## Sat Jan 4 01:46:38 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA629394/SRR11734628/SRR11734628_p_cluster_rep_seq.fasta --output PRJNA629394_SRR11734628 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_27658_1 76114.ebA562 5.51e-47 166.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,2KYF1@206389|Rhodocyclales 206389|Rhodocyclales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_50310_1 330214.NIDE1317 2.63e-111 323.0 COG0092@1|root,COG0092@2|Bacteria,3J0AP@40117|Nitrospirae 40117|Nitrospirae J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_17030_1 485915.Dret_1154 9.87e-30 120.0 COG0714@1|root,COG0714@2|Bacteria,1QUGB@1224|Proteobacteria,43BNV@68525|delta/epsilon subdivisions,2X705@28221|Deltaproteobacteria 28221|Deltaproteobacteria S ATPases associated with a variety of cellular activities - - - - - - - - - - - - - k59_18799_2 13349.G1XST4 0.000121 48.5 COG1472@1|root,2QTNX@2759|Eukaryota,39UHS@33154|Opisthokonta,3NWI4@4751|Fungi,3QJRH@4890|Ascomycota 4751|Fungi G Glycoside hydrolase family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,Glyco_hydro_3 k59_1547_1 1298593.TOL_3238 1.27e-60 209.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XHZK@135619|Oceanospirillales 135619|Oceanospirillales U Type II and III secretion system protein pilQ - - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_33073_1 330214.NIDE1574 1.12e-65 210.0 COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_14,Mob_synth_C,Radical_SAM k59_36435_1 391612.CY0110_12607 3.24e-28 115.0 COG0628@1|root,COG0628@2|Bacteria,1G26W@1117|Cyanobacteria,3KG14@43988|Cyanothece 1117|Cyanobacteria S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_55341_1 203122.Sde_0056 0.000163 49.3 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,1RSAX@1236|Gammaproteobacteria,4687Z@72275|Alteromonadaceae 1236|Gammaproteobacteria U haemagglutination activity domain rscA - - - - - - - - - - - DUF3739,ESPR,Haemagg_act k59_1553_1 1000565.METUNv1_03890 1.69e-58 194.0 COG2304@1|root,COG2304@2|Bacteria,1MX8R@1224|Proteobacteria,2VT5A@28216|Betaproteobacteria 28216|Betaproteobacteria S von Willebrand factor (vWF) type A domain - - - ko:K16259 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - VWA_2 k59_51997_1 1298593.TOL_3620 1e-31 121.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XHVZ@135619|Oceanospirillales 135619|Oceanospirillales E highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_51997_2 743720.Psefu_3898 1.48e-13 72.8 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S penicillin-binding protein - - - - - - - - - - - - BiPBP_C,DUF4124 k59_36453_1 620914.JH621266_gene1985 5.49e-38 145.0 COG0338@1|root,COG0338@2|Bacteria,4NNKG@976|Bacteroidetes,1I2BU@117743|Flavobacteriia 976|Bacteroidetes L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_8196_1 1089553.Tph_c24250 5.18e-134 397.0 COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales 186801|Clostridia L Transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_8196_2 1197477.IA57_01105 1.25e-05 49.3 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IJXT@117743|Flavobacteriia 976|Bacteroidetes M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_39529_1 1051985.l11_03270 4.97e-13 65.5 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2VSD7@28216|Betaproteobacteria,2KRA0@206351|Neisseriales 206351|Neisseriales E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_44716_1 1121935.AQXX01000085_gene5320 3.46e-38 140.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XHWC@135619|Oceanospirillales 135619|Oceanospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_6796_1 234621.RER_58150 1.22e-10 65.9 COG4188@1|root,COG4188@2|Bacteria,2GMYW@201174|Actinobacteria,4FXBR@85025|Nocardiaceae 201174|Actinobacteria M Chlorophyllase enzyme - - - - - - - - - - - - Chlorophyllase2 k59_20340_1 553385.JEMF01000074_gene1365 1.08e-83 257.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1XIF6@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_25759_1 261292.Nit79A3_3425 1.24e-96 298.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2VMZ8@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_24370_1 522306.CAP2UW1_4362 4.46e-11 62.4 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,1KQ1N@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_24370_2 1123228.AUIH01000014_gene318 2.06e-39 139.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XHC3@135619|Oceanospirillales 135619|Oceanospirillales D Chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_20350_1 330214.NIDE0796 4.29e-57 186.0 COG0331@1|root,COG0331@2|Bacteria,3J0IX@40117|Nitrospirae 40117|Nitrospirae I Acyl transferase domain fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_11940_1 312309.VF_0937 5.67e-35 135.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XTGI@135623|Vibrionales 135623|Vibrionales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains luxO GO:0000156,GO:0000160,GO:0003674,GO:0003700,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K10912 ko02020,ko02024,ko05111,map02020,map02024,map05111 M00513 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1596_1 870967.VIS19158_11094 2.38e-73 228.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1Y2S7@135623|Vibrionales 135623|Vibrionales L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1596_2 283942.IL1626 4.44e-14 67.0 COG2963@1|root,COG2963@2|Bacteria,1PEZA@1224|Proteobacteria,1TAQV@1236|Gammaproteobacteria,2QH1T@267893|Idiomarinaceae 1236|Gammaproteobacteria K Helix-turn-helix domain - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_6829_1 911239.CF149_21938 4.73e-29 113.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria 1236|Gammaproteobacteria N flagellar biosynthetic protein FliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_6829_2 1298593.TOL_2493 8.17e-12 65.5 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1XH8G@135619|Oceanospirillales 135619|Oceanospirillales N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_55389_2 1338011.BD94_1465 7.6e-179 508.0 COG2801@1|root,COG2801@2|Bacteria,4NHJD@976|Bacteroidetes,1IABF@117743|Flavobacteriia 976|Bacteroidetes L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_29,rve,rve_3 k59_22453_1 1298593.TOL_3721 4.34e-103 315.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1XHS4@135619|Oceanospirillales 135619|Oceanospirillales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_29036_1 448385.sce0119 1.08e-44 166.0 COG1361@1|root,COG4719@1|root,COG1361@2|Bacteria,COG4719@2|Bacteria,1R0BA@1224|Proteobacteria,42VBW@68525|delta/epsilon subdivisions,2X811@28221|Deltaproteobacteria,2Z3J2@29|Myxococcales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_17116_1 6412.HelroP179145 5.2e-19 92.4 2D43P@1|root,2STRT@2759|Eukaryota,3AAAX@33154|Opisthokonta,3C18F@33208|Metazoa 33154|Opisthokonta - - - - - - - - - - - - - - RVT_1 k59_25818_1 1150599.MPHLEI_00205 0.00091 42.7 COG2963@1|root,COG2963@2|Bacteria,2GRDS@201174|Actinobacteria,23EYP@1762|Mycobacteriaceae 201174|Actinobacteria L PFAM Transposase IS3 IS911family - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_25818_2 1040989.AWZU01000112_gene4443 1.01e-63 209.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JX5H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_50398_11 460265.Mnod_1984 7.94e-33 141.0 COG5545@1|root,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria L virulence-associated E family protein - - - - - - - - - - - - Prim-Pol,Toprim_3,VirE k59_53840_1 1209072.ALBT01000047_gene461 1.2e-48 173.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1FGF6@10|Cellvibrio 1236|Gammaproteobacteria V ABC transporter transmembrane region hlyB - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_53840_2 1266909.AUAG01000001_gene1592 3.36e-10 62.4 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Type I secretion membrane fusion protein, HlyD hlyD - - ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_55443_1 330214.NIDE0260 4.89e-85 262.0 COG1219@1|root,COG1219@2|Bacteria,3J0AM@40117|Nitrospirae 40117|Nitrospirae O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_50404_1 713586.KB900536_gene2399 2.35e-130 378.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - BNR_6 k59_18926_1 1056820.KB900644_gene766 5.48e-14 69.3 COG2214@1|root,COG2214@2|Bacteria,1RJR1@1224|Proteobacteria,1S0MY@1236|Gammaproteobacteria,2PQHT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_25836_2 1141106.CAIB01000160_gene1519 2.41e-09 57.4 COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,4HNKN@91061|Bacilli,4GZPP@90964|Staphylococcaceae 91061|Bacilli M Diacylglycerol kinase dgkA - 2.7.1.107,2.7.1.66 ko:K00887,ko:K00901 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240,R05626 RC00002,RC00017 ko00000,ko00001,ko01000 - - iSB619.SA_RS07900 DAGK_prokar k59_17136_2 330214.NIDE0008 1.24e-83 249.0 COG2259@1|root,COG2259@2|Bacteria,3J13I@40117|Nitrospirae 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - ko:K15977 - - - - ko00000 - - - DoxX k59_50410_2 716544.wcw_1897 6.01e-90 273.0 COG2801@1|root,COG2801@2|Bacteria,2JHEV@204428|Chlamydiae 204428|Chlamydiae L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve k59_44774_4 1282876.BAOK01000001_gene2595 4.36e-22 98.2 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,4BSA2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Caudovirus prohead serine protease gp35 - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_44774_5 279238.Saro_3122 1.14e-31 131.0 COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2TSSY@28211|Alphaproteobacteria,2K0P2@204457|Sphingomonadales 204457|Sphingomonadales S phage phi-C31 gp36 major capsid-like protein - - - - - - - - - - - - Phage_capsid k59_17991_3 404380.Gbem_2513 0.000127 45.1 COG4980@1|root,COG4980@2|Bacteria,1NEPD@1224|Proteobacteria,42WE2@68525|delta/epsilon subdivisions,2WRDT@28221|Deltaproteobacteria,43SRZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S YtxH-like protein - - - - - - - - - - - - YtxH k59_2240_1 1124849.G9IAC1_9CAUD 6.02e-13 71.2 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales 28883|Caudovirales S phosphoprotein phosphatase activity - - - - - - - - - - - - - k59_43832_1 6500.XP_005099069.1 6.31e-44 167.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39X0S@33154|Opisthokonta,3BF48@33208|Metazoa 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_38618_1 330214.NIDE2750 1.7e-45 148.0 COG2924@1|root,COG2924@2|Bacteria,3J1CU@40117|Nitrospirae 40117|Nitrospirae C Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_35219_1 7668.SPU_003061-tr 4.57e-47 173.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria 33208|Metazoa E K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2 k59_40383_1 1254432.SCE1572_46360 1.69e-85 274.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,43CJE@68525|delta/epsilon subdivisions,2X7TT@28221|Deltaproteobacteria,2Z3N4@29|Myxococcales 28221|Deltaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_2249_2 1254432.SCE1572_11830 2.45e-102 312.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,42Q11@68525|delta/epsilon subdivisions,2WKFK@28221|Deltaproteobacteria 1224|Proteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_23056_1 526227.Mesil_2766 7.07e-85 265.0 COG0475@1|root,COG0475@2|Bacteria,1WIDF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_50935_1 517433.PanABDRAFT_3530 1.29e-05 55.1 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,1RR0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_10812_1 1167006.UWK_02766 1.11e-60 200.0 COG0319@1|root,COG0854@1|root,COG0319@2|Bacteria,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,2MJ54@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1885 PdxJ k59_49251_1 436308.Nmar_1771 4.03e-100 303.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_49252_2 1345695.CLSA_c42340 1.07e-08 60.8 COG0438@1|root,COG0438@2|Bacteria,1VC02@1239|Firmicutes,24NFM@186801|Clostridia,36KUQ@31979|Clostridiaceae 186801|Clostridia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 k59_12592_1 867903.ThesuDRAFT_01262 2.42e-43 155.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,3WCS7@538999|Clostridiales incertae sedis 186801|Clostridia L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_31801_2 317025.Tcr_0348 4.25e-37 135.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,4609M@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_3822_1 1131266.ARWQ01000001_gene1155 6.61e-114 334.0 COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - Trp_halogenase k59_7276_1 244447.XP_008333619.1 2.2e-118 384.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_21267_1 926551.KB900730_gene1716 1.3e-21 87.4 2E4EA@1|root,32Z9I@2|Bacteria,4NTWC@976|Bacteroidetes,1IICT@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_33674_1 926550.CLDAP_23740 3.26e-44 155.0 COG1218@1|root,COG1218@2|Bacteria 2|Bacteria P 3'(2'),5'-bisphosphate nucleotidase activity cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_29985_1 1168065.DOK_12747 1.09e-52 168.0 COG3436@1|root,COG3436@2|Bacteria,1RHJ1@1224|Proteobacteria,1S5UN@1236|Gammaproteobacteria,1J69N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_50961_1 155864.EDL933_1756 6.05e-05 52.0 COG3617@1|root,COG3617@2|Bacteria,1N09A@1224|Proteobacteria,1TAU2@1236|Gammaproteobacteria,3XR7Q@561|Escherichia 1236|Gammaproteobacteria K BRO family, N-terminal domain - - - - - - - - - - - - Bro-N k59_40426_1 293826.Amet_1728 1.99e-09 63.9 COG2227@1|root,COG2227@2|Bacteria,1V1FG@1239|Firmicutes,24MU2@186801|Clostridia 186801|Clostridia H PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_31 k59_35273_1 126957.SMAR007185-PA 2.16e-42 152.0 2CQJ9@1|root,2R501@2759|Eukaryota,39VPP@33154|Opisthokonta,3BH26@33208|Metazoa,3D1HX@33213|Bilateria,41ZNG@6656|Arthropoda 33208|Metazoa S oxidation-reduction process - - - - - - - - - - - - - k59_2331_1 400682.PAC_15712048 4.06e-07 59.3 COG2110@1|root,KOG2633@2759|Eukaryota,39MRM@33154|Opisthokonta,3CPBH@33208|Metazoa 33208|Metazoa O Macro domain - - 2.3.2.27 ko:K06058 ko04330,map04330 - - - ko00000,ko00001,ko01000,ko04121 - - - Macro,zf-RING_2 k59_35288_1 99598.Cal7507_5168 2.42e-31 122.0 COG0337@1|root,COG0337@2|Bacteria,1G03C@1117|Cyanobacteria,1HIJQ@1161|Nostocales 1117|Cyanobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_35288_2 330214.NIDE1354 9.35e-20 87.4 COG2203@1|root,COG3605@1|root,COG2203@2|Bacteria,COG3605@2|Bacteria,3J0XQ@40117|Nitrospirae 40117|Nitrospirae T ANTAR - - - - - - - - - - - - ANTAR,GAF_2 k59_35310_1 1121935.AQXX01000138_gene3142 8.5e-33 126.0 COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,1RP5F@1236|Gammaproteobacteria,1XH2X@135619|Oceanospirillales 135619|Oceanospirillales E aminoacyl-histidine dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_28197_1 458817.Shal_3882 2.84e-11 59.3 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,2QCKB@267890|Shewanellaceae 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03116,ko:K03425 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_28197_2 1385420.FRA_35c07480 2.92e-32 116.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,4610M@72273|Thiotrichales 72273|Thiotrichales FG Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_28197_3 717774.Marme_3473 8.02e-17 74.3 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1XKTK@135619|Oceanospirillales 135619|Oceanospirillales E Phosphoribosyl-ATP hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_24807_1 31234.CRE22625 1.15e-36 147.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3DKXU@33213|Bilateria,40IDJ@6231|Nematoda,1M1NS@119089|Chromadorea,40U7W@6236|Rhabditida 33208|Metazoa B K02A2.6-like - - - - - - - - - - - - Asp_protease_2,Glycoprotein_B,RVT_1,Retrotrans_gag,gag-asp_proteas,rve k59_7317_1 583345.Mmol_0644 8.14e-39 141.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KMQE@206350|Nitrosomonadales 206350|Nitrosomonadales T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_40468_1 7719.XP_009858221.1 1.22e-32 129.0 2CQJ9@1|root,2R501@2759|Eukaryota,39VPP@33154|Opisthokonta,3BH26@33208|Metazoa,3D1HX@33213|Bilateria,48CQC@7711|Chordata 33208|Metazoa S oxidation-reduction process - - - - - - - - - - - - - k59_52701_1 7091.BGIBMGA006564-TA 4.04e-38 135.0 2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - - k59_9064_2 311424.DhcVS_1162 7.16e-32 127.0 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2G6ND@200795|Chloroflexi,34CT3@301297|Dehalococcoidia 301297|Dehalococcoidia KT diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,HD,HisKA_7TM k59_17822_1 6669.EFX63656 1.01e-17 89.7 KOG1075@1|root,KOG1075@2759|Eukaryota,39MTI@33154|Opisthokonta,3CPD9@33208|Metazoa,3E5HV@33213|Bilateria,42AJ0@6656|Arthropoda 2759|Eukaryota S Endonuclease-reverse transcriptase - - - - - - - - - - - - Exo_endo_phos_2 k59_49364_1 330214.NIDE3295 8.24e-08 52.8 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c ccoP - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrom_C,Cytochrome_CBB3,FixO k59_49364_2 330214.NIDE3294 7.91e-68 215.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_47545_1 330214.NIDE4178 1e-117 343.0 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase k59_40473_1 177439.DP0656 1.53e-49 172.0 COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,42MNT@68525|delta/epsilon subdivisions,2WJZS@28221|Deltaproteobacteria,2MN6F@213118|Desulfobacterales 28221|Deltaproteobacteria I serine threonine protein kinase - - - - - - - - - - - - - k59_42194_1 243160.BMA1789 5.8e-13 65.1 2DRVE@1|root,33D8G@2|Bacteria,1P1ND@1224|Proteobacteria,2W3YJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_483_1 448385.sce6597 3.54e-21 91.3 2E5WH@1|root,330KI@2|Bacteria,1QAVR@1224|Proteobacteria,435BU@68525|delta/epsilon subdivisions,2WZPC@28221|Deltaproteobacteria,2Z2GK@29|Myxococcales 28221|Deltaproteobacteria J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_19489_1 640081.Dsui_0035 1.65e-26 110.0 COG0666@1|root,COG0666@2|Bacteria,1R76J@1224|Proteobacteria,2VP42@28216|Betaproteobacteria,2KV0E@206389|Rhodocyclales 206389|Rhodocyclales S Ankyrin repeat - - - - - - - - - - - - Ank_4 k59_2400_1 303518.XP_005755538.1 1.5e-106 352.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3C0YC@33208|Metazoa,3DH14@33213|Bilateria,48RUJ@7711|Chordata,49N81@7742|Vertebrata,4A97P@7898|Actinopterygii 33208|Metazoa S RNA-directed DNA polymerase from mobile element jockey-like - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_14477_1 7091.BGIBMGA012290-TA 1.06e-25 112.0 2EMJ6@1|root,2SR73@2759|Eukaryota,3APM7@33154|Opisthokonta,3C35F@33208|Metazoa,3DI2R@33213|Bilateria,4234V@6656|Arthropoda,3SPU5@50557|Insecta,44A1S@7088|Lepidoptera 33208|Metazoa S Conserved hypothetical protein - - - - - - - - - - - - WW k59_498_1 330214.NIDE3973 5.33e-105 305.0 COG1945@1|root,COG1945@2|Bacteria 2|Bacteria I arginine decarboxylase activity pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_38706_1 35754.JNYJ01000072_gene2532 8.41e-159 457.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4D964@85008|Micromonosporales 201174|Actinobacteria L Transposase, Mutator family - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_43930_1 322710.Avin_32730 3.55e-35 129.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_504_1 7070.TC006914-PA 1.22e-63 224.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SQBU@50557|Insecta 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_49396_1 13249.RPRC009596-PA 2.6e-14 66.6 2D0S9@1|root,2SF7C@2759|Eukaryota,3ADAJ@33154|Opisthokonta,3BVN4@33208|Metazoa,3DJPE@33213|Bilateria,423Y2@6656|Arthropoda 33208|Metazoa - - - - - - - - - - - - - - - k59_42215_1 7029.ACYPI070551-PA 6.64e-42 161.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SQBU@50557|Insecta,3ECEX@33342|Paraneoptera 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_31932_1 283699.D172_1341 1.71e-96 293.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,2Q0GB@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB2 - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheD,Response_reg k59_7348_1 323848.Nmul_A2708 7.57e-75 230.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,372Q7@32003|Nitrosomonadales 28216|Betaproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_39267_2 546273.VEIDISOL_00573 5.69e-25 106.0 COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,4H2CY@909932|Negativicutes 909932|Negativicutes F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_28741_1 1120966.AUBU01000013_gene510 2.52e-07 58.5 COG2911@1|root,COG2982@1|root,COG3209@1|root,COG3210@1|root,COG2911@2|Bacteria,COG2982@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,4NUIW@976|Bacteroidetes 976|Bacteroidetes M COG3209 Rhs family protein - - - - - - - - - - - - CUB k59_48240_1 95619.PM1_0226545 2.51e-67 224.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_46329_2 240302.BN982_00209 1.7e-49 178.0 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,4HCNN@91061|Bacilli 91061|Bacilli L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_46329_6 320836.Q4ZD45_9CAUD 8.95e-21 102.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_51698_1 1123034.JMKP01000008_gene480 3.35e-60 196.0 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,1RMFD@1236|Gammaproteobacteria,3NJE5@468|Moraxellaceae 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_25471_1 1288826.MSNKSG1_05341 8.04e-22 94.4 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,4644T@72275|Alteromonadaceae 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_25471_2 644801.Psest_2258 9.43e-57 182.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1Z17H@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 CDP-OH_P_transf k59_46335_1 6087.XP_004211536.1 7.09e-50 185.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_46339_1 693746.OBV_35100 8.83e-58 193.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_50026_2 523791.Kkor_0557 2.11e-07 51.2 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1XHFA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_53462_1 1397528.Q671_08630 1.09e-36 137.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XNSE@135619|Oceanospirillales 135619|Oceanospirillales L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_11593_1 3750.XP_008354068.1 7.45e-83 281.0 KOG1075@1|root,KOG1075@2759|Eukaryota,37RKK@33090|Viridiplantae,3GFFM@35493|Streptophyta 35493|Streptophyta S 2S seed storage protein 5-like - - - - - - - - - - - - RVT_1,Tryp_alpha_amyl k59_3410_2 1033802.SSPSH_003251 4.59e-06 51.6 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU COG4968 Tfp pilus assembly protein PilE pilE - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_50045_1 748727.CLJU_c00400 3.65e-13 76.6 COG3953@1|root,COG5283@1|root,COG3953@2|Bacteria,COG5283@2|Bacteria,1VAT4@1239|Firmicutes,24H6B@186801|Clostridia,36IGP@31979|Clostridiaceae 186801|Clostridia D Transglycosylase SLT domain - - - - - - - - - - - - PhageMin_Tail,SLT k59_25496_1 864702.OsccyDRAFT_4158 1.16e-22 103.0 COG3264@1|root,COG3264@2|Bacteria,1G09S@1117|Cyanobacteria,1H93J@1150|Oscillatoriales 1117|Cyanobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_51723_1 330214.NIDE3623 2.95e-106 313.0 COG0656@1|root,COG0656@2|Bacteria 2|Bacteria S aldo-keto reductase (NADP) activity ytbE - - - - - - - - - - - Aldo_ket_red,DUF4157 k59_1269_1 357808.RoseRS_4095 5.94e-34 128.0 2DMC8@1|root,32J63@2|Bacteria 357808.RoseRS_4095|- L each copy contains a frameshift at the sequence CCCCCCTTTTT and 7 copies of repeat with repeat unit SCEEP - - - - - - - - - - - - - k59_1269_2 870187.Thini_0434 1.23e-39 143.0 COG3293@1|root,2ZJP3@2|Bacteria,1N918@1224|Proteobacteria,1T83V@1236|Gammaproteobacteria,463DF@72273|Thiotrichales 72273|Thiotrichales L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DDE_Tnp_4 k59_44496_1 1229909.NSED_09935 1.06e-82 249.0 COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_4543_1 243160.BMA2154 1.15e-22 96.3 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJM2@28216|Betaproteobacteria,1K3CW@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_44502_1 1499686.BN1079_02149 4.49e-13 73.9 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain pleD - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_24045_1 67315.JOBD01000023_gene222 1.32e-13 70.5 COG1028@1|root,COG1028@2|Bacteria,2GMWG@201174|Actinobacteria 201174|Actinobacteria IQ reductase phbB - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_24045_2 765912.Thimo_0853 1.35e-22 99.8 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1RZ37@1236|Gammaproteobacteria,1WX58@135613|Chromatiales 135613|Chromatiales T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_9679_1 857087.Metme_2492 2.82e-74 239.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1XG8U@135618|Methylococcales 135618|Methylococcales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_55093_1 330214.NIDE2582 3.5e-133 412.0 COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae 40117|Nitrospirae L DNA-directed DNA polymerase - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_6496_1 177437.HRM2_36780 3.64e-74 240.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_42824_1 7668.SPU_018293-tr 3.37e-17 91.3 KOG1075@1|root,KOG1075@2759|Eukaryota 7668.SPU_018293-tr|- E Ribonuclease H protein - - - - - - - - - - - - - k59_36168_1 330214.NIDE2073 8.78e-107 327.0 COG1389@1|root,COG1389@2|Bacteria 2|Bacteria L DNA topoisomerase II activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,HATPase_c_3,Topo-VIb_trans k59_28809_1 1298867.AUES01000051_gene4511 3.36e-15 81.3 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_22100_1 330214.NIDE0777 7.45e-37 137.0 COG1459@1|root,COG1459@2|Bacteria,3J0HZ@40117|Nitrospirae 40117|Nitrospirae U Type II secretion system (T2SS), protein F - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_9702_1 251221.35212193 8.21e-62 192.0 COG3293@1|root,COG3293@2|Bacteria,1G7GI@1117|Cyanobacteria 1117|Cyanobacteria L similarity to GB CAD86359.1 - - - - - - - - - - - - DUF4096 k59_32833_1 7668.SPU_024292-tr 1.17e-08 62.8 KOG3609@1|root,KOG3609@2759|Eukaryota,3AIBK@33154|Opisthokonta,3BXXP@33208|Metazoa,3DDTB@33213|Bilateria 33208|Metazoa PT Ion transport protein - - - - - - - - - - - - Ion_trans k59_55115_1 330214.NIDE3974 7.46e-30 116.0 COG1012@1|root,COG1012@2|Bacteria,3J0YN@40117|Nitrospirae 40117|Nitrospirae C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_42854_1 448385.sce4158 3.53e-56 190.0 COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,430KD@68525|delta/epsilon subdivisions,2WVSS@28221|Deltaproteobacteria,2YZ09@29|Myxococcales 28221|Deltaproteobacteria L High confidence in function and specificity - - - - - - - - - - - - DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_16837_2 1175654.A0A0S0N8B5_9CAUD 6.66e-92 278.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales,4QKRA@10699|Siphoviridae 10699|Siphoviridae S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_34589_1 7897.ENSLACP00000003684 2.09e-38 135.0 2DGIP@1|root,2S5UP@2759|Eukaryota,3A5XI@33154|Opisthokonta,3BT0Z@33208|Metazoa,3D12G@33213|Bilateria,48BUS@7711|Chordata,497VV@7742|Vertebrata 33208|Metazoa S FLJ37770-like GVQW3 - - - - - - - - - - - - k59_39359_1 7668.SPU_001414-tr 2.14e-12 70.5 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria 33208|Metazoa E K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2 k59_34592_1 7029.ACYPI005051-PA 5.94e-34 130.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera 33208|Metazoa S Endonuclease-reverse transcriptase - - - ko:K10443 - - - - ko00000,ko04121 - - - Exo_endo_phos_2,RNase_H,RVT_1 k59_13628_1 8083.ENSXMAP00000019927 5.21e-13 76.3 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49ADZ@7742|Vertebrata,4A4QB@7898|Actinopterygii 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_25560_1 6669.EFX74049 7.74e-26 112.0 2ERZU@1|root,2SUNW@2759|Eukaryota,39MNV@33154|Opisthokonta,3C27Z@33208|Metazoa,3DI2Q@33213|Bilateria,423AX@6656|Arthropoda 33208|Metazoa - - - - - - - - - - - - - - Exo_endo_phos,Exo_endo_phos_2 k59_36213_2 1121447.JONL01000001_gene565 1.89e-20 94.7 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,42YKK@68525|delta/epsilon subdivisions,2WUDS@28221|Deltaproteobacteria,2M8E7@213115|Desulfovibrionales 28221|Deltaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_32865_1 8090.ENSORLP00000018766 3.01e-12 69.3 2EWDT@1|root,2SY87@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_34608_1 330214.NIDE3315 1.7e-88 271.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - Big_3_2,Cu_amine_oxidN1,F5_F8_type_C,IgGFc_binding,PKD k59_24121_1 27923.ML070236a-PA 7.09e-46 171.0 2EJ6F@1|root,2SPEP@2759|Eukaryota,3AM82@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - - k59_15027_1 330214.NIDE0403 1.53e-51 179.0 COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_15027_2 1032480.MLP_17100 3.8e-08 54.3 COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4DNG8@85009|Propionibacteriales 201174|Actinobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_24415_1 83406.HDN1F_22720 2.53e-111 334.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1J5ZS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P the major facilitator superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_36603_1 6087.XP_004212792.1 3.9e-66 213.0 2D12R@1|root,2SGHE@2759|Eukaryota,39MAD@33154|Opisthokonta,3CNXH@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - Pox_A32 k59_40089_1 1432056.X781_9680 4.44e-34 135.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RN4X@1236|Gammaproteobacteria,1Y7V8@135625|Pasteurellales 135625|Pasteurellales L Bacterial DNA topoisomeraes I ATP-binding domain topB1 - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_15691_2 102129.Lepto7375DRAFT_8161 8.39e-05 48.9 COG2274@1|root,COG2274@2|Bacteria,1FZZ2@1117|Cyanobacteria,1H760@1150|Oscillatoriales 1117|Cyanobacteria V N-terminal double-glycine peptidase domain hetC - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding k59_45321_2 448385.sce6101 2.26e-18 83.6 COG3436@1|root,COG3436@2|Bacteria,1PXYK@1224|Proteobacteria,43DZ7@68525|delta/epsilon subdivisions,2WZ9A@28221|Deltaproteobacteria,2Z1MK@29|Myxococcales 28221|Deltaproteobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_22698_1 330214.NIDE0414 9.44e-63 200.0 COG4244@1|root,COG4244@2|Bacteria 2|Bacteria E Membrane - - - - - - - - - - - - Cyt-b5,DUF2231,Fn3_assoc,PSCyt1,PSCyt2,PSD1 k59_38357_1 436308.Nmar_1508 6.82e-29 106.0 COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein rps15 - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13_N,Ribosomal_S15 k59_38357_2 1229909.NSED_08290 5.43e-62 191.0 arCOG10587@1|root,arCOG10587@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_33144_1 10224.XP_006821682.1 2.65e-54 189.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria 33208|Metazoa E K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,rve,zf-CCHC k59_43598_2 1195236.CTER_2369 1.78e-23 100.0 COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,3WI84@541000|Ruminococcaceae 186801|Clostridia M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpA1 - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_47097_1 330214.NIDE4089 6.69e-106 315.0 COG1702@1|root,COG1702@2|Bacteria,3J0AD@40117|Nitrospirae 40117|Nitrospirae T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_22725_1 8479.XP_008164575.1 9.4e-14 77.0 2CMEU@1|root,2QQ5W@2759|Eukaryota,38E7N@33154|Opisthokonta,3BF2D@33208|Metazoa,3CTMS@33213|Bilateria,480S2@7711|Chordata,48X2Z@7742|Vertebrata,4CMIQ@8459|Testudines 33208|Metazoa T Zona pellucida (ZP) domain Cuzd1 - - ko:K13912 ko04970,map04970 - - - ko00000,ko00001 - - - CUB,SRCR,Zona_pellucida k59_19205_1 330214.NIDE4110 4.65e-77 246.0 COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae 40117|Nitrospirae E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_41859_2 31234.CRE13136 1.17e-22 106.0 2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria,40FF9@6231|Nematoda,1KYD3@119089|Chromadorea,413MN@6236|Rhabditida 33208|Metazoa S DNA polymerase type B, organellar and viral - - - - - - - - - - - - DNA_pol_B_2,Rho_N k59_15732_1 1123393.KB891326_gene136 5.42e-86 271.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,1KSIG@119069|Hydrogenophilales 119069|Hydrogenophilales C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases k59_38383_1 395495.Lcho_1825 2.08e-16 77.8 COG5501@1|root,COG5501@2|Bacteria,1RBHP@1224|Proteobacteria,2VR7Y@28216|Betaproteobacteria,1KJNS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Sulphur oxidation protein SoxZ - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,SoxZ k59_38383_2 497321.C664_19883 1.81e-32 122.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VN1Z@28216|Betaproteobacteria,2KXKA@206389|Rhodocyclales 206389|Rhodocyclales S COG0491 Zn-dependent hydrolases, including glyoxylases - - - ko:K01138 - - - - ko00000,ko01000 - - - Lactamase_B k59_14007_1 96561.Dole_2580 4.28e-24 100.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MHY2@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_8761_1 945713.IALB_2980 4.37e-24 96.7 2E5WH@1|root,330KI@2|Bacteria 2|Bacteria J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_8761_2 395492.Rleg2_1002 6.74e-29 112.0 COG3293@1|root,COG3293@2|Bacteria,1REX3@1224|Proteobacteria,2U89Y@28211|Alphaproteobacteria,4BM8S@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_52334_1 6087.XP_004207470.1 2.13e-51 184.0 2CNBX@1|root,2QV3V@2759|Eukaryota,39W09@33154|Opisthokonta,3BH5J@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - - k59_52334_2 7029.ACYPI46593-PA 9.96e-11 66.2 2D3M8@1|root,2SS02@2759|Eukaryota,3ANR4@33154|Opisthokonta,3C1MX@33208|Metazoa,3DH7H@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_10523_1 1123229.AUBC01000040_gene3838 3.3e-63 210.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2TVA2@28211|Alphaproteobacteria,3JRH7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - Sigma70_r4_2,rve k59_3552_1 203908.EGF97697 6.89e-08 58.2 2DZCK@1|root,2S6X3@2759|Eukaryota,3A5SR@33154|Opisthokonta,3P5B4@4751|Fungi,3V2GU@5204|Basidiomycota 4751|Fungi - - - - - - - - - - - - - - - k59_36638_1 1247649.D560_3828 2.48e-144 415.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2VN7F@28216|Betaproteobacteria,3T7ZU@506|Alcaligenaceae 28216|Betaproteobacteria L Transposase for IS481 element - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 k59_5317_1 330214.NIDE1308 2.34e-117 355.0 COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_82_2 69293.ENSGACP00000000095 4.27e-26 106.0 2CYQC@1|root,2S5N3@2759|Eukaryota,3A64I@33154|Opisthokonta,3BSSI@33208|Metazoa,3D9P4@33213|Bilateria,48GDK@7711|Chordata,49D51@7742|Vertebrata,4A4P7@7898|Actinopterygii 33208|Metazoa - - - - - - - - - - - - - - - k59_22778_1 497965.Cyan7822_4932 3.24e-47 172.0 COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1G00D@1117|Cyanobacteria,3KH66@43988|Cyanothece 1117|Cyanobacteria PT Sodium hydrogen exchanger nhaS5 - - - - - - - - - - - Na_H_Exchanger,Usp k59_41899_1 436308.Nmar_1793 2.28e-76 239.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_15772_1 76114.ebA4291 1.57e-38 139.0 COG2227@1|root,COG2227@2|Bacteria,1QVIA@1224|Proteobacteria,2VWHZ@28216|Betaproteobacteria 28216|Betaproteobacteria H ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_17508_2 1163617.SCD_n01069 8.51e-65 224.0 COG3378@1|root,COG3378@2|Bacteria,1QVIS@1224|Proteobacteria,2VPDW@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage plasmid primase, P4 family domain protein - - - ko:K06919 - - - - ko00000 - - - - k59_34952_2 32507.XP_006808473.1 0.000747 49.3 COG2801@1|root,KOG0017@2759|Eukaryota,3AIZM@33154|Opisthokonta,3BXSA@33208|Metazoa,3DF2V@33213|Bilateria,48JZ9@7711|Chordata,49GQD@7742|Vertebrata 33208|Metazoa L Integrase core domain - - - - - - - - - - - - rve k59_27954_1 1232410.KI421418_gene2315 3.8e-71 222.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,43SDM@69541|Desulfuromonadales 28221|Deltaproteobacteria M Prolipoprotein diacylglyceryl transferase lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_22790_1 330214.NIDE1016 7.87e-85 269.0 COG0768@1|root,COG0768@2|Bacteria,3J0FY@40117|Nitrospirae 40117|Nitrospirae M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_24510_2 194699.PORTL_BPBPP 1.94e-112 347.0 4QCM5@10239|Viruses,4QVZY@35237|dsDNA viruses no RNA stage,4QQFH@28883|Caudovirales,4QNDH@10744|Podoviridae 10744|Podoviridae S Bacteriophage head to tail connecting protein - GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019028,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0032991,GO:0044403,GO:0044419,GO:0044423,GO:0046798,GO:0051704 - - - - - - - - - - - k59_54114_1 7425.NV12212-PA 9.23e-28 116.0 2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria,41V8V@6656|Arthropoda,3SQAF@50557|Insecta,46JIB@7399|Hymenoptera 33208|Metazoa S DNA polymerase type B, organellar and viral - - - - - - - - - - - - DNA_pol_B_2 k59_40177_1 6087.XP_004211536.1 1.6e-39 150.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta 33154|Opisthokonta - - - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_17520_1 1123508.JH636454_gene5742 4.91e-16 78.6 COG3728@1|root,COG3728@2|Bacteria,2J4BI@203682|Planctomycetes 203682|Planctomycetes L Terminase small subunit - - - - - - - - - - - - Terminase_2 k59_17520_2 1524880.A0A076G6J2_9VIRU 6.03e-60 202.0 4QD9Y@10239|Viruses 10239|Viruses S Pfam:Terminase_6C - - - - - - - - - - - - - k59_40180_1 349521.HCH_04416 1.71e-115 347.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_52374_2 269797.Mbar_A0500 2.74e-16 81.3 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia 224756|Methanomicrobia P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_21017_1 330214.NIDE2654 6.44e-135 417.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,3J0WW@40117|Nitrospirae 40117|Nitrospirae T Two component signalling adaptor domain - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_33278_2 553385.JEMF01000016_gene522 1.49e-07 52.4 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1XHJI@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_10574_1 10224.XP_006813913.1 0.000836 47.4 COG2801@1|root,KOG2605@1|root,KOG0017@2759|Eukaryota,KOG2605@2759|Eukaryota 2759|Eukaryota G thiol-dependent ubiquitin-specific protease activity - - 3.2.1.25,3.4.19.12 ko:K01192,ko:K12655,ko:K15332,ko:K21444 ko00511,ko04142,ko04622,map00511,map04142,map04622 - - - ko00000,ko00001,ko01000,ko01002,ko03016,ko03019,ko04121 - - - KH_1,OTU k59_22809_2 1298593.TOL_0503 1.96e-13 79.7 COG4228@1|root,COG4228@2|Bacteria,1R4HU@1224|Proteobacteria,1RPRY@1236|Gammaproteobacteria,1XQ73@135619|Oceanospirillales 135619|Oceanospirillales S DNA circularisation protein N-terminus - - - - - - - - - - - - DNA_circ_N k59_22809_3 1517681.HW45_20050 4.29e-31 128.0 COG4379@1|root,COG4379@2|Bacteria,1MX68@1224|Proteobacteria,1RYCD@1236|Gammaproteobacteria,1XX6Q@135623|Vibrionales 135623|Vibrionales S tail protein - - - - - - - - - - - - Phage_GPD k59_5365_1 930166.CD58_28900 1.03e-47 159.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186 Pribosyltran k59_5365_2 1298593.TOL_0206 1.63e-31 116.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1XJ6Q@135619|Oceanospirillales 135619|Oceanospirillales D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA - - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_1929_1 330214.NIDE1834 2.67e-77 243.0 COG3547@1|root,COG3547@2|Bacteria,3J17W@40117|Nitrospirae 40117|Nitrospirae L hmm pf02371 - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_43675_1 330214.NIDE2551 7.99e-136 402.0 COG0481@1|root,COG0481@2|Bacteria,3J0D1@40117|Nitrospirae 40117|Nitrospirae M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_43678_1 1207076.ALAT01000230_gene681 1.33e-61 194.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1Z091@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0155,iYL1228.KPN_03757 Ribul_P_3_epim k59_31538_2 330214.NIDE1278 1.89e-66 209.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - yxlG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_14109_1 330214.NIDE1631 1.21e-128 370.0 COG0752@1|root,COG0752@2|Bacteria,3J0F5@40117|Nitrospirae 40117|Nitrospirae J Glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_27992_2 7668.SPU_017650-tr 1.85e-32 125.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D8IP@33213|Bilateria 33208|Metazoa H Integrase core domain - - - - - - - - - - - - Chromo,rve k59_6743_2 2340.JV46_07780 1.03e-13 66.6 COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C reductase beta subunit aprB - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4,Fer4_9 k59_18785_1 76114.ebA3972 8.7e-06 47.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,2KW3W@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_18785_2 1395571.TMS3_0123475 6.19e-37 128.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_47592_1 1123054.KB907708_gene2056 1.16e-28 119.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WW1B@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9,Response_reg k59_10962_1 6087.XP_004213372.1 4.39e-20 98.2 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa 33208|Metazoa G Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_52750_1 6087.XP_002168505.2 5.92e-44 169.0 COG0515@1|root,KOG4250@2759|Eukaryota 2759|Eukaryota KLT IkappaB kinase activity IKK1 GO:0001666,GO:0002225,GO:0002230,GO:0002252,GO:0002376,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002759,GO:0002760,GO:0002784,GO:0002786,GO:0002803,GO:0002805,GO:0002807,GO:0002808,GO:0002831,GO:0002833,GO:0002920,GO:0002922,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006963,GO:0007154,GO:0007165,GO:0007166,GO:0007249,GO:0007252,GO:0008063,GO:0008150,GO:0008152,GO:0008384,GO:0008385,GO:0009056,GO:0009057,GO:0009605,GO:0009607,GO:0009615,GO:0009617,GO:0009628,GO:0009653,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018105,GO:0018193,GO:0018209,GO:0019219,GO:0019221,GO:0019222,GO:0019538,GO:0019730,GO:0019731,GO:0023051,GO:0023052,GO:0023057,GO:0030163,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031347,GO:0031349,GO:0032101,GO:0032103,GO:0032502,GO:0032991,GO:0033209,GO:0033554,GO:0034097,GO:0034248,GO:0034250,GO:0034612,GO:0035556,GO:0036211,GO:0036293,GO:0036294,GO:0042221,GO:0042742,GO:0043170,GO:0043207,GO:0043412,GO:0043900,GO:0043902,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045088,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048856,GO:0050688,GO:0050691,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050829,GO:0050896,GO:0051090,GO:0051091,GO:0051092,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0060255,GO:0061057,GO:0061695,GO:0065007,GO:0065009,GO:0070482,GO:0070887,GO:0071310,GO:0071345,GO:0071356,GO:0071453,GO:0071456,GO:0071704,GO:0080090,GO:0080134,GO:0098542,GO:0140096,GO:1900424,GO:1900426,GO:1901222,GO:1901223,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1902531,GO:1902532,GO:1902554,GO:1902680,GO:1902911,GO:1903506,GO:1903508,GO:1990234,GO:2000112,GO:2001141 2.7.11.10 ko:K04467,ko:K07209 ko01523,ko04010,ko04014,ko04062,ko04064,ko04068,ko04150,ko04151,ko04210,ko04380,ko04620,ko04621,ko04622,ko04623,ko04624,ko04657,ko04658,ko04659,ko04660,ko04662,ko04668,ko04722,ko04910,ko04920,ko04930,ko04931,ko04932,ko05120,ko05131,ko05142,ko05145,ko05160,ko05161,ko05162,ko05164,ko05165,ko05166,ko05167,ko05168,ko05169,ko05200,ko05206,ko05212,ko05215,ko05220,ko05221,ko05222,ko05418,map01523,map04010,map04014,map04062,map04064,map04068,map04150,map04151,map04210,map04380,map04620,map04621,map04622,map04623,map04624,map04657,map04658,map04659,map04660,map04662,map04668,map04722,map04910,map04920,map04930,map04931,map04932,map05120,map05131,map05142,map05145,map05160,map05161,map05162,map05164,map05165,map05166,map05167,map05168,map05169,map05200,map05206,map05212,map05215,map05220,map05221,map05222,map05418 M00686 - - ko00000,ko00001,ko00002,ko01000,ko01001 - - - Pkinase k59_537_1 330214.NIDE3311 7.28e-109 322.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 k59_38741_1 7668.SPU_010393-tr 2.87e-36 142.0 COG1199@1|root,KOG1075@1|root,KOG1075@2759|Eukaryota,KOG1132@2759|Eukaryota,391E5@33154|Opisthokonta,3CJ6Y@33208|Metazoa,3DHJR@33213|Bilateria 2759|Eukaryota KL Reverse transcriptase (RNA-dependent DNA polymerase) - GO:0000018,GO:0000166,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006282,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0009987,GO:0010569,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0051276,GO:0060255,GO:0065007,GO:0070035,GO:0071103,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901363,GO:2000779,GO:2001020 3.6.4.12 ko:K11136 - - - - ko00000,ko01000,ko03032 - - - DEAD_2,Helicase_C_2,RVT_1 k59_40532_1 281687.CJA15137 2.98e-18 89.4 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3DKJZ@33213|Bilateria,40GWW@6231|Nematoda,1KZYW@119089|Chromadorea,412EV@6236|Rhabditida 33208|Metazoa K Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_49449_1 330214.NIDE0563 3.91e-61 202.0 COG1032@1|root,COG1032@2|Bacteria,3J0WM@40117|Nitrospirae 40117|Nitrospirae C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_49449_2 330214.NIDE0564 1.89e-92 276.0 COG0500@1|root,COG2226@2|Bacteria,3J0S6@40117|Nitrospirae 40117|Nitrospirae H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_54453_3 7425.NV24824-PA 5.18e-05 48.1 2D5JT@1|root,2SYTH@2759|Eukaryota,3ATQS@33154|Opisthokonta 7425.NV24824-PA|- - - - - - - - - - - - - - - - k59_5795_1 317619.ANKN01000132_gene3495 7.37e-13 69.3 COG0464@1|root,COG0464@2|Bacteria,1GBNX@1117|Cyanobacteria,1MKE0@1212|Prochloraceae 2|Bacteria O of the AAA - - - - - - - - - - - - AAA k59_21378_1 330214.NIDE1363 2.2e-120 355.0 COG0174@1|root,COG0174@2|Bacteria,3J0AS@40117|Nitrospirae 40117|Nitrospirae E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_16198_1 395495.Lcho_0013 6.88e-17 82.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,1KMKG@119065|unclassified Burkholderiales 28216|Betaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_54455_1 315456.RF_0975 2.49e-64 209.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TTHU@28211|Alphaproteobacteria,47G5U@766|Rickettsiales 766|Rickettsiales L Integrase core domain - - - - - - - - - - - - rve k59_17896_1 1333507.AUTQ01000111_gene1192 0.000301 48.1 COG1943@1|root,COG1943@2|Bacteria,1N28A@1224|Proteobacteria,1S9RC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DNA-binding - - - - - - - - - - - - Tnp_DNA_bind k59_23281_1 1229909.NSED_08450 2.41e-31 110.0 COG1145@1|root,arCOG00291@2157|Archaea,41SNB@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase - - - - - - - - - - - - Fer4 k59_23281_2 436308.Nmar_1538 1.87e-36 123.0 arCOG08782@1|root,arCOG08782@2157|Archaea,41SVH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_574_1 1636270.A0A0E3JI95_9CAUD 7.09e-09 60.1 4QBA2@10239|Viruses,4QPPI@28883|Caudovirales 28883|Caudovirales S Thymidylate synthase - - - - - - - - - - - - - k59_26716_1 7668.SPU_016918-tr 5.18e-28 117.0 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_30130_1 7955.ENSDARP00000109600 8.29e-40 146.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A5PS@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_2507_1 7070.TC001829-PA 2.56e-46 162.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D40D@33213|Bilateria,4222J@6656|Arthropoda,3SQHH@50557|Insecta 33208|Metazoa L transposition, RNA-mediated - - - - - - - - - - - - Chromo,rve k59_12777_1 1123487.KB892865_gene1375 6.45e-85 261.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,2KZJK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_45790_1 78245.Xaut_4003 5.25e-23 102.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_33861_1 999141.GME_18872 1.36e-60 202.0 COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,1RW45@1236|Gammaproteobacteria,1XNQX@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the TPP enzyme family - - 4.1.1.47 ko:K01608 ko00630,ko01100,map00630,map01100 - R00013 RC00899 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_24904_1 330214.NIDE0261 1.5e-25 100.0 COG0740@1|root,COG0740@2|Bacteria,3J0A3@40117|Nitrospirae 40117|Nitrospirae O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_24904_2 330214.NIDE0260 4.24e-133 387.0 COG1219@1|root,COG1219@2|Bacteria,3J0AM@40117|Nitrospirae 40117|Nitrospirae O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_19566_2 1298858.AUEL01000009_gene4339 2.11e-20 91.7 COG4397@1|root,COG4397@2|Bacteria,1MWX8@1224|Proteobacteria,2U0B4@28211|Alphaproteobacteria,43N8G@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Mu-like prophage major head subunit gpT - - - - - - - - - - - - Mu-like_gpT k59_5821_1 1134445.AJJM01000029_gene4516 4.98e-66 213.0 COG3239@1|root,COG3239@2|Bacteria,2IDCW@201174|Actinobacteria 201174|Actinobacteria I Fatty acid desaturase - - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_9170_1 330214.NIDE1514 8.53e-101 306.0 COG0312@1|root,COG0312@2|Bacteria,3J0F9@40117|Nitrospirae 40117|Nitrospirae S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_51156_1 7029.ACYPI067270-PA 3.41e-45 166.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera 33208|Metazoa O K02A2.6-like - - - - - - - - - - - - Baculo_F,RVT_1,rve k59_44020_1 296591.Bpro_4152 1.09e-53 184.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,4AC6C@80864|Comamonadaceae 28216|Betaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_16239_1 330214.NIDE3256 4.03e-155 443.0 COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae 2|Bacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ddhB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Fer4_11 k59_26764_1 1449350.OCH239_07110 4.91e-88 272.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,4KNPU@93682|Roseivivax 28211|Alphaproteobacteria P Nitrate ABC transporter substrate-binding protein nrtA - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_2573_1 7070.TC006914-PA 1.8e-21 98.2 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SQBU@50557|Insecta 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_52839_1 330214.NIDE2745 2.29e-30 117.0 COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_52839_2 398767.Glov_0504 1.39e-21 92.4 COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43TXA@69541|Desulfuromonadales 28221|Deltaproteobacteria O PFAM cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_47704_1 13249.RPRC004498-PA 1.79e-167 484.0 2CNBX@1|root,2QV3V@2759|Eukaryota,39W09@33154|Opisthokonta,3BH5J@33208|Metazoa,3E62V@33213|Bilateria,42B7K@6656|Arthropoda,3T0MX@50557|Insecta,3EEBZ@33342|Paraneoptera 33208|Metazoa - - - - - - - - - - - - - - - k59_16264_1 98439.AJLL01000068_gene1550 9.05e-17 82.0 COG0030@1|root,COG0030@2|Bacteria,1G03N@1117|Cyanobacteria,1JJT1@1189|Stigonemataceae 1117|Cyanobacteria J Ribosomal RNA adenine dimethylases ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_49535_1 1298867.AUES01000051_gene4511 5.38e-10 66.6 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_44042_1 1120963.KB894495_gene3263 1.4e-06 52.8 COG2837@1|root,COG2837@2|Bacteria,1MWDD@1224|Proteobacteria,1RMZJ@1236|Gammaproteobacteria,2Q0B0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P iron-dependent peroxidase - - - ko:K07223 - - - - ko00000 - - - Dyp_perox k59_44045_1 1268237.G114_11520 4.87e-29 105.0 COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,1S7UR@1236|Gammaproteobacteria,1Y4GF@135624|Aeromonadales 135624|Aeromonadales S Putative member of DMT superfamily (DUF486) - - - ko:K09922 - - - - ko00000 - - - DMT_6 k59_44045_2 1122599.AUGR01000017_gene2951 2.55e-45 160.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1XH34@135619|Oceanospirillales 135619|Oceanospirillales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_40614_1 56780.SYN_03174 7.71e-65 212.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MRTS@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_30184_1 7425.NV18855-PA 3.68e-30 127.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_47725_1 102129.Lepto7375DRAFT_7553 1.82e-15 73.9 COG0736@1|root,COG0736@2|Bacteria,1G6YV@1117|Cyanobacteria,1HFS0@1150|Oscillatoriales 1117|Cyanobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_47725_2 1125863.JAFN01000001_gene2156 1.06e-14 74.7 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_47732_1 1144342.PMI40_03921 2.79e-16 84.7 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,4726Y@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_37078_1 1298593.TOL_2815 2.82e-74 236.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1XHND@135619|Oceanospirillales 135619|Oceanospirillales M COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_33952_1 436308.Nmar_0479 3.02e-83 258.0 COG0226@1|root,arCOG00213@2157|Archaea,41SXU@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM phosphate ABC transporter - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_12863_1 330214.NIDE0539 3.25e-99 310.0 COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae 40117|Nitrospirae D Ftsk_gamma ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_21464_1 330214.NIDE1362 1.47e-84 273.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.42,2.7.7.59,2.7.7.89 ko:K00982,ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_14696_1 1283300.ATXB01000001_gene1710 3.78e-51 177.0 COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,1RNIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Trehalose_PPase k59_38858_1 215358.XP_010745375.1 7.8e-18 88.2 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria 33208|Metazoa E K02A2.6-like - - - - - - - - - - - - Asp_protease_2,PNMA,RVT_1,rve k59_45859_1 7739.XP_002599454.1 1.17e-29 133.0 2CZKA@1|root,2SAS4@2759|Eukaryota 2759|Eukaryota S GIY-YIG catalytic domain - - - - - - - - - - - - GIY-YIG k59_674_1 330214.NIDE0638 1.87e-100 313.0 COG4772@1|root,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_17991_1 771875.Ferpe_1782 3.6e-07 53.1 COG0296@1|root,COG4945@1|root,COG0296@2|Bacteria,COG4945@2|Bacteria,2GC51@200918|Thermotogae 200918|Thermotogae G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - AMPK1_CBM,Glucodextran_C,Glyco_hydro_57 k59_36584_1 10658.DPOL_BPPRD 4.12e-46 169.0 4QAWD@10239|Viruses,4QVNG@35237|dsDNA viruses no RNA stage,4QHTW@10656|Tectiviridae 10656|Tectiviridae L DNA binding - GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_17144_1 330214.NIDE4105 7.61e-113 336.0 COG0215@1|root,COG0215@2|Bacteria,3J0CM@40117|Nitrospirae 40117|Nitrospirae J DALR_2 cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_29062_1 330214.NIDE0681 1.95e-112 336.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 40117|Nitrospirae M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_46795_1 1095769.CAHF01000011_gene2229 1.47e-12 70.9 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,473BV@75682|Oxalobacteraceae 28216|Betaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_46795_2 1288494.EBAPG3_700 1e-11 62.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,37315@32003|Nitrosomonadales 28216|Betaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_55468_1 667015.Bacsa_1644 9.72e-60 200.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,2FM3F@200643|Bacteroidia,4AMJG@815|Bacteroidaceae 976|Bacteroidetes M Psort location CytoplasmicMembrane, score 10.00 algI - - - - - - - - - - - MBOAT k59_41653_2 393595.ABO_0569 1.87e-11 63.5 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S4MG@1236|Gammaproteobacteria,1XKXV@135619|Oceanospirillales 135619|Oceanospirillales S hydrolase of the alpha beta superfamily - - - ko:K07018 - - - - ko00000 - - - Abhydrolase_1 k59_43372_1 326424.FRAAL6427 3e-20 96.3 COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ESAG@85013|Frankiales 201174|Actinobacteria S MMPL family - - - ko:K06994 - - - - ko00000 - - - MMPL k59_39841_1 36651.K9FA30 6.98e-30 123.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3NVKU@4751|Fungi,3QP1S@4890|Ascomycota,20NZ4@147545|Eurotiomycetes,3SEWR@5042|Eurotiales 4751|Fungi L gag-polyprotein putative aspartyl protease - GO:0000943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003887,GO:0003964,GO:0004518,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006508,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019538,GO:0032196,GO:0032197,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140096,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576 - ko:K07497 - - - - ko00000 - - - Peptidase_A2B,Peptidase_A2E,RVT_1,Retrotrans_gag,gag-asp_proteas,rve,zf-CCHC k59_41696_1 582744.Msip34_0154 5.49e-17 86.3 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,2KKSU@206350|Nitrosomonadales 206350|Nitrosomonadales H TonB dependent receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_45022_1 1333856.L686_01280 4.56e-63 208.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1YZQ3@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Magnesium chelatase, subunit comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_17356_2 330214.NIDE2657 1.18e-72 219.0 COG0745@1|root,COG0745@2|Bacteria,3J16K@40117|Nitrospirae 40117|Nitrospirae T cheY-homologous receiver domain - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_17356_3 330214.NIDE2656 5.76e-09 55.8 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis cheW2 - - ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW k59_17360_1 911239.CF149_22043 1.43e-54 178.0 COG1192@1|root,COG1192@2|Bacteria,1MWSE@1224|Proteobacteria,1RQ3X@1236|Gammaproteobacteria 1236|Gammaproteobacteria D COG1192 ATPases involved in chromosome partitioning XCC1889 - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_29282_1 330214.NIDE4143 3.07e-87 271.0 COG0421@1|root,COG0421@2|Bacteria 2|Bacteria E spermidine synthase activity speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Spermine_synth k59_43426_1 303518.XP_005755538.1 3.12e-34 135.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3C0YC@33208|Metazoa,3DH14@33213|Bilateria,48RUJ@7711|Chordata,49N81@7742|Vertebrata,4A97P@7898|Actinopterygii 33208|Metazoa S RNA-directed DNA polymerase from mobile element jockey-like - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_38116_1 330214.NIDE3952 2.58e-137 395.0 COG0022@1|root,COG0022@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor pdhB - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2753 Biotin_lipoyl,Transket_pyr,Transketolase_C k59_10264_1 1276756.AUEX01000007_gene1403 1.36e-34 120.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,4AECC@80864|Comamonadaceae 28216|Betaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_10264_2 105559.Nwat_2918 3.39e-36 134.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales 135613|Chromatiales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_45065_1 7668.SPU_027820-tr 1.39e-33 134.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria 33208|Metazoa E K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2 k59_43483_1 420324.KI911984_gene5121 1.37e-51 175.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,2U1TU@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_43519_2 349521.HCH_04798 1.14e-16 73.6 2EH9I@1|root,33B1E@2|Bacteria,1NH43@1224|Proteobacteria,1SD9Y@1236|Gammaproteobacteria,1XRG1@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2788) - - - - - - - - - - - - DUF2788 k59_41824_1 265072.Mfla_2129 1.31e-16 84.3 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_20767_1 1298593.TOL_0799 2.91e-82 254.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales 135619|Oceanospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_43548_1 1122599.AUGR01000001_gene366 2.8e-111 328.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1XHPM@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_10338_1 5147.XP_003349088.1 1.98e-08 60.8 COG2801@1|root,KOG0017@2759|Eukaryota,38V76@33154|Opisthokonta,3PWVS@4751|Fungi,3RFV9@4890|Ascomycota,21KCJ@147550|Sordariomycetes,3UE96@5139|Sordariales,3UPCP@5148|Sordariaceae 4751|Fungi L transposition, RNA-mediated - - - - - - - - - - - - - k59_39986_1 340177.Cag_0614 1.61e-14 78.6 COG1357@1|root,COG2931@1|root,COG3210@1|root,COG4625@1|root,COG1357@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis rhgB - 4.2.2.23 ko:K07004,ko:K18195 - - - - ko00000,ko01000 - PL4 - CBM-like,RhgB_N,fn3_3 k59_20789_1 330214.NIDE1303 5.29e-94 305.0 COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_45170_1 27923.ML143910a-PA 1.19e-25 117.0 KOG1075@1|root,KOG4357@1|root,KOG1075@2759|Eukaryota,KOG4357@2759|Eukaryota,38FUM@33154|Opisthokonta,3BKBY@33208|Metazoa 33208|Metazoa S positive regulation of skeletal muscle acetylcholine-gated channel clustering MESDC2 GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0005886,GO:0006457,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0006888,GO:0006897,GO:0006909,GO:0007498,GO:0008104,GO:0008150,GO:0009888,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016192,GO:0031974,GO:0032502,GO:0032879,GO:0032880,GO:0033036,GO:0034394,GO:0034613,GO:0042802,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045177,GO:0045184,GO:0046907,GO:0048193,GO:0048518,GO:0048522,GO:0048856,GO:0050750,GO:0050789,GO:0050794,GO:0050803,GO:0050807,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060341,GO:0065007,GO:0065008,GO:0070013,GO:0070325,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0098657,GO:0099175,GO:1901626,GO:1901628,GO:1903827,GO:1903829,GO:1903909,GO:1903911,GO:1904393,GO:1904395,GO:1904396,GO:1904398,GO:1905475,GO:1905477 - - - - - - - - - - Mesd k59_45175_1 1298593.TOL_0098 6.4e-29 120.0 COG3014@1|root,COG3014@2|Bacteria,1PD4S@1224|Proteobacteria,1RQ8Y@1236|Gammaproteobacteria,1XJIR@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09859 - - - - ko00000 - - - - k59_29478_1 1046714.AMRX01000001_gene1782 7.75e-121 355.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,4654K@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_29502_1 330214.NIDE4238 1.5e-117 358.0 COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae 40117|Nitrospirae J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 k59_45274_1 557598.LHK_02025 2.15e-13 72.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KQ95@206351|Neisseriales 206351|Neisseriales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_45274_2 667632.KB890217_gene4782 5.64e-25 99.8 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,1K3G6@119060|Burkholderiaceae 28216|Betaproteobacteria S ABC transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_29556_1 1282356.H045_18830 1.48e-74 231.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1YMZH@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria G catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4960 F_bP_aldolase k59_29556_2 998088.B565_0760 2.59e-20 88.6 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1Y4YT@135624|Aeromonadales 135624|Aeromonadales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_29620_2 83406.HDN1F_05460 5e-30 116.0 COG0489@1|root,COG0489@2|Bacteria,1QTGE@1224|Proteobacteria,1RXG3@1236|Gammaproteobacteria,1J6F1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Polysaccharide biosynthesis protein - - - - - - - - - - - - - k59_8031_1 27923.ML01764a-PA 1.06e-79 267.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_32883_1 1112204.GPOL_c07980 3.05e-37 137.0 COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4GB8J@85026|Gordoniaceae 201174|Actinobacteria S Histidine-specific methyltransferase, SAM-dependent egtD GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_18643_1 436308.Nmar_1794 7.77e-101 321.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_48364_1 35128.Thapsdraft1545 1.17e-116 345.0 28ISP@1|root,2QR3X@2759|Eukaryota,2XE5P@2836|Bacillariophyta 2836|Bacillariophyta P One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation - - - ko:K02705 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194 - - - PSII k59_46494_1 7668.SPU_023188-tr 5.69e-76 257.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_13691_1 1499967.BAYZ01000171_gene5556 7.87e-47 155.0 COG1490@1|root,COG1490@2|Bacteria,2NPJK@2323|unclassified Bacteria 2|Bacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_13691_2 1500890.JQNL01000001_gene1415 6.56e-13 68.9 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,1X5E0@135614|Xanthomonadales 135614|Xanthomonadales FL Methyltransferase - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N k59_44579_1 330214.NIDE1848 2.76e-62 197.0 COG3055@1|root,COG3055@2|Bacteria 2|Bacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - DUF3386,Kelch_1,Kelch_4,Kelch_5,fn3 k59_44579_2 330214.NIDE1847 5.77e-45 150.0 2DQ7E@1|root,3353C@2|Bacteria,3J1EM@40117|Nitrospirae 40117|Nitrospirae S Domain of unknown function (DUF5069) - - - - - - - - - - - - DUF5069 k59_15489_1 330214.NIDE0896 2.1e-145 424.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_36252_1 153948.NAL212_2437 8.48e-94 289.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VN3J@28216|Betaproteobacteria,373N2@32003|Nitrosomonadales 28216|Betaproteobacteria L Psort location Cytoplasmic, score 8.96 - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_32909_1 1229909.NSED_09030 4.29e-51 168.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_32912_1 1485544.JQKP01000014_gene1882 3.19e-69 224.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,44VJT@713636|Nitrosomonadales 28216|Betaproteobacteria P ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_27542_1 1298593.TOL_3597 4.94e-128 369.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XH7U@135619|Oceanospirillales 135619|Oceanospirillales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_27542_2 1396858.Q666_08905 6.7e-07 50.8 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,4677I@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_20207_1 6669.EFX63184 3.15e-18 89.4 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_48395_1 330214.NIDE0827 8.36e-100 301.0 COG0674@1|root,COG0674@2|Bacteria,3J105@40117|Nitrospirae 40117|Nitrospirae C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_4657_1 330214.NIDE0052 2.5e-82 252.0 COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria 2|Bacteria C electron transfer activity rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4,Fer4_13,Lactamase_B,Lactamase_B_5 k59_20213_2 330214.NIDE4027 1.72e-53 174.0 COG1076@1|root,COG1076@2|Bacteria,3J1CS@40117|Nitrospirae 40117|Nitrospirae O DnaJ molecular chaperone homology domain hscB - - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - - k59_1421_1 321327.CYA_2265 9.58e-40 147.0 COG1721@1|root,COG1721@2|Bacteria,1G15B@1117|Cyanobacteria,1GZR9@1129|Synechococcus 1117|Cyanobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_46533_1 1484157.PSNIH2_10985 6.23e-07 51.2 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1RNZC@1236|Gammaproteobacteria,3VXXN@53335|Pantoea 1236|Gammaproteobacteria S DUF218 domain ycbC GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564 - - - - - - - - - - DUF218 k59_46533_2 930169.B5T_00033 8.89e-38 140.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XIJT@135619|Oceanospirillales 135619|Oceanospirillales M gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_8101_1 1111479.AXAR01000011_gene2862 4.64e-18 81.6 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_48423_1 330214.NIDE0895 2.12e-29 110.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_44620_3 330214.NIDE1208 3.69e-34 120.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_53642_1 1395516.PMO01_20620 7.08e-23 102.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein ctpH - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_15537_1 1347368.HG964408_gene7055 2.25e-45 167.0 COG0457@1|root,COG0457@2|Bacteria,1TSH7@1239|Firmicutes,4HACN@91061|Bacilli,1ZBDH@1386|Bacillus 91061|Bacilli M Tetratricopeptide repeat - - - - - - - - - - - - - k59_48425_1 330214.NIDE2644 2.32e-58 192.0 COG0304@1|root,COG0304@2|Bacteria,3J0DH@40117|Nitrospirae 40117|Nitrospirae I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_44622_1 1454004.AW11_03085 1.68e-115 352.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_4682_2 998088.B565_0561 1.04e-79 245.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1Y3F2@135624|Aeromonadales 135624|Aeromonadales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_39441_2 316057.RPD_4374 1.66e-27 113.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQTN@28211|Alphaproteobacteria,3JUK1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase MA20_22730 - - - - - - - - - - - HAMP,HATPase_c,PAS_4,PAS_8 k59_25637_1 330214.NIDE0431 1.3e-38 143.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Big_5,VCBS k59_9814_1 1038860.AXAP01000015_gene2096 2.19e-65 220.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2U1CG@28211|Alphaproteobacteria,3JWWP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Glycosyl hydrolase family 65, C-terminal domain - - 2.4.1.64,5.4.2.6 ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 - R02727,R02728,R11310 RC00049,RC00408 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2 k59_41253_1 526227.Mesil_1694 4.67e-62 205.0 COG3328@1|root,COG3328@2|Bacteria,1WI20@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L COGs COG3328 Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_46565_1 1274374.CBLK010000003_gene3338 1.18e-07 53.9 COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,4HA1K@91061|Bacilli,26VVN@186822|Paenibacillaceae 91061|Bacilli J Catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_51915_1 686578.AFFX01000003_gene420 1.67e-41 147.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_51915_2 644801.Psest_3647 2.25e-47 160.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1Z0YK@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0422 IGPS k59_4705_1 330214.NIDE1759 8.44e-44 156.0 COG0778@1|root,COG0778@2|Bacteria,3J0XZ@40117|Nitrospirae 40117|Nitrospirae C Nitroreductase - - - - - - - - - - - - - k59_27609_1 400682.PAC_15702057 9.58e-27 113.0 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - RVT_1,zf-RVT k59_37702_1 2340.JV46_28950 7.22e-76 263.0 2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria 1224|Proteobacteria S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_18738_1 97139.C824_04459 1.61e-25 104.0 COG0012@1|root,COG0012@2|Bacteria,1UIBA@1239|Firmicutes,25EH3@186801|Clostridia,36S68@31979|Clostridiaceae 186801|Clostridia J GTP binding - - - - - - - - - - - - - k59_18738_2 933262.AXAM01000028_gene3328 2.9e-48 157.0 2DNS7@1|root,32YWC@2|Bacteria,1QU0X@1224|Proteobacteria,43CGA@68525|delta/epsilon subdivisions,2X7RB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_18743_1 1173026.Glo7428_2690 1.54e-68 218.0 COG1028@1|root,COG1028@2|Bacteria,1G67A@1117|Cyanobacteria 1117|Cyanobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_24250_1 330214.NIDE0837 1.5e-60 204.0 COG2838@1|root,COG2838@2|Bacteria 2|Bacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_24250_2 330214.NIDE0838 1.03e-32 119.0 COG1152@1|root,COG1152@2|Bacteria,3J11C@40117|Nitrospirae 40117|Nitrospirae C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - - k59_13839_1 1469613.JT55_19470 4.39e-27 103.0 COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,3FEDB@34008|Rhodovulum 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - ko:K07492 - - - - ko00000 - - - DUF4096 k59_33005_1 1459636.NTE_01609 4.16e-48 160.0 COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188,ko:K09866 ko04962,ko04976,map04962,map04976 - - - ko00000,ko00001,ko02000 1.A.8 - - MIP k59_33005_2 1379698.RBG1_1C00001G0651 8.85e-06 46.2 COG2406@1|root,COG2406@2|Bacteria,2NS0E@2323|unclassified Bacteria 2|Bacteria S Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_46595_2 330214.NIDE3269 6.89e-72 229.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Cytochrome_C554 k59_9848_1 330214.NIDE0232 1.11e-106 332.0 COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae 2|Bacteria C Molydopterin dinucleotide binding domain hcnA - 1.4.99.5,1.5.3.1 ko:K00302,ko:K10814 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 - R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 - - - Fer2_4 k59_55282_1 404589.Anae109_1387 1.3e-09 58.2 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2YTWD@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0899 F420_oxidored,P5CR_dimer k59_55282_2 330214.NIDE0771 3.34e-46 150.0 COG0762@1|root,COG0762@2|Bacteria,3J0U5@40117|Nitrospirae 40117|Nitrospirae S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_55282_3 330214.NIDE0772 2.2e-11 61.6 COG3599@1|root,COG3599@2|Bacteria,3J19M@40117|Nitrospirae 40117|Nitrospirae D DivIVA protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA k59_1509_1 330214.NIDE3045 3.53e-73 229.0 COG1210@1|root,COG1210@2|Bacteria,3J0B2@40117|Nitrospirae 40117|Nitrospirae M Nucleotidyl transferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_4736_1 27923.ML17726a-PA 1.13e-59 210.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BBJ8@33208|Metazoa 33154|Opisthokonta - - - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_18768_1 330214.NIDE4148 8.02e-23 96.7 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_18768_2 330214.NIDE4147 2.51e-08 57.0 COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae 40117|Nitrospirae C Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_41295_2 436308.Nmar_1736 2.43e-88 265.0 COG0778@1|root,arCOG00288@2157|Archaea,41S7D@651137|Thaumarchaeota 651137|Thaumarchaeota C Cob(II)yrinic acid a,c-diamide reductase - - 1.13.11.79 ko:K04719 ko00740,ko01100,map00740,map01100 - R09083 RC00435,RC02413 ko00000,ko00001,ko01000 - - - Nitroreductase k59_34753_1 794903.OPIT5_01155 3.62e-14 71.6 COG2308@1|root,COG2308@2|Bacteria,46TR2@74201|Verrucomicrobia,3K7Q4@414999|Opitutae 414999|Opitutae S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_34753_2 1101195.Meth11DRAFT_0069 9.83e-23 97.4 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KKR6@206350|Nitrosomonadales 206350|Nitrosomonadales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_13872_1 876044.IMCC3088_161 7.87e-36 138.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1J5BK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the DNA photolyase family phrB GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_15611_1 7029.ACYPI063714-PA 3.29e-15 80.1 2CXGH@1|root,2RX9T@2759|Eukaryota,39YTV@33154|Opisthokonta,3BMVG@33208|Metazoa,3DDBX@33213|Bilateria,42250@6656|Arthropoda,3SITN@50557|Insecta,3EDB0@33342|Paraneoptera 33208|Metazoa - - - - - - - - - - - - - - - k59_34759_2 1457393.AZ09_09665 1.78e-25 99.4 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,2JS4I@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_39492_1 7668.SPU_022296-tr 7.89e-85 280.0 COG5059@1|root,KOG1075@1|root,KOG0242@2759|Eukaryota,KOG1075@2759|Eukaryota,38GPV@33154|Opisthokonta,3BF94@33208|Metazoa,3CWIA@33213|Bilateria 33208|Metazoa Z microtubule motor activity KIF22 GO:0000070,GO:0000278,GO:0000280,GO:0000775,GO:0000776,GO:0000785,GO:0000819,GO:0000902,GO:0000904,GO:0001654,GO:0001756,GO:0001966,GO:0002376,GO:0002478,GO:0002495,GO:0002504,GO:0003002,GO:0003674,GO:0003676,GO:0003677,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0005871,GO:0005875,GO:0006810,GO:0006890,GO:0006928,GO:0006996,GO:0007017,GO:0007018,GO:0007049,GO:0007059,GO:0007062,GO:0007080,GO:0007275,GO:0007389,GO:0007399,GO:0007409,GO:0007417,GO:0007420,GO:0007423,GO:0008150,GO:0009605,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009952,GO:0009987,GO:0015630,GO:0016043,GO:0016192,GO:0016462,GO:0016604,GO:0016607,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019882,GO:0019884,GO:0019886,GO:0021952,GO:0021953,GO:0021954,GO:0021955,GO:0022008,GO:0022402,GO:0030030,GO:0030154,GO:0030182,GO:0031175,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0032991,GO:0035282,GO:0040011,GO:0042330,GO:0043009,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0048002,GO:0048193,GO:0048285,GO:0048468,GO:0048513,GO:0048592,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050000,GO:0050896,GO:0051179,GO:0051234,GO:0051276,GO:0051303,GO:0051310,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0060322,GO:0060429,GO:0061053,GO:0061564,GO:0070013,GO:0071840,GO:0072686,GO:0090596,GO:0097159,GO:0098687,GO:0098813,GO:0120036,GO:0120039,GO:0140014,GO:1901363,GO:1903047 - ko:K02988,ko:K10403 ko03010,ko04914,map03010,map04914 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko04812 - - - HHH_3,Kinesin k59_6743_1 1255043.TVNIR_3613 7.03e-55 179.0 2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_29751_1 244581.IM40_02690 4.05e-135 391.0 COG3039@1|root,COG3039@2|Bacteria,1Q79J@1224|Proteobacteria,2VDE7@28211|Alphaproteobacteria,47G3F@766|Rickettsiales 766|Rickettsiales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_45865_1 156889.Mmc1_0842 1.43e-45 149.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_4054_1 1122244.AUGF01000070_gene944 1.07e-06 45.4 2DR8E@1|root,33ANS@2|Bacteria,1NI69@1224|Proteobacteria,1SH0M@1236|Gammaproteobacteria,3NQGT@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_32146_1 1298867.AUES01000051_gene4511 1.92e-21 99.8 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_54575_1 335283.Neut_1608 3.48e-101 317.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,371SW@32003|Nitrosomonadales 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_52884_1 7029.ACYPI22631-PA 1.43e-50 184.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera 33208|Metazoa O K02A2.6-like - - - - - - - - - - - - Baculo_F,RVT_1,rve k59_49582_1 351348.Maqu_3437 1.05e-34 124.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,46422@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_49582_2 1245471.PCA10_24300 1.69e-22 96.7 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1YHBH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_28369_1 716544.wcw_1902 1.71e-119 354.0 COG3328@1|root,COG3328@2|Bacteria,2JGVA@204428|Chlamydiae 204428|Chlamydiae L Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_44090_1 113355.CM001775_gene3188 2.51e-29 105.0 2DNQR@1|root,32YKU@2|Bacteria,1G9K3@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_44090_2 1123230.ARQJ01000001_gene1096 2.65e-15 71.2 arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,4HFPA@91061|Bacilli,4GZG2@90964|Staphylococcaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_11133_2 330214.NIDE0405 1.22e-34 125.0 COG2901@1|root,COG2901@2|Bacteria 2|Bacteria K sequence-specific DNA binding fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557,ko:K07712 ko02020,ko05111,map02020,map05111 M00497 - - ko00000,ko00001,ko00002,ko02022,ko03000,ko03036,ko03400 - - - HTH_8 k59_14745_1 2340.JV46_28950 1.02e-50 186.0 2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria 1224|Proteobacteria S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_40675_1 1121098.HMPREF1534_03844 9.36e-35 147.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,2FM8X@200643|Bacteroidia,4AKN4@815|Bacteroidaceae 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_38859_3 1498228.A0A068CC89_9CAUD 2.96e-05 54.7 4QAMU@10239|Viruses,4QPEV@28883|Caudovirales,4QI0J@10662|Myoviridae 10662|Myoviridae S Baseplate J-like protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_38859_4 592029.DDD_1128 3.83e-29 113.0 COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,4NPFE@976|Bacteroidetes,1I26J@117743|Flavobacteriia 976|Bacteroidetes M CHAP domain - - - - - - - - - - - - CHAP k59_38859_10 864073.HFRIS_008881 3.25e-13 71.6 COG4696@1|root,COG4696@2|Bacteria,1NMJC@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria - - - - - - - - - - - - PRA-PH k59_38859_14 189753.AXAS01000006_gene2235 4.92e-85 276.0 COG0553@1|root,COG0553@2|Bacteria,1NII1@1224|Proteobacteria 1224|Proteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_16332_1 1288494.EBAPG3_1970 6.73e-101 310.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,3722A@32003|Nitrosomonadales 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_34010_1 666685.R2APBS1_0201 7.63e-37 132.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1X449@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_34010_2 1479235.KK366039_gene2437 2.08e-26 106.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1XHT8@135619|Oceanospirillales 135619|Oceanospirillales S NAD FAD-binding protein - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase k59_45898_1 482537.XP_008592617.1 6.01e-12 76.3 COG2801@1|root,KOG0017@2759|Eukaryota,38GIZ@33154|Opisthokonta,3BMWT@33208|Metazoa,3CTK8@33213|Bilateria,48A4V@7711|Chordata,48V4Y@7742|Vertebrata,3J4IX@40674|Mammalia,35RJH@314146|Euarchontoglires 33208|Metazoa O genomic stop codons - - - - - - - - - - - - Gag_MA,Gag_p30,RNase_H,RVP,RVT_1,rve,zf-CCHC,zf-H2C2 k59_16341_1 330214.NIDE3244 1.23e-81 264.0 COG4191@1|root,COG5278@1|root,COG4191@2|Bacteria,COG5278@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity fleS - 2.7.13.3 ko:K02668,ko:K07710,ko:K07711,ko:K10942 ko02020,ko02024,ko05111,map02020,map02024,map05111 M00500,M00501,M00502,M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CHASE3,GAF,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_44111_1 203122.Sde_2960 2.6e-38 145.0 COG0457@1|root,COG4105@1|root,COG0457@2|Bacteria,COG4105@2|Bacteria,1QX0H@1224|Proteobacteria,1T32E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_14767_2 330214.NIDE0868 1.11e-61 200.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - DUF3187 k59_34012_1 1122132.AQYH01000015_gene2282 4.78e-07 60.1 2DSRK@1|root,33H6U@2|Bacteria,1P21N@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_11165_1 1499680.CCFE01000031_gene3776 3.43e-54 189.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli,1ZB0Z@1386|Bacillus 91061|Bacilli KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_51308_1 6500.XP_005091913.1 2.12e-33 130.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39TZY@33154|Opisthokonta,3BI15@33208|Metazoa,3CYKV@33213|Bilateria 33208|Metazoa J protein phosphatase regulator activity - - 2.3.1.15,2.4.2.29 ko:K13506,ko:K15407 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R03789,R09380,R10209 RC00004,RC00039,RC00041,RC00063 ko00000,ko00001,ko00002,ko01000,ko01004,ko03016 - - - Exo_endo_phos_2,RVT_1 k59_11167_1 330214.NIDE0482 3.82e-56 181.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion pilA - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - DUF2628,N_methyl,Pilin k59_28408_1 31033.ENSTRUP00000006646 6.54e-43 154.0 2CM8M@1|root,2QPMI@2759|Eukaryota,38BUI@33154|Opisthokonta,3B9D2@33208|Metazoa,3CS85@33213|Bilateria,488CP@7711|Chordata,491MR@7742|Vertebrata,49WEK@7898|Actinopterygii 33208|Metazoa S ADP-ribosylarginine hydrolase adprh - 3.2.2.19 ko:K01245 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_52938_1 1121405.dsmv_0890 3.44e-16 85.9 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein) - - - - - - - - - - - - rve k59_42411_1 485915.Dret_1500 2.84e-49 169.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,2MGH2@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_30287_1 7029.ACYPI50565-PA 9.69e-32 132.0 28IIP@1|root,2QQVP@2759|Eukaryota,39TA7@33154|Opisthokonta,3CNWS@33208|Metazoa,3D3DK@33213|Bilateria 33208|Metazoa S Domain of unknown function (DUF4371) - - - - - - - - - - - - DUF4371,Dimer_Tnp_hAT k59_28420_1 1163617.SCD_n03012 2.96e-51 171.0 COG3087@1|root,COG3087@2|Bacteria,1RIU5@1224|Proteobacteria,2VTKT@28216|Betaproteobacteria 28216|Betaproteobacteria D PFAM Sporulation domain protein - - - - - - - - - - - - SPOR k59_52955_1 6238.CBG05275 1.09e-43 168.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,40IET@6231|Nematoda,1M1Q3@119089|Chromadorea,40UDH@6236|Rhabditida 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_47844_1 1158292.JPOE01000005_gene471 7.9e-112 333.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1KJB5@119065|unclassified Burkholderiales 28216|Betaproteobacteria F May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_49638_4 10370.OBP_HHV6U 3.18e-14 85.9 4QCQ4@10239|Viruses,4QVCT@35237|dsDNA viruses no RNA stage 10239|Viruses L Origin of replication binding protein - GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0004386,GO:0005488,GO:0005575,GO:0008150,GO:0016032,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018995,GO:0019058,GO:0019079,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0039686,GO:0039693,GO:0042025,GO:0043565,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044419,GO:0051704,GO:0097159,GO:1901363,GO:1990837 - - - - - - - - - - - k59_49643_1 330214.NIDE2641 3.73e-29 104.0 COG1278@1|root,COG1278@2|Bacteria,3J0QZ@40117|Nitrospirae 40117|Nitrospirae K 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_51341_1 443152.MDG893_18979 1.24e-55 183.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RQ5E@1236|Gammaproteobacteria,466CU@72275|Alteromonadaceae 1236|Gammaproteobacteria NT COG1352 Methylase of chemotaxis methyl-accepting proteins pilK - 2.1.1.80 ko:K00575,ko:K02661 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035,ko02044 - - - CheR,CheR_N k59_51341_2 1298593.TOL_0274 3.51e-08 53.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XIUV@135619|Oceanospirillales 135619|Oceanospirillales NT chemotaxis protein - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_49644_1 317655.Sala_2518 9.25e-42 153.0 COG1363@1|root,COG1363@2|Bacteria,1MYM4@1224|Proteobacteria,2UR0H@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - Peptidase_M28 k59_19726_1 13735.ENSPSIP00000000799 2.87e-48 172.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_21571_1 1122185.N792_09625 1.77e-08 54.3 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,1S35N@1236|Gammaproteobacteria,1X60X@135614|Xanthomonadales 135614|Xanthomonadales M Sugar ABC transporter substrate-binding protein - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_21571_2 626887.J057_23010 6.92e-31 127.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria,465VX@72275|Alteromonadaceae 1236|Gammaproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - GNVR,Wzz k59_18125_1 247490.KSU1_C1305 4.06e-54 187.0 COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes 203682|Planctomycetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_16416_1 330214.NIDE0354 3.66e-05 44.7 COG0837@1|root,COG0837@2|Bacteria,3J13D@40117|Nitrospirae 40117|Nitrospirae F Glucokinase glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_16416_2 9361.ENSDNOP00000018247 4.28e-32 122.0 COG0363@1|root,KOG3147@2759|Eukaryota,39U1J@33154|Opisthokonta,3BEMD@33208|Metazoa,3CW6A@33213|Bilateria,485RG@7711|Chordata,490GE@7742|Vertebrata,3J6ZY@40674|Mammalia 33208|Metazoa G 6-phosphogluconolactonase activity PGLS GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0030246,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048029,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_35639_2 1555202.A0A097EXC9_9CAUD 4.12e-23 95.9 4QB0E@10239|Viruses,4QQU3@28883|Caudovirales,4QI46@10662|Myoviridae 10662|Myoviridae S Pyrimidine dimer DNA glycosylase - GO:0000704,GO:0003674,GO:0003824,GO:0003906,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0140097 - - - - - - - - - - - k59_13430_1 76869.PputGB1_1151 9.43e-57 187.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1YWVH@136845|Pseudomonas putida group 1236|Gammaproteobacteria I Belongs to the CDS family cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_1596,iSDY_1059.SDY_0191 CTP_transf_1 k59_941_1 7668.SPU_024462-tr 7.35e-26 116.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39NE5@33154|Opisthokonta,3CPYS@33208|Metazoa,3E63Y@33213|Bilateria 2759|Eukaryota S Endonuclease-reverse transcriptase - - - ko:K11320 - - - - ko00000,ko01000,ko03036 - - - DUF4283,HSA,Helicase_C,SNF2_N,zf-CCHC_4 k59_7673_1 566466.NOR53_428 1.45e-96 291.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1J5DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_9427_1 1232683.ADIMK_2729 5.75e-23 97.4 28K8N@1|root,2Z9WC@2|Bacteria,1R5V8@1224|Proteobacteria,1S3I5@1236|Gammaproteobacteria,466GB@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3549) - - - - - - - - - - - - DUF3549 k59_9427_2 243277.VC_1238 5.42e-05 45.8 COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria,1Y2P5@135623|Vibrionales 135623|Vibrionales H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_23708_1 330214.NIDE4140 6.87e-42 139.0 COG1145@1|root,COG1145@2|Bacteria,3J1BF@40117|Nitrospirae 40117|Nitrospirae C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_23708_2 330214.NIDE4139 5.03e-39 135.0 COG1430@1|root,COG1430@2|Bacteria 2|Bacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_49767_1 6087.XP_002163921.2 2.72e-17 84.7 KOG4740@1|root,KOG4740@2759|Eukaryota,3A4S6@33154|Opisthokonta 33154|Opisthokonta S proton channel activity - - - - - - - - - - - - - k59_3024_1 7668.SPU_000868-tr 3.73e-18 89.7 KOG1075@1|root,KOG1075@2759|Eukaryota,39NE5@33154|Opisthokonta,3CPYS@33208|Metazoa,3E63Y@33213|Bilateria 2759|Eukaryota S Endonuclease-reverse transcriptase - - - - - - - - - - - - RVT_1 k59_9432_1 6087.XP_004213368.1 5e-24 111.0 2D4A4@1|root,2SUEX@2759|Eukaryota,3APJ7@33154|Opisthokonta,3C2SU@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - Ank_2 k59_11369_1 1382358.JHVN01000001_gene1123 3.56e-61 202.0 COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,4H9KI@91061|Bacilli,21VEA@150247|Anoxybacillus 91061|Bacilli M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_49786_1 163908.KB235896_gene4281 1.25e-81 251.0 COG0668@1|root,COG0668@2|Bacteria,1G06A@1117|Cyanobacteria 1117|Cyanobacteria M COG0668 Small-conductance mechanosensitive channel - - - - - - - - - - - - MS_channel k59_13170_1 497321.C664_17987 2.74e-31 121.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,2KUYN@206389|Rhodocyclales 206389|Rhodocyclales M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_13170_2 1485544.JQKP01000012_gene2155 6.59e-11 60.8 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,44VSQ@713636|Nitrosomonadales 28216|Betaproteobacteria K Belongs to the UPF0301 (AlgH) family algH - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_3046_2 6412.HelroP195122 1.53e-26 110.0 KOG4012@1|root,KOG4012@2759|Eukaryota,3A3HU@33154|Opisthokonta 33154|Opisthokonta B to Saccharomyces cerevisiae HHO1 (YPL127C) - GO:0000018,GO:0000228,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006323,GO:0006355,GO:0006996,GO:0008150,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0010639,GO:0016043,GO:0019219,GO:0019222,GO:0030261,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031935,GO:0031936,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0033043,GO:0033044,GO:0040029,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0045815,GO:0045893,GO:0045910,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051254,GO:0051276,GO:0060255,GO:0060968,GO:0060969,GO:0065007,GO:0070013,GO:0071103,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1902275,GO:1902680,GO:1903506,GO:1903508,GO:1905268,GO:2000112,GO:2001141,GO:2001251 - ko:K11275 - - - - ko00000,ko03036 - - - Linker_histone k59_3046_3 159749.K0S141 7.34e-31 118.0 2DZNS@1|root,2S75Z@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_3046_4 121225.PHUM003530-PA 7.78e-59 185.0 KOG1744@1|root,KOG1744@2759|Eukaryota,3A1HW@33154|Opisthokonta,3BQEI@33208|Metazoa,3D7NQ@33213|Bilateria,41ZBP@6656|Arthropoda,3SMBY@50557|Insecta,3ECX3@33342|Paraneoptera 33208|Metazoa B Histone H2B.3 - GO:0000228,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0031497,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0034622,GO:0034728,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0051276,GO:0065003,GO:0065004,GO:0070013,GO:0071103,GO:0071824,GO:0071840,GO:0097159,GO:1901363 - ko:K11252,ko:K11275 ko05034,ko05203,ko05322,map05034,map05203,map05322 - - - ko00000,ko00001,ko03036,ko04147 - - - Histone k59_54832_1 2340.JV46_28950 7.05e-51 184.0 2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria 1224|Proteobacteria S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_19882_1 1454004.AW11_04059 1.07e-101 306.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria 28216|Betaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_16584_1 521719.ATXQ01000012_gene1640 2.12e-93 283.0 COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,1YEGK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_46128_1 8083.ENSXMAP00000012258 1.23e-27 114.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F2S@33154|Opisthokonta,3BI3C@33208|Metazoa 33208|Metazoa L Gypsy retrotransposon integrase-like protein GIN1 - - - - - - - - - - - SCAN,THAP,rve,zf-CCHC,zf-H2C2 k59_49821_1 1191523.MROS_0441 3.29e-62 203.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA k59_49821_2 631362.Thi970DRAFT_04350 5.28e-08 56.6 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1S4J0@1236|Gammaproteobacteria,1WY5K@135613|Chromatiales 135613|Chromatiales S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,PEGA k59_27139_1 1298593.TOL_2690 4.7e-100 309.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XIFS@135619|Oceanospirillales 135619|Oceanospirillales CI Oxaloacetate decarboxylase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_51527_1 391615.ABSJ01000055_gene1323 1.8e-28 107.0 COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,1S65C@1236|Gammaproteobacteria,1J6T7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG2166 SufE protein probably involved in Fe-S center assembly sufE - - ko:K02426 - - - - ko00000 - - - SufE k59_51527_2 1122212.AULO01000012_gene1091 2.17e-76 230.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1XJ9H@135619|Oceanospirillales 135619|Oceanospirillales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_6207_2 999423.HMPREF9161_00230 4.08e-11 64.7 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4H2P5@909932|Negativicutes 909932|Negativicutes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_28597_1 10224.XP_006813780.1 7.52e-72 232.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y9N@33154|Opisthokonta,3BKRZ@33208|Metazoa,3CWQ0@33213|Bilateria 33208|Metazoa S Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_37324_1 998088.B565_1741 1.18e-28 113.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1Y3RM@135624|Aeromonadales 135624|Aeromonadales IQ Belongs to the beta-ketoacyl-ACP synthases family fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_9482_1 420662.Mpe_A2180 4.32e-32 116.0 2EKZU@1|root,33EPA@2|Bacteria,1NNWE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_9482_2 76114.ebA3640 2.21e-16 77.4 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,2KVJQ@206389|Rhodocyclales 206389|Rhodocyclales C COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_48050_1 7918.ENSLOCP00000012840 1.34e-101 311.0 2CM8M@1|root,2QPMI@2759|Eukaryota,38BUI@33154|Opisthokonta,3B9D2@33208|Metazoa,3CS85@33213|Bilateria,488CP@7711|Chordata,491MR@7742|Vertebrata,49WEK@7898|Actinopterygii 33208|Metazoa S ADP-ribosylarginine hydrolase ADPRH GO:0000287,GO:0003674,GO:0003824,GO:0003875,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019538,GO:0030955,GO:0031420,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0071704,GO:1901564 3.2.2.19 ko:K01245 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_34308_1 196490.AUEZ01000126_gene2369 1.35e-15 73.6 COG3293@1|root,COG3293@2|Bacteria,1N13W@1224|Proteobacteria,2TX4D@28211|Alphaproteobacteria,3K606@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_34308_2 1009370.ALO_21876 1e-27 104.0 COG3293@1|root,COG3293@2|Bacteria,1UQVM@1239|Firmicutes,4H8RS@909932|Negativicutes 909932|Negativicutes L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DUF4096 k59_42620_1 583345.Mmol_2181 5.84e-57 191.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KKZV@206350|Nitrosomonadales 206350|Nitrosomonadales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_44342_1 6326.BUX.s00116.670 7.82e-23 102.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,40FP8@6231|Nematoda,1KXGN@119089|Chromadorea 33208|Metazoa L K02A2.6-like - - - - - - - - - - - - AAA_12,Asp_protease_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve,zf-CCHC k59_32523_1 1479237.JMLY01000001_gene3365 9.89e-84 275.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,46DE0@72275|Alteromonadaceae 1236|Gammaproteobacteria EI Allophanate hydrolase subunit 1 uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_19918_2 330214.NIDE1920 3.43e-23 97.8 COG0621@1|root,COG0621@2|Bacteria,3J112@40117|Nitrospirae 40117|Nitrospirae J Uncharacterized protein family UPF0004 - - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_11440_1 7091.BGIBMGA000159-TA 7.09e-39 142.0 2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa,3E5DG@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_40935_1 288000.BBta_0993 2.06e-20 95.9 COG3307@1|root,COG3307@2|Bacteria,1MV4S@1224|Proteobacteria,2TV8W@28211|Alphaproteobacteria,3K353@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M -O-antigen - - - - - - - - - - - - - k59_4359_1 1121940.AUDZ01000005_gene1572 8.42e-73 242.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XIHW@135619|Oceanospirillales 135619|Oceanospirillales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom k59_32538_1 1131266.ARWQ01000001_gene1176 7.94e-72 224.0 arCOG08038@1|root,arCOG08038@2157|Archaea,41SZN@651137|Thaumarchaeota 651137|Thaumarchaeota S protein secretion by the type IV secretion system - - - - - - - - - - - - - k59_32538_2 436308.Nmar_0335 7.45e-06 45.1 arCOG06055@1|root,arCOG06055@2157|Archaea,41SQ3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_54888_1 1122212.AULO01000006_gene1656 1.8e-64 207.0 COG3751@1|root,COG3751@2|Bacteria,1RD3H@1224|Proteobacteria,1S40I@1236|Gammaproteobacteria,1XK5C@135619|Oceanospirillales 135619|Oceanospirillales O 2OG-Fe(II) oxygenase - - - ko:K07394 - - - - ko00000 - - - 2OG-FeII_Oxy_3 k59_53240_1 1122197.ATWI01000009_gene1682 3.34e-100 317.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,465AY@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_18340_1 265072.Mfla_2533 2.93e-63 218.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,2KM30@206350|Nitrosomonadales 206350|Nitrosomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18303 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.17 - - ACR_tran k59_18340_2 1485543.JMME01000004_gene154 3.21e-11 65.9 COG0845@1|root,COG0845@2|Bacteria,1U1UF@1239|Firmicutes,4H27Y@909932|Negativicutes 909932|Negativicutes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18302 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_37355_1 7029.ACYPI005515-PA 4.49e-10 66.2 KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda 33208|Metazoa S Endonuclease-reverse transcriptase - - - ko:K10443 - - - - ko00000,ko04121 - - - Exo_endo_phos_2,RNase_H,RVT_1 k59_40952_1 1229909.NSED_01675 5.34e-102 325.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_35878_1 1229909.NSED_08265 1.12e-132 377.0 arCOG08699@1|root,arCOG08699@2157|Archaea,41S8N@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Ammonia monooxygenase methane monooxygenase, subunit C - - - ko:K10946 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002 - - - AmoC k59_42649_1 754477.Q7C_490 5.77e-39 146.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_11471_1 7668.SPU_009162-tr 2.61e-35 136.0 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - RVT_1 k59_37359_2 472759.Nhal_3839 9.35e-46 157.0 2F58Z@1|root,33XV7@2|Bacteria,1QRK0@1224|Proteobacteria,1SNW1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_49883_1 1248232.BANQ01000072_gene1721 3.21e-36 129.0 COG1143@1|root,COG1145@1|root,COG1143@2|Bacteria,COG1145@2|Bacteria,1N09Y@1224|Proteobacteria,1S4EB@1236|Gammaproteobacteria,1XWXY@135623|Vibrionales 135623|Vibrionales C COG1145 Ferredoxin napF - - ko:K02572 - - - - ko00000 - - - Fer4,Fer4_4,Fer4_7,Fer4_9 k59_54694_1 1229909.NSED_01325 7.78e-110 334.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_47879_1 83406.HDN1F_16920 4.03e-20 87.4 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,1S97W@1236|Gammaproteobacteria,1J70Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0226 ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - PBP_like_2 k59_34094_1 7091.BGIBMGA000159-TA 2.64e-49 170.0 2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa,3E5DG@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_52998_1 1229909.NSED_01320 7.14e-101 306.0 COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_37192_1 1121267.JHZL01000039_gene458 2.41e-43 142.0 2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria,42WB2@68525|delta/epsilon subdivisions,2YRYT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - k59_9344_2 7425.NV19139-PA 6.33e-54 199.0 COG2801@1|root,KOG0017@2759|Eukaryota,39NC5@33154|Opisthokonta,3CPWT@33208|Metazoa,3E61X@33213|Bilateria,42B4I@6656|Arthropoda,3T0IH@50557|Insecta,46N17@7399|Hymenoptera 33208|Metazoa L transposition, RNA-mediated - - - - - - - - - - - - - k59_9344_5 7070.TC014830-PA 4.72e-32 130.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BPF6@33208|Metazoa,3E413@33213|Bilateria,42A7E@6656|Arthropoda 33208|Metazoa L Integrase core domain - - - - - - - - - - - - Chromo,rve k59_25118_1 10224.XP_006811646.1 8.53e-59 204.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3A4K9@33154|Opisthokonta,3BSC4@33208|Metazoa,3D93E@33213|Bilateria 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_7580_1 6412.HelroP160923 3.9e-71 243.0 2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa,3E5DG@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_32307_1 416269.APL_1728 5.96e-96 311.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1Y7A2@135625|Pasteurellales 135625|Pasteurellales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_45989_1 1380350.JIAP01000018_gene156 6.67e-42 156.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,43HJU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_53023_1 994479.GL877878_gene1463 3.39e-56 191.0 COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4DX52@85010|Pseudonocardiales 201174|Actinobacteria G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_46000_1 2340.JV46_28950 2.04e-88 290.0 2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria 1224|Proteobacteria S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_44221_1 911239.CF149_07039 1.36e-45 156.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorC corC GO:0001897,GO:0001906,GO:0001907,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0009987,GO:0016020,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071944 - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_44221_2 1236959.BAMT01000004_gene825 0.000336 42.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2VSHV@28216|Betaproteobacteria,2KMVG@206350|Nitrosomonadales 206350|Nitrosomonadales J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_46005_1 330214.NIDE3256 5.16e-183 515.0 COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae 2|Bacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ddhB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Fer4_11 k59_27002_1 8469.XP_007052743.1 1.86e-68 238.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,48NVP@7711|Chordata,49IM1@7742|Vertebrata,4CIIU@8459|Testudines 33208|Metazoa L K02A2.6-like - - - - - - - - - - - - Asp_protease_2,PNMA,RVT_1,rve k59_18171_2 7668.SPU_004303-tr 2.24e-50 189.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D40D@33213|Bilateria 33208|Metazoa L transposition, RNA-mediated - - - - - - - - - - - - Chromo,rve k59_18171_4 7070.TC014830-PA 1.78e-08 65.5 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BPF6@33208|Metazoa,3E413@33213|Bilateria,42A7E@6656|Arthropoda 33208|Metazoa L Integrase core domain - - - - - - - - - - - - Chromo,rve k59_885_1 930169.B5T_00062 2.52e-28 112.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1S0CW@1236|Gammaproteobacteria,1XJD8@135619|Oceanospirillales 135619|Oceanospirillales NT COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain - - - ko:K06597 ko02020,map02020 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheB_methylest k59_885_2 1452718.JBOY01000008_gene3463 1.89e-19 84.3 COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis signal transduction protein chpC - - ko:K06598 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035 - - - CheW k59_51419_3 7425.NV21081-PA 5.39e-18 82.4 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BPF6@33208|Metazoa,3E413@33213|Bilateria 33208|Metazoa L Integrase core domain - - - - - - - - - - - - Chromo,rve k59_47944_2 1399147.P618_200441 1.01e-18 84.7 COG3926@1|root,COG3926@2|Bacteria 2|Bacteria S Glycosyl hydrolase 108 - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Glyco_hydro_108,PG_binding_3 k59_46046_1 1131266.ARWQ01000005_gene828 1.43e-105 309.0 COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota 651137|Thaumarchaeota S Chlorite dismutase - - - - - - - - - - - - Chlor_dismutase k59_21702_1 118168.MC7420_811 1.14e-32 126.0 COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,1G285@1117|Cyanobacteria,1H7BF@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_21702_2 867903.ThesuDRAFT_01270 2.04e-28 107.0 COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia,3WCNY@538999|Clostridiales incertae sedis 186801|Clostridia S Metal-sensitive transcriptional repressor csoR - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_44263_1 1288826.MSNKSG1_00581 2.17e-43 141.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,467T8@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_44263_2 1395571.TMS3_0106015 1.13e-16 80.9 2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1S61M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - - k59_928_1 1382304.JNIL01000001_gene1912 1.31e-32 129.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,2787M@186823|Alicyclobacillaceae 91061|Bacilli T His Kinase A (phosphoacceptor) domain phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like k59_53100_1 566466.NOR53_528 2.24e-22 99.8 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1JB4I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_14516_1 1144275.COCOR_07552 1.58e-26 113.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_22557_1 330214.NIDE4080 2.1e-43 148.0 COG0463@1|root,COG0463@2|Bacteria,3J13C@40117|Nitrospirae 40117|Nitrospirae M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_22557_2 944480.ATUV01000002_gene236 5.93e-34 120.0 COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria,2M7H7@213113|Desulfurellales 28221|Deltaproteobacteria M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_41446_1 748247.AZKH_0286 3.64e-52 171.0 COG3245@1|root,COG3245@2|Bacteria 2|Bacteria C photosynthesis - - - - - - - - - - - - Cytochrome_C7,Cytochrome_CBB3 k59_6921_1 330214.NIDE0840 2.15e-08 54.3 COG0045@1|root,COG0045@2|Bacteria,3J0ZB@40117|Nitrospirae 40117|Nitrospirae F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_6921_2 330214.NIDE0839 6.49e-104 315.0 COG0029@1|root,COG0029@2|Bacteria,3J0WB@40117|Nitrospirae 40117|Nitrospirae C FAD binding domain - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_25883_1 491952.Mar181_1266 9.2e-76 242.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1XIK9@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_25883_2 28258.KP05_05725 1.7e-23 92.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,1S9TS@1236|Gammaproteobacteria,1XK69@135619|Oceanospirillales 135619|Oceanospirillales C Membrane-anchoring subunit of succinate dehydrogenase (SDH) sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_44807_1 1123393.KB891326_gene133 9.22e-95 285.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KRZI@119069|Hydrogenophilales 119069|Hydrogenophilales C NiFe/NiFeSe hydrogenase small subunit C-terminal - - - - - - - - - - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_10043_1 365528.KB891181_gene4717 7.48e-85 261.0 COG2159@1|root,COG2159@2|Bacteria,2GKAB@201174|Actinobacteria 201174|Actinobacteria S PFAM Amidohydrolase 2 - - - - - - - - - - - - Amidohydro_2 k59_12063_1 7029.ACYPI085336-PA 1.02e-38 148.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D40D@33213|Bilateria,4222J@6656|Arthropoda,3SQHH@50557|Insecta 33208|Metazoa L transposition, RNA-mediated - - - - - - - - - - - - rve k59_39651_1 880072.Desac_1885 8.55e-69 221.0 COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,42Q26@68525|delta/epsilon subdivisions,2WPER@28221|Deltaproteobacteria,2MSF2@213462|Syntrophobacterales 28221|Deltaproteobacteria D TIGRFAM N-acetyl sugar amidotransferase - - - - - - - - - - - - - k59_37911_1 7668.SPU_028185-tr 2.13e-32 130.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria 33208|Metazoa S Ribonuclease H protein - - - ko:K10443 - - - - ko00000,ko04121 - - - Exo_endo_phos_2,RNase_H,RVT_1 k59_4954_1 1298593.TOL_3479 9.08e-77 242.0 COG1226@1|root,COG1226@2|Bacteria,1R7GA@1224|Proteobacteria,1RZ46@1236|Gammaproteobacteria,1XIR2@135619|Oceanospirillales 135619|Oceanospirillales P PFAM Ion transport 2 - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_6958_1 5341.XP_007333955.1 1.51e-20 99.0 2D1RE@1|root,2SIZV@2759|Eukaryota,3AFJR@33154|Opisthokonta,3PCBT@4751|Fungi,3V3W0@5204|Basidiomycota,226TY@155619|Agaricomycetes,3W7GU@5338|Agaricales 4751|Fungi - - - - - - - - - - - - - - - k59_48699_2 27923.ML215416a-PA 8.82e-13 69.7 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_10057_3 1541065.JRFE01000037_gene6020 2.03e-11 63.2 COG1694@1|root,COG1694@2|Bacteria,1GA07@1117|Cyanobacteria 1117|Cyanobacteria S Pyrophosphatase - - - - - - - - - - - - MazG k59_4975_2 1316936.K678_00200 1.67e-12 67.8 2DPYK@1|root,333Z3@2|Bacteria,1NEX0@1224|Proteobacteria,2UGR4@28211|Alphaproteobacteria,2JUIP@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_31251_1 1046724.KB889901_gene3233 1.26e-73 243.0 COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,1S3KJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1 k59_52212_1 400682.PAC_15702057 1.57e-48 177.0 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - RVT_1,zf-RVT k59_19046_1 289376.THEYE_A1905 1.22e-56 188.0 COG4249@1|root,COG4249@2|Bacteria,3J0QX@40117|Nitrospirae 40117|Nitrospirae S Evidence 5 No homology to any previously reported sequences - - - ko:K07126 - - - - ko00000 - - - Peptidase_C14 k59_41540_1 436308.Nmar_1367 6.44e-125 367.0 arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_25964_1 8081.XP_008425483.1 1.92e-84 272.0 29YJV@1|root,2RXU5@2759|Eukaryota,3A0FB@33154|Opisthokonta,3BPYT@33208|Metazoa,3D6GB@33213|Bilateria,48G4U@7711|Chordata,49D4K@7742|Vertebrata,4A7F2@7898|Actinopterygii 33208|Metazoa - - - - - - - - - - - - - - - k59_20527_1 378806.STAUR_3100 2.62e-120 360.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_5039_1 909663.KI867150_gene2770 8.95e-22 101.0 COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - UPF0236 k59_10117_1 159087.Daro_3360 3.22e-16 77.8 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KUQG@206389|Rhodocyclales 206389|Rhodocyclales T Serine/threonine phosphatases, family 2C, catalytic domain pppL - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_10117_2 640081.Dsui_1451 6.08e-41 141.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_29152_2 344747.PM8797T_27949 6.52e-45 149.0 COG3436@1|root,COG3436@2|Bacteria 2|Bacteria L PFAM IS66 Orf2 family protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_29152_4 555779.Dthio_PD3704 5.14e-177 517.0 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_37983_1 1298593.TOL_2487 7.04e-37 134.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,1RNG2@1236|Gammaproteobacteria,1XJNC@135619|Oceanospirillales 135619|Oceanospirillales NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) cheZ - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_37983_2 1123228.AUIH01000005_gene748 5.04e-06 45.8 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,1S47I@1236|Gammaproteobacteria,1XJKC@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_10121_1 330214.NIDE1822 8.28e-22 86.3 COG2104@1|root,COG2104@2|Bacteria 2|Bacteria H thiamine diphosphate biosynthetic process thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_37987_1 1211817.CCAT010000070_gene1234 7.7e-14 71.6 COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,36DXS@31979|Clostridiaceae 186801|Clostridia I Alpha beta - - - - - - - - - - - - Hydrolase_4 k59_48780_3 877414.ATWA01000046_gene1845 3.63e-24 100.0 COG1611@1|root,COG1611@2|Bacteria,1V7HV@1239|Firmicutes,24JN5@186801|Clostridia 186801|Clostridia S Belongs to the LOG family - - - - - - - - - - - - - k59_48780_5 1384066.JAGT01000001_gene956 2.15e-30 122.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WH0A@541000|Ruminococcaceae 186801|Clostridia L helicase - - - - - - - - - - - - Helicase_C,SNF2_N k59_20560_1 1266925.JHVX01000009_gene144 2.15e-69 221.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VJFX@28216|Betaproteobacteria,3721V@32003|Nitrosomonadales 28216|Betaproteobacteria C Zinc-binding dehydrogenase qor3 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_19110_1 330214.NIDE1381 9.8e-98 292.0 COG0568@1|root,COG0568@2|Bacteria 2|Bacteria K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_46953_1 1298593.TOL_0279 2.08e-66 210.0 COG1209@1|root,COG1209@2|Bacteria,1RDR2@1224|Proteobacteria,1S4I7@1236|Gammaproteobacteria,1XNXD@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis - - - - - - - - - - - - - k59_39766_1 1205680.CAKO01000010_gene3806 3.15e-11 67.0 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2TSZA@28211|Alphaproteobacteria,2JSG8@204441|Rhodospirillales 204441|Rhodospirillales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_41600_1 55529.EKX44397 1.08e-59 230.0 2CN0N@1|root,2QT5H@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_46967_1 330214.NIDE2543 8.84e-20 87.8 COG0616@1|root,COG0616@2|Bacteria,3J13W@40117|Nitrospirae 40117|Nitrospirae OU Peptidase family S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_46967_2 330214.NIDE2544 2.82e-17 82.0 COG4783@1|root,COG4783@2|Bacteria 2|Bacteria L chaperone-mediated protein folding - - - - - - - - - - - - Peptidase_M48 k59_38029_1 557598.LHK_01542 3.62e-83 258.0 28HXV@1|root,2Z83C@2|Bacteria,1PJBP@1224|Proteobacteria,2VZV5@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_43344_1 7425.NV14023-PA 2.34e-68 220.0 COG2124@1|root,COG5262@1|root,KOG0157@2759|Eukaryota,KOG1756@2759|Eukaryota,3A1K0@33154|Opisthokonta,3BPSK@33208|Metazoa,3D6YF@33213|Bilateria 33208|Metazoa B Protein heterodimerization activity - - - ko:K11251,ko:K15001 ko04217,ko05034,ko05322,map04217,map05034,map05322 - - - ko00000,ko00001,ko00199,ko01000,ko03036,ko04147 - - - Histone,Histone_H2A_C k59_43344_2 10029.XP_007634688.1 8.66e-77 250.0 COG2036@1|root,COG5262@1|root,KOG1745@2759|Eukaryota,KOG1756@2759|Eukaryota,39ZTV@33154|Opisthokonta,3BPDH@33208|Metazoa,3D6BK@33213|Bilateria,48E1W@7711|Chordata,49B7M@7742|Vertebrata,3JGKY@40674|Mammalia,35PSM@314146|Euarchontoglires,4Q54X@9989|Rodentia 33208|Metazoa B Core histone H2A/H2B/H3/H4 HIST3H3 GO:0000228,GO:0000723,GO:0000726,GO:0000785,GO:0000786,GO:0000788,GO:0000790,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006323,GO:0006325,GO:0006333,GO:0006334,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016233,GO:0022607,GO:0031333,GO:0031490,GO:0031491,GO:0031492,GO:0031497,GO:0031974,GO:0031981,GO:0032200,GO:0032459,GO:0032460,GO:0032991,GO:0032993,GO:0033554,GO:0034622,GO:0034641,GO:0034728,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044815,GO:0044877,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051259,GO:0051262,GO:0051276,GO:0051290,GO:0051291,GO:0051716,GO:0060249,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K11253,ko:K11275 ko05034,ko05202,ko05322,map05034,map05202,map05322 - - - ko00000,ko00001,ko03036,ko04147 - - - Histone k59_10182_1 671143.DAMO_2187 6.63e-86 266.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N,Response_reg k59_41648_1 330214.NIDE3714 2.61e-44 153.0 COG0739@1|root,COG0739@2|Bacteria,3J0N3@40117|Nitrospirae 40117|Nitrospirae M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_41649_1 330214.NIDE0902 1.09e-74 228.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c soxD - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_38054_1 1229909.NSED_09115 7.26e-48 166.0 COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota 651137|Thaumarchaeota M extracellular matrix structural constituent - - - - - - - - - - - - - k59_38054_2 1229909.NSED_09120 2.08e-07 50.8 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_26294_1 261292.Nit79A3_1075 8.45e-73 230.0 COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_31562_1 1380355.JNIJ01000006_gene3041 2.46e-88 271.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_15844_1 330214.NIDE0004 5.52e-48 171.0 COG0188@1|root,COG0188@2|Bacteria,3J0EH@40117|Nitrospirae 40117|Nitrospirae L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_47230_2 649747.HMPREF0083_01903 1.78e-46 169.0 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,4IS56@91061|Bacilli,26V5T@186822|Paenibacillaceae 91061|Bacilli C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_17579_1 7955.ENSDARP00000106282 3.12e-33 129.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_22864_2 7668.SPU_017479-tr 6.12e-57 213.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_19300_1 4558.Sb09g021410.1 4.31e-27 114.0 KOG0583@1|root,KOG0583@2759|Eukaryota,37S3B@33090|Viridiplantae,3G8X1@35493|Streptophyta,3KS48@4447|Liliopsida,3IN7K@38820|Poales 35493|Streptophyta T belongs to the protein kinase superfamily SnRK2.4 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0006970,GO:0007154,GO:0007165,GO:0007275,GO:0008150,GO:0008152,GO:0008289,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009651,GO:0009791,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0022622,GO:0023052,GO:0032501,GO:0032502,GO:0035556,GO:0036211,GO:0042742,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048364,GO:0048527,GO:0048528,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070300,GO:0071704,GO:0090696,GO:0098542,GO:0099402,GO:0140096,GO:1901564 2.7.11.1 ko:K14498 ko04016,ko04075,map04016,map04075 - - - ko00000,ko00001,ko01000,ko01001 - - - Pkinase k59_5435_1 1415780.JPOG01000001_gene964 2.11e-131 385.0 COG1960@1|root,COG1960@2|Bacteria,1R5M1@1224|Proteobacteria,1SKHT@1236|Gammaproteobacteria,1X9EP@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_41985_1 1123228.AUIH01000036_gene2822 5.05e-32 122.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XINT@135619|Oceanospirillales 135619|Oceanospirillales O COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_41985_2 498211.CJA_1470 1.87e-44 156.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1FGAB@10|Cellvibrio 1236|Gammaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K01766,ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5,SufE k59_26337_1 7668.SPU_008131-tr 4.03e-52 188.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria 33208|Metazoa E K02A2.6-like - - - - - - - - - - - - RVT_1,SCAN,gag-asp_proteas,rve,zf-CCHC,zf-H2C2 k59_8867_1 7425.NV18646-PA 3.16e-65 230.0 2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SSUA@50557|Insecta,46JQM@7399|Hymenoptera 33208|Metazoa S nucleic acid binding - - - - - - - - - - - - DNA_pol_B_2,Endonuclease_7 k59_50775_1 7668.SPU_021835-tr 1.84e-22 99.4 KOG1075@1|root,KOG1075@2759|Eukaryota 2759|Eukaryota E Ribonuclease H protein - - - - - - - - - - - - Exo_endo_phos_2,RVT_1,RVT_3 k59_8872_1 330214.NIDE3969 7.68e-43 155.0 COG2274@1|root,COG2274@2|Bacteria 2|Bacteria V protein secretion by the type I secretion system - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_5455_1 105559.Nwat_1002 5.22e-43 146.0 COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria,1WY7C@135613|Chromatiales 135613|Chromatiales C ATP synthase subunit C - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k59_49069_1 1236959.BAMT01000003_gene613 1.15e-91 281.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,2KKN0@206350|Nitrosomonadales 206350|Nitrosomonadales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_38505_1 330214.NIDE3255 1.83e-131 403.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_38505_2 330214.NIDE3256 8.57e-19 84.0 COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae 2|Bacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ddhB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Fer4_11 k59_22891_1 292564.Cyagr_0388 3.01e-17 83.2 COG4678@1|root,COG4678@2|Bacteria,1GE65@1117|Cyanobacteria,22SQJ@167375|Cyanobium 1117|Cyanobacteria G Muramidase (Phage lambda lysozyme) - - - - - - - - - - - - - k59_22901_1 795666.MW7_2236 8.24e-67 227.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_7154_1 1121472.AQWN01000001_gene87 0.000518 44.7 2CIAJ@1|root,31W2T@2|Bacteria,1V9NR@1239|Firmicutes,24KRW@186801|Clostridia,262B6@186807|Peptococcaceae 186801|Clostridia S Universal stress protein family - - - - - - - - - - - - Usp k59_47301_1 330214.NIDE3569 1.14e-90 272.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities norQ - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_43750_1 330214.NIDE4102 1.58e-74 231.0 COG1989@1|root,COG1989@2|Bacteria,3J0SK@40117|Nitrospirae 40117|Nitrospirae NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_15910_1 1123487.KB892865_gene1410 3.22e-20 88.6 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,2VI3P@28216|Betaproteobacteria,2KUKX@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase dnaL - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_40292_1 330214.NIDE3071 3.86e-15 73.2 COG0336@1|root,COG0336@2|Bacteria,3J0JN@40117|Nitrospirae 40117|Nitrospirae J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_40292_2 936573.HMPREF1147_0683 1.83e-16 78.6 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,4H56U@909932|Negativicutes 909932|Negativicutes J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_3725_1 330214.NIDE3046 3.37e-81 263.0 COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae 40117|Nitrospirae O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_49135_1 31234.CRE21847 3.36e-34 135.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D40D@33213|Bilateria,40R4D@6231|Nematoda,1M86G@119089|Chromadorea,40WSN@6236|Rhabditida 33208|Metazoa L Chromatin organization modifier domain - - - - - - - - - - - - Chromo,rve k59_17673_1 765912.Thimo_1549 3.11e-74 235.0 COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,1RQFR@1236|Gammaproteobacteria,1WZGI@135613|Chromatiales 135613|Chromatiales P PFAM sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_3729_1 448385.sce6983 4.08e-94 289.0 COG3209@1|root,COG3385@1|root,COG3209@2|Bacteria,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,437YG@68525|delta/epsilon subdivisions,2X38D@28221|Deltaproteobacteria,2YUTS@29|Myxococcales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_14249_1 330214.NIDE3734 2.88e-77 237.0 COG0356@1|root,COG0356@2|Bacteria,3J0RW@40117|Nitrospirae 40117|Nitrospirae C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_14250_1 1229909.NSED_09155 1.27e-55 182.0 COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota 651137|Thaumarchaeota S Pfam:DUF137 - - 6.3.2.36 ko:K09722 ko00410,ko00770,ko01100,map00410,map00770,map01100 - R09379 RC00096,RC00141 ko00000,ko00001,ko01000 - - - PPS_PS k59_3739_1 215358.XP_010743720.1 1.68e-53 191.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_50857_2 1121447.JONL01000007_gene1398 2.02e-06 50.1 2BJPA@1|root,32E0W@2|Bacteria,1QTDF@1224|Proteobacteria,436YG@68525|delta/epsilon subdivisions,2X1NS@28221|Deltaproteobacteria,2MFDS@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_2167_1 1232410.KI421424_gene1723 1.06e-71 229.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43SEG@69541|Desulfuromonadales 28221|Deltaproteobacteria O DnaJ central domain dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_21183_1 1298593.TOL_0918 1.16e-146 427.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XHRM@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the peptidase S1C family mucD GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_10750_2 7668.SPU_027105-tr 2.84e-22 103.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D40D@33213|Bilateria 33208|Metazoa L transposition, RNA-mediated - - - - - - - - - - - - Chromo,rve k59_12520_1 2340.JV46_28950 6.67e-32 128.0 2DY5I@1|root,3488J@2|Bacteria,1P3B4@1224|Proteobacteria 1224|Proteobacteria S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_26476_1 264730.PSPPH_0505 6.64e-79 247.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RNCW@1236|Gammaproteobacteria,1Z62W@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S HI0933-like protein yhiN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07007 - - - - ko00000 - - - HI0933_like k59_2203_1 7668.SPU_016320-tr 1.79e-31 124.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria 33208|Metazoa L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_5561_2 1505225.A0A068CDE9_9CAUD 2.97e-28 110.0 4QAVB@10239|Viruses,4QPIJ@28883|Caudovirales,4QI48@10662|Myoviridae 10662|Myoviridae S defense response to bacterium - - - - - - - - - - - - - k59_5561_3 426117.M446_4057 2.44e-45 161.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,2TUCR@28211|Alphaproteobacteria 28211|Alphaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_15999_1 330214.NIDE2777 2.7e-64 206.0 COG0384@1|root,COG0384@2|Bacteria 2|Bacteria S isomerase activity yddE - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k59_341_1 671143.DAMO_2858 1.5e-47 167.0 COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria 2|Bacteria S Putative modulator of DNA gyrase pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_47406_1 7668.SPU_008324-tr 1.11e-19 97.8 2CMGD@1|root,2QQ9V@2759|Eukaryota,39B3J@33154|Opisthokonta,3BKG5@33208|Metazoa,3CTR5@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - DNA_pol_B_2 k59_5575_1 1229909.NSED_09185 1.55e-90 273.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_21217_2 123899.JPQP01000006_gene733 7.13e-05 48.9 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,3T4DT@506|Alcaligenaceae 28216|Betaproteobacteria S PFAM TPR repeat-containing protein - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_8 k59_19403_1 6412.HelroP164616 2.28e-105 313.0 2B1C7@1|root,2S0A1@2759|Eukaryota,3AEY4@33154|Opisthokonta,3CP8T@33208|Metazoa,3E5DC@33213|Bilateria 33208|Metazoa S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_33627_1 330214.NIDE1059 2.86e-77 241.0 COG0404@1|root,COG0404@2|Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT - 1.5.99.5,2.1.2.10 ko:K00605,ko:K06980,ko:K22086 ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200 M00532 R00609,R01221,R02300,R04125 RC00022,RC00069,RC00183,RC00190,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000,ko03016 - - - GCV_T,GCV_T_C k59_11487_1 28377.ENSACAP00000022749 2.3e-70 220.0 KOG1075@1|root,KOG1075@2759|Eukaryota,3A2AS@33154|Opisthokonta,3BQXW@33208|Metazoa,3D7U3@33213|Bilateria,48HBX@7711|Chordata,49D5V@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_7799_1 1434325.AZQN01000003_gene1985 8.9e-20 90.9 COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,47JJY@768503|Cytophagia 976|Bacteroidetes L Belongs to the 'phage' integrase family xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_7799_2 330214.NIDE0295 3.52e-18 83.2 COG1206@1|root,COG1206@2|Bacteria,3J0WT@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_35895_1 6087.XP_004212156.1 3.73e-37 147.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa 33208|Metazoa G Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_32590_1 13249.RPRC010587-PA 4.44e-18 88.6 KOG1075@1|root,KOG1075@2759|Eukaryota,3A278@33154|Opisthokonta,3BQC7@33208|Metazoa,3D3FI@33213|Bilateria,422CS@6656|Arthropoda,3SUI6@50557|Insecta,3ECF5@33342|Paraneoptera 33208|Metazoa S Endonuclease-reverse transcriptase - - - ko:K10443 - - - - ko00000,ko04121 - - - Exo_endo_phos_2,RNase_H,RVT_1 k59_51605_1 404380.Gbem_0212 2.06e-47 167.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_16662_1 2340.JV46_02190 5.25e-29 118.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1J52P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_32593_1 1173022.Cri9333_0059 1.63e-40 140.0 COG0614@1|root,COG0614@2|Bacteria,1G73G@1117|Cyanobacteria,1HFHX@1150|Oscillatoriales 1117|Cyanobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_42681_1 1298593.TOL_2528 4.71e-57 200.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,1RS2S@1236|Gammaproteobacteria,1XKCN@135619|Oceanospirillales 135619|Oceanospirillales N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_28661_1 244447.XP_008333619.1 8.29e-57 202.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39N4Q@33154|Opisthokonta,3B9WN@33208|Metazoa,3D1S8@33213|Bilateria,48C1W@7711|Chordata,49N8J@7742|Vertebrata,4A94B@7898|Actinopterygii 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_40981_1 215803.DB30_0330 1.04e-09 61.2 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1Q3H7@1224|Proteobacteria,4399Q@68525|delta/epsilon subdivisions,2X4H6@28221|Deltaproteobacteria,2YZ0B@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase,TPR_12 k59_35921_1 28258.KP05_12705 1.07e-15 75.5 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_35921_2 1123400.KB904746_gene1340 3.21e-76 238.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,4609E@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_35922_1 13735.ENSPSIP00000000799 4.19e-98 306.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria,48DPU@7711|Chordata,49A9G@7742|Vertebrata 33208|Metazoa S Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 k59_19992_1 1123487.KB892865_gene1410 3.42e-51 172.0 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,2VI3P@28216|Betaproteobacteria,2KUKX@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase dnaL - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 k59_21907_2 192952.MM_1980 1.67e-08 57.0 COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia 224756|Methanomicrobia C Formylmethanofuran dehydrogenase, subunit B fwdB-1 - 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Molybdopterin k59_3251_1 1317122.ATO12_24140 1.37e-49 175.0 COG2838@1|root,COG2838@2|Bacteria,4NFV1@976|Bacteroidetes,1HXKQ@117743|Flavobacteriia,2YJ1C@290174|Aquimarina 976|Bacteroidetes C Monomeric isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_13330_1 1249627.D779_4175 7.5e-07 56.6 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_51628_1 1279038.KB907345_gene3490 2.67e-22 94.0 2AGTB@1|root,3171D@2|Bacteria,1RJGM@1224|Proteobacteria,2UJ68@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_51628_2 1124654.G9L6D0_9CAUD 5.93e-77 264.0 4QC24@10239|Viruses,4QZPR@35237|dsDNA viruses no RNA stage,4QRZK@28883|Caudovirales,4QP0N@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_3266_1 318167.Sfri_1927 6.32e-14 72.4 COG2199@1|root,COG3706@2|Bacteria,1NC00@1224|Proteobacteria,1S49X@1236|Gammaproteobacteria,2Q9ZY@267890|Shewanellaceae 1236|Gammaproteobacteria T PFAM GGDEF domain containing protein - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_44410_1 1113547.A0A060D562_9CAUD 2.69e-145 437.0 4QFDB@10239|Viruses,4QVA2@35237|dsDNA viruses no RNA stage,4QTSF@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_44410_2 205879.Q854E1_BPMOM 7.8e-28 114.0 4QAIJ@10239|Viruses,4QVZ9@35237|dsDNA viruses no RNA stage,4QPXI@28883|Caudovirales,4QM02@10699|Siphoviridae 10699|Siphoviridae S C-5 cytosine-specific DNA methylase - - - - - - - - - - - - - k59_27277_1 330214.NIDE1826 1.62e-90 278.0 COG0654@1|root,COG0654@2|Bacteria,3J16C@40117|Nitrospirae 40117|Nitrospirae C FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_11505_1 45351.EDO46109 9.46e-71 246.0 KOG0621@1|root,KOG0621@2759|Eukaryota,38I3R@33154|Opisthokonta,3BBDE@33208|Metazoa 33208|Metazoa M phospholipid scrambling PLSCR3 GO:0000981,GO:0000982,GO:0001077,GO:0001228,GO:0001775,GO:0002237,GO:0002252,GO:0002376,GO:0002520,GO:0002526,GO:0002682,GO:0002684,GO:0002694,GO:0003674,GO:0003700,GO:0005102,GO:0005154,GO:0005215,GO:0005319,GO:0005488,GO:0005509,GO:0005515,GO:0005548,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006575,GO:0006629,GO:0006644,GO:0006650,GO:0006658,GO:0006659,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006915,GO:0006950,GO:0006952,GO:0006953,GO:0006954,GO:0006955,GO:0007009,GO:0007154,GO:0007165,GO:0007275,GO:0007596,GO:0007599,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009605,GO:0009607,GO:0009611,GO:0009615,GO:0009617,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010256,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010647,GO:0010876,GO:0010911,GO:0010912,GO:0010941,GO:0010942,GO:0012501,GO:0012505,GO:0015711,GO:0015748,GO:0015914,GO:0016020,GO:0016021,GO:0016043,GO:0016070,GO:0017121,GO:0017124,GO:0017128,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019899,GO:0019904,GO:0023051,GO:0023052,GO:0023056,GO:0030097,GO:0030099,GO:0030154,GO:0030168,GO:0031012,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031347,GO:0031349,GO:0031974,GO:0031981,GO:0032091,GO:0032496,GO:0032501,GO:0032502,GO:0032774,GO:0032781,GO:0033003,GO:0033036,GO:0033500,GO:0033993,GO:0034097,GO:0034641,GO:0034645,GO:0034654,GO:0035455,GO:0035456,GO:0035556,GO:0042060,GO:0042221,GO:0042398,GO:0042592,GO:0042593,GO:0042609,GO:0042632,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043393,GO:0043462,GO:0043900,GO:0043901,GO:0043903,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044271,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045017,GO:0045069,GO:0045071,GO:0045088,GO:0045089,GO:0045121,GO:0045893,GO:0045935,GO:0045944,GO:0046474,GO:0046483,GO:0046486,GO:0046872,GO:0048306,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048525,GO:0048534,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0048869,GO:0048878,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050792,GO:0050794,GO:0050817,GO:0050865,GO:0050878,GO:0050896,GO:0051098,GO:0051100,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051252,GO:0051254,GO:0051336,GO:0051345,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055088,GO:0055092,GO:0060255,GO:0060368,GO:0061024,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070782,GO:0070851,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071345,GO:0071396,GO:0071702,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0090407,GO:0097035,GO:0097190,GO:0097193,GO:0097194,GO:0097659,GO:0098542,GO:0098589,GO:0098805,GO:0098857,GO:0140110,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1901701,GO:1902229,GO:1902231,GO:1902531,GO:1902533,GO:1902680,GO:1903506,GO:1903508,GO:1903900,GO:1903901,GO:2000112,GO:2000371,GO:2000373,GO:2001020,GO:2001022,GO:2001141,GO:2001233,GO:2001235,GO:2001242,GO:2001244 - - - - - - - - - - Scramblase k59_11505_2 6087.XP_002169158.2 1.25e-43 156.0 2D12R@1|root,2SGHE@2759|Eukaryota,3AD4C@33154|Opisthokonta,3C0QR@33208|Metazoa 33154|Opisthokonta - - - - - - - - - - - - - - Pox_A32 k59_11505_3 7668.SPU_020023-tr 1.21e-60 208.0 COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa,3D8IP@33213|Bilateria 33208|Metazoa H Integrase core domain - - - - - - - - - - - - Chromo,rve k59_11505_7 45351.EDO33834 6.22e-21 103.0 2CTY1@1|root,2RI7I@2759|Eukaryota,3A3U7@33154|Opisthokonta,3BR67@33208|Metazoa 33208|Metazoa - - - - - - - - - - - - - - - k59_35946_1 7029.ACYPI069698-PA 2.62e-79 251.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3CWAK@33213|Bilateria,41WI3@6656|Arthropoda,3SIRK@50557|Insecta,3ECJT@33342|Paraneoptera 33208|Metazoa O K02A2.6-like - - - - - - - - - - - - Baculo_F,RVT_1,rve k59_34412_1 760154.Sulba_2291 7.22e-11 61.6 COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,42S81@68525|delta/epsilon subdivisions,2YPD7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - - - - - - - - - - SNARE_assoc k59_34412_2 1124983.PFLCHA0_c07880 3.14e-20 89.7 COG2207@1|root,COG2207@2|Bacteria,1R7PM@1224|Proteobacteria,1RYYY@1236|Gammaproteobacteria,1YRDC@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_46271_1 330214.NIDE1309 1.22e-187 528.0 COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae 40117|Nitrospirae J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis - - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_20011_1 330214.NIDE3281 2.13e-57 186.0 2AKTZ@1|root,31BM1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_30673_1 96561.Dole_1770 3.53e-30 120.0 COG2267@1|root,COG2267@2|Bacteria,1R9DT@1224|Proteobacteria,43AF1@68525|delta/epsilon subdivisions,2X5US@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_27293_1 1219375.CM002140_gene4242 0.000192 45.8 COG5611@1|root,COG5611@2|Bacteria,1RIZW@1224|Proteobacteria,1S6ZC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_32665_1 1301098.PKB_0468 1.88e-89 275.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_30681_1 316067.Geob_0975 6.33e-35 128.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - - - - - - - - - - - RVT_1 k59_15276_1 1401065.HMPREF2130_08495 1.98e-24 100.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,3T1W0@506|Alcaligenaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_15276_2 1552758.NC00_02020 7.34e-41 142.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1X40W@135614|Xanthomonadales 135614|Xanthomonadales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_30686_1 6412.HelroP172394 6.87e-52 182.0 2BNS1@1|root,2S1Q7@2759|Eukaryota,3A48Y@33154|Opisthokonta,3CP8W@33208|Metazoa,3E5DG@33213|Bilateria 33208|Metazoa - - - - - - - - - - - - - - - k59_49987_1 1298593.TOL_3562 4.44e-27 100.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1XJXC@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_49987_2 999141.GME_14665 6.15e-54 180.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XHZA@135619|Oceanospirillales 135619|Oceanospirillales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_25441_1 242861.Q6UYH2_9CAUD 4.31e-22 105.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_4478_1 1288494.EBAPG3_2060 4.09e-46 150.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,373HT@32003|Nitrosomonadales 28216|Betaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_4478_2 1163617.SCD_n00794 1.34e-59 202.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_48217_2 1589748.A0A0B5A5M2_9CAUD 1.9e-16 79.7 4QD50@10239|Viruses,4QPSB@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_11547_1 1283300.ATXB01000002_gene3146 1.47e-65 205.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria,1XFHM@135618|Methylococcales 135618|Methylococcales L PFAM IstB-like - - - - - - - - - - - - IstB_IS21 k59_6411_1 717774.Marme_3733 5.64e-25 110.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XHF9@135619|Oceanospirillales 135619|Oceanospirillales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_18477_1 330214.NIDE2463 1.65e-15 72.4 COG1758@1|root,COG1758@2|Bacteria,3J0UJ@40117|Nitrospirae 40117|Nitrospirae K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_18477_2 641149.HMPREF9016_01120 3.97e-26 107.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KPP0@206351|Neisseriales 206351|Neisseriales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_35639_5 1536592.A0A088F894_9VIRU 9.46e-14 67.0 4QAZF@10239|Viruses 10239|Viruses S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_4180_2 1121377.KB906402_gene3292 4.03e-05 50.1 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,HTH_31,N_BRCA1_IG ## 640 queries scanned ## Total time (seconds): 61.56956195831299 ## Rate: 10.39 q/s