## Sat Jan 4 01:39:18 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA629394/SRR11734626/SRR11734626_p_cluster_rep_seq.fasta --output PRJNA629394_SRR11734626 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_49015_2 1229909.NSED_02415 5.97e-57 182.0 COG1392@1|root,arCOG02640@2157|Archaea,41SKJ@651137|Thaumarchaeota 651137|Thaumarchaeota P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_31253_1 7668.SPU_001651-tr 1.41e-174 550.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa 33208|Metazoa OU K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2 k59_46803_1 436308.Nmar_0086 5.98e-48 153.0 COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota 651137|Thaumarchaeota K snRNP Sm proteins - - - ko:K04796 - - - - ko00000 - - - LSM k59_46803_2 436308.Nmar_0085 1.61e-21 91.7 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_20159_1 1121937.AUHJ01000004_gene1013 4.96e-29 116.0 COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1T7KM@1236|Gammaproteobacteria,46C37@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM Integrase - - - - - - - - - - - - - k59_37935_1 1131266.ARWQ01000010_gene41 1.29e-63 198.0 COG0197@1|root,arCOG04113@2157|Archaea,41SKN@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02866 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_13501_1 1229909.NSED_09120 2e-05 45.4 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_13501_2 436308.Nmar_1714 2.69e-174 493.0 COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota 651137|Thaumarchaeota M FtsX-like permease family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_6791_1 1123228.AUIH01000001_gene1300 8.32e-73 237.0 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,1RRWV@1236|Gammaproteobacteria,1XIQA@135619|Oceanospirillales 135619|Oceanospirillales CH Phenol hydroxylase, C-terminal dimerisation domain - - 1.14.13.7 ko:K03380 ko00623,ko00627,ko01120,map00623,map00627,map01120 - R00815,R03566 RC00046,RC00236 ko00000,ko00001,ko01000 - - - FAD_binding_3,Phe_hydrox_dim k59_42316_1 522306.CAP2UW1_4142 2.82e-103 311.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,1KPT4@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I acetyl-CoA carboxylase, biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_2372_1 266264.Rmet_1160 5.28e-111 338.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,1JZSF@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_51209_1 1229909.NSED_00170 3.13e-23 97.1 COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota 651137|Thaumarchaeota M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - - - - - - - - - - - k59_60115_1 1229909.NSED_00395 9.22e-50 170.0 COG0843@1|root,arCOG01237@2157|Archaea,41S9Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Heme copper-type cytochrome quinol - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_60115_2 436308.Nmar_0185 2.62e-50 168.0 COG3794@1|root,arCOG03700@1|root,arCOG02926@2157|Archaea,arCOG03700@2157|Archaea 2157|Archaea C Blue copper protein - - - - - - - - - - - - Copper-bind k59_60119_1 391735.Veis_4886 1.11e-57 191.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4AAP5@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_35741_1 1299327.I546_0424 1.63e-10 57.8 COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,23ANF@1762|Mycobacteriaceae 201174|Actinobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_35741_2 159749.E7BWN7 6.18e-65 199.0 COG0099@1|root,KOG3311@2759|Eukaryota 2759|Eukaryota J rRNA binding rps13 GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0031967,GO:0031974,GO:0031975,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0071840,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904 2.7.7.6 ko:K02952,ko:K03040 ko00230,ko00240,ko01100,ko03010,ko03020,map00230,map00240,map01100,map03010,map03020 M00178,M00179,M00183 R00435,R00441,R00442,R00443 RC02795 br01610,br01611,ko00000,ko00001,ko00002,ko01000,ko03011,ko03021,ko03400 - - - Ribosomal_S13 k59_35741_3 159749.E7BWN8 1.17e-33 119.0 COG0100@1|root,KOG0408@2759|Eukaryota 2759|Eukaryota J rRNA binding rps11 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - Ribosomal_S11,Ribosomal_S13 k59_62366_1 548477.HMPREF0294_0332 4.97e-05 52.0 COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae 2|Bacteria M chlorophyll binding - - - - - - - - - - - - Collagen,G5,TSP_3,YSIRK_signal k59_22407_1 436308.Nmar_1025 4.28e-70 213.0 COG0537@1|root,arCOG00419@2157|Archaea,41SNI@651137|Thaumarchaeota 651137|Thaumarchaeota F HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_22407_2 1229909.NSED_06030 5.83e-14 69.3 COG0484@1|root,COG1141@1|root,arCOG00349@2157|Archaea,arCOG02846@2157|Archaea,41ST0@651137|Thaumarchaeota 651137|Thaumarchaeota CO DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - - - - - - - - - - DnaJ,Fer4_13 k59_55672_1 187272.Mlg_0269 2.23e-121 373.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_46868_1 1229909.NSED_04505 1.68e-127 372.0 COG2133@1|root,arCOG02796@2157|Archaea,41T0Q@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH k59_159_1 1123368.AUIS01000008_gene2233 1.84e-31 125.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,2ND99@225057|Acidithiobacillales 225057|Acidithiobacillales Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_42372_1 1266925.JHVX01000010_gene1333 5.52e-70 220.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,372XM@32003|Nitrosomonadales 28216|Betaproteobacteria I Squalene/phytoene synthase hpnD - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_69088_1 1288494.EBAPG3_24940 1.3e-92 283.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,372HP@32003|Nitrosomonadales 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_60169_1 436308.Nmar_1547 3.61e-106 342.0 arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_49054_1 436308.Nmar_1628 1.72e-185 535.0 COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD k59_49061_1 203122.Sde_3194 1e-19 89.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,465AG@72275|Alteromonadaceae 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_49061_2 335283.Neut_1593 8.67e-31 111.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,373HB@32003|Nitrosomonadales 28216|Betaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_37988_1 1049564.TevJSym_ac01310 5.49e-08 54.7 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_37988_2 265072.Mfla_2093 2.13e-16 81.6 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KMAI@206350|Nitrosomonadales 206350|Nitrosomonadales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_20218_1 436308.Nmar_1119 8.17e-114 337.0 COG0151@1|root,arCOG04415@2157|Archaea,41SB3@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_26891_1 436308.Nmar_0347 4.23e-140 426.0 COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_26895_1 1097668.BYI23_A024010 2.08e-88 272.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1K15K@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_20237_1 395495.Lcho_2150 6.88e-101 303.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,1KK3S@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_66905_1 1229909.NSED_09745 3.24e-90 278.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_15720_1 436308.Nmar_1066 2.5e-88 270.0 COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - - - - - - - - - - tRNA-synt_2,tRNA_anti-codon k59_15720_2 1229909.NSED_06220 2.11e-16 74.3 COG0195@1|root,arCOG01761@2157|Archaea,41T4Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription elongation factor - - - - - - - - - - - - - k59_22434_1 436308.Nmar_1544 4.16e-86 257.0 COG0723@1|root,arCOG01720@2157|Archaea,41SCE@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Rieske 2Fe-2S domain - - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,TAT_signal k59_62418_1 519989.ECTPHS_02961 9.28e-57 189.0 COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,1S1D4@1236|Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_64638_1 436308.Nmar_1267 5.77e-160 471.0 COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota 651137|Thaumarchaeota E Methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind k59_26921_2 448385.sce1900 2.19e-15 75.5 COG2963@1|root,COG2963@2|Bacteria,1QVMA@1224|Proteobacteria,42U44@68525|delta/epsilon subdivisions,2WQ61@28221|Deltaproteobacteria,2Z1QI@29|Myxococcales 28221|Deltaproteobacteria L High confidence in function and specificity - - - - - - - - - - - - HTH_Tnp_1 k59_53501_1 292415.Tbd_0963 3.98e-80 247.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1KRKH@119069|Hydrogenophilales 119069|Hydrogenophilales GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_64651_1 7668.SPU_022563-tr 1.24e-50 189.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39VXI@33154|Opisthokonta,3BY4F@33208|Metazoa,3DDBT@33213|Bilateria 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_55741_1 1565129.JSFF01000015_gene19 3.22e-16 82.8 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,2QB0C@267890|Shewanellaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_57995_1 436308.Nmar_1398 2.18e-100 311.0 COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota 651137|Thaumarchaeota L AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_24690_1 1411123.JQNH01000001_gene2713 2.74e-67 223.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DUF3394,DctM k59_66940_1 477184.KYC_09095 4.4e-97 296.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,3T1PC@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the transfer of electrons from NADH to quinone nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_2497_1 1229909.NSED_01660 9.39e-31 118.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_18059_1 1158182.KB905021_gene671 5.02e-17 78.2 COG4520@1|root,COG4520@2|Bacteria,1RIHU@1224|Proteobacteria 1224|Proteobacteria M Glycine zipper - - - - - - - - - - - - 17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti k59_55769_1 1304883.KI912532_gene1582 3.85e-140 423.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_42468_1 7091.BGIBMGA006564-TA 8.53e-50 167.0 2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - - k59_69198_1 1122201.AUAZ01000046_gene2159 6.35e-32 124.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,1RZG1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_46933_1 1229909.NSED_06010 3.11e-106 313.0 arCOG08737@1|root,arCOG08737@2157|Archaea,41T1W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_262_1 1121033.AUCF01000039_gene438 1.39e-07 50.1 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2U9JC@28211|Alphaproteobacteria,2JZSW@204441|Rhodospirillales 204441|Rhodospirillales S Sulphur oxidation protein SoxZ - - - - - - - - - - - - SoxZ k59_262_2 204773.HEAR1193 2.2e-42 148.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,475V5@75682|Oxalobacteraceae 28216|Betaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA soxA - - ko:K17222 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - - k59_44748_1 1229909.NSED_01590 5.26e-114 338.0 COG0428@1|root,arCOG00576@2157|Archaea,41S6R@651137|Thaumarchaeota 651137|Thaumarchaeota P divalent heavy-metal cations transporter - - - - - - - - - - - - - k59_281_1 257313.BP1777 2.26e-05 47.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,3T2D6@506|Alcaligenaceae 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_49176_1 1101189.AQUO01000001_gene3284 9.31e-20 88.2 COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria,2PVIX@265|Paracoccus 28211|Alphaproteobacteria S Tetratricopeptide repeats MA20_05980 - - - - - - - - - - - TPR_16,TPR_2,TPR_6,TPR_8 k59_49176_2 748247.AZKH_p0450 8.91e-60 191.0 COG0705@1|root,COG0705@2|Bacteria,1RJYI@1224|Proteobacteria,2W1AJ@28216|Betaproteobacteria,2KXTX@206389|Rhodocyclales 206389|Rhodocyclales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_55797_1 9823.ENSSSCP00000019138 1.62e-25 101.0 COG1622@1|root,KOG4767@2759|Eukaryota,38FF8@33154|Opisthokonta,3BEBX@33208|Metazoa,3D20G@33213|Bilateria,48627@7711|Chordata,4991G@7742|Vertebrata,3JCNC@40674|Mammalia,4J74R@91561|Cetartiodactyla 33208|Metazoa C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 COX2 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006140,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006979,GO:0007275,GO:0007589,GO:0007595,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010310,GO:0010562,GO:0010726,GO:0010728,GO:0010729,GO:0010939,GO:0010940,GO:0010941,GO:0010942,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0017144,GO:0019219,GO:0019220,GO:0019222,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0030808,GO:0030810,GO:0030879,GO:0031090,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0045935,GO:0045937,GO:0045981,GO:0046034,GO:0046483,GO:0046903,GO:0048513,GO:0048518,GO:0048522,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050794,GO:0050878,GO:0050896,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051194,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0080090,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1900371,GO:1900373,GO:1900542,GO:1900544,GO:1901135,GO:1901360,GO:1901564,GO:1902600,GO:1903426,GO:1903428,GO:1903578,GO:1903580,GO:2000377,GO:2000379,GO:2001169,GO:2001171 - ko:K02261 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX2,COX2_TM k59_18080_1 261292.Nit79A3_3535 1.47e-39 142.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,37205@32003|Nitrosomonadales 28216|Betaproteobacteria D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_18080_2 267608.RSc2844 1.05e-56 188.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,1JZPA@119060|Burkholderiaceae 28216|Betaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_6916_1 436308.Nmar_0075 3.73e-65 218.0 COG1287@1|root,arCOG02044@2157|Archaea,41SBI@651137|Thaumarchaeota 651137|Thaumarchaeota G Oligosaccharyl transferase STT3 subunit - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_53572_1 357276.EL88_08490 5.1e-19 92.8 COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,2FPNU@200643|Bacteroidia,4AMB2@815|Bacteroidaceae 976|Bacteroidetes L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_40287_1 1229909.NSED_01635 8.22e-95 283.0 COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota 651137|Thaumarchaeota S tRNA methyl transferase - - - ko:K06864 - - - - ko00000 - - - QueC k59_42241_1 1229909.NSED_03240 7.58e-171 508.0 arCOG08752@1|root,arCOG08752@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_46711_1 1002672.SAR11G3_00190 2.26e-96 294.0 COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VF0S@28211|Alphaproteobacteria,4BTD5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_6 k59_20078_1 631454.N177_3820 1.42e-42 152.0 COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,1JQCV@119043|Rhodobiaceae 28211|Alphaproteobacteria S LVIVD repeat - - - - - - - - - - - - LVIVD k59_20078_2 196367.JNFG01000031_gene8767 7.37e-22 94.7 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K1NF@119060|Burkholderiaceae 28216|Betaproteobacteria C aconitate hydratase - - - - - - - - - - - - Aconitase,Aconitase_C k59_24515_1 1229909.NSED_09690 1.07e-78 254.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_35632_2 10224.XP_006822946.1 4.86e-26 103.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta 33154|Opisthokonta IQ Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_60043_2 1229909.NSED_09480 2.96e-28 111.0 COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota 2157|Archaea P Sodium hydrogen exchanger napA - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_17865_1 1454004.AW11_02082 8.7e-86 265.0 COG0738@1|root,COG0738@2|Bacteria,1P1TX@1224|Proteobacteria 1224|Proteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_20090_1 1229909.NSED_01675 1.58e-117 369.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_64492_1 1301098.PKB_1200 2.76e-38 145.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria 1236|Gammaproteobacteria N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux k59_22305_1 1968.JOEV01000032_gene8127 5.62e-21 92.8 COG1802@1|root,COG1802@2|Bacteria,2I8SM@201174|Actinobacteria 201174|Actinobacteria K gntR family - - - - - - - - - - - - FCD,GntR k59_57864_1 436308.Nmar_1562 1e-66 214.0 COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota 651137|Thaumarchaeota J ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA tiaS - 6.3.4.22 ko:K06932 - - - - ko00000,ko01000,ko03016 - - - DUF1743 k59_48964_1 436308.Nmar_0684 2.31e-107 319.0 COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota 651137|Thaumarchaeota S small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_6743_1 196367.JNFG01000214_gene1294 2.13e-36 134.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_28965_1 7668.SPU_000868-tr 2.57e-43 166.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39NE5@33154|Opisthokonta,3CPYS@33208|Metazoa,3E63Y@33213|Bilateria 2759|Eukaryota S Endonuclease-reverse transcriptase - - - - - - - - - - - - RVT_1 k59_28982_1 472759.Nhal_0511 2.54e-102 303.0 COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,1RYSQ@1236|Gammaproteobacteria,1X2G9@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_51173_1 1229909.NSED_09845 2.04e-115 336.0 COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_51183_1 436308.Nmar_1489 3.55e-135 393.0 COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota 651137|Thaumarchaeota J Phenylalanyl-tRNA synthetase alpha subunit - - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d k59_49007_1 1144319.PMI16_03169 1.25e-54 182.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VZEM@28216|Betaproteobacteria,478Q9@75682|Oxalobacteraceae 28216|Betaproteobacteria Q taurine catabolism dioxygenase tauD - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_33434_1 795666.MW7_3243 9.56e-85 259.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,1K25Z@119060|Burkholderiaceae 28216|Betaproteobacteria P Phosphate transporter pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_26791_1 98439.AJLL01000012_gene2103 4.62e-71 236.0 COG0542@1|root,COG0542@2|Bacteria,1G0ZH@1117|Cyanobacteria,1JHJY@1189|Stigonemataceae 1117|Cyanobacteria O C-terminal, D2-small domain, of ClpB protein clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_44585_1 436308.Nmar_1055 9.85e-94 286.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_44585_2 1229909.NSED_06190 1.88e-46 154.0 COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota 651137|Thaumarchaeota L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_53428_1 1458427.BAWN01000012_gene706 1.61e-84 262.0 COG3580@1|root,COG3580@2|Bacteria 2|Bacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_11208_1 765912.Thimo_0459 1.15e-121 361.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales 135613|Chromatiales L reverse transcriptase - - - - - - - - - - - - RVT_1 k59_29017_1 10224.XP_002739487.1 8.69e-56 202.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BPSU@33208|Metazoa,3E41R@33213|Bilateria 33208|Metazoa IQ Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_31234_1 1437425.CSEC_1670 0.00099 41.2 COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2JFH9@204428|Chlamydiae 204428|Chlamydiae CJ CoA binding domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_31234_2 1280947.HY30_15925 0.000875 46.6 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1042 Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_31244_1 1144319.PMI16_02480 6.41e-78 251.0 COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria 1224|Proteobacteria E amino acid - - - - - - - - - - - - AA_permease_2 k59_49015_1 1229909.NSED_02420 1.88e-109 322.0 COG0306@1|root,arCOG02267@2157|Archaea,41SD8@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate transporter family - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_29483_1 365046.Rta_26250 6.71e-63 208.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VH96@28216|Betaproteobacteria,4AAEM@80864|Comamonadaceae 28216|Betaproteobacteria Q copper-resistance protein, CopA family copA - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_62912_1 880071.Fleli_0367 1.33e-16 83.2 COG0861@1|root,COG0861@2|Bacteria,4NH7P@976|Bacteroidetes,47N45@768503|Cytophagia 976|Bacteroidetes P PFAM Integral membrane protein TerC ygjT - - ko:K05794 - - - - ko00000 - - - TerC k59_3001_1 504832.OCAR_7525 9.28e-114 333.0 COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2TRX5@28211|Alphaproteobacteria,3JRYA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_5080_1 436308.Nmar_0209 1.59e-50 169.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_11727_1 1229909.NSED_09015 5.36e-97 304.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_31840_1 335283.Neut_2022 4.24e-65 222.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,3729D@32003|Nitrosomonadales 28216|Betaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_29497_1 436308.Nmar_1731 6.05e-54 179.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_29497_2 436308.Nmar_1730 6.39e-67 208.0 COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota 651137|Thaumarchaeota O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_20680_1 1446473.JHWH01000031_gene3521 1.76e-11 64.3 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2PUN7@265|Paracoccus 28211|Alphaproteobacteria E TOBE domain MA20_04260 - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 k59_20680_2 1089551.KE386572_gene2549 5e-13 71.6 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type Fe3 transport system permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_58514_1 1229909.NSED_00030 2.29e-97 308.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_16236_1 42565.FP66_00805 4.36e-48 167.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria 1236|Gammaproteobacteria G TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_16236_2 1123366.TH3_06360 7.08e-30 118.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JQI2@204441|Rhodospirillales 204441|Rhodospirillales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_3024_1 1267535.KB906767_gene4791 1.16e-06 54.7 COG1413@1|root,COG1413@2|Bacteria,3Y7N7@57723|Acidobacteria 57723|Acidobacteria C Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_14121_1 265072.Mfla_2497 1.67e-67 217.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,2KM20@206350|Nitrosomonadales 206350|Nitrosomonadales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_22921_1 1051501.AYTL01000030_gene2988 3.66e-37 133.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,1ZBGS@1386|Bacillus 91061|Bacilli T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_58533_1 7668.SPU_028323-tr 2.92e-60 192.0 2BG5J@1|root,2S18N@2759|Eukaryota,3A435@33154|Opisthokonta,3BRGG@33208|Metazoa,3D8KM@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_36288_1 502025.Hoch_1127 6.27e-66 214.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_29516_1 864051.BurJ1DRAFT_0491 1.12e-112 344.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,1KJI7@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_22930_1 269482.Bcep1808_1152 2e-40 143.0 COG0270@1|root,COG0270@2|Bacteria,1N0XD@1224|Proteobacteria 1224|Proteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_5117_1 1429851.X548_05315 2.21e-89 268.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1X340@135614|Xanthomonadales 135614|Xanthomonadales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_58538_1 436308.Nmar_1700 5.69e-81 251.0 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_65133_1 580332.Slit_2096 5.77e-38 146.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,44V1N@713636|Nitrosomonadales 28216|Betaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_20705_1 479434.Sthe_1398 9.75e-59 186.0 COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,27XMB@189775|Thermomicrobia 189775|Thermomicrobia C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_69632_1 436308.Nmar_0199 4.96e-21 84.0 arCOG10519@1|root,arCOG10519@2157|Archaea,41T6D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_69632_2 436308.Nmar_0200 9.97e-77 231.0 arCOG08634@1|root,arCOG08634@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_69632_3 436308.Nmar_0201 1.25e-34 125.0 COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_56270_1 436308.Nmar_0319 6.61e-49 160.0 COG2178@1|root,arCOG04318@2157|Archaea,41SKR@651137|Thaumarchaeota 651137|Thaumarchaeota J Translin family - - - ko:K07477 - - - - ko00000 - - - Translin k59_17598_1 1123399.AQVE01000020_gene1700 2.33e-46 167.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,45ZUC@72273|Thiotrichales 72273|Thiotrichales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_17598_2 948106.AWZT01000009_gene2883 7.14e-22 94.4 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,1JZXX@119060|Burkholderiaceae 28216|Betaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_26406_1 1229909.NSED_02580 2.79e-78 241.0 COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_26406_2 436308.Nmar_0513 1.49e-16 73.6 arCOG10528@1|root,arCOG10528@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_48559_1 8090.ENSORLP00000002242 8.79e-166 503.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39MT6@33154|Opisthokonta,3BKSP@33208|Metazoa,3E5HK@33213|Bilateria,48J71@7711|Chordata,49FH1@7742|Vertebrata,4A6VG@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_53134_1 1229909.NSED_08230 1.53e-64 207.0 arCOG08642@1|root,arCOG08642@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_53134_2 436308.Nmar_1494 2.75e-25 97.8 COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.3 ko:K02201 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_39867_1 1229909.NSED_07150 3.2e-126 363.0 COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_62098_1 313612.L8106_00300 1.04e-57 199.0 COG2931@1|root,COG2931@2|Bacteria,1G1JS@1117|Cyanobacteria,1H9YK@1150|Oscillatoriales 1117|Cyanobacteria C Animal haem peroxidase - - 1.11.1.7 ko:K19511 - - - - ko00000,ko01000 - - - An_peroxidase,HemolysinCabind k59_55316_1 1229909.NSED_09335 1.24e-102 310.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_6451_1 935845.JADQ01000041_gene2223 9.73e-12 70.5 COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli,26TE8@186822|Paenibacillaceae 91061|Bacilli H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate and vanillate yclC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 4.1.1.61 ko:K01612,ko:K16874 ko00365,ko00627,ko01120,ko01220,map00365,map00627,map01120,map01220 - R01238,R10213 RC00391,RC03086 ko00000,ko00001,ko01000 - - - UbiD k59_10978_1 1122244.AUGF01000070_gene944 1.07e-06 45.4 2DR8E@1|root,33ANS@2|Bacteria,1NI69@1224|Proteobacteria,1SH0M@1236|Gammaproteobacteria,3NQGT@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_55321_1 502025.Hoch_4977 1.38e-05 54.3 COG1061@1|root,COG1061@2|Bacteria,1PPY3@1224|Proteobacteria,43AP9@68525|delta/epsilon subdivisions 1224|Proteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - ERCC3_RAD25_C,Helicase_C,PLDc_2,ResIII k59_17628_2 107636.JQNK01000009_gene1975 2.06e-20 84.3 2AKUS@1|root,31BMX@2|Bacteria,1NZDG@1224|Proteobacteria,2UTNA@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_50817_1 279303.Q6J7X1_9CAUD 1.05e-85 267.0 4QCM9@10239|Viruses,4QVZV@35237|dsDNA viruses no RNA stage,4QTYN@28883|Caudovirales,4QMZ7@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_48603_2 1229909.NSED_02140 2.23e-104 309.0 COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota 651137|Thaumarchaeota C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_39898_1 1348662.CARG_05570 1.64e-24 100.0 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,22JKK@1653|Corynebacteriaceae 201174|Actinobacteria GK polyphosphate glucokinase ppgK GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0040007,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0047330,GO:0051156,GO:0071704,GO:1901135 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_39898_2 1120959.ATXF01000006_gene1970 2.74e-11 63.9 COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4FP70@85023|Microbacteriaceae 201174|Actinobacteria C NifU-like N terminal domain iscU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_15543_1 1454004.AW11_03084 7.4e-81 249.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria 28216|Betaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_26412_1 436308.Nmar_0428 9.72e-61 193.0 COG0202@1|root,arCOG04241@2157|Archaea,41SK0@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-directed RNA polymerase, alpha subunit 40 kD subunit - - 2.7.7.6 ko:K03047 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_A_bac,RNA_pol_L k59_50820_1 887898.HMPREF0551_1719 1.73e-97 301.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,1K36E@119060|Burkholderiaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_50827_1 977880.RALTA_A3092 6.92e-115 341.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1K2Y1@119060|Burkholderiaceae 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_13104_2 977880.RALTA_A1854 5.53e-56 184.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,1K1RS@119060|Burkholderiaceae 28216|Betaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_10996_1 436308.Nmar_0430 9.77e-81 244.0 COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota 651137|Thaumarchaeota J Shwachman-Bodian-Diamond syndrome (SBDS) protein - - - ko:K14574 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - SBDS,SBDS_C k59_10996_2 1229909.NSED_02240 4.99e-34 122.0 COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome rrp4 - - ko:K03679 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - KH_1 k59_62152_1 1229909.NSED_03170 1.95e-102 327.0 arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota 651137|Thaumarchaeota L Lamin Tail Domain - - - - - - - - - - - - LTD k59_17681_1 1229909.NSED_09200 1.46e-65 204.0 COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_17681_2 436308.Nmar_1729 1.67e-06 49.3 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_57736_1 153721.MYP_3456 1.06e-13 75.9 COG5659@1|root,COG5659@2|Bacteria,4NQCF@976|Bacteroidetes,47UV4@768503|Cytophagia 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_40758_1 1354722.JQLS01000005_gene3850 1.94e-75 238.0 COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TVPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_60713_1 6087.XP_002161315.2 2.35e-34 134.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3AMIH@33154|Opisthokonta,3C0YK@33208|Metazoa 2759|Eukaryota S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1,zf-CCHC k59_18590_1 1266925.JHVX01000007_gene2359 1.9e-114 340.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria,372JZ@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Aminotransferase, class V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_36334_1 279303.Q6J827_9CAUD 1.18e-244 690.0 4QBSP@10239|Viruses,4QZ8J@35237|dsDNA viruses no RNA stage,4QRAT@28883|Caudovirales,4QM0N@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_36334_3 279303.Q6J825_9CAUD 5.31e-123 358.0 4QC5Z@10239|Viruses,4QUNP@35237|dsDNA viruses no RNA stage,4QPGX@28883|Caudovirales,4QKMB@10699|Siphoviridae 10699|Siphoviridae S Phage Mu protein F like protein - GO:0005575,GO:0019012,GO:0019028,GO:0044423,GO:0046729 - - - - - - - - - - - k59_36334_5 279303.Q6J824_9CAUD 1.05e-71 230.0 4QF1F@10239|Viruses,4QZU3@35237|dsDNA viruses no RNA stage,4QSH1@28883|Caudovirales,4QKX4@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_3112_1 436308.Nmar_1179 5.48e-95 288.0 arCOG08686@1|root,arCOG08686@2157|Archaea,41T56@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_65209_1 1229909.NSED_00275 5e-114 340.0 COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota 651137|Thaumarchaeota S Radical SAM - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_11836_1 7668.SPU_006771-tr 3.52e-68 231.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria 33208|Metazoa G positive regulation of TOR signaling - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_36340_1 244447.XP_008333619.1 4.62e-51 185.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_65226_1 543632.JOJL01000014_gene9183 2.15e-22 98.6 COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4D9Y8@85008|Micromonosporales 201174|Actinobacteria G phosphoglycerate mutase - - 3.1.3.85 ko:K22306 - - - - ko00000,ko01000 - - - His_Phos_1 k59_5172_1 1502724.FF80_03107 5.01e-34 127.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_63041_1 1128427.KB904821_gene4032 5.4e-18 85.5 COG0642@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,1H8X5@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 k59_5185_1 349521.HCH_04640 5.95e-36 131.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1XRB8@135619|Oceanospirillales 135619|Oceanospirillales T helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_63051_1 1229909.NSED_07125 1.89e-61 194.0 COG1116@1|root,arCOG00193@2157|Archaea,41S6Q@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_63051_2 436308.Nmar_1283 2.34e-48 160.0 COG0600@1|root,arCOG00169@2157|Archaea,41SIT@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_45240_1 7668.SPU_022296-tr 2.93e-84 283.0 COG5059@1|root,KOG1075@1|root,KOG0242@2759|Eukaryota,KOG1075@2759|Eukaryota,38GPV@33154|Opisthokonta,3BF94@33208|Metazoa,3CWIA@33213|Bilateria 33208|Metazoa Z microtubule motor activity KIF22 GO:0000070,GO:0000278,GO:0000280,GO:0000775,GO:0000776,GO:0000785,GO:0000819,GO:0000902,GO:0000904,GO:0001654,GO:0001756,GO:0001966,GO:0002376,GO:0002478,GO:0002495,GO:0002504,GO:0003002,GO:0003674,GO:0003676,GO:0003677,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0005871,GO:0005875,GO:0006810,GO:0006890,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007049,GO:0007059,GO:0007062,GO:0007080,GO:0007275,GO:0007389,GO:0007399,GO:0007409,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009605,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009952,GO:0009987,GO:0015630,GO:0016043,GO:0016192,GO:0016462,GO:0016604,GO:0016607,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019882,GO:0019884,GO:0019886,GO:0021952,GO:0021953,GO:0021954,GO:0021955,GO:0022008,GO:0022402,GO:0030030,GO:0030154,GO:0030182,GO:0031175,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0032991,GO:0035282,GO:0040011,GO:0042330,GO:0043009,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0048002,GO:0048193,GO:0048285,GO:0048468,GO:0048513,GO:0048592,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050000,GO:0050896,GO:0051179,GO:0051234,GO:0051276,GO:0051303,GO:0051310,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0060322,GO:0060429,GO:0061053,GO:0061564,GO:0070013,GO:0071840,GO:0072686,GO:0090596,GO:0097159,GO:0098687,GO:0098813,GO:0120036,GO:0120039,GO:0140014,GO:1901363,GO:1903047 - ko:K02988,ko:K10403 ko03010,ko04914,map03010,map04914 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko04812 - - - HHH_3,Kinesin k59_7491_1 1123393.KB891332_gene2739 3.96e-34 135.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,1KSMG@119069|Hydrogenophilales 119069|Hydrogenophilales L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_31957_1 243365.CV_0001 1.95e-18 90.1 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KPIA@206351|Neisseriales 206351|Neisseriales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_14212_1 436308.Nmar_1497 4.8e-54 180.0 arCOG03932@1|root,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota 651137|Thaumarchaeota K Cobalamin B12-binding domain protein - - - - - - - - - - - - - k59_9663_1 436308.Nmar_0921 8.68e-156 442.0 COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota 651137|Thaumarchaeota HK Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_58642_1 7897.ENSLACP00000023632 1.02e-42 154.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3C0YC@33208|Metazoa,3DH14@33213|Bilateria,48RUJ@7711|Chordata,49N81@7742|Vertebrata 33208|Metazoa S RNA-directed DNA polymerase from mobile element jockey-like - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_67554_1 1229909.NSED_08260 7.22e-59 184.0 arCOG10586@1|root,arCOG10586@2157|Archaea,41STH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_67554_2 436308.Nmar_1500 6.94e-43 144.0 arCOG08676@1|root,arCOG08676@2157|Archaea,41SCF@651137|Thaumarchaeota 651137|Thaumarchaeota C Archaeal ammonia monooxygenase subunit A (AmoA) - - 1.14.18.3,1.14.99.39 ko:K10944 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Archaeal_AmoA k59_11864_1 1286093.C266_21829 8.9e-96 301.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,1K10Y@119060|Burkholderiaceae 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_49692_1 436308.Nmar_0543 1.03e-111 332.0 COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein ThiC - - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_14214_1 10685.PORTL_BPSP1 6.05e-08 56.6 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage 10239|Viruses S Phage portal protein - - - - - - - - - - - - - k59_23195_1 1229909.NSED_09205 5.25e-104 309.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_65420_1 330214.NIDE2123 3.33e-130 377.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_29,rve,rve_3 k59_63230_2 279303.Q6J801_9CAUD 1.46e-40 143.0 4QEE8@10239|Viruses,4QY3Y@35237|dsDNA viruses no RNA stage,4QT86@28883|Caudovirales,4QMS7@10699|Siphoviridae 10699|Siphoviridae S Pfam:DUF5047 - - - - - - - - - - - - - k59_5373_1 502025.Hoch_1127 2.87e-142 416.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_47529_1 62928.azo1278 3.92e-53 188.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVC7@206389|Rhodocyclales 206389|Rhodocyclales T PAC sensor-containing diguanylate cyclase phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS,PAS_9 k59_56533_1 1121374.KB891588_gene3351 1.12e-74 230.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,1S2G5@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Acetyltransferases including N-acetylases of ribosomal proteins ydaF_1 - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 k59_56535_1 1229909.NSED_09050 1.37e-49 167.0 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_56535_2 1229909.NSED_09055 2.73e-17 75.5 arCOG10411@1|root,arCOG10411@2157|Archaea,41T7X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_32150_1 1229909.NSED_07280 2.84e-76 233.0 COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota 651137|Thaumarchaeota O Proteasome endopeptidase complex - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome,Proteasome_A_N k59_32150_2 1229909.NSED_07285 4.14e-22 90.9 COG2226@1|root,arCOG04348@2157|Archaea,41SGQ@651137|Thaumarchaeota 651137|Thaumarchaeota Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_69949_1 622637.KE124773_gene4159 1.28e-39 134.0 COG3293@1|root,COG3293@2|Bacteria,1QXE6@1224|Proteobacteria,2TX8K@28211|Alphaproteobacteria,371IP@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_69949_2 251221.35212193 8.21e-62 192.0 COG3293@1|root,COG3293@2|Bacteria,1G7GI@1117|Cyanobacteria 1117|Cyanobacteria L similarity to GB CAD86359.1 - - - - - - - - - - - - DUF4096 k59_45411_1 1229909.NSED_05260 2.38e-63 199.0 arCOG02416@1|root,arCOG02416@2157|Archaea 2157|Archaea S Archaeal Type IV pilin, N-terminal - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PKD,Pilin_N k59_12028_1 1121861.KB899913_gene2241 6.81e-25 105.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 k59_41007_2 31234.CRE13126 1.85e-45 166.0 KOG4740@1|root,KOG4740@2759|Eukaryota,3A4S6@33154|Opisthokonta,3BUQE@33208|Metazoa,3E551@33213|Bilateria,40FH4@6231|Nematoda,1KYF2@119089|Chromadorea,414KC@6236|Rhabditida 33208|Metazoa S proton channel activity - - - - - - - - - - - - DDE_3,PAX k59_52034_1 331869.BAL199_16928 2.42e-138 400.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_52034_2 1041146.ATZB01000075_gene406 8.82e-37 129.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,4BCFB@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_56550_1 999541.bgla_2g19270 1.82e-61 198.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VIDM@28216|Betaproteobacteria,1K42J@119060|Burkholderiaceae 28216|Betaproteobacteria S Amidohydrolase - - 3.1.1.57 ko:K10221 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R04277 RC03110 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_14445_1 760117.JN27_16920 3.29e-108 318.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,4735F@75682|Oxalobacteraceae 28216|Betaproteobacteria J Glycyl-tRNA synthetase, alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_43247_1 1192034.CAP_2270 6.31e-15 80.1 COG3204@1|root,COG3204@2|Bacteria,1QXTC@1224|Proteobacteria,43C5S@68525|delta/epsilon subdivisions,2X7G0@28221|Deltaproteobacteria,2YZ2J@29|Myxococcales 28221|Deltaproteobacteria L pilus organization - - - - - - - - - - - - - k59_58853_1 1229909.NSED_01430 3.99e-80 252.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_49832_1 553178.CAPGI0001_0530 9.81e-20 99.0 COG5410@1|root,COG5410@2|Bacteria,4NN30@976|Bacteroidetes,1ICKB@117743|Flavobacteriia,1EQE2@1016|Capnocytophaga 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Terminase_6 k59_12041_2 1249627.D779_3331 1.03e-09 57.0 COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,1S3WT@1236|Gammaproteobacteria,1WY7Z@135613|Chromatiales 135613|Chromatiales KT HD domain - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - HD_4 k59_58857_1 1123501.KB902294_gene3527 6.27e-35 135.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1042 Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_9914_2 1380346.JNIH01000022_gene3928 3.8e-64 205.0 COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.47 ko:K00034 ko00030,ko01120,ko01200,map00030,map01120,map01200 - R01520,R01521 RC00066 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_14464_1 1485544.JQKP01000002_gene1562 8.65e-68 223.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,44VJY@713636|Nitrosomonadales 28216|Betaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_60989_1 1131266.ARWQ01000028_gene1023 2.31e-73 222.0 COG1717@1|root,arCOG00781@2157|Archaea,41SP5@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02912 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L32e k59_60989_2 1229909.NSED_01880 9.59e-62 194.0 COG2147@1|root,arCOG04089@2157|Archaea,41SVC@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl19e - - ko:K02885 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19e k59_32188_1 1218084.BBJK01000149_gene7527 6.57e-05 51.2 COG0006@1|root,COG0006@2|Bacteria,1MX9N@1224|Proteobacteria,2VNKX@28216|Betaproteobacteria,1K3X3@119060|Burkholderiaceae 28216|Betaproteobacteria E Creatinase/Prolidase N-terminal domain - - 3.4.13.9,3.5.3.3 ko:K01271,ko:K08688 ko00260,ko00330,ko01100,map00260,map00330,map01100 - R01566 RC00548,RC00549 ko00000,ko00001,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_9942_1 1131266.ARWQ01000014_gene95 8.65e-44 146.0 COG1225@1|root,arCOG00310@2157|Archaea 2157|Archaea O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - Redoxin k59_36623_1 9940.ENSOARP00000022522 4.91e-22 93.6 2DZMN@1|root,2S74V@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_1182_1 472759.Nhal_0298 2.15e-86 257.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,1WY4X@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 1.20.4.1 ko:K03741,ko:K03892 - - - - ko00000,ko01000,ko03000 - - - HTH_5,LMWPc k59_56585_1 999541.bgla_1g05340 2.05e-126 370.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1K06J@119060|Burkholderiaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_14499_1 279303.Q6J7X8_9CAUD 2.63e-86 271.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_32224_1 485913.Krac_5504 6.44e-39 145.0 COG4584@1|root,COG4584@2|Bacteria 2|Bacteria L PFAM Integrase catalytic - - - - - - - - - - - - rve k59_7701_1 1266925.JHVX01000009_gene57 1.11e-93 285.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VIEP@28216|Betaproteobacteria,372II@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM aminotransferase, class I dapC - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_54389_1 391038.Bphy_3559 1.07e-26 110.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,1K2QQ@119060|Burkholderiaceae 28216|Betaproteobacteria I carboxylase accA1 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_54389_2 290400.Jann_3796 2.54e-06 50.8 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DctM k59_1204_1 640081.Dsui_1270 6.24e-96 292.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KUHV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_14525_1 402626.Rpic_3673 6.57e-27 108.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,1K464@119060|Burkholderiaceae 28216|Betaproteobacteria S signal peptide protein - - - - - - - - - - - - DUF4390 k59_14525_2 261292.Nit79A3_0451 1.97e-48 167.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,371PC@32003|Nitrosomonadales 28216|Betaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_67861_1 595536.ADVE02000001_gene298 1.86e-23 99.4 COG0863@1|root,COG0863@2|Bacteria,1R8XS@1224|Proteobacteria,2U18H@28211|Alphaproteobacteria,36Z9T@31993|Methylocystaceae 28211|Alphaproteobacteria L DNA methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_56608_1 59538.XP_005976861.1 2.04e-62 205.0 COG0015@1|root,KOG2700@2759|Eukaryota,395M8@33154|Opisthokonta,3BX18@33208|Metazoa,3DDKS@33213|Bilateria 33208|Metazoa F Adenylosuccinate lyase C-terminal - - - - - - - - - - - - ASL_C,Lyase_1 k59_47586_2 1123023.JIAI01000006_gene63 1.23e-15 77.4 COG1073@1|root,COG1073@2|Bacteria,2GK5B@201174|Actinobacteria,4E21E@85010|Pseudonocardiales 201174|Actinobacteria S Alpha/beta hydrolase of unknown function (DUF1100) - - - - - - - - - - - - DUF1100 k59_29879_1 6087.XP_002168097.2 3.09e-36 141.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_27701_1 323848.Nmul_A1002 2.04e-62 196.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,372NI@32003|Nitrosomonadales 28216|Betaproteobacteria O Glutathione S-transferase, N-terminal domain sspA - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_27701_2 1247649.D560_1555 1.22e-15 72.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,3T40B@506|Alcaligenaceae 28216|Betaproteobacteria S Stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_70015_1 1123401.JHYQ01000008_gene432 8.96e-47 167.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,4608C@72273|Thiotrichales 72273|Thiotrichales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_45541_1 666681.M301_2163 4.85e-31 121.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,2KKBP@206350|Nitrosomonadales 206350|Nitrosomonadales L PFAM DNA photolyase FAD-binding - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_45541_2 1266925.JHVX01000005_gene1854 7.86e-47 155.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,372DD@32003|Nitrosomonadales 28216|Betaproteobacteria K Belongs to the UPF0301 (AlgH) family algH - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_23294_1 1454004.AW11_01653 4.83e-82 261.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,1KQEU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_54427_1 55529.AAC35682 5.58e-19 86.7 COG0055@1|root,KOG1350@2759|Eukaryota 2759|Eukaryota C proton-transporting ATP synthase activity, rotational mechanism atpB GO:0000275,GO:0002376,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0005754,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008270,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009409,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009544,GO:0009570,GO:0009579,GO:0009605,GO:0009607,GO:0009620,GO:0009628,GO:0009814,GO:0009817,GO:0009987,GO:0010035,GO:0010038,GO:0010287,GO:0010319,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0031976,GO:0031977,GO:0031984,GO:0032991,GO:0033178,GO:0034220,GO:0034357,GO:0034641,GO:0034654,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0042651,GO:0043167,GO:0043169,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045087,GO:0045259,GO:0045261,GO:0045267,GO:0046034,GO:0046390,GO:0046483,GO:0046689,GO:0046872,GO:0046914,GO:0046933,GO:0050832,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0051707,GO:0055035,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098542,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098807,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112,ko:K02114,ko:K02133 ko00190,ko00195,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map00195,map01100,map04714,map05010,map05012,map05016 M00157,M00158 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N,ATP-synt_ab,ATP-synt_ab_N k59_16636_1 1131266.ARWQ01000001_gene1176 2.97e-62 202.0 arCOG08038@1|root,arCOG08038@2157|Archaea,41SZN@651137|Thaumarchaeota 651137|Thaumarchaeota S protein secretion by the type IV secretion system - - - - - - - - - - - - - k59_41138_1 436308.Nmar_0397 4.05e-100 297.0 COG0448@1|root,arCOG00912@2157|Archaea,41SEY@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate ornithine carbamoyltransferase carbamoyl-P binding domain - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_63393_1 994573.T472_0208070 1.66e-10 63.9 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,36F7Z@31979|Clostridiaceae 186801|Clostridia L Reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_18942_1 1131266.ARWQ01000014_gene89 3.4e-177 499.0 COG0604@1|root,arCOG01458@2157|Archaea,41SX7@651137|Thaumarchaeota 651137|Thaumarchaeota C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_56639_1 1380347.JNII01000009_gene1994 2.11e-93 296.0 COG1529@1|root,COG1529@2|Bacteria,2GIY7@201174|Actinobacteria,4ESUJ@85013|Frankiales 201174|Actinobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2,Fer2,Fer2_2 k59_63403_1 1163617.SCD_n00738 1.56e-17 87.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria 28216|Betaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_45040_2 1552758.NC00_03505 0.000118 45.4 28HEE@1|root,2Z7QU@2|Bacteria,1MXU6@1224|Proteobacteria,1RZSJ@1236|Gammaproteobacteria,1X530@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF932) - - - - - - - - - - - - DUF932 k59_51610_1 870187.Thini_2353 4.98e-30 115.0 2DNXC@1|root,32ZN4@2|Bacteria,1NKWP@1224|Proteobacteria,1SH3A@1236|Gammaproteobacteria,463C1@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_27257_2 1198452.Jab_1c16840 2.21e-29 105.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,474TV@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the sulfur carrier protein TusA family sirA - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_29378_1 13735.ENSPSIP00000000063 8.76e-55 184.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3A35Z@33154|Opisthokonta,3BQYF@33208|Metazoa,3D7GC@33213|Bilateria,48ICJ@7711|Chordata,49G95@7742|Vertebrata,4CMJX@8459|Testudines 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_69469_1 1131266.ARWQ01000001_gene1302 3.17e-52 167.0 COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota 651137|Thaumarchaeota C Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 k59_69469_2 1229909.NSED_09895 2.98e-13 68.9 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_4962_1 95619.PM1_0222000 7.78e-56 182.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RTIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family dcaE - - - - - - - - - - - ECH_1 k59_64984_1 1095769.CAHF01000022_gene265 6.61e-88 270.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VK72@28216|Betaproteobacteria,472EX@75682|Oxalobacteraceae 28216|Betaproteobacteria S Mo-co oxidoreductase dimerisation domain - - 1.8.2.1 ko:K05301 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00528 RC00168 ko00000,ko00001,ko01000 - - - Mo-co_dimer,Oxidored_molyb k59_7203_1 640081.Dsui_2449 2.07e-38 129.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,2KWX1@206389|Rhodocyclales 206389|Rhodocyclales IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_11638_2 436308.Nmar_0652 4.74e-54 177.0 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_29415_1 1124849.G9IAC1_9CAUD 1.33e-09 61.2 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales 28883|Caudovirales S phosphoprotein phosphatase activity - - - - - - - - - - - - - k59_62798_1 436308.Nmar_0284 6.2e-130 382.0 COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota 651137|Thaumarchaeota C plastoquinone (complex I) - - 1.6.5.3 ko:K00342,ko:K12137,ko:K12141 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_62798_2 1229909.NSED_01315 4.36e-12 61.2 COG0713@1|root,arCOG03073@2157|Archaea,41SPM@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_18371_1 436308.Nmar_0207 6.98e-121 357.0 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_22767_1 436308.Nmar_0085 2.91e-203 567.0 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_42820_1 279303.Q6J7X6_9CAUD 3.38e-99 324.0 4QAKM@10239|Viruses,4QZGT@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_665_1 1197906.CAJQ02000023_gene2270 2.19e-34 128.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3JRV2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Aminotransferase class-V MA20_43190 - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_665_2 1380394.JADL01000001_gene2976 1.85e-15 74.3 COG1082@1|root,COG1082@2|Bacteria,1R8NU@1224|Proteobacteria,2VDZU@28211|Alphaproteobacteria,2JUZV@204441|Rhodospirillales 204441|Rhodospirillales G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_53851_1 1163617.SCD_n02127 5.57e-74 250.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria 28216|Betaproteobacteria NU pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_69514_1 1229909.NSED_08150 7.31e-35 124.0 COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO k59_69514_2 1229909.NSED_08155 4.42e-95 284.0 COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_40555_1 1229909.NSED_01400 1.52e-60 196.0 COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - - k59_40555_2 436308.Nmar_0289 2.07e-38 132.0 COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_56129_1 436308.Nmar_1390 2.9e-54 178.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_56129_2 436308.Nmar_1391 1.31e-22 95.9 COG1498@1|root,arCOG01923@2157|Archaea,41SY9@651137|Thaumarchaeota 651137|Thaumarchaeota J NOSIC (NUC001) domain - - - ko:K14564 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - Nop k59_40568_1 1000565.METUNv1_02451 3.95e-56 196.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KV51@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_20614_1 436308.Nmar_1578 1.74e-99 304.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_58414_1 1100720.ALKN01000043_gene2689 4.9e-18 83.2 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VMVX@28216|Betaproteobacteria,4A9VB@80864|Comamonadaceae 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_49517_1 279303.Q6J7X6_9CAUD 2.02e-310 892.0 4QAKM@10239|Viruses,4QZGT@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_65048_1 436308.Nmar_1028 1.44e-157 449.0 COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota 651137|Thaumarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N k59_62836_1 436308.Nmar_0268 8.84e-147 416.0 COG0483@1|root,arCOG01349@2157|Archaea,41SIF@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_45092_1 323848.Nmul_A0510 9.09e-72 231.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VZIT@28216|Betaproteobacteria,371QJ@32003|Nitrosomonadales 28216|Betaproteobacteria O Trypsin - - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_31786_2 94624.Bpet0003 9.51e-45 161.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3T1KC@506|Alcaligenaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_5015_1 999541.bgla_1g06540 4.95e-76 236.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,1JZPH@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_29447_1 436308.Nmar_1627 7.69e-118 361.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_7260_2 159087.Daro_3090 3.69e-23 93.6 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,2KW2Z@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_27339_1 1304275.C41B8_00615 6.62e-59 205.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M mechanosensitive ion channel kefA GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K05802,ko:K22051 - - - - ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 - - MS_channel,MscS_TM,MscS_porin k59_51712_1 436308.Nmar_1793 2.45e-93 284.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_31809_1 713586.KB900536_gene1978 7.74e-24 102.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_34091_2 1207063.P24_03845 8.98e-46 155.0 COG3090@1|root,COG3090@2|Bacteria,1N0N7@1224|Proteobacteria,2U65H@28211|Alphaproteobacteria,2JX9C@204441|Rhodospirillales 204441|Rhodospirillales G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_51723_1 1156919.QWC_06774 7.96e-32 121.0 COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2VK4U@28216|Betaproteobacteria 28216|Betaproteobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_27341_1 349520.PPE_04180 5.49e-11 65.1 COG3963@1|root,COG3963@2|Bacteria,1V2ZK@1239|Firmicutes,4HGV5@91061|Bacilli,26UFE@186822|Paenibacillaceae 91061|Bacilli I Methyltransferase - - - - - - - - - - - - MTS,Methyltransf_11,Methyltransf_25,RrnaAD k59_53958_1 257313.BP3181 2.3e-107 324.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,3T6RN@506|Alcaligenaceae 28216|Betaproteobacteria S SpoVR family spoVR2 - - ko:K06415 - - - - ko00000 - - - SpoVR k59_53958_2 1122180.Lokhon_01314 4.37e-07 51.6 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,2TTWI@28211|Alphaproteobacteria,2P9PW@245186|Loktanella 28211|Alphaproteobacteria S Protein of unknown function (DUF444) - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_34123_1 1229909.NSED_06830 6.19e-145 424.0 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_36232_1 580332.Slit_2683 3.06e-38 130.0 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VUY2@28216|Betaproteobacteria,44VZ2@713636|Nitrosomonadales 28216|Betaproteobacteria D Cell division protein ZapA zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_2988_1 767817.Desgi_4213 4.54e-46 160.0 COG0615@1|root,COG0615@2|Bacteria,1VNXB@1239|Firmicutes 1239|Firmicutes IM Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_14067_1 358220.C380_13195 7.66e-94 290.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,4AABZ@80864|Comamonadaceae 28216|Betaproteobacteria T GAF domain - - - - - - - - - - - - GAF,HD,HD_5 k59_25097_1 279714.FuraDRAFT_0397 5.23e-59 192.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,2KPG2@206351|Neisseriales 206351|Neisseriales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_36252_1 1229909.NSED_01720 1.45e-107 313.0 COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota 651137|Thaumarchaeota S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_49553_1 395494.Galf_0583 1.84e-81 247.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,44VAX@713636|Nitrosomonadales 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_60626_1 546275.FUSPEROL_02385 1.98e-27 115.0 COG0749@1|root,COG0749@2|Bacteria,378G8@32066|Fusobacteria 32066|Fusobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,HHH_5 k59_9535_1 436308.Nmar_1003 1.34e-99 294.0 COG3741@1|root,arCOG08266@2157|Archaea 2157|Archaea E N-formylglutamate amidohydrolase - - 3.5.3.8 ko:K01479 ko00340,ko01100,map00340,map01100 M00045 R02285 RC00221,RC00681 ko00000,ko00001,ko00002,ko01000 - - - FGase k59_31829_1 748280.NH8B_2255 7.12e-77 244.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria 28216|Betaproteobacteria O serine protease nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_9539_1 1215092.PA6_009_01100 1.52e-38 135.0 COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,1SAAN@1236|Gammaproteobacteria,1YGQ8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Cytochrome c mono- and diheme variants - - - - - - - - - - - - Cytochrom_C k59_68782_1 436308.Nmar_1549 1.46e-105 315.0 COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_59880_1 323097.Nham_3886 3.4e-103 311.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_55377_1 436308.Nmar_1690 2.39e-120 355.0 COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit atpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_59894_1 279303.Q6J7X8_9CAUD 4.68e-129 386.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_33265_1 7029.ACYPI36962-PA 1.94e-12 73.6 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,PRE_C2HC,RVT_1 k59_53200_1 436308.Nmar_1503 8.3e-85 253.0 arCOG08675@1|root,arCOG08675@2157|Archaea,41SI5@651137|Thaumarchaeota 651137|Thaumarchaeota C Monooxygenase subunit B protein - - - ko:K10945 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002 - - - Monooxygenase_B k59_28767_1 1229909.NSED_08960 3.34e-06 48.1 COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_28767_2 1229909.NSED_08955 5.2e-150 424.0 COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_18086_2 7668.SPU_020768-tr 2.83e-100 338.0 29Q9H@1|root,2RX81@2759|Eukaryota,39ZQJ@33154|Opisthokonta,3BNMR@33208|Metazoa,3D95F@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - DUF4371,Dimer_Tnp_hAT k59_69231_1 1229909.NSED_08705 2.78e-217 607.0 COG1012@1|root,arCOG01252@2157|Archaea,41T0F@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135,ko:K18601 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_31416_1 1288494.EBAPG3_23410 4.18e-118 362.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM glycosyl transferase, family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_29137_2 909663.KI867150_gene2770 1.06e-29 123.0 COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - UPF0236 k59_11407_1 106582.XP_004570078.1 2.23e-73 245.0 COG2801@1|root,KOG4585@1|root,KOG0017@2759|Eukaryota,KOG4585@2759|Eukaryota,39THK@33154|Opisthokonta,3BGF1@33208|Metazoa,3D09T@33213|Bilateria,48E2J@7711|Chordata,49BQC@7742|Vertebrata,4A3KG@7898|Actinopterygii 33208|Metazoa L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_4 k59_29157_1 436308.Nmar_1707 7.96e-98 287.0 COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota 651137|Thaumarchaeota F thymidylate kinase tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_29157_2 436308.Nmar_1706 1.51e-06 48.5 COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD k59_22535_1 10224.XP_006811646.1 1.61e-19 92.8 KOG1075@1|root,KOG1075@2759|Eukaryota,3A4K9@33154|Opisthokonta,3BSC4@33208|Metazoa,3D93E@33213|Bilateria 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_29160_1 1173021.ALWA01000037_gene3499 8.98e-52 171.0 COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria 1117|Cyanobacteria J Histone methylation protein DOT1 - - - - - - - - - - - - Methyltransf_31 k59_62538_1 7668.SPU_019910-tr 1.37e-83 263.0 2CXRP@1|root,2RZ9M@2759|Eukaryota,3A84X@33154|Opisthokonta,3BTAV@33208|Metazoa,3DA4U@33213|Bilateria 33208|Metazoa S DDE superfamily endonuclease - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464 - - - - - - - - - - DDE_3,HTH_38,HTH_Tnp_Tc3_1,HTH_Tnp_Tc3_2 k59_2604_1 370438.PTH_2271 3.25e-35 136.0 COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia 186801|Clostridia F Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03458 - - - - ko00000 2.A.40 - - Xan_ur_permease k59_18109_1 31033.ENSTRUP00000009003 5.19e-149 452.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3C2B0@33208|Metazoa,3E4PI@33213|Bilateria,48M6I@7711|Chordata,49I3R@7742|Vertebrata 33208|Metazoa L retrotransposable element Tf2 155 kDa protein type 1-like - - - - - - - - - - - - RVT_1,rve k59_58138_1 436308.Nmar_1445 3.98e-32 116.0 arCOG08730@1|root,arCOG08730@2157|Archaea,41SNH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_58138_2 436308.Nmar_1446 1.85e-41 137.0 COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_62555_1 1229909.NSED_09340 5.71e-29 113.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_62555_2 436308.Nmar_1753 3.11e-101 308.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_13700_1 436308.Nmar_1755 1.03e-112 327.0 COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota 651137|Thaumarchaeota L Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication pcn - - ko:K04802 ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166 M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - PCNA_C,PCNA_N k59_27017_1 1173026.Glo7428_2825 4.73e-45 150.0 COG0614@1|root,COG0614@2|Bacteria,1G73G@1117|Cyanobacteria 1117|Cyanobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_13710_1 1236959.BAMT01000017_gene2354 2.41e-77 249.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KKTM@206350|Nitrosomonadales 206350|Nitrosomonadales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_64794_1 436308.Nmar_0558 1.37e-13 72.0 arCOG08027@1|root,arCOG08027@2157|Archaea,41T8U@651137|Thaumarchaeota 2157|Archaea D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity - - - ko:K22222 - - - - ko00000,ko04812 - - - - k59_35958_1 1229909.NSED_02760 2.56e-107 315.0 COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_40328_1 1229909.NSED_00615 2.71e-106 322.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_33733_1 1280944.HY17_04645 8.31e-51 186.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria,2UM25@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_24840_1 554065.XP_005845391.1 4.63e-08 59.7 COG0141@1|root,KOG4439@2759|Eukaryota 2759|Eukaryota E ATP binding - - - ko:K15083,ko:K15173 ko04918,map04918 - - - ko00000,ko00001,ko01000,ko03021,ko03400 - - - Helicase_C,SNF2_N k59_22578_1 558152.IQ37_17995 1.85e-09 60.8 COG5485@1|root,COG5485@2|Bacteria,4NQC7@976|Bacteroidetes,1IAJB@117743|Flavobacteriia 976|Bacteroidetes S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_9301_1 436308.Nmar_1794 2.36e-151 457.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_51411_3 279303.Q6J7Y5_9CAUD 1.77e-44 150.0 4QF9J@10239|Viruses,4QX1U@35237|dsDNA viruses no RNA stage,4QQQ0@28883|Caudovirales,4QM91@10699|Siphoviridae 10699|Siphoviridae S Crossover junction endodeoxyribonuclease RuvC - - - - - - - - - - - - - k59_2653_1 765911.Thivi_3661 6.32e-65 211.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1WXTE@135613|Chromatiales 135613|Chromatiales S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_33758_1 76114.ebA6690 2.35e-69 227.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,2KV73@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_40356_1 1049564.TevJSym_ab00410 5.95e-57 194.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1J50Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp k59_18150_1 1121440.AUMA01000022_gene2037 4.71e-45 160.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_38179_2 638303.Thal_1246 1.02e-05 52.4 COG0749@1|root,COG0749@2|Bacteria,2G4NU@200783|Aquificae 200783|Aquificae L DNA polymerase polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_pol_A,DNA_pol_A_exo1 k59_2669_1 13735.ENSPSIP00000000745 7.05e-50 169.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_391_1 105559.Nwat_1954 1.94e-41 138.0 arCOG11477@1|root,32TJG@2|Bacteria,1MYXX@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_391_2 76114.ebA6730 1.14e-08 55.8 2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2W0ZB@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_64841_1 270374.MELB17_21395 3.8e-28 111.0 COG0715@1|root,COG0715@2|Bacteria,1R5S6@1224|Proteobacteria,1RZSB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_22600_1 6669.EFX64917 4.97e-26 112.0 2ENCB@1|root,2SRU3@2759|Eukaryota,39MTA@33154|Opisthokonta,3CPD2@33208|Metazoa,3E5HQ@33213|Bilateria,42AIU@6656|Arthropoda 2759|Eukaryota S Endonuclease-reverse transcriptase - - - - - - - - - - - - Exo_endo_phos_2 k59_18169_1 1304275.C41B8_03226 2.41e-08 56.6 COG0028@1|root,COG0028@2|Bacteria,1MWVW@1224|Proteobacteria,1RPZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6,4.1.1.75 ko:K01652,ko:K12253 ko00290,ko00330,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00330,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R03178,R04672,R04673,R08648 RC00027,RC00106,RC00506,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_13758_1 1229909.NSED_09395 1.73e-86 257.0 COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota 651137|Thaumarchaeota T Dual specificity phosphatase, catalytic domain - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc k59_31531_1 1229909.NSED_09925 2.67e-109 320.0 COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_31531_2 1131266.ARWQ01000001_gene1298 1.33e-45 153.0 COG2243@1|root,arCOG00648@2157|Archaea,41SGJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_40369_1 8153.XP_005952986.1 5.34e-86 296.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BPSU@33208|Metazoa,3E41R@33213|Bilateria,48QRC@7711|Chordata,49MB3@7742|Vertebrata,4A94E@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_7034_1 1229909.NSED_09745 7.24e-62 203.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_52335_2 1122951.ATUE01000005_gene2190 7.39e-09 57.0 COG0348@1|root,COG0348@2|Bacteria,1R9JQ@1224|Proteobacteria,1RRYK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_36883_1 1120983.KB894578_gene3830 8.68e-67 213.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TTFX@28211|Alphaproteobacteria,1JPR6@119043|Rhodobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_7943_1 1288494.EBAPG3_28130 1.17e-84 261.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_7943_2 557598.LHK_03052 6.71e-18 82.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,2KR2D@206351|Neisseriales 206351|Neisseriales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_61277_1 1229909.NSED_09305 6.93e-97 291.0 COG0399@1|root,arCOG00118@2157|Archaea,41S96@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_56270_2 436308.Nmar_0318 2.57e-29 105.0 COG1644@1|root,arCOG04244@2157|Archaea,41SPN@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoN - 2.7.7.6 ko:K03058 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_N k59_60676_1 436308.Nmar_0481 8.36e-80 246.0 COG0573@1|root,arCOG00167@2157|Archaea,41SYE@651137|Thaumarchaeota 651137|Thaumarchaeota P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_47339_1 10228.TriadP33902 6.98e-13 61.6 2DZEY@1|root,2S6ZB@2759|Eukaryota,3A8VS@33154|Opisthokonta,3BUFV@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - - k59_47339_2 13735.ENSPSIP00000001938 2.91e-10 65.1 29K1R@1|root,2RTAM@2759|Eukaryota,39YR1@33154|Opisthokonta,3BPA4@33208|Metazoa,3D0TK@33213|Bilateria,48CB2@7711|Chordata,496S2@7742|Vertebrata 33208|Metazoa - - - - - - - - - - - - - - - k59_27396_1 1459636.NTE_02904 1.7e-86 270.0 arCOG01319@1|root,arCOG01319@2157|Archaea 2157|Archaea S Sodium:solute symporter family - - - - - - - - - - - - SSF k59_58551_1 314270.RB2083_2915 1.35e-25 105.0 COG1593@1|root,COG1593@2|Bacteria,1N1HM@1224|Proteobacteria,2TR8B@28211|Alphaproteobacteria,3ZI3W@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria G Trap dicarboxylate transporter-dctm subunit - - - - - - - - - - - - DctM k59_58551_2 411684.HPDFL43_07849 5.8e-21 88.2 COG3090@1|root,COG3090@2|Bacteria,1RA8Q@1224|Proteobacteria,2U67A@28211|Alphaproteobacteria 28211|Alphaproteobacteria G TRAP-type C4-dicarboxylate transport system small permease component - - - - - - - - - - - - DctQ k59_11770_1 1197477.IA57_01105 7.56e-06 49.3 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IJXT@117743|Flavobacteriia 976|Bacteroidetes M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_11770_2 1089553.Tph_c24250 5.18e-134 397.0 COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales 186801|Clostridia L Transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_20720_1 13735.ENSPSIP00000000799 1.74e-91 288.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_29529_1 436308.Nmar_1788 5.44e-30 107.0 arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_29529_2 436308.Nmar_1787 2.38e-48 154.0 COG3582@1|root,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - zf-AN1 k59_29529_3 1229909.NSED_09565 9.42e-149 421.0 COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_25176_1 511.JT27_09345 2.12e-42 151.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,3T2JI@506|Alcaligenaceae 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_67418_1 1265502.KB905952_gene808 3.68e-74 236.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,4AA1P@80864|Comamonadaceae 28216|Betaproteobacteria S Flavocytochrome c sulphide dehydrogenase, flavin-binding soxF - 1.8.2.1,1.8.5.4 ko:K05301,ko:K17218 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00528,R10152 RC00168,RC03155 ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_29533_2 1121912.AUHD01000003_gene3023 1.63e-26 103.0 COG3187@1|root,COG3187@2|Bacteria,4PKCG@976|Bacteroidetes 976|Bacteroidetes O Domain of unknown function (DUF4377) - - - - - - - - - - - - DUF4377,META k59_38573_1 436308.Nmar_1614 2.28e-17 78.6 COG2429@1|root,arCOG04202@2157|Archaea,41SHK@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity gch3 - 3.5.4.29 ko:K08096 ko00740,ko01100,map00740,map01100 - R07306 RC01790 ko00000,ko00001,ko01000 - - - GCH_III k59_38573_2 436308.Nmar_1615 1.63e-76 230.0 COG0054@1|root,arCOG01323@2157|Archaea,41SQ6@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_60686_1 1000565.METUNv1_02932 1.17e-108 320.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,2KUF5@206389|Rhodocyclales 206389|Rhodocyclales H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_49632_1 1229909.NSED_00415 2.25e-136 386.0 COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota 651137|Thaumarchaeota S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - Polyketide_cyc2 k59_25187_1 1225184.ALXE01000025_gene2156 1.77e-28 108.0 COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,1S73A@1236|Gammaproteobacteria,3W2CJ@53335|Pantoea 1236|Gammaproteobacteria M Cell Wall Hydrolase - - - - - - - - - - - - Hydrolase_2 k59_65168_1 688245.CtCNB1_2372 2.57e-29 113.0 COG2867@1|root,COG2867@2|Bacteria,1R01P@1224|Proteobacteria,2WHS4@28216|Betaproteobacteria 28216|Betaproteobacteria I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_42965_3 12345.Q96206_BPGA1 1.98e-05 56.2 4QAWD@10239|Viruses,4QVNG@35237|dsDNA viruses no RNA stage,4QQCM@28883|Caudovirales,4QNB7@10744|Podoviridae 10744|Podoviridae S nucleotide binding - - - - - - - - - - - - - k59_58579_2 1120999.JONM01000008_gene2006 1e-18 83.2 COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,2KSUN@206351|Neisseriales 206351|Neisseriales KT Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_27412_1 1229909.NSED_09730 2.48e-44 143.0 arCOG08662@1|root,arCOG08662@2157|Archaea 1229909.NSED_09730|- - - - - - - - - - - - - - - - k59_27412_2 1229909.NSED_00900 3.52e-60 191.0 COG0071@1|root,arCOG01832@2157|Archaea,41T6B@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_40741_1 365046.Rta_03940 1.43e-22 97.1 COG1215@1|root,COG3222@1|root,COG1215@2|Bacteria,COG3222@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria,4ADRH@80864|Comamonadaceae 28216|Betaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_40741_2 1255043.TVNIR_2414 6.1e-24 101.0 COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1X13W@135613|Chromatiales 135613|Chromatiales CE AIR synthase related protein, N-terminal domain - - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C,Pyr_redox_2 k59_16308_1 1392838.AWNM01000009_gene2757 3.98e-122 358.0 COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VHQ4@28216|Betaproteobacteria,3T5CN@506|Alcaligenaceae 28216|Betaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_20738_1 159749.E7BWF3 3.86e-22 100.0 2CACG@1|root,2RWZ1@2759|Eukaryota,2XE6M@2836|Bacillariophyta 2836|Bacillariophyta S Uncharacterised protein family ycf90 - - - - - - - - - - - YCF90 k59_16309_1 1116369.KB890024_gene1623 9.04e-86 261.0 COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,43P0N@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Formyl transferase, C-terminal domain - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_63764_1 1229909.NSED_00810 0.000338 40.8 COG0640@1|root,arCOG00731@2157|Archaea,41T40@651137|Thaumarchaeota 651137|Thaumarchaeota K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_5 k59_50248_1 436308.Nmar_0043 1.62e-73 230.0 COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota 651137|Thaumarchaeota S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_14913_1 261292.Nit79A3_0379 8.36e-80 243.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,3724S@32003|Nitrosomonadales 28216|Betaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_59265_1 1229909.NSED_03355 9.74e-97 310.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_25786_1 279303.Q6J817_9CAUD 3.36e-104 319.0 4QG9U@10239|Viruses,4R0A6@35237|dsDNA viruses no RNA stage,4QSKC@28883|Caudovirales,4QM4R@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_25787_1 1247726.MIM_c27800 0.000736 41.2 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,3T2V8@506|Alcaligenaceae 28216|Betaproteobacteria G in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_25787_2 1437824.BN940_15296 2.4e-95 286.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,3T31E@506|Alcaligenaceae 28216|Betaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_30285_1 748247.AZKH_0070 1.18e-36 133.0 COG0746@1|root,COG0746@2|Bacteria,1NBH1@1224|Proteobacteria,2WFP1@28216|Betaproteobacteria,2KXTC@206389|Rhodocyclales 206389|Rhodocyclales H Protein of unknown function (DUF3305) - - - - - - - - - - - - DUF3305 k59_59272_1 1410619.SRDD_27080 2.12e-94 290.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_19286_1 1123296.JQKE01000005_gene75 2.85e-21 94.4 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,2KPXX@206351|Neisseriales 206351|Neisseriales M Transglycosylase SLT domain protein sltY - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_19286_2 292415.Tbd_2361 4.16e-24 101.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1KSTJ@119069|Hydrogenophilales 119069|Hydrogenophilales GM Saccharopine dehydrogenase NADP binding domain - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase k59_47969_1 864073.HFRIS_003073 7.46e-31 124.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,473A1@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal - - 2.7.13.3 ko:K07649 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_61424_1 1211115.ALIQ01000130_gene2673 7.75e-06 53.9 COG4675@1|root,COG4675@2|Bacteria,1NBU9@1224|Proteobacteria 1224|Proteobacteria S tail collar domain protein - - - - - - - - - - - - - k59_17020_1 395493.BegalDRAFT_2506 5.93e-65 210.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_12504_1 420324.KI911934_gene172 9.19e-119 349.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_68215_1 13735.ENSPSIP00000001021 3.38e-25 107.0 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_43738_1 543728.Vapar_4821 1.02e-39 144.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9RE@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_57071_1 416591.Tlet_1876 1.23e-36 139.0 COG3333@1|root,COG3333@2|Bacteria,2GDV9@200918|Thermotogae 200918|Thermotogae S PFAM Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_14978_1 1380394.JADL01000009_gene3164 3e-100 308.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JPPV@204441|Rhodospirillales 204441|Rhodospirillales E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_43752_1 1007105.PT7_0807 4.21e-104 309.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,3T2W1@506|Alcaligenaceae 28216|Betaproteobacteria G C4-dicarboxylate ABC transporter - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_3872_1 1121413.JMKT01000009_gene1936 3.65e-95 285.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2WJR5@28221|Deltaproteobacteria,2MAEE@213115|Desulfovibrionales 28221|Deltaproteobacteria M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - LysM,MS_channel,TM_helix k59_23746_1 1231391.AMZF01000007_gene1474 6.75e-108 319.0 COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2WED9@28216|Betaproteobacteria,3T4WG@506|Alcaligenaceae 28216|Betaproteobacteria P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_56390_1 102129.Lepto7375DRAFT_6340 1.13e-68 226.0 COG3464@1|root,COG3464@2|Bacteria,1G6BF@1117|Cyanobacteria,1HFBN@1150|Oscillatoriales 1117|Cyanobacteria L IMG reference gene - - - - - - - - - - - - - k59_65278_1 1229909.NSED_00600 1.22e-07 51.2 COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota 651137|Thaumarchaeota M MobA-like NTP transferase domain - - 2.7.7.62 ko:K19712 ko00860,ko01100,map00860,map01100 - R05222 RC00002 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_65278_2 1229909.NSED_00595 2.03e-73 226.0 COG0368@1|root,arCOG04338@2157|Archaea,41SI6@651137|Thaumarchaeota 651137|Thaumarchaeota H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_18654_1 1380390.JIAT01000012_gene3012 1.49e-14 73.9 COG3435@1|root,COG3435@2|Bacteria,2GKAE@201174|Actinobacteria,4CSJA@84995|Rubrobacteria 84995|Rubrobacteria Q Cupin domain - - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_40862_1 1229909.NSED_06205 7.66e-10 56.2 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_40862_2 436308.Nmar_1058 6.13e-49 162.0 arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota 651137|Thaumarchaeota S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_7508_2 28377.ENSACAP00000021029 1.66e-77 247.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39VM0@33154|Opisthokonta,3BKMM@33208|Metazoa,3D1CS@33213|Bilateria,48RU4@7711|Chordata,49N7J@7742|Vertebrata 33208|Metazoa S Endonuclease-reverse transcriptase - - - - - - - - - - - - Exo_endo_phos,Exo_endo_phos_2 k59_11904_1 436308.Nmar_0308 2.68e-60 186.0 COG2146@1|root,arCOG02852@2157|Archaea,41SSE@651137|Thaumarchaeota 651137|Thaumarchaeota P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_11904_2 436308.Nmar_0309 5.98e-44 150.0 COG0454@1|root,arCOG00845@2157|Archaea,41T5Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_65303_1 1131553.JIBI01000039_gene1942 4.7e-101 309.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,3728R@32003|Nitrosomonadales 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA2 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_67612_1 2340.JV46_05690 1.42e-115 340.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_58688_1 153948.NAL212_2499 3.62e-121 358.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,371NT@32003|Nitrosomonadales 28216|Betaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_67613_1 296591.Bpro_0285 1.45e-31 120.0 COG0834@1|root,COG0834@2|Bacteria,1N2RR@1224|Proteobacteria,2VTMG@28216|Betaproteobacteria 28216|Betaproteobacteria ET ABC transporter substrate-binding protein - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_36399_1 1485544.JQKP01000002_gene1427 1.07e-56 185.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,44VG9@713636|Nitrosomonadales 28216|Betaproteobacteria V PFAM ABC transporter related nodI - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran k59_36399_2 395494.Galf_2738 5.69e-12 63.5 COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,2VJ7R@28216|Betaproteobacteria,44W6T@713636|Nitrosomonadales 28216|Betaproteobacteria V PFAM ABC-2 type transporter nodJ - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_58701_1 1198452.Jab_1c21120 8.88e-14 71.2 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,472F0@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_58701_2 748247.AZKH_0440 1.57e-51 167.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,2KW8Z@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_60843_1 1229909.NSED_09785 2.05e-19 83.2 arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_60847_1 1163617.SCD_n02434 3.16e-72 246.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria 28216|Betaproteobacteria G 4-alpha-glucanotransferase treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_65307_1 1266925.JHVX01000018_gene1825 4.34e-112 332.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,372HU@32003|Nitrosomonadales 28216|Betaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_54186_1 76114.ebA723 3.77e-72 224.0 COG1028@1|root,COG1028@2|Bacteria,1RCD5@1224|Proteobacteria,2W04R@28216|Betaproteobacteria,2KXRA@206389|Rhodocyclales 206389|Rhodocyclales IQ KR domain - - - ko:K07535 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05582 RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_58720_1 522306.CAP2UW1_3496 5.47e-168 489.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VI3Q@28216|Betaproteobacteria,1KPVF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_32046_1 743299.Acife_1037 3.56e-17 75.5 COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S90G@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - - k59_32046_2 269799.Gmet_0317 4.15e-25 97.1 COG2944@1|root,COG2944@2|Bacteria,1N5H0@1224|Proteobacteria,43B8E@68525|delta/epsilon subdivisions 1224|Proteobacteria K Helix-turn-helix XRE-family like proteins - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3,HTH_31,MqsA_antitoxin k59_18694_1 279303.Q6J816_9CAUD 7.76e-63 199.0 4QF9N@10239|Viruses,4QUNU@35237|dsDNA viruses no RNA stage,4QRT6@28883|Caudovirales,4QKQH@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_18694_2 279303.Q6J815_9CAUD 2.11e-133 381.0 4QGJF@10239|Viruses,4QZE7@35237|dsDNA viruses no RNA stage,4QU68@28883|Caudovirales,4QMKG@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_58733_1 436308.Nmar_1120 5.67e-110 344.0 COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_51962_1 1229909.NSED_08950 8.08e-96 285.0 COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_51962_2 436308.Nmar_1652 4.07e-15 73.9 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_67660_1 1131266.ARWQ01000001_gene1357 5.92e-64 201.0 COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_67660_2 1229909.NSED_09570 1.2e-34 119.0 COG3582@1|root,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - zf-AN1 k59_69844_1 1163617.SCD_n02025 6.58e-101 305.0 COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2VKBR@28216|Betaproteobacteria 28216|Betaproteobacteria CP NADH Ubiquinone plastoquinone (Complex I) hyfF - - ko:K12141 - - - - ko00000,ko01000 - - - Proton_antipo_M k59_9782_1 436308.Nmar_1260 1.76e-110 329.0 COG1027@1|root,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_9782_2 436308.Nmar_1261 3.68e-27 107.0 COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota 651137|Thaumarchaeota J MiaB-like tRNA modifying enzyme - - 2.8.4.5 ko:K15865 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_56486_1 1229909.NSED_02510 3.12e-114 336.0 COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_3315_1 709797.CSIRO_0066 6.37e-85 269.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,3JVAX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_18735_1 987059.RBXJA2T_18748 4.89e-07 49.3 COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2VSS8@28216|Betaproteobacteria,1KM8I@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind k59_18735_2 365044.Pnap_4550 1.05e-32 117.0 COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,4AFJQ@80864|Comamonadaceae 28216|Betaproteobacteria S Copper binding periplasmic protein CusF cusF - - - - - - - - - - - CusF_Ec k59_25318_1 436308.Nmar_0578 8.52e-94 290.0 COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_35995_1 926569.ANT_12310 3.69e-27 104.0 COG3293@1|root,COG3293@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_31554_1 264198.Reut_B4136 3.96e-60 197.0 COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2VMND@28216|Betaproteobacteria,1K120@119060|Burkholderiaceae 28216|Betaproteobacteria G Periplasmic binding proteins and sugar binding domain of LacI family rbsB - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_69295_1 7668.SPU_009536-tr 2.2e-32 132.0 KOG1075@1|root,KOG3538@1|root,KOG1075@2759|Eukaryota,KOG3538@2759|Eukaryota,3APWC@33154|Opisthokonta,3C20X@33208|Metazoa 2759|Eukaryota O Reverse transcriptase (RNA-dependent DNA polymerase) - - - ko:K08625 - - - - ko00000,ko01000,ko01002 - - - ADAM_spacer1,EGF,Ephrin_rec_like,GON,HYR,Reprolysin,Reprolysin_5,Sushi,TSP_1,Xlink,hEGF k59_49316_2 436308.Nmar_0919 2.16e-13 68.9 COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_67093_1 1549858.MC45_16510 5.25e-67 219.0 COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,1MVEI@1224|Proteobacteria,2V9FS@28211|Alphaproteobacteria,2K9HC@204457|Sphingomonadales 204457|Sphingomonadales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.5 ko:K01027 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_49322_1 436308.Nmar_0210 4.63e-27 100.0 COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_49322_2 1229909.NSED_00850 3.17e-77 236.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_29250_1 13616.ENSMODP00000030103 5.64e-31 123.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39VM0@33154|Opisthokonta,3BPUP@33208|Metazoa,3D6HY@33213|Bilateria,48CXU@7711|Chordata,4992I@7742|Vertebrata,3JJKA@40674|Mammalia 33208|Metazoa S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos,Exo_endo_phos_2 k59_58222_1 1229909.NSED_03305 1.6e-140 399.0 arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_49323_1 1266925.JHVX01000006_gene2235 8.74e-63 212.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria,372J9@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_55959_1 398525.KB900701_gene6379 2.84e-82 266.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_27125_1 1229909.NSED_03205 1.99e-42 140.0 COG0023@1|root,arCOG04223@2157|Archaea,41SNU@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the SUI1 family - - - ko:K03113 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - SUI1 k59_27125_2 1229909.NSED_03210 8.48e-56 185.0 arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota 651137|Thaumarchaeota E CAAX protease self-immunity - - - - - - - - - - - - Abi k59_47097_1 1229909.NSED_08280 2.38e-68 212.0 arCOG08673@1|root,arCOG08673@2157|Archaea,41SVK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_4853_2 1229909.NSED_01910 2.41e-119 353.0 COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_69328_1 1229909.NSED_01200 6.38e-45 147.0 COG2142@1|root,arCOG04162@2157|Archaea,41SRA@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_69328_2 436308.Nmar_0259 1.19e-86 255.0 COG2009@1|root,arCOG02244@2157|Archaea,41SKZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_49327_1 1229909.NSED_00840 2.74e-77 239.0 arCOG10597@1|root,arCOG10597@2157|Archaea 1229909.NSED_00840|- O serine-type endopeptidase activity - - - - - - - - - - - - - k59_58229_1 497321.C664_02680 5.37e-49 166.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,2KUP3@206389|Rhodocyclales 206389|Rhodocyclales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_62667_1 1173022.Cri9333_0059 1.63e-40 140.0 COG0614@1|root,COG0614@2|Bacteria,1G73G@1117|Cyanobacteria,1HFHX@1150|Oscillatoriales 1117|Cyanobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_62672_1 1169143.KB911049_gene5579 6.51e-21 92.8 COG2207@1|root,COG2207@2|Bacteria,1MY46@1224|Proteobacteria,2W1XW@28216|Betaproteobacteria,1KFVM@119060|Burkholderiaceae 28216|Betaproteobacteria K Cupin - - - - - - - - - - - - Cupin_6,HTH_18 k59_27142_1 1229909.NSED_09640 3.14e-111 330.0 COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in regulation of DNA replication - - - ko:K10725 - - - - ko00000,ko03032 - - - AAA_22,Cdc6_C k59_27142_2 1229909.NSED_09645 2.92e-22 94.4 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_27159_1 85643.Tmz1t_2773 2.93e-102 313.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,2KUZP@206389|Rhodocyclales 206389|Rhodocyclales H COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_11562_1 1229909.NSED_04235 3.08e-23 90.1 arCOG10545@1|root,arCOG10545@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_11562_2 1229909.NSED_04230 4.47e-58 184.0 arCOG11447@1|root,arCOG11447@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_7122_1 1163617.SCD_n01778 6.5e-52 178.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria 28216|Betaproteobacteria H squalene-associated FAD-dependent desaturase hpnE - 1.17.8.1 ko:K21677 - - - - ko00000,ko01000 - - - Amino_oxidase k59_47106_1 153948.NAL212_0668 2.01e-89 271.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,371X7@32003|Nitrosomonadales 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_47107_1 1229909.NSED_09495 5.67e-148 426.0 COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - - k59_29294_1 1131266.ARWQ01000001_gene1148 4.8e-20 91.3 COG2047@1|root,arCOG00348@2157|Archaea,41SFT@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K07159 - - - - ko00000 - - - PAC2 k59_29305_1 1229909.NSED_09340 8.39e-100 304.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_44970_1 1266925.JHVX01000008_gene239 2.36e-98 300.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,371M5@32003|Nitrosomonadales 28216|Betaproteobacteria C FAD linked oxidases, C-terminal domain glcD - 1.1.2.4,1.1.3.15,1.1.5.12 ko:K00102,ko:K00104,ko:K03777 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475,R00704,R11591 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_53734_1 748280.NH8B_0186 8.63e-101 302.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,2KPZN@206351|Neisseriales 206351|Neisseriales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_41289_1 709797.CSIRO_1196 8.64e-13 70.5 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,3JRC4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DUF3394,DctM k59_41289_2 1411123.JQNH01000001_gene2712 2.14e-29 113.0 COG2358@1|root,COG2358@2|Bacteria,1NSZ5@1224|Proteobacteria,2U3NZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system periplasmic component - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_14684_1 8128.ENSONIP00000026369 8.45e-43 155.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49ADZ@7742|Vertebrata,4A4QB@7898|Actinopterygii 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_32410_1 402626.Rpic_0340 2.43e-40 140.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,1JZZY@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_32410_2 314607.KB13_1060 5.33e-41 149.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1KPR9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_23440_1 267608.RSc2462 7e-61 198.0 COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VP68@28216|Betaproteobacteria,1K1EY@119060|Burkholderiaceae 28216|Betaproteobacteria C luciferase - - - - - - - - - - - - Bac_luciferase k59_70189_1 867845.KI911784_gene3292 1.52e-47 154.0 COG2343@1|root,COG2343@2|Bacteria,2G79F@200795|Chloroflexi,377I0@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_70189_2 1122165.AUHS01000025_gene1474 1.53e-44 152.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1JCXN@118969|Legionellales 118969|Legionellales L Endonuclease/Exonuclease/phosphatase family xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_63562_1 762903.Pedsa_2411 3.01e-22 101.0 COG2911@1|root,COG3209@1|root,COG3391@1|root,COG4386@1|root,COG4677@1|root,COG4932@1|root,COG5184@1|root,COG5492@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,COG4386@2|Bacteria,COG4677@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,4NHHA@976|Bacteroidetes,1IVM6@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3 k59_1335_1 323848.Nmul_A2069 4.6e-79 252.0 COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales 28216|Betaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_41303_1 1244869.H261_03133 1.66e-49 169.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E benzoyl-CoA reductase - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_41303_2 316057.RPD_1536 8.96e-20 88.6 COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Benzoyl-CoA reductase subunit - - 1.3.7.8 ko:K04114 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG k59_54602_1 27923.ML23185a-PA 6.15e-16 80.5 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa 33208|Metazoa G Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_56796_1 1255043.TVNIR_0881 3.6e-74 243.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_63567_1 1229909.NSED_08165 4.81e-94 296.0 COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota 651137|Thaumarchaeota C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_65646_1 626887.J057_23805 9.04e-51 176.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria,46AN4@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_39074_1 1229909.NSED_09335 5.33e-102 308.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_65648_1 261292.Nit79A3_2017 1.27e-38 131.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,373A6@32003|Nitrosomonadales 28216|Betaproteobacteria S Belongs to the HesB IscA family iscA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_65648_2 261292.Nit79A3_2018 4.28e-50 171.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2VJMX@28216|Betaproteobacteria,3724U@32003|Nitrosomonadales 28216|Betaproteobacteria O Uncharacterized protein family (UPF0051) sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_34830_1 1229909.NSED_01675 9.72e-09 55.1 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_34830_2 436308.Nmar_0349 1.31e-36 124.0 COG1958@1|root,arCOG00998@2157|Archaea 2157|Archaea K Like-Sm ribonucleoprotein core lsm GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K04796 - - - - ko00000 - - - LSM k59_34830_3 1229909.NSED_01685 3.85e-108 322.0 arCOG08777@1|root,arCOG08800@1|root,arCOG08777@2157|Archaea,arCOG08800@2157|Archaea 2157|Archaea L metallopeptidase activity - - - - - - - - - - - - CHB_HEX_C_1,Polysacc_deac_1 k59_70232_1 436308.Nmar_1309 1.67e-106 326.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_45704_1 1408423.JHYA01000001_gene869 7.25e-09 65.5 COG3598@1|root,COG3598@2|Bacteria,1UIBK@1239|Firmicutes,4H7TV@909932|Negativicutes 909932|Negativicutes L AAA domain - - - - - - - - - - - - AAA_25 k59_5606_1 8153.XP_005952986.1 3.07e-75 264.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BPSU@33208|Metazoa,3E41R@33213|Bilateria,48QRC@7711|Chordata,49MB3@7742|Vertebrata,4A94E@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_45712_2 1229909.NSED_01165 3.8e-44 150.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_7924_1 1485544.JQKP01000005_gene397 5.57e-19 88.2 COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,44W5T@713636|Nitrosomonadales 28216|Betaproteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C,FabA k59_12297_1 1163409.UUA_15171 5.24e-25 105.0 COG0843@1|root,COG0843@2|Bacteria,1QDZV@1224|Proteobacteria,1RYXY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM cytochrome c oxidase subunit I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_10168_1 1229909.NSED_00275 4.45e-47 163.0 COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota 651137|Thaumarchaeota S Radical SAM - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_10168_2 344747.PM8797T_21943 1.86e-18 84.3 COG0451@1|root,COG0451@2|Bacteria,2IYGP@203682|Planctomycetes 203682|Planctomycetes M PFAM NAD dependent epimerase dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_21260_1 1229909.NSED_09510 1.41e-99 297.0 COG1041@1|root,arCOG00047@2157|Archaea 2157|Archaea L RNA methylase trmG10 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 ko:K07446 - - - - ko00000,ko01000,ko03016 - - - THUMP,UPF0020 k59_61259_1 436308.Nmar_0451 4.99e-71 219.0 arCOG07871@1|root,arCOG07871@2157|Archaea,41T28@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1061 DNA or RNA helicases of superfamily II - - - - - - - - - - - - - k59_43555_1 1131266.ARWQ01000001_gene1390 1.12e-68 214.0 COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_43555_2 436308.Nmar_1753 4.05e-16 77.8 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_19117_1 47839.CCAU010000009_gene1461 2.21e-12 77.4 COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,23407@1762|Mycobacteriaceae 201174|Actinobacteria O assembly protein SufB sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K09014 - - - - ko00000 - - - UPF0051 k59_19117_2 1056830.G1FTU3_9CAUD 6.01e-10 66.2 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0003824,GO:0005575,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019012,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - - k59_70276_1 1165096.ARWF01000001_gene1419 3.35e-84 265.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKZR@206350|Nitrosomonadales 206350|Nitrosomonadales NU General secretory system II protein E domain protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_52335_1 497321.C664_19501 1.67e-31 116.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,2KWMU@206389|Rhodocyclales 206389|Rhodocyclales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_63158_1 448385.sce0725 5.06e-37 131.0 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,43B1P@68525|delta/epsilon subdivisions,2X6FU@28221|Deltaproteobacteria,2YUYE@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF1993) - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_20899_1 666681.M301_0638 3.73e-87 266.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,2KM9V@206350|Nitrosomonadales 206350|Nitrosomonadales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_45341_1 502025.Hoch_4901 0.000143 44.7 COG2885@1|root,COG2885@2|Bacteria,1NRFN@1224|Proteobacteria,43CZ4@68525|delta/epsilon subdivisions,2X87C@28221|Deltaproteobacteria 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_69886_1 1163617.SCD_n02208 5.06e-85 270.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_27592_1 1194972.MVAC_24091 6.99e-13 69.3 COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,23A2J@1762|Mycobacteriaceae 201174|Actinobacteria S protein involved in propionate catabolism - - - - - - - - - - - - MmgE_PrpD k59_27592_2 1205680.CAKO01000040_gene1099 2.61e-29 113.0 COG1028@1|root,COG1028@2|Bacteria,1MU32@1224|Proteobacteria,2TUYY@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_43180_1 1504672.669782992 5.51e-40 134.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,4AEZ7@80864|Comamonadaceae 28216|Betaproteobacteria J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_43180_2 1485544.JQKP01000001_gene1281 6.07e-21 91.7 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,44V5G@713636|Nitrosomonadales 28216|Betaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_9823_1 2340.JV46_05690 3.43e-106 317.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_32105_1 436308.Nmar_1725 5.31e-78 240.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_32105_2 1459636.NTE_02604 8.77e-09 56.2 COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the peptidase M24B family - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_25334_1 1415754.JQMK01000013_gene388 2.91e-56 186.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1S900@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_23,HTH_32 k59_9832_1 232721.Ajs_0393 5.73e-91 270.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,4A9NY@80864|Comamonadaceae 28216|Betaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_9832_2 1288494.EBAPG3_29930 6.36e-06 45.8 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,373HJ@32003|Nitrosomonadales 28216|Betaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_58786_1 1500257.JQNM01000011_gene5594 2.42e-83 258.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae 28211|Alphaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_5320_1 477228.YO5_11050 2.22e-11 67.8 COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria,1Z1FN@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria U Bacterial type II/III secretion system short domain - - - - - - - - - - - - Secretin,Secretin_N k59_20933_1 91464.S7335_3946 3.84e-20 84.3 COG0776@1|root,COG0776@2|Bacteria,1G7ER@1117|Cyanobacteria,1H0RE@1129|Synechococcus 1117|Cyanobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions himA - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_20933_2 640081.Dsui_1701 1.81e-22 92.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,2KW5S@206389|Rhodocyclales 206389|Rhodocyclales L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_43194_1 153948.NAL212_3114 9.94e-67 214.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,372PH@32003|Nitrosomonadales 28216|Betaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_49761_1 436308.Nmar_0476 1.08e-96 286.0 COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_49761_2 1229909.NSED_02395 4.29e-14 70.5 COG1131@1|root,arCOG00196@2157|Archaea,41S73@651137|Thaumarchaeota 651137|Thaumarchaeota V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_36525_1 1131266.ARWQ01000010_gene35 2.24e-08 60.8 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_65406_1 1187851.A33M_2605 2.39e-60 197.0 COG4177@1|root,COG4177@2|Bacteria,1PSHZ@1224|Proteobacteria,2TVQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_5323_1 436308.Nmar_0224 7.21e-45 156.0 COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the phosphohexose mutase family - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_5323_2 436308.Nmar_0225 3.85e-48 155.0 COG1358@1|root,arCOG01751@2157|Archaea,41SMS@651137|Thaumarchaeota 651137|Thaumarchaeota J Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs rpl7ae - - ko:K02936 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03009,ko03011 - - - Ribosomal_L7Ae k59_52004_1 7029.ACYPI49124-PA 2.4e-23 104.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,420TT@6656|Arthropoda,3SQFK@50557|Insecta,3EEB6@33342|Paraneoptera 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_9849_1 228410.NE1431 4.3e-85 263.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,3723P@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,S4_2,tRNA-synt_1b k59_16530_1 931627.MycrhDRAFT_1031 0.000277 45.4 COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria,234ZC@1762|Mycobacteriaceae 201174|Actinobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_16530_2 2340.JV46_29130 1.32e-73 223.0 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,1S4X5@1236|Gammaproteobacteria,1JAJM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_21104_1 436308.Nmar_1649 5.49e-81 247.0 arCOG10597@1|root,arCOG10597@2157|Archaea 2157|Archaea O serine-type endopeptidase activity - - - - - - - - - - - - - k59_36715_1 1229909.NSED_06830 6.73e-112 337.0 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_36717_1 745014.OMB55_00015480 7.46e-30 116.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1J4Y7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2485 M20_dimer,Peptidase_M20 k59_47610_1 7668.SPU_005035-tr 1.69e-66 235.0 KOG1721@1|root,KOG1721@2759|Eukaryota,38BZ9@33154|Opisthokonta,3BA9A@33208|Metazoa,3CT35@33213|Bilateria 33208|Metazoa C nucleic acid binding ZFP62 GO:0000981,GO:0003674,GO:0003700,GO:0006355,GO:0006357,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K09228 - - - - ko00000,ko03000 - - - KRAB,zf-C2H2,zf-C2H2_6 k59_63425_1 279303.Q6J7Y2_9CAUD 2.61e-107 320.0 4QCB0@10239|Viruses,4QX81@35237|dsDNA viruses no RNA stage,4QPFH@28883|Caudovirales,4QKQY@10699|Siphoviridae 10699|Siphoviridae S YqaJ-like viral recombinase domain - - - - - - - - - - - - - k59_14601_3 104355.XP_007870017.1 3.93e-18 88.6 COG0216@1|root,KOG2726@2759|Eukaryota,38CVW@33154|Opisthokonta,3NX8M@4751|Fungi,3UYSU@5204|Basidiomycota,224SS@155619|Agaricomycetes,3H3Q6@355688|Agaricomycetes incertae sedis 4751|Fungi J Release factor MRF1 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016149,GO:0019538,GO:0019866,GO:0022411,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032543,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070126,GO:0071704,GO:0071840,GO:0097159,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_70045_1 2880.D8LMH0 3.05e-16 83.6 COG0553@1|root,KOG1000@2759|Eukaryota 2759|Eukaryota L annealing helicase activity - - 3.6.4.12 ko:K14440 - - - - ko00000,ko01000,ko03036 - - - Helicase_C,SNF2_N k59_58951_1 1298867.AUES01000051_gene4511 2.88e-62 217.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_54476_1 257310.BB4343 1.38e-71 233.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,3T5UC@506|Alcaligenaceae 28216|Betaproteobacteria T PrkA AAA domain prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_38975_1 448385.sce1855 1.07e-49 167.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2WTV5@28221|Deltaproteobacteria,2YZNQ@29|Myxococcales 28221|Deltaproteobacteria C Protein of unknown function (DUF561) - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_70055_1 45130.XP_007705870.1 7.95e-17 83.6 2ARPT@1|root,2RZMU@2759|Eukaryota,3AFXZ@33154|Opisthokonta,3PARY@4751|Fungi,3R120@4890|Ascomycota 4751|Fungi - - - - - - - - - - - - - - - k59_3494_1 1229909.NSED_09500 1.41e-45 164.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_65537_1 1229909.NSED_01095 1.59e-77 237.0 COG1976@1|root,arCOG04176@2157|Archaea,41SIP@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex eif6 - - ko:K03264 ko03008,map03008 - - - ko00000,ko00001,ko03009,ko03012 - - - eIF-6 k59_58961_1 1122915.AUGY01000118_gene6532 2.93e-18 83.6 COG2223@1|root,COG2223@2|Bacteria 2|Bacteria P nitrite transmembrane transporter activity - - - ko:K02575,ko:K08223 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.35,2.A.1.8 - - MFS_1 k59_58961_2 1392838.AWNM01000085_gene1658 6.03e-16 78.6 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VJDM@28216|Betaproteobacteria,3T3A3@506|Alcaligenaceae 28216|Betaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_36729_1 436308.Nmar_1511 2.77e-131 384.0 COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_7789_1 196367.JNFG01000003_gene5665 7.25e-67 207.0 COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2VQMS@28216|Betaproteobacteria,1K8XM@119060|Burkholderiaceae 28216|Betaproteobacteria S Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_N k59_29943_1 3885.XP_007141246.1 4.81e-12 60.8 2D5CJ@1|root,2SY3I@2759|Eukaryota,38309@33090|Viridiplantae,3GS5N@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_21155_1 1454004.AW11_03381 1.33e-82 264.0 COG3386@1|root,COG3386@2|Bacteria,1QW76@1224|Proteobacteria 1224|Proteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_32332_2 666509.RCA23_c28380 1.37e-41 146.0 COG3181@1|root,COG3181@2|Bacteria,1R49H@1224|Proteobacteria,2U1IK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_61126_1 1229909.NSED_08360 2.4e-63 197.0 arCOG10589@1|root,arCOG10589@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_61126_2 1229909.NSED_08365 2.91e-43 144.0 arCOG08643@1|root,arCOG08643@2157|Archaea,41T5M@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_52207_2 1288494.EBAPG3_5330 1.59e-21 89.0 COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,37363@32003|Nitrosomonadales 28216|Betaproteobacteria T Phosphoglycerate mutase family sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_23344_1 864051.BurJ1DRAFT_2970 3.4e-43 153.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1KJ4Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Dehydrogenase odhL GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_65549_1 323848.Nmul_A1737 9.68e-27 107.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,372MP@32003|Nitrosomonadales 28216|Betaproteobacteria S Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_32344_1 1229909.NSED_01150 1.35e-103 306.0 COG0673@1|root,arCOG01622@2157|Archaea,41SZ6@651137|Thaumarchaeota 651137|Thaumarchaeota S Oxidoreductase family, NAD-binding Rossmann fold - - 1.1.1.374 ko:K18855 - - - - ko00000,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_16720_2 279714.FuraDRAFT_2524 8.83e-60 206.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_52215_1 543913.D521_0540 3.55e-87 271.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_58972_2 279303.Q6J816_9CAUD 6.25e-52 172.0 4QF9N@10239|Viruses,4QUNU@35237|dsDNA viruses no RNA stage,4QRT6@28883|Caudovirales,4QKQH@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_56704_1 8090.ENSORLP00000017069 2.55e-05 52.4 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49ADZ@7742|Vertebrata,4A4QB@7898|Actinopterygii 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_16725_1 1454004.AW11_03085 9.33e-100 310.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_39023_1 1122214.AQWH01000037_gene61 3.46e-12 68.6 COG3090@1|root,COG3090@2|Bacteria 2|Bacteria G Trap-type c4-dicarboxylate transport system, small permease component - - - ko:K11689,ko:K21394 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ k59_7815_1 1242864.D187_005925 7e-11 67.8 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_34683_1 436308.Nmar_0177 8.5e-113 333.0 COG0436@1|root,arCOG01131@2157|Archaea,41S8G@651137|Thaumarchaeota 651137|Thaumarchaeota E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 k59_26206_1 1229909.NSED_06530 2.05e-124 362.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_35511_1 244447.XP_008333619.1 4.16e-89 295.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_6251_1 1229909.NSED_07565 2.37e-108 318.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_70868_1 1547437.LL06_22675 6.81e-35 131.0 COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,43GT4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal k59_70871_1 436308.Nmar_0065 6.03e-108 318.0 COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota 651137|Thaumarchaeota L Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priL - - ko:K18882 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_lrg k59_39648_1 1229909.NSED_05300 6.29e-54 180.0 COG1378@1|root,arCOG02038@2157|Archaea 2157|Archaea K transcriptional - - - - - - - - - - - - Regulator_TrmB,TrmB k59_37489_1 1131266.ARWQ01000004_gene1483 4.7e-09 56.2 COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_24136_1 7897.ENSLACP00000016854 3.82e-57 209.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria,48QAV@7711|Chordata 33208|Metazoa S Ribonuclease H protein - - 2.3.1.15,2.4.2.29 ko:K13506,ko:K15407 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R03789,R09380,R10209 RC00004,RC00039,RC00041,RC00063 ko00000,ko00001,ko00002,ko01000,ko01004,ko03016 - - - Exo_endo_phos,Exo_endo_phos_2,RVT_1 k59_44164_1 438753.AZC_2902 4.54e-15 75.9 COG0583@1|root,COG0583@2|Bacteria,1RI7F@1224|Proteobacteria,2VFIP@28211|Alphaproteobacteria 28211|Alphaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_44164_2 522306.CAP2UW1_0197 1.65e-40 146.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2VNDQ@28216|Betaproteobacteria 28216|Betaproteobacteria P Arylsulfatase - - 3.1.6.1,3.1.6.6 ko:K01130,ko:K01133 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_33021_2 1399147.P618_200441 1.01e-18 84.7 COG3926@1|root,COG3926@2|Bacteria 2|Bacteria S Glycosyl hydrolase 108 - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Glyco_hydro_108,PG_binding_3 k59_33022_1 7668.SPU_009536-tr 2.24e-53 192.0 KOG1075@1|root,KOG3538@1|root,KOG1075@2759|Eukaryota,KOG3538@2759|Eukaryota,3APWC@33154|Opisthokonta,3C20X@33208|Metazoa 2759|Eukaryota O Reverse transcriptase (RNA-dependent DNA polymerase) - - - ko:K08625 - - - - ko00000,ko01000,ko01002 - - - ADAM_spacer1,EGF,Ephrin_rec_like,GON,HYR,Reprolysin,Reprolysin_5,Sushi,TSP_1,Xlink,hEGF k59_46349_1 267608.RSp1179 1.52e-95 288.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,1K3UX@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_50640_1 10224.XP_006825930.1 3.91e-39 150.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria 33208|Metazoa G positive regulation of TOR signaling - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_39665_1 1100720.ALKN01000035_gene996 3.26e-36 134.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VPJG@28216|Betaproteobacteria,4AA7X@80864|Comamonadaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_61934_1 1121035.AUCH01000008_gene1029 1.23e-68 231.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales 206389|Rhodocyclales L DNA topoisomerase III - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k59_48397_1 159749.E7BWK8 1.23e-100 320.0 COG0542@1|root,KOG1051@2759|Eukaryota,2XEW9@2836|Bacillariophyta 2836|Bacillariophyta O Belongs to the ClpA ClpB family - - - - - - - - - - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_64299_1 10224.XP_006825930.1 8.67e-57 202.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria 33208|Metazoa G positive regulation of TOR signaling - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_21935_1 279303.Q6J7X6_9CAUD 2.88e-68 231.0 4QAKM@10239|Viruses,4QZGT@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_61966_1 1033991.RLEG12_30420 1.07e-140 420.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,4B9N7@82115|Rhizobiaceae 28211|Alphaproteobacteria G Phosphoketolase xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_26258_1 1524467.IV04_20380 1.51e-26 108.0 COG0863@1|root,COG0863@2|Bacteria,1MY4G@1224|Proteobacteria,1RQHA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_44199_1 1266925.JHVX01000003_gene639 3.52e-69 216.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2VIU9@28216|Betaproteobacteria,372R8@32003|Nitrosomonadales 28216|Betaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_37556_1 557598.LHK_02562 2.58e-42 144.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,2KRC6@206351|Neisseriales 206351|Neisseriales M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_37556_2 1454004.AW11_01476 1.15e-07 50.8 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,2VU5Y@28216|Betaproteobacteria,1KQTJ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_57542_1 1458275.AZ34_16780 5.32e-40 147.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,4A9ZQ@80864|Comamonadaceae 28216|Betaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_70909_1 1298867.AUES01000051_gene4511 3.77e-52 188.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_52991_1 436308.Nmar_1727 6.84e-225 633.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL k59_39731_1 1123073.KB899241_gene2078 1.78e-68 221.0 COG1232@1|root,COG1232@2|Bacteria,1P80H@1224|Proteobacteria,1S0R5@1236|Gammaproteobacteria,1X5SI@135614|Xanthomonadales 135614|Xanthomonadales H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_53007_1 1389489.O159_28170 1.87e-37 134.0 COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4FNHF@85023|Microbacteriaceae 201174|Actinobacteria L insertion element ISCmi2 transposase - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - HTH_23,LZ_Tnp_IS481,rve,rve_3 k59_70919_1 1298867.AUES01000051_gene4511 2.06e-12 73.9 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_24219_2 196490.AUEZ01000025_gene2249 9.62e-09 58.9 COG3181@1|root,COG3181@2|Bacteria,1P25R@1224|Proteobacteria,2U52X@28211|Alphaproteobacteria,3K3AN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_39735_1 391038.Bphy_4960 3.42e-167 480.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,1K2CQ@119060|Burkholderiaceae 28216|Betaproteobacteria L Elements of external origin - - - - - - - - - - - - DDE_5 k59_57570_1 1540090.A0A0A0RS07_9CAUD 2.78e-13 68.2 4QEXJ@10239|Viruses,4QUG9@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_21975_1 983917.RGE_23590 3.66e-07 55.1 COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria,1KKFE@119065|unclassified Burkholderiales 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_30779_1 1123313.ATUT01000009_gene1705 6.72e-07 49.3 COG0234@1|root,COG0234@2|Bacteria,1TU33@1239|Firmicutes,3VRPD@526524|Erysipelotrichia 526524|Erysipelotrichia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - - - - - - - - - - Cpn10 k59_37588_2 279303.Q6J7X8_9CAUD 5.67e-21 92.4 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_68680_1 525897.Dbac_0859 1.2e-27 107.0 COG3639@1|root,COG3639@2|Bacteria,1MUD6@1224|Proteobacteria,42S1A@68525|delta/epsilon subdivisions,2WKMD@28221|Deltaproteobacteria,2MAD6@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM phosphonate ABC transporter, inner membrane subunit - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_68680_2 1123504.JQKD01000018_gene2043 2.73e-69 217.0 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2VM8M@28216|Betaproteobacteria,4AJ6I@80864|Comamonadaceae 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component phnE_2 - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_24235_1 279303.Q6J827_9CAUD 1.76e-46 165.0 4QBSP@10239|Viruses,4QZ8J@35237|dsDNA viruses no RNA stage,4QRAT@28883|Caudovirales,4QM0N@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_48460_2 1304878.AUGD01000009_gene6393 1.75e-19 83.2 2EMVQ@1|root,33FHY@2|Bacteria,1NNSC@1224|Proteobacteria,2UWDN@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_26308_1 7897.ENSLACP00000022006 2.25e-18 85.5 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49ADZ@7742|Vertebrata 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_55220_1 1288298.rosmuc_01089 2.99e-40 139.0 COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,2UBRM@28211|Alphaproteobacteria,46QHE@74030|Roseovarius 28211|Alphaproteobacteria S YHS domain - - - - - - - - - - - - YHS k59_64367_1 1125973.JNLC01000018_gene2320 2.63e-115 347.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - - - - - - - - - - TctA k59_64369_1 85643.Tmz1t_1497 3.25e-94 294.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_59761_1 7897.ENSLACP00000017255 1.47e-33 132.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_18345_2 46429.BV95_01892 6.38e-51 174.0 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2TSS4@28211|Alphaproteobacteria,2K2SC@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the mandelate racemase muconate lactonizing enzyme family - - 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_62778_1 457398.HMPREF0326_01805 3.65e-19 92.8 COG0354@1|root,COG2931@1|root,COG0354@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PPF@68525|delta/epsilon subdivisions,2WM3K@28221|Deltaproteobacteria,2MG5Z@213115|Desulfovibrionales 28221|Deltaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_22747_1 765912.Thimo_0459 2.85e-71 228.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales 135613|Chromatiales L reverse transcriptase - - - - - - - - - - - - RVT_1 k59_53811_1 1254432.SCE1572_46360 3.5e-68 225.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,43CJE@68525|delta/epsilon subdivisions,2X7TT@28221|Deltaproteobacteria,2Z3N4@29|Myxococcales 28221|Deltaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_47174_1 1229909.NSED_07585 3.31e-56 194.0 arCOG08705@1|root,arCOG08705@2157|Archaea,41SXV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_51604_1 436308.Nmar_0473 3.1e-31 111.0 arCOG07802@1|root,arCOG07802@2157|Archaea,41T6C@651137|Thaumarchaeota 651137|Thaumarchaeota S Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red k59_51604_2 436308.Nmar_0474 1.37e-52 167.0 arCOG08735@1|root,arCOG08735@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_57185_1 640081.Dsui_2785 4.35e-57 199.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,2KUX1@206389|Rhodocyclales 206389|Rhodocyclales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_28233_2 272558.10174344 5.95e-07 50.8 COG3332@1|root,COG3332@2|Bacteria,1UYHE@1239|Firmicutes,4HCA1@91061|Bacilli,1ZCCC@1386|Bacillus 91061|Bacilli S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_54897_1 1229909.NSED_01680 9.2e-07 47.0 COG1958@1|root,arCOG00998@2157|Archaea 2157|Archaea K Like-Sm ribonucleoprotein core lsm GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K04796 - - - - ko00000 - - - LSM k59_30436_1 930169.B5T_01028 1.68e-17 85.5 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,1RPHN@1236|Gammaproteobacteria,1XH7H@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional regulator, LysR - - - - - - - - - - - - HTH_1,LysR_substrate k59_46078_2 1150864.MILUP08_45742 6.53e-20 94.4 2DRCF@1|root,33B7F@2|Bacteria,2GM2S@201174|Actinobacteria,4DGWA@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_57189_1 1175306.GWL_23560 4.63e-10 58.2 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2VQFV@28216|Betaproteobacteria,474FZ@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_57189_2 1163617.SCD_n02353 1.67e-28 107.0 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,2VW2I@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_19377_1 10224.XP_006825930.1 7.09e-50 181.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria 33208|Metazoa G positive regulation of TOR signaling - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_61572_1 882378.RBRH_01757 8.39e-69 224.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,1K0QI@119060|Burkholderiaceae 28216|Betaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_61572_2 1235457.C404_18540 4.73e-05 45.1 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae 28216|Betaproteobacteria C Malic enzyme maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_57196_1 698761.RTCIAT899_CH14445 1.07e-74 226.0 COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,2TUQI@28211|Alphaproteobacteria,4BFD5@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_57196_2 883078.HMPREF9695_04457 4.94e-20 83.6 COG3293@1|root,COG3293@2|Bacteria,1RM2E@1224|Proteobacteria,2U8WG@28211|Alphaproteobacteria,3K60I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - ko:K07492 - - - - ko00000 - - - DUF4096 k59_32760_2 1229909.NSED_08175 2.12e-120 344.0 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_70612_1 436308.Nmar_0651 3.6e-102 326.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_10488_1 365046.Rta_17960 1.54e-10 64.3 COG1846@1|root,COG1846@2|Bacteria,1RJPG@1224|Proteobacteria,2VT4F@28216|Betaproteobacteria,4AEIR@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_12633_1 1229909.NSED_03095 8.37e-103 309.0 COG1060@1|root,arCOG00656@2157|Archaea,41SDT@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11781 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_35261_1 436308.Nmar_1793 7.48e-119 350.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_68355_1 1229909.NSED_02485 2.21e-90 277.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 k59_41606_1 67315.JOBD01000001_gene1040 2.42e-24 106.0 COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE25_2 - - ko:K00257 - - R04547,R04592 RC01942 ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_68356_1 1229909.NSED_01570 2.02e-73 226.0 COG0099@1|root,arCOG01722@2157|Archaea,41SIW@651137|Thaumarchaeota 651137|Thaumarchaeota J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rps13 - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_37263_1 1229909.NSED_02310 8.61e-06 47.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_37263_2 1131266.ARWQ01000010_gene43 1.14e-44 150.0 arCOG08731@1|root,arCOG08731@2157|Archaea,41STT@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_19400_1 745310.G432_12710 2.09e-10 66.2 COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,2K14M@204457|Sphingomonadales 204457|Sphingomonadales S CYTH - - - - - - - - - - - - CHAD,CYTH k59_43864_1 1144307.PMI04_03192 6.45e-12 70.5 COG0346@1|root,COG0346@2|Bacteria,1MUBT@1224|Proteobacteria,2VG68@28211|Alphaproteobacteria,2K1BM@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_19403_1 13735.ENSPSIP00000001057 1.86e-143 432.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BHR3@33208|Metazoa,3CUIP@33213|Bilateria,48DAM@7711|Chordata,49HS5@7742|Vertebrata,4CMNI@8459|Testudines 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_12644_1 580332.Slit_0145 7.8e-69 222.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,44UYU@713636|Nitrosomonadales 28216|Betaproteobacteria J S-adenosylmethionine-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_52652_1 1459636.NTE_02907 1.15e-131 382.0 COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_52654_1 436308.Nmar_1083 6e-25 95.1 COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_52654_2 436308.Nmar_1082 8.71e-33 115.0 arCOG10573@1|root,arCOG10573@2157|Archaea,41T8W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_52654_3 1229909.NSED_06295 2.73e-28 103.0 arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_17212_1 436308.Nmar_0011 4.53e-165 480.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_5978_1 1131266.ARWQ01000001_gene1319 2.25e-109 320.0 COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota 651137|Thaumarchaeota E Phosphoadenosine phosphosulfate reductase family - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_35292_1 5145.XP_001903703.1 2.51e-05 53.5 COG0666@1|root,KOG4177@2759|Eukaryota,3A67M@33154|Opisthokonta,3P67D@4751|Fungi,3QSH4@4890|Ascomycota,21862@147550|Sordariomycetes,3UBI3@5139|Sordariales 4751|Fungi M Ankyrin repeat - - - - - - - - - - - - Ank,Ank_2,Ank_4 k59_61635_1 1131266.ARWQ01000029_gene981 1.43e-28 112.0 arCOG08793@1|root,arCOG08793@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_59436_1 1131553.JIBI01000010_gene1362 3.29e-111 341.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,374MC@32003|Nitrosomonadales 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_8263_1 1454004.AW11_00092 7.8e-116 343.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1KQA3@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_8274_1 948071.S4S2S9_9CAUD 2.63e-08 59.7 4QBYN@10239|Viruses,4QZT8@35237|dsDNA viruses no RNA stage,4QR5G@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_10543_1 583345.Mmol_0339 6.02e-42 154.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,2KMFS@206350|Nitrosomonadales 206350|Nitrosomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_15128_1 864069.MicloDRAFT_00003420 4.05e-10 62.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JW30@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_43901_1 1123228.AUIH01000001_gene1290 2.98e-22 96.3 arCOG14225@1|root,2ZC7S@2|Bacteria,1RA98@1224|Proteobacteria,1SVT0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_19445_1 1229909.NSED_08890 3.33e-146 419.0 COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_39448_1 1229909.NSED_02275 1.25e-53 171.0 COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PIN domain of ribonuclease - - - ko:K07060 - - - - ko00000,ko01000,ko02048 - - - PIN_6 k59_39448_2 436308.Nmar_0437 3.03e-24 97.1 COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota 651137|Thaumarchaeota L ERCC4 domain - - - ko:K10848 ko03420,ko03460,map03420,map03460 - - - ko00000,ko00001,ko01000,ko03032,ko03400 - - - ERCC4,HHH_5 k59_50475_1 1229909.NSED_03430 2.73e-144 423.0 COG0155@1|root,arCOG02055@2157|Archaea,41S5Q@651137|Thaumarchaeota 651137|Thaumarchaeota C Sulfite reductase - - 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_52688_1 1177181.T9A_00554 2.53e-27 101.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1XKYU@135619|Oceanospirillales 135619|Oceanospirillales S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_23938_1 555779.Dthio_PD3704 8.25e-52 180.0 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_57300_1 1229909.NSED_09080 1.6e-79 248.0 COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD k59_48206_1 1116472.MGMO_109c00050 1.04e-18 84.7 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1XE5B@135618|Methylococcales 1236|Gammaproteobacteria E PFAM Aminotransferase, class I ybdL - 2.6.1.88 ko:K14287 - - R08618 RC00006,RC00025 ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_8322_1 436308.Nmar_0359 1.02e-10 61.2 COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - Trp_halogenase k59_28333_1 1229909.NSED_02355 1.95e-17 81.3 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_28333_2 1229909.NSED_02360 2.62e-56 177.0 COG0457@1|root,arCOG03032@2157|Archaea,41T5X@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_59508_1 1131266.ARWQ01000008_gene298 3.95e-26 107.0 COG0673@1|root,COG1241@1|root,arCOG00439@2157|Archaea,arCOG01622@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_59508_2 436308.Nmar_0246 2.7e-41 137.0 COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota 651137|Thaumarchaeota S Trm112p-like protein - - - - - - - - - - - - Trm112p k59_59508_3 1229909.NSED_01140 2.2e-12 65.9 COG0110@1|root,arCOG01848@2157|Archaea,41SJ0@651137|Thaumarchaeota 651137|Thaumarchaeota S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep k59_70700_1 1229909.NSED_09375 1.73e-93 280.0 COG1721@1|root,arCOG02745@2157|Archaea 2157|Archaea S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_70700_2 1229909.NSED_09370 3.58e-13 68.2 COG2304@1|root,arCOG02902@2157|Archaea 2157|Archaea O von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_65993_1 887062.HGR_09523 2.54e-15 73.6 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,4AEEQ@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM thioesterase superfamily protein ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_65993_2 640081.Dsui_0482 2.4e-35 127.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,2KV8T@206389|Rhodocyclales 206389|Rhodocyclales U MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_68451_1 436308.Nmar_0214 4.65e-79 249.0 COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_66169_1 1242864.D187_006660 1.59e-105 315.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_35492_1 365046.Rta_15490 3.72e-64 206.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria 28216|Betaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - 4.1.1.3,5.4.2.9 ko:K01003,ko:K01841 ko00440,ko00620,ko01100,ko01120,ko01130,map00440,map00620,map01100,map01120,map01130 - R00217,R00661 RC00040,RC02792 ko00000,ko00001,ko01000 - - - PEP_mutase k59_39633_1 1123230.ARQJ01000001_gene1096 2.65e-15 71.2 arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,4HFPA@91061|Bacilli,4GZG2@90964|Staphylococcaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_39633_2 113355.CM001775_gene3188 2.51e-29 105.0 2DNQR@1|root,32YKU@2|Bacteria,1G9K3@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_70514_1 1229909.NSED_00170 2.42e-65 209.0 COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota 651137|Thaumarchaeota M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - - - - - - - - - - - k59_5851_1 290397.Adeh_0640 1.61e-08 54.7 COG1396@1|root,COG1396@2|Bacteria,1QYFR@1224|Proteobacteria,43CBW@68525|delta/epsilon subdivisions,2X7MR@28221|Deltaproteobacteria,2Z2CU@29|Myxococcales 28221|Deltaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_5851_2 402626.Rpic_2351 1.5e-20 85.1 2DTKS@1|root,33KSY@2|Bacteria,1NN6H@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_30337_1 228410.NE0106 1.43e-65 213.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria,371SA@32003|Nitrosomonadales 28216|Betaproteobacteria Q Permease MlaE mlaE_2 - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_70516_1 1005048.CFU_0401 2.16e-21 90.1 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,472AC@75682|Oxalobacteraceae 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_70516_2 1218076.BAYB01000028_gene4736 1.61e-59 185.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2VSDQ@28216|Betaproteobacteria,1K7MU@119060|Burkholderiaceae 28216|Betaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_35138_1 261292.Nit79A3_0139 2.29e-82 258.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,372CM@32003|Nitrosomonadales 28216|Betaproteobacteria P Domain of unknown function DUF21 corB - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_19319_1 994479.GL877878_gene1024 9.89e-09 58.5 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_50341_1 580332.Slit_1733 2.54e-42 147.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,44VDW@713636|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_50341_2 522306.CAP2UW1_1214 1.11e-30 122.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1KPNC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_48017_1 1123392.AQWL01000005_gene3134 1.15e-37 139.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2VMTN@28216|Betaproteobacteria,1KS9H@119069|Hydrogenophilales 119069|Hydrogenophilales F Metalloenzyme superfamily - - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_48017_2 1123393.KB891316_gene1726 0.000215 42.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2VU9V@28216|Betaproteobacteria,1KT6W@119069|Hydrogenophilales 119069|Hydrogenophilales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 k59_59354_1 7029.ACYPI073473-PA 0.000634 43.5 2EA4H@1|root,2SZ18@2759|Eukaryota,38VIS@33154|Opisthokonta,3C5X1@33208|Metazoa,3DR66@33213|Bilateria,428IV@6656|Arthropoda,3SSBM@50557|Insecta 7029.ACYPI073473-PA|- - - - - - - - - - - - - - - - k59_8122_1 1169154.KB897776_gene1871 4.38e-07 56.2 COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria 201174|Actinobacteria M 3-beta hydroxysteroid dehydrogenase isomerase - - - ko:K21793 ko00333,ko01130,map00333,map01130 M00838 R11663,R11666 - ko00000,ko00001,ko00002 - - - Epimerase k59_68278_1 1131266.ARWQ01000014_gene86 2.66e-22 94.0 COG0074@1|root,arCOG01339@2157|Archaea,41SEU@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_68278_2 1131266.ARWQ01000014_gene85 1.78e-39 141.0 COG0045@1|root,arCOG01337@2157|Archaea,41S5M@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP-grasp domain - - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_41533_2 436308.Nmar_0413 5.2e-119 359.0 COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota 651137|Thaumarchaeota C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_70550_1 1031711.RSPO_c01434 4.12e-25 104.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,1K4ZW@119060|Burkholderiaceae 28216|Betaproteobacteria S 2-methylcitrate dehydratase prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_70550_2 1127695.HMPREF9163_01733 3.42e-17 79.3 28PR6@1|root,2ZCD4@2|Bacteria,1V1KT@1239|Firmicutes,4H6PD@909932|Negativicutes 909932|Negativicutes - - - - - - - - - - - - - - - k59_17102_1 114615.BRADO6608 1.99e-68 220.0 COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,3JXT1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_5884_1 1459636.NTE_02664 3.47e-09 63.5 COG1409@1|root,arCOG06534@1|root,arCOG07781@1|root,arCOG09729@1|root,arCOG06534@2157|Archaea,arCOG07781@2157|Archaea,arCOG09729@2157|Archaea,arCOG11020@2157|Archaea 2157|Archaea S cell adhesion involved in biofilm formation - - - - - - - - - - - - Big_1,CHB_HEX_C_1,He_PIG,PKD,Polysacc_deac_1 k59_8150_1 6087.XP_004212340.1 2.08e-13 75.1 2CTY1@1|root,2RI7I@2759|Eukaryota,3A3U7@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - - k59_23782_1 522306.CAP2UW1_3214 1.85e-110 328.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria 28216|Betaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_15036_1 1123024.AUII01000006_gene4644 2.87e-53 181.0 COG0654@1|root,COG0654@2|Bacteria,2GNA8@201174|Actinobacteria,4E77N@85010|Pseudonocardiales 201174|Actinobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - 1.14.13.10 ko:K19189 ko00760,ko01120,map00760,map01120 - R04130 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3,NAD_binding_8 k59_63912_1 1297570.MESS4_670041 7.95e-160 461.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_10431_1 1163617.SCD_n02352 2.99e-36 130.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria 28216|Betaproteobacteria L Belongs to the DnaA family hda - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_10431_2 1163617.SCD_n02225 1.99e-45 152.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria 28216|Betaproteobacteria E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_65872_1 1168059.KB899087_gene847 6e-37 138.0 COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria,3F2C8@335928|Xanthobacteraceae 28211|Alphaproteobacteria T Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HATPase_c_2,Response_reg,SpoIIE k59_52592_1 1380394.JADL01000012_gene803 1.58e-10 69.3 COG1376@1|root,COG2706@1|root,COG3209@1|root,COG5184@1|root,COG1376@2|Bacteria,COG2706@2|Bacteria,COG3209@2|Bacteria,COG5184@2|Bacteria,1QW4H@1224|Proteobacteria,2TX0D@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Rhs Family - - - - - - - - - - - - - k59_1678_1 436308.Nmar_1792 1.3e-79 254.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_8176_1 1192034.CAP_7630 3.14e-09 66.2 COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria,2YY0K@29|Myxococcales 28221|Deltaproteobacteria DZ Putative metal-binding motif - - - - - - - - - - - - Cu-binding_MopE,RCC1 k59_25910_1 977880.pRALTA_0296 3.71e-47 167.0 COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,2VMZS@28216|Betaproteobacteria,1K35W@119060|Burkholderiaceae 28216|Betaproteobacteria L Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - rve k59_5904_1 1038869.AXAN01000002_gene153 1.42e-28 110.0 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,1K7Q4@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM Rhodanese domain protein glpE - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_43819_1 748727.CLJU_c00400 2.61e-05 55.1 COG3953@1|root,COG5283@1|root,COG3953@2|Bacteria,COG5283@2|Bacteria,1VAT4@1239|Firmicutes,24H6B@186801|Clostridia,36IGP@31979|Clostridiaceae 186801|Clostridia D Transglycosylase SLT domain - - - - - - - - - - - - PhageMin_Tail,SLT k59_32733_1 882378.RBRH_01230 2.27e-67 208.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2VR2H@28216|Betaproteobacteria,1K79Y@119060|Burkholderiaceae 28216|Betaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_59381_1 1229909.NSED_09615 1.2e-80 244.0 COG1646@1|root,arCOG01085@2157|Archaea,41SH4@651137|Thaumarchaeota 651137|Thaumarchaeota H Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids - - 2.5.1.41 ko:K17104 ko00564,map00564 - R04158 RC01091 ko00000,ko00001,ko01000 - - - PcrB k59_59381_2 436308.Nmar_1794 1.53e-22 95.9 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_3925_1 470704.XP_007757246.1 5.58e-19 90.5 2CDPA@1|root,2S29V@2759|Eukaryota,39WU4@33154|Opisthokonta,3NYYA@4751|Fungi,3QJS5@4890|Ascomycota,20DVN@147545|Eurotiomycetes,3MVHK@451870|Chaetothyriomycetidae 4751|Fungi S Alpha/beta hydrolase of unknown function (DUF1100) - - - - - - - - - - - - DUF1100 k59_10439_1 228410.NE2049 3.33e-44 150.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2VHDK@28216|Betaproteobacteria,371RB@32003|Nitrosomonadales 28216|Betaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_28342_1 436308.Nmar_0871 1.51e-107 321.0 COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota 651137|Thaumarchaeota J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) - - 6.1.1.23 ko:K09759 ko00970,map00970 M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_30580_1 436308.Nmar_1201 1.05e-18 91.3 arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_57332_1 999541.bgla_1g04380 8.96e-63 198.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,1K1WK@119060|Burkholderiaceae 28216|Betaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_48233_1 1286093.C266_18201 3.54e-100 303.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,1K1DC@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_57335_1 391616.OA238_c46860 5.06e-59 198.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_28367_1 1502851.FG93_00150 5.25e-177 499.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_4052_1 1131553.JIBI01000012_gene782 9.46e-79 243.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,372HG@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_4052_2 402626.Rpic_3270 3.56e-12 62.4 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2VR6I@28216|Betaproteobacteria,1K711@119060|Burkholderiaceae 28216|Betaproteobacteria J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_21761_2 265072.Mfla_2506 1.52e-49 162.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,2VU7S@28216|Betaproteobacteria,2KMRM@206350|Nitrosomonadales 206350|Nitrosomonadales FG PFAM histidine triad (HIT) protein - - - - - - - - - - - - HIT k59_10631_1 1229909.NSED_06270 1.05e-203 576.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_19517_1 1229909.NSED_07555 6.41e-173 495.0 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_10641_1 450851.PHZ_c3360 2.49e-62 207.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2KFGN@204458|Caulobacterales 204458|Caulobacterales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_57351_1 35841.BT1A1_0851 5.93e-15 80.9 COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,4HDFR@91061|Bacilli 91061|Bacilli L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_61761_1 7668.SPU_025385-tr 1.95e-29 128.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa 33208|Metazoa OU K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2 k59_1832_1 864051.BurJ1DRAFT_3207 1.75e-24 109.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1837_2 265072.Mfla_2742 3.55e-34 130.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KMGD@206350|Nitrosomonadales 206350|Nitrosomonadales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_55029_1 436308.Nmar_1179 7.67e-59 196.0 arCOG08686@1|root,arCOG08686@2157|Archaea,41T56@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_32904_1 338963.Pcar_1256 4.03e-60 196.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales 28221|Deltaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA,GFO_IDH_MocA_C k59_61767_1 1229909.NSED_08180 1.81e-48 154.0 COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_61767_2 1229909.NSED_08185 7.71e-33 116.0 COG2947@1|root,arCOG08640@2157|Archaea,41SK6@651137|Thaumarchaeota 651137|Thaumarchaeota S EVE domain - - - - - - - - - - - - EVE k59_48261_1 396588.Tgr7_2163 2.93e-40 148.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria,1X258@135613|Chromatiales 135613|Chromatiales P von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_57385_1 375286.mma_0444 4.84e-34 123.0 COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2VTZ3@28216|Betaproteobacteria,474RQ@75682|Oxalobacteraceae 28216|Betaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_70774_1 667015.Bacsa_1644 1.06e-58 197.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,2FM3F@200643|Bacteroidia,4AMJG@815|Bacteroidaceae 976|Bacteroidetes M Psort location CytoplasmicMembrane, score 10.00 algI - - - - - - - - - - - MBOAT k59_55064_1 266265.Bxe_B2353 1.51e-91 283.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VQCJ@28216|Betaproteobacteria,1K1CQ@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the UbiD family - - - - - - - - - - - - UbiD k59_48267_1 1229909.NSED_00390 6.83e-65 199.0 COG1622@1|root,arCOG01236@2157|Archaea,41SMY@651137|Thaumarchaeota 651137|Thaumarchaeota C Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_48267_2 436308.Nmar_0182 1.35e-41 137.0 arCOG08824@1|root,arCOG08824@2157|Archaea,41SW7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_52349_1 391613.RTM1035_09833 4.04e-97 301.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_32459_1 1101190.ARWB01000001_gene2114 1.61e-12 66.6 COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2TQXG@28211|Alphaproteobacteria,370Y4@31993|Methylocystaceae 28211|Alphaproteobacteria T Crp-like helix-turn-helix domain MA20_25280 - - - - - - - - - - - HTH_Crp_2 k59_32459_2 1268068.PG5_32960 5.79e-11 65.1 COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria K PFAM Cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_30121_1 1042375.AFPL01000036_gene3074 3.89e-56 185.0 COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,1RMVI@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_16858_1 7668.SPU_002135-tr 4.69e-66 225.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BSEH@33208|Metazoa,3D91U@33213|Bilateria 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_70299_1 436308.Nmar_0382 2.15e-101 297.0 COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds directly to 23S rRNA. Probably involved in E site tRNA release rpl1 - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_14769_1 7668.SPU_008426-tr 2.14e-33 134.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_47813_1 1301098.PKB_3350 3e-47 167.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1022 Long-chain acyl-CoA synthetases (AMP-forming) - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_16886_1 1089552.KI911559_gene2275 6.78e-07 51.2 COG0559@1|root,COG0559@2|Bacteria,1R23K@1224|Proteobacteria,2TV24@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_16886_2 488538.SAR116_1460 4.35e-28 112.0 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system permease - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_23561_1 257310.BB1925 2.19e-168 481.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2VI7S@28216|Betaproteobacteria,3T1HH@506|Alcaligenaceae 28216|Betaproteobacteria E Aminotransferase alaC - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_27932_2 76114.ebA6730 2.44e-22 94.4 2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2W0ZB@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_5690_1 436308.Nmar_0299 1.16e-119 357.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_1435_1 765914.ThisiDRAFT_1399 1.8e-126 374.0 COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1WW4Z@135613|Chromatiales 135613|Chromatiales K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_45778_1 8153.XP_005932374.1 1.36e-45 167.0 2CUDF@1|root,2RKUU@2759|Eukaryota,39ZS3@33154|Opisthokonta,3BMPV@33208|Metazoa,3D5Y9@33213|Bilateria,48BX8@7711|Chordata,49A8X@7742|Vertebrata,4A5Z8@7898|Actinopterygii 33208|Metazoa S DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_Tnp_Tc3_2 k59_32495_1 497964.CfE428DRAFT_4402 1.77e-36 140.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,46VJY@74201|Verrucomicrobia 74201|Verrucomicrobia T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HATPase_c,HisKA,PAS_3 k59_1448_1 1229909.NSED_07440 6.38e-57 191.0 COG1196@1|root,arCOG10350@1|root,arCOG00371@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_23585_1 1229909.NSED_07100 1.27e-104 325.0 COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota 651137|Thaumarchaeota E Methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind k59_41407_1 1502852.FG94_03301 1.95e-32 120.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,4729R@75682|Oxalobacteraceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_41407_2 323848.Nmul_A0474 1.98e-37 138.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales 28216|Betaproteobacteria H TIGRFAM Acetolactate synthase, large subunit, biosynthetic ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_30184_1 76114.ebA3494 9.16e-40 139.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2VPCK@28216|Betaproteobacteria,2KVFX@206389|Rhodocyclales 206389|Rhodocyclales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_30184_2 557598.LHK_00457 3.67e-14 66.2 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2VVUH@28216|Betaproteobacteria,2KRNQ@206351|Neisseriales 206351|Neisseriales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_3697_1 1123060.JONP01000015_gene4343 5.4e-46 160.0 COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2VFQZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_16907_1 580332.Slit_2681 1.16e-41 155.0 COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,2WGMC@28216|Betaproteobacteria,44V6B@713636|Nitrosomonadales 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_68106_1 983917.RGE_46470 2.48e-23 95.9 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,2VVSJ@28216|Betaproteobacteria,1KMGT@119065|unclassified Burkholderiales 28216|Betaproteobacteria NU Belongs to the N-Me-Phe pilin family pilA - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_50145_1 640081.Dsui_3144 5.03e-47 161.0 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,2KW79@206389|Rhodocyclales 206389|Rhodocyclales NU type 4 pilus biogenesis protein pilF - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_16,TPR_2,TPR_8 k59_19198_1 555778.Hneap_0412 1.09e-125 372.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1X26N@135613|Chromatiales 135613|Chromatiales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_5714_1 159087.Daro_0629 4.61e-86 262.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,2KVGB@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_50155_1 1229909.NSED_06285 9.08e-18 81.3 COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota 651137|Thaumarchaeota C Glucose dehydrogenase C-terminus - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_50155_2 1229909.NSED_06290 1.13e-54 173.0 COG1436@1|root,arCOG04102@2157|Archaea,41T76@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (F/14-kDa) subunit - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F k59_34943_2 1121015.N789_09765 1.56e-14 74.7 COG0642@1|root,COG0642@2|Bacteria,1R514@1224|Proteobacteria,1T1KV@1236|Gammaproteobacteria,1X3D5@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase colS - - - - - - - - - - - HATPase_c,HisKA k59_34948_2 1122212.AULO01000009_gene674 5.9e-14 71.6 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XKPZ@135619|Oceanospirillales 135619|Oceanospirillales C cytochrome c5 - - - - - - - - - - - - Cytochrome_CBB3 k59_34948_3 1279017.AQYJ01000024_gene1129 2.65e-07 50.4 COG0840@1|root,COG0840@2|Bacteria,1RCTF@1224|Proteobacteria,1S317@1236|Gammaproteobacteria,466YK@72275|Alteromonadaceae 1236|Gammaproteobacteria NT Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_1468_1 598467.BrE312_4087 5.04e-51 170.0 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RQB6@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_1468_2 1216976.AX27061_4373 5.1e-30 113.0 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2VK8V@28216|Betaproteobacteria,3T20V@506|Alcaligenaceae 28216|Betaproteobacteria I Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit gctA - 2.8.3.12,2.8.3.5 ko:K01028,ko:K01039 ko00072,ko00280,ko00643,ko00650,ko01120,map00072,map00280,map00643,map00650,map01120 - R00410,R04000,R05509 RC00012,RC00014,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_34961_1 1229909.NSED_06950 5.19e-107 314.0 COG1712@1|root,arCOG00254@2157|Archaea,41SGA@651137|Thaumarchaeota 651137|Thaumarchaeota H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21 ko:K06989 ko00760,ko01100,map00760,map01100 - R07407,R07410 RC02566 ko00000,ko00001,ko01000 - - - DUF108,NAD_binding_3 k59_8002_1 1229909.NSED_03125 7.02e-48 155.0 COG0073@1|root,arCOG01136@2157|Archaea,41SSY@651137|Thaumarchaeota 651137|Thaumarchaeota J Putative tRNA binding domain - - - ko:K06878 - - - - ko00000 - - - tRNA_bind k59_50182_1 8049.ENSGMOP00000003306 2.9e-08 57.8 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49ADZ@7742|Vertebrata,4A4QB@7898|Actinopterygii 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_10294_1 436308.Nmar_0701 3.16e-85 270.0 COG0365@1|root,arCOG04201@2157|Archaea 2157|Archaea I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_30216_1 436308.Nmar_1426 1.37e-51 163.0 COG3432@1|root,arCOG01055@2157|Archaea,41SUJ@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_19220_1 1502770.JQMG01000001_gene437 3.31e-81 257.0 COG0548@1|root,COG1246@1|root,COG1396@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,COG1396@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KKM3@206350|Nitrosomonadales 206350|Nitrosomonadales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1,HTH_31 k59_39206_1 266264.Rmet_0375 1.12e-84 265.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,1K5EX@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K14392 - - - - ko00000,ko02000 2.A.21.1 - - SSF k59_54726_1 1229909.NSED_01325 7.33e-126 377.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_21408_1 436308.Nmar_1319 1.31e-115 335.0 COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA methylase - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_21408_2 436308.Nmar_1318 3.12e-53 169.0 COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota 651137|Thaumarchaeota U mttA/Hcf106 family - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_68130_1 977880.RALTA_A0002 4.9e-28 110.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,1K1D0@119060|Burkholderiaceae 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_39213_1 936455.KI421499_gene689 3.08e-95 293.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JWSI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Phosphoglucose isomerase pgi GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_5743_1 477228.YO5_10030 3.42e-36 137.0 COG0477@1|root,COG2814@2|Bacteria,1MUXC@1224|Proteobacteria,1RYAP@1236|Gammaproteobacteria,1Z276@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_35003_1 1005048.CFU_4232 2.78e-87 273.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,4730P@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_56967_1 1229909.NSED_07545 1.43e-115 340.0 COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules radA - - ko:K04483 - - - - ko00000,ko03400 - - - HHH_5,Rad51 k59_35008_1 13690.CP98_05380 1.15e-48 158.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,2U7MB@28211|Alphaproteobacteria,2KAHV@204457|Sphingomonadales 204457|Sphingomonadales L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_16949_1 1229909.NSED_08020 5.69e-105 316.0 COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota 651137|Thaumarchaeota F adenylosuccinate lyase - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_16949_2 436308.Nmar_1466 1.32e-49 164.0 COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_32569_1 335283.Neut_1808 2.32e-11 64.3 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM glycosyl transferase, family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_23642_2 279303.Q6J7X1_9CAUD 5.95e-141 410.0 4QCM9@10239|Viruses,4QVZV@35237|dsDNA viruses no RNA stage,4QTYN@28883|Caudovirales,4QMZ7@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_3779_2 1267533.KB906738_gene2292 1.01e-31 114.0 COG2044@1|root,COG2044@2|Bacteria 2|Bacteria - - - - - ko:K06039 - - - - ko00000 - - - DrsE k59_3779_3 314292.VAS14_12104 1.4e-22 91.7 2B8FG@1|root,321QJ@2|Bacteria,1QM06@1224|Proteobacteria,1TJ6T@1236|Gammaproteobacteria,1Y0QD@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_45865_1 608538.HTH_0299 6.38e-10 64.3 COG0491@1|root,COG0491@2|Bacteria,2G4R1@200783|Aquificae 200783|Aquificae S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_8027_1 257310.BB3148 5.08e-16 82.8 COG4638@1|root,COG4638@2|Bacteria,1N6MJ@1224|Proteobacteria,2VP2U@28216|Betaproteobacteria 28216|Betaproteobacteria P rieske 2fe-2s - - - ko:K00479 - - - - ko00000 - - - Rieske,Ring_hydroxyl_A k59_39247_1 1229909.NSED_02155 4.14e-115 336.0 COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota 651137|Thaumarchaeota C Pyruvate ferredoxin oxidoreductase beta subunit C terminal - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_14887_1 1131266.ARWQ01000004_gene1477 1.34e-26 107.0 COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA Topoisomerase I (eukaryota) - - 5.99.1.2 ko:K03163 - - - - ko00000,ko01000,ko03032 - - - Topo_C_assoc,Topoisom_I,Topoisom_I_N k59_14887_2 436308.Nmar_1323 1.36e-37 140.0 arCOG11445@1|root,arCOG11445@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_3787_1 1229909.NSED_00830 3.78e-113 344.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_10330_1 517417.Cpar_1700 2.69e-107 322.0 COG3004@1|root,COG3004@2|Bacteria,1FDWE@1090|Chlorobi 1090|Chlorobi P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_10439_2 999541.bgla_1g02810 4.57e-81 242.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,1K762@119060|Burkholderiaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_52608_1 469660.A8HNX4_9CAUD 1.91e-36 137.0 4QBFN@10239|Viruses,4QXWN@35237|dsDNA viruses no RNA stage,4QPTW@28883|Caudovirales,4QNPZ@10744|Podoviridae 10744|Podoviridae S Phage stabilisation protein - - - - - - - - - - - - - k59_32736_1 395494.Galf_0761 5.52e-29 111.0 COG0784@1|root,COG0789@1|root,COG0784@2|Bacteria,COG0789@2|Bacteria,1RGD3@1224|Proteobacteria,2VUMK@28216|Betaproteobacteria 28216|Betaproteobacteria T Response regulator receiver - - - - - - - - - - - - HTH_17,Response_reg k59_65888_1 1229909.NSED_00700 2.76e-24 100.0 COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH k59_65888_2 1229909.NSED_00705 2.13e-33 125.0 COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the HMG-CoA reductase family - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_63934_1 436308.Nmar_1511 4.26e-124 363.0 COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_39404_1 251221.35211574 1.3e-35 133.0 COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria 1117|Cyanobacteria J Histone methylation protein DOT1 - - - - - - - - - - - - Methyltransf_25 k59_42146_1 639030.JHVA01000001_gene251 7.79e-73 233.0 COG0364@1|root,COG0364@2|Bacteria,3Y627@57723|Acidobacteria,2JKTN@204432|Acidobacteriia 204432|Acidobacteriia G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_59918_1 436308.Nmar_1078 1.52e-113 333.0 COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota 651137|Thaumarchaeota E DeoC/LacD family aldolase - - 2.3.1.245 ko:K08321 ko02024,map02024 - - - ko00000,ko00001,ko01000 - - - DeoC k59_59918_2 436308.Nmar_1079 6.81e-15 72.8 COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota 651137|Thaumarchaeota C Glucose dehydrogenase C-terminus - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_13153_1 1229909.NSED_05290 5.93e-94 281.0 COG2064@1|root,arCOG01808@2157|Archaea 2157|Archaea NU Type II secretion system - - - ko:K07333 - - - - ko00000,ko02035,ko02044 - - - T2SSF k59_17737_1 1123487.KB892866_gene1797 1.44e-49 169.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_22179_1 436308.Nmar_0051 2.42e-61 195.0 arCOG08818@1|root,arCOG08818@2157|Archaea,41SVV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_30971_1 287.DR97_455 6.59e-07 49.7 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria,1YF2T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E ATPases associated with a variety of cellular activities gltL GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21 ko:K02028,ko:K02029,ko:K10004 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - iAPECO1_1312.APECO1_1411,iE2348C_1286.E2348C_0545,iECOK1_1307.ECOK1_0655,iECP_1309.ECP_0675,iECS88_1305.ECS88_0687,iEcSMS35_1347.EcSMS35_0673,iUMN146_1321.UM146_14290,iUTI89_1310.UTI89_C0648 ABC_tran k59_30971_2 460265.Mnod_4479 3.31e-75 231.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TQZ7@28211|Alphaproteobacteria,1JSBB@119045|Methylobacteriaceae 28211|Alphaproteobacteria P TIGRFAM polar amino acid ABC transporter, inner membrane subunit gltK - - ko:K02029,ko:K10002 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_39940_2 279303.Q6J824_9CAUD 1.81e-38 144.0 4QF1F@10239|Viruses,4QZU3@35237|dsDNA viruses no RNA stage,4QSH1@28883|Caudovirales,4QKX4@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_48684_2 420324.KI912045_gene4316 2.5e-13 68.2 28W7U@1|root,2ZI8E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_42162_1 1229909.NSED_01160 6.59e-15 71.2 COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Nicotinamide-nucleotide adenylyltransferase - - - - - - - - - - - - - k59_42162_2 436308.Nmar_0253 2.7e-104 306.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_26488_1 580332.Slit_1269 2.91e-43 153.0 COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc,PEGA k59_53249_1 641147.HMPREF9021_00055 2.93e-32 121.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2VIZ6@28216|Betaproteobacteria,2KQR7@206351|Neisseriales 206351|Neisseriales G Phosphoglycolate phosphatase gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_30999_1 1454004.AW11_03085 6.2e-82 265.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_8862_1 436308.Nmar_1794 1.85e-117 366.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_55473_1 1229909.NSED_01935 4.57e-28 104.0 COG1841@1|root,arCOG04086@2157|Archaea,41SMX@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_55473_2 436308.Nmar_0401 2.89e-84 250.0 COG0200@1|root,arCOG00779@2157|Archaea,41SQY@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl15 - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_28838_1 1305735.JAFT01000005_gene2482 9.81e-09 58.2 COG1638@1|root,COG1638@2|Bacteria,1MUJY@1224|Proteobacteria,2TQNU@28211|Alphaproteobacteria,2PE0C@252301|Oceanicola 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_28847_1 1229909.NSED_07735 6.56e-110 333.0 COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_13211_1 1276756.AUEX01000014_gene2899 4.16e-26 105.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,4A9QY@80864|Comamonadaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_13211_2 1000565.METUNv1_02663 8.64e-50 165.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,2KU7Q@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_31041_1 1051646.VITU9109_14061 3.3e-16 83.6 COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Pkd domain containing protein - - - - - - - - - - - - - k59_26567_1 436308.Nmar_0333 2.36e-46 171.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_31057_1 436308.Nmar_1718 7.64e-96 286.0 COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota 651137|Thaumarchaeota S kinase, sugar kinase superfamily - - 2.7.1.169 ko:K06982 ko00770,ko01100,map00770,map01100 - R09378 RC00002,RC00017 ko00000,ko00001,ko01000 - - - GHMP_kinases_N k59_31057_2 436308.Nmar_1717 1.57e-61 197.0 COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate uptake regulator - - - - - - - - - - - - PhoU k59_48748_1 1268237.G114_06567 1.64e-43 149.0 28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1THJU@1236|Gammaproteobacteria,1Y64V@135624|Aeromonadales 135624|Aeromonadales - - - - - - - - - - - - - - - k59_26592_1 1112274.KI911560_gene889 1.4e-84 262.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,2KNE8@206350|Nitrosomonadales 206350|Nitrosomonadales L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_13255_1 1454004.AW11_03085 1.11e-35 135.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_13255_2 1125973.JNLC01000004_gene3117 2.35e-25 105.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_13268_1 436308.Nmar_0267 4.4e-68 212.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_13268_2 1229909.NSED_01230 2.03e-12 60.8 COG5466@1|root,arCOG05278@2157|Archaea,41T8X@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1059) - - - - - - - - - - - - DUF1059 k59_48778_1 1502851.FG93_01002 4.04e-53 172.0 29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2U5KG@28211|Alphaproteobacteria,3JYK2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB k59_48855_2 288000.BBta_1644 1.31e-52 180.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,3JUFH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family MA20_06195 - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_26649_2 1097668.BYI23_E002200 6.72e-09 57.4 COG2801@1|root,COG2801@2|Bacteria,1PUMN@1224|Proteobacteria,2VKGM@28216|Betaproteobacteria,1K4P1@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - rve k59_28875_1 7668.SPU_008426-tr 2.17e-38 150.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_2229_1 1131266.ARWQ01000017_gene887 1.17e-68 217.0 COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - - - - - - - - - - - Radical_SAM k59_2229_2 436308.Nmar_0555 5.79e-18 82.4 COG0043@1|root,arCOG01671@2157|Archaea,41S94@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_57756_1 436308.Nmar_1549 3.74e-74 233.0 COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_57756_2 436308.Nmar_1548 1.63e-13 69.7 COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota 651137|Thaumarchaeota H ThiF family - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF,ThiS k59_26667_1 7668.SPU_000868-tr 2.51e-33 136.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39NE5@33154|Opisthokonta,3CPYS@33208|Metazoa,3E63Y@33213|Bilateria 2759|Eukaryota S Endonuclease-reverse transcriptase - - - - - - - - - - - - RVT_1 k59_66637_1 1229909.NSED_01245 1.71e-116 342.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_39997_1 1163617.SCD_n00046 5.38e-35 124.0 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,2VVT5@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_31104_1 436308.Nmar_1515 5.19e-105 309.0 COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota 651137|Thaumarchaeota S ATPase family associated with various cellular activities (AAA) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5 k59_28903_1 436308.Nmar_0392 4.61e-108 324.0 COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota 651137|Thaumarchaeota C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_42216_1 640081.Dsui_1785 1.16e-08 62.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VHVG@28216|Betaproteobacteria,2KX8G@206389|Rhodocyclales 206389|Rhodocyclales M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_8 k59_37803_1 1157708.KB907477_gene1065 1.12e-30 119.0 COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,2VNFR@28216|Betaproteobacteria,4AGGA@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2167) - - - - - - - - - - - - DUF2167 k59_20032_1 436308.Nmar_1757 1.74e-13 65.1 COG1761@1|root,arCOG04111@2157|Archaea,41SV9@651137|Thaumarchaeota 651137|Thaumarchaeota K RNA polymerase Rpb3/Rpb11 dimerisation domain - - 2.7.7.6 ko:K03056 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_L_2 k59_20032_2 1229909.NSED_09360 1.56e-61 193.0 arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_40020_1 1229909.NSED_01965 3.32e-91 275.0 COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota 651137|Thaumarchaeota J Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs truB - - ko:K11131 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03032 - - - DKCLD,PUA,TruB_C_2,TruB_N k59_8926_1 436308.Nmar_1699 2.3e-104 306.0 arCOG08770@1|root,arCOG08770@2157|Archaea,41T2S@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_8926_2 1229909.NSED_09050 4.33e-15 73.6 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_11140_1 565033.GACE_1061 3.42e-07 56.6 COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2461Y@183980|Archaeoglobi 183980|Archaeoglobi P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_15581_1 1229909.NSED_08190 1.04e-113 342.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_11154_1 1366046.HIMB11_02127 4.05e-17 79.7 2DKXA@1|root,30R3Q@2|Bacteria,1RGIH@1224|Proteobacteria,2U71W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB k59_37821_1 945713.IALB_2980 4.37e-24 96.7 2E5WH@1|root,330KI@2|Bacteria 2|Bacteria J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_37821_2 395492.Rleg2_1002 0.000177 43.1 COG3293@1|root,COG3293@2|Bacteria,1REX3@1224|Proteobacteria,2U89Y@28211|Alphaproteobacteria,4BM8S@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_44504_1 1123368.AUIS01000013_gene852 2.61e-97 301.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,2NCB0@225057|Acidithiobacillales 1236|Gammaproteobacteria G Protein of unknown function (DUF3417) - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_62243_1 153948.NAL212_2704 9.21e-85 258.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,37209@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_55562_1 1229755.K7R2J6_9CAUD 1.83e-35 134.0 4QASV@10239|Viruses,4QWD9@35237|dsDNA viruses no RNA stage,4QQ4N@28883|Caudovirales 28883|Caudovirales S recA bacterial DNA recombination protein - - - - - - - - - - - - - k59_46273_1 1008459.TASI_1128 0.000122 49.7 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,3T32Z@506|Alcaligenaceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_50554_1 1255043.TVNIR_2177 3.06e-51 175.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales 135613|Chromatiales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_50554_2 522306.CAP2UW1_2537 4.5e-10 57.0 COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2VWG5@28216|Betaproteobacteria,1KR5I@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Cytochrome oxidase maturation protein cbb3-type ccoS - - - - - - - - - - - FixS k59_46283_1 436308.Nmar_1223 4.16e-26 106.0 COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48) domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_46283_2 1459636.NTE_01660 4.06e-22 89.0 arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_46283_3 436308.Nmar_1225 4.94e-51 168.0 COG0109@1|root,arCOG00479@2157|Archaea,41SDQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_66090_1 436308.Nmar_0863 8.2e-80 248.0 COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota 651137|Thaumarchaeota S LOR SDH bifunctional - - - - - - - - - - - - Saccharop_dh_N k59_70787_2 757424.Hsero_0230 2.66e-11 64.7 2E645@1|root,330T3@2|Bacteria,1NEGX@1224|Proteobacteria,2VY99@28216|Betaproteobacteria 28216|Betaproteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_24039_1 15368.BRADI2G40377.1 1.21e-73 262.0 COG2801@1|root,KOG0017@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,3M4DI@4447|Liliopsida,3INP4@38820|Poales 35493|Streptophyta L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVP_2,RVT_1,Retrotrans_gag,rve,zf-CCHC k59_21829_1 436308.Nmar_1538 2.78e-39 130.0 arCOG08782@1|root,arCOG08782@2157|Archaea,41SVH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_44068_1 1229909.NSED_01600 3.61e-63 217.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_4136_2 748247.AZKH_0072 2.01e-32 128.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,2KVUW@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_10 k59_19547_1 595460.RRSWK_05984 4.23e-48 168.0 COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_4139_1 1229909.NSED_00830 1.84e-127 382.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_4139_2 436308.Nmar_0205 6.34e-41 137.0 COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota 651137|Thaumarchaeota L RNase H - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 k59_50564_1 436308.Nmar_0299 1.64e-138 405.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_50566_1 323848.Nmul_A0705 4.54e-92 279.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,372TZ@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_46296_1 1123368.AUIS01000018_gene729 2.54e-67 220.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,2NC1Z@225057|Acidithiobacillales 225057|Acidithiobacillales P major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_15280_1 377629.TERTU_2539 3.96e-56 186.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria,2PPCA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Stage II sporulation protein M - - - - - - - - - - - - SpoIIM k59_37426_1 10224.XP_006825930.1 4.06e-40 154.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria 33208|Metazoa G positive regulation of TOR signaling - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_26177_1 1121937.AUHJ01000045_gene1233 5.24e-36 133.0 COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria,468CJ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,HTH_29,rve k59_8469_1 436229.JOEH01000021_gene7646 1.97e-49 169.0 COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria,2NI8Z@228398|Streptacidiphilus 201174|Actinobacteria G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_48303_1 1131266.ARWQ01000010_gene28 2.66e-50 167.0 COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_48303_2 1229909.NSED_01525 9.93e-60 189.0 COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS2 family rps2 - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_35474_1 7668.SPU_016539-tr 3.96e-33 131.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3BPSU@33208|Metazoa,3E41R@33213|Bilateria 33208|Metazoa IQ Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_28465_1 1229909.NSED_01965 3.44e-132 381.0 COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota 651137|Thaumarchaeota J Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs truB - - ko:K11131 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03032 - - - DKCLD,PUA,TruB_C_2,TruB_N k59_61867_1 1229909.NSED_04945 6.76e-94 279.0 COG1651@1|root,arCOG02868@2157|Archaea,41T2W@651137|Thaumarchaeota 651137|Thaumarchaeota O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 k59_41809_1 404589.Anae109_3203 1.57e-21 89.4 COG0664@1|root,COG0664@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria,2YVYQ@29|Myxococcales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HEAT_2,cNMP_binding k59_41809_2 1123504.JQKD01000031_gene4578 3.3e-20 88.6 2EGFZ@1|root,33A7Y@2|Bacteria,1NI1P@1224|Proteobacteria,2VY2Y@28216|Betaproteobacteria,4AFVJ@80864|Comamonadaceae 28216|Betaproteobacteria S Ribosomal protein L7/L12 C-terminal domain - - - - - - - - - - - - Ribosomal_L12 k59_30686_1 1500894.JQNN01000001_gene3322 3.84e-74 241.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,473CU@75682|Oxalobacteraceae 28216|Betaproteobacteria V ABC transporter transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_26189_1 313606.M23134_04297 2.82e-55 194.0 28J0S@1|root,2Z8XX@2|Bacteria,4P2J4@976|Bacteroidetes,47X8E@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_59620_1 85643.Tmz1t_0821 1.94e-43 144.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,2KWF2@206389|Rhodocyclales 206389|Rhodocyclales J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_59620_2 596154.Alide2_1836 3.54e-12 66.2 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VK7F@28216|Betaproteobacteria,4AJ1Q@80864|Comamonadaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_64212_1 436308.Nmar_1302 2.29e-103 308.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 k59_4199_1 426117.M446_1580 3.07e-40 147.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TYKE@28211|Alphaproteobacteria,1JZI1@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_17405_1 420324.KI912061_gene6194 4.76e-42 157.0 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria,1JXBR@119045|Methylobacteriaceae 28211|Alphaproteobacteria T GAF domain - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_52898_1 748280.NH8B_2022 4.97e-50 174.0 COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria 28216|Betaproteobacteria M Protein of unknown function (DUF3300) - - - - - - - - - - - - DUF3300 k59_30695_1 436308.Nmar_1691 3.06e-116 348.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_48331_1 1278073.MYSTI_01540 2.95e-42 150.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,43BDP@68525|delta/epsilon subdivisions,2WTRS@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_19591_1 436308.Nmar_0243 2.56e-62 210.0 COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks hel308 - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,HHH_5,Helicase_C k59_19591_2 436308.Nmar_0244 8.72e-14 71.2 COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family - - 2.7.8.15 ko:K01001 ko00510,ko01100,map00510,map01100 M00055 R05969 RC00002 ko00000,ko00001,ko00002,ko01000,ko01003 - - - Glycos_transf_4 k59_66165_1 1229909.NSED_00180 3.85e-117 353.0 COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota 651137|Thaumarchaeota O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_55118_1 279303.Q6J7Z7_9CAUD 4.18e-10 64.3 4QCIV@10239|Viruses,4QUB8@28883|Caudovirales,4QM5R@10699|Siphoviridae 10699|Siphoviridae S Methyltransferase domain - - - - - - - - - - - - - k59_55118_2 563192.HMPREF0179_03258 4.52e-21 92.8 COG3617@1|root,COG3645@1|root,COG3617@2|Bacteria,COG3645@2|Bacteria,1NVWI@1224|Proteobacteria,4306R@68525|delta/epsilon subdivisions,2WVFK@28221|Deltaproteobacteria,2MEY6@213115|Desulfovibrionales 28221|Deltaproteobacteria K Phage antirepressor protein KilAC domain - - - - - - - - - - - - ANT,Bro-N k59_1974_1 667632.KB890195_gene3470 1.17e-19 85.9 COG0596@1|root,COG0596@2|Bacteria,1N3G3@1224|Proteobacteria,2WH3B@28216|Betaproteobacteria,1KIHJ@119060|Burkholderiaceae 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_62010_1 266264.Rmet_2141 1.06e-42 152.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,1K29F@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_13002_2 1229909.NSED_03105 1.11e-71 225.0 COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota 651137|Thaumarchaeota O Trypsin-like serine protease with C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_70954_1 1346330.M472_21305 2.11e-26 116.0 COG0726@1|root,COG2931@1|root,COG3291@1|root,COG4733@1|root,COG4886@1|root,COG4932@1|root,COG0726@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria,COG4932@2|Bacteria,4NKGW@976|Bacteroidetes,1IWKC@117747|Sphingobacteriia 976|Bacteroidetes GMQ domain, Protein - - - - - - - - - - - - - k59_37629_1 1229909.NSED_06570 1.98e-07 51.6 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_37629_2 436308.Nmar_0021 1.3e-79 251.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_24282_1 460265.Mnod_4822 6.08e-34 125.0 COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae 28211|Alphaproteobacteria H PFAM formyl transferase domain protein - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_24282_2 744985.HIMB59_00013810 3.05e-30 119.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BPJW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C acyl-CoA transferases carnitine dehydratase frc - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_62015_1 13735.ENSPSIP00000000799 2.6e-89 282.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_26332_1 948106.AWZT01000013_gene909 7.28e-106 318.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1K273@119060|Burkholderiaceae 28216|Betaproteobacteria C glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_64379_1 272560.BPSL2761 1.77e-70 221.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1K1BT@119060|Burkholderiaceae 28216|Betaproteobacteria U PFAM MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_30804_1 436308.Nmar_0339 4.42e-99 299.0 COG1641@1|root,arCOG02701@2157|Archaea,41SDC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function DUF111 - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_48486_1 7955.ENSDARP00000109600 1.63e-26 109.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A5PS@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_28623_1 6500.XP_005096724.1 6.41e-94 284.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3A2E1@33154|Opisthokonta,3BRAZ@33208|Metazoa,3D7Y6@33213|Bilateria 33208|Metazoa S Endonuclease-reverse transcriptase - - - - - - - - - - - - Exo_endo_phos_2 k59_8636_2 1163617.SCD_n00091 3.96e-96 286.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria 28216|Betaproteobacteria L exodeoxyribonuclease iii exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_10888_1 1207063.P24_03840 9.76e-128 371.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria,2JQRM@204441|Rhodospirillales 204441|Rhodospirillales G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component dctP - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_8643_1 710685.MycrhN_2183 2.14e-06 55.8 COG4655@1|root,COG4655@2|Bacteria,2I756@201174|Actinobacteria,23FGR@1762|Mycobacteriaceae 201174|Actinobacteria S Putative Flp pilus-assembly TadE/G-like - - - - - - - - - - - - - k59_66309_1 7668.SPU_008426-tr 2.46e-22 102.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_4356_1 1229909.NSED_09030 2.8e-45 152.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_55259_1 1123354.AUDR01000013_gene516 4.46e-179 513.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KS6X@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_26363_1 279303.Q6J7Z7_9CAUD 1.63e-91 287.0 4QCIV@10239|Viruses,4QUB8@28883|Caudovirales,4QM5R@10699|Siphoviridae 10699|Siphoviridae S Methyltransferase domain - - - - - - - - - - - - - k59_26363_2 279303.Q6J7Z8_9CAUD 1.59e-36 130.0 4QCXA@10239|Viruses,4QUZI@35237|dsDNA viruses no RNA stage,4QPBH@28883|Caudovirales,4QMAJ@10699|Siphoviridae 10699|Siphoviridae S transferase activity - - - - - - - - - - - - - k59_30843_1 582744.Msip34_0498 5.02e-57 200.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KKHN@206350|Nitrosomonadales 206350|Nitrosomonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_22043_1 748247.AZKH_1721 1.77e-34 133.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,2KUB6@206389|Rhodocyclales 206389|Rhodocyclales ET His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_22043_2 395495.Lcho_0237 1.82e-17 76.6 COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,2VT7U@28216|Betaproteobacteria,1KNW7@119065|unclassified Burkholderiales 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_8654_1 10224.XP_006813780.1 1.09e-50 175.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y9N@33154|Opisthokonta,3BKRZ@33208|Metazoa,3CWQ0@33213|Bilateria 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_33121_1 933262.AXAM01000051_gene2992 4.7e-64 204.0 COG3385@1|root,COG3385@2|Bacteria,1RK05@1224|Proteobacteria 1224|Proteobacteria L transposase activity - - - - - - - - - - - - - k59_55278_1 1288494.EBAPG3_2050 1.41e-40 134.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,373I5@32003|Nitrosomonadales 28216|Betaproteobacteria K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_66322_1 1229909.NSED_01685 2.18e-56 187.0 arCOG08777@1|root,arCOG08800@1|root,arCOG08777@2157|Archaea,arCOG08800@2157|Archaea 2157|Archaea L metallopeptidase activity - - - - - - - - - - - - CHB_HEX_C_1,Polysacc_deac_1 k59_50757_1 244582.JQAK01000001_gene1891 1.18e-47 155.0 COG3293@1|root,COG3293@2|Bacteria,1Q8IA@1224|Proteobacteria,2UWD1@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DUF4096 k59_50757_2 244582.JQAK01000001_gene1892 2.1e-70 216.0 COG3293@1|root,COG3293@2|Bacteria,1Q8IA@1224|Proteobacteria,2UWD1@28211|Alphaproteobacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_59802_1 1458427.BAWN01000035_gene1977 1.77e-56 181.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,4AAJV@80864|Comamonadaceae 28216|Betaproteobacteria K transcriptional regulator, Rrf2 family iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_26391_1 637389.Acaty_c2281 3.28e-74 240.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales 225057|Acidithiobacillales P STAS domain - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_4371_1 1007105.PT7_3034 3.63e-11 63.5 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T1XI@506|Alcaligenaceae 28216|Betaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_4371_2 1120956.JHZK01000002_gene1019 2.57e-52 169.0 COG1917@1|root,COG1917@2|Bacteria,1MYMN@1224|Proteobacteria,2UR93@28211|Alphaproteobacteria 28211|Alphaproteobacteria S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_55997_1 436308.Nmar_0471 1.8e-89 283.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_58261_1 1187851.A33M_3521 1.28e-89 272.0 COG1529@1|root,COG1529@2|Bacteria,1NPGE@1224|Proteobacteria,2TTCC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C aerobic-type carbon monoxide dehydrogenase, large subunit CoxL MA20_13970 - - - - - - - - - - - Ald_Xan_dh_C2 k59_42715_1 580332.Slit_2201 1.76e-06 49.3 COG0349@1|root,COG0349@2|Bacteria,1REMB@1224|Proteobacteria,2VQQC@28216|Betaproteobacteria,44WFH@713636|Nitrosomonadales 28216|Betaproteobacteria L 3'-5' exonuclease - - - - - - - - - - - - DNA_pol_A_exo1 k59_42715_2 194867.ALBQ01000014_gene423 2.89e-32 120.0 COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2U5HN@28211|Alphaproteobacteria,2K2C2@204457|Sphingomonadales 204457|Sphingomonadales S Methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_38293_1 436308.Nmar_1790 1.06e-90 278.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_38293_2 436308.Nmar_1789 1.04e-29 110.0 COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota 651137|Thaumarchaeota L protein conserved in archaea - - - ko:K09723 - - - - ko00000,ko03032 - - - - k59_27172_1 1229909.NSED_09780 2.99e-82 248.0 COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_548_1 1131266.ARWQ01000001_gene1150 6.86e-71 218.0 COG2860@1|root,arCOG04641@2157|Archaea,41SIS@651137|Thaumarchaeota 651137|Thaumarchaeota S UPF0126 domain - - - - - - - - - - - - UPF0126 k59_69362_1 1049564.TevJSym_ad00810 8.6e-17 80.9 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1J530@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FP Belongs to the GppA Ppx family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_67176_1 1266925.JHVX01000002_gene869 9.55e-139 417.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,371VX@32003|Nitrosomonadales 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_51539_2 1459636.NTE_03540 5.93e-30 114.0 COG3794@1|root,arCOG02929@2157|Archaea,41T61@651137|Thaumarchaeota 651137|Thaumarchaeota C Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 k59_58277_1 1175306.GWL_35780 7.87e-137 402.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,4726R@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_16005_1 1280944.HY17_04665 1.54e-22 94.7 2FI5T@1|root,349YH@2|Bacteria,1P1M3@1224|Proteobacteria,2UVNQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_2780_3 244581.IM40_03330 6.35e-21 89.7 COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,47FJ2@766|Rickettsiales 766|Rickettsiales S protein conserved in bacteria - - - ko:K09985 - - - - ko00000 - - - SspB k59_49414_1 1380391.JIAS01000012_gene4422 3.6e-52 180.0 COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales 204441|Rhodospirillales Q Homospermidine synthase hss - 2.5.1.44 ko:K00808 ko00960,ko01110,map00960,map01110 - R00018 RC00053 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_62733_2 1229909.NSED_09845 2.67e-85 259.0 COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_36054_1 1232437.KL662047_gene5143 1.84e-82 254.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,42MVH@68525|delta/epsilon subdivisions,2WMHB@28221|Deltaproteobacteria,2MME3@213118|Desulfobacterales 28221|Deltaproteobacteria HJ Sugar-transfer associated ATP-grasp - - - - - - - - - - - - ATPgrasp_ST k59_47138_1 436308.Nmar_1684 1.16e-107 323.0 arCOG08795@1|root,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_62743_1 666681.M301_0594 8.96e-68 220.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KKDR@206350|Nitrosomonadales 206350|Nitrosomonadales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_606_1 536019.Mesop_2857 1.87e-72 227.0 COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2U3WG@28211|Alphaproteobacteria,43KHM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.15 ko:K13874,ko:K14274 ko00040,ko00053,ko01100,map00040,map00053,map01100 - R02427,R02526 RC00537,RC00713 ko00000,ko00001,ko01000 - - - SGL k59_40482_1 215358.XP_010743720.1 6.18e-60 209.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_13882_1 314278.NB231_16693 4.61e-76 248.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1WWN6@135613|Chromatiales 135613|Chromatiales E Extracellular solute-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_4910_1 1229909.NSED_04180 1.03e-94 283.0 COG3794@1|root,arCOG02926@2157|Archaea,41T8E@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Copper binding proteins, plastocyanin azurin family - - - - - - - - - - - - Copper-bind k59_22723_1 1380347.JNII01000009_gene2003 4.07e-54 176.0 COG2128@1|root,COG2128@2|Bacteria,2HTUG@201174|Actinobacteria,4EUKU@85013|Frankiales 201174|Actinobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - - k59_16062_1 595537.Varpa_4651 1.38e-117 346.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,4A9XB@80864|Comamonadaceae 28216|Betaproteobacteria E amino acid urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_51582_1 1229909.NSED_09085 1.25e-71 220.0 COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota 651137|Thaumarchaeota F thymidylate kinase tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_45012_1 7668.SPU_021590-tr 8.53e-43 160.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3AMSR@33154|Opisthokonta,3C0N6@33208|Metazoa,3DH1R@33213|Bilateria 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2 k59_45015_1 1163617.SCD_n00794 4.67e-62 209.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_45015_2 76114.ebD83 4.86e-19 79.7 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,2KWPQ@206389|Rhodocyclales 206389|Rhodocyclales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_11605_1 1128421.JAGA01000001_gene2258 1.22e-39 146.0 COG0559@1|root,COG0559@2|Bacteria 2|Bacteria E leucine import across plasma membrane MA20_23490 - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1284_1 1266925.JHVX01000007_gene2354 2.17e-67 223.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,371T2@32003|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_32361_2 1218084.BBJK01000142_gene7359 0.000223 43.9 COG0662@1|root,COG0662@2|Bacteria,1QU63@1224|Proteobacteria,2VNQW@28216|Betaproteobacteria,1K6YY@119060|Burkholderiaceae 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_5540_1 264462.Bd3385 8.37e-12 70.9 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2MSNF@213481|Bdellovibrionales,2WKHJ@28221|Deltaproteobacteria 213481|Bdellovibrionales E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_10055_1 82654.Pse7367_0444 6.45e-29 109.0 COG2259@1|root,COG2259@2|Bacteria,1G88A@1117|Cyanobacteria,1HCCW@1150|Oscillatoriales 1117|Cyanobacteria S PFAM DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX,SURF4 k59_34703_1 279303.Q6J812_9CAUD 7.88e-82 250.0 4QC5U@10239|Viruses,4QZE3@35237|dsDNA viruses no RNA stage,4QRPX@28883|Caudovirales,4QMVC@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_1291_1 977880.RALTA_B0210 2.66e-29 115.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_32381_1 7994.ENSAMXP00000026812 4.18e-34 134.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_63515_1 436308.Nmar_1596 5.71e-96 281.0 COG1607@1|root,arCOG00773@2157|Archaea,41T2J@651137|Thaumarchaeota 651137|Thaumarchaeota I Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_63515_2 436308.Nmar_1595 1.21e-22 90.1 arCOG10592@1|root,arCOG10594@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_56729_1 448385.sce6983 1.15e-93 288.0 COG3209@1|root,COG3385@1|root,COG3209@2|Bacteria,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,437YG@68525|delta/epsilon subdivisions,2X38D@28221|Deltaproteobacteria,2YUTS@29|Myxococcales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_58993_1 1229909.NSED_09410 1.26e-142 414.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_34728_1 1123070.KB899254_gene1143 1.25e-06 55.5 29ZF4@1|root,30MEG@2|Bacteria,46XJJ@74201|Verrucomicrobia,2IW2V@203494|Verrucomicrobiae 203494|Verrucomicrobiae - - - - - - - - - - - - - - - k59_10091_2 1268237.G114_04591 8.66e-05 45.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Y3ZA@135624|Aeromonadales 135624|Aeromonadales T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg k59_56738_1 580332.Slit_2622 1.61e-56 191.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,44VD5@713636|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_47669_1 522306.CAP2UW1_2161 7.74e-96 292.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKJI@28216|Betaproteobacteria,1KPPN@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_25585_1 1266925.JHVX01000007_gene2376 7.5e-96 299.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,372MQ@32003|Nitrosomonadales 28216|Betaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_27838_1 640081.Dsui_3444 1.29e-98 296.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales 206389|Rhodocyclales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_52273_1 400682.PAC_15708125 9.31e-50 182.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa 33208|Metazoa OU K02A2.6-like - - - - - - - - - - - - RVT_1,rve,zf-H2C2 k59_21203_1 522306.CAP2UW1_3466 1.23e-25 107.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,1KQEA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V ABC transporter transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_19048_1 537011.PREVCOP_06008 5.74e-10 63.9 COG1234@1|root,COG1234@2|Bacteria,4NE1K@976|Bacteroidetes,2FM13@200643|Bacteroidia 976|Bacteroidetes S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_19048_2 1131266.ARWQ01000014_gene82 5.17e-25 99.4 COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota 651137|Thaumarchaeota K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_36788_1 1071679.BG57_00640 6.51e-87 265.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,1JZPY@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome d ubiquinol oxidase, subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_21221_1 436308.Nmar_1295 9.25e-152 429.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_25622_1 1123354.AUDR01000017_gene51 2.01e-24 100.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1KRG6@119069|Hydrogenophilales 119069|Hydrogenophilales E ArgJ family - - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ ## 1020 queries scanned ## Total time (seconds): 56.82245898246765 ## Rate: 17.95 q/s