	8.79e-78	239.0	COG0037@1|root,arCOG00042@2157|Archaea,41S84@651137|Thaumarchaeota	651137|Thaumarchaeota	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
k59_185901_1	7029.ACYPI33688-PA	6.09e-59	211.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_56118_1	76114.ebA3857	2.19e-38	142.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,2KUQF@206389|Rhodocyclales	206389|Rhodocyclales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
k59_56118_2	582744.Msip34_2486	1.96e-13	69.3	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,2KM0B@206350|Nitrosomonadales	206350|Nitrosomonadales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
k59_96664_1	570417.WP0969	2.42e-213	593.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,47F1R@766|Rickettsiales	766|Rickettsiales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
k59_96664_2	1236908.wNo_05590	3.84e-197	547.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,47F6R@766|Rickettsiales	766|Rickettsiales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_195591_1	555778.Hneap_1019	9.67e-54	191.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k59_36345_1	436308.Nmar_1637	5.39e-08	59.3	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_46481_1	1229909.NSED_00825	1.44e-45	149.0	COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	RNase H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
k59_46481_2	1131266.ARWQ01000008_gene327	3.08e-39	144.0	COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_215547_1	1236908.wNo_04240	4.01e-69	240.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47GS5@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Peptidase_M9
k59_284667_1	570417.WP0638	4.28e-22	94.7	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47FE1@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_284667_2	570417.WP0639	1.54e-143	407.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2TRDY@28211|Alphaproteobacteria,47FDM@766|Rickettsiales	766|Rickettsiales	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	RmlD_sub_bind
k59_25807_1	243233.MCA1511	1.29e-29	122.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,1S4C5@1236|Gammaproteobacteria,1XGYR@135618|Methylococcales	1236|Gammaproteobacteria	M	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF29,Glyco_transf_9,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k59_104752_1	1236908.wNo_10810	1.79e-50	167.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,47ETT@766|Rickettsiales	766|Rickettsiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_295354_1	497964.CfE428DRAFT_2700	7e-48	163.0	COG0387@1|root,COG0387@2|Bacteria,46V3G@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sodium/calcium exchanger protein	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
k59_275514_1	632292.Calhy_2414	9.06e-59	190.0	COG0125@1|root,COG0125@2|Bacteria,1V0EA@1239|Firmicutes,24AIX@186801|Clostridia,42I1F@68295|Thermoanaerobacterales	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
k59_96700_1	1236908.wNo_03220	3.62e-71	233.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,47F2J@766|Rickettsiales	766|Rickettsiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_284678_1	1236908.wNo_08160	9.2e-88	289.0	COG1196@1|root,COG1196@2|Bacteria,1R0YX@1224|Proteobacteria	1224|Proteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_46512_1	570417.WP0476	3.31e-200	565.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,47F1F@766|Rickettsiales	766|Rickettsiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
k59_215595_1	330214.NIDE0277	1.28e-84	271.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
k59_96720_1	224911.27355296	4.74e-06	47.8	COG2197@1|root,COG2197@2|Bacteria,1R837@1224|Proteobacteria,2U4AS@28211|Alphaproteobacteria,3JWYB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_96720_2	1123508.JH636445_gene6656	9.43e-17	78.6	COG1917@1|root,COG1917@2|Bacteria,2J31X@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4437
k59_225396_1	570417.WP0643	7.46e-115	347.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,47F1A@766|Rickettsiales	766|Rickettsiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_36397_1	7425.NV21123-PA	4.89e-36	143.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria,42261@6656|Arthropoda,3SQT9@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_215613_1	7029.ACYPI50906-PA	4.07e-19	90.1	2EABX@1|root,2SGK9@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RNase_H
k59_166363_1	1459636.NTE_00800	3.39e-126	379.0	COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_66642_1	330214.NIDE0483	2.24e-88	270.0	COG4992@1|root,COG4992@2|Bacteria,3J0AB@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k59_5450_1	289376.THEYE_A0761	2.03e-40	144.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE,Usp
k59_5450_2	289376.THEYE_A0760	5.81e-13	65.9	2EGXE@1|root,33APK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_175676_1	472759.Nhal_1782	2.07e-64	218.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1WXW1@135613|Chromatiales	135613|Chromatiales	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
k59_136513_1	570417.WP1381	4.78e-99	293.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,47FA7@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179,ko:K06125	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117,M00128	R05000,R05615,R05616,R07273	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_295416_1	257310.BB1925	4.16e-123	362.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VI7S@28216|Betaproteobacteria,3T1HH@506|Alcaligenaceae	28216|Betaproteobacteria	E	Aminotransferase	alaC	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_66656_1	570417.WP1156	2.18e-167	474.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,47FYG@766|Rickettsiales	766|Rickettsiales	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_66656_2	1236908.wNo_08140	2.12e-41	147.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,47ETU@766|Rickettsiales	766|Rickettsiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_96777_1	1236908.wNo_08570	5.21e-113	348.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,47F2B@766|Rickettsiales	766|Rickettsiales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_265744_1	330214.NIDE4097	1.45e-68	224.0	COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_186044_1	1229909.NSED_01810	1.06e-87	268.0	COG1808@1|root,arCOG02264@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
k59_104799_1	436308.Nmar_1774	1.34e-28	111.0	COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
k59_104799_2	1229909.NSED_09485	1.84e-75	232.0	arCOG08811@1|root,arCOG08811@2157|Archaea,41T85@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_304242_1	1131266.ARWQ01000008_gene306	4.6e-76	241.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k59_234104_1	570417.WP0924	2.46e-218	607.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,47F3V@766|Rickettsiales	766|Rickettsiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k59_234104_2	570417.WP0923	2.13e-21	87.8	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,47FCE@766|Rickettsiales	766|Rickettsiales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
k59_36449_1	7029.ACYPI070993-PA	1.99e-24	105.0	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI070993-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_87636_1	570417.WP0219	7.64e-234	668.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,47F0W@766|Rickettsiales	766|Rickettsiales	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_37570_1	570417.WP1006	1.32e-220	621.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,47EWK@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
k59_206320_1	436308.Nmar_0067	3.7e-92	295.0	COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
k59_285547_1	1236908.wNo_03470	3.9e-109	315.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,47F9N@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
k59_285547_2	1236908.wNo_03480	4.08e-89	268.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U9SX@28211|Alphaproteobacteria,47FCZ@766|Rickettsiales	766|Rickettsiales	V	proteins, homologs of microcin C7 resistance protein MccF	mccF	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
k59_226460_1	33169.AAS52222	3.04e-07	61.2	COG1061@1|root,2QT4U@2759|Eukaryota,38GE0@33154|Opisthokonta,3NWXY@4751|Fungi,3QQHS@4890|Ascomycota,3RR67@4891|Saccharomycetes,3RYZM@4893|Saccharomycetaceae	4751|Fungi	A	Saccharomyces cerevisiae YDR332W	irc3	GO:0000002,GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0007005,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010467,GO:0010501,GO:0016043,GO:0016070,GO:0016072,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022613,GO:0031974,GO:0031981,GO:0032042,GO:0033676,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070035,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360	-	ko:K17677	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C,ResIII
k59_57270_1	6087.XP_002159887.2	2.57e-12	67.4	COG5593@1|root,KOG2038@2759|Eukaryota,38CDC@33154|Opisthokonta,3BH9K@33208|Metazoa	33208|Metazoa	JK	proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	CEBPZ	GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000982,GO:0000987,GO:0001012,GO:0001067,GO:0001077,GO:0001228,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14832	-	-	-	-	ko00000,ko03009	-	-	-	CBF
k59_116246_2	436308.Nmar_1203	6.26e-82	252.0	arCOG10580@1|root,arCOG10580@2157|Archaea	436308.Nmar_1203|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_244837_1	7213.XP_004520373.1	2.67e-48	176.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,429UH@6656|Arthropoda,3T0UB@50557|Insecta,458R2@7147|Diptera	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_126443_1	504832.OCAR_7097	4.85e-75	231.0	COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2TVF5@28211|Alphaproteobacteria,3JXK5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
k59_206331_1	375286.mma_1293	4.07e-104	316.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,476BH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k59_187114_1	1127518.H9C0Z2_9CAUD	1.7e-29	119.0	4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses  no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae	10662|Myoviridae	S	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_234859_1	163164.WD_0878	2.7e-46	153.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,47F9F@766|Rickettsiales	766|Rickettsiales	L	hmm pf01612	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
k59_234859_2	1236908.wNo_03660	2.61e-68	207.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,47FN8@766|Rickettsiales	766|Rickettsiales	O	Thioredoxin	trx	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_206334_1	1121929.KB898663_gene1102	7.8e-14	74.3	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,4HB61@91061|Bacilli,471I0@74385|Gracilibacillus	91061|Bacilli	F	N-terminal domain of ribose phosphate pyrophosphokinase	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
k59_226489_1	1236908.wNo_11050	1.18e-31	110.0	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,2UFQS@28211|Alphaproteobacteria,47FKN@766|Rickettsiales	766|Rickettsiales	S	Iron-sulphur cluster assembly	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
k59_226489_2	1236908.wNo_11040	1.33e-23	91.3	COG5389@1|root,COG5389@2|Bacteria,1N82D@1224|Proteobacteria,2UAUA@28211|Alphaproteobacteria,47FSR@766|Rickettsiales	766|Rickettsiales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
k59_216586_1	7029.ACYPI004902-PA	1.51e-59	212.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,42AN1@6656|Arthropoda	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_155886_1	90675.XP_010495765.1	3.1e-10	66.2	COG2801@1|root,KOG0017@2759|Eukaryota,37SNQ@33090|Viridiplantae,3GHRQ@35493|Streptophyta	35493|Streptophyta	L	spliceosomal complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_97926_1	330214.NIDE3313	1.41e-126	398.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_216596_1	330214.NIDE1344	1.51e-107	324.0	COG1508@1|root,COG1508@2|Bacteria,3J0AT@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k59_75198_1	1304877.KI519399_gene2906	1.4e-85	263.0	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k59_256337_1	1131266.ARWQ01000005_gene826	9.08e-114	333.0	COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
k59_51146_1	7029.ACYPI000268-PA	6.29e-33	130.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_41223_1	1120999.JONM01000006_gene2416	7.3e-72	219.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,2KQ6A@206351|Neisseriales	206351|Neisseriales	E	Psort location Cytoplasmic, score 8.96	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
k59_131116_1	748247.AZKH_2834	4.51e-65	209.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2VHYP@28216|Betaproteobacteria,2KVT3@206389|Rhodocyclales	206389|Rhodocyclales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_290548_1	570417.WP0202	1.57e-39	133.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	MA20_02250	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
k59_220639_1	1236959.BAMT01000002_gene1812	4.73e-67	228.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_31313_1	7029.ACYPI41603-PA	4.63e-35	138.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T00U@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_180843_1	1131266.ARWQ01000001_gene1300	3.52e-37	132.0	arCOG06534@1|root,arCOG10415@1|root,arCOG06534@2157|Archaea,arCOG10415@2157|Archaea,41T6I@651137|Thaumarchaeota	651137|Thaumarchaeota	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_131131_1	570417.WP0766	2.28e-279	775.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,47ET4@766|Rickettsiales	766|Rickettsiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
k59_250584_1	795666.MW7_2331	2.8e-30	108.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,1K8PA@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA2	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k59_250584_2	935848.JAEN01000009_gene1493	3.1e-22	87.8	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2PXI3@265|Paracoccus	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	cspA4	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_121017_1	1026882.MAMP_02806	5.13e-25	106.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,462YP@72273|Thiotrichales	72273|Thiotrichales	T	Sigma factor RpoE negative regulatory protein RseB	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_111071_1	436308.Nmar_0096	2.47e-150	441.0	COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
k59_310355_1	1288494.EBAPG3_6510	2.62e-62	202.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,371QK@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	rbcR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k59_61147_1	5507.FOXG_17759P0	1.04e-05	52.8	KOG1075@1|root,KOG1075@2759|Eukaryota,3A50K@33154|Opisthokonta,3P4T5@4751|Fungi,3QYV3@4890|Ascomycota,21EBC@147550|Sordariomycetes,3TKYE@5125|Hypocreales,1FUQK@110618|Nectriaceae	4751|Fungi	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_131143_1	1131266.ARWQ01000001_gene1085	3.72e-119	353.0	COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
k59_1182_5	7070.TC001491-PA	8.25e-249	754.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_100880_1	1458427.BAWN01000012_gene705	4.73e-71	235.0	COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria,2WE9S@28216|Betaproteobacteria	28216|Betaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
k59_210724_1	1042375.AFPL01000026_gene3691	3.98e-08	54.7	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,1RZJJ@1236|Gammaproteobacteria,469VB@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k59_1190_1	331869.BAL199_27671	1.42e-91	275.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria,4BRD4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
k59_111105_1	1158292.JPOE01000002_gene1642	1.65e-28	110.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,1KKDT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
k59_111105_2	323848.Nmul_A1099	2.15e-46	153.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,371MN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k59_250620_1	1288494.EBAPG3_21370	1e-70	220.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,372RB@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
k59_250620_2	640081.Dsui_3054	5.27e-26	103.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,2KVUM@206389|Rhodocyclales	206389|Rhodocyclales	P	phosphate transport system	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k59_41297_1	436308.Nmar_1794	1.28e-92	299.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_41297_2	673860.AciM339_0296	1.07e-06	50.8	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,3F2M3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
k59_300334_1	652103.Rpdx1_3415	6.59e-108	323.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,3JRD6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	nrtA	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
k59_170988_1	153948.NAL212_2998	2.02e-92	286.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_150821_1	126957.SMAR003199-PA	1.2e-06	55.8	2D1SP@1|root,2SJ4J@2759|Eukaryota,3AH2Y@33154|Opisthokonta,3BZD9@33208|Metazoa,3DF3N@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_31371_1	7159.AAEL011646-PA	3.09e-54	183.0	2E0WI@1|root,2S89W@2759|Eukaryota,397E2@33154|Opisthokonta,3CBQ5@33208|Metazoa,3DSZQ@33213|Bilateria,424KF@6656|Arthropoda,3STV6@50557|Insecta,45B4K@7147|Diptera,45KZ8@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_21277_2	468059.AUHA01000002_gene755	2.33e-11	65.1	COG3023@1|root,COG3023@2|Bacteria,4NE38@976|Bacteroidetes,1INQE@117747|Sphingobacteriia	976|Bacteroidetes	V	N-acetylmuramoyl-L-alanine amidase	amiD	-	3.5.1.28	ko:K01447,ko:K11066	-	-	R04112	RC00064,RC00141	ko00000,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1
k59_161138_1	1121090.KB894691_gene2688	1.88e-19	94.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,4HAXJ@91061|Bacilli,1ZEP3@1386|Bacillus	91061|Bacilli	L	Transposase, Mutator family	B4168_4126	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
k59_310410_1	7159.AAEL017470-PA	4.51e-05	50.1	COG0515@1|root,KOG1152@2759|Eukaryota,38BA6@33154|Opisthokonta,3BC21@33208|Metazoa,3CVIZ@33213|Bilateria,41VZ3@6656|Arthropoda,3SKMJ@50557|Insecta,44ZXN@7147|Diptera,45CCP@7148|Nematocera	33208|Metazoa	T	Serine/Threonine protein kinases, catalytic domain	PASK	GO:0002791,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006417,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010675,GO:0010677,GO:0010817,GO:0010906,GO:0010962,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019222,GO:0019538,GO:0023051,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032270,GO:0032501,GO:0032879,GO:0032881,GO:0032885,GO:0034248,GO:0034250,GO:0035091,GO:0036211,GO:0042592,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043255,GO:0043412,GO:0043467,GO:0043576,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045727,GO:0045912,GO:0046777,GO:0046883,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048871,GO:0050789,GO:0050794,GO:0051046,GO:0051049,GO:0051171,GO:0051173,GO:0051239,GO:0051246,GO:0051247,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070092,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090087,GO:0090276,GO:0097009,GO:0140096,GO:1901564,GO:1903530,GO:2000112,GO:2000113	2.7.11.1	ko:K08801	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PAS_9,Pkinase
k59_290642_1	1038858.AXBA01000010_gene2683	1.67e-12	73.6	28JTG@1|root,2ZTYG@2|Bacteria,1NI0X@1224|Proteobacteria,2U89K@28211|Alphaproteobacteria,3EZH0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2793)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2793
k59_52399_1	1236908.wNo_06870	5.52e-148	433.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,47EUH@766|Rickettsiales	766|Rickettsiales	L	Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity)	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
k59_101875_1	1229909.NSED_09865	0.00077	42.7	COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_101875_2	436308.Nmar_0047	1.97e-62	202.0	COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_281585_1	1131266.ARWQ01000015_gene757	6.76e-237	667.0	COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
k59_241280_1	1038859.AXAU01000020_gene5483	1.6e-50	172.0	COG4177@1|root,COG4177@2|Bacteria,1PSHZ@1224|Proteobacteria,2TVQQ@28211|Alphaproteobacteria,3JTT3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_231426_1	570417.WP1084	2.85e-154	434.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,47FDT@766|Rickettsiales	766|Rickettsiales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_251859_1	6334.EFV58439	9.65e-29	118.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BGB6@33208|Metazoa,3D5G4@33213|Bilateria,40FC4@6231|Nematoda	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve
k59_52408_1	1131266.ARWQ01000008_gene323	5.31e-59	184.0	COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k59_52408_2	1131266.ARWQ01000008_gene322	1.44e-31	114.0	arCOG08024@1|root,arCOG08024@2157|Archaea,41SRU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
k59_192153_1	1236908.wNo_08670	6.4e-135	390.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,47F65@766|Rickettsiales	766|Rickettsiales	M	COG0739 Membrane proteins related to metalloendopeptidases	nlpD2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_192153_2	570417.WP1214	1.01e-36	129.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,47ET9@766|Rickettsiales	766|Rickettsiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
k59_202130_1	768671.ThimaDRAFT_3740	6.64e-20	94.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin PilY1	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_82690_1	1236908.wNo_04790	7.59e-184	517.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,47F0P@766|Rickettsiales	766|Rickettsiales	E	COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes	spl1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_122324_1	1131553.JIBI01000003_gene1664	2.97e-21	95.5	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,2WGR6@28216|Betaproteobacteria,372WU@32003|Nitrosomonadales	28216|Betaproteobacteria	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
k59_142205_1	7176.CPIJ003546-PA	1.37e-33	132.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_281601_1	1236908.wNo_00550	5.84e-175	489.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,47EXU@766|Rickettsiales	766|Rickettsiales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k59_271978_1	1236908.wNo_09810	4.6e-76	251.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,47ETW@766|Rickettsiales	766|Rickettsiales	L	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	recB	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_202145_1	1236908.wNo_05570	4.78e-105	310.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
k59_262015_1	1120956.JHZK01000002_gene994	1.1e-80	253.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,1JP94@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_142216_1	1236908.wNo_03970	1.2e-270	752.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,47F1Q@766|Rickettsiales	766|Rickettsiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_262022_1	1122214.AQWH01000016_gene1581	8.99e-07	52.4	2BPZY@1|root,32IU0@2|Bacteria,1MYBM@1224|Proteobacteria,2UBMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
k59_62388_1	1236908.wNo_02110	1.97e-06	57.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,2UA2F@28211|Alphaproteobacteria,47F95@766|Rickettsiales	766|Rickettsiales	O	ankyrin repeat	-	-	-	ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
k59_101926_1	436308.Nmar_1312	6.81e-09	56.2	COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
k59_101926_2	458817.Shal_1502	8.32e-06	50.4	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,2Q8KK@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.25,5.1.3.6	ko:K08679,ko:K17947	ko00520,ko00523,ko01100,ko01130,map00520,map00523,map01100,map01130	-	R01385,R10279	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_12460_1	7091.BGIBMGA011035-TA	7.7e-43	159.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VNK@33154|Opisthokonta,3CB3V@33208|Metazoa,3DSCG@33213|Bilateria,428FM@6656|Arthropoda,3SSDK@50557|Insecta,44A45@7088|Lepidoptera	33208|Metazoa	L	gag-polypeptide of LTR copia-type	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2
k59_202163_1	1131266.ARWQ01000001_gene1145	5.37e-101	307.0	COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_32718_1	400682.PAC_15723685	2.15e-38	149.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_49989_1	1163617.SCD_n00952	5.53e-84	263.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_129806_1	436308.Nmar_1577	2.42e-95	293.0	COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota	651137|Thaumarchaeota	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_129806_2	1131266.ARWQ01000009_gene964	5.69e-17	79.0	COG1940@1|root,arCOG04280@2157|Archaea,41SWX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
k59_139785_1	436308.Nmar_1477	9.96e-104	322.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_59972_1	7029.ACYPI062999-PA	3.71e-76	251.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_10117_1	582744.Msip34_2593	8.96e-57	199.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,2KKXA@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_179670_2	436308.Nmar_0850	3.53e-78	240.0	arCOG07810@1|root,arCOG07810@2157|Archaea,41T26@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
k59_269433_1	7425.NV20113-PA	3.98e-24	112.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	1.1.1.206	ko:K08081,ko:K21596	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R02832	RC00144	ko00000,ko00001,ko01000,ko03000	-	-	-	Exo_endo_phos_2,RVT_1,RVT_3
k59_30070_1	7029.ACYPI081986-PA	2.63e-05	47.4	2E1I0@1|root,2S8UZ@2759|Eukaryota,3A9DK@33154|Opisthokonta,3BV6P@33208|Metazoa	7029.ACYPI081986-PA|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_309380_2	13037.EHJ76699	3.75e-28	116.0	COG2940@1|root,KOG1141@2759|Eukaryota,3912T@33154|Opisthokonta,3C6TI@33208|Metazoa,3DMT1@33213|Bilateria,424AI@6656|Arthropoda,3STH1@50557|Insecta,448WP@7088|Lepidoptera	33208|Metazoa	S	Helitron helicase-like domain at N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Helitron_like_N
k59_309380_3	7176.CPIJ009314-PA	1.52e-59	207.0	COG0507@1|root,KOG1744@1|root,KOG4162@1|root,KOG0987@2759|Eukaryota,KOG1744@2759|Eukaryota,KOG4162@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda,3SP5N@50557|Insecta,455R4@7147|Diptera,45DRP@7148|Nematocera	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_40041_1	266265.Bxe_B0283	5.34e-105	319.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2W8ET@28216|Betaproteobacteria,1KCUI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k59_99884_1	1123519.PSJM300_02130	4.48e-21	97.4	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1Z1JU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k59_129838_1	31234.CRE02412	3.03e-58	206.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,40S01@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_149744_1	1237149.C900_03408	1.37e-07	55.5	COG2755@1|root,COG3209@1|root,COG4733@1|root,COG2755@2|Bacteria,COG3209@2|Bacteria,COG4733@2|Bacteria,4NJGD@976|Bacteroidetes,47VZA@768503|Cytophagia	976|Bacteroidetes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
k59_199685_2	1121949.AQXT01000002_gene1437	3.13e-51	169.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,43XDN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	dapH	-	-	-	-	-	-	-	-	-	-	-	Hexapep
k59_269435_1	1391188.A0A068EMC0_9CAUD	1.23e-18	95.1	4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses  no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae	10662|Myoviridae	S	exonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_269435_6	136993.KB900626_gene1839	3.83e-17	80.9	COG1917@1|root,COG1917@2|Bacteria,1N6Q0@1224|Proteobacteria,2UKI2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_109886_1	1236908.wNo_03550	2.86e-39	140.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria,2TRFG@28211|Alphaproteobacteria,47G54@766|Rickettsiales	766|Rickettsiales	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
k59_109886_2	1236908.wNo_03560	6.6e-279	763.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,47EZB@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
k59_259524_1	7029.ACYPI52857-PA	1.12e-46	177.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_249529_1	436308.Nmar_0495	1.27e-123	363.0	COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_249529_2	1229909.NSED_02485	3.26e-26	107.0	COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufD	-	-	-	ko:K09014,ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_40384_2	351160.RCIX2695	1.65e-10	58.9	arCOG11653@1|root,arCOG11653@2157|Archaea,2Y5YM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_259841_1	436308.Nmar_0264	6.19e-17	82.4	arCOG08785@1|root,arCOG08785@2157|Archaea,41SVD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	-
k59_180034_1	391038.Bphy_5504	2.37e-86	283.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k59_229923_1	570417.WP0673	9.24e-99	291.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,47F5E@766|Rickettsiales	766|Rickettsiales	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_229923_2	570417.WP0672	9.22e-47	149.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,47FRK@766|Rickettsiales	766|Rickettsiales	J	Ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_10467_2	1343740.M271_11220	0.000685	43.1	COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2I9MP@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,PS-DH,adh_short_C2,ketoacyl-synt
k59_249824_1	281687.CJA15137	8.97e-05	50.4	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3DKJZ@33213|Bilateria,40GWW@6231|Nematoda,1KZYW@119089|Chromadorea,412EV@6236|Rhabditida	33208|Metazoa	K	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_150050_1	460265.Mnod_4479	2.43e-104	307.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TQZ7@28211|Alphaproteobacteria,1JSBB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	gltK	-	-	ko:K02029,ko:K10002	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
k59_239777_1	7029.ACYPI38036-PA	8.5e-31	123.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_487_2	7029.ACYPI38786-PA	7.81e-34	135.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3DDWX@33213|Bilateria,42228@6656|Arthropoda,3SPN5@50557|Insecta,3ED9B@33342|Paraneoptera	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVP,RVT_1,Retrotrans_gag,rve,zf-CCHC
k59_130270_1	1229909.NSED_01125	3.8e-86	275.0	COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
k59_150058_1	1229909.NSED_07860	1.13e-96	298.0	arCOG06613@1|root,arCOG06613@2157|Archaea,41T0Z@651137|Thaumarchaeota	651137|Thaumarchaeota	V	AIPR protein	-	-	-	-	-	-	-	-	-	-	-	-	AIPR
k59_229933_2	323848.Nmul_A1541	9.19e-49	173.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,371VX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_180056_1	1123393.KB891333_gene2538	8e-24	99.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_10481_1	7070.TC004227-PA	3.88e-46	173.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_239787_1	1236908.wNo_06480	2.58e-106	334.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,47F1J@766|Rickettsiales	766|Rickettsiales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
k59_507_1	330214.NIDE1131	1.8e-117	360.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
k59_150069_1	570417.WP1061	2.9e-50	160.0	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria,47FTX@766|Rickettsiales	766|Rickettsiales	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
k59_150069_2	1236908.wNo_06200	3.78e-102	298.0	COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2TY73@28211|Alphaproteobacteria,47GU6@766|Rickettsiales	766|Rickettsiales	P	Domain of unknown function (DUF4040)	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040
k59_50428_1	7425.NV17332-PA	2.84e-50	182.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve
k59_160245_1	580332.Slit_0113	9.94e-11	62.8	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,44VC5@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_160245_2	1163617.SCD_n02945	3.38e-59	201.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria	28216|Betaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_30504_1	436308.Nmar_1784	4.8e-06	45.4	arCOG08810@1|root,arCOG08810@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_30504_2	931277.C448_06780	1.22e-14	72.4	COG0122@1|root,arCOG00464@2157|Archaea,2XV7J@28890|Euryarchaeota,23SXP@183963|Halobacteria	183963|Halobacteria	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_190078_1	570417.WP0891	7.24e-96	290.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,47ETV@766|Rickettsiales	766|Rickettsiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_10514_1	31234.CRE17428	1.7e-07	59.3	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,40I7B@6231|Nematoda,1KYXI@119089|Chromadorea,4159F@6236|Rhabditida	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,Phlebovirus_G2,RVT_1,rve
k59_299685_1	6183.Smp_195130.1	4.83e-15	80.5	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_130325_1	330214.NIDE1017	8.81e-133	385.0	COG0772@1|root,COG0772@2|Bacteria,3J0IA@40117|Nitrospirae	40117|Nitrospirae	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_150105_1	570417.WP0891	1.36e-134	391.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,47ETV@766|Rickettsiales	766|Rickettsiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_269866_1	754477.Q7C_624	2.87e-41	138.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,460ZG@72273|Thiotrichales	72273|Thiotrichales	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
k59_269867_1	395019.Bmul_2081	1.78e-108	330.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,1K0C6@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k59_249902_1	522306.CAP2UW1_3923	8.92e-79	241.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KQ3X@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k59_80498_1	1038859.AXAU01000014_gene1378	6.68e-93	285.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria	1224|Proteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_90425_2	1131266.ARWQ01000002_gene534	7.21e-40	136.0	COG0041@1|root,arCOG02464@2157|Archaea,41SN4@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
k59_239838_1	7176.CPIJ004626-PA	2.85e-82	260.0	2D3G7@1|root,2SRFN@2759|Eukaryota,3AMW9@33154|Opisthokonta,3C1BW@33208|Metazoa	33208|Metazoa	S	Retrotransposon gag protein	-	-	-	-	-	-	-	-	-	-	-	-	Retrotrans_gag
k59_200158_1	1236908.wNo_10440	1.36e-05	45.8	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,47EX0@766|Rickettsiales	766|Rickettsiales	LU	DNA processing protein	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
k59_200158_2	570417.WP1368	4.72e-88	258.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,47FHH@766|Rickettsiales	766|Rickettsiales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
k59_90435_1	1236908.wNo_09140	8.02e-228	675.0	COG1672@1|root,COG5539@1|root,COG1672@2|Bacteria,COG5539@2|Bacteria	2|Bacteria	O	protein K27-linked deubiquitination	-	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0036210,GO:0036211,GO:0043087,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044033,GO:0044238,GO:0046872,GO:0050568,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009,GO:0071704,GO:0140096,GO:1901564	-	ko:K06921,ko:K15354	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	AAA_16,KAP_NTPase,Mrr_cat,NACHT,SIR2_2,Tox-PLDMTX
k59_30572_1	436308.Nmar_1792	1.97e-170	492.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_31921_1	330214.NIDE0895	5.67e-70	217.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
k59_131746_1	1459636.NTE_03542	1.29e-18	80.5	COG3432@1|root,arCOG01063@2157|Archaea,41T7S@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_131746_2	1459636.NTE_03541	2.84e-34	122.0	arCOG11425@1|root,arCOG11425@2157|Archaea,41T5C@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_161740_1	991905.SL003B_1861	5.89e-06	53.5	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,4BRPT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	MA20_38120	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
k59_230899_1	436308.Nmar_1038	1.34e-64	202.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_230899_2	1229909.NSED_06105	7.6e-90	280.0	COG1793@1|root,arCOG01347@2157|Archaea,41SCK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
k59_133208_2	7029.ACYPI009216-PA	1.29e-53	197.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_52991_2	7425.NV31842-PA	3.67e-38	141.0	2F3G8@1|root,2T4FJ@2759|Eukaryota,38Y72@33154|Opisthokonta,3C5TK@33208|Metazoa,3DM4J@33213|Bilateria,42320@6656|Arthropoda	7425.NV31842-PA|-	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_192765_1	1236908.wNo_02070	1.06e-99	312.0	COG0500@1|root,COG2226@2|Bacteria,1PXEH@1224|Proteobacteria,2UQTX@28211|Alphaproteobacteria,47G4K@766|Rickettsiales	766|Rickettsiales	Q	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_133217_1	570417.WP1217	9.09e-58	179.0	28U03@1|root,2ZG6G@2|Bacteria	2|Bacteria	S	PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
k59_133217_2	570417.WP1218	5.01e-17	77.4	COG1564@1|root,COG1564@2|Bacteria,1RCEI@1224|Proteobacteria,2VA92@28211|Alphaproteobacteria,47FVC@766|Rickettsiales	766|Rickettsiales	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
k59_93374_1	7029.ACYPI23117-PA	2.14e-17	86.3	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_182850_1	1131266.ARWQ01000009_gene955	1.27e-58	192.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
k59_72227_1	7070.TC008528-PA	1.1e-93	306.0	2CN36@1|root,2QTNN@2759|Eukaryota,38FJC@33154|Opisthokonta,3BM27@33208|Metazoa,3D0HQ@33213|Bilateria,421UG@6656|Arthropoda,3SQ3A@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_93384_1	1485544.JQKP01000002_gene1562	4.15e-69	226.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,44VJY@713636|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k59_102390_1	1007103.AFHW01000025_gene349	1.03e-06	50.1	COG2199@1|root,COG2199@2|Bacteria,1UQA9@1239|Firmicutes,4HBNE@91061|Bacilli,26T82@186822|Paenibacillaceae	91061|Bacilli	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,PAS_4,PAS_9
k59_102390_2	153948.NAL212_1221	8.05e-38	136.0	28P0I@1|root,2ZBX5@2|Bacteria,1RB8U@1224|Proteobacteria,2VQ6K@28216|Betaproteobacteria,37331@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3025)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3025
k59_93387_1	1131266.ARWQ01000001_gene1123	1.19e-87	272.0	COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Phenylalanyl-tRNA synthetase alpha subunit	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
k59_83371_1	288000.BBta_1460	5.07e-96	299.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_282159_1	7425.NV21425-PA	1.32e-43	164.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_222504_1	7070.TC011220-PA	1.27e-72	245.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_102391_1	1430440.MGMSRv2_3490	2.19e-58	186.0	COG2227@1|root,COG2227@2|Bacteria,1QYVF@1224|Proteobacteria,2TZ70@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_102391_2	870187.Thini_3578	1.7e-39	135.0	COG3012@1|root,COG3012@2|Bacteria,1N4HZ@1224|Proteobacteria,1SFB1@1236|Gammaproteobacteria,462H1@72273|Thiotrichales	72273|Thiotrichales	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_311962_1	1131266.ARWQ01000005_gene809	4.61e-127	372.0	COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_152470_2	1229909.NSED_03355	1.79e-130	408.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_63025_3	1121267.JHZL01000002_gene1027	4.5e-40	147.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42M4P@68525|delta/epsilon subdivisions,2YME6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	UDP-N-acetylglucosamine 4,6-dehydratase	pseB	-	4.2.1.115	ko:K15894	ko00520,map00520	-	R09697	RC02609	ko00000,ko00001,ko01000	-	-	-	Polysacc_synt_2
k59_93409_1	570417.WP0526	1.41e-134	397.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,47FMX@766|Rickettsiales	766|Rickettsiales	O	COG0760 Parvulin-like peptidyl-prolyl isomerase	surA	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
k59_301869_1	570417.WP0693	6.07e-148	422.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,Hydrolase_4
k59_301869_2	1236908.wNo_03600	1.89e-66	204.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,47GCV@766|Rickettsiales	766|Rickettsiales	H	Dihydrofolate reductase	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_272653_1	1163617.SCD_n01869	6.04e-110	318.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
k59_272653_2	395494.Galf_0409	6.05e-18	82.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,44V7W@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_2912_1	3750.XP_008349640.1	2.34e-05	45.4	COG2801@1|root,KOG1192@1|root,KOG0017@2759|Eukaryota,KOG1192@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids	35493|Streptophyta	H	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Chromo,RVP_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_282192_1	1236908.wNo_11360	1e-149	434.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,47EVY@766|Rickettsiales	766|Rickettsiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_311999_1	1121285.AUFK01000014_gene2882	3.38e-18	84.3	29CEM@1|root,2ZZD2@2|Bacteria,4NY53@976|Bacteroidetes,1I9R3@117743|Flavobacteriia,3ZTV5@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_93446_1	7425.NV18233-PA	4.55e-43	160.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXJQ@33208|Metazoa,3DGER@33213|Bilateria,422ER@6656|Arthropoda,3SR16@50557|Insecta,46M71@7399|Hymenoptera	33208|Metazoa	S	Domain of unknown function (DUF4780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780,Exo_endo_phos_2,RNase_H,RVT_1
k59_172930_2	1235457.C404_12300	3.52e-91	286.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,1K0R8@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_192843_1	1229909.NSED_01205	6.18e-139	396.0	COG0479@1|root,arCOG00962@2157|Archaea,41SAW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
k59_192843_2	436308.Nmar_0262	1.36e-59	185.0	COG2151@1|root,arCOG01845@2157|Archaea,41SQV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
k59_192843_3	1131266.ARWQ01000003_gene1504	1.5e-182	521.0	COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k59_163249_1	7176.CPIJ007702-PA	2.1e-58	194.0	2E0WI@1|root,2S89W@2759|Eukaryota,397E2@33154|Opisthokonta,3CBQ5@33208|Metazoa,3DSZQ@33213|Bilateria,424KF@6656|Arthropoda,3STV6@50557|Insecta,45B4K@7147|Diptera,45KZ8@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_33444_1	1265502.KB905933_gene2029	4.7e-62	208.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4A9M6@80864|Comamonadaceae	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_241837_1	882378.RBRH_02016	1.62e-36	127.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,1K6XN@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Lactoylglutathione lyase	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_241837_2	999541.bgla_1g07770	3.02e-34	117.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,1KA31@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
k59_212707_1	1236908.wNo_04170	1.02e-146	417.0	COG0545@1|root,COG0545@2|Bacteria,1RAV0@1224|Proteobacteria,2UYE2@28211|Alphaproteobacteria,47G9B@766|Rickettsiales	766|Rickettsiales	O	protein peptidyl-prolyl isomerization	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
k59_152519_1	281687.CJA19499b	2.37e-13	74.7	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DIPZ@33213|Bilateria,40KHH@6231|Nematoda,1M3X1@119089|Chromadorea,411HK@6236|Rhabditida	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_122943_1	1123393.KB891327_gene276	4.14e-50	169.0	COG3821@1|root,COG3821@2|Bacteria,1PPR3@1224|Proteobacteria,2VR42@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
k59_202823_1	1242864.D187_006660	4.74e-96	292.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales	28221|Deltaproteobacteria	H	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_182972_1	570417.WP1083	2.53e-120	351.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,47G34@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
k59_23130_1	1229909.NSED_05715	4.44e-143	410.0	COG3243@1|root,arCOG06344@2157|Archaea,41SEX@651137|Thaumarchaeota	651137|Thaumarchaeota	I	TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_43498_2	222891.NSE_0331	2.35e-31	117.0	2EV6Q@1|root,33NMG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_142962_1	1157708.KB907465_gene304	1.21e-40	148.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VH3X@28216|Betaproteobacteria,4ACJ7@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_43506_1	656519.Halsa_0054	8.83e-59	192.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales	186801|Clostridia	L	Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
k59_72347_1	285535.JOEY01000019_gene2452	4.4e-39	144.0	COG4177@1|root,COG4177@2|Bacteria,2GNZK@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_231988_1	1131266.ARWQ01000019_gene861	6.25e-94	303.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_163312_1	666681.M301_2599	6.78e-81	254.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KKBX@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_122979_1	570417.WP0861	2.96e-244	674.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,47EVX@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k59_212746_1	555793.WSK_2479	8.66e-14	70.1	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,2K4ID@204457|Sphingomonadales	204457|Sphingomonadales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_212746_2	153948.NAL212_1027	1.2e-47	162.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,372FI@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
k59_83521_1	7897.ENSLACP00000006966	1.68e-13	75.9	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,487I3@7711|Chordata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,Exo_endo_phos_2,RVT_1
k59_133417_1	329726.AM1_6368	8.55e-45	147.0	COG4683@1|root,COG4683@2|Bacteria,1GHR5@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
k59_272748_1	135651.CBN15281	5.05e-18	89.4	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3C0WJ@33208|Metazoa,3E5AA@33213|Bilateria,40RE5@6231|Nematoda,1M8IG@119089|Chromadorea,40WYR@6236|Rhabditida	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17
k59_222594_2	634177.GLX_16440	2.02e-09	69.3	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2JQ4K@204441|Rhodospirillales	204441|Rhodospirillales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_64680_2	1131266.ARWQ01000008_gene335	7.81e-77	240.0	COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_194105_1	570417.WP1054	8.34e-196	548.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,47EUY@766|Rickettsiales	766|Rickettsiales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k59_184865_1	1454004.AW11_01763	3.05e-75	241.0	2F0EN@1|root,33THP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114515_1	436308.Nmar_0764	1.27e-52	182.0	COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	CBS domain	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	CBS,TrkH
k59_55019_1	1459636.NTE_03553	3.98e-159	456.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k59_4538_1	1229909.NSED_09645	1.59e-32	124.0	COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
k59_4538_2	436308.Nmar_0003	8.66e-31	114.0	arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_174679_1	933801.Ahos_2218	1.78e-24	102.0	COG0071@1|root,arCOG08402@1|root,arCOG01833@2157|Archaea,arCOG08402@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_313562_1	455436.DS989810_gene494	1.27e-15	76.6	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,465AV@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_165171_1	7176.CPIJ018198-PA	7.3e-53	176.0	2D8RZ@1|root,2TBAA@2759|Eukaryota,396FP@33154|Opisthokonta,3CAU4@33208|Metazoa,3DS1T@33213|Bilateria,4286G@6656|Arthropoda,3SSCU@50557|Insecta,457E2@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_85451_1	936053.I1BP59	2.64e-50	187.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,1GXGQ@112252|Fungi incertae sedis	4751|Fungi	L	retrotransposable element tf2 155 kda protein type 1-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve,zf-CCHC
k59_303403_1	436308.Nmar_0100	2.31e-175	501.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_303403_2	436308.Nmar_0101	2.26e-13	69.3	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_233365_1	2340.JV46_28950	3.82e-53	192.0	2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria	1224|Proteobacteria	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_35333_1	436308.Nmar_1446	1.18e-11	60.1	COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_95544_1	1459636.NTE_00018	9.48e-80	246.0	COG0115@1|root,arCOG02297@2157|Archaea,41SD5@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_85467_1	10224.XP_002740782.1	1.08e-59	209.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,rve,zf-CCHC
k59_303407_1	570417.WP0295	3.03e-144	427.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	anK3	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,SUFU
k59_95563_1	570417.WP0614	1.01e-99	289.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,47FMT@766|Rickettsiales	766|Rickettsiales	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_73712_1	543913.D521_0300	0.000133	43.9	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,1KQ03@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
k59_73712_2	511.JT27_13775	2.52e-27	110.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,3T1W3@506|Alcaligenaceae	28216|Betaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_194682_1	436308.Nmar_0333	8.06e-47	172.0	arCOG08778@1|root,arCOG08778@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_4590_1	469383.Cwoe_3251	1.32e-39	149.0	COG1372@1|root,COG1533@1|root,COG1372@2|Bacteria,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria	84995|Rubrobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_313602_1	1236908.wNo_06470	7.55e-172	503.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,47EVS@766|Rickettsiales	766|Rickettsiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_274623_1	570417.WP0530	4.16e-146	423.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,47FWN@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_165243_1	1352941.M877_29430	5.23e-51	179.0	COG2936@1|root,COG2936@2|Bacteria,2GKZH@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_65414_1	7668.SPU_003371-tr	2.46e-18	92.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_184960_1	1229909.NSED_09095	1.49e-78	249.0	COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
k59_35378_1	7159.AAEL017571-PA	1.91e-58	197.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_194712_1	7070.TC010973-PA	1.65e-26	112.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T04Y@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_224344_1	570417.WP1279	8.85e-55	187.0	COG0666@1|root,COG0666@2|Bacteria,1PEAC@1224|Proteobacteria,2UV89@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ankyrin repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_214608_1	163164.WD_0560	1.46e-95	287.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,47ET3@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_174747_1	570417.WP1051	7.29e-57	196.0	COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gram_pos_anchor,LRR_5,YSIRK_signal,YadA_anchor,YadA_head,YadA_stalk
k59_233406_1	1229909.NSED_01295	1.4e-27	108.0	COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_233406_2	1131266.ARWQ01000015_gene762	1.27e-45	159.0	COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_135392_1	768671.ThimaDRAFT_4037	2.62e-60	202.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,1SDJ1@1236|Gammaproteobacteria,1X0RY@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_274643_1	1236908.wNo_08890	5.07e-12	64.7	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,47EW3@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_114597_1	570417.WP1142	4.07e-154	439.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,47F4B@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k59_165294_1	1163617.SCD_n01244	2.45e-54	182.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria	28216|Betaproteobacteria	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
k59_204590_1	7668.SPU_001338-tr	2.23e-23	105.0	2CMP4@1|root,2QR56@2759|Eukaryota,39NE6@33154|Opisthokonta,3CPYU@33208|Metazoa,3E641@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_313654_1	400682.PAC_15704621	3.73e-78	246.0	COG1132@1|root,KOG0055@2759|Eukaryota,39Z4B@33154|Opisthokonta,3BNXZ@33208|Metazoa	33208|Metazoa	Q	Sulfate thiosulfate import ATP-binding protein cysA-like	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
k59_283890_1	1454004.AW11_01763	2.35e-83	262.0	2F0EN@1|root,33THP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_73762_1	7070.TC016101-PA	4.29e-74	250.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQX5@50557|Insecta	33208|Metazoa	C	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.2.29	ko:K15407	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_135426_2	1123060.JONP01000012_gene2879	2.05e-26	101.0	COG0251@1|root,COG0251@2|Bacteria,1REJQ@1224|Proteobacteria	1224|Proteobacteria	J	Endoribonuclease L-PSP	MA20_01450	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
k59_85563_1	570417.WP0487	4.38e-161	452.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,47F8T@766|Rickettsiales	766|Rickettsiales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
k59_85565_1	7029.ACYPI008531-PA	6.36e-35	138.0	COG2801@1|root,KOG3510@1|root,KOG0017@2759|Eukaryota,KOG3510@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EBZ8@33342|Paraneoptera	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_95664_1	987059.RBXJA2T_16907	3.47e-40	144.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1KJX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_95664_2	1005048.CFU_4391	4.22e-29	107.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,474C5@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
k59_116105_1	330214.NIDE0760	7.93e-91	278.0	COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae	40117|Nitrospirae	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
k59_196550_1	436308.Nmar_0923	1.45e-50	161.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
k59_67608_1	1229909.NSED_03690	1.3e-08	54.3	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
k59_304828_1	1312954.KI914877_gene1024	5.63e-18	84.3	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,1W8CU@1268|Micrococcaceae	201174|Actinobacteria	S	Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
k59_304828_2	436308.Nmar_0061	4.44e-122	352.0	COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_146393_1	570417.WP0274	2.91e-54	178.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K20480	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_19,HTH_26,HTH_3,HTH_31
k59_146393_2	570417.WP0273	2.51e-33	122.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K20480	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_19,HTH_26,HTH_3,HTH_31
k59_266638_1	395493.BegalDRAFT_0478	7.38e-26	104.0	COG4968@1|root,COG4968@2|Bacteria,1QUZW@1224|Proteobacteria,1T31D@1236|Gammaproteobacteria,463V3@72273|Thiotrichales	72273|Thiotrichales	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_26635_2	887062.HGR_08164	1.47e-30	117.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2WG6Y@28216|Betaproteobacteria,4AJUH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_266639_1	1229909.NSED_09625	8.3e-46	156.0	arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
k59_87481_1	398580.Dshi_0775	2.69e-124	362.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CE	Tartrate dehydrogenase	MA20_16515	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
k59_304838_1	31234.CRE05815	1.54e-41	161.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3DKXU@33213|Bilateria,40IDJ@6231|Nematoda,1M1NS@119089|Chromadorea,40U7W@6236|Rhabditida	33208|Metazoa	B	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,Glycoprotein_B,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_146404_2	436308.Nmar_0987	6.36e-32	119.0	COG1405@1|root,arCOG01981@2157|Archaea,41SYU@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_116122_2	1396141.BATP01000060_gene4765	1.13e-06	57.8	COG0028@1|root,COG2730@1|root,COG2755@1|root,COG2931@1|root,COG3506@1|root,COG3637@1|root,COG4733@1|root,COG5184@1|root,COG0028@2|Bacteria,COG2730@2|Bacteria,COG2755@2|Bacteria,COG2931@2|Bacteria,COG3506@2|Bacteria,COG3637@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,46Z9Q@74201|Verrucomicrobia,2IVEQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	DEGMUZ	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
k59_47484_1	436308.Nmar_0021	1.78e-108	330.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
k59_244714_1	391613.RTM1035_09833	2.31e-98	305.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_105522_1	436308.Nmar_1309	4.32e-88	278.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18594	ko00720,ko01120,map00720,map01120	-	R03157	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_266666_1	7029.ACYPI066973-PA	7.87e-29	120.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3DE2J@33213|Bilateria	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_47498_1	90675.XP_010495765.1	2.36e-27	115.0	COG2801@1|root,KOG0017@2759|Eukaryota,37SNQ@33090|Viridiplantae,3GHRQ@35493|Streptophyta	35493|Streptophyta	L	spliceosomal complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_245136_1	640081.Dsui_0604	7.73e-118	344.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,2KVBG@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_6723_1	330214.NIDE3548	7.26e-48	166.0	COG0104@1|root,COG0104@2|Bacteria,3J0FV@40117|Nitrospirae	40117|Nitrospirae	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_126843_1	1131266.ARWQ01000001_gene1192	5.67e-95	295.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
k59_105956_1	1236908.wNo_06910	0.0	1144.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,47EU1@766|Rickettsiales	766|Rickettsiales	C	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
k59_37994_1	570417.WP1259	1.16e-116	352.0	COG3505@1|root,COG3505@2|Bacteria,1MV1G@1224|Proteobacteria,2TR6N@28211|Alphaproteobacteria,47EW8@766|Rickettsiales	766|Rickettsiales	U	Type IV secretion system protein VirD4	virD4	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
k59_17075_1	13037.EHJ73416	1.65e-32	135.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,41V5R@6656|Arthropoda,3SINZ@50557|Insecta	33208|Metazoa	S	RNase H	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_57707_1	234826.AM730	1.07e-10	61.6	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,47EUE@766|Rickettsiales	766|Rickettsiales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
k59_138114_1	1454004.AW11_01763	1.11e-98	306.0	2F0EN@1|root,33THP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_17078_1	1123073.KB899242_gene1461	1.44e-108	330.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1XA61@135614|Xanthomonadales	135614|Xanthomonadales	CE	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2
k59_6747_1	570417.WP0559	1.88e-57	184.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,47F7X@766|Rickettsiales	766|Rickettsiales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_6747_2	570417.WP1164	4.89e-281	768.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,47EUU@766|Rickettsiales	766|Rickettsiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_197176_1	7230.FBpp0173013	6.87e-45	163.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQCE@50557|Insecta,455QK@7147|Diptera,45VV1@7214|Drosophilidae	33208|Metazoa	L	Nucleic acid binding. It is involved in the biological process described with DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_88121_1	7176.CPIJ019473-PA	6.99e-14	76.3	COG5028@1|root,KOG1984@2759|Eukaryota	2759|Eukaryota	U	ER to Golgi vesicle-mediated transport	SEC24C	GO:0000149,GO:0000902,GO:0002376,GO:0002474,GO:0002478,GO:0002495,GO:0002504,GO:0002790,GO:0003330,GO:0003331,GO:0003674,GO:0005048,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005798,GO:0005829,GO:0005937,GO:0006810,GO:0006886,GO:0006888,GO:0006900,GO:0006901,GO:0006903,GO:0006996,GO:0007029,GO:0007030,GO:0007034,GO:0007163,GO:0007275,GO:0007424,GO:0007517,GO:0008104,GO:0008150,GO:0008270,GO:0008360,GO:0009306,GO:0009653,GO:0009987,GO:0010256,GO:0012505,GO:0012506,GO:0012507,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016203,GO:0019882,GO:0019884,GO:0019886,GO:0022407,GO:0022409,GO:0022603,GO:0022604,GO:0022607,GO:0030011,GO:0030117,GO:0030120,GO:0030127,GO:0030133,GO:0030134,GO:0030135,GO:0030155,GO:0030198,GO:0030427,GO:0030658,GO:0030659,GO:0030660,GO:0030662,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032509,GO:0032511,GO:0032879,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0033218,GO:0034394,GO:0034613,GO:0034622,GO:0035148,GO:0035149,GO:0035150,GO:0035151,GO:0035152,GO:0035158,GO:0035159,GO:0035239,GO:0035295,GO:0035296,GO:0035459,GO:0040003,GO:0042175,GO:0042277,GO:0042335,GO:0042886,GO:0042995,GO:0043062,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043332,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0045184,GO:0045324,GO:0045785,GO:0046872,GO:0046903,GO:0046907,GO:0046914,GO:0048002,GO:0048070,GO:0048079,GO:0048081,GO:0048087,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048475,GO:0048513,GO:0048518,GO:0048522,GO:0048646,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051286,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0060538,GO:0060541,GO:0061024,GO:0061061,GO:0065003,GO:0065007,GO:0065008,GO:0070727,GO:0070971,GO:0071702,GO:0071705,GO:0071711,GO:0071840,GO:0071944,GO:0071985,GO:0072657,GO:0072659,GO:0090066,GO:0090110,GO:0090114,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:0098827,GO:0120025,GO:0120038,GO:1903053,GO:1903055,GO:1903530,GO:1903532,GO:1990778,GO:2000026	-	ko:K14007	ko04141,map04141	M00404	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	Gelsolin,Sec23_BS,Sec23_helical,Sec23_trunk,zf-Sec23_Sec24
k59_38011_1	330214.NIDE3937	5.14e-96	311.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
k59_68173_1	7029.ACYPI071420-PA	1.9e-19	93.2	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa	33208|Metazoa	L	steroid hormone mediated signaling pathway	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_245178_1	1123366.TH3_21820	3.04e-29	113.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,2JW1A@204441|Rhodospirillales	204441|Rhodospirillales	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_245178_2	1187851.A33M_1936	1.65e-65	203.0	COG3293@1|root,COG3293@2|Bacteria,1RFRK@1224|Proteobacteria,2U8TH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_285885_1	1236908.wNo_10050	5.62e-162	464.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,47F88@766|Rickettsiales	766|Rickettsiales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_256725_1	1236908.wNo_02100	5.7e-80	242.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_256725_2	1236908.wNo_02090	6.99e-94	280.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,47GQI@766|Rickettsiales	766|Rickettsiales	GM	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_6766_1	4565.Traes_2DL_8A90A6C4F.2	3.03e-50	184.0	COG2801@1|root,KOG0017@2759|Eukaryota,37NRU@33090|Viridiplantae,3GGV0@35493|Streptophyta,3M4R8@4447|Liliopsida,3IK9Z@38820|Poales	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	RVP_2,RVT_1,Retrotrans_gag,rve
k59_17116_1	7260.FBpp0254607	2.15e-25	112.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_105977_1	570417.WP0166	1.98e-120	354.0	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,47F2V@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_217010_1	2711.XP_006485859.1	3.2e-06	55.1	COG0515@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1187@2759|Eukaryota,37RIF@33090|Viridiplantae,3GFVM@35493|Streptophyta	35493|Streptophyta	L	Cysteine-rich RLK (RECEPTOR-like protein kinase) 8	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_3,rve
k59_98414_1	981327.F925_02379	2.56e-98	308.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,3NJC4@468|Moraxellaceae	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_138159_1	1459636.NTE_02267	1.09e-55	184.0	COG0179@1|root,arCOG00235@2157|Archaea,41S5K@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k59_105979_1	1229909.NSED_08285	1.87e-53	167.0	arCOG08672@1|root,arCOG08672@2157|Archaea,41SU2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_105979_2	436308.Nmar_1507	3.77e-39	133.0	arCOG10587@1|root,arCOG10587@2157|Archaea,41SVM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_105979_3	436308.Nmar_1508	1.76e-54	174.0	COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
k59_245202_1	570417.WP1056	1.82e-113	342.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,47F25@766|Rickettsiales	766|Rickettsiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_88164_1	391624.OIHEL45_18826	8.06e-10	63.5	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
k59_69390_1	999541.bgla_2g17310	2.72e-19	85.5	COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,2VUD7@28216|Betaproteobacteria,1KASE@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
k59_69397_2	1187851.A33M_0952	1.45e-40	145.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
k59_286918_1	69319.XP_008557768.1	2.53e-34	132.0	2CWTA@1|root,2RV75@2759|Eukaryota,38WQJ@33154|Opisthokonta,3C6CU@33208|Metazoa,3DME6@33213|Bilateria,42CM4@6656|Arthropoda,3SY8M@50557|Insecta,46MJ3@7399|Hymenoptera	69319.XP_008557768.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_258008_1	6669.EFX73367	2.33e-10	63.9	2CIKA@1|root,2S3RQ@2759|Eukaryota,3A5TG@33154|Opisthokonta,3BTMS@33208|Metazoa,3D9XA@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RNase_H
k59_49362_1	1144343.PMI41_01432	1.47e-76	253.0	COG0463@1|root,COG1807@1|root,COG0463@2|Bacteria,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	MA20_09515	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA,PMT_2
k59_76461_1	7091.BGIBMGA011035-TA	3.78e-42	159.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VNK@33154|Opisthokonta,3CB3V@33208|Metazoa,3DSCG@33213|Bilateria,428FM@6656|Arthropoda,3SSDK@50557|Insecta,44A45@7088|Lepidoptera	33208|Metazoa	L	gag-polypeptide of LTR copia-type	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2
k59_18448_1	570417.WP1038	9.73e-123	358.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,47F3Q@766|Rickettsiales	766|Rickettsiales	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_268892_1	555778.Hneap_0412	9.79e-135	396.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1X26N@135613|Chromatiales	135613|Chromatiales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
k59_59067_1	1380394.JADL01000001_gene2929	2.21e-101	308.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales	204441|Rhodospirillales	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
k59_89548_1	436308.Nmar_0651	9.83e-49	178.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k59_246289_1	7029.ACYPI008531-PA	3.85e-152	489.0	COG2801@1|root,KOG3510@1|root,KOG0017@2759|Eukaryota,KOG3510@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EBZ8@33342|Paraneoptera	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_236112_1	570417.WP1357	2.05e-113	333.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,47F0C@766|Rickettsiales	766|Rickettsiales	M	Belongs to the peptidase S11 family	dacA	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
k59_18454_1	1163617.SCD_n02290	1.89e-124	397.0	COG3437@1|root,COG3829@1|root,COG4191@1|root,COG5001@1|root,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg
k59_49385_1	1131266.ARWQ01000004_gene1457	1.44e-14	72.8	COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota	651137|Thaumarchaeota	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_49385_2	436308.Nmar_1294	4.99e-31	108.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
k59_49385_3	1229909.NSED_07185	6.38e-69	215.0	COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
k59_228321_1	1232437.KL662047_gene5175	1.9e-37	131.0	COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,42U3P@68525|delta/epsilon subdivisions,2WPN5@28221|Deltaproteobacteria,2MNEN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_228321_2	3055.EDP02818	1.56e-05	50.8	COG5354@1|root,KOG2315@2759|Eukaryota,37J2H@33090|Viridiplantae,34GQS@3041|Chlorophyta	3041|Chlorophyta	J	eukaryotic translation initiation factor	-	-	-	ko:K15026	-	-	-	-	ko00000,ko03012,ko03019	-	-	-	eIF2A
k59_148187_1	1523503.JPMY01000002_gene3794	5.97e-45	167.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_286964_1	1229909.NSED_08310	2.66e-15	77.4	COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_286964_2	1229909.NSED_08305	1.22e-33	117.0	arCOG01354@1|root,arCOG01354@2157|Archaea,41T7T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transcription factor Pcc1	-	-	-	-	-	-	-	-	-	-	-	-	Pcc1
k59_286964_3	1229909.NSED_08300	1.05e-29	116.0	COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
k59_169442_1	477184.KYC_23768	1.18e-92	288.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2VIYX@28216|Betaproteobacteria,3T1UQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	-	1.8.1.2,1.8.7.1	ko:K00381,ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858,R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k59_198619_1	570417.WP0619	3.77e-153	442.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,47F3U@766|Rickettsiales	766|Rickettsiales	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
k59_7893_1	883080.HMPREF9697_02657	1.46e-58	191.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TUVG@28211|Alphaproteobacteria,3JTCJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_258057_1	7176.CPIJ005440-PA	3.63e-39	149.0	KOG1871@1|root,KOG1871@2759|Eukaryota,38D2C@33154|Opisthokonta,3BE30@33208|Metazoa,3CUMU@33213|Bilateria,41XDE@6656|Arthropoda,3SJER@50557|Insecta,44ZGI@7147|Diptera,45BYC@7148|Nematocera	33208|Metazoa	O	Belongs to the peptidase C19 family	USP10	GO:0000731,GO:0002039,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004843,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006464,GO:0006508,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008593,GO:0009058,GO:0009059,GO:0009894,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010506,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0016579,GO:0016787,GO:0018130,GO:0019222,GO:0019438,GO:0019538,GO:0019783,GO:0019985,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030330,GO:0031323,GO:0031329,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032991,GO:0033554,GO:0034097,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0036211,GO:0036459,GO:0042221,GO:0042770,GO:0043122,GO:0043124,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044325,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045747,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070555,GO:0070646,GO:0070647,GO:0070887,GO:0071310,GO:0071345,GO:0071347,GO:0071704,GO:0071897,GO:0072331,GO:0090304,GO:0097708,GO:0101005,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1902531,GO:1902532	3.4.19.12	ko:K11841,ko:K13958	ko04139,map04139	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04121	-	-	-	PAM2,UCH
k59_89586_1	397945.Aave_3965	8.09e-95	293.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_317139_1	436308.Nmar_0926	2.5e-75	244.0	COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
k59_89596_1	1828.JOKB01000009_gene5380	6.8e-54	181.0	COG0715@1|root,COG0715@2|Bacteria,2IEVS@201174|Actinobacteria,4G66Z@85025|Nocardiaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_157499_1	7029.ACYPI066973-PA	9.37e-23	102.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3DE2J@33213|Bilateria	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_207941_2	570417.WP0044	2.9e-23	92.8	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,LRR_6
k59_107106_1	1236908.wNo_02720	1.86e-11	62.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,47F4C@766|Rickettsiales	766|Rickettsiales	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
k59_107106_2	1236908.wNo_02730	4.17e-99	298.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,47F36@766|Rickettsiales	766|Rickettsiales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k59_18495_1	1229909.NSED_09905	8.89e-57	196.0	COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
k59_28538_1	1236908.wNo_04900	1.54e-144	409.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,47F6A@766|Rickettsiales	766|Rickettsiales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
k59_117964_1	163164.WD_0549	3.07e-154	458.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,47EYC@766|Rickettsiales	766|Rickettsiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_89599_2	1131266.ARWQ01000006_gene262	2.04e-54	173.0	arCOG08654@1|root,arCOG08654@2157|Archaea,41SRM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_207943_1	1196031.ALEG01000055_gene4460	2.02e-26	109.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HEIB@91061|Bacilli,1ZEZ9@1386|Bacillus	91061|Bacilli	L	COG3344 Retron-type reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_194268_1	7029.ACYPI004323-PA	5.23e-41	155.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_4229_1	1158601.I585_00916	1.05e-09	69.3	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1TPFZ@1239|Firmicutes,4HAIF@91061|Bacilli,4B001@81852|Enterococcaceae	91061|Bacilli	KL	Bacterial SNF2 helicase associated	snf	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
k59_85054_1	195250.CM001776_gene2872	2.76e-74	237.0	2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria	1117|Cyanobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_64916_1	2340.JV46_05690	1.29e-131	382.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_144276_1	1236908.wNo_01340	5.49e-148	425.0	COG0358@1|root,COG3598@1|root,COG0358@2|Bacteria,COG3598@2|Bacteria	2|Bacteria	L	Psort location Cytoplasmic, score	-	-	3.6.4.12	ko:K17680	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	AAA_25,DUF3987,DnaB_C,Toprim_2,Toprim_4
k59_54683_1	7425.NV30389-PA	8.41e-22	92.4	2F3G8@1|root,2T4FJ@2759|Eukaryota,38Y72@33154|Opisthokonta,3C5TK@33208|Metazoa,3DM4J@33213|Bilateria,42320@6656|Arthropoda	7425.NV30389-PA|-	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_194291_1	1500259.JQLD01000002_gene2945	2.17e-08	57.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,4BH56@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
k59_194291_2	1297865.APJD01000005_gene3986	4.74e-19	89.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TS4B@28211|Alphaproteobacteria,3JW7D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k59_45037_1	7070.TC004098-PA	5.42e-38	147.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_34993_1	7230.FBpp0171079	1.33e-22	101.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_214213_1	1267533.KB906737_gene1954	2.06e-34	135.0	COG3378@1|root,COG5545@1|root,COG3378@2|Bacteria,COG5545@2|Bacteria,3Y8ED@57723|Acidobacteria,2JNMH@204432|Acidobacteriia	204432|Acidobacteriia	S	D5 N terminal like	-	-	-	-	-	-	-	-	-	-	-	-	D5_N
k59_85085_1	436308.Nmar_1754	2.77e-40	145.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
k59_85085_2	1229909.NSED_09335	8.41e-44	155.0	arCOG08764@1|root,arCOG08764@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_134944_1	257313.BP3648	1.15e-94	285.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,3T1D9@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k59_264316_1	883080.HMPREF9697_01680	8.91e-157	449.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,3JS55@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_194306_1	1163617.SCD_n02941	1.16e-137	400.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_95152_1	570417.WP1271	1.2e-166	482.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2U258@28211|Alphaproteobacteria,47F16@766|Rickettsiales	766|Rickettsiales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_95152_2	570417.WP1270	1.11e-99	290.0	COG1076@1|root,COG1076@2|Bacteria	2|Bacteria	O	ATPase activator activity	hscB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234	-	ko:K04082,ko:K05801	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C,TerB
k59_95152_3	1236908.wNo_10830	1.58e-59	184.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,47FGE@766|Rickettsiales	766|Rickettsiales	S	Belongs to the HesB IscA family	iscA2	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
k59_64967_2	436308.Nmar_0036	6.79e-24	91.7	arCOG08815@1|root,arCOG08815@2157|Archaea,41T9N@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_24482_1	1121422.AUMW01000029_gene16	4.44e-50	179.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
k59_223913_1	1280696.ATVY01000069_gene1798	1.46e-09	62.8	COG0730@1|root,COG0730@2|Bacteria,1V32T@1239|Firmicutes,24GGU@186801|Clostridia,4BYVX@830|Butyrivibrio	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_54689_3	292564.Cyagr_0388	5.16e-16	82.8	COG4678@1|root,COG4678@2|Bacteria,1GE65@1117|Cyanobacteria,22SQJ@167375|Cyanobium	1117|Cyanobacteria	G	Muramidase (Phage lambda lysozyme)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_73452_2	1158182.KB905023_gene1456	0.000414	45.4	COG4970@1|root,COG4970@2|Bacteria,1NE3U@1224|Proteobacteria,1SX63@1236|Gammaproteobacteria,1WZS3@135613|Chromatiales	135613|Chromatiales	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
k59_303146_1	570417.WP1121	2.41e-126	379.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,47F1H@766|Rickettsiales	766|Rickettsiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_194331_1	1123242.JH636435_gene2670	9.75e-26	110.0	COG3210@1|root,COG3468@1|root,COG3210@2|Bacteria,COG3468@2|Bacteria	2|Bacteria	MU	cell adhesion	pic	GO:0005575,GO:0005576,GO:0005623,GO:0009986,GO:0044464	-	ko:K03117,ko:K12287,ko:K12684,ko:K15125,ko:K19231	ko03060,ko03070,ko05133,map03060,map03070,map05133	M00336	-	-	ko00000,ko00001,ko00002,ko00536,ko01000,ko02000,ko02044	1.B.12,1.B.12.4,2.A.64	-	-	Autotransporter,Haemagg_act,Peptidase_S6
k59_233114_1	570417.WP0196	4.82e-182	513.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,47EWR@766|Rickettsiales	766|Rickettsiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k59_4284_1	27923.ML12866a-PA	4.67e-28	119.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_85138_1	436308.Nmar_0306	1.64e-49	164.0	COG0500@1|root,arCOG01631@2157|Archaea,41SJC@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	DOT1
k59_85138_2	436308.Nmar_0305	2.8e-55	174.0	arCOG08781@1|root,arCOG08781@2157|Archaea,41SVY@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_65002_1	1163617.SCD_n00618	6.91e-150	459.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_14517_1	570417.WP1258	1.04e-112	330.0	COG0630@1|root,COG0630@2|Bacteria,1QUJ6@1224|Proteobacteria,2TW2D@28211|Alphaproteobacteria,47EXK@766|Rickettsiales	766|Rickettsiales	NU	Type IV secretory pathway, VirB11 components, and related ATPases involved in	virB11	-	-	ko:K03196	ko03070,ko05120,map03070,map05120	M00333,M00564	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T2SSE
k59_114286_1	7070.TC001899-PA	3.92e-60	214.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SQXX@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_184586_2	1236908.wNo_03670	8.71e-69	211.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	3-5 exonuclease	rnd1	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
k59_223942_1	7213.XP_004520233.1	1.12e-45	171.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_214269_1	1236908.wNo_09150	3.05e-144	418.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4
k59_283531_1	1410619.SRDD_34000	2.3e-54	182.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,4036M@613|Serratia	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_35075_1	1131266.ARWQ01000017_gene888	5.05e-61	201.0	COG0043@1|root,arCOG01671@2157|Archaea,41S94@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_184596_1	1996.JOFO01000007_gene4631	3.47e-18	80.5	COG1720@1|root,COG1720@2|Bacteria,2IKKT@201174|Actinobacteria,4EJX7@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
k59_184596_2	1040983.AXAE01000004_gene765	1.19e-13	72.8	COG0500@1|root,COG2226@2|Bacteria,1R6ZI@1224|Proteobacteria,2TRC6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_294093_1	1236908.wNo_09140	2.01e-89	293.0	COG1672@1|root,COG5539@1|root,COG1672@2|Bacteria,COG5539@2|Bacteria	2|Bacteria	O	protein K27-linked deubiquitination	-	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0036210,GO:0036211,GO:0043087,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044033,GO:0044238,GO:0046872,GO:0050568,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009,GO:0071704,GO:0140096,GO:1901564	-	ko:K06921,ko:K15354	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	AAA_16,KAP_NTPase,Mrr_cat,NACHT,SIR2_2,Tox-PLDMTX
k59_85161_1	570417.WP0166	1.9e-131	382.0	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,47F2V@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_313348_1	436308.Nmar_0829	1.84e-86	262.0	COG1651@1|root,arCOG02868@2157|Archaea,41T2A@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_223960_1	67267.JNXT01000065_gene528	3.2e-22	99.8	COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_264393_1	7425.NV19076-PA	3.83e-77	258.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,41Y67@6656|Arthropoda,3SGFP@50557|Insecta,46MMY@7399|Hymenoptera	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve,zf-H2C2
k59_65044_1	1528106.JRJE01000009_gene1753	4e-97	291.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2JQUY@204441|Rhodospirillales	204441|Rhodospirillales	S	transport system periplasmic component	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_24534_1	436308.Nmar_1243	2.66e-45	160.0	COG0433@1|root,arCOG00280@2157|Archaea,41SE3@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
k59_24534_2	1229909.NSED_06980	5.92e-47	160.0	COG0420@1|root,arCOG00397@2157|Archaea,41S68@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos_2
k59_95240_4	443143.GM18_2184	5.48e-05	44.7	2DA0E@1|root,32TUD@2|Bacteria,1QXP4@1224|Proteobacteria,430AH@68525|delta/epsilon subdivisions,2WVN8@28221|Deltaproteobacteria,43VAX@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_174441_1	570417.WP0976	1.39e-263	726.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U28T@28211|Alphaproteobacteria,47F3F@766|Rickettsiales	766|Rickettsiales	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_164899_1	570417.WP0889	2.51e-202	569.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,47EV6@766|Rickettsiales	766|Rickettsiales	I	propionyl-CoA carboxylase beta	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_194396_1	76114.ebA1623	2.93e-22	92.8	COG3510@1|root,COG3510@2|Bacteria,1MWJ8@1224|Proteobacteria,2WA6U@28216|Betaproteobacteria,2KZJY@206389|Rhodocyclales	206389|Rhodocyclales	V	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	CmcI
k59_264399_1	570417.WP1035	9.72e-58	181.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,47FD7@766|Rickettsiales	766|Rickettsiales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
k59_313367_1	570417.WP0627	1.98e-146	441.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,47EW6@766|Rickettsiales	766|Rickettsiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_114326_1	391625.PPSIR1_20234	1.82e-119	363.0	COG3385@1|root,COG3385@2|Bacteria,1QZNB@1224|Proteobacteria,43CM4@68525|delta/epsilon subdivisions,2X7VR@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_136161_1	580332.Slit_2335	2e-96	296.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,2WB3N@28216|Betaproteobacteria,44WNP@713636|Nitrosomonadales	28216|Betaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_255107_1	292415.Tbd_2319	4.18e-88	290.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC	-	-	ko:K03296,ko:K07788,ko:K07789,ko:K21133	ko02020,map02020	M00648,M00822	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2,2.A.6.2.35	-	-	ACR_tran
k59_115099_1	570417.WP0569	1.07e-122	360.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,47F6I@766|Rickettsiales	766|Rickettsiales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
k59_154789_1	1236908.wNo_02000	3.95e-83	253.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2TU7N@28211|Alphaproteobacteria,47F5H@766|Rickettsiales	766|Rickettsiales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	sam	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
k59_265387_1	1004785.AMBLS11_12625	2.15e-08	61.2	COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,VWA_2
k59_175382_1	1173263.Syn7502_02730	2.54e-69	219.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
k59_104566_1	1095769.CAHF01000011_gene2091	5.8e-05	44.3	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2VIKG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	fad dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
k59_264823_1	29581.BW37_01026	2.4e-41	143.0	COG3495@1|root,COG3495@2|Bacteria,1RFBI@1224|Proteobacteria,2VRJ9@28216|Betaproteobacteria,477HV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3299)	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
k59_55242_1	1236908.wNo_10520	5.42e-149	421.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,47FB2@766|Rickettsiales	766|Rickettsiales	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
k59_65606_1	1131266.ARWQ01000004_gene1415	1.74e-114	349.0	COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_264826_1	330214.NIDE2561	8.43e-109	327.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_104096_1	1047013.AQSP01000122_gene2227	3.23e-26	102.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	GerE,Response_reg,TauD
k59_104096_2	944435.AXAJ01000001_gene300	1.25e-10	60.8	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VME6@28216|Betaproteobacteria,1K3H4@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
k59_25033_1	522306.CAP2UW1_0003	2.28e-99	314.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1KPTZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_65612_1	330214.NIDE1277	4.83e-92	284.0	COG3225@1|root,COG3225@2|Bacteria	2|Bacteria	-	-	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
k59_233488_1	7070.TC004227-PA	1.87e-114	380.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_14994_1	1454004.AW11_00950	6.56e-75	231.0	COG0664@1|root,COG0664@2|Bacteria,1RAF3@1224|Proteobacteria,2VQIC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
k59_214726_1	1229909.NSED_04950	7.53e-116	343.0	COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
k59_35524_1	420324.KI912025_gene48	2.17e-71	223.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria,1JTK7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS4 family protein	tnp*	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_104106_1	1165096.ARWF01000001_gene1565	2.34e-17	82.8	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KKJ9@206350|Nitrosomonadales	206350|Nitrosomonadales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
k59_104106_2	1003200.AXXA_10490	7.38e-06	43.5	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
k59_313759_1	580332.Slit_0534	5.22e-08	52.8	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,44W4T@713636|Nitrosomonadales	28216|Betaproteobacteria	S	SMART beta-lactamase domain protein	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
k59_313759_2	1000565.METUNv1_02454	5.64e-41	152.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales	206389|Rhodocyclales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
k59_95780_1	570417.WP0636	2.63e-298	829.0	COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,47F23@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	virB4-2	-	-	ko:K03199	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagE_TrbE_VirB
k59_154313_1	1173023.KE650771_gene5548	5.1e-29	111.0	COG3385@1|root,COG3385@2|Bacteria,1G2W3@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_55270_1	262543.Exig_0338	4.59e-11	68.9	COG0668@1|root,COG0668@2|Bacteria,1TQXJ@1239|Firmicutes,4HCK2@91061|Bacilli	91061|Bacilli	M	Conserved TM helix	ygxB	-	-	-	-	-	-	-	-	-	-	-	TM_helix
k59_224518_1	570417.WP0741	8.98e-147	435.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,47EWT@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k59_303592_1	436308.Nmar_1577	5.35e-44	161.0	COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota	651137|Thaumarchaeota	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
k59_294604_1	570417.WP1274	1.98e-63	202.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,47F43@766|Rickettsiales	766|Rickettsiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
k59_294604_2	570417.WP1275	3.41e-31	119.0	COG0666@1|root,COG0666@2|Bacteria,1NNGE@1224|Proteobacteria	1224|Proteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_73865_1	1007103.AFHW01000013_gene6178	8.44e-79	251.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,4HDSE@91061|Bacilli,26V76@186822|Paenibacillaceae	91061|Bacilli	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_165447_1	889378.Spiaf_1668	1.95e-13	68.6	COG2201@1|root,COG2201@2|Bacteria,2J7EW@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	cheY-3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
k59_165447_2	436308.Nmar_0189	1.13e-26	109.0	COG0642@1|root,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k59_284009_1	1236908.wNo_09760	2.09e-71	224.0	COG1757@1|root,COG1757@2|Bacteria,1MX0T@1224|Proteobacteria,2UNJJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_284009_2	570417.WP1351	4.84e-05	44.3	COG0484@1|root,COG0666@1|root,COG0484@2|Bacteria,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	anK3	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Ank_2,Ank_4,DUF3099,DnaJ
k59_313790_1	436308.Nmar_0578	5.11e-101	307.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
k59_194894_1	7029.ACYPI38899-PA	4.26e-16	84.3	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_275760_3	436308.Nmar_1603	3.26e-12	63.9	COG1370@1|root,arCOG00991@2157|Archaea,41SP1@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Patch-forming domain C2 of tRNA-guanine transglycosylase	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
k59_255583_1	570417.WP0150	3.13e-117	341.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,47EZ4@766|Rickettsiales	766|Rickettsiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_136758_1	570417.WP0387	1.28e-125	373.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,47EWW@766|Rickettsiales	766|Rickettsiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_155242_1	324925.Ppha_2593	2.34e-147	433.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_5665_1	1288494.EBAPG3_21580	8.28e-99	299.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2VIRC@28216|Betaproteobacteria,3722W@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,SGL
k59_56457_1	1123354.AUDR01000016_gene1305	1.18e-12	66.6	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,1KRJ9@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome C1 family	-	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_56457_2	323848.Nmul_A1002	5.21e-72	220.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,372NI@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Glutathione S-transferase, N-terminal domain	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N,GST_N_3
k59_265993_1	1236908.wNo_03590	2.38e-70	212.0	COG1324@1|root,COG1324@2|Bacteria	2|Bacteria	P	tolerance protein	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840	4.2.3.1	ko:K01733,ko:K03926	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	CutA1
k59_175876_1	1318628.MARLIPOL_07224	7.55e-15	80.1	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,465V0@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235,RHS,RHS_repeat
k59_255599_1	37682.EMT25146	4.43e-14	70.5	2C3SF@1|root,2S2UC@2759|Eukaryota,37VV6@33090|Viridiplantae,3GJGF@35493|Streptophyta	35493|Streptophyta	S	protein Sb1514s002020 source	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_255599_3	6669.EFX62987	2.23e-13	65.9	2BG5J@1|root,2S18N@2759|Eukaryota,3A435@33154|Opisthokonta,3BRGG@33208|Metazoa,3D9S5@33213|Bilateria,420N2@6656|Arthropoda	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_266021_1	298655.KI912266_gene6187	2.25e-57	197.0	COG0469@1|root,COG0469@2|Bacteria,2H57R@201174|Actinobacteria	201174|Actinobacteria	G	Pyruvate kinase	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
k59_125675_1	7159.AAEL004380-PA	2.57e-41	144.0	2D4C1@1|root,2SUMW@2759|Eukaryota,3AR2X@33154|Opisthokonta,3C2QG@33208|Metazoa,3DSTQ@33213|Bilateria,428WK@6656|Arthropoda,3SYD8@50557|Insecta,45AVA@7147|Diptera,45KST@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_104992_1	570417.WP0743	1.33e-31	116.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03286,ko:K10936	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.6	-	-	OMP_b-brl
k59_104992_2	570417.WP0744	4.31e-53	174.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,47EXQ@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
k59_266032_1	7230.FBpp0160046	0.000745	45.1	2EZ1S@1|root,2T0FK@2759|Eukaryota,3AVPW@33154|Opisthokonta,3C493@33208|Metazoa,3DJIX@33213|Bilateria,423UQ@6656|Arthropoda,3SRK3@50557|Insecta,4579X@7147|Diptera,45WFJ@7214|Drosophilidae	33208|Metazoa	S	FLYWCH zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4806,FLYWCH
k59_215861_1	7955.ENSDARP00000106282	1.35e-75	266.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_136816_1	1210884.HG799467_gene13396	3.49e-122	359.0	2DBFF@1|root,2Z8YA@2|Bacteria	2|Bacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
k59_234289_1	626887.J057_07101	2.88e-65	213.0	COG0591@1|root,COG0591@2|Bacteria,1PKDE@1224|Proteobacteria,1RP4J@1236|Gammaproteobacteria,46AUG@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
k59_314743_2	330214.NIDE2650	3.28e-21	91.7	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	cnpD3	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,HD_5
k59_36696_1	1236908.wNo_02970	3.69e-134	409.0	COG3704@1|root,COG3704@2|Bacteria,1P5RF@1224|Proteobacteria	1224|Proteobacteria	U	Conjugal transfer protein	virB6	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_56514_1	102107.XP_008223780.1	4.44e-49	179.0	COG2801@1|root,KOG1192@1|root,KOG0017@2759|Eukaryota,KOG1192@2759|Eukaryota	2759|Eukaryota	G	transferase activity, transferring hexosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
k59_5712_1	1236908.wNo_00140	1.08e-32	115.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,47FMZ@766|Rickettsiales	766|Rickettsiales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
k59_182610_1	7029.ACYPI52857-PA	1.35e-52	193.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_281922_1	436308.Nmar_0108	4.36e-42	140.0	COG1324@1|root,arCOG04231@2157|Archaea,41SR4@651137|Thaumarchaeota	651137|Thaumarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
k59_192587_1	1229909.NSED_03180	2.66e-102	319.0	COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_93119_1	760192.Halhy_2258	2.14e-38	138.0	COG1484@1|root,COG1484@2|Bacteria,4NFE0@976|Bacteroidetes,1IP5Q@117747|Sphingobacteriia	976|Bacteroidetes	L	PFAM IstB-like ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_311742_1	1155714.KB891998_gene1232	5.02e-73	237.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
k59_62766_1	1236908.wNo_02680	1.21e-204	566.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,47FB8@766|Rickettsiales	766|Rickettsiales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31,Methyltransf_4
k59_182625_1	436308.Nmar_0554	2.08e-148	426.0	COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_142603_1	7029.ACYPI35092-PA	2.58e-61	209.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VJ1@33154|Opisthokonta,3CB3U@33208|Metazoa,3DT1J@33213|Bilateria,4294G@6656|Arthropoda,3SW1M@50557|Insecta,3EE1Z@33342|Paraneoptera	7029.ACYPI35092-PA|-	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_202525_1	1229909.NSED_08945	8.97e-16	80.5	COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota	651137|Thaumarchaeota	V	resistance protein	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
k59_202525_2	1229909.NSED_08970	1.09e-12	68.2	arCOG08812@1|root,arCOG08812@2157|Archaea,41T50@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_2708_1	7070.TC004224-PA	7.07e-54	189.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_172673_1	999541.bgla_1g22660	1.55e-72	224.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,1K2WG@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_292282_1	7029.ACYPI000268-PA	2.73e-40	151.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_222311_1	7425.NV18974-PA	2.85e-39	149.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,427KC@6656|Arthropoda,3SQHX@50557|Insecta	33208|Metazoa	L	Pfam:UBN2	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_43187_1	330214.NIDE0370	5.76e-104	314.0	COG0056@1|root,COG0056@2|Bacteria,3J0CZ@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k59_142630_1	7029.ACYPI56748-PA	1.3e-39	150.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3DDWX@33213|Bilateria,42228@6656|Arthropoda,3SPN5@50557|Insecta,3ED9B@33342|Paraneoptera	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVP,RVT_1,Retrotrans_gag,rve,zf-CCHC
k59_22864_1	1236908.wNo_11150	1.94e-130	396.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,47F0W@766|Rickettsiales	766|Rickettsiales	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
k59_22864_2	570417.WP0218	2.07e-64	204.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	2.8.1.1,2.8.1.2	ko:K01011,ko:K06867	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Ank,Ank_2,Ank_4,Ank_5,Rhodanese
k59_93171_1	570417.WP1038	6.84e-131	379.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,47F3Q@766|Rickettsiales	766|Rickettsiales	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
k59_2711_1	1266925.JHVX01000006_gene2084	1.11e-69	233.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k59_133039_1	69319.XP_008546603.1	5.17e-20	92.8	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_134343_1	1229909.NSED_00950	1.39e-73	222.0	COG1358@1|root,arCOG01751@2157|Archaea,41SMS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
k59_134343_2	1131266.ARWQ01000008_gene311	4.21e-30	107.0	COG2053@1|root,arCOG04314@2157|Archaea,41ST6@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
k59_134343_3	1229909.NSED_00960	3.12e-39	130.0	COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
k59_134343_4	1229909.NSED_00965	9.21e-15	69.3	COG0105@1|root,arCOG04313@2157|Archaea,41SN1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_13964_1	748247.AZKH_4372	3.06e-52	186.0	COG3637@1|root,COG3637@2|Bacteria,1R42W@1224|Proteobacteria,2WHYH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
k59_34427_1	1459636.NTE_03164	4.73e-91	268.0	COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM 4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_312779_1	1156919.QWC_27481	5.33e-59	189.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,3T4G8@506|Alcaligenaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k59_273656_1	1229909.NSED_07845	6.36e-65	206.0	COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
k59_23975_1	570417.WP0627	3.26e-193	564.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,47EW6@766|Rickettsiales	766|Rickettsiales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_3755_1	436308.Nmar_0385	2.14e-78	236.0	COG0080@1|root,arCOG04372@2157|Archaea,41SJW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_3755_2	436308.Nmar_0383	1.81e-17	76.6	COG1522@1|root,arCOG01580@2157|Archaea,41SJD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
k59_103182_1	318424.EU78_28035	2.77e-08	57.0	COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,238Q9@1762|Mycobacteriaceae	201174|Actinobacteria	P	Zinc permease	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
k59_164244_1	189753.AXAS01000058_gene148	5.26e-53	182.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,3JW5G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_13982_1	7159.AAEL017470-PA	3.13e-29	120.0	COG0515@1|root,KOG1152@2759|Eukaryota,38BA6@33154|Opisthokonta,3BC21@33208|Metazoa,3CVIZ@33213|Bilateria,41VZ3@6656|Arthropoda,3SKMJ@50557|Insecta,44ZXN@7147|Diptera,45CCP@7148|Nematocera	33208|Metazoa	T	Serine/Threonine protein kinases, catalytic domain	PASK	GO:0002791,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006417,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010675,GO:0010677,GO:0010817,GO:0010906,GO:0010962,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019222,GO:0019538,GO:0023051,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032270,GO:0032501,GO:0032879,GO:0032881,GO:0032885,GO:0034248,GO:0034250,GO:0035091,GO:0036211,GO:0042592,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043255,GO:0043412,GO:0043467,GO:0043576,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045727,GO:0045912,GO:0046777,GO:0046883,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048871,GO:0050789,GO:0050794,GO:0051046,GO:0051049,GO:0051171,GO:0051173,GO:0051239,GO:0051246,GO:0051247,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070092,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090087,GO:0090276,GO:0097009,GO:0140096,GO:1901564,GO:1903530,GO:2000112,GO:2000113	2.7.11.1	ko:K08801	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PAS_9,Pkinase
k59_34433_1	7176.CPIJ000938-PA	6.94e-31	117.0	KOG2579@1|root,KOG2579@2759|Eukaryota,38H7K@33154|Opisthokonta,3BHN9@33208|Metazoa,3DGP2@33213|Bilateria,41TX5@6656|Arthropoda,3SMB3@50557|Insecta,4539I@7147|Diptera,45HTQ@7148|Nematocera	33208|Metazoa	S	Fibrinogen-related domains (FReDs)	-	-	-	-	-	-	-	-	-	-	-	-	Fibrinogen_C
k59_84532_1	266265.Bxe_C0691	4.91e-74	237.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,1K2CQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k59_203718_1	7029.ACYPI081863-PA	2.84e-70	243.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_34435_1	10224.XP_006825930.1	2.12e-18	92.4	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_123776_1	296591.Bpro_2848	5.04e-53	178.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHC7@28216|Betaproteobacteria,4AC92@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k59_134386_1	1229909.NSED_09155	1.62e-92	277.0	COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
k59_183971_1	1561998.Csp11.Scaffold300.g784.t1	7.04e-60	222.0	COG2801@1|root,KOG0017@2759|Eukaryota,3A08P@33154|Opisthokonta,3BPIW@33208|Metazoa,3CTR8@33213|Bilateria,40GTB@6231|Nematoda,1KZN8@119089|Chromadorea,40XT8@6236|Rhabditida	33208|Metazoa	L	transposition, RNA-mediated	RTL1	-	2.7.1.147	ko:K08074	ko00010,ko01100,ko01110,ko01130,ko01200,map00010,map01100,map01110,map01130,map01200	M00001	R05804,R09085,R09086	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_protease_2,DUF4939,RVP_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_293522_1	436308.Nmar_0027	1.03e-40	140.0	arCOG08814@1|root,arCOG08814@2157|Archaea,41T9Z@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_293522_2	1131266.ARWQ01000001_gene1340	4.58e-11	61.6	COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_223401_1	7159.AAEL005015-PA	1.89e-78	261.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VPS@33154|Opisthokonta,3C5ZM@33208|Metazoa,3DM1B@33213|Bilateria,42CJJ@6656|Arthropoda,3STFX@50557|Insecta,4582J@7147|Diptera,45M6U@7148|Nematocera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_34460_1	7425.NV18508-PA	5.06e-41	153.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_232706_1	375286.mma_0819	2.67e-72	227.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2VNS2@28216|Betaproteobacteria,476I4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
k59_273710_1	7029.ACYPI008531-PA	5.51e-49	177.0	COG2801@1|root,KOG3510@1|root,KOG0017@2759|Eukaryota,KOG3510@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EBZ8@33342|Paraneoptera	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_312832_1	436308.Nmar_1289	2.19e-51	171.0	COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_312832_2	1131266.ARWQ01000004_gene1454	4.37e-57	184.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
k59_312834_1	330214.NIDE0726	1.08e-77	257.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k59_242620_1	388051.AUFE01000056_gene4844	2.24e-49	169.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
k59_273722_1	330214.NIDE0511	2.79e-84	254.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
k59_103250_1	640081.Dsui_1455	1.55e-64	218.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales	206389|Rhodocyclales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	-	-	-	-	-	-	-	-	-	GAF,T2SSE,T2SSE_N
k59_213696_1	426355.Mrad2831_6137	1.62e-25	100.0	COG3293@1|root,COG3293@2|Bacteria,1REVC@1224|Proteobacteria,2U6ZB@28211|Alphaproteobacteria,1JW8N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
k59_213696_2	1340493.JNIF01000003_gene1612	1.16e-37	129.0	COG3293@1|root,COG3293@2|Bacteria,3Y7X8@57723|Acidobacteria	57723|Acidobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
k59_153390_1	436308.Nmar_1705	1.42e-114	332.0	COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_232731_1	1229909.NSED_03415	1.03e-09	59.7	arCOG03053@1|root,arCOG03053@2157|Archaea	2157|Archaea	H	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_34493_1	7029.ACYPI068208-PA	2.31e-71	239.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_263763_1	1236908.wNo_02880	7.9e-52	181.0	2DJHP@1|root,30663@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_263763_2	570417.WP0588	1.14e-109	315.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,47F8V@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
k59_84614_2	1236908.wNo_07880	1.7e-62	197.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,47F6W@766|Rickettsiales	766|Rickettsiales	L	Exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_164337_2	7029.ACYPI25723-PA	5.71e-16	80.9	2DYFQ@1|root,2S6UQ@2759|Eukaryota,3AHW9@33154|Opisthokonta,3BYZJ@33208|Metazoa,3DFS7@33213|Bilateria,42AQ7@6656|Arthropoda,3SQCK@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_54193_1	1459636.NTE_00846	1.09e-33	127.0	COG1994@1|root,COG3582@1|root,arCOG00614@2157|Archaea,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
k59_84615_1	1229205.BUPH_08540	1.96e-85	262.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VP9S@28216|Betaproteobacteria,1K0PK@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
k59_193894_1	7029.ACYPI53110-PA	1.25e-42	160.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_253593_1	7668.SPU_009524-tr	9.59e-25	108.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria	33208|Metazoa	G	K02A2.6-like	-	-	-	ko:K14965	-	-	-	-	ko00000,ko03036	-	-	-	RVT_1,rve
k59_242654_1	13735.ENSPSIP00000000767	5.42e-52	190.0	COG2801@1|root,KOG1721@1|root,KOG0017@2759|Eukaryota,KOG1721@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,48B0V@7711|Chordata,499U9@7742|Vertebrata,4CK8P@8459|Testudines	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,rve,zf-CCHC,zf-H2C2
k59_76631_1	1236908.wNo_05930	1.83e-32	121.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,47F39@766|Rickettsiales	766|Rickettsiales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_76631_2	570417.WP0933	3.33e-70	216.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,47F52@766|Rickettsiales	766|Rickettsiales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
k59_157609_1	436308.Nmar_1004	9.38e-68	223.0	COG0405@1|root,arCOG04053@2157|Archaea	2157|Archaea	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_228489_3	1121382.JQKG01000001_gene2517	1.33e-65	222.0	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria	2|Bacteria	K	chromosome segregation	terL	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k59_18629_1	1163409.UUA_18624	5.01e-13	65.9	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_18629_2	713586.KB900536_gene890	1.25e-108	323.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
k59_148336_1	886377.Murru_1897	3.33e-25	111.0	COG1361@1|root,COG2911@1|root,COG1361@2|Bacteria,COG2911@2|Bacteria,4NG16@976|Bacteroidetes,1HY10@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SdrD_B
k59_258198_1	342610.Patl_3619	5.78e-39	142.0	COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,1S22Y@1236|Gammaproteobacteria,2Q1AT@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
k59_157615_1	1123020.AUIE01000020_gene1054	1.79e-91	278.0	COG3128@1|root,COG3128@2|Bacteria,1MVVI@1224|Proteobacteria,1TBHN@1236|Gammaproteobacteria,1YHMK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3,AhpC-TSA
k59_198779_2	546267.NEIPOLOT_01576	1.18e-30	117.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KPTF@206351|Neisseriales	206351|Neisseriales	C	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
k59_317305_1	522306.CAP2UW1_1881	2.52e-47	163.0	COG3039@1|root,COG3039@2|Bacteria,1MXTN@1224|Proteobacteria,2VQ35@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
k59_157622_1	7668.SPU_004392-tr	2.58e-08	60.1	2D0IG@1|root,2S4TS@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_287096_1	330214.NIDE1223	5.97e-85	264.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_258210_1	7029.ACYPI061330-PA	1.35e-25	110.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_236263_1	867845.KI911784_gene2483	9.96e-72	232.0	COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi,374XP@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM malate synthase A	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k59_269123_1	1131266.ARWQ01000002_gene562	1.37e-81	250.0	COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein L4	-	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_18672_1	43151.ADAC004853-PA	6.38e-33	139.0	COG5100@1|root,KOG2834@2759|Eukaryota,38CMA@33154|Opisthokonta,3BC9K@33208|Metazoa,3CWC1@33213|Bilateria,41WTC@6656|Arthropoda,3SRA1@50557|Insecta,455S5@7147|Diptera,45KGS@7148|Nematocera	33208|Metazoa	UY	NPL4 family	NPLOC4	GO:0000731,GO:0001817,GO:0001818,GO:0002682,GO:0002683,GO:0002697,GO:0002698,GO:0002831,GO:0002832,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006508,GO:0006511,GO:0006515,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006974,GO:0006996,GO:0007030,GO:0007275,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009605,GO:0009607,GO:0009615,GO:0009790,GO:0009792,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0010498,GO:0010646,GO:0010648,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0018130,GO:0019438,GO:0019538,GO:0019899,GO:0019941,GO:0019985,GO:0023051,GO:0023057,GO:0030163,GO:0030433,GO:0030970,GO:0031347,GO:0031348,GO:0031625,GO:0031974,GO:0031981,GO:0031984,GO:0032101,GO:0032102,GO:0032182,GO:0032479,GO:0032480,GO:0032501,GO:0032502,GO:0032527,GO:0032991,GO:0033036,GO:0033554,GO:0034098,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0034976,GO:0035966,GO:0035967,GO:0036501,GO:0036503,GO:0039531,GO:0039532,GO:0039535,GO:0039536,GO:0042175,GO:0042221,GO:0042886,GO:0043130,GO:0043161,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043632,GO:0043900,GO:0043901,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044271,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045088,GO:0045184,GO:0046483,GO:0046907,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048856,GO:0050687,GO:0050688,GO:0050776,GO:0050789,GO:0050794,GO:0050896,GO:0051117,GO:0051179,GO:0051234,GO:0051239,GO:0051241,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051707,GO:0051716,GO:0051788,GO:0065007,GO:0070013,GO:0070727,GO:0070887,GO:0070987,GO:0071218,GO:0071310,GO:0071702,GO:0071704,GO:0071705,GO:0071712,GO:0071840,GO:0071897,GO:0080134,GO:0090304,GO:0098586,GO:0098796,GO:0098827,GO:1901360,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901698,GO:1902531,GO:1902532,GO:1903513	-	ko:K14015	ko04141,map04141	M00400,M00403	-	-	ko00000,ko00001,ko00002	-	-	-	NPL4,UN_NPL4,zf-NPL4
k59_18672_2	570417.WP0269	5.43e-20	83.6	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,47FJ1@766|Rickettsiales	766|Rickettsiales	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_Tnp_IS630
k59_198810_1	1236908.wNo_10330	1.23e-67	206.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
k59_198810_2	1236908.wNo_10340	6.59e-65	198.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
k59_39510_1	1469245.JFBG01000057_gene2374	1.66e-114	337.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales	1236|Gammaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_278548_1	1229909.NSED_08925	2.39e-132	392.0	arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_69693_1	1266925.JHVX01000007_gene2340	6.66e-56	183.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,372KI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
k59_189217_1	7029.ACYPI28832-PA	9.3e-78	267.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_258237_2	7425.NV12855-PA	7.92e-112	389.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,46IFZ@7399|Hymenoptera	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_76694_1	1236908.wNo_05240	2.8e-105	311.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,47FAG@766|Rickettsiales	766|Rickettsiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
k59_76694_2	1236908.wNo_05230	7.12e-20	86.3	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,47F6N@766|Rickettsiales	766|Rickettsiales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_189223_1	570417.WP1059	2.69e-85	251.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,47FV2@766|Rickettsiales	766|Rickettsiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_189223_2	570417.WP1058	1.12e-58	182.0	COG5606@1|root,COG5606@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
k59_49626_1	7070.TC011220-PA	1.22e-245	751.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_258251_1	570417.WP0634	2.46e-155	453.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_8103_1	1229909.NSED_04495	5.44e-112	326.0	COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Proteasome endopeptidase complex	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
k59_287157_1	7029.ACYPI061287-PA	4.34e-14	77.4	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_246547_1	1236908.wNo_00040	7.81e-127	375.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,47EXM@766|Rickettsiales	766|Rickettsiales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_49638_1	1205680.CAKO01000037_gene1313	1.72e-49	174.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
k59_39560_1	330214.NIDE0396	1.52e-19	88.6	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3J136@40117|Nitrospirae	40117|Nitrospirae	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
k59_317397_1	570417.WP0461	2.78e-130	374.0	COG5464@1|root,COG5464@2|Bacteria,1R8FS@1224|Proteobacteria,2UMP3@28211|Alphaproteobacteria,47FF8@766|Rickettsiales	766|Rickettsiales	S	to TIGR01784	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
k59_189254_1	7029.ACYPI062055-PA	2.52e-19	93.2	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3CNH1@33208|Metazoa,3DKAJ@33213|Bilateria,42AEX@6656|Arthropoda,3SZW4@50557|Insecta,3EECK@33342|Paraneoptera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,rve,zf-CCHC
k59_18768_1	163164.WD_0186	1.35e-121	355.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,47FBG@766|Rickettsiales	766|Rickettsiales	J	Ribonuclease D	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_39575_1	436308.Nmar_1693	1.01e-74	243.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_287181_2	583345.Mmol_0633	2.04e-113	335.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KKV0@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k59_228649_1	1236908.wNo_08050	9.17e-83	250.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,47F0J@766|Rickettsiales	766|Rickettsiales	C	COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3	coxC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_228649_2	163164.WD_0142	1.4e-33	119.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,47FFN@766|Rickettsiales	766|Rickettsiales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
k59_306234_1	7176.CPIJ019125-PA	2.03e-20	95.5	COG1131@1|root,KOG0061@2759|Eukaryota,38CVQ@33154|Opisthokonta,3BMMP@33208|Metazoa,3D2T5@33213|Bilateria,41X63@6656|Arthropoda,3SIBB@50557|Insecta,4510V@7147|Diptera,45H0R@7148|Nematocera	33208|Metazoa	Q	ABC-2 type transporter	-	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015248,GO:0015318,GO:0015399,GO:0015405,GO:0015850,GO:0015918,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017127,GO:0022804,GO:0022857,GO:0030301,GO:0031224,GO:0033036,GO:0034040,GO:0034041,GO:0042623,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1901618	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran
k59_8128_1	1236908.wNo_05740	0.0	1322.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,47EW0@766|Rickettsiales	766|Rickettsiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_298501_1	436308.Nmar_1142	1.53e-61	193.0	COG3794@1|root,arCOG02926@2157|Archaea,41SPG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Copper binding proteins, plastocyanin azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
k59_118236_1	1132855.KB913035_gene1703	2.85e-20	90.1	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,2KM6T@206350|Nitrosomonadales	206350|Nitrosomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k59_118236_2	580332.Slit_2067	1.1e-43	152.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,44VKB@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
k59_49680_1	436308.Nmar_0242	3.41e-256	721.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
k59_278646_1	1461577.CCMH01000016_gene276	9.63e-10	62.4	COG1257@1|root,COG1257@2|Bacteria,4NGNG@976|Bacteroidetes,1HY0M@117743|Flavobacteriia	976|Bacteroidetes	I	Belongs to the HMG-CoA reductase family	mvaA	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
k59_278646_2	1229909.NSED_00700	3.58e-82	254.0	COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
k59_236366_1	269796.Rru_A2090	1.02e-43	148.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,2JW3H@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10004	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	ABC_tran
k59_118259_2	272559.BF9343_0223	7.77e-47	152.0	COG0393@1|root,COG0393@2|Bacteria,4NQGB@976|Bacteroidetes,2FT9V@200643|Bacteroidia,4ARBR@815|Bacteroidaceae	976|Bacteroidetes	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
k59_30655_1	1236908.wNo_02900	3.22e-72	227.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,47EYJ@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k59_220094_1	1000565.METUNv1_02260	4.06e-92	289.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,2KUP0@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_110464_1	1397528.Q671_03825	5.5e-67	218.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XNSE@135619|Oceanospirillales	135619|Oceanospirillales	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_70367_1	1380391.JIAS01000018_gene1079	5.67e-83	254.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2JS2T@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k59_140332_1	7029.ACYPI42496-PA	3.51e-30	125.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_90561_1	436308.Nmar_1511	4.03e-75	236.0	COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_250021_1	1469245.JFBG01000016_gene967	1.39e-161	466.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_90574_1	7070.TC011220-PA	8.63e-24	105.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_250025_1	10224.XP_006825930.1	1.23e-47	181.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_20626_1	1131266.ARWQ01000002_gene482	1.83e-116	350.0	COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
k59_210167_1	1192759.AKIB01000028_gene2028	7.88e-23	102.0	COG1572@1|root,COG1864@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG3386@1|root,COG3391@1|root,COG5276@1|root,COG1572@2|Bacteria,COG1864@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2UHRC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FGMQ	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,He_PIG,Laminin_G_3
k59_10687_1	436308.Nmar_1111	1.4e-79	251.0	COG2379@1|root,arCOG04170@2157|Archaea,41SJF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
k59_33222_3	1131266.ARWQ01000001_gene1389	5.26e-19	84.7	COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Tyrosine--tRNA ligase	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
k59_62857_1	1131266.ARWQ01000001_gene1181	2.68e-91	278.0	COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	DBI_PRT
k59_62857_2	1229909.NSED_01550	1.36e-37	131.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k59_2755_1	7425.NV10089-PA	1.04e-18	92.4	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_212516_1	1131553.JIBI01000001_gene1481	8.23e-77	236.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,3726Z@32003|Nitrosomonadales	28216|Betaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
k59_112751_1	436308.Nmar_1359	1.12e-25	103.0	COG0640@1|root,arCOG01686@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_112751_2	436308.Nmar_0252	1.76e-92	275.0	COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Nicotinamide-nucleotide adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_231797_1	8090.ENSORLP00000007670	2.43e-17	86.3	28N8N@1|root,2QUTZ@2759|Eukaryota,39XUZ@33154|Opisthokonta,3BIC8@33208|Metazoa,3D1M8@33213|Bilateria,48DCS@7711|Chordata,49AIX@7742|Vertebrata,4A9GW@7898|Actinopterygii	33208|Metazoa	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_Tnp_Tc3_2
k59_202617_1	7029.ACYPI29951-PA	3.66e-23	104.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_12895_1	521011.Mpal_0200	6.14e-10	63.9	COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota,2N9TG@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
k59_112760_1	7159.AAEL017571-PA	4.19e-13	74.7	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_172751_1	7425.NV17647-PA	4.68e-50	180.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_12896_1	570417.WP0782	1.11e-308	874.0	COG1061@1|root,COG1061@2|Bacteria	2|Bacteria	L	Type III restriction enzyme res subunit	-	GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF3427,DUF3854,Helicase_C,ResIII
k59_152378_1	7425.NV24996-PA	1.12e-50	191.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AV5E@33154|Opisthokonta,3C3DB@33208|Metazoa,3DJZQ@33213|Bilateria	2759|Eukaryota	L	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4283,Exo_endo_phos_2,RNase_H,RVT_1,zf-CCHC_4
k59_262489_1	1007105.PT7_3034	3.14e-35	134.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T1XI@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
k59_262489_2	391038.Bphy_4831	5.29e-18	82.8	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VJWA@28216|Betaproteobacteria,1K5AN@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
k59_33256_1	699218.HMPREF0889_1619	7.15e-05	44.7	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,4H2DA@909932|Negativicutes	909932|Negativicutes	S	TIGR00255 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k59_33256_2	330214.NIDE2460	4.01e-93	279.0	COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae	40117|Nitrospirae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
k59_222405_1	228410.NE1623	2.08e-82	272.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,372NK@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k59_182765_1	1123368.AUIS01000007_gene2785	9.99e-10	58.9	COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,1SJXJ@1236|Gammaproteobacteria,2NC1I@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
k59_182765_2	1123368.AUIS01000007_gene2786	3.54e-79	238.0	COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,1SMDU@1236|Gammaproteobacteria,2NC3A@225057|Acidithiobacillales	225057|Acidithiobacillales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
k59_142745_1	448385.sce7305	1.8e-58	199.0	COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42PWB@68525|delta/epsilon subdivisions,2X5K5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,NTP_transf_3,PEP_mutase
k59_192734_1	1236908.wNo_09450	5.48e-173	492.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,47F12@766|Rickettsiales	766|Rickettsiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
k59_33273_1	570417.WP0356	4.82e-138	429.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,47F1Y@766|Rickettsiales	766|Rickettsiales	E	NAD-specific glutamate dehydrogenase	gdhB	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_282072_1	1236908.wNo_00620	4.22e-14	70.9	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,47EYW@766|Rickettsiales	766|Rickettsiales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_282072_2	570417.WP0050	4.68e-158	443.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,47FIP@766|Rickettsiales	766|Rickettsiales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
k59_192743_1	1262449.CP6013_3029	1.6e-10	65.5	COG0726@1|root,COG0726@2|Bacteria,1V6AW@1239|Firmicutes,24EU8@186801|Clostridia,36EYC@31979|Clostridiaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_62928_1	1411123.JQNH01000001_gene885	2.35e-63	210.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_112803_1	998674.ATTE01000001_gene1965	2.61e-79	251.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1T58V@1236|Gammaproteobacteria,463WP@72273|Thiotrichales	1236|Gammaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_212565_1	986075.CathTA2_0576	1.35e-75	238.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H9X8@91061|Bacilli	91061|Bacilli	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_292416_1	713586.KB900536_gene2525	1.67e-147	424.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_202664_1	1454004.AW11_00314	2.58e-60	209.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,1KPW6@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
k59_12919_1	338969.Rfer_1890	5.57e-63	201.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2WEJG@28216|Betaproteobacteria,4AJ3P@80864|Comamonadaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
k59_142774_1	7070.TC016101-PA	1.9e-40	152.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQX5@50557|Insecta	33208|Metazoa	C	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.2.29	ko:K15407	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_102356_1	7425.NV22981-PA	5.17e-10	67.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	1.1.1.206	ko:K08081,ko:K21596	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R02832	RC00144	ko00000,ko00001,ko01000,ko03000	-	-	-	Exo_endo_phos_2,RVT_1,RVT_3
k59_252460_1	1123393.KB891330_gene840	3.73e-65	207.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,1KRDT@119069|Hydrogenophilales	119069|Hydrogenophilales	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
k59_301822_1	986075.CathTA2_0026	1.07e-28	115.0	COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,4HCE5@91061|Bacilli	91061|Bacilli	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_29,rve
k59_232774_1	1229909.NSED_01245	1.27e-135	393.0	arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_113890_1	9597.XP_008958403.1	0.000433	45.1	COG2036@1|root,COG5262@1|root,KOG1744@1|root,KOG1744@2759|Eukaryota,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,KOG3467@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JGKY@40674|Mammalia,35PSM@314146|Euarchontoglires,4MJ8Y@9443|Primates,4N6K1@9604|Hominidae	33208|Metazoa	B	nucleosomal DNA binding	H3F3C	-	-	ko:K11253,ko:K11254	ko05034,ko05202,ko05203,ko05322,map05034,map05202,map05203,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	CENP-T_C,Histone,Histone_H2A_C
k59_3888_1	10224.XP_006812172.1	3.71e-29	120.0	2D1AE@1|root,2SHBM@2759|Eukaryota,3AFP7@33154|Opisthokonta,3BY0Y@33208|Metazoa,3DET1@33213|Bilateria	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17
k59_73156_1	158500.BV97_03654	1.27e-55	201.0	COG2390@1|root,COG4584@1|root,COG2390@2|Bacteria,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,2KCS3@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_253643_2	1229909.NSED_03475	5.21e-23	94.0	COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota	651137|Thaumarchaeota	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_193953_1	7897.ENSLACP00000006409	1.14e-44	173.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X6K@33154|Opisthokonta,3BK4A@33208|Metazoa,3CYZ9@33213|Bilateria,48RT4@7711|Chordata,49N6K@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_144002_1	7159.AAEL017571-PA	2.59e-63	211.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_263870_1	106582.XP_004539419.1	8.34e-25	108.0	2CN36@1|root,2QTNN@2759|Eukaryota,38FJC@33154|Opisthokonta,3BM27@33208|Metazoa,3D0HQ@33213|Bilateria,48H4M@7711|Chordata,49D09@7742|Vertebrata	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_193958_1	1236908.wNo_07510	6.5e-135	387.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,47EVU@766|Rickettsiales	766|Rickettsiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
k59_153467_1	400682.PAC_15724566	1.19e-10	67.0	COG2801@1|root,KOG0017@2759|Eukaryota,39UIR@33154|Opisthokonta,3BN16@33208|Metazoa	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_134506_4	264203.ZMO0628	1.7e-10	66.6	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	MA20_08330	-	-	-	-	-	-	-	-	-	-	-	-
k59_193961_1	1205680.CAKO01000008_gene4172	1.85e-21	94.4	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_113915_1	1288494.EBAPG3_800	1.06e-74	229.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,372KJ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_113915_2	1123392.AQWL01000004_gene2534	1.35e-22	91.7	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1KRKY@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_263889_1	1459636.NTE_02749	2.37e-135	417.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_174041_1	751994.AGIG01000028_gene1913	1.08e-08	56.2	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k59_174041_2	1288494.EBAPG3_29140	6.82e-40	134.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,373AG@32003|Nitrosomonadales	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_174041_3	1112274.KI911560_gene1080	6.63e-22	89.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,2KMJT@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_64520_1	7029.ACYPI061311-PA	7.56e-27	117.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_203892_1	436308.Nmar_1193	9.17e-87	265.0	COG1064@1|root,arCOG01455@2157|Archaea,41SK3@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k59_193990_1	7425.NV18552-PA	3.02e-37	137.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_84738_1	1229909.NSED_00450	4.44e-18	82.8	COG1819@1|root,arCOG01393@2157|Archaea,41T16@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
k59_94771_1	7029.ACYPI33688-PA	2.6e-33	140.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_293703_1	570417.WP1376	1.88e-115	343.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,47F88@766|Rickettsiales	766|Rickettsiales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
k59_73202_1	34740.HMEL012162-PA	1.72e-27	116.0	COG2110@1|root,KOG1075@1|root,KOG1075@2759|Eukaryota,KOG2633@2759|Eukaryota,38FDD@33154|Opisthokonta,3BB0M@33208|Metazoa,3CW6H@33213|Bilateria,41U7K@6656|Arthropoda,3SI3Z@50557|Insecta,448DX@7088|Lepidoptera	33208|Metazoa	BK	Divergent CRAL/TRIO domain	GDAP2	GO:0001101,GO:0008150,GO:0010033,GO:0032526,GO:0033993,GO:0042221,GO:0050896,GO:1901700	-	-	-	-	-	-	-	-	-	-	CRAL_TRIO_2,Macro
k59_253699_1	570417.WP0597	2.75e-113	325.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,47FGC@766|Rickettsiales	766|Rickettsiales	L	Conserved hypothetical protein 95	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
k59_194947_1	7070.TC002266-PA	6.32e-84	266.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_254701_1	7029.ACYPI49930-PA	0.000862	48.5	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,SCAN,rve,zf-CCHC
k59_274894_1	330214.NIDE2457	1.82e-173	506.0	COG0542@1|root,COG0542@2|Bacteria,3J0B4@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_114753_1	570417.WP0199	8.83e-283	786.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,47EW9@766|Rickettsiales	766|Rickettsiales	D	Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity)	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
k59_135695_1	570417.WP1121	5.44e-252	706.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,47F1H@766|Rickettsiales	766|Rickettsiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_175006_1	1236908.wNo_03980	1.47e-140	406.0	COG2223@1|root,COG2223@2|Bacteria,1QWJ1@1224|Proteobacteria	1224|Proteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_264980_1	1415779.JOMH01000001_gene183	4.16e-42	152.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_45785_1	7070.TC002223-PA	5.49e-26	112.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,MBD,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_294710_1	1236908.wNo_05620	9.42e-179	498.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,47F02@766|Rickettsiales	766|Rickettsiales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
k59_274911_1	502025.Hoch_1127	2.47e-15	82.8	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales	28221|Deltaproteobacteria	H	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_45797_1	767434.Fraau_1049	2.67e-58	193.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X47D@135614|Xanthomonadales	135614|Xanthomonadales	E	Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine	metX	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_185280_1	13735.ENSPSIP00000000799	7.39e-80	269.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_224680_1	7029.ACYPI56743-PA	2.96e-09	63.2	COG2801@1|root,KOG0017@2759|Eukaryota,3A74Q@33154|Opisthokonta,3BTMT@33208|Metazoa,3DADB@33213|Bilateria,420V7@6656|Arthropoda,3SQ7K@50557|Insecta	33208|Metazoa	L	Integrase core domain	-	-	-	ko:K18403	-	-	-	-	ko00000,ko03036	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC
k59_35681_1	7029.ACYPI067286-PA	2.58e-15	79.7	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria,42261@6656|Arthropoda	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10577	ko03013,ko04064,ko04120,ko05206,map03013,map04064,map04120,map05206	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko04121	-	-	-	RVT_1
k59_204827_1	948106.AWZT01000001_gene5084	1.53e-70	234.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1K1D1@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_55413_1	1229909.NSED_06165	7.76e-159	464.0	COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Large family of predicted nucleotide-binding domains	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,T2SSE
k59_135741_1	7029.ACYPI38899-PA	2.69e-22	102.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_284114_1	163164.WD_1082	2.52e-296	832.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1QVTW@1224|Proteobacteria,2TWJK@28211|Alphaproteobacteria,47EUW@766|Rickettsiales	766|Rickettsiales	CEH	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	gltD	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_144975_2	522306.CAP2UW1_3892	1.48e-16	77.8	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
k59_194992_2	331869.BAL199_12941	6.96e-130	381.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VFEC@28211|Alphaproteobacteria,4BQWR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_233621_1	1229909.NSED_01515	3.69e-72	224.0	COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Amino acid kinase family	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_284132_1	7070.TC004344-PA	2.28e-39	149.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3C0YC@33208|Metazoa,3DH14@33213|Bilateria	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_135769_1	1242864.D187_009686	2.3e-05	51.6	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2YXY1@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k59_25255_1	7029.ACYPI50162-PA	2.56e-34	137.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_154485_1	570417.WP0920	1.08e-70	223.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
k59_224724_1	7176.CPIJ011805-PA	2.73e-23	103.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,42CJI@6656|Arthropoda,3SRHB@50557|Insecta,459H7@7147|Diptera,45K6P@7148|Nematocera	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_224725_1	1131266.ARWQ01000011_gene119	9.19e-66	214.0	COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
k59_145003_1	436308.Nmar_1073	5e-26	116.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
k59_165630_1	570417.WP0275	2.57e-87	266.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	anK3	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,SUFU
k59_165630_2	570417.WP0274	5.46e-55	179.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K20480	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_19,HTH_26,HTH_3,HTH_31
k59_4918_1	2711.XP_006465491.1	4.27e-41	157.0	COG2801@1|root,KOG4658@1|root,KOG0017@2759|Eukaryota,KOG4658@2759|Eukaryota,37RIF@33090|Viridiplantae,3G9AM@35493|Streptophyta	35493|Streptophyta	K	cysteine-rich RLK (RECEPTOR-like protein kinase) 8	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve
k59_303739_1	744979.R2A130_1260	3.63e-53	182.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_294798_1	1245471.PCA10_45510	2.84e-69	217.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1YF81@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
k59_124921_1	323848.Nmul_A0764	7.26e-143	424.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,371Q6@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_4928_1	1236908.wNo_04320	5.04e-127	379.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2TQRS@28211|Alphaproteobacteria,47EVC@766|Rickettsiales	766|Rickettsiales	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
k59_284164_1	436308.Nmar_1398	8.42e-108	329.0	COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota	651137|Thaumarchaeota	L	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
k59_26345_1	1163617.SCD_n00511	2.92e-115	352.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
k59_314975_1	570417.WP0342	6.33e-158	451.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,47FRD@766|Rickettsiales	766|Rickettsiales	L	Recombinase	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
k59_155526_1	1236908.wNo_00080	2.08e-34	120.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,47FCY@766|Rickettsiales	766|Rickettsiales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k59_276134_1	7029.ACYPI061166-PA	8.43e-50	179.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_47148_2	7159.AAEL017299-PA	3.27e-27	118.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_37045_1	768671.ThimaDRAFT_1939	5.2e-67	217.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1T5B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_97413_1	436308.Nmar_1388	2.62e-113	340.0	COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
k59_314980_1	7029.ACYPI33401-PA	4.16e-29	121.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1,RVT_3
k59_304637_2	1121374.KB891583_gene2884	1.86e-23	102.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_225992_1	1229909.NSED_09825	2.49e-13	67.4	COG0603@1|root,arCOG00039@2157|Archaea,41SGR@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Queuosine biosynthesis protein QueC	-	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_225992_2	1131266.ARWQ01000001_gene1326	6.28e-48	163.0	COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_137163_1	7176.CPIJ016155-PA	2.58e-40	147.0	2D0Z5@1|root,2SG31@2759|Eukaryota,39MUX@33154|Opisthokonta,3CPED@33208|Metazoa,3E5JE@33213|Bilateria,421WR@6656|Arthropoda,3SSH7@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_225995_1	436308.Nmar_0206	1.88e-180	522.0	COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18593	ko00720,ko01120,map00720,map01120	-	R10758	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
k59_167051_2	991905.SL003B_1106	8.8e-34	127.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,2TQM1@28211|Alphaproteobacteria,4BR5W@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C
k59_137167_1	570417.WP0913	4.68e-175	519.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,47FZJ@766|Rickettsiales	766|Rickettsiales	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_196336_2	402777.KB235903_gene2356	8.09e-43	154.0	COG1252@1|root,COG1252@2|Bacteria,1G21Z@1117|Cyanobacteria,1H7TT@1150|Oscillatoriales	1117|Cyanobacteria	C	Belongs to the selenophosphate synthase 1 family. Class I subfamily	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
k59_67351_1	864051.BurJ1DRAFT_3428	3.11e-84	258.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,2VKSA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
k59_26373_1	7425.NV18508-PA	3.45e-10	68.6	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_115901_1	436308.Nmar_0806	2.16e-11	60.8	COG0185@1|root,arCOG04099@2157|Archaea,41SMH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_115901_2	650150.ERH_1170	3.23e-07	51.2	COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,3VRDE@526524|Erysipelotrichia	526524|Erysipelotrichia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_167067_1	1236908.wNo_05410	6.19e-13	67.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,47G2P@766|Rickettsiales	766|Rickettsiales	F	AIR synthase related protein, N-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_167067_2	570417.WP0875	1.09e-102	300.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,47FF5@766|Rickettsiales	766|Rickettsiales	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_126009_1	1288494.EBAPG3_13710	1.57e-90	275.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,372Q2@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
k59_304650_1	27923.ML08883a-PA	5.48e-37	142.0	KOG0977@1|root,KOG1075@1|root,KOG0977@2759|Eukaryota,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_244500_1	7176.CPIJ002635-PA	3.19e-59	192.0	2D5GH@1|root,2SYGV@2759|Eukaryota,3ASKA@33154|Opisthokonta,3C478@33208|Metazoa,3DJV7@33213|Bilateria,423NM@6656|Arthropoda,3SXI7@50557|Insecta,459TE@7147|Diptera,45KYV@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-CCHC
k59_226015_1	1236908.wNo_02110	4.37e-54	187.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,2UA2F@28211|Alphaproteobacteria,47F95@766|Rickettsiales	766|Rickettsiales	O	ankyrin repeat	-	-	-	ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
k59_226015_2	1236908.wNo_02100	1.35e-34	124.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
k59_87332_1	436308.Nmar_0517	3.54e-39	139.0	COG1405@1|root,arCOG01981@2157|Archaea,41S8Y@651137|Thaumarchaeota	651137|Thaumarchaeota	K	factor TFIIB	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_87332_2	1131266.ARWQ01000005_gene831	1.06e-28	105.0	COG3277@1|root,arCOG02466@2157|Archaea,41SVG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	RNA-binding protein involved in rRNA processing	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
k59_87332_3	436308.Nmar_0519	4.61e-34	119.0	COG1400@1|root,arCOG01217@2157|Archaea,41SR5@651137|Thaumarchaeota	651137|Thaumarchaeota	U	SRP19 protein	-	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
k59_216284_1	436308.Nmar_0256	6.75e-91	273.0	COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
k59_266504_1	1458275.AZ34_00810	1.62e-111	328.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,4ABCI@80864|Comamonadaceae	28216|Betaproteobacteria	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_256041_1	1236908.wNo_09140	9.84e-114	362.0	COG1672@1|root,COG5539@1|root,COG1672@2|Bacteria,COG5539@2|Bacteria	2|Bacteria	O	protein K27-linked deubiquitination	-	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0036210,GO:0036211,GO:0043087,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044033,GO:0044238,GO:0046872,GO:0050568,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009,GO:0071704,GO:0140096,GO:1901564	-	ko:K06921,ko:K15354	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	AAA_16,KAP_NTPase,Mrr_cat,NACHT,SIR2_2,Tox-PLDMTX
k59_315133_1	7668.SPU_010393-tr	6.81e-26	120.0	COG1199@1|root,KOG1075@1|root,KOG1075@2759|Eukaryota,KOG1132@2759|Eukaryota,391E5@33154|Opisthokonta,3CJ6Y@33208|Metazoa,3DHJR@33213|Bilateria	2759|Eukaryota	KL	Reverse transcriptase (RNA-dependent DNA polymerase)	-	GO:0000018,GO:0000166,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006282,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0009987,GO:0010569,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0051276,GO:0060255,GO:0065007,GO:0070035,GO:0071103,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901363,GO:2000779,GO:2001020	3.6.4.12	ko:K11136	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD_2,Helicase_C_2,RVT_1
k59_67517_1	1125973.JNLC01000011_gene454	3.09e-41	143.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_15120	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_97625_1	7213.XP_004520233.1	4.33e-49	178.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_57004_1	1100720.ALKN01000040_gene2146	4.74e-102	304.0	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VJ2H@28216|Betaproteobacteria,4ACX2@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD TfdA	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_226150_1	7668.SPU_024592-tr	1.05e-39	163.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_206084_1	7213.XP_004520373.1	2.16e-34	139.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,429UH@6656|Arthropoda,3T0UB@50557|Insecta,458R2@7147|Diptera	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_315145_1	1131266.ARWQ01000001_gene1251	7.76e-93	283.0	COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
k59_256050_1	7668.SPU_000635-tr	1.56e-58	203.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria	33208|Metazoa	L	retrotransposable element Tf2 155 kDa protein type 1-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_196495_1	317936.Nos7107_3702	4.41e-05	50.8	COG4191@1|root,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1HIYH@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA
k59_137388_1	436308.Nmar_0780	5.82e-171	498.0	COG0046@1|root,arCOG00641@2157|Archaea,41S6S@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_137389_1	1449126.JQKL01000046_gene2081	0.000164	50.1	COG4722@1|root,COG4722@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Sipho_tail
k59_26541_2	436308.Nmar_1534	4.99e-65	209.0	COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
k59_315150_1	977880.RALTA_A3016	7.91e-92	286.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
k59_57021_1	7425.NV18233-PA	1.2e-64	229.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXJQ@33208|Metazoa,3DGER@33213|Bilateria,422ER@6656|Arthropoda,3SR16@50557|Insecta,46M71@7399|Hymenoptera	33208|Metazoa	S	Domain of unknown function (DUF4780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780,Exo_endo_phos_2,RNase_H,RVT_1
k59_67532_1	436308.Nmar_1631	8.24e-54	179.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_67532_2	436308.Nmar_1630	2.83e-50	162.0	COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota	651137|Thaumarchaeota	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k59_6146_1	56110.Oscil6304_5021	1.13e-13	77.0	COG3464@1|root,COG3464@2|Bacteria,1G0IQ@1117|Cyanobacteria,1H73F@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Transposase	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
k59_244634_1	375286.mma_1852	2.93e-45	158.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4731A@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_87384_1	1095769.CAHF01000013_gene3280	7.76e-25	102.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,4727Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
k59_256066_2	1131266.ARWQ01000032_gene1003	3.11e-49	164.0	COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
k59_186863_1	7159.AAEL017170-PA	4.14e-19	91.7	2FJDT@1|root,2TKV5@2759|Eukaryota,39I0C@33154|Opisthokonta,3CMTT@33208|Metazoa,3E3FQ@33213|Bilateria,42CGF@6656|Arthropoda,3SXJA@50557|Insecta,459VC@7147|Diptera,45M36@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_97661_1	570417.WP1385	8.1e-168	498.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,47EX4@766|Rickettsiales	766|Rickettsiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18989	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718,M00720	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.30	-	-	ACR_tran
k59_244639_1	1265313.HRUBRA_00932	1.33e-19	90.1	29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_167293_1	1131269.AQVV01000014_gene191	1.93e-21	87.8	COG1006@1|root,COG1006@2|Bacteria	2|Bacteria	P	Multisubunit Na H antiporter MnhC subunit	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
k59_167293_2	1210908.HSB1_09930	1.51e-08	59.7	COG0651@1|root,arCOG01537@2157|Archaea,2XU88@28890|Euryarchaeota,23S0I@183963|Halobacteria	183963|Halobacteria	C	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	phaD3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_176386_1	1229909.NSED_06190	3.17e-41	140.0	COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
k59_176386_2	436308.Nmar_1055	1.23e-91	281.0	COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota	651137|Thaumarchaeota	L	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_285352_1	1349767.GJA_2110	3.57e-68	214.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,477B7@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nosF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_196523_1	1229909.NSED_06415	1.3e-91	287.0	COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota	651137|Thaumarchaeota	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k59_186880_1	522306.CAP2UW1_3046	7.77e-151	432.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,1KQYZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_186880_2	323848.Nmul_A2332	3.02e-14	72.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,372BM@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	oppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_87407_1	395493.BegalDRAFT_3524	5.52e-91	275.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,460BF@72273|Thiotrichales	72273|Thiotrichales	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
k59_285362_1	1229909.NSED_02570	1.42e-52	175.0	COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_155669_3	7029.ACYPI56547-PA	1.89e-29	128.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_137434_1	69319.XP_008553387.1	2.45e-49	184.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,46IFZ@7399|Hymenoptera	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RRM_1,RVT_1,rve,zf-H2C2
k59_97698_1	281687.CJA18259a	6.18e-13	75.9	COG5103@1|root,KOG1831@2759|Eukaryota,38EGY@33154|Opisthokonta,3BGGB@33208|Metazoa,3D0C2@33213|Bilateria,40BBR@6231|Nematoda,1KVBZ@119089|Chromadorea,40Y3V@6236|Rhabditida	33208|Metazoa	K	CCR4-NOT transcription complex subunit 1 HEAT repeat	CNOT1	GO:0000003,GO:0000075,GO:0000077,GO:0000122,GO:0000175,GO:0000226,GO:0000278,GO:0000288,GO:0000289,GO:0000932,GO:0000956,GO:0001701,GO:0001824,GO:0001825,GO:0001829,GO:0002064,GO:0002065,GO:0002066,GO:0002119,GO:0002164,GO:0003006,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004535,GO:0004540,GO:0005102,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006355,GO:0006357,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006977,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007093,GO:0007154,GO:0007165,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007346,GO:0008134,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009966,GO:0009968,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010564,GO:0010603,GO:0010604,GO:0010605,GO:0010606,GO:0010608,GO:0010629,GO:0010638,GO:0010646,GO:0010648,GO:0010948,GO:0016043,GO:0016070,GO:0016071,GO:0016441,GO:0016458,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0019904,GO:0019953,GO:0022402,GO:0022412,GO:0022414,GO:0023051,GO:0023052,GO:0023057,GO:0030014,GO:0030015,GO:0030154,GO:0030330,GO:0030331,GO:0030707,GO:0030855,GO:0030953,GO:0031047,GO:0031122,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031329,GO:0031331,GO:0031334,GO:0031570,GO:0031571,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032947,GO:0032991,GO:0033043,GO:0033143,GO:0033144,GO:0033146,GO:0033147,GO:0033554,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0035194,GO:0035195,GO:0035257,GO:0035258,GO:0035556,GO:0035770,GO:0036464,GO:0040001,GO:0040007,GO:0040029,GO:0042770,GO:0042974,GO:0043009,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0044773,GO:0044774,GO:0044783,GO:0044819,GO:0045786,GO:0045787,GO:0045892,GO:0045930,GO:0045934,GO:0045935,GO:0046483,GO:0046700,GO:0048385,GO:0048387,GO:0048468,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048589,GO:0048609,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051234,GO:0051239,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051254,GO:0051293,GO:0051427,GO:0051640,GO:0051641,GO:0051649,GO:0051653,GO:0051656,GO:0051704,GO:0051716,GO:0051726,GO:0060211,GO:0060213,GO:0060255,GO:0060429,GO:0061013,GO:0061014,GO:0065007,GO:0070016,GO:0071156,GO:0071158,GO:0071704,GO:0071840,GO:0072331,GO:0072395,GO:0072401,GO:0072413,GO:0072422,GO:0072431,GO:0080090,GO:0090068,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097435,GO:0140098,GO:1900151,GO:1900153,GO:1901360,GO:1901361,GO:1901575,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902115,GO:1902117,GO:1902400,GO:1902402,GO:1902403,GO:1902679,GO:1902806,GO:1902807,GO:1902850,GO:1903047,GO:1903311,GO:1903313,GO:1903506,GO:1903507,GO:1990904,GO:2000036,GO:2000045,GO:2000112,GO:2000113,GO:2000134,GO:2001141	-	ko:K12604	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019	-	-	-	CNOT1_CAF1_bind,CNOT1_HEAT,CNOT1_TTP_bind,DUF3819,Not1
k59_167314_1	1236908.wNo_09550	8.41e-54	169.0	COG0769@1|root,COG0769@2|Bacteria	2|Bacteria	M	UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity	murE	-	6.3.2.13	ko:K01928,ko:K01932	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_167314_2	570417.WP0205	1.54e-289	792.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,47EY1@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k59_167314_3	1236908.wNo_09570	3.5e-48	162.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,47F1I@766|Rickettsiales	766|Rickettsiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
k59_206151_1	436308.Nmar_1689	2.31e-111	323.0	COG1394@1|root,arCOG04101@2157|Archaea,41T0N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
k59_16511_2	1123392.AQWL01000005_gene2967	4.12e-50	162.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1KT3H@119069|Hydrogenophilales	119069|Hydrogenophilales	P	ApaG domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF525
k59_196543_1	7029.ACYPI52857-PA	7.52e-49	184.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_296219_1	7029.ACYPI008531-PA	6.61e-79	275.0	COG2801@1|root,KOG3510@1|root,KOG0017@2759|Eukaryota,KOG3510@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EBZ8@33342|Paraneoptera	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_176421_1	7091.BGIBMGA013997-TA	6.93e-27	114.0	COG0507@1|root,KOG3740@1|root,KOG0987@2759|Eukaryota,KOG3740@2759|Eukaryota,38FI7@33154|Opisthokonta,3BJBX@33208|Metazoa,3CSM4@33213|Bilateria,41XNS@6656|Arthropoda,3SHSP@50557|Insecta,449AJ@7088|Lepidoptera	33208|Metazoa	L	Coiled-coil and interaction region of P66A and P66B with MBD2	GATAD2A	GO:0000118,GO:0000122,GO:0000228,GO:0000785,GO:0000790,GO:0000981,GO:0001568,GO:0001701,GO:0001708,GO:0001838,GO:0001841,GO:0001842,GO:0001843,GO:0001944,GO:0002009,GO:0003008,GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006355,GO:0006357,GO:0006725,GO:0006807,GO:0007275,GO:0007399,GO:0007507,GO:0007610,GO:0007611,GO:0007612,GO:0008150,GO:0008152,GO:0008219,GO:0008582,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010171,GO:0010172,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0012501,GO:0014020,GO:0016331,GO:0016581,GO:0017053,GO:0019219,GO:0019222,GO:0021506,GO:0021915,GO:0021995,GO:0030154,GO:0030674,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032259,GO:0032501,GO:0032502,GO:0032991,GO:0034641,GO:0035051,GO:0035148,GO:0035239,GO:0035295,GO:0040008,GO:0043009,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044728,GO:0045165,GO:0045887,GO:0045892,GO:0045927,GO:0045934,GO:0046483,GO:0046958,GO:0046959,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048598,GO:0048638,GO:0048639,GO:0048646,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0050877,GO:0050890,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051239,GO:0051240,GO:0051252,GO:0051253,GO:0051960,GO:0051962,GO:0051963,GO:0051965,GO:0060090,GO:0060255,GO:0060429,GO:0060562,GO:0060571,GO:0060606,GO:0060911,GO:0060912,GO:0065007,GO:0065008,GO:0070013,GO:0070603,GO:0071704,GO:0072175,GO:0072358,GO:0072359,GO:0080090,GO:0090304,GO:0090545,GO:0090568,GO:0140110,GO:1901360,GO:1902494,GO:1902679,GO:1903506,GO:1903507,GO:1904396,GO:1904398,GO:1904949,GO:2000026,GO:2000112,GO:2000113,GO:2001141	-	ko:K10310	-	-	-	-	ko00000,ko04121	-	-	-	GATA,P66_CC
k59_277339_1	570417.WP0851	6.03e-85	250.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,47FGB@766|Rickettsiales	766|Rickettsiales	FG	Protein kinase C inhibitor 1	pkcI	-	-	-	-	-	-	-	-	-	-	-	HIT
k59_227292_1	1229909.NSED_03305	1.01e-87	263.0	arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_217358_1	163164.WD_0616	1.66e-109	331.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,47ET5@766|Rickettsiales	766|Rickettsiales	V	COG1132 ABC-type multidrug transport system, ATPase and permease components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_68520_1	1125973.JNLC01000011_gene592	3.91e-91	277.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_207071_1	1380355.JNIJ01000080_gene5000	1.54e-72	243.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JRJE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
k59_267831_1	31234.CRE14091	8.56e-50	182.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_38373_1	7159.AAEL017378-PA	1.13e-34	133.0	COG0050@1|root,KOG0460@2759|Eukaryota,38BHM@33154|Opisthokonta,3BE5J@33208|Metazoa,3CUKG@33213|Bilateria,41VN7@6656|Arthropoda,3SFX6@50557|Insecta,4526Y@7147|Diptera,45GUA@7148|Nematocera	33208|Metazoa	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	TUFM	GO:0000278,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006996,GO:0007030,GO:0007049,GO:0008135,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009059,GO:0009295,GO:0009636,GO:0009987,GO:0010033,GO:0010256,GO:0010467,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0034641,GO:0034645,GO:0042221,GO:0042493,GO:0042645,GO:0043043,GO:0043170,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0046677,GO:0050896,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:0097305,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901700	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_197598_1	67593.Physo129535	3.64e-50	189.0	COG2801@1|root,KOG0017@2759|Eukaryota,3QGAK@4776|Peronosporales	67593.Physo129535|-	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_58128_1	436308.Nmar_1718	2.81e-19	85.9	COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
k59_58128_2	1229909.NSED_09145	7.13e-22	93.2	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
k59_106278_1	420324.KI912035_gene2494	5.54e-92	275.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
k59_106278_2	864702.OsccyDRAFT_1820	1.86e-14	68.9	COG3293@1|root,COG3293@2|Bacteria,1GHMS@1117|Cyanobacteria,1HCWV@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
k59_127246_1	1123072.AUDH01000001_gene2788	4.4e-19	92.4	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JPCT@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.31	ko:K00666,ko:K16876	ko00365,ko01120,map00365,map01120	-	R02986	RC00004,RC00174	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_305464_1	1131266.ARWQ01000001_gene1158	4.21e-14	69.3	COG0049@1|root,arCOG04254@2157|Archaea,41S6U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_305464_2	436308.Nmar_0354	2.59e-79	237.0	COG0048@1|root,arCOG04255@2157|Archaea,41SIB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_127249_1	7029.ACYPI084940-PA	2.71e-108	352.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,41Y67@6656|Arthropoda,3SRHJ@50557|Insecta	33208|Metazoa	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve,zf-H2C2
k59_256337_2	211165.AJLN01000063_gene3785	1.85e-14	72.4	COG4293@1|root,COG4293@2|Bacteria,1G555@1117|Cyanobacteria,1JGRK@1189|Stigonemataceae	1117|Cyanobacteria	S	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
k59_87720_1	1229909.NSED_01260	2.78e-156	451.0	COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18604	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
k59_206355_1	1236908.wNo_03640	1.04e-152	436.0	COG0596@1|root,COG0596@2|Bacteria,1P0IP@1224|Proteobacteria	1224|Proteobacteria	S	Alpha beta hydrolase	sdbB	-	-	-	-	-	-	-	-	-	-	-	-
k59_244867_2	566466.NOR53_856	1.24e-10	61.6	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1J5MH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	and related enzymes	yghX	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
k59_285595_2	7159.AAEL017170-PA	5.68e-17	84.0	2FJDT@1|root,2TKV5@2759|Eukaryota,39I0C@33154|Opisthokonta,3CMTT@33208|Metazoa,3E3FQ@33213|Bilateria,42CGF@6656|Arthropoda,3SXJA@50557|Insecta,459VC@7147|Diptera,45M36@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_137736_1	7425.NV10089-PA	4.97e-41	164.0	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_176660_1	10224.XP_006825930.1	2.68e-71	254.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_167612_1	1265845.PWEIH_00500	2.49e-34	129.0	28MC2@1|root,2ZAQD@2|Bacteria,1VSEU@1239|Firmicutes,4HT1S@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_67840_1	330214.NIDE3564	2.91e-14	77.8	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
k59_26839_1	189753.AXAS01000102_gene5975	4.18e-97	295.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
k59_57346_1	281687.CJA40394	1.76e-33	139.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AV1G@33154|Opisthokonta,3C39W@33208|Metazoa,3DJI1@33213|Bilateria,40JTB@6231|Nematoda,1M357@119089|Chromadorea,40Z8W@6236|Rhabditida	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_266871_1	159087.Daro_4201	1.88e-72	234.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KUBX@206389|Rhodocyclales	206389|Rhodocyclales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k59_47703_1	7070.TC006870-PA	1.62e-38	147.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,gag-asp_proteas,rve
k59_37680_1	1057002.KB905370_gene4587	4.31e-36	140.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2V7KJ@28211|Alphaproteobacteria,4BJYD@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k59_296506_1	1459636.NTE_02739	1.3e-81	251.0	COG1741@1|root,arCOG02935@2157|Archaea	2157|Archaea	S	Belongs to the Pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
k59_226563_1	570417.WP0035	5e-122	369.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K18376	-	M00660	-	-	ko00000,ko00002,ko02044	1.C.65.1	-	-	DUF1542,Mob_Pre,Relaxase,YSIRK_signal
k59_216633_1	71139.XP_010034499.1	1.43e-31	128.0	COG2801@1|root,COG4299@1|root,KOG0017@2759|Eukaryota,KOG4683@2759|Eukaryota,37RKH@33090|Viridiplantae,3GGZK@35493|Streptophyta	35493|Streptophyta	L	strictosidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,Retrotrans_gag,rve
k59_167629_1	1236908.wNo_08230	2.87e-28	106.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,47F8F@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
k59_167629_2	570417.WP1166	5.78e-155	436.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,47F5N@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k59_87760_1	243233.MCA0016	6.76e-97	301.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales	135618|Methylococcales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_226565_1	1125973.JNLC01000011_gene592	5.02e-96	290.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_266876_1	10224.XP_002731288.1	5.87e-31	128.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria	33208|Metazoa	G	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve,zf-CCHC
k59_176680_1	7425.NV18233-PA	7.47e-68	243.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXJQ@33208|Metazoa,3DGER@33213|Bilateria,422ER@6656|Arthropoda,3SR16@50557|Insecta,46M71@7399|Hymenoptera	33208|Metazoa	S	Domain of unknown function (DUF4780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780,Exo_endo_phos_2,RNase_H,RVT_1
k59_266879_2	570417.WP0882	1.77e-181	506.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,47FAR@766|Rickettsiales	766|Rickettsiales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
k59_276705_1	365046.Rta_27720	1.89e-11	69.7	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,4ACTE@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,HemolysinCabind
k59_256391_1	161934.XP_010676254.1	3.16e-55	199.0	COG2801@1|root,KOG0017@2759|Eukaryota,3894V@33090|Viridiplantae,3GY0Z@35493|Streptophyta	35493|Streptophyta	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2
k59_266896_1	305700.B447_03703	9.23e-76	237.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KUP4@206389|Rhodocyclales	206389|Rhodocyclales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_266896_2	323848.Nmul_A1095	4.11e-19	82.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,371SU@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
k59_206416_2	159087.Daro_2459	4.13e-38	137.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,2KV1Z@206389|Rhodocyclales	206389|Rhodocyclales	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_296526_1	7029.ACYPI52857-PA	5.91e-75	260.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_146591_1	570417.WP0384	1.78e-159	452.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,47F9J@766|Rickettsiales	766|Rickettsiales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
k59_146591_2	570417.WP0383	4.61e-235	682.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria	1224|Proteobacteria	KT	ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4
k59_146591_3	1236908.wNo_10030	2.73e-232	645.0	COG1757@1|root,COG1757@2|Bacteria,1MX0T@1224|Proteobacteria,2UNJJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
k59_146591_4	570417.WP1375	2.42e-237	653.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,47EUM@766|Rickettsiales	766|Rickettsiales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
k59_276710_1	6238.CBG24470	2.67e-31	128.0	COG2801@1|root,KOG1164@1|root,KOG0017@2759|Eukaryota,KOG1164@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,411FR@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,gag-asp_proteas,rve
k59_167657_1	330214.NIDE3560	2.62e-114	338.0	COG1894@1|root,COG1894@2|Bacteria,3J0WA@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
k59_176703_1	7668.SPU_024592-tr	5.33e-28	122.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_26872_2	436308.Nmar_1022	3.3e-52	169.0	COG1917@1|root,arCOG03444@2157|Archaea,41SV4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_6479_1	76114.ebA729	1.9e-19	91.7	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2VHPP@28216|Betaproteobacteria,2KYFM@206389|Rhodocyclales	206389|Rhodocyclales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_196863_2	1381123.AYOD01000035_gene3395	2.42e-44	154.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2TS3C@28211|Alphaproteobacteria,43GX4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	potC	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
k59_216682_1	1266925.JHVX01000003_gene540	3e-79	255.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,371MP@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
k59_116352_1	436308.Nmar_1706	3.66e-35	130.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
k59_116352_2	436308.Nmar_1705	1.97e-68	212.0	COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
k59_315509_1	927677.ALVU02000001_gene1806	1.41e-42	146.0	COG5485@1|root,COG5485@2|Bacteria,1GCKP@1117|Cyanobacteria	1117|Cyanobacteria	S	Ester cyclase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	SnoaL
k59_98038_1	382464.ABSI01000012_gene2146	7.27e-66	220.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
k59_234939_1	1236908.wNo_01330	9.79e-82	243.0	28HUJ@1|root,2Z819@2|Bacteria,1MW8B@1224|Proteobacteria,2TSXB@28211|Alphaproteobacteria,47GB0@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_234939_2	1236908.wNo_01340	2.44e-110	327.0	COG0358@1|root,COG3598@1|root,COG0358@2|Bacteria,COG3598@2|Bacteria	2|Bacteria	L	Psort location Cytoplasmic, score	-	-	3.6.4.12	ko:K17680	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	AAA_25,DUF3987,DnaB_C,Toprim_2,Toprim_4
k59_207552_1	1187851.A33M_0090	3.21e-102	305.0	COG1638@1|root,COG1638@2|Bacteria,1PJG1@1224|Proteobacteria,2V8IQ@28211|Alphaproteobacteria,3FEKB@34008|Rhodovulum	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_245949_1	1229909.NSED_00895	1.02e-209	583.0	COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
k59_49022_1	570417.WP1227	3.6e-147	428.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,47F2D@766|Rickettsiales	766|Rickettsiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k59_18075_1	1325372.N0DQU3_9CAUD	3.46e-29	131.0	4QB9Y@10239|Viruses,4QWGZ@35237|dsDNA viruses  no RNA stage,4QPTT@28883|Caudovirales,4QJD7@10662|Myoviridae	10662|Myoviridae	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18075_2	1161931.J7F9D8_9CAUD	1.67e-21	89.7	4QEGD@10239|Viruses,4QVU1@35237|dsDNA viruses  no RNA stage,4QPN9@28883|Caudovirales,4QJCM@10662|Myoviridae	10662|Myoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_18087_2	1120999.JONM01000001_gene1182	4.79e-09	56.6	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,2VI8T@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
k59_127768_1	1236908.wNo_08510	8.95e-18	79.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,47EZW@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_127768_2	1236908.wNo_08520	5.96e-211	589.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,47FA5@766|Rickettsiales	766|Rickettsiales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Peptidase_M48,TPR_19
k59_49034_1	1485544.JQKP01000010_gene789	1.67e-78	248.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,44VH5@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM peptidase S1 and S6 chymotrypsin Hap	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_49034_2	1163617.SCD_n01392	8.14e-32	123.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	negative regulator of sigma E activity	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_117560_1	570417.WP0615	7.63e-14	70.1	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,47F20@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_198200_1	1236908.wNo_07960	1.31e-11	63.5	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,47EY7@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_169050_1	570417.WP0407	2.23e-138	438.0	COG0457@1|root,COG0666@1|root,COG1672@1|root,COG2931@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG1672@2|Bacteria,COG2931@2|Bacteria,1MWRF@1224|Proteobacteria,2U9VQ@28211|Alphaproteobacteria,47F2N@766|Rickettsiales	766|Rickettsiales	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5,GerE,NB-ARC,TPR_12,TPR_2,TPR_7,TPR_8
k59_188639_2	1218084.BBJK01000007_gene906	1.6e-108	326.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2W1P1@28216|Betaproteobacteria,1K0XN@119060|Burkholderiaceae	28216|Betaproteobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
k59_305844_2	1123248.KB893343_gene11	8.26e-14	75.1	COG2801@1|root,COG2801@2|Bacteria,4NPG9@976|Bacteroidetes,1IYMY@117747|Sphingobacteriia	976|Bacteroidetes	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,rve
k59_139241_1	1242864.D187_002884	3.94e-29	111.0	2AW22@1|root,31MWT@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1360)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1360
k59_178063_2	1236908.wNo_04090	1.55e-76	229.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,47FEK@766|Rickettsiales	766|Rickettsiales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
k59_281647_1	1459636.NTE_01403	7.02e-91	277.0	COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
k59_32722_1	7029.ACYPI39717-PA	2.18e-34	140.0	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI39717-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_172322_1	1236908.wNo_08150	1.8e-66	202.0	COG0355@1|root,COG0355@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
k59_172322_2	1236908.wNo_08140	3.04e-81	253.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,47ETU@766|Rickettsiales	766|Rickettsiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_162592_1	926550.CLDAP_08990	5.32e-08	55.5	COG0530@1|root,COG0530@2|Bacteria,2G6GV@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
k59_162592_2	1229909.NSED_03080	2.39e-35	122.0	arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_262052_1	436308.Nmar_0440	6.61e-92	276.0	COG0061@1|root,arCOG01348@2157|Archaea,41SHP@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_92763_1	7029.ACYPI53110-PA	7.42e-85	285.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_301414_1	7070.TC004227-PA	5.4e-42	157.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_82776_1	436308.Nmar_1393	6.9e-74	226.0	COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_172345_1	1229909.NSED_03335	9.7e-81	246.0	COG1938@1|root,arCOG00347@2157|Archaea,41T2Y@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
k59_172345_2	1229909.NSED_03330	5.28e-80	244.0	COG1280@1|root,arCOG01947@2157|Archaea,41T36@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k59_221970_1	570417.WP0511	1.28e-200	564.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,47F3M@766|Rickettsiales	766|Rickettsiales	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
k59_202218_1	1229909.NSED_01295	9.57e-111	327.0	COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_192266_1	398525.KB900701_gene7408	3.12e-132	384.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2TVM0@28211|Alphaproteobacteria,3JW6H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	ligJ	-	4.1.1.45,4.2.1.83	ko:K03392,ko:K10220	ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120	M00038	R04323,R04478	RC00498,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_172359_1	1236908.wNo_03000	3.61e-108	333.0	COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,47F23@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	virB4-1	-	-	ko:K03199	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagE_TrbE_VirB
k59_172359_2	1236908.wNo_03010	3.34e-64	196.0	COG3702@1|root,COG3702@2|Bacteria,1NFFQ@1224|Proteobacteria,2UFJU@28211|Alphaproteobacteria,47FKA@766|Rickettsiales	766|Rickettsiales	U	Type IV secretory pathway, VirB3 components	virB3	-	-	ko:K03198	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	VirB3
k59_172359_3	1236908.wNo_03020	1.02e-12	66.6	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,47ESY@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
k59_132648_2	935565.JAEM01000006_gene3898	0.000109	47.4	2C2XN@1|root,32GT6@2|Bacteria,1REZE@1224|Proteobacteria,2U8HW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM ERF family protein	-	-	-	-	-	-	-	-	-	-	-	-	ERF
k59_2396_1	1236908.wNo_04950	5.78e-218	606.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,47FF0@766|Rickettsiales	766|Rickettsiales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_262089_1	570417.WP0601	4.27e-178	518.0	COG3704@1|root,COG3704@2|Bacteria,1P76F@1224|Proteobacteria,2UW5H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	TrbL/VirB6 plasmid conjugal transfer protein	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_2397_1	1131266.ARWQ01000009_gene925	3.57e-40	142.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_2397_2	1131266.ARWQ01000009_gene926	2.7e-39	135.0	arCOG10412@1|root,arCOG10412@2157|Archaea,41SS9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_122437_1	436308.Nmar_0053	5.48e-65	209.0	COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
k59_122437_2	1131266.ARWQ01000001_gene1302	8.45e-14	67.0	COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
k59_221987_2	1101195.Meth11DRAFT_0626	2.73e-14	73.2	COG4967@1|root,COG4967@2|Bacteria,1RKKA@1224|Proteobacteria,2VTQ8@28216|Betaproteobacteria,2KMW4@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	type IV pilus modification protein PilV	-	-	-	ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
k59_192282_1	570417.WP0680	1.47e-127	382.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_5
k59_42845_1	7260.FBpp0252600	3.33e-11	70.1	KOG2568@1|root,KOG2568@2759|Eukaryota,38HGW@33154|Opisthokonta,3BD9K@33208|Metazoa,3CV77@33213|Bilateria,41TR0@6656|Arthropoda,3SGMC@50557|Insecta,44YST@7147|Diptera,45PH5@7214|Drosophilidae	33208|Metazoa	S	Lung seven transmembrane receptor	TMEM87A	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0006810,GO:0008150,GO:0012505,GO:0016020,GO:0016192,GO:0016197,GO:0016482,GO:0031090,GO:0031984,GO:0031985,GO:0032580,GO:0042147,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0098588,GO:0098791	-	-	-	-	-	-	-	-	-	-	Lung_7-TM_R
k59_2402_1	488538.SAR116_1471	2.59e-72	227.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
k59_262094_1	1163617.SCD_n00212	3.89e-26	101.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
k59_262094_2	1131553.JIBI01000071_gene2157	2.94e-31	121.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,3728D@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_2407_1	28377.ENSACAP00000022126	2.02e-15	83.6	KOG1075@1|root,KOG1075@2759|Eukaryota,39RKB@33154|Opisthokonta,3BK61@33208|Metazoa,3CX3T@33213|Bilateria,4872C@7711|Chordata,495PJ@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1725,Exo_endo_phos,Exo_endo_phos_2,RVT_1
k59_92822_1	580332.Slit_1429	7.65e-10	56.2	2DGZJ@1|root,2ZXVD@2|Bacteria,1PA8Z@1224|Proteobacteria,2W5F6@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_92822_2	1288494.EBAPG3_13360	1.69e-09	57.8	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,372U6@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	-	-	4.1.1.19	ko:K01583	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
k59_42858_1	281687.CJA15137	4.79e-09	63.5	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3DKJZ@33213|Bilateria,40GWW@6231|Nematoda,1KZYW@119089|Chromadorea,412EV@6236|Rhabditida	33208|Metazoa	K	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_212093_1	570417.WP0829	2.96e-23	95.9	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,47F98@766|Rickettsiales	766|Rickettsiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
k59_212093_2	570417.WP0830	2.67e-55	172.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,47FMP@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k59_212093_3	1236908.wNo_04890	3.49e-79	254.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,47EVH@766|Rickettsiales	766|Rickettsiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
k59_192292_1	61853.ENSNLEP00000024013	1.67e-101	302.0	2D3IM@1|root,2SRQ0@2759|Eukaryota,3ANQ2@33154|Opisthokonta,3C1ER@33208|Metazoa,3DHG5@33213|Bilateria,48EEB@7711|Chordata,49AXK@7742|Vertebrata,3JNW0@40674|Mammalia,35UP0@314146|Euarchontoglires	33208|Metazoa	S	L1 transposable element dsRBD-like domain	L1TD1	-	-	-	-	-	-	-	-	-	-	-	Tnp_22_dsRBD,Tnp_22_trimer,Transposase_22
k59_71860_1	1278073.MYSTI_01928	7.77e-07	54.3	2EU1Z@1|root,33MJ0@2|Bacteria,1NN57@1224|Proteobacteria,432VE@68525|delta/epsilon subdivisions,2WY9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_311518_1	1395571.TMS3_0124685	3.4e-06	48.5	COG3193@1|root,COG3193@2|Bacteria,1RH9E@1224|Proteobacteria,1SAUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
k59_312513_2	570417.WP1247	2.51e-236	650.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria,47FPJ@766|Rickettsiales	766|Rickettsiales	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
k59_123461_1	7029.ACYPI008751-PA	0.0	1065.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_143524_1	7159.AAEL005015-PA	7.32e-178	530.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VPS@33154|Opisthokonta,3C5ZM@33208|Metazoa,3DM1B@33213|Bilateria,42CJJ@6656|Arthropoda,3STFX@50557|Insecta,4582J@7147|Diptera,45M6U@7148|Nematocera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_113489_1	436308.Nmar_0619	6.52e-67	210.0	arCOG03727@1|root,arCOG03727@2157|Archaea,41STD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
k59_213298_1	580332.Slit_2495	2.85e-44	149.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VPKX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome c-type protein	napC	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_213298_2	395495.Lcho_1552	8.45e-17	80.1	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
k59_94139_1	1236908.wNo_08910	1.11e-156	442.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,47ET1@766|Rickettsiales	766|Rickettsiales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_163908_4	1286106.MPL1_02031	0.000281	45.4	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,45ZTS@72273|Thiotrichales	72273|Thiotrichales	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
k59_163908_5	595537.Varpa_1992	4.51e-21	97.4	2ECJ7@1|root,336HA@2|Bacteria,1N1RH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_193514_1	570417.WP1033	4.33e-127	375.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,47FNZ@766|Rickettsiales	766|Rickettsiales	CP	COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	nuoL3	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
k59_223076_1	7994.ENSAMXP00000025636	6.1e-55	199.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,48D8K@7711|Chordata,490MU@7742|Vertebrata	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_94144_1	1175306.GWL_35780	3.09e-153	444.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,4726R@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_282754_1	335283.Neut_0917	2.7e-08	55.5	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
k59_282754_2	1532557.JL37_22745	1.05e-40	147.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,3T1U7@506|Alcaligenaceae	28216|Betaproteobacteria	D	peptidase	envC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
k59_3462_1	631454.N177_1875	4.47e-31	126.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	transport system fused permease components	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_232429_1	8128.ENSONIP00000026565	4.88e-26	111.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_293186_1	163164.WD_0509	1.23e-133	394.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,47F25@766|Rickettsiales	766|Rickettsiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
k59_263335_1	15368.BRADI4G04484.1	1.39e-77	267.0	COG2801@1|root,KOG0017@2759|Eukaryota,37V5Q@33090|Viridiplantae,3GFFK@35493|Streptophyta,3M7B5@4447|Liliopsida,3IKJW@38820|Poales	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,Retrotran_gag_3,gag_pre-integrs,rve,zf-CCHC
k59_3478_1	7029.ACYPI29234-PA	3.19e-43	160.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_153055_1	1236908.wNo_07660	1.36e-112	337.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,47EU9@766|Rickettsiales	766|Rickettsiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k59_72806_1	163164.WD_1041	5.51e-154	464.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	AXH,NADase_NGA
k59_84184_1	1122915.AUGY01000118_gene6532	6.63e-73	231.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575,ko:K08223	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.35,2.A.1.8	-	-	MFS_1
k59_94166_1	400682.PAC_15714283	1.2e-34	136.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_34109_1	7029.ACYPI071420-PA	1.47e-53	193.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa	33208|Metazoa	L	steroid hormone mediated signaling pathway	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_282773_1	339671.Asuc_2073	5.42e-15	72.4	COG0599@1|root,COG0599@2|Bacteria,1RH7V@1224|Proteobacteria,1S6K3@1236|Gammaproteobacteria,1YA96@135625|Pasteurellales	135625|Pasteurellales	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k59_282773_2	756067.MicvaDRAFT_3414	5.65e-26	98.6	COG2329@1|root,COG2329@2|Bacteria,1G7DQ@1117|Cyanobacteria,1HCG0@1150|Oscillatoriales	1117|Cyanobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
k59_200168_1	497965.Cyan7822_1513	1.09e-81	251.0	COG2326@1|root,COG2326@2|Bacteria,1G34U@1117|Cyanobacteria,3KH32@43988|Cyanothece	2|Bacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
k59_309769_1	1121861.KB899926_gene2583	4.21e-65	208.0	COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_3
k59_190161_1	859657.RPSI07_mp1475	1.89e-147	416.0	COG0262@1|root,COG0262@2|Bacteria,1MU1W@1224|Proteobacteria,2VHF9@28216|Betaproteobacteria,1K4BD@119060|Burkholderiaceae	28216|Betaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
k59_279806_1	570417.WP1103	1.56e-188	544.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,47EU2@766|Rickettsiales	766|Rickettsiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_210068_1	1054860.KB913030_gene164	0.000264	48.5	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
k59_593_1	1236908.wNo_02790	3.49e-130	378.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,47EWC@766|Rickettsiales	766|Rickettsiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_180156_1	570417.WP0492	1.99e-177	505.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,47FW6@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k59_601_1	221103.XP_007858443.1	2.07e-14	74.3	COG2801@1|root,KOG0017@2759|Eukaryota,38IC9@33154|Opisthokonta,3PK9F@4751|Fungi,3V9V6@5204|Basidiomycota,22CUJ@155619|Agaricomycetes	4751|Fungi	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_100319_1	330214.NIDE1937	3.25e-68	230.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
k59_140295_1	467661.RKLH11_4181	6.08e-103	305.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3ZHZV@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k59_239888_1	436308.Nmar_0804	6.67e-115	334.0	COG0092@1|root,arCOG04097@2157|Archaea,41SIM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
k59_140297_1	1236908.wNo_00950	6.28e-119	342.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,47F9Q@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
k59_160370_1	570417.WP1355	1.75e-246	680.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,OprD,Porin_4
k59_160370_2	1236908.wNo_10500	1.19e-262	724.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria,47FAJ@766|Rickettsiales	766|Rickettsiales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
k59_130432_1	1236908.wNo_02400	4.53e-79	248.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,47EW7@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_130432_2	570417.WP0668	7.96e-08	52.4	COG4886@1|root,COG4886@2|Bacteria,1NJBW@1224|Proteobacteria	1224|Proteobacteria	S	Type III effector protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6
k59_80593_1	420662.Mpe_A3264	5.01e-53	181.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_239897_1	1229909.NSED_08445	5.28e-112	336.0	COG0343@1|root,arCOG00989@2157|Archaea,41SF4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
k59_30631_1	436308.Nmar_0581	8.98e-126	370.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
k59_299790_1	10224.XP_002740782.1	3.25e-29	120.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,rve,zf-CCHC
k59_200237_1	1131814.JAFO01000001_gene3676	3.75e-35	130.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3F1EG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
k59_210794_1	1229909.NSED_09330	4.87e-120	347.0	COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.131	ko:K05934	ko00860,ko01100,map00860,map01100	-	R05180,R05809	RC00003,RC01293,RC03471	ko00000,ko00001,ko01000	-	-	-	TP_methylase
k59_91374_1	1122236.KB905141_gene1334	1.64e-33	132.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG4627@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,COG4627@2|Bacteria,1RBR3@1224|Proteobacteria,2VSKQ@28216|Betaproteobacteria,2KP39@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_51244_1	570417.WP1383	1.72e-154	455.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,47F21@766|Rickettsiales	766|Rickettsiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
k59_51244_2	570417.WP1382	7.92e-46	149.0	COG0858@1|root,COG0858@2|Bacteria,1PRXZ@1224|Proteobacteria,2V45H@28211|Alphaproteobacteria,47FSW@766|Rickettsiales	766|Rickettsiales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
k59_131233_1	757424.Hsero_2580	2.53e-89	285.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,473C8@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_300369_1	7260.FBpp0254607	1.54e-29	122.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_81383_1	1126627.BAWE01000004_gene4279	6.04e-113	356.0	2DUMH@1|root,33R9V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_150853_1	10224.XP_006822105.1	8.09e-44	161.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10577	ko03013,ko04064,ko04120,ko05206,map03013,map04064,map04120,map05206	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko04121	-	-	-	RVT_1
k59_131248_1	1459636.NTE_01618	7.69e-58	183.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
k59_150855_1	7159.AAEL015565-PA	1.75e-70	217.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VQT@33154|Opisthokonta,3C60G@33208|Metazoa,3DM2C@33213|Bilateria,4278Y@6656|Arthropoda,3SSMC@50557|Insecta,454TX@7147|Diptera,45JKE@7148|Nematocera	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_141022_1	13249.RPRC005728-PA	1.82e-19	99.4	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3EC30@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1,zf-CCHC
k59_141022_2	7029.ACYPI004757-PA	6.4e-194	605.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3ECWM@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_200903_1	7213.XP_004520233.1	1.58e-225	712.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_210821_1	436308.Nmar_1627	2.61e-73	243.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_290671_1	570417.WP1071	5.17e-107	319.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,47FBT@766|Rickettsiales	766|Rickettsiales	M	Nucleotidyl transferase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
k59_1257_1	370438.PTH_2026	7.29e-11	71.6	COG3039@1|root,COG3039@2|Bacteria,1TS6Q@1239|Firmicutes,24B6I@186801|Clostridia,260JJ@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_190968_1	1229909.NSED_01670	0.0	893.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_270747_1	2340.JV46_05690	2.59e-176	499.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	L COG2826 Transposase and inactivated derivatives, IS30 family	insI	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
k59_11331_1	247490.KSU1_C0231	5.03e-41	149.0	2CDQ7@1|root,2Z7KV@2|Bacteria,2J41Q@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_250706_1	395494.Galf_0971	5.06e-39	140.0	COG3547@1|root,COG3547@2|Bacteria,1P502@1224|Proteobacteria,2W9QQ@28216|Betaproteobacteria,44WNJ@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_161202_1	640081.Dsui_3059	1.85e-79	253.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales	206389|Rhodocyclales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_150880_1	1385935.N836_25645	1.92e-24	107.0	COG4191@1|root,COG4191@2|Bacteria,1G4IK@1117|Cyanobacteria,1HE50@1150|Oscillatoriales	1117|Cyanobacteria	T	Double sensory domain of two-component sensor kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
k59_61267_1	7260.FBpp0250341	7.13e-78	246.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_260821_1	1454004.AW11_03381	4.77e-85	271.0	COG3386@1|root,COG3386@2|Bacteria,1QW76@1224|Proteobacteria	1224|Proteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_171077_2	1268072.PSAB_03610	1.08e-26	107.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,26WSQ@186822|Paenibacillaceae	91061|Bacilli	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
k59_220784_1	7029.ACYPI52857-PA	3.82e-94	326.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_131312_2	1229909.NSED_08185	2.48e-33	117.0	COG2947@1|root,arCOG08640@2157|Archaea,41SK6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_290732_1	180281.CPCC7001_2735	4.21e-124	368.0	COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,22TNQ@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k59_121190_1	29760.VIT_07s0005g06030.t01	1.53e-49	181.0	COG2801@1|root,KOG0017@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta	35493|Streptophyta	O	Mitochondrial protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,Retrotran_gag_3,Retrotrans_gag,gag_pre-integrs,rve,zf-CCHC
k59_31498_1	1236908.wNo_09700	5.29e-79	239.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,47EVQ@766|Rickettsiales	766|Rickettsiales	G	Class II Aldolase and Adducin N-terminal domain	addA	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k59_51338_1	261292.Nit79A3_2953	4.25e-93	283.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria,373NG@32003|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_161252_1	7029.ACYPI29654-PA	1.2e-25	110.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3C5WU@33208|Metazoa,3DG3H@33213|Bilateria,422D9@6656|Arthropoda,3SR1F@50557|Insecta	33154|Opisthokonta	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_41442_1	331869.BAL199_23729	1.01e-19	90.9	COG2199@1|root,COG3706@2|Bacteria,1QZ3H@1224|Proteobacteria,2TY4B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
k59_300436_1	1048829.XP_002789010.1	5.33e-28	101.0	2DZEY@1|root,2S6ZB@2759|Eukaryota,3A8VS@33154|Opisthokonta,3P6ME@4751|Fungi,3QYNF@4890|Ascomycota	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_210889_1	1229909.NSED_09640	1.54e-111	331.0	COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
k59_121219_1	420662.Mpe_A3264	4.15e-45	160.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k59_11401_1	1229909.NSED_01525	4.99e-08	53.1	COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_11401_2	1131266.ARWQ01000010_gene28	3.69e-84	256.0	COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
k59_220841_1	1236908.wNo_05390	5.18e-64	200.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,47F7F@766|Rickettsiales	766|Rickettsiales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
k59_220841_2	570417.WP0875	1.72e-54	176.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,47FF5@766|Rickettsiales	766|Rickettsiales	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
k59_111298_1	400682.PAC_15714469	1.1e-15	77.8	KOG1075@1|root,KOG1075@2759|Eukaryota,3AU79@33154|Opisthokonta,3C4HP@33208|Metazoa	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_181088_1	1229909.NSED_05145	3.59e-91	275.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota	651137|Thaumarchaeota	HK	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
k59_101040_1	436308.Nmar_1421	2.34e-61	192.0	arCOG08772@1|root,arCOG08772@2157|Archaea,41SSX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_101040_2	1229909.NSED_07795	6.78e-15	72.8	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_125522_1	71139.XP_010034499.1	1.65e-54	195.0	COG2801@1|root,COG4299@1|root,KOG0017@2759|Eukaryota,KOG4683@2759|Eukaryota,37RKH@33090|Viridiplantae,3GGZK@35493|Streptophyta	35493|Streptophyta	L	strictosidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,RVT_3,Retrotrans_gag,rve
k59_25883_1	748247.AZKH_3391	6.97e-27	105.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,2KYMT@206389|Rhodocyclales	206389|Rhodocyclales	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
k59_36466_1	292415.Tbd_1520	2.88e-94	287.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,1KRDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
k59_255440_1	65093.PCC7418_1504	2.49e-89	275.0	COG0438@1|root,COG0438@2|Bacteria,1G13R@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_3,Glycos_transf_1
k59_284744_1	570417.WP0038	1.74e-35	139.0	COG1511@1|root,COG1511@2|Bacteria	2|Bacteria	Q	domain protein	CP_1016	-	-	ko:K01421	-	-	-	-	ko00000	-	-	-	Effector_1
k59_175705_1	1123377.AUIV01000009_gene2597	3.09e-96	301.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales	135614|Xanthomonadales	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_25889_1	27923.ML08883a-PA	7.64e-36	140.0	KOG0977@1|root,KOG1075@1|root,KOG0977@2759|Eukaryota,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_15841_1	7029.ACYPI27720-PA	2.01e-29	121.0	KOG1075@1|root,KOG4205@1|root,KOG1075@2759|Eukaryota,KOG4205@2759|Eukaryota,3AMG2@33154|Opisthokonta,3C09Q@33208|Metazoa,3DGSX@33213|Bilateria,41TX7@6656|Arthropoda,3SFZZ@50557|Insecta,3E9XK@33342|Paraneoptera	2759|Eukaryota	A	RNA recognition motif	-	GO:0000375,GO:0000377,GO:0000398,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006366,GO:0006396,GO:0006397,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0008380,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009299,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0010638,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031974,GO:0031981,GO:0032204,GO:0032206,GO:0032268,GO:0032270,GO:0032501,GO:0032774,GO:0032991,GO:0033043,GO:0033044,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0042162,GO:0042752,GO:0042789,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043487,GO:0043488,GO:0043565,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045893,GO:0045935,GO:0046483,GO:0046700,GO:0048511,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051054,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051338,GO:0051347,GO:0051972,GO:0051973,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097167,GO:0097659,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902680,GO:1903311,GO:1903506,GO:1903508,GO:1904353,GO:1904355,GO:1905661,GO:1905663,GO:1990904,GO:2000112,GO:2000278,GO:2000573,GO:2001141,GO:2001252	-	ko:K03102,ko:K14411,ko:K15502	ko03015,ko04320,map03015,map04320	-	-	-	ko00000,ko00001,ko01009,ko03019,ko03041,ko03400	-	-	-	Ank_2,Ank_4,OST-HTH,RRM_1,RVT_1
k59_46601_1	6500.XP_005089442.1	6.77e-24	112.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	ko:K10356	-	-	-	-	ko00000,ko01009,ko03036,ko04131,ko04147,ko04812	-	-	-	DUF4283,RVT_1,RVT_3,zf-RVT
k59_215679_1	330214.NIDE0547	7.45e-80	256.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k59_166427_1	1265505.ATUG01000001_gene4759	4.42e-47	172.0	COG0069@1|root,COG2218@1|root,COG0069@2|Bacteria,COG2218@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJJR@28221|Deltaproteobacteria,2MICM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Conserved region in glutamate synthase	-	-	2.1.1.21	ko:K22083	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_7,Fer4_9,GXGXG,Glu_syn_central,Glu_synthase
k59_36486_1	1236959.BAMT01000006_gene424	6.32e-52	182.0	COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria,2KMC6@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
k59_125546_1	7425.NV10089-PA	1.82e-15	81.6	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_255455_1	748247.AZKH_p0116	1.13e-21	87.4	COG3631@1|root,COG3631@2|Bacteria,1PT2G@1224|Proteobacteria,2WA86@28216|Betaproteobacteria,2KYWR@206389|Rhodocyclales	206389|Rhodocyclales	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
k59_234134_1	1236908.wNo_06340	2.87e-187	528.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,47FYZ@766|Rickettsiales	766|Rickettsiales	S	PmbA protein	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_186086_1	7213.XP_004520233.1	8.43e-112	363.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_5522_1	436308.Nmar_0865	1.34e-68	221.0	COG0436@1|root,arCOG01130@2157|Archaea	2157|Archaea	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_115475_1	626418.bglu_1g04970	1.02e-112	333.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1K06J@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
k59_104860_2	1286093.C266_08952	7.33e-21	93.6	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2VN2Z@28216|Betaproteobacteria,1K0WD@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_115478_1	27923.ML08883a-PA	3.53e-37	144.0	KOG0977@1|root,KOG1075@1|root,KOG0977@2759|Eukaryota,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa	33154|Opisthokonta	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,RVT_1
k59_265840_1	7029.ACYPI061330-PA	3.15e-79	269.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_125576_1	1000565.METUNv1_02882	1.12e-26	100.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria,2KWFU@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k59_125576_2	1288494.EBAPG3_2800	1.25e-78	236.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,37319@32003|Nitrosomonadales	28216|Betaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_15890_1	693746.OBV_21060	7.92e-09	58.5	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,2N6UH@216572|Oscillospiraceae	186801|Clostridia	S	NMT1-like family	bcsP	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_295520_1	7029.ACYPI000268-PA	7.89e-39	145.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_225542_1	762376.AXYL_04697	2.94e-85	270.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2W09W@28216|Betaproteobacteria,3T6CP@506|Alcaligenaceae	28216|Betaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
k59_275697_1	113395.AXAI01000002_gene5152	5.39e-48	161.0	COG1845@1|root,COG1845@2|Bacteria,1MXAB@1224|Proteobacteria,2TRFQ@28211|Alphaproteobacteria,3JTBK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase subunit III	coxO	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
k59_275697_2	1041139.KB902680_gene1411	4.3e-56	181.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2U0NA@28211|Alphaproteobacteria,4B7SY@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	oxidase, subunit	coxP	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
k59_46682_1	1229909.NSED_04970	7.34e-07	50.1	COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
k59_74573_1	436308.Nmar_0430	3.6e-82	249.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
k59_25976_1	1236908.wNo_02960	1.16e-104	330.0	COG3704@1|root,COG3704@2|Bacteria,1NIX6@1224|Proteobacteria,2UK4E@28211|Alphaproteobacteria,47F7M@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_5578_1	436308.Nmar_1177	1.88e-74	240.0	COG1164@1|root,arCOG04758@2157|Archaea,41S7J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M3	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_234185_1	1229909.NSED_04430	4.47e-97	288.0	COG1471@1|root,arCOG04093@2157|Archaea,41SIE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
k59_145737_1	570417.WP1130	7.08e-60	202.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	DUF349,FtsX,MacB_PCD,Mob_Pre
k59_104913_1	7176.CPIJ009034-PA	4.38e-75	258.0	2CXTS@1|root,2RZNF@2759|Eukaryota,3AM5G@33154|Opisthokonta,3CR49@33208|Metazoa,3E797@33213|Bilateria,42B9J@6656|Arthropoda,3T0P5@50557|Insecta,459F3@7147|Diptera,45KK2@7148|Nematocera	33208|Metazoa	O	Conserved hypothetical protein	-	-	-	-	-	-	-	-	-	-	-	-	SecA_DEAD
k59_275720_1	1236908.wNo_03520	2.15e-35	121.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UWYU@28211|Alphaproteobacteria,47GRM@766|Rickettsiales	766|Rickettsiales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
k59_275720_2	570417.WP0657	4.25e-96	284.0	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	4.3.1.19	ko:K01754,ko:K02990	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010	M00178,M00570	R00220,R00996	RC00418,RC02600	br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029	-	-	-	Ribosomal_S6
k59_175805_1	570417.WP0529	1.51e-170	486.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,47F27@766|Rickettsiales	766|Rickettsiales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
k59_175805_2	1236908.wNo_01950	1.09e-29	115.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,47FWN@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
k59_125595_6	1507.HMPREF0262_03468	1.15e-40	162.0	COG1783@1|root,COG1783@2|Bacteria,1TT85@1239|Firmicutes,24ETQ@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6
k59_66847_1	1144325.PMI22_05150	8.66e-28	106.0	COG2318@1|root,COG2318@2|Bacteria,1RHRP@1224|Proteobacteria,1SAVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
k59_66850_1	1236908.wNo_01750	4.92e-111	323.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,47F5X@766|Rickettsiales	766|Rickettsiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
k59_166541_1	983917.RGE_03970	1.33e-99	297.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,1KJEX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
k59_145751_1	1229909.NSED_01430	2.86e-106	320.0	COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_295562_3	1229909.NSED_06170	9.68e-06	45.4	COG0784@1|root,arCOG02391@2157|Archaea,41TB0@651137|Thaumarchaeota	651137|Thaumarchaeota	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
k59_74592_1	420324.KI912061_gene6249	6.52e-45	156.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CE	Dehydrogenase	-	-	1.1.1.42,1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73	ko:K00031,ko:K00052,ko:K07246	ko00020,ko00290,ko00480,ko00630,ko00650,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00630,map00650,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00432,M00535,M00740	R00215,R00267,R00268,R00994,R01751,R01899,R02545,R04426,R06180,R10052	RC00001,RC00084,RC00105,RC00114,RC00417,RC00594,RC00626,RC02801,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_74592_2	999541.bgla_1g36550	5.7e-26	104.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2VIJK@28216|Betaproteobacteria,1K0WV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	dehH	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
k59_104928_1	436308.Nmar_0915	6.67e-96	290.0	COG0133@1|root,arCOG01433@2157|Archaea,41S87@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_36607_1	570417.WP0774	8.1e-105	319.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
k59_225587_1	7070.TC001491-PA	7.57e-60	214.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_175829_1	570417.WP1235	5.46e-226	631.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,47EU6@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_115550_1	100901.wOo_08050	1.33e-47	159.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,47FFK@766|Rickettsiales	766|Rickettsiales	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,BPL_LplA_LipB_2
k59_115550_2	163164.WD_0969	2.35e-123	363.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,47EYV@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_145760_1	7091.BGIBMGA012836-TA	3.2e-09	63.5	2E7WW@1|root,2SEF2@2759|Eukaryota,39MWI@33154|Opisthokonta,3CPG4@33208|Metazoa,3E5M5@33213|Bilateria,42ANZ@6656|Arthropoda,3T025@50557|Insecta	33208|Metazoa	S	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_155217_1	1236908.wNo_02980	5.29e-36	135.0	COG3704@1|root,COG3704@2|Bacteria,1P76F@1224|Proteobacteria,2UW5H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	TrbL/VirB6 plasmid conjugal transfer protein	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_155217_2	570417.WP0600	1.36e-54	189.0	COG3704@1|root,COG3704@2|Bacteria,1P5RF@1224|Proteobacteria	1224|Proteobacteria	U	Conjugal transfer protein	virB6	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_125617_1	570417.WP0625	5.83e-113	345.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,47F2J@766|Rickettsiales	766|Rickettsiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_26005_1	7159.AAEL017004-PA	4.04e-31	131.0	KOG1864@1|root,KOG1864@2759|Eukaryota,38BB6@33154|Opisthokonta,3BEQW@33208|Metazoa,3CRNZ@33213|Bilateria,41YD9@6656|Arthropoda,3SFQD@50557|Insecta,4504Q@7147|Diptera,45GWW@7148|Nematocera	33208|Metazoa	O	Ubiquitin carboxyl-terminal hydrolase	USP46	GO:0000578,GO:0001662,GO:0002209,GO:0002682,GO:0002684,GO:0003002,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004843,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006950,GO:0006952,GO:0007275,GO:0007350,GO:0007351,GO:0007389,GO:0007610,GO:0007631,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008343,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009605,GO:0009636,GO:0009790,GO:0009798,GO:0009880,GO:0009893,GO:0009948,GO:0009952,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010469,GO:0010604,GO:0010628,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0016579,GO:0016787,GO:0019222,GO:0019538,GO:0019783,GO:0019941,GO:0022898,GO:0023051,GO:0023056,GO:0023057,GO:0030163,GO:0030534,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032228,GO:0032409,GO:0032412,GO:0032501,GO:0032502,GO:0032879,GO:0033555,GO:0034762,GO:0034765,GO:0035254,GO:0035255,GO:0035282,GO:0036211,GO:0036459,GO:0036477,GO:0040012,GO:0040017,GO:0042221,GO:0042493,GO:0042596,GO:0043025,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043269,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0045746,GO:0046677,GO:0048149,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048856,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050795,GO:0050804,GO:0050854,GO:0050856,GO:0050857,GO:0050862,GO:0050896,GO:0051049,GO:0051603,GO:0060004,GO:0060013,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0070013,GO:0070646,GO:0070647,GO:0071704,GO:0071947,GO:0090325,GO:0090326,GO:0097305,GO:0097458,GO:0097708,GO:0099177,GO:0099601,GO:0101005,GO:0140096,GO:1900449,GO:1901564,GO:1901565,GO:1901575,GO:1901700,GO:1904062,GO:2000311,GO:2001257	3.4.19.12	ko:K11842	-	-	-	-	ko00000,ko01000,ko01002,ko04121	-	-	-	UCH
k59_304360_1	1236908.wNo_02620	1.67e-58	183.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria	1224|Proteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_304360_2	1236908.wNo_02610	6.22e-43	145.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,47F5R@766|Rickettsiales	766|Rickettsiales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
k59_166571_1	279303.Q6J804_9CAUD	1.94e-58	205.0	4QG92@10239|Viruses,4R01K@35237|dsDNA viruses  no RNA stage,4QQ94@28883|Caudovirales,4QNAV@10699|Siphoviridae	10699|Siphoviridae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_275760_2	1131266.ARWQ01000009_gene942	1.82e-55	175.0	COG1308@1|root,arCOG04061@2157|Archaea,41SNN@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
k59_126909_1	1123230.ARQJ01000001_gene1096	2.65e-15	71.2	arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,4HFPA@91061|Bacilli,4GZG2@90964|Staphylococcaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_126909_2	113355.CM001775_gene3188	2.51e-29	105.0	2DNQR@1|root,32YKU@2|Bacteria,1G9K3@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_75541_1	7029.ACYPI071052-PA	1.32e-61	219.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3C5WI@33208|Metazoa,3DKYM@33213|Bilateria,423C1@6656|Arthropoda	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2
k59_256777_1	1565129.JSFF01000003_gene2149	5.93e-06	49.7	COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,1SZUE@1236|Gammaproteobacteria,2QASV@267890|Shewanellaceae	1236|Gammaproteobacteria	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
k59_305249_1	7029.ACYPI50571-PA	5.76e-07	57.4	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI50571-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_226988_1	570417.WP0681	4.27e-102	311.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,47EUN@766|Rickettsiales	766|Rickettsiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
k59_245222_2	570417.WP0629	2.64e-143	414.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,47EVT@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
k59_168876_1	7159.AAEL017299-PA	8.05e-125	391.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_286502_1	570417.WP0356	5.4e-214	634.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,47F1Y@766|Rickettsiales	766|Rickettsiales	E	NAD-specific glutamate dehydrogenase	gdhB	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_316650_1	1236908.wNo_03710	8.07e-165	469.0	COG3675@1|root,COG3675@2|Bacteria,1NICA@1224|Proteobacteria,2V40X@28211|Alphaproteobacteria,47FSS@766|Rickettsiales	766|Rickettsiales	I	Lipase (class 3)	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_3
k59_147700_1	7029.ACYPI49800-PA	2.06e-16	82.8	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_17960_1	1163617.SCD_n00002	8.77e-59	193.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
k59_17960_2	1094563.MCQ_00815	1.23e-24	102.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,48SZ7@772|Bartonellaceae	28211|Alphaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_188463_1	1236908.wNo_00760	1.09e-134	395.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,47EV8@766|Rickettsiales	766|Rickettsiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_127651_1	323848.Nmul_A0657	2.32e-121	351.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,371SG@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
k59_7453_1	164328.Phyra85518	2.36e-41	156.0	COG2801@1|root,KOG0017@2759|Eukaryota,3QH4V@4776|Peronosporales	4776|Peronosporales	L	GAG-pre-integrase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_198044_1	570417.WP0554	4.8e-142	446.0	COG0085@1|root,COG0086@1|root,COG0085@2|Bacteria,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,47ETY@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_316654_1	7176.CPIJ001145-PA	1.86e-23	109.0	KOG4193@1|root,KOG4193@2759|Eukaryota,39WZ5@33154|Opisthokonta,3BM8U@33208|Metazoa,3D5FM@33213|Bilateria,41VRK@6656|Arthropoda,3SGIA@50557|Insecta,4561G@7147|Diptera	33208|Metazoa	T	7 transmembrane receptor (Secretin family)	-	-	-	ko:K04599	-	-	-	-	ko00000,ko04030	-	-	-	7tm_2
k59_305739_1	570417.WP1051	1.21e-101	324.0	COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gram_pos_anchor,LRR_5,YSIRK_signal,YadA_anchor,YadA_head,YadA_stalk
k59_227808_1	1236908.wNo_04670	5.97e-99	291.0	COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,2U6J6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	biosynthesis protein	elbB	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
k59_207475_1	570417.WP1049	2.15e-25	105.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,47F48@766|Rickettsiales	766|Rickettsiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	AAA
k59_297705_1	7668.SPU_023240-tr	1.47e-11	71.2	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_17989_1	1236908.wNo_03320	6.5e-102	316.0	COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,47F23@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	virB4-2	-	-	ko:K03199	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagE_TrbE_VirB
k59_217815_1	570417.WP0496	5.46e-114	343.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,47EUT@766|Rickettsiales	766|Rickettsiales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
k59_198059_1	7159.AAEL018006-PA	1.53e-33	129.0	2F5TP@1|root,2T6V3@2759|Eukaryota,390YU@33154|Opisthokonta,3C6QH@33208|Metazoa,3DMPP@33213|Bilateria,42480@6656|Arthropoda,3STE5@50557|Insecta,457SD@7147|Diptera,45M2J@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_188493_1	436308.Nmar_0833	3.45e-151	436.0	COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_157022_1	1236908.wNo_09770	2.33e-83	267.0	COG0484@1|root,COG0666@1|root,COG0484@2|Bacteria,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	2.8.1.1,2.8.1.2	ko:K01011,ko:K06867,ko:K07114	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Ank_2,Ank_4,DUF3099,DnaJ,Rhodanese
k59_207488_1	570417.WP0390	1.43e-84	276.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47FE1@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2
k59_127690_1	7176.CPIJ019855-PA	4.43e-87	290.0	2CXTS@1|root,2RZNF@2759|Eukaryota,3AM5G@33154|Opisthokonta,3CR49@33208|Metazoa,3E797@33213|Bilateria,42B9J@6656|Arthropoda,3T0P5@50557|Insecta,459F3@7147|Diptera,45KK2@7148|Nematocera	33154|Opisthokonta	O	Conserved hypothetical protein	-	-	-	-	-	-	-	-	-	-	-	-	SecA_DEAD,VWA_2
k59_58554_1	7425.NV19075-PA	1.51e-59	218.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RRM_1,RVT_1,rve,zf-H2C2
k59_68985_1	640081.Dsui_1586	8.51e-100	305.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KU74@206389|Rhodocyclales	206389|Rhodocyclales	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
k59_58560_1	7425.NV30710-PA	3.71e-31	125.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_297730_1	436308.Nmar_0944	3.91e-170	489.0	COG1111@1|root,arCOG00872@2157|Archaea	2157|Archaea	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03703,ko:K10896	ko03420,ko03460,map03420,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
k59_157042_1	6334.EFV50041	2.53e-65	224.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_38816_1	580332.Slit_1269	2.86e-57	192.0	COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales	28216|Betaproteobacteria	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,PEGA
k59_48961_1	7425.NV18983-PA	1.04e-51	179.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_235804_1	1288494.EBAPG3_2070	6.16e-118	359.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,372BV@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_235804_2	1000565.METUNv1_01871	1.09e-46	152.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,2KWPQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
k59_235804_3	1288494.EBAPG3_2050	1.41e-40	134.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,373I5@32003|Nitrosomonadales	28216|Betaproteobacteria	K	PFAM Cold-shock protein, DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_99454_1	102107.XP_008226719.1	2.82e-23	100.0	COG5429@1|root,2QQGJ@2759|Eukaryota,37NT0@33090|Viridiplantae,3GAAC@35493|Streptophyta,4JK1W@91835|fabids	35493|Streptophyta	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
k59_117501_1	570417.WP0407	3.56e-112	359.0	COG0457@1|root,COG0666@1|root,COG1672@1|root,COG2931@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG1672@2|Bacteria,COG2931@2|Bacteria,1MWRF@1224|Proteobacteria,2U9VQ@28211|Alphaproteobacteria,47F2N@766|Rickettsiales	766|Rickettsiales	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5,GerE,NB-ARC,TPR_12,TPR_2,TPR_7,TPR_8
k59_127715_1	1121372.AULK01000003_gene208	4.79e-10	65.1	COG0715@1|root,COG0715@2|Bacteria,2GMEC@201174|Actinobacteria,4FM7U@85023|Microbacteriaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	NMT1
k59_268400_1	7425.NV23503-PA	5.69e-71	256.0	2CNQC@1|root,2QXFF@2759|Eukaryota,3AUJT@33154|Opisthokonta,3C4WG@33208|Metazoa,3DKWU@33213|Bilateria,42A2Q@6656|Arthropoda,3SZI4@50557|Insecta,46MYY@7399|Hymenoptera	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_177984_1	163164.WD_0566	7.48e-12	63.9	COG0666@1|root,COG0666@2|Bacteria,1N0BQ@1224|Proteobacteria,2UXW1@28211|Alphaproteobacteria,47GPI@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_4
k59_177984_2	570417.WP0355	2.27e-53	185.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,47EVZ@766|Rickettsiales	766|Rickettsiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k59_257644_1	6669.EFX62988	4.45e-27	106.0	2FHGI@1|root,2TIW3@2759|Eukaryota,3ABKB@33154|Opisthokonta,3C5MR@33208|Metazoa,3DCWC@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_257644_3	203908.EGF97272	4.87e-14	74.7	2DZJG@1|root,2S72Z@2759|Eukaryota,3ARBX@33154|Opisthokonta,3PFVH@4751|Fungi,3V65K@5204|Basidiomycota,2YG4K@29000|Pucciniomycotina	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_257644_5	2903.EOD13240	6.85e-05	42.7	2CZCW@1|root,2S9RN@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_48997_1	1236908.wNo_05230	1.79e-147	419.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,47F6N@766|Rickettsiales	766|Rickettsiales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
k59_209404_1	1236908.wNo_06470	6.29e-171	501.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,47EVS@766|Rickettsiales	766|Rickettsiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_158945_2	265072.Mfla_0079	4.13e-35	130.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,2KKSQ@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_209424_1	7159.AAEL017299-PA	7.19e-66	234.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_247768_1	1216976.AX27061_3155	8.52e-15	74.3	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,3T5NB@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	xsc	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_247768_2	631362.Thi970DRAFT_02282	8.15e-15	73.9	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,1SZTB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_9274_1	1122599.AUGR01000002_gene3514	6.5e-117	348.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RYJ7@1236|Gammaproteobacteria,1XNIW@135619|Oceanospirillales	135619|Oceanospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_77898_1	1502852.FG94_04245	7.78e-85	275.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,472B9@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
k59_307166_1	1236908.wNo_06450	2.23e-57	183.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,47FN2@766|Rickettsiales	766|Rickettsiales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
k59_108602_2	1095769.CAHF01000011_gene2526	4.64e-49	164.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VKIQ@28216|Betaproteobacteria,472K4@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	AAA domain	exeA2	-	-	ko:K02450,ko:K12283	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
k59_318885_1	76114.ebA2478	1.72e-112	334.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_108604_1	1236908.wNo_08570	6.53e-269	757.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,47F2B@766|Rickettsiales	766|Rickettsiales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_318919_1	1229909.NSED_00210	2.03e-67	218.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
k59_247845_1	436308.Nmar_0869	8.09e-66	216.0	COG0154@1|root,arCOG01717@2157|Archaea,41SCW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_159075_1	8081.XP_008423465.1	1.06e-52	177.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,48AQP@7711|Chordata,48YUZ@7742|Vertebrata	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_237434_1	1229909.NSED_08460	8.1e-91	277.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
k59_237434_2	436308.Nmar_1538	3.47e-23	89.4	arCOG08782@1|root,arCOG08782@2157|Archaea,41SVH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_307233_1	436308.Nmar_1066	1.41e-92	282.0	COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2,tRNA_anti-codon
k59_307233_2	1131266.ARWQ01000002_gene671	5.71e-45	154.0	COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_237438_1	7029.ACYPI004757-PA	7.35e-82	280.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3ECWM@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_9392_2	1443111.JASG01000004_gene2526	9.14e-11	62.8	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,3ZVZZ@60136|Sulfitobacter	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_29420	-	6.2.1.48	ko:K00666,ko:K02182	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_237464_1	6412.HelroP175615	1.56e-25	112.0	2CIKA@1|root,2S3RQ@2759|Eukaryota,3A5TG@33154|Opisthokonta,3BTMS@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RNase_H
k59_159132_1	570417.WP0356	2.22e-152	469.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,47F1Y@766|Rickettsiales	766|Rickettsiales	E	NAD-specific glutamate dehydrogenase	gdhB	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k59_281747_1	1123393.KB891332_gene2755	5.04e-47	163.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,1KSYA@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_82880_1	570417.WP0292	3.3e-77	258.0	COG0666@1|root,COG5635@1|root,COG0666@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,DUF4062,NACHT
k59_52612_1	1459636.NTE_03208	3.63e-104	321.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_172471_2	1469245.JFBG01000097_gene1349	1.71e-48	165.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
k59_252081_1	1229909.NSED_03385	1.16e-50	166.0	COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
k59_32910_1	309801.trd_0517	8.75e-11	63.2	COG2897@1|root,COG2897@2|Bacteria,2G8NA@200795|Chloroflexi,27Y2I@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
k59_32910_2	1229909.NSED_09015	1.64e-28	113.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
k59_272174_2	7070.TC011220-PA	2.27e-119	392.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve,zf-H2C2
k59_172476_1	7159.AAEL017299-PA	2.47e-61	214.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_52627_1	1236908.wNo_02880	5.21e-73	241.0	2DJHP@1|root,30663@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_132795_1	760568.Desku_3253	9.09e-28	119.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,248AI@186801|Clostridia,260EE@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_222126_1	1236908.wNo_02650	7.15e-137	405.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,47EWM@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_222126_2	1236908.wNo_02660	1.4e-09	55.8	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,47FAM@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_241478_1	648996.Theam_0628	4.59e-10	58.9	COG0347@1|root,COG0347@2|Bacteria,2G43N@200783|Aquificae	200783|Aquificae	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_241478_2	1120963.KB894493_gene2913	3.67e-08	56.2	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,2PZNH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the glutamate synthase family	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Glu_synthase,Rieske,zf-CDGSH
k59_192415_1	7176.CPIJ006540-PA	2.58e-89	295.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_142412_1	7029.ACYPI29831-PA	2.09e-40	152.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria	33208|Metazoa	J	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_71943_1	5059.CADAFLAP00013483	2.27e-109	326.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39SG3@33154|Opisthokonta,3P4RB@4751|Fungi	4751|Fungi	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_212209_1	436308.Nmar_0208	1.94e-18	82.0	COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
k59_212209_2	1131266.ARWQ01000008_gene324	5.31e-34	125.0	arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
k59_252106_1	1198452.Jab_1c04000	2.76e-91	273.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,473C7@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
k59_292108_1	7029.ACYPI52244-PA	5.15e-22	102.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_82951_1	1229909.NSED_00055	8.46e-180	509.0	COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Initiation factor	-	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
k59_102088_1	1236908.wNo_10390	5.58e-52	186.0	COG0210@1|root,COG0666@1|root,COG0210@2|Bacteria,COG0666@2|Bacteria,1R4JW@1224|Proteobacteria	1224|Proteobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,Ank_2,Ank_5,UvrD-helicase,UvrD_C,Viral_helicase1
k59_82959_2	1349767.GJA_5394	5.84e-32	125.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
k59_62641_1	1454004.AW11_03088	1.69e-54	180.0	2DB88@1|root,2Z7QT@2|Bacteria,1R0WJ@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
k59_252129_1	582744.Msip34_1754	1.11e-60	190.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KMW5@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
k59_222164_1	1236908.wNo_09990	6.94e-180	514.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,47EWW@766|Rickettsiales	766|Rickettsiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_12707_1	1300345.LF41_1929	2.56e-92	290.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales	135614|Xanthomonadales	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k59_311634_1	7176.CPIJ014372-PA	1.34e-25	105.0	COG5117@1|root,KOG2153@2759|Eukaryota,38C9J@33154|Opisthokonta,3BF7I@33208|Metazoa,3CUVW@33213|Bilateria,41XGK@6656|Arthropoda,3SI20@50557|Insecta,4507V@7147|Diptera,45J6Q@7148|Nematocera	33208|Metazoa	JU	CBF/Mak21 family	NOC3L	GO:0000981,GO:0003674,GO:0003682,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006355,GO:0006357,GO:0007275,GO:0007517,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016604,GO:0016607,GO:0019216,GO:0019219,GO:0019222,GO:0030154,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045444,GO:0048513,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061061,GO:0065007,GO:0070013,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K14834	-	-	-	-	ko00000,ko03009	-	-	-	CBF,NOC3p
k59_231627_1	1157490.EL26_19055	5.43e-47	164.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,278AK@186823|Alicyclobacillaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
k59_222175_1	570417.WP0229	3.4e-138	408.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,47EWH@766|Rickettsiales	766|Rickettsiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
k59_252137_1	1348657.M622_19215	4.33e-23	100.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VMVE@28216|Betaproteobacteria,2KWGY@206389|Rhodocyclales	206389|Rhodocyclales	L	IstB-like ATP binding N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
k59_102117_1	715451.ambt_12015	4.34e-38	135.0	2CBAE@1|root,32YK1@2|Bacteria,1N7NP@1224|Proteobacteria,1SGTK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_62661_1	570417.WP1194	4.05e-105	304.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,47FBI@766|Rickettsiales	766|Rickettsiales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
k59_62661_2	1236908.wNo_08510	3.13e-62	195.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,47EZW@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k59_172554_1	443598.AUFA01000133_gene3465	1.19e-09	58.5	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,2TTWJ@28211|Alphaproteobacteria,3JUQG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
k59_223182_1	948106.AWZT01000053_gene1580	1.46e-59	196.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,1K09J@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Cysteine desulfurase	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
k59_223182_2	686340.Metal_1185	2.98e-08	52.8	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1XF3J@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM SUF system FeS	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k59_102979_1	1131266.ARWQ01000009_gene921	5.88e-109	339.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
k59_263457_1	1229204.AMYY01000018_gene2211	2.06e-29	113.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,4BSKE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycine zipper	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
k59_173659_1	570417.WP0081	2.97e-152	431.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,47EXI@766|Rickettsiales	766|Rickettsiales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
k59_173659_2	163164.WD_0301	3.27e-172	491.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,47EY0@766|Rickettsiales	766|Rickettsiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
k59_53889_1	394.NGR_c35870	1.05e-160	469.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k59_44248_1	1122135.KB893134_gene3480	4.94e-64	210.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein containing von Willebrand factor type A (VWA) domain	MA20_09405	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_72887_1	62928.azo3119	2.77e-82	254.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,2KV7H@206389|Rhodocyclales	206389|Rhodocyclales	I	Desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_302518_1	1380394.JADL01000010_gene4187	2.99e-24	102.0	COG1574@1|root,COG1574@2|Bacteria,1QVE6@1224|Proteobacteria,2TSU6@28211|Alphaproteobacteria,2JV4I@204441|Rhodospirillales	204441|Rhodospirillales	S	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
k59_302518_2	148304.MAPG_04495T0	2.22e-19	89.4	COG1804@1|root,KOG3957@2759|Eukaryota,39K31@33154|Opisthokonta,3Q4FZ@4751|Fungi,3RMNX@4890|Ascomycota,21QPN@147550|Sordariomycetes,41PHJ@639021|Magnaporthales	4751|Fungi	I	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA,CoA_transf_3,DUF4387
k59_193624_1	7029.ACYPI35745-PA	1.91e-92	326.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D7RZ@33213|Bilateria,422E1@6656|Arthropoda,3SQZA@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_53906_2	7029.ACYPI29951-PA	1.21e-41	161.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_263486_1	1116472.MGMO_224c00010	4.63e-10	57.4	2A022@1|root,30N4C@2|Bacteria,1PU9F@1224|Proteobacteria,1SCMU@1236|Gammaproteobacteria,1XFRM@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
k59_263486_2	1380394.JADL01000002_gene1439	1.43e-58	195.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VC6K@28211|Alphaproteobacteria,2JXZZ@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_183796_1	7029.ACYPI26074-PA	1.11e-10	68.9	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
k59_43753_2	1254432.SCE1572_47310	3.93e-64	208.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
k59_123173_1	1254432.SCE1572_16030	8.2e-39	143.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
k59_13326_1	570417.WP0025	3.91e-172	481.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,47FJD@766|Rickettsiales	766|Rickettsiales	S	Belongs to the GcvT family	gcvT	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
k59_302120_1	395493.BegalDRAFT_2522	2.06e-42	155.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,462J7@72273|Thiotrichales	72273|Thiotrichales	T	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k59_212963_1	472175.EL18_02586	5.65e-46	159.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,43HCS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	MA20_14330	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_203071_1	330214.NIDE3315	1.42e-52	178.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Cu_amine_oxidN1,F5_F8_type_C,IgGFc_binding,PKD
k59_123188_1	27923.ML39111a-PA	8.82e-09	64.3	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	2.3.2.8	ko:K00685	-	-	R03862	RC00055,RC00064	ko00000,ko01000,ko03016	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1,zf-RVT
k59_13331_1	983917.RGE_31350	1.75e-31	117.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,1KNX0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_262991_1	1411123.JQNH01000001_gene3814	3.56e-59	193.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TV99@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the citrate synthase family	prpC	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_262991_2	1227457.C451_09285	2.13e-16	78.2	COG0280@1|root,arCOG00855@2157|Archaea,2Y7FX@28890|Euryarchaeota,241GM@183963|Halobacteria	183963|Halobacteria	C	Phosphate acetyl/butaryl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
k59_72560_1	7029.ACYPI061287-PA	1.19e-36	143.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_3166_1	657322.FPR_04900	3.31e-06	54.3	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,3WIR8@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
k59_173210_1	290400.Jann_1557	6.36e-16	84.0	COG2340@1|root,COG5549@1|root,COG2340@2|Bacteria,COG5549@2|Bacteria,1R62B@1224|Proteobacteria,2U3MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF4214
k59_152749_1	1131266.ARWQ01000006_gene253	7.03e-56	186.0	COG0652@1|root,arCOG04767@2157|Archaea	2157|Archaea	G	Peptidyl-prolyl cis-trans isomerase	ppiA	-	2.4.99.18,5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K07151	ko00510,ko00513,ko01100,ko01503,ko04141,ko04217,map00510,map00513,map01100,map01503,map04141,map04217	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003,ko03110,ko04147	-	GT66	-	Pro_isomerase
k59_102665_1	1229909.NSED_05420	2.33e-70	235.0	COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Pyruvate phosphate dikinase	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_163596_1	261292.Nit79A3_0139	1.73e-90	279.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,372CM@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Domain of unknown function DUF21	corB	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
k59_302150_1	436308.Nmar_0495	2.17e-123	363.0	COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
k59_113233_1	402881.Plav_3170	1.04e-48	166.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria,2TRZX@28211|Alphaproteobacteria,1JPMJ@119043|Rhodobiaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
k59_43827_1	7070.TC016329-PA	1.01e-60	213.0	COG2801@1|root,KOG0017@2759|Eukaryota,3AI6P@33154|Opisthokonta,3BYHH@33208|Metazoa,3DF0A@33213|Bilateria,422AK@6656|Arthropoda,3SZ6I@50557|Insecta	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_53458_1	61853.ENSNLEP00000023819	1.01e-212	619.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39RKB@33154|Opisthokonta,3BK61@33208|Metazoa,3E43G@33213|Bilateria,48JXY@7711|Chordata,49GK2@7742|Vertebrata,3JJ5B@40674|Mammalia,35U9R@314146|Euarchontoglires	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1725,Exo_endo_phos,Exo_endo_phos_2,RVT_1
k59_173237_1	240016.ABIZ01000001_gene1102	5.77e-15	78.6	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_203132_1	7159.AAEL017571-PA	1.3e-37	144.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_83818_1	94624.Bpet4717	5.61e-54	181.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,3T21B@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_183338_1	330214.NIDE3269	2.12e-139	404.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k59_93865_1	570417.WP0577	1.52e-67	214.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,47EWC@766|Rickettsiales	766|Rickettsiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
k59_93865_2	1236908.wNo_02800	2.79e-54	171.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,47FH5@766|Rickettsiales	766|Rickettsiales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
k59_102696_1	1288494.EBAPG3_2800	1.56e-72	220.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,37319@32003|Nitrosomonadales	28216|Betaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k59_123264_1	1236908.wNo_02670	9.18e-83	244.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,47FAT@766|Rickettsiales	766|Rickettsiales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k59_123264_2	570417.WP0563	2.29e-50	162.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,47FAM@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k59_123265_1	118173.KB235914_gene571	2.89e-23	93.2	2C3ZQ@1|root,32SCF@2|Bacteria,1G6WP@1117|Cyanobacteria,1HBQW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM MEKHLA domain	-	-	-	-	-	-	-	-	-	-	-	-	MEKHLA
k59_143292_1	7425.NV15392-PA	2.31e-39	160.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_83848_1	7029.ACYPI068208-PA	2.72e-32	127.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_242113_2	1173020.Cha6605_1518	5.07e-10	56.6	COG1917@1|root,COG1917@2|Bacteria,1G7K6@1117|Cyanobacteria	1117|Cyanobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k59_72619_1	570417.WP0954	6.05e-137	391.0	COG0457@1|root,COG0457@2|Bacteria,1NFUY@1224|Proteobacteria,2UJ0M@28211|Alphaproteobacteria,47GU8@766|Rickettsiales	766|Rickettsiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
k59_152806_1	1459636.NTE_00962	1.62e-41	139.0	arCOG10586@1|root,arCOG10586@2157|Archaea,41STH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_13437_1	1229909.NSED_06420	3.35e-79	242.0	COG3467@1|root,arCOG00520@2157|Archaea,41SJ5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
k59_312306_1	269482.Bcep1808_3229	3.45e-22	109.0	COG3941@1|root,COG5283@1|root,COG3941@2|Bacteria,COG5283@2|Bacteria,1R5FU@1224|Proteobacteria,2VPNW@28216|Betaproteobacteria,1K6D9@119060|Burkholderiaceae	28216|Betaproteobacteria	D	tape measure	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_312306_5	1370122.JHXQ01000018_gene71	1.48e-27	107.0	2E1AD@1|root,32WQE@2|Bacteria,1N38M@1224|Proteobacteria,2UDR6@28211|Alphaproteobacteria,4BG8C@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Bacteriophage HK97-gp10, putative tail-component	-	-	-	-	-	-	-	-	-	-	-	-	HK97-gp10_like
k59_183368_1	164328.Phyra85518	7.85e-27	112.0	COG2801@1|root,KOG0017@2759|Eukaryota,3QH4V@4776|Peronosporales	4776|Peronosporales	L	GAG-pre-integrase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_242126_1	330214.NIDE1361	2.79e-32	114.0	COG0347@1|root,COG0347@2|Bacteria,3J0P1@40117|Nitrospirae	40117|Nitrospirae	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
k59_213075_1	1131266.ARWQ01000001_gene1081	2.39e-77	241.0	COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_242128_1	1499967.BAYZ01000077_gene879	1.54e-60	194.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k59_43898_1	570417.WP0802	8.43e-73	221.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,47FDN@766|Rickettsiales	766|Rickettsiales	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
k59_102726_1	570417.WP0625	1.54e-95	300.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,47F2J@766|Rickettsiales	766|Rickettsiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_43916_1	570417.WP0730	4.77e-79	247.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_222881_1	436308.Nmar_0115	6.84e-159	458.0	COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_252984_1	570417.WP0786	7.64e-76	234.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,47ET7@766|Rickettsiales	766|Rickettsiales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_252984_2	570417.WP0787	7.64e-24	100.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Cu_amine_oxidN1
k59_203213_1	570417.WP0175	3.47e-63	214.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,47ETW@766|Rickettsiales	766|Rickettsiales	L	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	recB	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_203213_2	1236908.wNo_09820	1.1e-72	224.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,47FHY@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
k59_293002_1	436308.Nmar_1109	5.48e-128	372.0	COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
k59_43921_1	570417.WP1122	3.53e-205	567.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria,47EVV@766|Rickettsiales	766|Rickettsiales	J	glycyl-tRNA synthetase, alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
k59_43921_2	570417.WP1121	3.04e-17	80.1	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,47F1H@766|Rickettsiales	766|Rickettsiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
k59_214137_2	1157708.KB907462_gene897	9.38e-38	139.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,4AB2U@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
k59_194254_1	7213.XP_004520233.1	3.06e-205	620.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_293961_1	436308.Nmar_1177	2.45e-91	284.0	COG1164@1|root,arCOG04758@2157|Archaea,41S7J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M3	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
k59_85039_1	1463845.JOIG01000016_gene1348	1.22e-06	53.1	COG0031@1|root,COG0031@2|Bacteria,2GK6J@201174|Actinobacteria	201174|Actinobacteria	E	cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_114214_2	519989.ECTPHS_14004	2.25e-226	634.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales	135613|Chromatiales	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_124363_2	7425.NV31842-PA	3.67e-39	143.0	2F3G8@1|root,2T4FJ@2759|Eukaryota,38Y72@33154|Opisthokonta,3C5TK@33208|Metazoa,3DM4J@33213|Bilateria,42320@6656|Arthropoda	7425.NV31842-PA|-	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_14630_1	1229909.NSED_07020	1.89e-102	301.0	arCOG08717@1|root,arCOG08717@2157|Archaea,41SFQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
k59_274386_1	570417.WP0182	8.24e-155	449.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,47ETE@766|Rickettsiales	766|Rickettsiales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
k59_303253_1	340099.Teth39_2019	6.57e-31	113.0	COG0864@1|root,COG0864@2|Bacteria,1V5TB@1239|Firmicutes,24HRD@186801|Clostridia,42G9E@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
k59_303253_2	330214.NIDE0690	1.84e-71	234.0	COG4772@1|root,COG4772@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
k59_135132_1	7070.TC004225-PA	1.89e-25	112.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_114376_2	384765.SIAM614_09068	1.44e-09	55.5	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2U5SV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	endoribonuclease L-PSP	MA20_29855	-	-	ko:K09021	ko00240,ko01100,map00240,map01100	-	R09982	RC02768	ko00000,ko00001	-	-	-	Ribonuc_L-PSP
k59_73573_1	1236908.wNo_05850	1.75e-110	320.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,2U6AD@28211|Alphaproteobacteria,47FGV@766|Rickettsiales	766|Rickettsiales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
k59_73573_2	1236908.wNo_05860	3.35e-91	270.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,47F9E@766|Rickettsiales	766|Rickettsiales	O	Glutathione S-transferase	gst	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_C_3,GST_N_3
k59_45218_1	1131266.ARWQ01000001_gene1199	1.08e-64	208.0	COG1361@1|root,arCOG02080@2157|Archaea	2157|Archaea	M	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
k59_14644_1	7245.FBpp0263216	3.81e-39	145.0	29FK7@1|root,2RNRY@2759|Eukaryota,38SFN@33154|Opisthokonta,3CD42@33208|Metazoa,3DUEZ@33213|Bilateria,42BUU@6656|Arthropoda,3SSBZ@50557|Insecta,457Q0@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_4400_1	1000565.METUNv1_02405	1.86e-37	140.0	COG2114@1|root,COG2114@2|Bacteria,1QWGZ@1224|Proteobacteria,2WEJJ@28216|Betaproteobacteria,2KZV9@206389|Rhodocyclales	206389|Rhodocyclales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
k59_214410_1	1005962.W1QI12	3.33e-16	80.9	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3QNZW@4890|Ascomycota,3RTT4@4891|Saccharomycetes	4751|Fungi	L	retrotransposon	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_4402_1	1123487.KB892840_gene33	5.57e-40	147.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KUR5@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_73577_1	570417.WP0881	1.59e-145	409.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,47FEZ@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
k59_114390_1	7029.ACYPI062548-PA	4.27e-47	172.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T00U@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_144484_1	716928.AJQT01000058_gene5362	1.43e-19	88.2	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,4BMWI@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_254235_1	570417.WP1169	5.64e-162	455.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,47EZ2@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_254235_2	1236908.wNo_08240	6.88e-58	179.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,47FMH@766|Rickettsiales	766|Rickettsiales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
k59_153967_1	62928.azo0988	1.36e-69	224.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales	206389|Rhodocyclales	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
k59_35195_1	570417.WP1069	5.6e-76	227.0	COG2142@1|root,COG2142@2|Bacteria	2|Bacteria	C	succinate dehydrogenase activity	sdhD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
k59_124385_1	172088.AUGA01000207_gene355	5.95e-54	182.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,3JT38@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG4584 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_103799_1	323848.Nmul_A0706	1.01e-110	324.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,2VRMX@28216|Betaproteobacteria,371UR@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k59_103799_2	1163617.SCD_n01755	2.03e-56	185.0	COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,2VKEP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	polysaccharide deacetylase	arnD	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
k59_214429_1	436308.Nmar_1104	6.2e-249	709.0	COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota	651137|Thaumarchaeota	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_135176_1	436308.Nmar_0578	5.08e-93	287.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
k59_65181_1	570417.WP0871	3.44e-140	398.0	COG3504@1|root,COG3504@2|Bacteria,1MVEF@1224|Proteobacteria,2U90J@28211|Alphaproteobacteria,47F7Y@766|Rickettsiales	766|Rickettsiales	U	Type IV secretory pathway, VirB9 components	trbG	-	-	ko:K03204	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagX
k59_65181_2	570417.WP0870	6.58e-119	341.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,47FCU@766|Rickettsiales	766|Rickettsiales	J	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
k59_214439_1	7070.TC010625-PA	3.02e-28	118.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X6K@33154|Opisthokonta,3BK4A@33208|Metazoa,3CYZ9@33213|Bilateria,41X3S@6656|Arthropoda,3SHIN@50557|Insecta	33208|Metazoa	S	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_24673_1	570417.WP0642	2.74e-85	267.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,47EUI@766|Rickettsiales	766|Rickettsiales	E	COG0006 Xaa-Pro aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_85341_1	570417.WP0031	5.04e-78	239.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,SLH,Sel1
k59_24681_1	592029.DDD_0039	2.99e-05	51.2	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HYQF@117743|Flavobacteriia	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
k59_294275_1	1229909.NSED_04395	1.43e-25	96.7	arCOG11516@1|root,arCOG11516@2157|Archaea,41T9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_294275_2	436308.Nmar_0792	1.8e-14	67.4	arCOG08711@1|root,arCOG08711@2157|Archaea,41T4I@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_4462_1	1163408.UU9_16341	2.19e-34	135.0	COG0860@1|root,COG3188@1|root,COG0860@2|Bacteria,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,1RNWK@1236|Gammaproteobacteria,1X3RZ@135614|Xanthomonadales	135614|Xanthomonadales	NU	outer membrane usher protein	fasD	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	PapC_C,Usher
k59_135210_1	10689.H9C0B4_BPCPT	1.16e-94	309.0	4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses  no RNA stage,4QPQ9@28883|Caudovirales	28883|Caudovirales	S	N-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_73623_1	261292.Nit79A3_0883	3.93e-46	165.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,371YV@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_35245_1	570417.WP0617	8.95e-38	139.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,47EWY@766|Rickettsiales	766|Rickettsiales	I	Propionyl-CoA carboxylase alpha	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_35245_2	1236908.wNo_03150	8.32e-91	274.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,47F5S@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
k59_254292_1	5059.CADAFLAP00013483	1.3e-31	126.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39SG3@33154|Opisthokonta,3P4RB@4751|Fungi	4751|Fungi	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_14723_1	7029.ACYPI26074-PA	2.26e-10	68.2	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
k59_73629_1	1408164.MOLA814_00286	2.81e-08	56.2	COG4877@1|root,COG4877@2|Bacteria,1NNE2@1224|Proteobacteria,2VZ2F@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_303344_1	365044.Pnap_3755	1.99e-86	285.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,4AAEC@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_65245_1	163164.WD_0699	1.94e-29	112.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,47ET7@766|Rickettsiales	766|Rickettsiales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
k59_65245_2	1236908.wNo_04470	6.06e-61	193.0	2FHEY@1|root,34991@2|Bacteria,1P32Q@1224|Proteobacteria,2UUMG@28211|Alphaproteobacteria,47GGR@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_14725_1	1229909.NSED_09210	1.26e-48	161.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
k59_14725_2	436308.Nmar_1731	2.45e-31	119.0	COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
k59_103860_1	717785.HYPMC_3227	6.4e-89	277.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
k59_46394_1	570417.WP0086	3.53e-183	512.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,47EV5@766|Rickettsiales	766|Rickettsiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
k59_265565_1	436308.Nmar_1055	5.62e-83	259.0	COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota	651137|Thaumarchaeota	L	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_175518_1	1288494.EBAPG3_24440	1.86e-77	243.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,371V7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
k59_215462_2	582744.Msip34_0082	1.17e-55	186.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,2KKSQ@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
k59_74376_1	570417.WP1385	1.74e-147	444.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,47EX4@766|Rickettsiales	766|Rickettsiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrD	-	-	ko:K03296,ko:K18138,ko:K18989	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718,M00720	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.30	-	-	ACR_tran
k59_86373_1	999541.bgla_1g30200	8.37e-85	261.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2VJ99@28216|Betaproteobacteria,1K1C0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
k59_5330_1	436308.Nmar_0443	2.36e-45	154.0	COG1146@1|root,arCOG04548@2157|Archaea,41SH5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_5330_2	1131266.ARWQ01000010_gene48	6.73e-180	520.0	COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
k59_66494_1	7029.ACYPI54718-PA	2.72e-36	145.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_205304_1	595460.RRSWK_00869	4.46e-65	218.0	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k59_136366_1	1121374.KB891576_gene724	4.84e-16	78.2	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_195533_1	1123072.AUDH01000001_gene2763	6.67e-19	87.8	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_225266_1	7029.ACYPI005556-PA	1.91e-07	59.3	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXBC@33208|Metazoa,3DBAC@33213|Bilateria,421D4@6656|Arthropoda,3SR4B@50557|Insecta,3ED43@33342|Paraneoptera	33154|Opisthokonta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_25739_1	570417.WP0782	1.34e-159	481.0	COG1061@1|root,COG1061@2|Bacteria	2|Bacteria	L	Type III restriction enzyme res subunit	-	GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF3427,DUF3854,Helicase_C,ResIII
k59_46436_1	1229909.NSED_09040	3.07e-97	297.0	COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k59_185890_1	324057.Pjdr2_3432	4.96e-45	164.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4HAQD@91061|Bacilli,26RK0@186822|Paenibacillaceae	91061|Bacilli	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
k59_154960_1	1123073.KB899241_gene3104	2.4e-30	117.0	COG3386@1|root,COG3386@2|Bacteria,1RAZC@1224|Proteobacteria,1S89J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Senescence marker protein-30 family protein	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
k59_195561_1	436308.Nmar_1712	1.71e-97	297.0	COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota	651137|Thaumarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_56100_1	556268.OFAG_02109	9.98e-65	211.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,476TX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	CoA-transferase family III	-	-	2.8.3.16,2.8.3.22	ko:K07749,ko:K14471,ko:K14472	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R00406,R03154	RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
k59_96649_1	31234.CRE08564	3.63e-29	122.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,414R4@6236|Rhabditida	33208|Metazoa	L	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC
k59_25763_1	570417.WP0065	4.66e-52	171.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,SLH,Sel1
k59_44153_1	1236908.wNo_07970	6.46e-122	357.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,47EW1@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
k59_44153_2	163164.WD_0132	4.07e-62	199.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,47EY7@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
k59_273339_1	570417.WP0087	1.61e-115	343.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,47EW2@766|Rickettsiales	766|Rickettsiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
k59_53807_1	1236908.wNo_07840	8.51e-96	300.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,47EU2@766|Rickettsiales	766|Rickettsiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_223116_1	1229909.NSED_02620	7.92e-87	260.0	COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota	651137|Thaumarchaeota	K	segregation and condensation protein	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
k59_223116_2	1229909.NSED_02615	8.63e-24	93.2	COG2007@1|root,arCOG04154@2157|Archaea,41SP2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
k59_273347_2	436308.Nmar_0071	7.99e-59	186.0	COG2125@1|root,arCOG01946@2157|Archaea,41SPC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
k59_253233_1	1229909.NSED_09785	3.61e-06	49.7	arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_253233_2	1131266.ARWQ01000001_gene1337	2.62e-10	56.6	COG3432@1|root,arCOG01055@2157|Archaea,41T3P@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
k59_53828_1	1266925.JHVX01000002_gene1081	6.48e-09	57.4	COG3073@1|root,COG3073@2|Bacteria,1QANZ@1224|Proteobacteria,2VVPR@28216|Betaproteobacteria,373CP@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Anti sigma-E protein RseA, N-terminal domain	rseA	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
k59_53828_2	395494.Galf_1186	1.73e-13	71.2	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,44V1A@713636|Nitrosomonadales	28216|Betaproteobacteria	T	MucB/RseB C-terminal domain	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
k59_273353_1	570417.WP0482	6.62e-308	850.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,47EZA@766|Rickettsiales	766|Rickettsiales	L	ATP-dependent DNA helicase (RecG)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
k59_213386_1	1286631.X805_11760	1.63e-46	159.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1KJVK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
k59_213386_2	398578.Daci_5349	1.45e-31	115.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,4AB1P@80864|Comamonadaceae	28216|Betaproteobacteria	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_134079_1	7260.FBpp0250341	9.34e-60	197.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_312596_1	335283.Neut_0857	4.23e-29	112.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,3724C@32003|Nitrosomonadales	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_312596_2	1123392.AQWL01000001_gene1551	3.11e-07	52.4	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1KRGM@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_183711_1	436308.Nmar_0284	2.99e-112	338.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_183711_2	436308.Nmar_0283	1.45e-19	80.9	COG0713@1|root,arCOG03073@2157|Archaea,41SPM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K)	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
k59_282826_1	163164.WD_1246	1.04e-26	102.0	COG0546@1|root,COG0546@2|Bacteria,1RDW2@1224|Proteobacteria,2U7C9@28211|Alphaproteobacteria,47FFM@766|Rickettsiales	766|Rickettsiales	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
k59_282826_2	1236908.wNo_09510	4.77e-92	271.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k59_173619_1	1236908.wNo_02030	2.59e-125	363.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2V4N3@28211|Alphaproteobacteria,47FYJ@766|Rickettsiales	766|Rickettsiales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_44223_1	570417.WP0546	6.14e-51	172.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,GvpL_GvpF
k59_44223_2	570417.WP0545	6.97e-94	277.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,47F6C@766|Rickettsiales	766|Rickettsiales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
k59_94240_1	570417.WP0931	1.59e-122	350.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,47FC5@766|Rickettsiales	766|Rickettsiales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
k59_123596_1	436308.Nmar_1628	2.67e-224	638.0	COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota	651137|Thaumarchaeota	FK	Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,HTH_20,NRDD
k59_123596_2	1229909.NSED_08885	1.64e-07	50.1	COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota	651137|Thaumarchaeota	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
k59_193614_1	243233.MCA3000	1.83e-90	289.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales	135618|Methylococcales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
k59_282836_1	570417.WP0667	0.0	890.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,47EUQ@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_53883_1	713587.THITH_01405	3.61e-21	90.5	2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_53883_2	1049564.TevJSym_at00740	4.1e-25	100.0	COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
k59_143657_1	7159.AAEL017990-PA	5.39e-58	190.0	2D5GH@1|root,2SYGV@2759|Eukaryota,3ASKA@33154|Opisthokonta,3C478@33208|Metazoa,3DJV7@33213|Bilateria,423NM@6656|Arthropoda,3SXI7@50557|Insecta,459TE@7147|Diptera,45KYV@7148|Nematocera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-CCHC
k59_72877_1	1236908.wNo_09940	6.33e-87	263.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,47EZ9@766|Rickettsiales	766|Rickettsiales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_194760_1	570417.WP0609	4.98e-198	555.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,47FC3@766|Rickettsiales	766|Rickettsiales	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k59_165321_1	1144307.PMI04_03066	2.32e-51	172.0	COG3618@1|root,COG3618@2|Bacteria,1R3QY@1224|Proteobacteria,2U493@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
k59_144735_1	436308.Nmar_0472	1.95e-31	123.0	COG0640@1|root,arCOG01686@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
k59_274687_2	1229909.NSED_03725	1.61e-43	142.0	arCOG10537@1|root,arCOG10537@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_65517_1	570417.WP0669	1.15e-248	689.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,47EW7@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
k59_185050_1	7260.FBpp0254607	8.48e-47	172.0	2EHYS@1|root,2SNHA@2759|Eukaryota,3AJQG@33154|Opisthokonta,3BZQ5@33208|Metazoa,3DG82@33213|Bilateria,422DB@6656|Arthropoda,3SR1G@50557|Insecta,454HA@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759
k59_124637_1	1454004.AW11_03085	3.38e-138	413.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k59_165336_1	62928.azo1901	1.44e-78	255.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
k59_243356_1	570417.WP1092	9.85e-197	555.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,47F0A@766|Rickettsiales	766|Rickettsiales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
k59_283925_1	7159.AAEL005642-PA	9.6e-44	159.0	2E0WI@1|root,2S89W@2759|Eukaryota,397E2@33154|Opisthokonta,3CBQ5@33208|Metazoa,3DSZQ@33213|Bilateria,424KF@6656|Arthropoda,3STV6@50557|Insecta,45B4K@7147|Diptera,45KZ8@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_135467_2	1454004.AW11_00197	1.13e-17	79.7	2ER05@1|root,33IJN@2|Bacteria,1NNPP@1224|Proteobacteria,2W6EF@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_174832_1	436308.Nmar_0318	1.76e-41	137.0	COG1644@1|root,arCOG04244@2157|Archaea,41SPN@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
k59_95709_1	281687.CJA36463	1.06e-17	93.2	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_254538_1	1472716.KBK24_0127780	1.17e-35	133.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1K0G2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_73815_1	243230.DR_2425	1.37e-22	96.7	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_33
k59_35484_1	756272.Plabr_0991	1.7e-14	72.0	COG0137@1|root,COG0137@2|Bacteria	2|Bacteria	E	argininosuccinate synthase activity	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
k59_174834_1	570417.WP1222	3.77e-162	454.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,47F63@766|Rickettsiales	766|Rickettsiales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
k59_174834_2	1236908.wNo_08730	5.8e-174	492.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,47F9I@766|Rickettsiales	766|Rickettsiales	EGP	Sugar (and other) transporter	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_204657_1	7425.NV17307-PA	3.79e-43	162.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BGB6@33208|Metazoa,3D5G4@33213|Bilateria,41ZUZ@6656|Arthropoda,3SKEY@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_25011_1	323848.Nmul_A0787	1.28e-118	351.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,372DI@32003|Nitrosomonadales	28216|Betaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_95732_1	7029.ACYPI35352-PA	4.22e-11	69.3	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXBC@33208|Metazoa,3DBAC@33213|Bilateria,421D4@6656|Arthropoda,3SR4B@50557|Insecta,3ED43@33342|Paraneoptera	33154|Opisthokonta	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_25020_1	570417.WP1157	3.95e-110	328.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,47ETU@766|Rickettsiales	766|Rickettsiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_114633_4	1123261.AXDW01000003_gene1978	1.06e-49	174.0	COG5526@1|root,COG5526@2|Bacteria,1RA0A@1224|Proteobacteria,1S4KY@1236|Gammaproteobacteria,1X9U5@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114633_6	670292.JH26_04685	2.51e-07	58.5	COG3637@1|root,COG3637@2|Bacteria,1NJWW@1224|Proteobacteria,2UD8G@28211|Alphaproteobacteria,1JV71@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Porin	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
k59_114633_9	644076.SCH4B_4353	2.26e-15	77.8	28ZCW@1|root,2ZM4M@2|Bacteria,1PA4U@1224|Proteobacteria,2UWUW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_114633_11	1127518.H9C0Y5_9CAUD	9.58e-69	235.0	4QAW1@10239|Viruses,4QWUW@35237|dsDNA viruses  no RNA stage,4QR8A@28883|Caudovirales,4QJW9@10662|Myoviridae	10662|Myoviridae	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_313739_1	1131266.ARWQ01000014_gene82	1.92e-93	278.0	COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota	651137|Thaumarchaeota	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
k59_194823_1	7029.ACYPI007813-PA	1.57e-35	144.0	2CMP4@1|root,2QR56@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_196263_1	1121861.KB899918_gene3222	2.64e-104	313.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2TV2Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
k59_216097_1	570417.WP0966	8.92e-310	860.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,47EYK@766|Rickettsiales	766|Rickettsiales	T	histidine kinase response regulator	dhkA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_295895_1	1304877.KI519399_gene4697	5.95e-40	143.0	COG0655@1|root,COG0655@2|Bacteria,1MX6A@1224|Proteobacteria,2TU75@28211|Alphaproteobacteria,3JTKI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
k59_196264_1	7159.AAEL017470-PA	5.51e-06	54.7	COG0515@1|root,KOG1152@2759|Eukaryota,38BA6@33154|Opisthokonta,3BC21@33208|Metazoa,3CVIZ@33213|Bilateria,41VZ3@6656|Arthropoda,3SKMJ@50557|Insecta,44ZXN@7147|Diptera,45CCP@7148|Nematocera	33208|Metazoa	T	Serine/Threonine protein kinases, catalytic domain	PASK	GO:0002791,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006417,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010646,GO:0010675,GO:0010677,GO:0010817,GO:0010906,GO:0010962,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019222,GO:0019538,GO:0023051,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032270,GO:0032501,GO:0032879,GO:0032881,GO:0032885,GO:0034248,GO:0034250,GO:0035091,GO:0036211,GO:0042592,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043255,GO:0043412,GO:0043467,GO:0043576,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045727,GO:0045912,GO:0046777,GO:0046883,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048871,GO:0050789,GO:0050794,GO:0051046,GO:0051049,GO:0051171,GO:0051173,GO:0051239,GO:0051246,GO:0051247,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070092,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090087,GO:0090276,GO:0097009,GO:0140096,GO:1901564,GO:1903530,GO:2000112,GO:2000113	2.7.11.1	ko:K08801	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PAS_9,Pkinase
k59_255854_1	7029.ACYPI006154-PA	3.49e-26	111.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_74814_1	570417.WP1052	1.11e-118	352.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,47F2S@766|Rickettsiales	766|Rickettsiales	M	Belongs to the peptidase S1C family	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_166982_1	7029.ACYPI20942-PA	7.12e-11	69.3	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB6K@33154|Opisthokonta,3BUWN@33208|Metazoa,3DBXU@33213|Bilateria,421HC@6656|Arthropoda	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_47121_1	570417.WP0902	1.68e-120	352.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,47F22@766|Rickettsiales	766|Rickettsiales	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
k59_137122_1	7070.TC002010-PA	2.81e-17	85.1	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_3
k59_186626_1	1101195.Meth11DRAFT_0142	1.81e-99	306.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKZR@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	General secretory system II protein E domain protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
k59_266319_1	1236908.wNo_08940	4.11e-73	222.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria,47FAI@766|Rickettsiales	766|Rickettsiales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
k59_186629_1	570417.WP0069	1.43e-113	333.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,47F15@766|Rickettsiales	766|Rickettsiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k59_234510_1	1459636.NTE_01908	6.83e-56	185.0	COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota	2157|Archaea	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
k59_314973_1	436308.Nmar_0003	2.38e-56	181.0	arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
k59_98645_1	742823.HMPREF9465_01678	8.04e-111	344.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,4PQDT@995019|Sutterellaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_138352_1	570417.WP0833	3.34e-127	374.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,47FF6@766|Rickettsiales	766|Rickettsiales	V	Ami_2	-	-	3.5.1.28	ko:K11066	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
k59_277201_1	748247.AZKH_1287	9.07e-41	156.0	COG0653@1|root,COG0653@2|Bacteria,1QZ1G@1224|Proteobacteria,2VQGH@28216|Betaproteobacteria,2KWYF@206389|Rhodocyclales	1224|Proteobacteria	U	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
k59_245331_1	7029.ACYPI37026-PA	2.34e-26	114.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	ko:K03102	ko04320,map04320	-	-	-	ko00000,ko00001,ko03019,ko03041	-	-	-	Exo_endo_phos_2,RVT_1
k59_88374_1	1459636.NTE_01640	6.65e-90	278.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
k59_98664_1	7029.ACYPI007212-PA	1.05e-35	139.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_235302_1	436308.Nmar_0102	1.28e-29	112.0	COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_235302_2	436308.Nmar_0101	2.12e-17	80.5	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_316054_1	436308.Nmar_0392	2.61e-20	91.3	COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k59_256935_1	7029.ACYPI073333-PA	1.75e-66	235.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_68401_1	570417.WP0084	1.08e-197	558.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,47EZT@766|Rickettsiales	766|Rickettsiales	M	Secretion protein	aprE	-	-	ko:K02022,ko:K12542	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	3.A.1.109.4,8.A.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
k59_57960_1	999141.GME_10066	9.67e-63	207.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1XIJV@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
k59_106132_1	891968.Anamo_0400	2.03e-51	177.0	COG1978@1|root,COG1978@2|Bacteria,3TA3Z@508458|Synergistetes	508458|Synergistetes	S	Selenoprotein B, glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
k59_48312_1	1454004.AW11_00092	4.64e-118	350.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1KQA3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
k59_98673_1	163164.WD_0997	1.14e-98	296.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,47EYU@766|Rickettsiales	766|Rickettsiales	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
k59_98673_2	1236908.wNo_07700	2.79e-130	379.0	COG0596@1|root,COG0596@2|Bacteria,1P0IP@1224|Proteobacteria	1224|Proteobacteria	S	Alpha beta hydrolase	sdbB	-	-	-	-	-	-	-	-	-	-	-	-
k59_206941_2	1110502.TMO_1916	1.4e-08	59.7	COG2165@1|root,COG2165@2|Bacteria,1Q5ZU@1224|Proteobacteria,2VC97@28211|Alphaproteobacteria,2JY6U@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_98690_1	436308.Nmar_1231	1.87e-65	217.0	COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k59_98690_2	436308.Nmar_1230	1.32e-22	88.6	arCOG08719@1|root,arCOG08719@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_106161_1	570417.WP0869	2.05e-103	306.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,47EVI@766|Rickettsiales	766|Rickettsiales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
k59_305376_1	570417.WP0795	1.45e-135	400.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,47F48@766|Rickettsiales	766|Rickettsiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
k59_127081_1	1236908.wNo_01730	1.99e-19	85.1	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2U5G4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ankyrin repeat	-	-	-	ko:K06867,ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_127081_2	570417.WP0506	3.36e-17	82.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2U5G4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ankyrin repeat	-	-	-	ko:K06867,ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_177323_2	570417.WP0006	1.03e-43	145.0	COG0781@1|root,COG0781@2|Bacteria,1PRNA@1224|Proteobacteria,2VAAJ@28211|Alphaproteobacteria,47FSA@766|Rickettsiales	766|Rickettsiales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_227191_1	1366050.N234_36085	8.69e-81	251.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32
k59_156500_1	7070.TC004197-PA	2.86e-39	143.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699,ko:K06515	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,ko05231,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204,map05231	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko04090	2.A.92.1.1	GT1	-	Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_17392_1	261292.Nit79A3_2789	1.88e-106	332.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM glycosyl transferase, family 51	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k59_235337_1	570417.WP0122	1.31e-146	421.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,47FBG@766|Rickettsiales	766|Rickettsiales	J	Ribonuclease D	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
k59_235337_2	570417.WP0121	2.09e-54	174.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,47FKR@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
k59_138429_1	163164.WD_1213	1.09e-42	151.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Astacin
k59_138429_2	1236908.wNo_05640	9.43e-46	152.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,47FII@766|Rickettsiales	766|Rickettsiales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
k59_156514_1	1430331.EP10_02850	4.69e-37	141.0	COG0477@1|root,COG0477@2|Bacteria,1TPHW@1239|Firmicutes,4H9YA@91061|Bacilli,1WEW9@129337|Geobacillus	91061|Bacilli	P	Fungal trichothecene efflux pump (TRI12)	yusP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_197488_1	1342299.Z947_120	6.79e-63	210.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
k59_58029_1	7029.ACYPI008531-PA	2.98e-52	190.0	COG2801@1|root,KOG3510@1|root,KOG0017@2759|Eukaryota,KOG3510@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,3EBZ8@33342|Paraneoptera	33208|Metazoa	L	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_168299_1	1229909.NSED_05505	3.3e-63	201.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
k59_88459_1	1163617.SCD_n02941	8.93e-20	88.2	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
k59_68460_1	395493.BegalDRAFT_0478	7.93e-31	117.0	COG4968@1|root,COG4968@2|Bacteria,1QUZW@1224|Proteobacteria,1T31D@1236|Gammaproteobacteria,463V3@72273|Thiotrichales	72273|Thiotrichales	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
k59_88465_1	1236908.wNo_09920	5.15e-15	70.9	COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,47FGM@766|Rickettsiales	766|Rickettsiales	S	Phage prohead protease	-	-	-	ko:K06904	-	-	-	-	ko00000	-	-	-	Peptidase_S78
k59_88465_2	1236908.wNo_09910	1.14e-60	195.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C,FKBP_N
k59_197511_1	388051.AUFE01000008_gene1699	3.55e-39	144.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
k59_17429_1	345073.VC395_1687	2.36e-73	234.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XUQZ@135623|Vibrionales	135623|Vibrionales	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
k59_38293_1	7897.ENSLACP00000019495	2.41e-16	90.9	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,48AQP@7711|Chordata,48YUZ@7742|Vertebrata	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_277299_1	7029.ACYPI062997-PA	5.82e-43	160.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3ATJT@33154|Opisthokonta,3C3T5@33208|Metazoa,3DJBA@33213|Bilateria	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_305405_1	7159.AAEL017299-PA	3.18e-93	305.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_286088_1	1187851.A33M_2910	2.28e-48	176.0	COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2TSSY@28211|Alphaproteobacteria,3FCG9@34008|Rhodovulum	28211|Alphaproteobacteria	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S78,Phage_capsid
k59_286088_2	1033991.RLEG12_18570	1.56e-31	123.0	COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,4B8W0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Phage head maturation protease	-	-	-	ko:K06904	-	-	-	-	ko00000	-	-	-	Peptidase_S78
k59_286088_3	388399.SSE37_25338	3.2e-30	128.0	COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2U4UA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phage portal protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_286088_4	460265.Mnod_4281	7.34e-244	691.0	COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,1JUJJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k59_27483_1	7029.ACYPI40233-PA	0.00014	49.7	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BXBC@33208|Metazoa,3DBAC@33213|Bilateria,421D4@6656|Arthropoda,3SR4B@50557|Insecta,3ED43@33342|Paraneoptera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_116960_1	1131266.ARWQ01000008_gene299	6.59e-35	125.0	arCOG00552@1|root,arCOG00552@2157|Archaea,41SRW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
k59_116960_2	1229909.NSED_01120	2.38e-17	81.6	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
k59_281192_1	1288494.EBAPG3_13660	1.14e-83	256.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,3727I@32003|Nitrosomonadales	28216|Betaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
k59_151511_3	857293.CAAU_1900	2.26e-07	53.9	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,36FVZ@31979|Clostridiaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
k59_22045_1	365044.Pnap_4081	5.15e-43	153.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJBE@28216|Betaproteobacteria,4AJ0F@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_281197_1	7425.NV22240-PA	4.71e-23	105.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_32178_1	1236908.wNo_00630	1.27e-221	615.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,47F3X@766|Rickettsiales	766|Rickettsiales	EGP	Major Facilitator Superfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
k59_32178_2	570417.WP0046	1.5e-35	124.0	COG1670@1|root,COG1670@2|Bacteria,1N5KX@1224|Proteobacteria,2UCAD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.82	ko:K00663	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_8
k59_181741_1	7029.ACYPI065684-PA	1.88e-18	90.5	KOG1075@1|root,KOG1893@1|root,KOG1075@2759|Eukaryota,KOG1893@2759|Eukaryota	2759|Eukaryota	S	mechanosensitive ion channel activity	-	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008381,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009987,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0022890,GO:0034220,GO:0042391,GO:0050896,GO:0050982,GO:0051179,GO:0051234,GO:0051606,GO:0051716,GO:0055085,GO:0065007,GO:0065008,GO:0071214,GO:0071260,GO:0071496,GO:0098655,GO:0104004	-	ko:K03102,ko:K22128	ko04320,map04320	-	-	-	ko00000,ko00001,ko02000,ko03019,ko03041,ko04131	1.A.75.1	-	-	Piezo_RRas_bdg,RVT_1,fn3
k59_1912_1	7237.FBpp0288310	2.95e-36	134.0	2D44E@1|root,2STUH@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_151528_1	13249.RPRC014533-PA	9.33e-28	112.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria,4224Q@6656|Arthropoda,3SR5P@50557|Insecta,3ED88@33342|Paraneoptera	33208|Metazoa	L	retrotransposable element Tf2 155 kDa protein type 1-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_71472_1	263358.VAB18032_18200	0.000163	47.4	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	5.4.3.8	ko:K01845,ko:K07100	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Amidohydro_2,Aminotran_3
k59_61967_1	1229909.NSED_07770	7.42e-103	307.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
k59_291444_1	7668.SPU_001414-tr	1.31e-52	190.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria	33208|Metazoa	E	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2
k59_151535_1	7213.XP_004520233.1	6.22e-48	174.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_61972_1	1238450.VIBNISOn1_300028	5.56e-111	327.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XU72@135623|Vibrionales	135623|Vibrionales	S	transport system periplasmic component	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
k59_231123_1	1236908.wNo_01250	5.84e-153	444.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Metallophos
k59_171876_1	1236908.wNo_04240	6.69e-142	437.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47GS5@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeats (many copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Peptidase_M9
k59_261577_1	7029.ACYPI42956-PA	7.39e-14	81.3	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3C5WU@33208|Metazoa,3DG3H@33213|Bilateria,422D9@6656|Arthropoda,3SR1F@50557|Insecta	33154|Opisthokonta	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_221484_1	1236908.wNo_02580	1.77e-119	380.0	COG0085@1|root,COG0086@1|root,COG0085@2|Bacteria,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,47ETY@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_52048_2	1229909.NSED_06335	4.72e-138	401.0	COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota	651137|Thaumarchaeota	D	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,MIT,Vps4_C
k59_22082_2	1220717.L7TNH6_9VIRU	4.08e-09	65.5	4QAKZ@10239|Viruses	10239|Viruses	S	N-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_211568_2	1121904.ARBP01000014_gene81	7.53e-05	44.7	COG4977@1|root,COG4977@2|Bacteria,4PNQU@976|Bacteroidetes	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
k59_42277_2	436308.Nmar_0111	9.51e-79	236.0	COG0432@1|root,arCOG04214@2157|Archaea,41T31@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
k59_191788_1	7159.AAEL017989-PA	1.17e-50	183.0	2F5TP@1|root,2T6V3@2759|Eukaryota,390YU@33154|Opisthokonta,3C6QH@33208|Metazoa,3DMPP@33213|Bilateria,42480@6656|Arthropoda,3STE5@50557|Insecta,457SD@7147|Diptera,45M2J@7148|Nematocera	7159.AAEL017989-PA|-	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_211587_1	395493.BegalDRAFT_0212	1.1e-108	326.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k59_82248_1	7176.CPIJ013333-PA	7.82e-16	79.3	KOG0494@1|root,KOG0494@2759|Eukaryota,3APVI@33154|Opisthokonta,3C1Z9@33208|Metazoa,3DIDN@33213|Bilateria,422YG@6656|Arthropoda,3SZ7U@50557|Insecta,458PX@7147|Diptera,45J6X@7148|Nematocera	33208|Metazoa	K	Homeodomain	-	-	-	-	-	-	-	-	-	-	-	-	Homeobox
k59_101588_1	330214.NIDE2440	3.47e-71	241.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,3J0HX@40117|Nitrospirae	40117|Nitrospirae	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
k59_271588_1	7176.CPIJ018926-PA	1.18e-40	145.0	2D5IC@1|root,2SYNT@2759|Eukaryota,3AUJS@33154|Opisthokonta,3C93N@33208|Metazoa,3DJQ2@33213|Bilateria	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_311107_1	1236908.wNo_03430	2.63e-150	446.0	COG3164@1|root,COG3164@2|Bacteria,1QW23@1224|Proteobacteria,2TWM9@28211|Alphaproteobacteria,47GT3@766|Rickettsiales	766|Rickettsiales	S	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
k59_251512_1	70448.A0A096P8Y7	1e-21	92.8	COG0137@1|root,KOG1706@2759|Eukaryota,37QUX@33090|Viridiplantae,34H88@3041|Chlorophyta	3041|Chlorophyta	E	argininosuccinate synthase	-	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_251512_2	522306.CAP2UW1_3084	1.41e-89	271.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,1KQFK@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_141849_1	880073.Calab_0632	5.9e-09	57.8	COG0549@1|root,COG0549@2|Bacteria,2NNKM@2323|unclassified Bacteria	2|Bacteria	E	Amino acid kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452	AA_kinase
k59_141849_2	1110502.TMO_1195	1.35e-16	80.5	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2TSZU@28211|Alphaproteobacteria,2JR1R@204441|Rhodospirillales	204441|Rhodospirillales	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
k59_32271_1	7070.TC016101-PA	5.52e-41	154.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQX5@50557|Insecta	33208|Metazoa	C	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.2.29	ko:K15407	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_101601_1	272560.BPSL2271	2.78e-94	282.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1JZYF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k59_171928_1	7070.TC016129-PA	1.82e-93	326.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_82270_1	1236908.wNo_08080	9.27e-77	244.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,47EWS@766|Rickettsiales	766|Rickettsiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_82270_2	1236908.wNo_08070	1.18e-80	240.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,47FMU@766|Rickettsiales	766|Rickettsiales	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
k59_71526_1	7029.ACYPI23453-PA	8.52e-33	140.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_62006_2	7070.TC016129-PA	4.01e-143	475.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_191827_1	1459636.NTE_02642	8.85e-52	174.0	COG2047@1|root,arCOG00348@2157|Archaea	2157|Archaea	S	protein (ATP-grasp superfamily)	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
k59_311118_1	570417.WP0648	8.42e-32	120.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,Pkinase,Sel1,U-box
k59_311118_2	1236908.wNo_03450	2.93e-90	280.0	COG0666@1|root,COG0666@2|Bacteria,1N0BQ@1224|Proteobacteria	1224|Proteobacteria	O	ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_311118_3	570417.WP0649	3.97e-108	320.0	COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,47EUP@766|Rickettsiales	766|Rickettsiales	S	Phage portal protein, HK97 family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
k59_191828_1	1209072.ALBT01000028_gene1290	1e-67	215.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides	gtrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
k59_251536_1	69319.XP_008553167.1	1.07e-29	124.0	2CWTA@1|root,2RV75@2759|Eukaryota,38WQJ@33154|Opisthokonta,3C6CU@33208|Metazoa,3DME6@33213|Bilateria,42CM4@6656|Arthropoda,3SY8M@50557|Insecta,46MJ3@7399|Hymenoptera	69319.XP_008553167.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_241054_1	1229909.NSED_09635	6.26e-55	174.0	arCOG04038@1|root,arCOG04038@2157|Archaea,41SQU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_241054_2	436308.Nmar_1798	1.05e-15	70.1	arCOG00818@1|root,arCOG00818@2157|Archaea	2157|Archaea	S	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
k59_102744_1	387631.Asulf_01944	6.57e-43	159.0	COG4666@1|root,arCOG01906@2157|Archaea,2XTB3@28890|Euryarchaeota	28890|Euryarchaeota	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_53563_1	31234.CRE17270	3.56e-54	192.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,40FA2@6231|Nematoda,1KXU9@119089|Chromadorea,411FR@6236|Rhabditida	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,gag-asp_proteas,rve,zf-CCHC
k59_72649_2	570417.WP0170	3.31e-237	653.0	COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria,47FJ4@766|Rickettsiales	766|Rickettsiales	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
k59_72649_3	570417.WP0166	7.08e-15	73.2	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,47F2V@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
k59_102749_1	398767.Glov_2205	8.17e-50	176.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,43UXK@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
k59_293018_1	7159.AAEL005015-PA	1.73e-87	285.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VPS@33154|Opisthokonta,3C5ZM@33208|Metazoa,3DM1B@33213|Bilateria,42CJJ@6656|Arthropoda,3STFX@50557|Insecta,4582J@7147|Diptera,45M6U@7148|Nematocera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_133865_1	436308.Nmar_0819	4.59e-95	288.0	COG0156@1|root,arCOG00113@2157|Archaea,41SAP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	8-amino-7-oxononanoate synthase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_222914_1	640081.Dsui_2814	3.35e-99	310.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_163759_1	713586.KB900536_gene1143	7.83e-08	53.1	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1WXQ1@135613|Chromatiales	135613|Chromatiales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
k59_222917_1	570417.WP0771	7.08e-192	538.0	COG4928@1|root,COG4928@2|Bacteria,1Q4X0@1224|Proteobacteria,2TTPM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
k59_293034_1	78245.Xaut_3679	1.88e-31	115.0	2DKVY@1|root,30IDW@2|Bacteria,1RE6Y@1224|Proteobacteria,2U8WV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	YqaJ-like viral recombinase domain	-	-	-	-	-	-	-	-	-	-	-	-	YqaJ
k59_253038_1	7029.ACYPI56814-PA	3.22e-11	68.9	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3DE2J@33213|Bilateria	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_61773_2	8479.XP_008175316.1	1.09e-85	305.0	COG2373@1|root,COG2801@1|root,KOG0017@2759|Eukaryota,KOG1366@2759|Eukaryota,38DGN@33154|Opisthokonta,3BCF2@33208|Metazoa,3CTZZ@33213|Bilateria,480CR@7711|Chordata	33208|Metazoa	O	serine-type endopeptidase inhibitor activity	A2ML1	-	-	ko:K03910	ko04610,map04610	-	-	-	ko00000,ko00001,ko04131,ko04147	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
k59_92009_1	1511.CLOST_0981	1.69e-41	153.0	COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,25SUQ@186804|Peptostreptococcaceae	186801|Clostridia	H	CobB/CobQ-like glutamine amidotransferase domain	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
k59_101407_1	570417.WP0913	1.52e-295	833.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,47FZJ@766|Rickettsiales	766|Rickettsiales	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_221284_1	570417.WP1075	8.63e-75	230.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,47F6G@766|Rickettsiales	766|Rickettsiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k59_221284_2	570417.WP1076	3.86e-103	310.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,47FYZ@766|Rickettsiales	766|Rickettsiales	S	PmbA protein	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k59_82022_1	7029.ACYPI52857-PA	4.62e-109	379.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_191570_1	570417.WP0606	2.99e-06	53.5	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4
k59_201529_1	7176.CPIJ017399-PA	1.14e-10	65.1	KOG3656@1|root,KOG3656@2759|Eukaryota,394XK@33154|Opisthokonta,3C9TX@33208|Metazoa,3DQYE@33213|Bilateria,42746@6656|Arthropoda,3SWXN@50557|Insecta,457GV@7147|Diptera,45MFP@7148|Nematocera	33208|Metazoa	S	G-protein coupled receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_42060_1	570417.WP0906	1.18e-55	189.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,47F86@766|Rickettsiales	766|Rickettsiales	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
k59_42060_2	570417.WP0907	4.93e-56	189.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF4154,HATPase_c,HisKA,Prophage_tail,SNase
k59_171680_1	891968.Anamo_1991	0.000144	49.3	COG1840@1|root,COG1840@2|Bacteria,3TBZA@508458|Synergistetes	508458|Synergistetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
k59_71321_1	1163617.SCD_n02946	2.51e-07	52.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
k59_71321_2	522306.CAP2UW1_4183	3.11e-67	214.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,1KPPD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
k59_82028_1	7159.AAEL018016-PA	1.87e-32	120.0	KOG4012@1|root,KOG4012@2759|Eukaryota,3A73W@33154|Opisthokonta,3BSV0@33208|Metazoa,3D97P@33213|Bilateria,420FB@6656|Arthropoda,3SNP5@50557|Insecta,454U2@7147|Diptera,45MQ0@7148|Nematocera	33208|Metazoa	B	Domain in histone families 1 and 5	HIST1H1A	GO:0000003,GO:0000228,GO:0000785,GO:0000790,GO:0000791,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005539,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005719,GO:0006325,GO:0006342,GO:0006355,GO:0006996,GO:0007276,GO:0007283,GO:0008150,GO:0008201,GO:0009889,GO:0009890,GO:0009892,GO:0009986,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010639,GO:0016043,GO:0016458,GO:0019219,GO:0019222,GO:0019953,GO:0022414,GO:0030100,GO:0031056,GO:0031057,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031399,GO:0031400,GO:0031490,GO:0031974,GO:0031981,GO:0031982,GO:0032268,GO:0032269,GO:0032501,GO:0032504,GO:0032879,GO:0033043,GO:0033044,GO:0040029,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044703,GO:0045807,GO:0045814,GO:0045892,GO:0045934,GO:0048232,GO:0048259,GO:0048260,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048609,GO:0050789,GO:0050794,GO:0051049,GO:0051050,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051276,GO:0051704,GO:0060255,GO:0060627,GO:0065007,GO:0070013,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:1901363,GO:1901681,GO:1902275,GO:1902679,GO:1903506,GO:1903507,GO:1905268,GO:2000112,GO:2000113,GO:2001141,GO:2001251	-	ko:K11253,ko:K11275	ko05034,ko05202,ko05322,map05034,map05202,map05322	-	-	-	ko00000,ko00001,ko03036,ko04147	-	-	-	Linker_histone
k59_111746_1	1294143.H681_04940	7.3e-32	116.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA	-	-	ko:K02650,ko:K02655	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
k59_181593_2	1126627.BAWE01000004_gene4265	4.39e-49	172.0	COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2TSGI@28211|Alphaproteobacteria,3JQXT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	OU	Phage portal protein, lambda family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal_2
k59_1776_2	1236908.wNo_07580	5.28e-60	204.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1QVTW@1224|Proteobacteria,2TWJK@28211|Alphaproteobacteria,47EUW@766|Rickettsiales	766|Rickettsiales	CEH	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	gltD	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
k59_32077_1	261292.Nit79A3_1705	2.49e-09	58.2	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2VQNZ@28216|Betaproteobacteria,372YC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome c, class I	cyc	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
k59_291309_1	977880.RALTA_A2741	2.85e-45	159.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6T9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_231025_1	436308.Nmar_0718	7.51e-05	44.7	COG1173@1|root,arCOG00749@2157|Archaea,41SFE@651137|Thaumarchaeota	651137|Thaumarchaeota	P	inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_231025_2	436308.Nmar_0719	5.93e-121	353.0	COG0601@1|root,arCOG00751@2157|Archaea,41S7B@651137|Thaumarchaeota	651137|Thaumarchaeota	P	inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_61833_1	5297.GMQ_25919T0	1.28e-37	152.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3UY7N@5204|Basidiomycota,2YC45@29000|Pucciniomycotina	4751|Fungi	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,rve
k59_211433_1	330214.NIDE1425	2.05e-117	352.0	COG0173@1|root,COG0173@2|Bacteria,3J0FR@40117|Nitrospirae	40117|Nitrospirae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k59_151429_1	570417.WP0822	8.57e-129	368.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,47F70@766|Rickettsiales	766|Rickettsiales	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
k59_161916_1	1229909.NSED_02285	5.57e-117	340.0	COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
k59_161916_2	436308.Nmar_0442	4.12e-17	75.1	arCOG08760@1|root,arCOG08760@2157|Archaea,41T7P@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_92096_1	7070.TC015470-PA	1.88e-64	224.0	COG2801@1|root,KOG1922@1|root,KOG0017@2759|Eukaryota,KOG1922@2759|Eukaryota,38C7D@33154|Opisthokonta,3BDNK@33208|Metazoa,3CX9J@33213|Bilateria,41VES@6656|Arthropoda,3SHX8@50557|Insecta	33208|Metazoa	TZ	Actin binding. It is involved in the biological process described with cellular component organization	FHDC1	GO:0001763,GO:0002009,GO:0002064,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005884,GO:0007275,GO:0007424,GO:0008092,GO:0008150,GO:0009653,GO:0009888,GO:0009987,GO:0015629,GO:0030154,GO:0030855,GO:0031110,GO:0031113,GO:0031941,GO:0032092,GO:0032271,GO:0032501,GO:0032502,GO:0032886,GO:0032991,GO:0033043,GO:0035146,GO:0035147,GO:0035150,GO:0035239,GO:0035295,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043393,GO:0044087,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0048468,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051128,GO:0051493,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061138,GO:0065007,GO:0065008,GO:0065009,GO:0070507,GO:0090066,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:1902903,GO:1904529,GO:1904531,GO:1904616,GO:1904618	-	-	-	-	-	-	-	-	-	-	Drf_FH3,FH2
k59_310961_1	1229909.NSED_04515	1.39e-77	238.0	COG5491@1|root,arCOG00452@2157|Archaea,41T30@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251324_1	1236908.wNo_06530	8.98e-228	629.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,47EYG@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k59_101457_1	1430440.MGMSRv2_1304	2.06e-58	190.0	COG0535@1|root,COG0535@2|Bacteria,1N5G8@1224|Proteobacteria,2VB0H@28211|Alphaproteobacteria,2JVSF@204441|Rhodospirillales	204441|Rhodospirillales	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
k59_261444_1	67593.Physo132874	2.1e-59	209.0	COG2801@1|root,KOG0017@2759|Eukaryota,3QH4V@4776|Peronosporales	4776|Peronosporales	L	GAG-pre-integrase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_32106_1	330214.NIDE4318	2.06e-61	212.0	COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae	40117|Nitrospirae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k59_181651_1	1188252.AJYK01000005_gene2951	1.68e-27	114.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1XTHQ@135623|Vibrionales	135623|Vibrionales	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
k59_240915_2	251221.35212193	8.21e-62	192.0	COG3293@1|root,COG3293@2|Bacteria,1G7GI@1117|Cyanobacteria	1117|Cyanobacteria	L	similarity to GB CAD86359.1	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_42149_1	330214.NIDE2735	2.77e-88	272.0	COG1109@1|root,COG1109@2|Bacteria,3J0E7@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_201615_1	1125973.JNLC01000018_gene2320	4.25e-70	227.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
k59_32120_1	1429916.X566_01060	3.46e-169	484.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,3JU3U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_29490	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_271460_1	1236908.wNo_02090	1.55e-111	326.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,47GQI@766|Rickettsiales	766|Rickettsiales	GM	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	-
k59_271460_2	1236908.wNo_02080	1.73e-37	139.0	COG0438@1|root,COG0535@1|root,COG0438@2|Bacteria,COG0535@2|Bacteria,1NB81@1224|Proteobacteria,2U3FD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	wgeD	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Radical_SAM,SPASM
k59_211475_1	570417.WP0642	7.78e-131	388.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,47EUI@766|Rickettsiales	766|Rickettsiales	E	COG0006 Xaa-Pro aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
k59_162967_1	7425.NV20113-PA	5.92e-24	103.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	1.1.1.206	ko:K08081,ko:K21596	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R02832	RC00144	ko00000,ko00001,ko01000,ko03000	-	-	-	Exo_endo_phos_2,RVT_1,RVT_3
k59_222320_1	1101192.KB910516_gene2310	3.68e-62	201.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TTXX@28211|Alphaproteobacteria,1JRZX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	ET	PFAM extracellular solute-binding protein family 3	gltI	-	-	ko:K02030,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_93181_1	7425.NV21123-PA	8.97e-36	144.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria,42261@6656|Arthropoda,3SQT9@50557|Insecta	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_12863_1	570417.WP0787	1.6e-105	330.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Cu_amine_oxidN1
k59_212461_1	357808.RoseRS_1007	7.02e-18	88.2	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,376IG@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.1.3.1,6.2.1.3	ko:K01897,ko:K22319	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
k59_52846_1	10224.XP_006816326.1	6.64e-12	70.9	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A17,rve
k59_142645_1	570417.WP0554	3.02e-128	405.0	COG0085@1|root,COG0086@1|root,COG0085@2|Bacteria,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,47ETY@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_262415_1	570417.WP0625	4.24e-188	543.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,47F2J@766|Rickettsiales	766|Rickettsiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
k59_272440_1	5061.CADANGAP00007306	0.000121	50.1	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3P0R9@4751|Fungi,3QZKV@4890|Ascomycota,20J9K@147545|Eurotiomycetes,3S9VD@5042|Eurotiales	4751|Fungi	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_152317_1	1123393.KB891330_gene774	1.35e-64	208.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1KSCN@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome C oxidase subunit II, transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	COX2,COX2_TM,Cytochrome_CBB3
k59_33185_1	1131266.ARWQ01000004_gene1450	2.17e-79	246.0	COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
k59_33185_2	1229909.NSED_07145	2.91e-33	114.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41SVX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
k59_192646_1	436308.Nmar_0347	4.77e-169	503.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_133060_2	762983.HMPREF9444_01369	2.83e-27	101.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1Y4TI@135624|Aeromonadales	135624|Aeromonadales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k59_133060_3	795666.MW7_2305	5.87e-06	47.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VJ9X@28216|Betaproteobacteria,1K1D2@119060|Burkholderiaceae	28216|Betaproteobacteria	CE	Tartrate dehydrogenase	ttuC	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
k59_212488_1	7029.ACYPI081537-PA	1.6e-36	143.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,42AN1@6656|Arthropoda	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_231782_2	570417.WP0071	7.72e-150	426.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,47F3S@766|Rickettsiales	766|Rickettsiales	G	fructose-1,6-bisphosphatase	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
k59_62847_1	570417.WP1102	3.66e-150	433.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,47F34@766|Rickettsiales	766|Rickettsiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k59_62847_2	570417.WP1103	1.9e-61	207.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,47EU2@766|Rickettsiales	766|Rickettsiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k59_33213_1	1100720.ALKN01000024_gene1553	1.1e-129	379.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae	28216|Betaproteobacteria	E	amino acid	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
k59_222363_1	436308.Nmar_0821	2.1e-99	297.0	COG0502@1|root,arCOG00658@2157|Archaea,41S9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
k59_2748_1	7425.NV23196-PA	1.58e-37	150.0	KOG1075@1|root,KOG1075@2759|Eukaryota,38Y73@33154|Opisthokonta,3C62S@33208|Metazoa,3DM4M@33213|Bilateria,42C97@6656|Arthropoda,3SU11@50557|Insecta,46MRF@7399|Hymenoptera	2759|Eukaryota	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_272477_1	1434929.X946_4825	3.19e-21	88.6	COG0071@1|root,COG0071@2|Bacteria,1N1RF@1224|Proteobacteria,2VT18@28216|Betaproteobacteria,1K7M3@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
k59_272477_2	626887.J057_19930	1.78e-14	67.8	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,1SGQG@1236|Gammaproteobacteria,46912@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	protein, possibly involved in nitrogen fixation	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
k59_33222_1	1229909.NSED_09305	1.15e-107	321.0	COG0399@1|root,arCOG00118@2157|Archaea,41S96@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_33222_2	1229909.NSED_09310	2.5e-93	276.0	arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_97463_1	1236908.wNo_00730	7.21e-111	340.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K18376	-	M00660	-	-	ko00000,ko00002,ko02044	1.C.65.1	-	-	DUF1542,Mob_Pre,Relaxase,YSIRK_signal
k59_67358_1	7070.TC001491-PA	2.07e-56	198.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_255927_1	106582.XP_004571522.1	2.98e-09	63.2	COG1524@1|root,KOG1075@1|root,KOG1075@2759|Eukaryota,KOG2645@2759|Eukaryota	2759|Eukaryota	BK	nucleotide diphosphatase activity	ENPP7	GO:0003674,GO:0003824,GO:0004620,GO:0004767,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005902,GO:0006275,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006665,GO:0006684,GO:0006687,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0008156,GO:0008270,GO:0008285,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0012505,GO:0016020,GO:0016021,GO:0016298,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019637,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0042127,GO:0042578,GO:0042995,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097164,GO:0098858,GO:0120025,GO:1901135,GO:1901564,GO:1903509,GO:2000112,GO:2000113	1.14.14.1,2.6.1.1,3.1.3.16,3.1.4.12	ko:K06115,ko:K07408,ko:K12354,ko:K14454,ko:K14803	ko00140,ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00380,ko00400,ko00600,ko00710,ko00830,ko00950,ko00960,ko00980,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04913,ko05204,map00140,map00220,map00250,map00270,map00330,map00350,map00360,map00380,map00400,map00600,map00710,map00830,map00950,map00960,map00980,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04913,map05204	M00170,M00171	R00355,R00694,R00734,R00896,R02354,R02355,R02433,R02541,R02619,R03089,R03408,R03629,R05052,R07000,R07001,R07021,R07022,R07079,R07080,R07081,R07085,R07087,R07098,R07099,R08390,R08392,R09418,R09423,R09442	RC00006,RC00017,RC00046,RC00425,RC00661,RC00704,RC00723,RC00724,RC01444,RC01445,RC01727,RC01732,RC01733,RC02531	ko00000,ko00001,ko00002,ko00199,ko01000,ko01007,ko01009,ko03009,ko04131,ko04147,ko04812	-	-	-	Phosphodiest,RVT_1
k59_186689_1	1229909.NSED_09675	4.89e-107	321.0	COG1252@1|root,arCOG01067@2157|Archaea	2157|Archaea	C	COG1252 NADH dehydrogenase, FAD-containing subunit	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k59_105305_1	306281.AJLK01000201_gene544	1.11e-31	120.0	COG2230@1|root,COG2230@2|Bacteria,1G3TN@1117|Cyanobacteria,1JK00@1189|Stigonemataceae	1117|Cyanobacteria	M	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
k59_255937_1	1236908.wNo_04400	7.51e-220	611.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,47EY2@766|Rickettsiales	766|Rickettsiales	H	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_74885_1	1236908.wNo_04560	1.3e-173	493.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,47FA1@766|Rickettsiales	766|Rickettsiales	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
k59_234577_1	1459636.NTE_01099	5.67e-92	276.0	COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
k59_6019_1	1131266.ARWQ01000001_gene1123	7.64e-95	291.0	COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Phenylalanyl-tRNA synthetase alpha subunit	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
k59_176260_1	330214.NIDE2073	8.3e-91	285.0	COG1389@1|root,COG1389@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
k59_216220_1	319003.Bra1253DRAFT_00024	6.27e-18	84.3	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JX5H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
k59_216220_2	580332.Slit_2787	2.28e-37	128.0	COG2963@1|root,COG2963@2|Bacteria,1N3E0@1224|Proteobacteria,2VYHT@28216|Betaproteobacteria,44WKH@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
k59_206028_1	7425.NV18932-PA	4.21e-35	139.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta,46N15@7399|Hymenoptera	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_37142_1	1236908.wNo_09140	9.72e-74	248.0	COG1672@1|root,COG5539@1|root,COG1672@2|Bacteria,COG5539@2|Bacteria	2|Bacteria	O	protein K27-linked deubiquitination	-	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0036210,GO:0036211,GO:0043087,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044033,GO:0044238,GO:0046872,GO:0050568,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009,GO:0071704,GO:0140096,GO:1901564	-	ko:K06921,ko:K15354	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	AAA_16,KAP_NTPase,Mrr_cat,NACHT,SIR2_2,Tox-PLDMTX
k59_285238_1	706587.Desti_1075	4.64e-64	220.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_56928_1	887062.HGR_08149	2.19e-22	97.1	COG3181@1|root,COG3181@2|Bacteria,1N4MC@1224|Proteobacteria,2VKJS@28216|Betaproteobacteria,4ABJ4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_285241_1	1122185.N792_12705	4.24e-70	219.0	COG0705@1|root,COG0705@2|Bacteria,1RD88@1224|Proteobacteria,1S5NF@1236|Gammaproteobacteria,1X4YW@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
k59_196415_1	203122.Sde_0034	0.00017	52.4	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,1RBY7@1224|Proteobacteria,1SYWB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Chondroitinase B	-	-	-	-	-	-	-	-	-	-	-	-	Chondroitinas_B,F5_F8_type_C
k59_226077_2	121225.PHUM531970-PA	1.73e-175	545.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_266448_1	1236908.wNo_05280	1.08e-115	338.0	2DV9H@1|root,33UVC@2|Bacteria,1NV8W@1224|Proteobacteria,2URNP@28211|Alphaproteobacteria,47G6U@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_255983_2	234267.Acid_6862	6.16e-36	129.0	COG2801@1|root,COG2801@2|Bacteria,3Y6NP@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
k59_37166_1	7176.CPIJ001819-PA	2.46e-31	125.0	2E0WI@1|root,2S89W@2759|Eukaryota,397E2@33154|Opisthokonta,3CBQ5@33208|Metazoa,3DSZQ@33213|Bilateria,424KF@6656|Arthropoda,3STV6@50557|Insecta,45B4K@7147|Diptera,45KZ8@7148|Nematocera	33208|Metazoa	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_56943_1	7029.ACYPI52857-PA	4.41e-66	234.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_155572_3	1380390.JIAT01000009_gene646	3.02e-06	57.8	COG5295@1|root,COG5295@2|Bacteria,2GUMK@201174|Actinobacteria	201174|Actinobacteria	UW	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
k59_155572_5	1121422.AUMW01000021_gene1621	3.82e-12	68.6	COG3108@1|root,COG3409@1|root,COG3108@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.4.17.14	ko:K08640	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	PG_binding_1,Peptidase_M15_3,Transglycosylas
k59_97561_3	56780.SYN_01900	3.41e-08	59.3	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42T20@68525|delta/epsilon subdivisions,2WP7S@28221|Deltaproteobacteria,2MQGC@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM Integrase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_26470_1	523791.Kkor_1664	3.01e-21	95.5	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XHN6@135619|Oceanospirillales	135619|Oceanospirillales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_26470_2	330214.NIDE1078	8.34e-08	52.8	COG0597@1|root,COG0597@2|Bacteria,3J0S2@40117|Nitrospirae	40117|Nitrospirae	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
k59_146232_1	436308.Nmar_1085	2.83e-126	391.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_226095_1	570417.WP0175	1.26e-280	795.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,47ETW@766|Rickettsiales	766|Rickettsiales	L	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	recB	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
k59_276290_1	7029.ACYPI21006-PA	5.42e-41	158.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria,42261@6656|Arthropoda	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10577	ko03013,ko04064,ko04120,ko05206,map03013,map04064,map04120,map05206	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko04121	-	-	-	RVT_1
k59_216263_1	436308.Nmar_0620	1.18e-133	399.0	COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
k59_137320_1	436308.Nmar_0348	1.36e-102	328.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_176316_1	7425.NV30710-PA	1.93e-30	126.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_167202_1	1485544.JQKP01000002_gene1376	1.09e-76	258.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,44V4V@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
k59_226109_1	570417.WP1271	3.54e-66	218.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2U258@28211|Alphaproteobacteria,47F16@766|Rickettsiales	766|Rickettsiales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
k59_268025_1	120017.I2FSY3	5.07e-09	63.2	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3UY7N@5204|Basidiomycota	4751|Fungi	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve
k59_235564_1	1333856.L686_10925	8.07e-10	55.8	COG1742@1|root,COG1742@2|Bacteria,1MZI8@1224|Proteobacteria,1SA4U@1236|Gammaproteobacteria,1Z2Z1@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	UPF0060 membrane protein	-	-	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
k59_235564_2	1094715.CM001373_gene2222	8.63e-45	149.0	COG0599@1|root,COG0599@2|Bacteria,1P0E1@1224|Proteobacteria	1224|Proteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
k59_75931_1	7070.TC004227-PA	1.19e-109	361.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_58292_1	1236908.wNo_03820	4.97e-23	95.5	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,47G30@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_58292_2	1236908.wNo_03830	5.87e-156	442.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,47EUG@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k59_177638_1	1121035.AUCH01000021_gene2706	5.93e-48	160.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,2KW8U@206389|Rhodocyclales	206389|Rhodocyclales	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
k59_68715_1	69319.XP_008558577.1	6.94e-26	110.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_38535_1	1236908.wNo_00210	1.67e-148	421.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,47F9P@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
k59_106470_1	234267.Acid_2554	1.92e-88	274.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_75942_1	247490.KSU1_B0100	2.37e-181	515.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_197814_1	330214.NIDE3081	1.21e-126	363.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
k59_168663_1	570417.WP0079	6.89e-62	210.0	COG3164@1|root,COG3164@2|Bacteria,1MVDY@1224|Proteobacteria,2TSGG@28211|Alphaproteobacteria,47F6Q@766|Rickettsiales	766|Rickettsiales	S	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
k59_168663_2	1236908.wNo_00440	2.35e-84	250.0	COG1238@1|root,COG1238@2|Bacteria	2|Bacteria	I	metal cluster binding	yqaA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
k59_168663_3	570417.WP0077	5.1e-60	197.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,47ETK@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
k59_245688_2	330214.NIDE2641	6.95e-43	140.0	COG1278@1|root,COG1278@2|Bacteria,3J0QZ@40117|Nitrospirae	40117|Nitrospirae	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_245688_3	330214.NIDE2642	5.7e-41	145.0	COG0795@1|root,COG0795@2|Bacteria,3J0S0@40117|Nitrospirae	40117|Nitrospirae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
k59_88800_1	713587.THITH_03235	1.54e-62	213.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k59_316445_1	6334.EFV53978	1.33e-09	69.3	2D40F@1|root,2STF3@2759|Eukaryota,38YST@33154|Opisthokonta,3C23D@33208|Metazoa	6334.EFV53978|-	S	Protein of unknown function (DUF1759)	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_227553_1	27923.ML13569a-PA	2.23e-41	165.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta	33154|Opisthokonta	L	MAP kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_88801_1	7176.CPIJ019125-PA	7.68e-19	94.4	COG1131@1|root,KOG0061@2759|Eukaryota,38CVQ@33154|Opisthokonta,3BMMP@33208|Metazoa,3D2T5@33213|Bilateria,41X63@6656|Arthropoda,3SIBB@50557|Insecta,4510V@7147|Diptera,45H0R@7148|Nematocera	33208|Metazoa	Q	ABC-2 type transporter	-	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015248,GO:0015318,GO:0015399,GO:0015405,GO:0015850,GO:0015918,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017127,GO:0022804,GO:0022857,GO:0030301,GO:0031224,GO:0033036,GO:0034040,GO:0034041,GO:0042623,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1901618	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran
k59_99143_1	27923.ML35603a-PA	1.91e-23	110.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1,RVT_3
k59_277628_1	436308.Nmar_0011	3.67e-243	685.0	COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
k59_268110_1	1162668.LFE_2212	1.27e-104	314.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
k59_17745_1	331113.SNE_A16690	8.78e-120	355.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
k59_156822_1	330214.NIDE0243	2.1e-57	186.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4,Sterile
k59_38581_1	76114.ebA872	7.49e-56	181.0	COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,2VRHA@28216|Betaproteobacteria,2KYN1@206389|Rhodocyclales	206389|Rhodocyclales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k59_75985_1	1392488.JHZY01000004_gene2361	6.07e-14	78.2	COG3002@1|root,COG3002@2|Bacteria,4NECE@976|Bacteroidetes,1I0SZ@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k59_185715_1	1236908.wNo_06780	4.52e-14	66.2	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,47FS8@766|Rickettsiales	766|Rickettsiales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
k59_185715_2	570417.WP0981	4.86e-154	434.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,47FBV@766|Rickettsiales	766|Rickettsiales	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
k59_255140_1	1229909.NSED_01320	6.82e-159	458.0	COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_154817_1	59196.RICGR_0197	7.05e-49	182.0	COG0666@1|root,COG1672@1|root,COG0666@2|Bacteria,COG1672@2|Bacteria,1QVBB@1224|Proteobacteria,1T2B2@1236|Gammaproteobacteria,1JGFI@118969|Legionellales	2|Bacteria	S	Annotation was generated automatically without manual curation	anK3	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,SUFU
k59_86248_1	1561998.Csp11.Scaffold629.g15268.t2	1.14e-124	432.0	KOG4740@1|root,KOG4740@2759|Eukaryota,3A14S@33154|Opisthokonta,3BPYG@33208|Metazoa,3D6ZJ@33213|Bilateria,40RH8@6231|Nematoda,1M8MG@119089|Chromadorea,40VFN@6236|Rhabditida	33208|Metazoa	S	proton channel activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,RVT_1,Retrotrans_gag,rve
k59_136208_1	3750.XP_008337255.1	4.15e-75	270.0	COG2801@1|root,KOG4197@1|root,KOG0017@2759|Eukaryota,KOG4197@2759|Eukaryota,37THH@33090|Viridiplantae,3GG2K@35493|Streptophyta	35493|Streptophyta	O	Mitochondrial protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_15555_1	436308.Nmar_0348	1.16e-165	499.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_215357_1	570417.WP0947	2.26e-153	439.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,47F0S@766|Rickettsiales	766|Rickettsiales	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
k59_275348_1	1131266.ARWQ01000014_gene94	4.47e-100	293.0	COG2406@1|root,arCOG01093@2157|Archaea,41S6X@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Ferritin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin
k59_275348_2	1131266.ARWQ01000006_gene279	1.16e-69	214.0	arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
k59_314281_1	570417.WP0841	3.88e-181	510.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,47EVG@766|Rickettsiales	766|Rickettsiales	E	Aminotransferase	aatA	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_314281_2	570417.WP0843	1.57e-61	197.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,47EW4@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
k59_166091_1	7029.ACYPI061802-PA	8.33e-09	62.0	2D14R@1|root,2SGPM@2759|Eukaryota	7029.ACYPI061802-PA|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_275354_1	1229909.NSED_03865	1.41e-20	91.7	arCOG08796@1|root,arCOG08796@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_86290_1	7029.ACYPI007400-PA	1.88e-11	71.6	KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	ko:K10443	-	-	-	-	ko00000,ko04121	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_46308_1	1211777.BN77_0598	1.66e-07	52.4	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2U72X@28211|Alphaproteobacteria,4BEFF@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
k59_304045_1	436308.Nmar_1706	1.38e-89	275.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
k59_314294_1	1236908.wNo_03820	1.41e-15	74.7	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,47G30@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
k59_314294_2	570417.WP0718	2.04e-82	245.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,47FFR@766|Rickettsiales	766|Rickettsiales	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
k59_115179_1	1267535.KB906767_gene1973	0.000277	48.1	COG4584@1|root,COG4584@2|Bacteria,3Y630@57723|Acidobacteria	57723|Acidobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
k59_86306_1	419947.MRA_2353	5.59e-68	222.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,234KQ@1762|Mycobacteriaceae	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
k59_66389_1	1267535.KB906767_gene5393	1.83e-32	120.0	COG3415@1|root,COG3415@2|Bacteria,3Y8WI@57723|Acidobacteria	57723|Acidobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_33
k59_154874_1	6087.XP_004208487.1	8.54e-23	103.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa	33208|Metazoa	G	mannose metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_74336_1	261292.Nit79A3_1050	4.98e-59	194.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,372IM@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
k59_104626_1	290397.Adeh_0636	2.28e-44	156.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YXY8@29|Myxococcales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k59_275368_4	1693.BMIN_1398	7.71e-07	61.6	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CYVK@85004|Bifidobacteriales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k59_225188_1	7425.NV17450-PA	5.08e-83	299.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,46IFZ@7399|Hymenoptera	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_195458_1	338963.Pcar_1382	3.41e-36	125.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_Tnp_1
k59_125329_1	265072.Mfla_0299	5.29e-90	276.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,2KKX5@206350|Nitrosomonadales	206350|Nitrosomonadales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k59_175475_1	7237.FBpp0288099	1.91e-34	137.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,4556V@7147|Diptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_96544_1	436308.Nmar_0322	3.7e-19	86.3	COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	DBI_PRT
k59_96544_2	1131266.ARWQ01000001_gene1180	7.8e-107	325.0	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k59_233959_1	1459636.NTE_01100	1.2e-128	366.0	arCOG08699@1|root,arCOG08699@2157|Archaea,41S8N@651137|Thaumarchaeota	1459636.NTE_01100|-	C	PFAM Ammonia monooxygenase methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	-
k59_205254_1	7029.ACYPI067094-PA	3.37e-28	123.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_74346_1	552811.Dehly_1586	4.15e-80	248.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k59_25689_1	1236908.wNo_02580	4.36e-141	444.0	COG0085@1|root,COG0086@1|root,COG0085@2|Bacteria,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,47ETY@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_25689_2	570417.WP0553	1.78e-188	526.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,47ETX@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k59_36249_1	7029.ACYPI062999-PA	3.66e-47	169.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_215435_1	1236908.wNo_09370	1.46e-191	541.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,47ESZ@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_233972_1	570417.WP0847	1.87e-141	404.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,47F7P@766|Rickettsiales	766|Rickettsiales	GM	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase
k59_86353_1	7029.ACYPI070058-PA	9.63e-06	53.5	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_5313_1	926550.CLDAP_14930	2.44e-17	78.2	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi	200795|Chloroflexi	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
k59_195497_1	1217718.ALOU01000061_gene507	4.64e-41	145.0	COG1682@1|root,COG1682@2|Bacteria,1MUTE@1224|Proteobacteria,2VT6H@28216|Betaproteobacteria,1KFRW@119060|Burkholderiaceae	28216|Betaproteobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09688	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.101	-	-	ABC2_membrane
k59_225222_1	1236908.wNo_07640	9.94e-67	203.0	COG3027@1|root,COG3027@2|Bacteria	2|Bacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_125359_1	1298867.AUES01000008_gene5202	3.21e-56	202.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1
k59_275417_1	999541.bgla_1g03580	4.19e-109	349.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k59_25710_1	556269.ACDQ01000013_gene682	2.5e-90	273.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,473HD@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k59_56036_1	1459636.NTE_01634	9.8e-42	154.0	COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA primase	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
k59_86361_1	1415779.JOMH01000001_gene1545	4.75e-05	50.4	COG0642@1|root,COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	2.7.13.3	ko:K10819	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg,dCache_1
k59_86361_2	883126.HMPREF9710_04617	0.000558	43.5	COG4585@1|root,COG4585@2|Bacteria,1RBN9@1224|Proteobacteria,2VQ8I@28216|Betaproteobacteria,47658@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k59_146246_1	1380394.JADL01000012_gene856	7.74e-48	173.0	28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_176322_2	95619.PM1_0210055	2.51e-81	244.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
k59_176322_3	1120970.AUBZ01000013_gene1839	9.38e-10	58.5	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,466F4@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iE2348C_1286.E2348C_0457	Metallophos,Metallophos_2
k59_244592_1	1229909.NSED_06490	8.68e-95	303.0	COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
k59_206057_1	7029.ACYPI069407-PA	6.39e-200	647.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_74950_1	1236908.wNo_04160	6.23e-149	430.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,47F04@766|Rickettsiales	766|Rickettsiales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
k59_74950_2	570417.WP0754	1.04e-43	146.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,47F57@766|Rickettsiales	766|Rickettsiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
k59_97600_1	5037.XP_001542895.1	5.56e-22	100.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3P0R9@4751|Fungi,3R0XE@4890|Ascomycota,20JNN@147545|Eurotiomycetes,3B67D@33183|Onygenales	4751|Fungi	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_256023_1	653733.Selin_2000	8.04e-25	102.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
k59_256023_3	660470.Theba_1170	1.88e-07	53.9	2DNS7@1|root,32YWC@2|Bacteria	2|Bacteria	S	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k59_167214_1	27923.ML34051a-PA	8.69e-33	127.0	KOG1075@1|root,KOG1075@2759|Eukaryota,38VTY@33154|Opisthokonta,3BWAP@33208|Metazoa	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_142084_1	1229909.NSED_08980	3.46e-119	348.0	COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota	651137|Thaumarchaeota	F	aspartate carbamoyltransferase	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
k59_231340_1	570417.WP0524	8.39e-08	52.4	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,47F6Z@766|Rickettsiales	766|Rickettsiales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
k59_231340_2	1236908.wNo_01880	1.31e-119	343.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,47FFU@766|Rickettsiales	766|Rickettsiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
k59_92560_2	1123393.KB891317_gene2304	4.41e-84	258.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1KRBA@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
k59_112154_1	153948.NAL212_2521	1.01e-53	169.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,373D1@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k59_112154_2	76114.ebA1185	1.62e-19	87.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,2KUH8@206389|Rhodocyclales	206389|Rhodocyclales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k59_52320_1	570417.WP1000	1.18e-81	242.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,47FM0@766|Rickettsiales	766|Rickettsiales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
k59_291752_1	1236908.wNo_01310	1.07e-95	283.0	COG1100@1|root,COG1100@2|Bacteria,1N5QS@1224|Proteobacteria,2TSKW@28211|Alphaproteobacteria,47G3P@766|Rickettsiales	766|Rickettsiales	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_24
k59_291752_2	1236908.wNo_01300	2.18e-45	149.0	COG1595@1|root,COG1595@2|Bacteria,1RI42@1224|Proteobacteria,2UVC1@28211|Alphaproteobacteria,47GE4@766|Rickettsiales	766|Rickettsiales	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
k59_12314_1	159087.Daro_3514	4.59e-26	100.0	COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,2VVKY@28216|Betaproteobacteria,2M034@206389|Rhodocyclales	206389|Rhodocyclales	C	Nitrate reductase cytochrome c-type subunit (NapB)	-	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
k59_12314_2	1304883.KI912532_gene1557	6.66e-57	182.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VMSB@28216|Betaproteobacteria,2KV5G@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome c-type protein	-	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
k59_162416_1	1485544.JQKP01000007_gene1999	3.29e-70	228.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2VHCJ@28216|Betaproteobacteria,44V9H@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_122214_1	1121035.AUCH01000008_gene1003	4.78e-31	117.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
k59_172164_1	570417.WP0035	2.61e-108	332.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K18376	-	M00660	-	-	ko00000,ko00002,ko02044	1.C.65.1	-	-	DUF1542,Mob_Pre,Relaxase,YSIRK_signal
k59_12325_1	745014.OMB55_00019930	1.91e-16	84.3	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria	1224|Proteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_62248_1	163164.WD_0428	9.2e-21	83.2	COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UGGG@28211|Alphaproteobacteria,47FMN@766|Rickettsiales	766|Rickettsiales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
k59_62248_2	570417.WP0621	1.77e-88	262.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
k59_62248_3	570417.WP0620	1.08e-77	234.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,AsmA_2
k59_62248_4	570417.WP0619	1.22e-33	126.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,47F3U@766|Rickettsiales	766|Rickettsiales	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
k59_221781_1	859657.RPSI07_1369	1.94e-86	258.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1K15D@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
k59_221781_2	557598.LHK_00530	3.01e-84	259.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KPT9@206351|Neisseriales	206351|Neisseriales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k59_291783_1	883080.HMPREF9697_01684	5.93e-81	256.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,3JUBU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	MA20_34330	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_271871_1	1131266.ARWQ01000012_gene1609	1.82e-08	51.6	arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_251782_1	1236908.wNo_00470	8.31e-30	105.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,2VDAN@28211|Alphaproteobacteria,47FTE@766|Rickettsiales	766|Rickettsiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
k59_251782_2	570417.WP0075	1.52e-136	388.0	COG3932@1|root,COG3932@2|Bacteria,1MZD5@1224|Proteobacteria,2UD5A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	exopolysaccharide synthesis	-	-	-	-	-	-	-	-	-	-	-	-	ExoD
k59_251794_1	631454.N177_3820	7.58e-40	147.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,1JQCV@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
k59_182142_1	7245.FBpp0263216	1.11e-66	216.0	29FK7@1|root,2RNRY@2759|Eukaryota,38SFN@33154|Opisthokonta,3CD42@33208|Metazoa,3DUEZ@33213|Bilateria,42BUU@6656|Arthropoda,3SSBZ@50557|Insecta,457Q0@7147|Diptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_132445_1	1229909.NSED_07175	6.82e-96	289.0	COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota	651137|Thaumarchaeota	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
k59_291804_1	1121286.AUMT01000001_gene6	3.64e-14	77.8	COG2801@1|root,COG2801@2|Bacteria,4PA3A@976|Bacteroidetes,1IHEZ@117743|Flavobacteriia,3ZU42@59732|Chryseobacterium	976|Bacteroidetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_271901_1	570417.WP1264	1.01e-93	284.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,47F3Y@766|Rickettsiales	766|Rickettsiales	EGP	Major facilitator	proP6	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
k59_2232_1	10658.DPOL_BPPRD	3.26e-43	160.0	4QAWD@10239|Viruses,4QVNG@35237|dsDNA viruses  no RNA stage,4QHTW@10656|Tectiviridae	10656|Tectiviridae	L	DNA binding	-	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	-
k59_112229_1	313612.L8106_12555	1.76e-57	184.0	COG0457@1|root,COG0457@2|Bacteria,1G6S8@1117|Cyanobacteria,1HGG7@1150|Oscillatoriales	1117|Cyanobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
k59_291811_1	7425.NV30710-PA	3.19e-62	210.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_52380_1	7425.NV16462-PA	1.5e-16	87.4	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17
k59_231402_1	570417.WP1151	8.79e-246	685.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,47EWS@766|Rickettsiales	766|Rickettsiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
k59_2247_1	1469245.JFBG01000027_gene1495	5.57e-20	89.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
k59_2247_2	396588.Tgr7_1023	5.48e-35	121.0	COG4327@1|root,COG4327@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4212)	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	DUF4212
k59_101860_1	1459636.NTE_01342	1.94e-79	244.0	COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1
k59_311364_1	1443665.JACA01000013_gene4272	1.3e-42	148.0	COG4106@1|root,COG4106@2|Bacteria,4P2YF@976|Bacteroidetes,1I8SV@117743|Flavobacteriia,2YKN9@290174|Aquimarina	976|Bacteroidetes	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
k59_52387_1	570417.WP0474	7.35e-109	318.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,47F8J@766|Rickettsiales	766|Rickettsiales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
k59_52387_2	570417.WP0473	1.51e-58	188.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,47EXB@766|Rickettsiales	766|Rickettsiales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
k59_32626_1	570417.WP1204	3.8e-71	223.0	COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,2TRSC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18990	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_32626_2	570417.WP1204	3.86e-63	202.0	COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,2TRSC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18990	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
k59_211943_1	570417.WP0184	2.9e-127	370.0	COG1301@1|root,COG1301@2|Bacteria,1R3SN@1224|Proteobacteria,2U5UF@28211|Alphaproteobacteria,47F6X@766|Rickettsiales	766|Rickettsiales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
k59_211943_2	570417.WP0185	2.53e-138	391.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,47FPG@766|Rickettsiales	766|Rickettsiales	O	COG1214 Inactive homolog of metal-dependent proteases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M22
k59_211943_3	570417.WP0186	4.62e-76	229.0	COG0703@1|root,COG0703@2|Bacteria	2|Bacteria	F	shikimate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
k59_92666_1	1236908.wNo_05560	2.27e-149	427.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,47FAK@766|Rickettsiales	766|Rickettsiales	S	Permease	perM	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
k59_262759_1	1027273.GZ77_06905	1.35e-27	114.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,1SHHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_33520_1	570417.WP0632	7.56e-66	203.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,47FMQ@766|Rickettsiales	766|Rickettsiales	C	Cytochrome b561	cybB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
k59_33520_2	570417.WP0633	3.18e-99	295.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,47EX3@766|Rickettsiales	766|Rickettsiales	S	Enoyl-(Acyl-carrier-protein) reductase II	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
k59_212756_1	570417.WP1081	7.14e-166	466.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2TSQD@28211|Alphaproteobacteria,47EZ5@766|Rickettsiales	766|Rickettsiales	G	fructose-bisphosphate aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
k59_212756_2	1236908.wNo_06400	3.09e-75	230.0	2DRRR@1|root,33CS8@2|Bacteria,1NKF7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_133430_1	436308.Nmar_1409	2e-78	238.0	COG1094@1|root,arCOG04150@2157|Archaea,41SNG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	K homology RNA-binding domain	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
k59_282273_1	1236908.wNo_04840	1.43e-53	177.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,47F2H@766|Rickettsiales	766|Rickettsiales	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
k59_282273_2	1236908.wNo_04850	2.17e-91	277.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,47F6U@766|Rickettsiales	766|Rickettsiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
k59_123014_1	443143.GM18_3632	7.78e-54	177.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,42QS8@68525|delta/epsilon subdivisions,2WMV7@28221|Deltaproteobacteria,43SGZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
k59_23191_1	570417.WP0562	3.88e-170	492.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,47EWM@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k59_93561_1	7029.ACYPI087712-PA	1.09e-30	127.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3ATJT@33154|Opisthokonta,3C3T5@33208|Metazoa,3DJBA@33213|Bilateria	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_163354_1	868131.MSWAN_1117	9.91e-73	242.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23PEI@183925|Methanobacteria	28890|Euryarchaeota	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.6	ko:K01535,ko:K12952	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.23,3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
k59_212775_1	1236908.wNo_00190	1.66e-96	287.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K21439	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_183065_1	6334.EFV49853	5.55e-32	129.0	2CMP4@1|root,2QR56@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF1758,DUF1759,Peptidase_A17,Phlebovirus_G2,RVT_1,rve
k59_93569_1	1380387.JADM01000007_gene504	3.99e-12	65.9	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XI75@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the thiolase family	pcaF	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k59_93569_2	335284.Pcryo_1235	1.76e-30	120.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RPVB@1236|Gammaproteobacteria,3NIJY@468|Moraxellaceae	1236|Gammaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
k59_252680_1	436308.Nmar_0345	5.91e-32	121.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_241922_1	1287475.HMPREF1650_07740	2.46e-23	103.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,22JYP@1653|Corynebacteriaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenases	fadE25	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
k59_23218_1	1236908.wNo_07090	2.32e-169	482.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,47G49@766|Rickettsiales	766|Rickettsiales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
k59_3048_1	10224.XP_006822105.1	2e-38	145.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB3G@33154|Opisthokonta,3BQKC@33208|Metazoa,3D77Y@33213|Bilateria	33208|Metazoa	O	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	ko:K10577	ko03013,ko04064,ko04120,ko05206,map03013,map04064,map04120,map05206	M00427	-	-	ko00000,ko00001,ko00002,ko03019,ko04121	-	-	-	RVT_1
k59_63240_1	1131266.ARWQ01000002_gene674	0.0	929.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_232051_1	7029.ACYPI004323-PA	1.1e-33	133.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_113081_1	436308.Nmar_1649	5.14e-49	166.0	arCOG10597@1|root,arCOG10597@2157|Archaea	2157|Archaea	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_222639_2	1236908.wNo_10370	2.77e-107	327.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,47EZY@766|Rickettsiales	766|Rickettsiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
k59_163378_1	7425.NV10089-PA	7.76e-73	254.0	COG2319@1|root,KOG1075@1|root,KOG0309@2759|Eukaryota,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_23225_1	1415780.JPOG01000001_gene1540	4.24e-102	314.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1X45G@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k59_312128_1	1348657.M622_02415	8.92e-32	122.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales	206389|Rhodocyclales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k59_123056_1	1131266.ARWQ01000005_gene845	1.94e-41	142.0	COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
k59_123056_2	436308.Nmar_0537	2.26e-105	316.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
k59_83615_1	1236908.wNo_03100	5.54e-121	348.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,47G6A@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
k59_173078_1	570417.WP0787	2.27e-175	514.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Cu_amine_oxidN1
k59_232075_1	570417.WP0097	2.86e-130	393.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,47ETH@766|Rickettsiales	766|Rickettsiales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
k59_282340_1	570417.WP0558	8.71e-38	129.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria	1224|Proteobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
k59_282340_2	1236908.wNo_02630	6.7e-100	295.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,47F7X@766|Rickettsiales	766|Rickettsiales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
k59_3068_1	1459636.NTE_02229	7.36e-48	173.0	COG1239@1|root,arCOG00438@2157|Archaea	2157|Archaea	H	magnesium chelatase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5
k59_183130_1	1131266.ARWQ01000002_gene660	1.04e-48	163.0	COG0730@1|root,arCOG02050@2157|Archaea,41SKY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
k59_63285_1	7029.ACYPI071509-PA	1.27e-39	150.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,42AN1@6656|Arthropoda	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_83631_1	27923.ML046335a-PA	7.1e-09	62.4	COG0480@1|root,KOG1075@1|root,KOG0467@2759|Eukaryota,KOG1075@2759|Eukaryota,38B8Q@33154|Opisthokonta,3BEBA@33208|Metazoa	33208|Metazoa	J	elongation factor Tu	EFTUD1	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019637,GO:0019693,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042256,GO:0042278,GO:0043021,GO:0043022,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044877,GO:0046039,GO:0046128,GO:0046483,GO:0055086,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	-	ko:K14536	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
k59_232084_1	331869.BAL199_19753	1.28e-18	83.6	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UAQH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
k59_163421_1	1459636.NTE_01248	2.51e-97	292.0	COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_133530_1	244447.XP_008333619.1	4.23e-16	85.1	KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii	33208|Metazoa	S	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_63289_1	1131266.ARWQ01000002_gene489	1.54e-46	154.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k59_63289_2	436308.Nmar_0933	3.67e-17	78.2	COG1581@1|root,arCOG01753@2157|Archaea,41TA9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Alba	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
k59_202966_1	570417.WP0966	8.82e-113	346.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,47EYK@766|Rickettsiales	766|Rickettsiales	T	histidine kinase response regulator	dhkA	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
k59_252741_1	557436.Lreu_0151	1.12e-06	57.0	COG4974@1|root,COG4974@2|Bacteria,1TQST@1239|Firmicutes,4HPQC@91061|Bacilli,3F47D@33958|Lactobacillaceae	91061|Bacilli	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k59_102578_1	3712.Bo00613s140.1	8.8e-10	58.5	2E4T1@1|root,2SBN4@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_102578_2	3880.AES97352	1.13e-05	48.5	KOG4853@1|root,KOG4853@2759|Eukaryota,37UN2@33090|Viridiplantae,3GJA7@35493|Streptophyta	35493|Streptophyta	S	mitotic sister chromatid biorientation	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_152664_1	7029.ACYPI003180-PA	1.62e-41	157.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa,3D5JC@33213|Bilateria,41X08@6656|Arthropoda,3SJDR@50557|Insecta	33208|Metazoa	G	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.1.17	ko:K00699	ko00040,ko00053,ko00140,ko00830,ko00860,ko00980,ko00982,ko00983,ko01100,ko01110,ko05204,map00040,map00053,map00140,map00830,map00860,map00980,map00982,map00983,map01100,map01110,map05204	M00014,M00129	R01383,R02358,R02389,R02478,R02502,R02902,R03091,R04352,R04353,R04354,R04683,R07106,R08259,R08261,R08262,R08263,R08615,R09426,R09427,R09428	RC00005,RC00033,RC00049,RC00059,RC00078,RC00171,RC00397,RC00523,RC00529,RC00708,RC02748	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT1	-	Exo_endo_phos,Exo_endo_phos_2,PRE_C2HC,RVT_1
k59_282363_1	570417.WP1051	4.29e-18	89.4	COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gram_pos_anchor,LRR_5,YSIRK_signal,YadA_anchor,YadA_head,YadA_stalk
k59_23283_1	1131266.ARWQ01000001_gene1172	3.22e-08	53.9	COG1691@1|root,arCOG02465@2157|Archaea,41SCY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
k59_23283_2	1131266.ARWQ01000001_gene1173	1.68e-87	263.0	COG1814@1|root,arCOG01096@2157|Archaea,41T13@651137|Thaumarchaeota	651137|Thaumarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
k59_272882_2	1236908.wNo_05660	6.46e-97	291.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,47EYN@766|Rickettsiales	766|Rickettsiales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_113140_1	570417.WP0164	8.3e-269	738.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,47F80@766|Rickettsiales	766|Rickettsiales	H	Probable RNA and SrmB- binding site of polymerase A	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
k59_312187_1	570417.WP0138	2.31e-84	259.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	cystathionine	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
k59_312187_2	570417.WP0137	3.48e-70	226.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,47ESZ@766|Rickettsiales	766|Rickettsiales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k59_72523_1	3827.XP_004516035.1	1.77e-24	110.0	COG2801@1|root,KOG0017@2759|Eukaryota,388SY@33090|Viridiplantae,3GND2@35493|Streptophyta	35493|Streptophyta	L	DNA RNA polymerases superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	RVP_2,Retrotrans_gag,zf-CCHC
k59_163512_1	204773.HEAR1193	1.83e-40	143.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,475V5@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	soxA	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
k59_232126_1	1156919.QWC_09974	7.12e-20	99.0	COG0726@1|root,COG2304@1|root,COG2931@1|root,COG0726@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,3T4YM@506|Alcaligenaceae	28216|Betaproteobacteria	Q	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,He_PIG,HemolysinCabind,VWA_2
k59_133606_1	522306.CAP2UW1_1132	3.38e-87	281.0	29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_53378_1	7070.TC001491-PA	1.74e-45	167.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_252799_1	436308.Nmar_0348	3.75e-110	348.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_193107_1	1131266.ARWQ01000001_gene1251	4.56e-139	404.0	COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
k59_222737_1	7159.AAEL002957-PA	0.000421	48.1	COG0346@1|root,KOG2944@2759|Eukaryota	2759|Eukaryota	E	lactoylglutathione lyase activity	GLO1	GO:0001101,GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006089,GO:0006090,GO:0006355,GO:0006357,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0007275,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009414,GO:0009415,GO:0009438,GO:0009628,GO:0009636,GO:0009651,GO:0009889,GO:0009987,GO:0010035,GO:0010468,GO:0010556,GO:0010941,GO:0016020,GO:0016829,GO:0016846,GO:0019219,GO:0019222,GO:0019243,GO:0019752,GO:0019904,GO:0030097,GO:0030099,GO:0030154,GO:0030316,GO:0031323,GO:0031326,GO:0032501,GO:0032502,GO:0032787,GO:0033554,GO:0034641,GO:0042180,GO:0042182,GO:0042221,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0048513,GO:0048519,GO:0048523,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051186,GO:0051252,GO:0051596,GO:0051716,GO:0060255,GO:0060548,GO:0061727,GO:0065007,GO:0070887,GO:0071214,GO:0071470,GO:0071704,GO:0071944,GO:0080090,GO:0097237,GO:0098754,GO:0104004,GO:1901564,GO:1901575,GO:1901615,GO:1901700,GO:1903506,GO:1990748,GO:2000112,GO:2001141	4.4.1.5	ko:K01759,ko:K16803,ko:K21768	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000,ko03036,ko04812	-	-	-	Glyoxalase
k59_83727_2	1131266.ARWQ01000001_gene1302	4.09e-33	117.0	COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
k59_124346_1	436308.Nmar_0115	1.79e-37	137.0	COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
k59_124346_2	1229909.NSED_00270	3.68e-50	165.0	COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
k59_264411_1	1236908.wNo_00050	5.7e-87	256.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,47FJ5@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_264411_2	570417.WP0006	2.47e-24	94.7	COG0781@1|root,COG0781@2|Bacteria,1PRNA@1224|Proteobacteria,2VAAJ@28211|Alphaproteobacteria,47FSA@766|Rickettsiales	766|Rickettsiales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
k59_14591_1	1123500.ATUU01000003_gene1298	5.25e-59	196.0	COG0861@1|root,COG0861@2|Bacteria,1V1M1@1239|Firmicutes,4IRRE@91061|Bacilli	91061|Bacilli	P	Integral membrane protein TerC family	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
k59_135078_1	436308.Nmar_0291	1.28e-93	283.0	COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
k59_65080_1	7029.ACYPI52857-PA	6.93e-60	217.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_4361_1	570417.WP0926	3.06e-111	330.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,47F3Y@766|Rickettsiales	766|Rickettsiales	EGP	Major facilitator	proP6	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
k59_4361_2	1236908.wNo_06010	2e-196	543.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,47EVR@766|Rickettsiales	766|Rickettsiales	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
k59_184651_1	215803.DB30_8295	8.78e-203	572.0	COG2837@1|root,COG2837@2|Bacteria,1MXKF@1224|Proteobacteria,43801@68525|delta/epsilon subdivisions,2X39Y@28221|Deltaproteobacteria,2YV1P@29|Myxococcales	28221|Deltaproteobacteria	C	peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Dyp_perox
k59_174474_1	436308.Nmar_0959	6.86e-152	433.0	COG0059@1|root,arCOG04465@2157|Archaea,41S65@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
k59_194428_1	1408224.SAMCCGM7_c6618	2.8e-60	216.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9
k59_204308_1	1229909.NSED_08450	5.45e-73	218.0	COG1145@1|root,arCOG00291@2157|Archaea,41SNB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
k59_204308_2	436308.Nmar_1536	2.95e-35	133.0	COG0343@1|root,arCOG00989@2157|Archaea,41SF4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
k59_294174_1	1131266.ARWQ01000005_gene851	8.42e-23	97.1	COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Phosphomethylpyrimidine kinase	-	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K21219	ko00730,ko01100,map00730,map01100	-	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
k59_294174_2	436308.Nmar_0543	9.62e-41	146.0	COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein ThiC	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
k59_144447_1	97138.C820_02556	1.95e-14	73.2	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,36EVH@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
k59_294182_1	570417.WP0643	8.35e-116	350.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,47F1A@766|Rickettsiales	766|Rickettsiales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
k59_54822_1	7029.ACYPI52857-PA	3.24e-36	147.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,4221Z@6656|Arthropoda,3SQ77@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_24601_1	436308.Nmar_1628	7.57e-87	277.0	COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota	651137|Thaumarchaeota	FK	Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,HTH_20,NRDD
k59_164975_1	7070.TC016101-PA	1.61e-61	212.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQX5@50557|Insecta	33208|Metazoa	C	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.2.29	ko:K15407	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_45205_1	1229909.NSED_04325	2.99e-96	301.0	COG0046@1|root,arCOG00641@2157|Archaea,41S6S@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
k59_54823_1	1528098.NOVO_07925	6.28e-20	92.8	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	barA	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4388,HATPase_c,HisKA,Hpt,PAS_4,Response_reg
k59_109480_2	436308.Nmar_1234	2.83e-94	285.0	COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
k59_109491_1	436308.Nmar_1615	4.37e-09	54.7	COG0054@1|root,arCOG01323@2157|Archaea,41SQ6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
k59_109491_2	1229909.NSED_08735	1.45e-73	227.0	COG2429@1|root,arCOG04202@2157|Archaea,41SHK@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity	gch3	-	3.5.4.29	ko:K08096	ko00740,ko01100,map00740,map01100	-	R07306	RC01790	ko00000,ko00001,ko01000	-	-	-	GCH_III
k59_238219_1	7029.ACYPI073321-PA	9.61e-77	266.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_307977_1	330214.NIDE1309	7.22e-131	380.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_238235_1	1236908.wNo_07700	6.48e-53	176.0	COG0596@1|root,COG0596@2|Bacteria,1P0IP@1224|Proteobacteria	1224|Proteobacteria	S	Alpha beta hydrolase	sdbB	-	-	-	-	-	-	-	-	-	-	-	-
k59_248691_1	1411123.JQNH01000001_gene886	1.66e-83	266.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
k59_238324_1	391625.PPSIR1_38896	1.27e-27	116.0	COG3263@1|root,COG3263@2|Bacteria	2|Bacteria	P	cell volume homeostasis	cvrA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006884,GO:0008150,GO:0008324,GO:0008361,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0090066,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K03316,ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36,2.A.36.6	-	-	CorC_HlyC,Na_H_Exchanger,TrkA_C
k59_238324_2	1218084.BBJK01000073_gene5143	1.43e-05	46.6	2DM04@1|root,3139Z@2|Bacteria,1RFGB@1224|Proteobacteria,2VYTJ@28216|Betaproteobacteria,1KC6N@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
k59_238343_1	7029.ACYPI073321-PA	6.52e-17	87.4	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera	33208|Metazoa	O	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	Baculo_F,RVT_1,rve
k59_248763_2	870187.Thini_1378	6.51e-19	85.5	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
k59_248810_1	570417.WP0065	4e-46	157.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	PG_binding_1,SLH,Sel1
k59_308168_1	570417.WP0534	1.59e-134	381.0	COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria,47FK8@766|Rickettsiales	766|Rickettsiales	S	COQ9	-	-	-	ko:K18587	-	-	-	-	ko00000	-	-	-	COQ9
k59_79216_1	557598.LHK_02789	2.59e-41	152.0	COG0438@1|root,COG0438@2|Bacteria,1R56H@1224|Proteobacteria	1224|Proteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_308301_1	163164.WD_1071	4.43e-10	59.3	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,47EXV@766|Rickettsiales	766|Rickettsiales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
k59_308301_2	570417.WP0733	1.23e-36	136.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3
k59_308323_2	224325.AF_0993	1.28e-33	126.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2463P@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
k59_238575_1	570417.WP0039	1.85e-19	86.3	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,47FGX@766|Rickettsiales	766|Rickettsiales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_238575_2	570417.WP0038	1.89e-59	202.0	COG1511@1|root,COG1511@2|Bacteria	2|Bacteria	Q	domain protein	CP_1016	-	-	ko:K01421	-	-	-	-	ko00000	-	-	-	Effector_1
k59_249002_1	395494.Galf_0552	2.55e-95	310.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,44VNH@713636|Nitrosomonadales	28216|Betaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_79433_1	7070.TC006955-PA	1.04e-62	205.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CZSS@33213|Bilateria,41Y67@6656|Arthropoda,3SGFP@50557|Insecta	33208|Metazoa	L	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,Retrotrans_gag,rve,zf-H2C2
k59_79456_1	330214.NIDE1724	2.11e-81	258.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,DUF3494,Glug,TIG
k59_238650_1	511.JT27_07170	7.2e-64	201.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2VHMP@28216|Betaproteobacteria,3T41N@506|Alcaligenaceae	28216|Betaproteobacteria	GM	transporter ATP-binding protein	kpsT	-	3.6.3.38	ko:K09689	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101	-	-	ABC_tran
k59_238650_2	1424334.W822_04275	2.18e-10	65.1	COG3524@1|root,COG3524@2|Bacteria,1MUXV@1224|Proteobacteria,2VHVW@28216|Betaproteobacteria,3T9E6@506|Alcaligenaceae	28216|Betaproteobacteria	M	Capsule polysaccharide export	wcbD	-	-	ko:K10107	ko02010,map02010	M00249	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.101	-	-	-
k59_249057_1	570417.WP0722	1.28e-60	197.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TSV9@28211|Alphaproteobacteria,47EYE@766|Rickettsiales	766|Rickettsiales	E	Amino acid permease	potE	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_249057_2	570417.WP0723	1.25e-79	247.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TSV9@28211|Alphaproteobacteria,47EYE@766|Rickettsiales	766|Rickettsiales	E	Amino acid permease	potE	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
k59_249058_1	1236908.wNo_05880	4.02e-159	458.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,47EXT@766|Rickettsiales	766|Rickettsiales	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
k59_199503_1	1229909.NSED_06005	1.05e-18	84.7	arCOG03042@1|root,arCOG03042@2157|Archaea	2157|Archaea	KLT	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
k59_249378_1	1236908.wNo_02550	2.95e-16	77.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,47F37@766|Rickettsiales	766|Rickettsiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
k59_249378_2	570417.WP0550	6.68e-209	583.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,47G1Z@766|Rickettsiales	766|Rickettsiales	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
k59_209488_1	7159.AAEL005015-PA	7.46e-81	266.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VPS@33154|Opisthokonta,3C5ZM@33208|Metazoa,3DM1B@33213|Bilateria,42CJJ@6656|Arthropoda,3STFX@50557|Insecta,4582J@7147|Diptera,45M6U@7148|Nematocera	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_39910_2	1131266.ARWQ01000002_gene444	1.35e-105	314.0	COG0171@1|root,arCOG00069@2157|Archaea,41SJ9@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
k59_59870_1	1247726.MIM_c24810	1.24e-26	108.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2WAQC@28216|Betaproteobacteria,3T63Y@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_159625_1	570417.WP0639	3.3e-35	125.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2TRDY@28211|Alphaproteobacteria,47FDM@766|Rickettsiales	766|Rickettsiales	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	-	-	-	-	-	-	-	-	-	-	RmlD_sub_bind
k59_159625_2	570417.WP0640	4e-148	417.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2TTWP@28211|Alphaproteobacteria,47FDW@766|Rickettsiales	766|Rickettsiales	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
k59_79851_1	69319.XP_008553167.1	4.84e-31	125.0	2CWTA@1|root,2RV75@2759|Eukaryota,38WQJ@33154|Opisthokonta,3C6CU@33208|Metazoa,3DME6@33213|Bilateria,42CM4@6656|Arthropoda,3SY8M@50557|Insecta,46MJ3@7399|Hymenoptera	69319.XP_008553167.1|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_69857_1	640081.Dsui_1449	3.46e-99	311.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales	206389|Rhodocyclales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
k59_79858_1	1173028.ANKO01000006_gene2006	4.71e-05	52.0	COG0840@1|root,COG2202@1|root,COG3829@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,1GBFY@1117|Cyanobacteria,1HE1Q@1150|Oscillatoriales	1117|Cyanobacteria	T	Methyl-accepting chemotaxis sensory transducer with Pas Pac sensor	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PAS_4,PAS_9
k59_139706_1	7425.NV18508-PA	1.34e-27	117.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_149673_1	400682.PAC_15703732	2.54e-29	120.0	2CMP4@1|root,2QR56@2759|Eukaryota,38VE4@33154|Opisthokonta,3BR0W@33208|Metazoa	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17
k59_299296_1	7668.SPU_003909-tr	1.42e-10	67.4	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_79862_1	1236908.wNo_03140	1.37e-132	394.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,47EWY@766|Rickettsiales	766|Rickettsiales	I	Propionyl-CoA carboxylase alpha	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_159660_1	7425.NV18262-PA	2.88e-54	192.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_219519_1	1026882.MAMP_01338	1.39e-39	149.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,45ZVX@72273|Thiotrichales	72273|Thiotrichales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k59_219519_2	1123354.AUDR01000018_gene1203	1.31e-06	49.3	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1KRH5@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k59_69875_1	388401.RB2150_02784	1.41e-37	132.0	COG1765@1|root,COG1765@2|Bacteria,1PF5V@1224|Proteobacteria,2V4D4@28211|Alphaproteobacteria,3ZIN7@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_149681_1	6087.XP_004207470.1	5.2e-36	140.0	2CNBX@1|root,2QV3V@2759|Eukaryota,39W09@33154|Opisthokonta,3BH5J@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_149681_2	13249.RPRC004498-PA	2.22e-125	375.0	2CNBX@1|root,2QV3V@2759|Eukaryota,39W09@33154|Opisthokonta,3BH5J@33208|Metazoa,3E62V@33213|Bilateria,42B7K@6656|Arthropoda,3T0MX@50557|Insecta,3EEBZ@33342|Paraneoptera	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_10056_1	570417.WP0296	1.11e-212	604.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	ankA	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_189609_1	7425.NV30710-PA	3.2e-45	164.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda,3SH01@50557|Insecta	33208|Metazoa	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_209558_1	7425.NV17811-PA	3.92e-44	165.0	KOG1075@1|root,KOG1075@2759|Eukaryota	2759|Eukaryota	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RNase_H,RVT_1
k59_289374_1	391735.Veis_2330	8.55e-26	107.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,4AA51@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
k59_309327_1	1131266.ARWQ01000008_gene313	3.37e-126	373.0	COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
k59_129779_1	640512.BC1003_1515	9.11e-27	108.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1K1S0@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	arnB	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
k59_129779_2	267608.RSc1321	5.5e-125	365.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KIEQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
k59_149699_1	570417.WP0913	2.55e-159	477.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,47FZJ@766|Rickettsiales	766|Rickettsiales	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_219552_1	653948.CCA18274	1.91e-52	179.0	2CXRP@1|root,2RZ9M@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_Tnp_Tc3_1
k59_39996_1	62928.azo0389	1.41e-62	211.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KV59@206389|Rhodocyclales	206389|Rhodocyclales	I	poly(R)-hydroxyalkanoic acid synthase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
k59_79932_1	543728.Vapar_4492	2.14e-43	149.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria,4AERJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
k59_149706_1	1229909.NSED_08180	5.85e-45	145.0	COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
k59_149706_2	1229909.NSED_08175	1.62e-69	214.0	arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_79933_1	640081.Dsui_0675	9.49e-27	107.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,2KWSF@206389|Rhodocyclales	206389|Rhodocyclales	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
k59_79933_2	1288494.EBAPG3_27760	1.05e-09	59.3	COG3087@1|root,COG3087@2|Bacteria,1RIU5@1224|Proteobacteria,2VTKT@28216|Betaproteobacteria,3731K@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
k59_249475_1	7217.FBpp0123832	5.31e-27	120.0	2D7YD@1|root,2T7Y1@2759|Eukaryota,392BY@33154|Opisthokonta,3C7RU@33208|Metazoa,3DNS7@33213|Bilateria,4251S@6656|Arthropoda,3SUH8@50557|Insecta,457YM@7147|Diptera,45YQS@7214|Drosophilidae	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_249475_2	7029.ACYPI008451-PA	2.84e-152	503.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_75740_1	7176.CPIJ011340-PA	8.77e-14	74.3	KOG3515@1|root,KOG3515@2759|Eukaryota,38F8P@33154|Opisthokonta,3BN19@33208|Metazoa,3D374@33213|Bilateria,41Y36@6656|Arthropoda,3SRFP@50557|Insecta,459NI@7147|Diptera,45KNB@7148|Nematocera	33208|Metazoa	T	CD80-like C2-set immunoglobulin domain	igcm-1	GO:0000003,GO:0001654,GO:0001700,GO:0001736,GO:0001738,GO:0001745,GO:0001763,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002165,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005911,GO:0005912,GO:0005913,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007154,GO:0007155,GO:0007156,GO:0007163,GO:0007164,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007173,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007304,GO:0007306,GO:0007389,GO:0007391,GO:0007399,GO:0007423,GO:0007424,GO:0007444,GO:0007472,GO:0007476,GO:0007517,GO:0007552,GO:0007560,GO:0008150,GO:0008360,GO:0008365,GO:0009611,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009888,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009996,GO:0010453,GO:0010454,GO:0010646,GO:0010647,GO:0010648,GO:0010721,GO:0010927,GO:0016020,GO:0016021,GO:0016043,GO:0016318,GO:0016331,GO:0019953,GO:0022008,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030038,GO:0030054,GO:0030154,GO:0030703,GO:0030707,GO:0030855,GO:0031224,GO:0032501,GO:0032502,GO:0032504,GO:0032956,GO:0032970,GO:0032989,GO:0033043,GO:0035017,GO:0035018,GO:0035107,GO:0035114,GO:0035120,GO:0035146,GO:0035147,GO:0035157,GO:0035220,GO:0035239,GO:0035295,GO:0035330,GO:0035332,GO:0038127,GO:0040003,GO:0042058,GO:0042059,GO:0042060,GO:0042067,GO:0042335,GO:0042659,GO:0044085,GO:0044425,GO:0044464,GO:0044703,GO:0045595,GO:0045596,GO:0046843,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048563,GO:0048569,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048598,GO:0048609,GO:0048644,GO:0048646,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048749,GO:0048754,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051017,GO:0051093,GO:0051128,GO:0051239,GO:0051241,GO:0051493,GO:0051704,GO:0051716,GO:0051960,GO:0051961,GO:0060284,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061061,GO:0061138,GO:0061572,GO:0065007,GO:0065008,GO:0070161,GO:0071840,GO:0071944,GO:0090138,GO:0090596,GO:0097435,GO:0098609,GO:0098742,GO:1901184,GO:1901185,GO:1902531,GO:1902533,GO:2000026	-	ko:K06491,ko:K16680	ko04391,ko04514,ko05020,map04391,map04514,map05020	-	-	-	ko00000,ko00001,ko00536,ko00537,ko04090,ko04131,ko04516,ko04812	-	-	-	C2-set_2,I-set,Ig_2,Ig_3,V-set,fn3
k59_197525_1	7029.ACYPI56771-PA	6.72e-50	180.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,42AN1@6656|Arthropoda,3T03U@50557|Insecta	33208|Metazoa	S	Putative peptidase (DUF1758)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_245440_1	436308.Nmar_0099	9.81e-69	228.0	COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
k59_17437_1	570417.WP0706	2.03e-114	332.0	COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,2TSM7@28211|Alphaproteobacteria,47G0G@766|Rickettsiales	766|Rickettsiales	L	3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
k59_17437_2	1236908.wNo_03690	4.02e-204	565.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,47F6T@766|Rickettsiales	766|Rickettsiales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
k59_98793_1	7159.AAEL017378-PA	3.5e-17	85.9	COG0050@1|root,KOG0460@2759|Eukaryota,38BHM@33154|Opisthokonta,3BE5J@33208|Metazoa,3CUKG@33213|Bilateria,41VN7@6656|Arthropoda,3SFX6@50557|Insecta,4526Y@7147|Diptera,45GUA@7148|Nematocera	33208|Metazoa	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	TUFM	GO:0000278,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006996,GO:0007030,GO:0007049,GO:0008135,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009059,GO:0009295,GO:0009636,GO:0009987,GO:0010033,GO:0010256,GO:0010467,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0034641,GO:0034645,GO:0042221,GO:0042493,GO:0042645,GO:0043043,GO:0043170,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0046677,GO:0050896,GO:0070013,GO:0071704,GO:0071840,GO:0097159,GO:0097305,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901700	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k59_297184_1	1236908.wNo_03800	1.26e-162	468.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TSTS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type Fe3 transport system, permease component	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_106237_1	436308.Nmar_1794	3.65e-94	303.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
k59_68503_1	1131266.ARWQ01000010_gene56	1.11e-77	238.0	COG2123@1|root,arCOG01574@2157|Archaea,41SFZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
k59_68503_2	386456.JQKN01000001_gene1679	1.22e-08	55.5	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,23NWI@183925|Methanobacteria	183925|Methanobacteria	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
k59_187957_1	1131266.ARWQ01000005_gene810	1.1e-83	261.0	COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufD	-	-	-	ko:K09014,ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
k59_118725_1	7029.ACYPI55358-PA	6e-20	94.7	KOG1075@1|root,KOG1075@2759|Eukaryota,3AHY4@33154|Opisthokonta,3BXFH@33208|Metazoa,3DEI5@33213|Bilateria	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_118728_1	76114.ebA2478	5.49e-41	145.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k59_299044_1	580332.Slit_1713	1.99e-68	216.0	2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,2W0AA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_299044_2	713587.THITH_01410	5.88e-35	122.0	COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria,1WVWW@135613|Chromatiales	135613|Chromatiales	C	reductase beta subunit	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
k59_318021_2	163164.WD_0382	1.05e-61	212.0	COG2357@1|root,COG3391@1|root,COG2357@2|Bacteria,COG3391@2|Bacteria,1MXN7@1224|Proteobacteria,2TR83@28211|Alphaproteobacteria,47F3P@766|Rickettsiales	766|Rickettsiales	S	GTA TIM-barrel-like domain	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM,Phage-tail_3
k59_287664_1	7668.SPU_017551-tr	1.56e-05	52.4	2CYWU@1|root,2S6Y4@2759|Eukaryota,39VM9@33154|Opisthokonta,3BJ6W@33208|Metazoa,3DG6B@33213|Bilateria	33208|Metazoa	S	C-terminal of Roc, COR, domain	-	-	-	-	-	-	-	-	-	-	-	-	COR,Death,Roc
k59_179224_1	640081.Dsui_2814	1.24e-141	422.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
k59_247064_1	7425.NV18262-PA	6.51e-52	187.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_158302_1	1131266.ARWQ01000009_gene962	7.57e-20	88.6	COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
k59_158302_2	1131266.ARWQ01000009_gene961	4.09e-29	105.0	COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
k59_158302_3	1131266.ARWQ01000009_gene960	2.33e-29	105.0	COG2051@1|root,arCOG04108@2157|Archaea,41SUD@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
k59_77191_1	1236908.wNo_10780	1.41e-30	119.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,47EW5@766|Rickettsiales	766|Rickettsiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k59_77191_3	1236908.wNo_10770	3.73e-158	447.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	pagN	-	-	ko:K12980	-	-	-	-	ko00000,ko01005	-	-	-	Alginate_exp,OMP_b-brl
k59_29377_1	570417.WP0697	4.35e-116	334.0	COG5424@1|root,COG5424@2|Bacteria,1PV6D@1224|Proteobacteria,2V6N7@28211|Alphaproteobacteria,47F6F@766|Rickettsiales	766|Rickettsiales	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
k59_148974_1	1229909.NSED_01910	8.31e-23	96.7	COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k59_148974_2	436308.Nmar_0395	1.07e-46	155.0	COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
k59_279213_1	7029.ACYPI009216-PA	3.63e-68	242.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,42151@6656|Arthropoda,3SP6U@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_148983_1	570417.WP1379	1.75e-144	422.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2UF6P@28211|Alphaproteobacteria,47FE1@766|Rickettsiales	766|Rickettsiales	S	Ankyrin repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_148983_2	570417.WP0291	0.000592	42.7	COG5464@1|root,COG5464@2|Bacteria,1R8FS@1224|Proteobacteria,2UMP3@28211|Alphaproteobacteria,47FF8@766|Rickettsiales	766|Rickettsiales	S	to TIGR01784	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
k59_287693_1	436308.Nmar_0618	9.9e-79	257.0	COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k59_306634_1	7070.TC016102-PA	1.21e-84	296.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQX5@50557|Insecta	33208|Metazoa	C	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.4.2.29	ko:K15407	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	Exo_endo_phos_2,RVT_1
k59_29410_2	1504823.CCMM01000013_gene2292	3.04e-36	127.0	COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
k59_19469_1	67373.JOBF01000012_gene3995	3.84e-52	176.0	COG0715@1|root,COG0715@2|Bacteria,2IEVS@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
k59_287704_1	1158292.JPOE01000002_gene3653	2.03e-60	206.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1KJSP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_258877_1	396588.Tgr7_2163	2.66e-37	139.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria,1X258@135613|Chromatiales	135613|Chromatiales	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_208755_1	69319.XP_008557127.1	6.04e-13	73.9	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3SQJD@50557|Insecta,46JND@7399|Hymenoptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_149024_1	314345.SPV1_06994	1.59e-44	157.0	COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria	1224|Proteobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
k59_258909_1	439235.Dalk_1417	1.11e-08	57.0	COG1586@1|root,COG1586@2|Bacteria,1REQP@1224|Proteobacteria,42RVE@68525|delta/epsilon subdivisions,2WNJ5@28221|Deltaproteobacteria,2MJVH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	S-adenosylmethionine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	AdoMet_dc
k59_287737_1	7425.NV19133-PA	2.73e-09	66.2	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BI7U@33208|Metazoa,3CTS1@33213|Bilateria,41WYJ@6656|Arthropoda	33154|Opisthokonta	L	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve
k59_29459_1	570417.WP0156	2.08e-135	388.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,47EZ9@766|Rickettsiales	766|Rickettsiales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k59_299165_1	1459636.NTE_02737	3.35e-81	253.0	COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Replication factor C	-	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	DNA_pol3_delta2,Rep_fac_C,RuvB_N
k59_129022_1	1236908.wNo_00680	2.47e-122	358.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,47FGX@766|Rickettsiales	766|Rickettsiales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
k59_179345_1	570417.WP0731	6.44e-41	145.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	ank	-	3.5.1.2	ko:K01425,ko:K06867	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Ank_2,Ank_3,Ank_4,PIN_4,PRANC
k59_179345_2	570417.WP0731	0.00031	42.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	ank	-	3.5.1.2	ko:K01425,ko:K06867	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Ank_2,Ank_3,Ank_4,PIN_4,PRANC
k59_8698_1	78245.Xaut_1282	1.41e-10	60.8	COG0500@1|root,COG2226@2|Bacteria,1N9E8@1224|Proteobacteria,2UG3W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k59_118852_2	497321.C664_02995	1.92e-49	163.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2VSJY@28216|Betaproteobacteria,2KWJA@206389|Rhodocyclales	206389|Rhodocyclales	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
k59_236859_1	570417.WP0617	4.6e-160	465.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,47EWY@766|Rickettsiales	766|Rickettsiales	I	Propionyl-CoA carboxylase alpha	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
k59_236859_2	570417.WP0616	1.69e-98	291.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Astacin,SUFU
k59_158401_1	7070.TC016332-PA	5.56e-69	236.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BI8I@33208|Metazoa,3D5CW@33213|Bilateria,4224Q@6656|Arthropoda,3SQKC@50557|Insecta	33208|Metazoa	L	retrotransposable element Tf2 155 kDa protein type 1-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,rve
k59_29502_1	570417.WP0388	5.97e-28	111.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_4,Ank_5
k59_29502_2	163164.WD_0190	0.0	1158.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,47EZJ@766|Rickettsiales	766|Rickettsiales	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
k59_318207_1	1236908.wNo_11020	2.55e-187	521.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,47EY3@766|Rickettsiales	766|Rickettsiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k59_149119_1	570417.WP0603	2.08e-189	546.0	COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,47F23@766|Rickettsiales	766|Rickettsiales	U	type IV secretion system protein	virB4-1	-	-	ko:K03199	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	CagE_TrbE_VirB
k59_287807_1	887898.HMPREF0551_1867	6.13e-93	296.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1K1T3@119060|Burkholderiaceae	28216|Betaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
k59_306719_1	1288494.EBAPG3_22420	1.67e-156	453.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,372CV@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
k59_219365_1	570417.WP0602	3.91e-155	460.0	COG3704@1|root,COG3704@2|Bacteria,1N1KD@1224|Proteobacteria,2UDXI@28211|Alphaproteobacteria,47G3H@766|Rickettsiales	766|Rickettsiales	U	COG3704 Type IV secretory pathway, VirB6 components	virB6-1	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
k59_29536_1	1294273.roselon_00594	5.78e-11	70.1	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HemolysinCabind
k59_219366_1	1236908.wNo_01030	8.66e-117	375.0	COG0457@1|root,COG0666@1|root,COG1672@1|root,COG2931@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG1672@2|Bacteria,COG2931@2|Bacteria,1MWRF@1224|Proteobacteria,2U9VQ@28211|Alphaproteobacteria,47F2N@766|Rickettsiales	766|Rickettsiales	Q	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5,GerE,NB-ARC,TPR_12,TPR_2,TPR_7,TPR_8
k59_208891_1	7159.AAEL017224-PA	1.09e-08	60.5	COG2453@1|root,KOG2283@2759|Eukaryota,38CHA@33154|Opisthokonta,3BARF@33208|Metazoa,3CRCD@33213|Bilateria,41WWE@6656|Arthropoda,3SKKS@50557|Insecta,44ZB4@7147|Diptera,45I57@7148|Nematocera	33208|Metazoa	T	phosphatase activity. It is involved in the biological process described with protein dephosphorylation	PTEN	GO:0000003,GO:0000079,GO:0000902,GO:0000904,GO:0001525,GO:0001558,GO:0001568,GO:0001654,GO:0001655,GO:0001666,GO:0001667,GO:0001709,GO:0001745,GO:0001751,GO:0001754,GO:0001932,GO:0001933,GO:0001934,GO:0001944,GO:0001952,GO:0001953,GO:0001964,GO:0002020,GO:0002064,GO:0002065,GO:0002066,GO:0002119,GO:0002164,GO:0002165,GO:0002168,GO:0002252,GO:0002376,GO:0002682,GO:0002902,GO:0003006,GO:0003008,GO:0003674,GO:0003779,GO:0003824,GO:0004438,GO:0004721,GO:0004722,GO:0004725,GO:0005102,GO:0005161,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0006066,GO:0006355,GO:0006464,GO:0006469,GO:0006470,GO:0006508,GO:0006582,GO:0006629,GO:0006644,GO:0006650,GO:0006661,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006914,GO:0006928,GO:0006935,GO:0006950,GO:0006952,GO:0006955,GO:0006996,GO:0007009,GO:0007010,GO:0007154,GO:0007162,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007267,GO:0007268,GO:0007270,GO:0007272,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007346,GO:0007399,GO:0007409,GO:0007416,GO:0007417,GO:0007420,GO:0007423,GO:0007424,GO:0007425,GO:0007431,GO:0007435,GO:0007436,GO:0007507,GO:0007525,GO:0007552,GO:0007568,GO:0007610,GO:0007611,GO:0007613,GO:0007617,GO:0007618,GO:0007622,GO:0007623,GO:0007626,GO:0007635,GO:0008092,GO:0008104,GO:0008138,GO:0008150,GO:0008152,GO:0008283,GO:0008284,GO:0008285,GO:0008340,GO:0008360,GO:0008361,GO:0008366,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009266,GO:0009408,GO:0009605,GO:0009628,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009898,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009991,GO:0010001,GO:0010033,GO:0010243,GO:0010256,GO:0010259,GO:0010468,GO:0010469,GO:0010506,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010628,GO:0010631,GO:0010632,GO:0010633,GO:0010646,GO:0010647,GO:0010648,GO:0010660,GO:0010661,GO:0010662,GO:0010663,GO:0010665,GO:0010666,GO:0010717,GO:0010719,GO:0010720,GO:0010721,GO:0010769,GO:0010771,GO:0010810,GO:0010812,GO:0010883,GO:0010888,GO:0010941,GO:0010942,GO:0010948,GO:0010959,GO:0010975,GO:0010977,GO:0010997,GO:0014003,GO:0014066,GO:0014067,GO:0014706,GO:0016020,GO:0016043,GO:0016055,GO:0016202,GO:0016311,GO:0016314,GO:0016324,GO:0016358,GO:0016477,GO:0016579,GO:0016787,GO:0016788,GO:0016791,GO:0018958,GO:0019098,GO:0019216,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019637,GO:0019748,GO:0019751,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019953,GO:0021537,GO:0021542,GO:0021543,GO:0021700,GO:0021761,GO:0021766,GO:0021782,GO:0021953,GO:0021954,GO:0021955,GO:0022008,GO:0022010,GO:0022412,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022612,GO:0022898,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030029,GO:0030030,GO:0030036,GO:0030100,GO:0030154,GO:0030155,GO:0030162,GO:0030165,GO:0030182,GO:0030198,GO:0030258,GO:0030308,GO:0030334,GO:0030336,GO:0030424,GO:0030425,GO:0030534,GO:0030707,GO:0030850,GO:0030855,GO:0030900,GO:0031099,GO:0031102,GO:0031104,GO:0031175,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031329,GO:0031331,GO:0031344,GO:0031345,GO:0031396,GO:0031398,GO:0031399,GO:0031400,GO:0031401,GO:0031641,GO:0031642,GO:0031644,GO:0031645,GO:0031646,GO:0031647,GO:0031657,GO:0031658,GO:0031667,GO:0031974,GO:0031981,GO:0032006,GO:0032007,GO:0032101,GO:0032102,GO:0032103,GO:0032228,GO:0032268,GO:0032269,GO:0032270,GO:0032286,GO:0032291,GO:0032386,GO:0032388,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032989,GO:0032990,GO:0033032,GO:0033036,GO:0033157,GO:0033554,GO:0033555,GO:0033673,GO:0034593,GO:0034594,GO:0034613,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0035006,GO:0035010,GO:0035011,GO:0035069,GO:0035176,GO:0035206,GO:0035212,GO:0035239,GO:0035254,GO:0035255,GO:0035265,GO:0035272,GO:0035295,GO:0035335,GO:0035556,GO:0035690,GO:0035749,GO:0036211,GO:0036293,GO:0036294,GO:0036477,GO:0040007,GO:0040008,GO:0040011,GO:0040012,GO:0040013,GO:0040014,GO:0040015,GO:0040017,GO:0040024,GO:0042051,GO:0042052,GO:0042063,GO:0042127,GO:0042176,GO:0042221,GO:0042306,GO:0042307,GO:0042325,GO:0042326,GO:0042327,GO:0042330,GO:0042391,GO:0042440,GO:0042461,GO:0042462,GO:0042493,GO:0042552,GO:0042578,GO:0042592,GO:0042594,GO:0042711,GO:0042802,GO:0042981,GO:0042995,GO:0043005,GO:0043025,GO:0043062,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043086,GO:0043170,GO:0043197,GO:0043209,GO:0043217,GO:0043218,GO:0043220,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043266,GO:0043267,GO:0043269,GO:0043271,GO:0043408,GO:0043409,GO:0043410,GO:0043412,GO:0043434,GO:0043491,GO:0043542,GO:0043549,GO:0043550,GO:0043551,GO:0043553,GO:0043647,GO:0044057,GO:0044085,GO:0044087,GO:0044091,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044282,GO:0044297,GO:0044309,GO:0044320,GO:0044321,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044877,GO:0045017,GO:0045087,GO:0045165,GO:0045177,GO:0045202,GO:0045211,GO:0045471,GO:0045475,GO:0045595,GO:0045596,GO:0045597,GO:0045664,GO:0045665,GO:0045666,GO:0045732,GO:0045736,GO:0045786,GO:0045792,GO:0045806,GO:0045833,GO:0045843,GO:0045859,GO:0045862,GO:0045926,GO:0045930,GO:0045936,GO:0045937,GO:0046164,GO:0046174,GO:0046434,GO:0046474,GO:0046486,GO:0046488,GO:0046530,GO:0046620,GO:0046621,GO:0046626,GO:0046627,GO:0046677,GO:0046822,GO:0046824,GO:0046838,GO:0046839,GO:0046855,GO:0046856,GO:0048008,GO:0048167,GO:0048468,GO:0048477,GO:0048511,GO:0048512,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048580,GO:0048582,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048592,GO:0048608,GO:0048609,GO:0048634,GO:0048635,GO:0048638,GO:0048640,GO:0048646,GO:0048660,GO:0048662,GO:0048666,GO:0048667,GO:0048679,GO:0048681,GO:0048699,GO:0048707,GO:0048709,GO:0048731,GO:0048732,GO:0048738,GO:0048749,GO:0048812,GO:0048813,GO:0048814,GO:0048853,GO:0048854,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0048878,GO:0050678,GO:0050680,GO:0050764,GO:0050765,GO:0050767,GO:0050768,GO:0050769,GO:0050770,GO:0050771,GO:0050773,GO:0050774,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050803,GO:0050804,GO:0050805,GO:0050806,GO:0050807,GO:0050808,GO:0050821,GO:0050877,GO:0050890,GO:0050896,GO:0050905,GO:0050920,GO:0050921,GO:0050926,GO:0050927,GO:0051049,GO:0051050,GO:0051051,GO:0051090,GO:0051091,GO:0051093,GO:0051094,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051270,GO:0051271,GO:0051338,GO:0051347,GO:0051348,GO:0051438,GO:0051443,GO:0051547,GO:0051548,GO:0051602,GO:0051641,GO:0051674,GO:0051703,GO:0051704,GO:0051705,GO:0051716,GO:0051717,GO:0051726,GO:0051800,GO:0051893,GO:0051895,GO:0051896,GO:0051898,GO:0051960,GO:0051961,GO:0051962,GO:0052743,GO:0052744,GO:0052745,GO:0052866,GO:0055021,GO:0055022,GO:0055024,GO:0055026,GO:0055088,GO:0060024,GO:0060033,GO:0060043,GO:0060044,GO:0060070,GO:0060074,GO:0060134,GO:0060179,GO:0060255,GO:0060284,GO:0060291,GO:0060292,GO:0060322,GO:0060341,GO:0060420,GO:0060429,GO:0060537,GO:0060541,GO:0060548,GO:0060627,GO:0060736,GO:0060746,GO:0060996,GO:0060997,GO:0060998,GO:0061000,GO:0061001,GO:0061002,GO:0061024,GO:0061041,GO:0061045,GO:0061061,GO:0061062,GO:0061063,GO:0061065,GO:0061066,GO:0061117,GO:0061458,GO:0061564,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070228,GO:0070372,GO:0070373,GO:0070374,GO:0070482,GO:0070570,GO:0070571,GO:0070646,GO:0070647,GO:0070727,GO:0070851,GO:0070887,GO:0070925,GO:0071214,GO:0071236,GO:0071257,GO:0071310,GO:0071361,GO:0071375,GO:0071417,GO:0071453,GO:0071456,GO:0071495,GO:0071545,GO:0071704,GO:0071709,GO:0071711,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0080135,GO:0090066,GO:0090069,GO:0090071,GO:0090087,GO:0090109,GO:0090130,GO:0090132,GO:0090175,GO:0090219,GO:0090316,GO:0090342,GO:0090344,GO:0090394,GO:0090407,GO:0090596,GO:0097060,GO:0097061,GO:0097090,GO:0097105,GO:0097106,GO:0097107,GO:0097237,GO:0097305,GO:0097306,GO:0097447,GO:0097458,GO:0098552,GO:0098562,GO:0098590,GO:0098693,GO:0098698,GO:0098794,GO:0098815,GO:0098916,GO:0099054,GO:0099068,GO:0099084,GO:0099172,GO:0099173,GO:0099175,GO:0099177,GO:0099536,GO:0099537,GO:0104004,GO:0106017,GO:0106027,GO:0120025,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0140096,GO:0198738,GO:1900076,GO:1900077,GO:1900180,GO:1900182,GO:1901016,GO:1901017,GO:1901360,GO:1901379,GO:1901380,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901861,GO:1901862,GO:1901888,GO:1901889,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902041,GO:1902043,GO:1902074,GO:1902531,GO:1902532,GO:1902533,GO:1902806,GO:1902807,GO:1903034,GO:1903035,GO:1903050,GO:1903052,GO:1903121,GO:1903320,GO:1903322,GO:1903362,GO:1903364,GO:1903391,GO:1903392,GO:1903432,GO:1903506,GO:1903689,GO:1903690,GO:1903725,GO:1903726,GO:1903827,GO:1903829,GO:1903984,GO:1904029,GO:1904030,GO:1904062,GO:1904063,GO:1904262,GO:1904589,GO:1904591,GO:1904666,GO:1904668,GO:1904705,GO:1904706,GO:1904861,GO:1904951,GO:1905114,GO:1905330,GO:1905331,GO:1905809,GO:1905952,GO:1905953,GO:1990314,GO:1990381,GO:1990782,GO:2000026,GO:2000027,GO:2000045,GO:2000058,GO:2000060,GO:2000106,GO:2000112,GO:2000134,GO:2000145,GO:2000146,GO:2000171,GO:2000272,GO:2000463,GO:2000807,GO:2000808,GO:2001141,GO:2001233,GO:2001235,GO:2001236,GO:2001238	3.1.3.16,3.1.3.48,3.1.3.67	ko:K01110,ko:K18079	ko00562,ko01521,ko04068,ko04070,ko04071,ko04115,ko04140,ko04150,ko04151,ko04212,ko04218,ko04510,ko04931,ko05161,ko05165,ko05200,ko05206,ko05213,ko05214,ko05215,ko05218,ko05222,ko05224,ko05225,ko05230,map00562,map01521,map04068,map04070,map04071,map04115,map04140,map04150,map04151,map04212,map04218,map04510,map04931,map05161,map05165,map05200,map05206,map05213,map05214,map05215,map05218,map05222,map05224,map05225,map05230	-	R03363,R04513	RC00078	ko00000,ko00001,ko01000,ko01009	-	-	-	DSPc,PTEN_C2
k59_118907_1	436308.Nmar_1104	7.49e-121	371.0	COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota	651137|Thaumarchaeota	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k59_306730_1	1266925.JHVX01000001_gene2507	3.86e-113	340.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,372BT@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k59_287830_1	1131266.ARWQ01000006_gene220	1.19e-73	227.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
k59_8767_1	1266925.JHVX01000009_gene151	4.34e-102	317.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,372I1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_118934_1	7091.BGIBMGA011035-TA	7.24e-40	150.0	COG2801@1|root,KOG0017@2759|Eukaryota,38VNK@33154|Opisthokonta,3CB3V@33208|Metazoa,3DSCG@33213|Bilateria,428FM@6656|Arthropoda,3SSDK@50557|Insecta,44A45@7088|Lepidoptera	33208|Metazoa	L	gag-polypeptide of LTR copia-type	-	-	-	-	-	-	-	-	-	-	-	-	Retrotran_gag_2
k59_219388_1	570417.WP0658	4.28e-163	487.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,47EWP@766|Rickettsiales	766|Rickettsiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
k59_309854_1	570417.WP0542	0.0	885.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,47G15@766|Rickettsiales	766|Rickettsiales	F	bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k59_70380_1	7237.FBpp0273954	8.09e-20	101.0	2D3NG@1|root,2SS56@2759|Eukaryota,3960H@33154|Opisthokonta,3C3FT@33208|Metazoa,3DRK5@33213|Bilateria,423YG@6656|Arthropoda	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4780,Exo_endo_phos_2
k59_20643_1	1229909.NSED_08315	6.77e-113	327.0	COG1890@1|root,arCOG04186@2157|Archaea,41SM9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
k59_40656_1	1131266.ARWQ01000001_gene1153	2.66e-108	336.0	COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
k59_250036_6	696369.KI912183_gene1065	2.12e-10	69.7	COG0500@1|root,COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2226@2|Bacteria,1V06G@1239|Firmicutes,247WU@186801|Clostridia,265WK@186807|Peptococcaceae	186801|Clostridia	MQ	Methyltransferase domain	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,Methyltransf_23
k59_100397_1	743722.Sph21_2847	9.74e-35	139.0	COG3385@1|root,COG3385@2|Bacteria,4NHKV@976|Bacteroidetes,1J161@117747|Sphingobacteriia	976|Bacteroidetes	L	Domain of unknown function (DUF4372)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
k59_200307_1	1236908.wNo_06360	1.76e-93	283.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,47EVP@766|Rickettsiales	766|Rickettsiales	L	COG0513 Superfamily II DNA and RNA helicases	rhlE	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
k59_200307_2	1236908.wNo_06350	1.1e-53	168.0	COG1278@1|root,COG1278@2|Bacteria	2|Bacteria	K	Cold shock	cspB_1	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
k59_60581_1	1000565.METUNv1_04050	1.55e-09	57.4	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
k59_30740_1	436308.Nmar_1490	1.54e-109	323.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k59_260128_1	106582.XP_004570078.1	1.14e-52	189.0	COG2801@1|root,KOG4585@1|root,KOG0017@2759|Eukaryota,KOG4585@2759|Eukaryota,39THK@33154|Opisthokonta,3BGF1@33208|Metazoa,3D09T@33213|Bilateria,48E2J@7711|Chordata,49BQC@7742|Vertebrata,4A3KG@7898|Actinopterygii	33208|Metazoa	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4
k59_279941_1	400682.PAC_15723685	1.37e-54	197.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AK7D@33154|Opisthokonta,3BPZQ@33208|Metazoa	33208|Metazoa	T	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2,Exo_endo_phos_2,RVT_1
k59_30746_2	1380394.JADL01000005_gene5674	2.13e-76	234.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2TS1B@28211|Alphaproteobacteria,2JTGR@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
k59_190309_1	570417.WP1143	6.18e-99	292.0	COG0819@1|root,COG0819@2|Bacteria	2|Bacteria	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	tenA	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
k59_260137_1	748247.AZKH_0540	8.55e-67	207.0	COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2VMAI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
k59_290050_1	7029.ACYPI008451-PA	2.51e-18	97.1	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_290050_2	7029.ACYPI28832-PA	3.68e-141	459.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa	33208|Metazoa	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_70412_1	1131730.BAVI_17667	2.54e-08	59.7	COG2267@1|root,COG2267@2|Bacteria,1UJEV@1239|Firmicutes,4IT9N@91061|Bacilli,1ZSAM@1386|Bacillus	91061|Bacilli	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k59_239973_1	1459636.NTE_02229	1.2e-78	250.0	COG1239@1|root,arCOG00438@2157|Archaea	2157|Archaea	H	magnesium chelatase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5
k59_110552_1	69279.BG36_02095	3.09e-25	98.6	COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2U7E3@28211|Alphaproteobacteria,43M0G@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
k59_110552_2	28229.ND2E_4205	1.72e-16	79.0	COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,1RSHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
k59_270087_1	7029.ACYPI004757-PA	2.95e-82	285.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39XVS@33154|Opisthokonta,3BM3S@33208|Metazoa,3DD47@33213|Bilateria,421YB@6656|Arthropoda,3SM8V@50557|Insecta,3ECWM@33342|Paraneoptera	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_260139_1	509191.AEDB02000104_gene3791	8.66e-05	51.2	COG0666@1|root,COG0666@2|Bacteria,1URXN@1239|Firmicutes,259VC@186801|Clostridia,3WQRY@541000|Ruminococcaceae	186801|Clostridia	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_200336_1	321332.CYB_1256	6.41e-70	234.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YS@1117|Cyanobacteria,1GYPF@1129|Synechococcus	1117|Cyanobacteria	O	hmm pf07719	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,Sulfotransfer_2,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
k59_120517_1	1038860.AXAP01000008_gene5975	0.000409	48.1	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2TQMK@28211|Alphaproteobacteria,3JU2S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
k59_239976_1	864073.HFRIS_009844	5.17e-99	314.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,473U5@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
k59_270094_1	1131266.ARWQ01000030_gene989	4e-15	70.9	COG0066@1|root,arCOG02230@2157|Archaea,41SIA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	3-isopropylmalate dehydratase, small subunit	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
k59_270094_2	1229909.NSED_02185	3.25e-88	270.0	COG0065@1|root,arCOG01698@2157|Archaea,41S7A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_90661_1	1236908.wNo_02030	2.14e-73	228.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2V4N3@28211|Alphaproteobacteria,47FYJ@766|Rickettsiales	766|Rickettsiales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_90661_2	1236908.wNo_02040	8.83e-53	174.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,47FV3@766|Rickettsiales	766|Rickettsiales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
k59_10756_1	1229909.NSED_00835	1.09e-106	322.0	COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Vinylacetyl-CoA Delta-isomerase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
k59_100432_1	1236908.wNo_02020	4.81e-137	395.0	COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,2U6FF@28211|Alphaproteobacteria,47FIT@766|Rickettsiales	766|Rickettsiales	G	Sugar phosphate permease	uhpC	-	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	-	MFS_1
k59_30770_1	43151.ADAC007967-PA	1.6e-56	204.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,429UH@6656|Arthropoda,3T0UB@50557|Insecta,458R2@7147|Diptera	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_220189_1	1229909.NSED_06530	2.11e-47	161.0	arCOG08764@1|root,arCOG08764@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_220189_2	1229909.NSED_06760	1.89e-10	61.2	arCOG08689@1|root,arCOG08689@2157|Archaea,41T5U@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_30779_1	1231391.AMZF01000037_gene574	1.37e-74	245.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,3T8SC@506|Alcaligenaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_160575_1	1229909.NSED_00870	1.99e-58	194.0	COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
k59_10778_1	1236908.wNo_05050	2.16e-218	606.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,47ETR@766|Rickettsiales	766|Rickettsiales	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
k59_250115_1	1123257.AUFV01000007_gene186	5.64e-56	184.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1X34A@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the class I fructose-bisphosphate aldolase family	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
k59_250115_2	1266925.JHVX01000007_gene2288	9.82e-07	49.3	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,371NE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
k59_30793_1	570417.WP0816	1.28e-37	133.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2URBC@28211|Alphaproteobacteria,47G6K@766|Rickettsiales	766|Rickettsiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
k59_140465_1	1459636.NTE_00450	8.27e-21	87.0	COG1813@1|root,arCOG01863@2157|Archaea	2157|Archaea	K	transcription factor, homolog of eukaryotic MBF1	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
k59_20747_1	7425.NV20141-PA	3.31e-25	112.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3AB6K@33154|Opisthokonta,3BUWN@33208|Metazoa	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_260208_1	457415.HMPREF1006_02713	1.85e-36	139.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	ltrA	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1
k59_150380_1	640081.Dsui_0227	3.31e-166	493.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k59_80807_1	570417.WP0605	2.78e-146	424.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,47ESY@766|Rickettsiales	766|Rickettsiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
k59_30810_2	1231391.AMZF01000094_gene104	1.09e-13	70.9	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	hpcH	-	2.7.7.38,4.1.2.20,4.1.2.52	ko:K00979,ko:K01630,ko:K02510	ko00053,ko00350,ko00540,ko01100,ko01120,map00053,map00350,map00540,map01100,map01120	M00063	R01645,R01647,R02754,R03277,R03351,R11396	RC00152,RC00307,RC00435,RC00572,RC00574,RC00910,RC03057	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HpcH_HpaI
k59_210302_1	1236959.BAMT01000006_gene244	1.43e-37	139.0	COG0457@1|root,COG0457@2|Bacteria,1RKBG@1224|Proteobacteria,2VQFW@28216|Betaproteobacteria,2KMV8@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_311008_1	159087.Daro_1050	3.36e-34	123.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,2KX5X@206389|Rhodocyclales	206389|Rhodocyclales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_61904_1	702113.PP1Y_AT12267	3.02e-10	57.8	2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_51967_1	640081.Dsui_1649	7.72e-30	112.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,2KX5X@206389|Rhodocyclales	206389|Rhodocyclales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
k59_51967_2	595537.Varpa_5207	9.5e-90	273.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria,4AC49@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
k59_261508_1	7070.TC010973-PA	1.09e-14	74.7	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T04Y@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,RVT_1,rve
k59_42179_1	1229909.NSED_09535	4.42e-60	189.0	COG0237@1|root,arCOG01045@2157|Archaea,41SI8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
k59_92163_1	7159.AAEL017299-PA	8.06e-39	154.0	COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,41UI4@6656|Arthropoda,3SINP@50557|Insecta,4500E@7147|Diptera,45KJX@7148|Nematocera	33208|Metazoa	I	AMP-binding enzyme C-terminal domain	ACSF2	GO:0003674,GO:0003824,GO:0003996,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
k59_221409_1	269799.Gmet_1467	3.81e-28	110.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2X60E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
k59_71429_1	314270.RB2083_2624	1.45e-47	163.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQV0@28211|Alphaproteobacteria,3ZGRW@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	C	NADH flavin	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
k59_71429_2	795666.MW7_0656	3.74e-14	71.6	COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VHIY@28216|Betaproteobacteria,1K1EH@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Taurine catabolism dioxygenase TauD TfdA	-	-	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920	-	R05320	RC01331	ko00000,ko00001,ko01000	-	-	-	TauD
k59_82140_3	1342301.JASD01000008_gene1762	0.000961	47.0	COG2227@1|root,COG2227@2|Bacteria,1QXW6@1224|Proteobacteria,2VF8A@28211|Alphaproteobacteria,3ZZGV@60136|Sulfitobacter	28211|Alphaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_82140_4	1444711.CCJF01000005_gene1785	6.83e-22	98.6	COG0463@1|root,COG0463@2|Bacteria,2JGQ2@204428|Chlamydiae	204428|Chlamydiae	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k59_211503_2	1120999.JONM01000023_gene3186	1.47e-37	130.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,2KRJ1@206351|Neisseriales	206351|Neisseriales	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
k59_185591_1	335543.Sfum_3497	1.01e-49	174.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k59_136073_1	1124780.ANNU01000022_gene2963	1.02e-27	112.0	COG3677@1|root,COG3677@2|Bacteria,4NPDE@976|Bacteroidetes,47U28@768503|Cytophagia	976|Bacteroidetes	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,Transposase_mut
k59_74197_1	1229909.NSED_01675	1.28e-65	222.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k59_74197_2	1229909.NSED_01670	4.24e-66	223.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_215254_1	570417.WP0554	3.01e-250	756.0	COG0085@1|root,COG0086@1|root,COG0085@2|Bacteria,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,47ETY@766|Rickettsiales	766|Rickettsiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k59_175314_1	7070.TC015470-PA	5.26e-56	201.0	COG2801@1|root,KOG1922@1|root,KOG0017@2759|Eukaryota,KOG1922@2759|Eukaryota,38C7D@33154|Opisthokonta,3BDNK@33208|Metazoa,3CX9J@33213|Bilateria,41VES@6656|Arthropoda,3SHX8@50557|Insecta	33208|Metazoa	TZ	Actin binding. It is involved in the biological process described with cellular component organization	FHDC1	GO:0001763,GO:0002009,GO:0002064,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005884,GO:0007275,GO:0007424,GO:0008092,GO:0008150,GO:0009653,GO:0009888,GO:0009987,GO:0015629,GO:0030154,GO:0030855,GO:0031110,GO:0031113,GO:0031941,GO:0032092,GO:0032271,GO:0032501,GO:0032502,GO:0032886,GO:0032991,GO:0033043,GO:0035146,GO:0035147,GO:0035150,GO:0035239,GO:0035295,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043393,GO:0044087,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0048468,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051128,GO:0051493,GO:0060429,GO:0060446,GO:0060541,GO:0060562,GO:0061138,GO:0065007,GO:0065008,GO:0065009,GO:0070507,GO:0090066,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:1902903,GO:1904529,GO:1904531,GO:1904616,GO:1904618	-	-	-	-	-	-	-	-	-	-	Drf_FH3,FH2
k59_195277_4	1175654.A0A0S0MVN0_9CAUD	4.17e-37	141.0	4QFED@10239|Viruses,4R072@35237|dsDNA viruses  no RNA stage,4QPEH@28883|Caudovirales,4QN2V@10699|Siphoviridae	10699|Siphoviridae	S	tRNA modification	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_195277_7	1303518.CCALI_00090	3.4e-43	149.0	COG0302@1|root,COG0302@2|Bacteria	2|Bacteria	H	gtp cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c	GTP_cyclohydroI
k59_195277_8	869210.Marky_0657	2.44e-41	147.0	COG0602@1|root,COG0602@2|Bacteria,1WKI7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
k59_195277_9	1439940.BAY1663_01900	1.23e-23	96.7	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	synthase	queD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	iECIAI39_1322.ECIAI39_2947,iUTI89_1310.UTI89_C3129,ic_1306.c3324	PTPS
k59_195277_10	266940.Krad_4383	1.71e-50	167.0	COG1738@1|root,COG1738@2|Bacteria,2IGCP@201174|Actinobacteria	201174|Actinobacteria	S	Putative vitamin uptake transporter	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
k59_195277_11	530564.Psta_1038	8.04e-60	191.0	COG0603@1|root,COG0603@2|Bacteria,2IXBD@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	-	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
k59_314184_1	330214.NIDE0837	9.18e-141	418.0	COG2838@1|root,COG2838@2|Bacteria	2|Bacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
k59_5162_1	436308.Nmar_1545	1.94e-97	315.0	COG1404@1|root,arCOG00704@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
k59_205113_1	5270.UM04408P0	3.09e-24	106.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3V2N5@5204|Basidiomycota	4751|Fungi	L	Retrotransposon gag protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_225035_1	570417.WP0789	8.84e-130	384.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria,47EWN@766|Rickettsiales	766|Rickettsiales	V	alkaline protease secretion ATP-binding protein	aprD	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k59_165966_1	1123258.AQXZ01000019_gene3183	1.28e-17	87.8	COG4733@1|root,COG4733@2|Bacteria,2GMKC@201174|Actinobacteria	201174|Actinobacteria	S	fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
k59_25545_1	7159.AAEL017571-PA	2.87e-66	222.0	29KAX@1|root,2RTJT@2759|Eukaryota,38VQU@33154|Opisthokonta,3C60K@33208|Metazoa,3DM2E@33213|Bilateria,42341@6656|Arthropoda,3SRPZ@50557|Insecta	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_275253_1	7029.ACYPI29951-PA	2.26e-06	54.7	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_136121_1	436308.Nmar_1069	9.56e-129	374.0	COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
k59_205124_1	1121035.AUCH01000008_gene999	1.71e-77	248.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,2KUF7@206389|Rhodocyclales	206389|Rhodocyclales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
k59_265353_1	7176.CPIJ019125-PA	3.33e-19	94.4	COG1131@1|root,KOG0061@2759|Eukaryota,38CVQ@33154|Opisthokonta,3BMMP@33208|Metazoa,3D2T5@33213|Bilateria,41X63@6656|Arthropoda,3SIBB@50557|Insecta,4510V@7147|Diptera,45H0R@7148|Nematocera	33208|Metazoa	Q	ABC-2 type transporter	-	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015248,GO:0015318,GO:0015399,GO:0015405,GO:0015850,GO:0015918,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017127,GO:0022804,GO:0022857,GO:0030301,GO:0031224,GO:0033036,GO:0034040,GO:0034041,GO:0042623,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1901618	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran
k59_295068_2	7029.ACYPI063476-PA	4.35e-05	47.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_55816_1	7222.FBpp0158731	3.38e-28	114.0	COG5160@1|root,KOG0778@2759|Eukaryota,38HPZ@33154|Opisthokonta,3BCKW@33208|Metazoa,3CYJ0@33213|Bilateria,41XJI@6656|Arthropoda,3SGUT@50557|Insecta,450SV@7147|Diptera,45T7J@7214|Drosophilidae	33208|Metazoa	O	Cysteine-type peptidase activity. It is involved in the biological process described with proteolysis	SENP1	GO:0002682,GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005912,GO:0005924,GO:0005925,GO:0006282,GO:0006355,GO:0006357,GO:0006464,GO:0006508,GO:0006807,GO:0006915,GO:0006919,GO:0007154,GO:0007165,GO:0007275,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008234,GO:0009790,GO:0009792,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0010724,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012501,GO:0012505,GO:0016020,GO:0016787,GO:0016925,GO:0016926,GO:0016929,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019538,GO:0019783,GO:0023052,GO:0030054,GO:0030055,GO:0030162,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031965,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032268,GO:0032269,GO:0032270,GO:0032434,GO:0032435,GO:0032446,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0036211,GO:0042176,GO:0042177,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043280,GO:0043281,GO:0043412,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045595,GO:0045637,GO:0045646,GO:0045739,GO:0045861,GO:0045862,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048856,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051336,GO:0051345,GO:0051716,GO:0052547,GO:0052548,GO:0060255,GO:0061136,GO:0065007,GO:0065008,GO:0065009,GO:0070011,GO:0070013,GO:0070122,GO:0070137,GO:0070138,GO:0070139,GO:0070140,GO:0070161,GO:0070646,GO:0070647,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0097190,GO:0140096,GO:1901564,GO:1901799,GO:1902680,GO:1903050,GO:1903051,GO:1903362,GO:1903363,GO:1903506,GO:1903508,GO:1903706,GO:1904331,GO:1904333,GO:2000026,GO:2000058,GO:2000059,GO:2000112,GO:2000116,GO:2000278,GO:2000573,GO:2001020,GO:2001022,GO:2001056,GO:2001141	3.4.22.68	ko:K08592	-	-	-	-	ko00000,ko01000,ko01002,ko04121	-	-	-	Peptidase_C48
k59_5182_1	370438.PTH_2412	8.07e-15	76.3	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,2644N@186807|Peptococcaceae	186801|Clostridia	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k59_86233_1	570417.WP1364	7.18e-120	350.0	COG3039@1|root,COG3039@2|Bacteria,1RBRB@1224|Proteobacteria,2U6SM@28211|Alphaproteobacteria,47F69@766|Rickettsiales	766|Rickettsiales	L	IS2 (IS982-family)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
k59_125201_1	756272.Plabr_1727	1.23e-39	142.0	COG1943@1|root,COG1943@2|Bacteria,2J110@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k59_115093_1	436308.Nmar_1751	3.73e-137	395.0	COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Tyrosine--tRNA ligase	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
k59_205133_1	400682.PAC_15698949	8.88e-72	231.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa	33208|Metazoa	OU	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1,gag-asp_proteas,rve
k59_66251_1	7029.ACYPI56825-PA	1.52e-84	281.0	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3DDWX@33213|Bilateria,42228@6656|Arthropoda,3SPN5@50557|Insecta,3ED9B@33342|Paraneoptera	33208|Metazoa	L	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	RVP,RVT_1,Retrotrans_gag,rve,zf-CCHC
k59_265368_1	330214.NIDE4027	5.67e-55	177.0	COG1076@1|root,COG1076@2|Bacteria,3J1CS@40117|Nitrospirae	40117|Nitrospirae	O	DnaJ molecular chaperone homology domain	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	-
k59_104538_1	572477.Alvin_1010	3.34e-08	55.8	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1WYEZ@135613|Chromatiales	135613|Chromatiales	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
k59_5195_1	7029.ACYPI062997-PA	4.79e-28	117.0	KOG1075@1|root,KOG1075@2759|Eukaryota,3ATJT@33154|Opisthokonta,3C3T5@33208|Metazoa,3DJBA@33213|Bilateria	33208|Metazoa	S	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
k59_156129_1	3988.XP_002538363.1	5.16e-65	203.0	2EQXY@1|root,2STUY@2759|Eukaryota	2759|Eukaryota	S	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	UDPG_MGDP_dh
k59_156129_2	887898.HMPREF0551_2371	2.29e-13	69.7	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2VMEP@28216|Betaproteobacteria,1K9ZA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	bplA	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k59_137990_1	1236908.wNo_06930	1.15e-80	253.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,47EYV@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k59_137990_2	163164.WD_0968	2.51e-65	211.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,47EU0@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
k59_187440_1	7159.AAEL014270-PA	7.7e-13	76.3	KOG2510@1|root,KOG2510@2759|Eukaryota,3AF29@33154|Opisthokonta,3BX0U@33208|Metazoa,3DER0@33213|Bilateria,4225P@6656|Arthropoda,3SK8J@50557|Insecta,4524T@7147|Diptera,45D85@7148|Nematocera	33208|Metazoa	B	ionotropic glutamate receptor activity	-	GO:0003008,GO:0003674,GO:0005215,GO:0005216,GO:0005575,GO:0006810,GO:0006811,GO:0007600,GO:0007606,GO:0008150,GO:0009593,GO:0015075,GO:0015267,GO:0015276,GO:0015318,GO:0016020,GO:0016021,GO:0022803,GO:0022834,GO:0022836,GO:0022838,GO:0022839,GO:0022857,GO:0031224,GO:0032501,GO:0034220,GO:0042221,GO:0044425,GO:0050877,GO:0050896,GO:0050906,GO:0050907,GO:0051179,GO:0051234,GO:0051606,GO:0055085	-	-	-	-	-	-	-	-	-	-	Lig_chan,Lig_chan-Glu_bd,SBP_bac_3
k59_206577_1	436308.Nmar_0244	1.77e-61	198.0	COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota	651137|Thaumarchaeota	M	glycosyl transferase family	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
k59_206579_1	1236908.wNo_10890	1.97e-36	134.0	COG0666@1|root,COG0666@2|Bacteria,1NNGE@1224|Proteobacteria	1224|Proteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2
k59_68072_1	298654.FraEuI1c_1579	3.88e-52	174.0	28IJ3@1|root,2Z8K2@2|Bacteria,2H0MB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_68072_2	448385.sce2373	4.22e-34	128.0	COG2837@1|root,COG2837@2|Bacteria,1MXKF@1224|Proteobacteria,43801@68525|delta/epsilon subdivisions,2X39Y@28221|Deltaproteobacteria,2YV1P@29|Myxococcales	28221|Deltaproteobacteria	C	peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Dyp_perox
k59_57621_1	1229909.NSED_02395	8.94e-115	338.0	COG1131@1|root,arCOG00196@2157|Archaea,41S73@651137|Thaumarchaeota	651137|Thaumarchaeota	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k59_57621_2	1229909.NSED_02400	3.22e-12	64.7	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k59_305137_1	436308.Nmar_0538	1.76e-156	445.0	COG1085@1|root,arCOG00422@2157|Archaea,41S6T@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
k59_37925_1	436308.Nmar_1690	1.39e-189	535.0	COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
k59_285811_1	10224.XP_006825930.1	9.02e-28	116.0	KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria	33208|Metazoa	G	positive regulation of TOR signaling	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2,RVT_1
k59_105897_1	667121.ET1_24_00290	4.38e-54	176.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	stringent starvation protein A	sspA	GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N,GST_N_3
k59_105897_2	1260251.SPISAL_06895	3.79e-20	84.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1WYWV@135613|Chromatiales	135613|Chromatiales	S	Stringent starvation protein B	-	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
k59_276915_1	1177179.A11A3_11287	4.73e-11	62.8	COG4969@1|root,COG4969@2|Bacteria,1N94F@1224|Proteobacteria,1SD4U@1236|Gammaproteobacteria,1XM43@135619|Oceanospirillales	135619|Oceanospirillales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
k59_276915_2	342113.DM82_2049	1.49e-37	138.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,1K0ZU@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
k59_256619_1	33876.JNXY01000015_gene7375	1.88e-49	177.0	COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,4DET8@85008|Micromonosporales	201174|Actinobacteria	L	Integrase core domain	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	rve
k59_315705_2	1236908.wNo_05290	2.59e-19	85.9	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,47ETV@766|Rickettsiales	766|Rickettsiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
k59_57635_1	436308.Nmar_1114	3.52e-12	63.9	COG0299@1|root,arCOG02825@2157|Archaea,41SH3@651137|Thaumarchaeota	651137|Thaumarchaeota	F	phosphoribosylglycinamide formyltransferase	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
k59_57635_2	436308.Nmar_1113	2.34e-48	163.0	COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
k59_138036_1	570417.WP0944	1.11e-122	352.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,47FGN@766|Rickettsiales	766|Rickettsiales	O	May be required for disulfide bond formation in some proteins	dsbG	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
k59_116565_2	582744.Msip34_0158	1.05e-28	105.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VUY2@28216|Betaproteobacteria,2KP3R@206350|Nitrosomonadales	206350|Nitrosomonadales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
k59_88032_1	7029.ACYPI39717-PA	9.31e-54	198.0	KOG1075@1|root,KOG1075@2759|Eukaryota	7029.ACYPI39717-PA|-	E	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_235101_1	570417.WP1052	2.41e-88	272.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,47F2S@766|Rickettsiales	766|Rickettsiales	M	Belongs to the peptidase S1C family	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
k59_285829_1	43151.ADAC007967-PA	1.61e-86	290.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,429UH@6656|Arthropoda,3T0UB@50557|Insecta,458R2@7147|Diptera	33208|Metazoa	L	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1759,Peptidase_A17,rve
k59_156185_1	1150626.PHAMO_570049	5.2e-67	223.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0367 Asparagine synthase (glutamine-hydrolyzing)	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase,GATase_7
k59_285831_1	7070.TC009115-PA	5.76e-28	117.0	COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3BGB6@33208|Metazoa,3D5G4@33213|Bilateria,41ZUZ@6656|Arthropoda,3SKEY@50557|Insecta	33208|Metazoa	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,gag_pre-integrs,rve,zf-CCHC
k59_37961_1	1229909.NSED_07450	8.12e-72	231.0	COG0475@1|root,arCOG01956@2157|Archaea	2157|Archaea	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
k59_296751_1	1131266.ARWQ01000001_gene1117	2.28e-100	312.0	COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota	651137|Thaumarchaeota	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k59_126821_1	1266925.JHVX01000009_gene151	1.36e-61	211.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,372I1@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
k59_217649_1	27923.ML10424a-PA	5.47e-06	56.2	2E3ED@1|root,2SAHD@2759|Eukaryota,3A7DI@33154|Opisthokonta,3BT4U@33208|Metazoa	33208|Metazoa	S	Endonuclease-reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos_2
k59_127503_1	6087.XP_004207380.1	6.39e-06	54.7	COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa	6087.XP_004207380.1|-	OU	K02A2.6-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_235647_1	330214.NIDE4347	3.45e-86	267.0	COG0065@1|root,COG0065@2|Bacteria,3J0IH@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
k59_305620_1	163164.WD_0883	1.73e-95	281.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,47FH9@766|Rickettsiales	766|Rickettsiales	H	Pterin binding enzyme	folKP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK,Pterin_bind
k59_305620_2	100901.wOo_06870	2.58e-16	73.9	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,47GCV@766|Rickettsiales	766|Rickettsiales	H	Dihydrofolate reductase	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
k59_268172_1	570417.WP1169	8.54e-18	80.1	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,47EZ2@766|Rickettsiales	766|Rickettsiales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
k59_268172_2	1236908.wNo_08260	4.86e-62	190.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
k59_268172_3	1236908.wNo_08270	6.3e-17	74.3	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,47FJ9@766|Rickettsiales	766|Rickettsiales	J	its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
k59_188320_1	795666.MW7_3082	9.92e-45	158.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHND@28216|Betaproteobacteria,1K2B3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k59_316528_1	436308.Nmar_1548	5.59e-42	149.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
k59_316528_2	436308.Nmar_1549	4.47e-65	209.0	COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k59_38619_1	436308.Nmar_0299	1.02e-287	795.0	COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim,Transketolase_N
k59_68831_1	7213.XP_004534049.1	1.33e-46	172.0	COG2801@1|root,KOG0017@2759|Eukaryota,39TC6@33154|Opisthokonta,3BHT2@33208|Metazoa,3D2MB@33213|Bilateria,41VKT@6656|Arthropoda,3T0EP@50557|Insecta,4556W@7147|Diptera	33208|Metazoa	L	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_138929_1	331869.BAL199_15688	2.29e-19	87.4	COG0500@1|root,COG2226@2|Bacteria,1NIXW@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
k59_138929_2	1122236.KB905141_gene1334	1.73e-19	86.7	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG4627@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,COG4627@2|Bacteria,1RBR3@1224|Proteobacteria,2VSKQ@28216|Betaproteobacteria,2KP39@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
k59_127517_2	436308.Nmar_0333	9.34e-116	366.0	arCOG08778@1|root,arCOG08778@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_99218_1	436308.Nmar_0050	6.36e-117	345.0	COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
k59_277697_1	1095769.CAHF01000005_gene1585	7.07e-33	123.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2VX5D@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	vgb	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
k59_277697_2	1532557.JL37_11455	1.48e-27	111.0	COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VIG9@28216|Betaproteobacteria,3T72G@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	pgtC	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
k59_58419_1	1229909.NSED_05490	3.31e-146	436.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
k59_88905_1	7029.ACYPI004548-PA	2.26e-43	160.0	2CMP4@1|root,2QR56@2759|Eukaryota,39VQX@33154|Opisthokonta,3BR69@33208|Metazoa,3D755@33213|Bilateria,4230R@6656|Arthropoda,3T012@50557|Insecta	33208|Metazoa	S	Pao retrotransposon peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1758,DUF1759,Peptidase_A17,rve
k59_188346_1	570417.WP1114	3.15e-163	460.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,47FG8@766|Rickettsiales	766|Rickettsiales	P	Co Zn Cd efflux system component	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
k59_68855_1	1131266.ARWQ01000002_gene684	1.08e-85	278.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
k59_316556_1	443598.AUFA01000036_gene4811	1.62e-97	296.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
k59_48797_1	1229909.NSED_01720	7.32e-111	322.0	COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
k59_68861_1	748247.AZKH_4372	1.25e-31	127.0	COG3637@1|root,COG3637@2|Bacteria,1R42W@1224|Proteobacteria,2WHYH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
k59_68861_2	1454004.AW11_00400	6.75e-08	51.6	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1KR2U@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
k59_286431_1	864051.BurJ1DRAFT_2775	1.8e-90	277.0	COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2WEME@28216|Betaproteobacteria,1KN2F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
k59_188352_2	1161931.J7FAE2_9CAUD	9.64e-18	85.9	4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses  no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae	10662|Myoviridae	S	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_38648_1	15368.BRADI5G18616.1	1.6e-08	61.2	COG2801@1|root,KOG0017@2759|Eukaryota,37V5Q@33090|Viridiplantae,3GFFK@35493|Streptophyta,3M7B5@4447|Liliopsida,3IKJW@38820|Poales	35493|Streptophyta	L	transposition, RNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,Retrotran_gag_3,gag_pre-integrs,rve,zf-CCHC
k59_188358_1	436308.Nmar_0419	6.75e-84	254.0	COG1478@1|root,arCOG02714@2157|Archaea,41SHA@651137|Thaumarchaeota	651137|Thaumarchaeota	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
k59_147613_1	1236908.wNo_05660	3.57e-148	425.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,47EYN@766|Rickettsiales	766|Rickettsiales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k59_99263_1	1236908.wNo_07040	9.72e-82	249.0	COG0492@1|root,COG0492@2|Bacteria,1MW14@1224|Proteobacteria,2TSKU@28211|Alphaproteobacteria,47EYP@766|Rickettsiales	766|Rickettsiales	C	reductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
k59_99263_2	1236908.wNo_07030	4.59e-36	132.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,47EX9@766|Rickettsiales	766|Rickettsiales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	trmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
k59_138982_1	1229909.NSED_00720	1.61e-96	292.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k59_227694_2	1229909.NSED_09660	6.82e-95	283.0	COG2241@1|root,arCOG00650@2157|Archaea,41SGN@651137|Thaumarchaeota	651137|Thaumarchaeota	H	TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit	-	-	2.1.1.289	ko:K03399	ko00860,ko01100,map00860,map01100	-	R05813,R07775	RC00003,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	-	TP_methylase
k59_297601_1	1007105.PT7_1573	1.34e-137	397.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
k59_178941_1	7176.CPIJ015439-PA	0.0	1125.0	COG0507@1|root,KOG0987@2759|Eukaryota,39RYU@33154|Opisthokonta,3BK87@33208|Metazoa,3D4JP@33213|Bilateria,429W3@6656|Arthropoda,3SP5N@50557|Insecta,455R4@7147|Diptera,45DRP@7148|Nematocera	33208|Metazoa	L	Belongs to the helicase family	-	-	3.6.4.12	ko:K15255	-	-	-	-	ko00000,ko01000,ko03029,ko03032	-	-	-	Exo_endo_phos,Helitron_like_N,Herpes_Helicase,Herpes_teg_N,OTU,PIF1
k59_158034_1	1336235.JAEG01000016_gene4332	3.87e-08	60.8	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BCXZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,HemolysinCabind,LTD
k59_59729_1	15368.BRADI3G54376.1	1.35e-05	52.4	COG2801@1|root,KOG0017@2759|Eukaryota,37V5Q@33090|Viridiplantae,3GFFK@35493|Streptophyta	35493|Streptophyta	L	lipid metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF4219,RVT_2,Retrotran_gag_2,Retrotran_gag_3,gag_pre-integrs,rve,zf-CCHC
k59_258544_1	1123355.JHYO01000009_gene3130	9.23e-41	146.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2U2AJ@28211|Alphaproteobacteria,36YJZ@31993|Methylocystaceae	28211|Alphaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
k59_258550_1	1459636.NTE_02371	5.09e-106	324.0	COG0365@1|root,arCOG01529@2157|Archaea,41S8Z@651137|Thaumarchaeota	651137|Thaumarchaeota	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k59_118539_2	948106.AWZT01000103_gene3740	3.52e-47	152.0	2DP8X@1|root,33127@2|Bacteria,1ND0W@1224|Proteobacteria,2W78Y@28216|Betaproteobacteria,1KE3N@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_118539_3	671143.DAMO_2211	2.91e-06	48.9	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k59_228979_1	1217718.ALOU01000075_gene4522	1.07e-24	104.0	COG0834@1|root,COG0834@2|Bacteria,1NS23@1224|Proteobacteria,2W0B1@28216|Betaproteobacteria,1K5JJ@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	ABC transporter substrate-binding protein	-	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
k59_107608_1	1229909.NSED_05425	7.44e-82	246.0	COG3620@1|root,arCOG00608@2157|Archaea,41SJR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
k59_107608_2	1229909.NSED_05420	3.52e-20	90.1	COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Pyruvate phosphate dikinase	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
k59_128710_1	570417.WP0835	8.75e-280	765.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,47EUC@766|Rickettsiales	766|Rickettsiales	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k59_128710_2	570417.WP0834	2.66e-67	210.0	2CHCK@1|root,2ZA3K@2|Bacteria,1N36A@1224|Proteobacteria	1224|Proteobacteria	S	Bacterial EndoU nuclease	-	-	-	-	-	-	-	-	-	-	-	-	EndoU_bacteria
k59_148751_1	497321.C664_06543	1.86e-95	301.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KUM5@206389|Rhodocyclales	206389|Rhodocyclales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k59_59770_1	1131266.ARWQ01000003_gene1519	9.24e-109	322.0	COG0182@1|root,arCOG01123@2157|Archaea,41SF9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
k59_39888_1	436308.Nmar_1099	1.03e-95	289.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k59_199239_2	436308.Nmar_0961	4.38e-55	181.0	COG3276@1|root,arCOG01564@2157|Archaea,41SCR@651137|Thaumarchaeota	651137|Thaumarchaeota	J	elongation factor Tu	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
k59_118565_1	436308.Nmar_0242	1.13e-81	261.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
k59_148760_2	1417296.U879_08890	4.7e-12	65.5	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
k59_178991_1	680198.SCAB_60651	3.17e-34	125.0	2E1Q7@1|root,33JX9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_258604_1	1150469.RSPPHO_01401	2.23e-81	257.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
k59_77044_1	570417.WP1044	1.65e-127	362.0	arCOG06669@1|root,2ZC1E@2|Bacteria,1RBUZ@1224|Proteobacteria,2UIVS@28211|Alphaproteobacteria,47FQY@766|Rickettsiales	766|Rickettsiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k59_77044_2	1236908.wNo_07690	3.6e-60	198.0	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,47F4A@766|Rickettsiales	766|Rickettsiales	S	hmm tigr01630	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
k59_107651_1	1207075.PputUW4_03009	3.86e-47	162.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
## 3796 queries scanned
## Total time (seconds): 191.13701391220093
## Rate: 19.86 q/s