## Sat Jan 4 07:26:35 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA629394/SRR11734714/SRR11734714_p_cluster_rep_seq.fasta --output PRJNA629394_SRR11734714 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_104293_1 279238.Saro_2801 1.09e-110 335.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2K1ZD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_91342_1 1049564.TevJSym_ai00390 1.32e-150 440.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1J4H8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_26598_1 933262.AXAM01000043_gene1176 2.82e-103 308.0 COG0111@1|root,COG0111@2|Bacteria,1QWPA@1224|Proteobacteria,42PTB@68525|delta/epsilon subdivisions,2WIT9@28221|Deltaproteobacteria,2MJ50@213118|Desulfobacterales 28221|Deltaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_71974_1 269799.Gmet_1553 1.05e-36 135.0 COG0577@1|root,COG0577@2|Bacteria,1R6DP@1224|Proteobacteria,42PWX@68525|delta/epsilon subdivisions,2WJSB@28221|Deltaproteobacteria,43TM4@69541|Desulfuromonadales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_71974_2 1125863.JAFN01000001_gene1445 6.02e-50 164.0 COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Predicted membrane protein (DUF2318) - - - - - - - - - - - - DUF2318 k59_84898_1 1049564.TevJSym_at00170 6.62e-127 379.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1JA1H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HDOD domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_84898_2 1049564.TevJSym_at00160 1.84e-131 384.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1J4EG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S AI-2E family transporter tqsA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 - ko:K11744 - - - - ko00000 - - - AI-2E_transport k59_84898_3 768671.ThimaDRAFT_0536 2.88e-23 95.9 2C8T8@1|root,32RMU@2|Bacteria,1N089@1224|Proteobacteria,1SAT4@1236|Gammaproteobacteria,1WYU4@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_84898_4 1049564.TevJSym_at00130 1.79e-123 354.0 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1J5Y1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25,2.7.7.4 ko:K00860,ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_201660_1 909663.KI867150_gene1321 4.26e-35 130.0 COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales 28221|Deltaproteobacteria KQ Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_123808_1 379731.PST_2764 2.84e-69 218.0 COG4336@1|root,COG4336@2|Bacteria,1MW52@1224|Proteobacteria,1RN4P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the D-glutamate cyclase family - - - - - - - - - - - - DUF1445 k59_13545_1 1249627.D779_1821 1.49e-68 210.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1WYEZ@135613|Chromatiales 135613|Chromatiales E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_13545_2 1049564.TevJSym_bf00160 7.16e-66 206.0 28P01@1|root,338A2@2|Bacteria,1NBSK@1224|Proteobacteria,1SS2R@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_78563_1 1121447.JONL01000005_gene1413 1.55e-89 271.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42Q3D@68525|delta/epsilon subdivisions,2WM24@28221|Deltaproteobacteria,2MGKS@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_11 k59_78563_2 706587.Desti_2315 1.12e-88 286.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MRGG@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_130359_1 765910.MARPU_14630 2.82e-80 251.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales 135613|Chromatiales U Type II secretion system - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_188627_1 1284775.HMPREF1640_00780 5.94e-05 52.8 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia 976|Bacteroidetes M Tricorn protease homolog - - - - - - - - - - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_33020_1 187272.Mlg_1695 3.59e-215 622.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,1WVWP@135613|Chromatiales 135613|Chromatiales T PFAM ATP-binding region - - - - - - - - - - - - HATPase_c,HisKA k59_110848_1 392500.Swoo_3537 4.51e-22 92.0 28PFH@1|root,2ZC6N@2|Bacteria,1RE9A@1224|Proteobacteria,1S4BF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4272) - - - - - - - - - - - - DUF4272 k59_110848_2 1392488.JHZY01000002_gene1034 4.18e-63 211.0 COG2826@1|root,COG2826@2|Bacteria,4NJ3V@976|Bacteroidetes,1I1RU@117743|Flavobacteriia 976|Bacteroidetes L Pfam Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_130362_1 1116472.MGMO_139c00050 2.51e-10 60.5 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1XDZA@135618|Methylococcales 135618|Methylococcales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_71987_1 1411123.JQNH01000001_gene2097 1.36e-15 80.9 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria 1224|Proteobacteria P ABC-type Fe3 transport system, periplasmic component - - - ko:K02012,ko:K11081 ko02010,map02010 M00190,M00302 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10,3.A.1.11.5 - - SBP_bac_6 k59_156208_1 1121396.KB893101_gene513 2.76e-41 146.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,2MHNM@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_117331_1 933262.AXAM01000004_gene2404 2.91e-74 231.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,2MIMF@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM ribosomal RNA methyltransferase RrmJ FtsJ tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_110853_1 991.IW20_11745 1.55e-05 49.3 COG0583@1|root,COG0583@2|Bacteria,4NJY4@976|Bacteroidetes,1IIQK@117743|Flavobacteriia,2NUFU@237|Flavobacterium 976|Bacteroidetes K Transcriptional regulator - - - ko:K11921 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_110853_2 675814.VIC_004862 8e-68 229.0 COG0369@1|root,COG0369@2|Bacteria,1QUAH@1224|Proteobacteria,1T1RJ@1236|Gammaproteobacteria,1XT6J@135623|Vibrionales 135623|Vibrionales P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_39476_1 243233.MCA2056 2.11e-38 140.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1XDK2@135618|Methylococcales 135618|Methylococcales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_39476_2 999141.GME_01544 3.77e-24 100.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1XJ47@135619|Oceanospirillales 135619|Oceanospirillales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_162761_1 706587.Desti_0964 3.38e-121 380.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_33025_1 1121403.AUCV01000059_gene3348 7.69e-26 108.0 COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,42S6Y@68525|delta/epsilon subdivisions,2WNZA@28221|Deltaproteobacteria,2MJV1@213118|Desulfobacterales 28221|Deltaproteobacteria S SBF-like CPA transporter family (DUF4137) - - - ko:K14347 - - - - ko00000,ko02000,ko04147 2.A.93.1 - - SBF_like k59_149765_1 492774.JQMB01000012_gene393 0.000233 46.2 COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,2TQQR@28211|Alphaproteobacteria,4BAW7@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - NB-ARC,Trans_reg_C k59_201690_1 1031288.AXAA01000052_gene757 2.74e-34 125.0 COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,36EJT@31979|Clostridiaceae 186801|Clostridia L uracil-DNA glycosylase udgA - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_188640_1 384765.SIAM614_29576 3.25e-36 128.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2U2IN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C hydrogenase expression formation protein hupD GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_117336_1 1167006.UWK_03347 4.62e-26 100.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,2MKW6@213118|Desulfobacterales 28221|Deltaproteobacteria K Regulatory protein - - - - - - - - - - - - MerR_1 k59_156212_1 1049564.TevJSym_be00330 5.02e-14 73.2 COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria,1RQR9@1236|Gammaproteobacteria,1J6IN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S outer membrane lipoprotein - - - - - - - - - - - - Rick_17kDa_Anti k59_65679_1 1121396.KB893080_gene906 6.89e-12 70.1 2D14X@1|root,32T9W@2|Bacteria,1N3UF@1224|Proteobacteria,42TU2@68525|delta/epsilon subdivisions,2WQH7@28221|Deltaproteobacteria,2MKH7@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_188885_1 1267005.KB911259_gene3766 1.01e-22 96.3 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2TU60@28211|Alphaproteobacteria,3N7EG@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_72193_1 56780.SYN_00584 4.09e-127 369.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2WJ4B@28221|Deltaproteobacteria,2MQW3@213462|Syntrophobacterales 28221|Deltaproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_20196_1 383372.Rcas_4207 1.24e-20 87.0 COG0745@1|root,COG0745@2|Bacteria,2GAT8@200795|Chloroflexi,3779Q@32061|Chloroflexia 32061|Chloroflexia T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_20196_2 986075.CathTA2_1256 1.84e-33 132.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HBZ0@91061|Bacilli 91061|Bacilli T Histidine kinase resE - 2.7.13.3 ko:K07651 ko02020,map02020 M00458 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_104531_2 761193.Runsl_4128 8.58e-16 81.6 COG0500@1|root,COG1246@1|root,COG1246@2|Bacteria,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,47MVN@768503|Cytophagia 976|Bacteroidetes Q Hypothetical methyltransferase arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_188888_1 933262.AXAM01000002_gene567 5.28e-62 215.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CoA-binding domain protein acs - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_195194_1 644968.DFW101_1414 8.54e-56 195.0 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M83U@213115|Desulfovibrionales 28221|Deltaproteobacteria KT SMART protein phosphatase 2C domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,SpoIIE k59_46147_2 1049564.TevJSym_ae00650 1.47e-159 452.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1J5P9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_46147_3 1265505.ATUG01000001_gene4007 8.36e-44 149.0 COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria,2MMDN@213118|Desulfobacterales 28221|Deltaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_46147_5 1165841.SULAR_00500 3.69e-145 449.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,42PHJ@68525|delta/epsilon subdivisions,2YNKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_46147_6 349521.HCH_06993 5.28e-160 460.0 COG1051@1|root,COG1056@1|root,COG1051@2|Bacteria,COG1056@2|Bacteria,1MWNH@1224|Proteobacteria,1RY71@1236|Gammaproteobacteria,1XINJ@135619|Oceanospirillales 135619|Oceanospirillales FH Bifunctional nicotinamide mononucleotide adenylyltransferase ADP-ribose pyrophosphatase - - 2.7.7.1 ko:K13522 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like,NUDIX k59_46147_7 1123504.JQKD01000002_gene3649 2.88e-07 51.2 COG1488@1|root,COG1488@2|Bacteria,1MWA2@1224|Proteobacteria,2VN4E@28216|Betaproteobacteria,4AGSR@80864|Comamonadaceae 28216|Betaproteobacteria H Nicotinate phosphoribosyltransferase (NAPRTase) family - - 2.4.2.12 ko:K03462 ko00760,ko01100,ko04621,map00760,map01100,map04621 - R01271 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_182423_1 1121405.dsmv_3230 9.5e-11 60.1 COG0250@1|root,COG0250@2|Bacteria,1QTE5@1224|Proteobacteria,42QT0@68525|delta/epsilon subdivisions,2WN4B@28221|Deltaproteobacteria,2MJNB@213118|Desulfobacterales 28221|Deltaproteobacteria K Transcription termination factor nusG - - - ko:K05785 - - - - ko00000,ko03000 - - - NusG k59_182423_2 1231190.NA8A_08974 2.73e-11 61.2 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,43KCK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_104533_1 870187.Thini_3395 6.98e-32 124.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,45ZS1@72273|Thiotrichales 72273|Thiotrichales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_59233_1 269799.Gmet_1934 8.43e-79 254.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,43UFS@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_7415_1 933262.AXAM01000025_gene3411 2.98e-51 172.0 COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales 28221|Deltaproteobacteria S nucleic acid binding OB-fold tRNA helicase-type yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon k59_97990_1 349124.Hhal_2161 1.61e-63 202.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,1S41X@1236|Gammaproteobacteria,1WVY2@135613|Chromatiales 135613|Chromatiales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_162988_1 195250.CM001776_gene520 1.07e-15 70.9 2EK16@1|root,33DRP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_162988_2 396588.Tgr7_1802 8.87e-88 267.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1WYF0@135613|Chromatiales 135613|Chromatiales L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_162988_3 745411.B3C1_04445 1.16e-08 58.2 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1J4N8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component ybbP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_130582_1 153948.NAL212_0091 1.77e-34 125.0 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2VQ90@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_124054_1 880072.Desac_0177 4.44e-62 202.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2MQ4M@213462|Syntrophobacterales 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_13733_2 1049564.TevJSym_ar00080 1.39e-129 375.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1J5JT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_13733_3 768671.ThimaDRAFT_3675 2e-92 280.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_162991_1 530564.Psta_1832 1.55e-125 370.0 COG3517@1|root,COG3517@2|Bacteria,2IXI1@203682|Planctomycetes 203682|Planctomycetes S TIGRFAM type VI secretion protein, EvpB VC_A0108 family - - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_78854_2 1216932.CM240_0529 4.55e-28 112.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,36DWB@31979|Clostridiaceae 186801|Clostridia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_59242_1 572477.Alvin_1199 3.41e-122 368.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_188907_1 879212.DespoDRAFT_03404 1.41e-90 279.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_39743_1 237368.SCABRO_02407 2.32e-74 237.0 COG0269@1|root,COG0684@1|root,COG0269@2|Bacteria,COG0684@2|Bacteria,2J0G2@203682|Planctomycetes 203682|Planctomycetes G Orotidine 5'-phosphate decarboxylase / HUMPS family - - 4.1.2.43 ko:K08093 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 M00345,M00580 R05338 RC00421,RC00422 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase,RraA-like k59_39743_2 880072.Desac_1177 1.49e-20 89.4 COG0794@1|root,COG0794@2|Bacteria,1RAT6@1224|Proteobacteria,4310K@68525|delta/epsilon subdivisions 1224|Proteobacteria G COGs COG0794 sugar phosphate isomerase involved in capsule formation - - 5.3.1.27 ko:K08094 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 M00345,M00580 R05339,R09780 RC00377 ko00000,ko00001,ko00002,ko01000 - - - SIS k59_137004_1 626887.J057_07486 4.98e-17 87.4 COG0501@1|root,COG0501@2|Bacteria,1NAW7@1224|Proteobacteria,1SFEN@1236|Gammaproteobacteria,46C96@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the peptidase M48B family - - - - - - - - - - - - Peptidase_M48 k59_7424_1 335543.Sfum_1361 3.67e-105 322.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria,2MQ6G@213462|Syntrophobacterales 28221|Deltaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_55068_1 644282.Deba_0780 5e-44 160.0 COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - Fer4_17,Fer4_8,Nitrate_red_gam k59_100507_1 443152.MDG893_05284 3.58e-09 58.5 28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,4667S@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_100507_2 1049564.TevJSym_aj00060 2.96e-141 430.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,1J98N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_62187_1 335543.Sfum_1173 1.5e-70 238.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_6,Pyr_redox_2 k59_81608_1 526222.Desal_1293 5.04e-82 259.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,42M9F@68525|delta/epsilon subdivisions,2WJNB@28221|Deltaproteobacteria,2M8DQ@213115|Desulfovibrionales 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_120796_1 1304885.AUEY01000003_gene539 7.32e-62 202.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MICX@213118|Desulfobacterales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_120796_2 340.xcc-b100_1653 7.84e-23 97.8 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1X3VD@135614|Xanthomonadales 135614|Xanthomonadales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_185508_1 1049564.TevJSym_aw00430 1.98e-95 283.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNWB@1236|Gammaproteobacteria,1J5BM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG1291 Flagellar motor component motC - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_95079_1 1134912.AJTV01000033_gene2292 6.5e-105 320.0 COG1196@1|root,COG3593@1|root,COG1196@2|Bacteria,COG3593@2|Bacteria,1MXAH@1224|Proteobacteria,2U2YR@28211|Alphaproteobacteria 28211|Alphaproteobacteria DL AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_15,AAA_21,DUF2813 k59_133444_1 1173028.ANKO01000195_gene5985 2.96e-44 166.0 COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,1H8J3@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_9 k59_100508_2 1049564.TevJSym_by00030 2.22e-73 241.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1J4T4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_10207_1 485916.Dtox_0554 1.51e-26 107.0 COG2243@1|root,COG2243@2|Bacteria,1TP87@1239|Firmicutes,249DM@186801|Clostridia,262ID@186807|Peptococcaceae 186801|Clostridia H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase cobI - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_23188_3 1120970.AUBZ01000002_gene857 2.29e-18 84.7 COG2165@1|root,COG2165@2|Bacteria,1N7HZ@1224|Proteobacteria,1SCWD@1236|Gammaproteobacteria,4672W@72275|Alteromonadaceae 1236|Gammaproteobacteria U general secretion pathway protein gspH GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02457 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspH,N_methyl k59_49018_1 644076.SCH4B_1136 2.77e-25 110.0 COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VFDY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_68582_2 1049564.TevJSym_av00170 3.27e-218 610.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_172117_2 269798.CHU_0987 2.19e-22 99.8 COG0661@1|root,COG0661@2|Bacteria,4NDUP@976|Bacteroidetes,47JE8@768503|Cytophagia 976|Bacteroidetes S unusual protein kinase - - - - - - - - - - - - ABC1,APH k59_120803_1 1415778.JQMM01000001_gene127 6.9e-35 132.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1J5RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_16000_1 158500.BV97_05789 1.6e-144 421.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales 204457|Sphingomonadales L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_3104_1 877455.Metbo_1478 4.74e-14 79.3 COG0484@1|root,COG2319@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG02491@2157|Archaea,arCOG02846@2157|Archaea 2157|Archaea O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - - - - - - - - - - Anticodon_1,Band_7_1,DUF835,PEGA,PQQ_2,zinc_ribbon_2 k59_74463_1 555779.Dthio_PD0896 8.59e-57 191.0 COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42Q8Y@68525|delta/epsilon subdivisions,2WK07@28221|Deltaproteobacteria,2M9WF@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - MFS_MOT1 k59_87829_1 765912.Thimo_0538 3.12e-24 106.0 COG0845@1|root,COG0845@2|Bacteria,1NKWA@1224|Proteobacteria,1RP0X@1236|Gammaproteobacteria,1WWQG@135613|Chromatiales 135613|Chromatiales M PFAM secretion protein HlyD - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_23190_1 335543.Sfum_2550 3.94e-171 493.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_43297_1 374847.Kcr_0881 3.12e-23 102.0 COG1824@1|root,arCOG00624@2157|Archaea 2157|Archaea P MgtE integral membrane mgtE2 - - ko:K07244 - - - - ko00000,ko02000 1.A.26.3 - iAF692.Mbar_A2809,iAF692.Mbar_A2810 MgtE k59_204460_2 1038869.AXAN01000121_gene499 7.56e-40 137.0 COG3436@1|root,COG3436@2|Bacteria,1RIKQ@1224|Proteobacteria,2VSKT@28216|Betaproteobacteria 28216|Betaproteobacteria L COG3436 Transposase and inactivated derivatives - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_204460_3 85643.Tmz1t_0281 3.95e-05 48.1 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,2VMF3@28216|Betaproteobacteria,2KXX9@206389|Rhodocyclales 206389|Rhodocyclales L Transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_55078_1 391735.Veis_4707 5.11e-65 200.0 COG4737@1|root,COG4737@2|Bacteria,1NAIM@1224|Proteobacteria,2VQB9@28216|Betaproteobacteria,4AFEF@80864|Comamonadaceae 28216|Betaproteobacteria S RelE toxin of RelE / RelB toxin-antitoxin system - - - - - - - - - - - - RelE k59_55078_2 391735.Veis_4706 6.96e-59 183.0 COG2944@1|root,COG2944@2|Bacteria,1N05Y@1224|Proteobacteria,2VSDE@28216|Betaproteobacteria,4AEHH@80864|Comamonadaceae 28216|Betaproteobacteria K Helix-turn-helix - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3,HTH_31 k59_16235_1 96561.Dole_1544 2.62e-43 150.0 COG1859@1|root,COG1859@2|Bacteria,1RD8B@1224|Proteobacteria,42TK9@68525|delta/epsilon subdivisions,2WQVQ@28221|Deltaproteobacteria,2MMDE@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM phosphotransferase KptA Tpt1 - - - ko:K07559 - - - - ko00000,ko01000,ko03016 - - - PTS_2-RNA k59_43601_1 933262.AXAM01000002_gene515 1.52e-57 189.0 COG4822@1|root,COG4822@2|Bacteria,1P36Y@1224|Proteobacteria,42P9C@68525|delta/epsilon subdivisions,2WK8C@28221|Deltaproteobacteria,2MIFS@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the insertion of Co(2 ) into sirohydrochlorin cbiKp GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016852,GO:0020037,GO:0022607,GO:0042597,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050897,GO:0051259,GO:0051262,GO:0051266,GO:0065003,GO:0071840,GO:0097159,GO:1901363 4.99.1.3 ko:K02190 ko00860,ko01100,map00860,map01100 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiK k59_36470_1 522306.CAP2UW1_1849 1.2e-14 71.6 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2VQH1@28216|Betaproteobacteria 28216|Betaproteobacteria K Two component transcriptional regulator, winged helix family creB - - ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_68865_1 335543.Sfum_0854 8.63e-57 193.0 COG3290@1|root,COG3852@1|root,COG3290@2|Bacteria,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,43BPS@68525|delta/epsilon subdivisions,2X710@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Signal transduction histidine kinase, nitrogen specific - - - - - - - - - - - - HATPase_c,HisKA k59_81811_3 1009370.ALO_03676 2.18e-42 142.0 COG4886@1|root,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus - - - - - - - - - - - - Gram_pos_anchor,Phage_GPD,Rib k59_16237_1 1121405.dsmv_0615 4.1e-23 101.0 COG1150@1|root,COG1150@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam k59_133665_1 1001585.MDS_2815 3.05e-79 251.0 COG3385@1|root,COG3385@2|Bacteria,1PQZT@1224|Proteobacteria,1TBQQ@1236|Gammaproteobacteria,1YIJZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_133665_2 1488328.JMCL01000057_gene1142 4.77e-127 376.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_185788_1 1049564.TevJSym_aw00530 6.04e-109 320.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1J68A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_185788_2 1168067.JAGP01000001_gene728 6.96e-28 103.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,1SCBG@1236|Gammaproteobacteria,4617Z@72273|Thiotrichales 72273|Thiotrichales N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_88015_3 498211.CJA_0015 4.98e-45 161.0 COG1305@1|root,COG1305@2|Bacteria,1NEY1@1224|Proteobacteria,1SF7F@1236|Gammaproteobacteria,1FHZ6@10|Cellvibrio 1236|Gammaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_88015_4 1192034.CAP_4354 1.04e-06 57.0 COG0402@1|root,COG4733@1|root,COG4935@1|root,COG0402@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,1QW0V@1224|Proteobacteria,42U6C@68525|delta/epsilon subdivisions,2WQX8@28221|Deltaproteobacteria,2Z3N3@29|Myxococcales 28221|Deltaproteobacteria DOZ Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix,Big_3_2,DUF4215 k59_10450_1 765913.ThidrDRAFT_3413 1.79e-16 78.2 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 9 - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_10450_2 1142394.PSMK_06300 0.000122 43.9 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_165688_1 1265505.ATUG01000001_gene4505 3.36e-100 300.0 COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria,2MJJZ@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H k59_121088_1 1049564.TevJSym_ac01200 6.95e-130 386.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1J4HD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_10451_1 1049564.TevJSym_bj00040 1.09e-09 64.7 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1J5S7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaQ GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975 Glyco_transf_9 k59_16247_1 1121405.dsmv_0421 3.22e-98 296.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2MI9F@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family bamN - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_74704_1 1347087.CBYO010000017_gene2734 7.42e-05 53.5 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes 1239|Firmicutes O COG1404 Subtilisin-like serine proteases bpr GO:0005575,GO:0005576 - ko:K13276 - - - - ko00000,ko01000,ko01002,ko03110 - - - CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8 k59_133672_1 1296416.JACB01000052_gene2812 7.76e-15 75.5 COG4251@1|root,COG4251@2|Bacteria,4PM7A@976|Bacteroidetes,1IJK9@117743|Flavobacteriia,2YM57@290174|Aquimarina 976|Bacteroidetes T PAS domain - - - - - - - - - - - - GAF,HATPase_c,HNOBA,HisKA,PAS_3,PAS_9,Response_reg k59_133672_2 439235.Dalk_0718 1e-25 99.8 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MM20@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein family usp-2 - - ko:K06149 - - - - ko00000 - - - Usp k59_179061_1 706587.Desti_1415 6.47e-74 234.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2MQXW@213462|Syntrophobacterales 28221|Deltaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_43625_1 519989.ECTPHS_14156 2.44e-50 166.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_62460_1 1049564.TevJSym_bb00290 0.0 900.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_62460_2 1249627.D779_0034 1.76e-50 168.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria,1WX12@135613|Chromatiales 135613|Chromatiales KT response regulator receiver - - - - - - - - - - - - PAS,PAS_9,Response_reg k59_121096_1 1303518.CCALI_01394 1.74e-36 137.0 COG1639@1|root,COG1639@2|Bacteria 2|Bacteria T HDOD domain - - - - - - - - - - - - HDOD k59_36477_2 768066.HELO_3995 9.64e-26 112.0 COG1444@1|root,COG1444@2|Bacteria,1NBA4@1224|Proteobacteria,1RPAM@1236|Gammaproteobacteria,1XHGK@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) tmcA - 2.3.1.193 ko:K06957 - - - - ko00000,ko01000,ko03016 - - - DUF1726,GNAT_acetyltr_2,Helicase_RecD,tRNA_bind_3 k59_146523_5 1121943.KB900001_gene2978 1.66e-42 149.0 COG2003@1|root,COG2003@2|Bacteria,1N0JY@1224|Proteobacteria,1SNVI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L RadC-like JAB domain - - - - - - - - - - - - RadC k59_146523_8 270374.MELB17_05544 4.05e-29 106.0 COG1476@1|root,COG1476@2|Bacteria,1QUQ3@1224|Proteobacteria,1SADW@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain higA - - - - - - - - - - - HTH_3,HTH_31 k59_197866_1 83406.HDN1F_27950 5.23e-88 278.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,1RY6S@1236|Gammaproteobacteria,1J7NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_43626_2 998674.ATTE01000001_gene2324 1.31e-20 84.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,460R0@72273|Thiotrichales 72273|Thiotrichales C Iron--sulfur cluster insertion protein erpA erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_165692_1 768671.ThimaDRAFT_2243 2.94e-101 311.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales 135613|Chromatiales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_100676_3 310453.XP_007588647.1 1.26e-43 160.0 2D1FR@1|root,2SHYF@2759|Eukaryota,38I9S@33154|Opisthokonta,3NWW1@4751|Fungi,3QSKK@4890|Ascomycota,203G5@147541|Dothideomycetes 4751|Fungi - - - - - - - - - - - - - - DUF2236 k59_100676_4 640511.BC1002_4166 6.74e-64 211.0 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VZJ0@28216|Betaproteobacteria,1K5IG@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_159488_1 472759.Nhal_0408 2.54e-55 188.0 COG1847@1|root,COG3854@1|root,COG1847@2|Bacteria,COG3854@2|Bacteria,1MWTB@1224|Proteobacteria,1RS72@1236|Gammaproteobacteria,1X0GN@135613|Chromatiales 135613|Chromatiales S single-stranded nucleic acid binding R3H - - - - - - - - - - - - AAA,R3H k59_146526_1 1121403.AUCV01000054_gene2606 9.72e-104 311.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,2MJ8Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Hydrogenase (NiFe) small subunit HydA hynB - 1.12.2.1,1.12.5.1,1.12.99.6 ko:K05927,ko:K06282,ko:K18008 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_81832_1 192952.MM_1806 5.4e-39 139.0 COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2N9I4@224756|Methanomicrobia 224756|Methanomicrobia S PAC2 family - - - ko:K07159 - - - - ko00000 - - - PAC2 k59_26420_1 880073.Calab_0683 3.08e-48 179.0 COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - Big_5,CarboxypepD_reg,DUF11,LRR_5,Peptidase_S8,SLH k59_168922_1 1163617.SCD_n00525 6.84e-35 125.0 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2VMVW@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_168922_2 1163617.SCD_n00526 3.99e-77 234.0 COG2128@1|root,COG2128@2|Bacteria,1RHU7@1224|Proteobacteria,2VYYI@28216|Betaproteobacteria 28216|Betaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_26423_1 314232.SKA53_12438 1.14e-14 77.8 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,2P81Y@245186|Loktanella 28211|Alphaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_6961_2 565033.GACE_0184 2.94e-21 92.0 2DZ6G@1|root,2N57Y@2157|Archaea,2Y4M8@28890|Euryarchaeota,2479K@183980|Archaeoglobi 183980|Archaeoglobi - - - - - - - - - - - - - - - k59_65233_1 1049564.TevJSym_ba00070 1.79e-07 50.8 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1J63S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iJN746.PP_1602 FabA k59_65233_2 1249627.D779_1895 9.49e-107 317.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1WX0R@135613|Chromatiales 135613|Chromatiales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_91214_1 394503.Ccel_1332 2.83e-25 99.8 COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_91214_2 266779.Meso_2667 0.000208 46.2 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,43HNC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P heavy metal translocating P-type ATPase actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_26428_1 1121939.L861_11290 5.39e-67 213.0 28Q4X@1|root,2ZCN0@2|Bacteria,1RA2A@1224|Proteobacteria,1S3SD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_26428_2 2340.JV46_18040 3.33e-57 187.0 COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,1S48U@1236|Gammaproteobacteria,1JBT0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_26428_3 1283284.AZUK01000001_gene1441 5.88e-10 56.6 COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,1SH4J@1236|Gammaproteobacteria,1Y67S@135624|Aeromonadales 135624|Aeromonadales S Transmembrane anti-sigma factor - - - - - - - - - - - - - k59_188453_1 1121405.dsmv_0170 1.15e-106 327.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_110636_1 443143.GM18_0518 1.74e-64 208.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42TVH@68525|delta/epsilon subdivisions,2WR7Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_110636_2 1282360.ABAC460_17880 5.86e-88 273.0 COG0863@1|root,COG0863@2|Bacteria,1RAU2@1224|Proteobacteria,2UH7S@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Eco29kI restriction endonuclease - - - - - - - - - - - - RE_Eco29kI k59_110636_3 1282360.ABAC460_17875 6.61e-56 178.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2UA6G@28211|Alphaproteobacteria,2KGWM@204458|Caulobacterales 204458|Caulobacterales L May nick specific sequences that contain T G mispairs resulting from m5C-deamination - - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - Vsr k59_110636_5 360910.BAV0370 2.53e-16 73.6 294HZ@1|root,2ZRXM@2|Bacteria,1P8SB@1224|Proteobacteria,2WDBW@28216|Betaproteobacteria,3T8ED@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_110636_6 380358.XALC_2637 2.08e-96 285.0 2E672@1|root,330VM@2|Bacteria,1N961@1224|Proteobacteria,1SSIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial mobilisation protein (MobC) - - - - - - - - - - - - MobC k59_110636_8 160492.XF_a0049 1.02e-05 49.7 2AH0P@1|root,33KW8@2|Bacteria,1NNQ4@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_110636_9 1348657.M622_18590 3.64e-149 421.0 2CJX8@1|root,2ZAA9@2|Bacteria,1RFA5@1224|Proteobacteria,2VS1G@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_65262_1 203122.Sde_0972 3.39e-45 148.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,467UW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_65262_3 1049564.TevJSym_aa00130 2.74e-60 186.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1J6C1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_65262_4 998088.B565_0193 2.04e-56 177.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1Y4FZ@135624|Aeromonadales 135624|Aeromonadales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_149576_1 177437.HRM2_34780 6.96e-79 241.0 COG2050@1|root,COG2050@2|Bacteria,1N57X@1224|Proteobacteria,431HH@68525|delta/epsilon subdivisions,2WW6Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_3 k59_123617_1 439481.Aboo_1381 4.48e-57 202.0 COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,3F2HY@33867|unclassified Euryarchaeota 28890|Euryarchaeota D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_45821_1 243231.GSU0285 8.11e-64 209.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_19918_2 1123279.ATUS01000001_gene1674 1.25e-101 300.0 COG1216@1|root,COG1216@2|Bacteria,1QY6A@1224|Proteobacteria,1T4RR@1236|Gammaproteobacteria,1J9BB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase family - - - - - - - - - - - - - k59_19918_6 94122.Shewana3_2478 3.03e-12 65.1 2E5B0@1|root,33033@2|Bacteria,1ND0X@1224|Proteobacteria,1SEBX@1236|Gammaproteobacteria,2QCZS@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_19918_8 373994.Riv7116_0611 9.29e-13 65.1 COG1670@1|root,COG1670@2|Bacteria,1GR52@1117|Cyanobacteria 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - 2.3.1.82 ko:K18816 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1 k59_19918_9 305700.B447_10058 9.62e-83 249.0 COG0406@1|root,COG0406@2|Bacteria,1N0M0@1224|Proteobacteria,2VVWH@28216|Betaproteobacteria,2KZAF@206389|Rhodocyclales 206389|Rhodocyclales G phosphoglycerate mutase - - - - - - - - - - - - - k59_19918_10 159087.Daro_2533 3.83e-97 289.0 COG0346@1|root,COG0346@2|Bacteria,1RD81@1224|Proteobacteria,2VVM9@28216|Betaproteobacteria 28216|Betaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_3 k59_19918_11 1052684.PPM_3452 4.62e-56 177.0 COG1942@1|root,COG1942@2|Bacteria,1VNNE@1239|Firmicutes,4HXBB@91061|Bacilli,26YRP@186822|Paenibacillaceae 91061|Bacilli S Tautomerase enzyme - - - - - - - - - - - - Tautomerase_2 k59_13401_4 1049564.TevJSym_ab01360 9.2e-148 452.0 COG0642@1|root,COG0642@2|Bacteria,1QU3Z@1224|Proteobacteria,1T311@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - CBM9_1,HATPase_c,HisKA k59_78395_1 584708.Apau_0585 1.19e-28 114.0 COG3039@1|root,COG3039@2|Bacteria,3TBCF@508458|Synergistetes 508458|Synergistetes L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_26430_1 324925.Ppha_2533 1.7e-74 242.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_4 k59_136591_1 392500.Swoo_0198 1.65e-36 154.0 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,2QAGA@267890|Shewanellaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_136591_2 1123400.KB904790_gene224 6.52e-29 124.0 COG1372@1|root,COG3209@1|root,COG1372@2|Bacteria,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,461AK@72273|Thiotrichales 72273|Thiotrichales M rhs family - - - - - - - - - - - - RHS_repeat k59_136591_3 742742.HMPREF9452_00763 6.81e-06 46.6 2EI2G@1|root,33BTW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_136591_7 1279017.AQYJ01000020_gene1294 1.18e-118 378.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG1404 Subtilisin-like serine proteases - GO:0005575,GO:0005576 - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PKD,PPC,P_proprotein,Peptidase_S8 k59_97678_2 488538.SAR116_1850 1.2e-17 79.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,4BQRD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_6984_1 1380391.JIAS01000005_gene2454 4.33e-20 94.4 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,2TVGJ@28211|Alphaproteobacteria,2JPR0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_91228_1 1121405.dsmv_1656 2.11e-43 146.0 COG2010@1|root,COG2010@2|Bacteria,1QSQ1@1224|Proteobacteria,437J9@68525|delta/epsilon subdivisions,2X2T9@28221|Deltaproteobacteria,2MNXV@213118|Desulfobacterales 28221|Deltaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_143305_1 754476.Q7A_1581 1.5e-94 286.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,460H0@72273|Thiotrichales 72273|Thiotrichales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_143305_2 1301098.PKB_0441 4.25e-27 104.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S3RF@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome b561 yceJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_39563_1 748449.Halha_0061 1.34e-44 162.0 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,3WAJV@53433|Halanaerobiales 186801|Clostridia L TIGRFAM DNA polymerase III, delta holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_84997_1 1537917.JU82_05045 3.05e-35 135.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,42P71@68525|delta/epsilon subdivisions,2YNAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_84997_2 998674.ATTE01000001_gene1698 6.95e-15 73.2 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,45ZT6@72273|Thiotrichales 72273|Thiotrichales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_156305_1 338963.Pcar_0324 1.46e-94 292.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,43S0F@69541|Desulfuromonadales 28221|Deltaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_13642_2 573061.Clocel_0123 7.87e-07 50.4 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,36FHM@31979|Clostridiaceae 186801|Clostridia N PFAM OmpA MotB domain protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_26718_1 1235835.C814_03068 9.96e-06 48.1 COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,3WHGN@541000|Ruminococcaceae 186801|Clostridia K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_46070_1 1049564.TevJSym_aw00170 9.36e-70 213.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the DsrF TusC family tusC GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_46070_2 395493.BegalDRAFT_1370 3.16e-15 70.5 COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,462S7@72273|Thiotrichales 72273|Thiotrichales P DsrE/DsrF-like family - - - ko:K07235 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE k59_136879_2 1122139.KB907884_gene371 2.33e-09 57.8 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1XIGX@135619|Oceanospirillales 135619|Oceanospirillales C formate dehydrogenase fdsA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_143313_1 96561.Dole_3221 1.1e-104 313.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,42MEN@68525|delta/epsilon subdivisions,2WIYF@28221|Deltaproteobacteria,2MIJH@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_169261_1 933262.AXAM01000078_gene1610 5.88e-93 282.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42NHN@68525|delta/epsilon subdivisions,2WJ4S@28221|Deltaproteobacteria,2MHWJ@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM cytochrome d ubiquinol oxidase, subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_104397_1 1336245.JAGO01000010_gene819 1.63e-56 189.0 COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,1RMQY@1236|Gammaproteobacteria,1XRS3@135619|Oceanospirillales 135619|Oceanospirillales Q Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB - - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 k59_104397_2 1049564.TevJSym_ab00170 4.66e-178 508.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_136883_1 1122947.FR7_2907 3.5e-67 218.0 COG3007@1|root,COG3007@2|Bacteria,1TWIF@1239|Firmicutes,4H2XT@909932|Negativicutes 909932|Negativicutes I NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - - - - - - - - - - Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase k59_20109_1 546275.FUSPEROL_02391 2.39e-09 61.2 COG0452@1|root,COG0452@2|Bacteria,37970@32066|Fusobacteria 32066|Fusobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_20109_2 631362.Thi970DRAFT_00100 4.62e-35 128.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_130442_1 1047013.AQSP01000126_gene2727 5.05e-23 89.0 COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria 2|Bacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_87201_1 671143.DAMO_2029 6.52e-84 260.0 COG5421@1|root,COG5421@2|Bacteria,2NQ27@2323|unclassified Bacteria 2|Bacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_67837_1 1121405.dsmv_2227 7.5e-153 452.0 28HQ2@1|root,2Z7XV@2|Bacteria,1P4Z7@1224|Proteobacteria,42NSG@68525|delta/epsilon subdivisions,2WJ6K@28221|Deltaproteobacteria,2MJCF@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_48306_2 1298858.AUEL01000032_gene3843 2.79e-29 120.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,43HQY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9 k59_99824_1 765910.MARPU_15110 1.28e-135 400.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_99824_2 1216966.BAUC01000023_gene1505 1.86e-27 105.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria 1236|Gammaproteobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131 HPPK k59_126621_1 1049564.TevJSym_ap00800 1.56e-27 107.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1J4RX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA k59_178175_1 314345.SPV1_00742 9.82e-60 189.0 COG1309@1|root,COG1309@2|Bacteria,1N1KX@1224|Proteobacteria 1224|Proteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_6,TetR_N k59_158514_1 1027273.GZ77_20140 3.41e-11 63.9 COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1XMAP@135619|Oceanospirillales 135619|Oceanospirillales S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_139001_2 1304872.JAGC01000003_gene2740 3.02e-19 87.8 COG5000@1|root,COG5000@2|Bacteria,1QUN4@1224|Proteobacteria,43BMS@68525|delta/epsilon subdivisions,2X76D@28221|Deltaproteobacteria,2MGW9@213115|Desulfovibrionales 28221|Deltaproteobacteria T Multi-sensor signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,sCache_3_2 k59_54770_4 1101195.Meth11DRAFT_0121 2.95e-47 167.0 COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2VMT6@28216|Betaproteobacteria,2KNSS@206350|Nitrosomonadales 206350|Nitrosomonadales U Flp pilus assembly protein RcpC/CpaB - - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_54770_6 555778.Hneap_2309 6.13e-200 577.0 COG1716@1|root,COG4962@1|root,COG1716@2|Bacteria,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1WXRJ@135613|Chromatiales 135613|Chromatiales U type II secretion system protein E - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - FHA,T2SSE k59_54770_8 535289.Dtpsy_2114 4.11e-87 269.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VPMR@28216|Betaproteobacteria,4AE2C@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM type II secretion system - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_54770_11 326297.Sama_0712 5.51e-06 49.7 COG0457@1|root,COG0457@2|Bacteria,1NHI4@1224|Proteobacteria,1SH4R@1236|Gammaproteobacteria,2QC0Y@267890|Shewanellaceae 1236|Gammaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16 k59_106925_2 1122612.AUBA01000015_gene888 1.48e-85 270.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2U5D5@28211|Alphaproteobacteria,2K1C7@204457|Sphingomonadales 204457|Sphingomonadales C Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process - - 1.17.99.1 ko:K05797 ko00623,ko01100,ko01120,map00623,map01100,map01120 - R02675,R11194 RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_42717_1 1049564.TevJSym_ag00110 1.06e-42 162.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_106926_1 338963.Pcar_1849 4.91e-22 92.8 COG3216@1|root,COG3216@2|Bacteria,1QEG2@1224|Proteobacteria,42VUY@68525|delta/epsilon subdivisions,2WRD1@28221|Deltaproteobacteria,43SKM@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_197291_1 1121438.JNJA01000004_gene925 7.06e-63 209.0 COG2204@1|root,COG2204@2|Bacteria,1MVWX@1224|Proteobacteria,42MIB@68525|delta/epsilon subdivisions,2WJQK@28221|Deltaproteobacteria,2M80M@213115|Desulfovibrionales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator - - - ko:K02481 - - - - ko00000,ko02022 - - - Response_reg,Sigma54_activat k59_113370_1 1232410.KI421417_gene2727 2.33e-20 97.8 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2X2B8@28221|Deltaproteobacteria,43U8G@69541|Desulfuromonadales 28221|Deltaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - - - - - - - - - - Toluene_X k59_139004_1 1232410.KI421421_gene3325 1.25e-43 156.0 COG3635@1|root,COG3635@2|Bacteria,1R2SD@1224|Proteobacteria,42NR6@68525|delta/epsilon subdivisions,2WJZY@28221|Deltaproteobacteria,43U1P@69541|Desulfuromonadales 28221|Deltaproteobacteria G 2,3-bisphosphoglycerate-independent phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_74129_1 1123371.ATXH01000028_gene21 3.86e-43 147.0 COG1100@1|root,COG1100@2|Bacteria,2GIDK@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Ras family - - - ko:K06883 - - - - ko00000 - - - Arf k59_145983_1 645991.Sgly_3341 4.12e-30 115.0 2DQF9@1|root,336H4@2|Bacteria,1VJH7@1239|Firmicutes,2541D@186801|Clostridia,265YM@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_204115_1 1232437.KL662076_gene3497 2.08e-71 232.0 COG2885@1|root,COG3267@1|root,COG2885@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42PJ3@68525|delta/epsilon subdivisions,2WJF6@28221|Deltaproteobacteria,2MJ4S@213118|Desulfobacterales 28221|Deltaproteobacteria MU AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,OmpA k59_94620_1 457398.HMPREF0326_02660 2.47e-18 94.4 COG4227@1|root,COG4643@1|root,COG4227@2|Bacteria,COG4643@2|Bacteria,1MU8I@1224|Proteobacteria,42N43@68525|delta/epsilon subdivisions,2WM7N@28221|Deltaproteobacteria,2M823@213115|Desulfovibrionales 28221|Deltaproteobacteria L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738,Toprim_3 k59_87412_1 589865.DaAHT2_0807 2.67e-48 169.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MIPJ@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_133125_1 1121396.KB893084_gene404 3.65e-69 216.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2MK1Y@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_133125_2 1131730.BAVI_09791 1.64e-20 87.8 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli,1ZMJ5@1386|Bacillus 91061|Bacilli E ABC transporter - - - - - - - - - - - - ABC_tran k59_191253_1 1049564.TevJSym_ba00240 1.47e-13 66.6 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity gloA - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_191253_2 795666.MW7_2391 5.54e-07 53.5 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,1JZPC@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR family oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_106930_1 1437882.AZRU01000026_gene6003 1.78e-06 53.9 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,1RPQ2@1236|Gammaproteobacteria,1YDZM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Intracellular multiplication and human macrophage-killing icmF1 - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N k59_100086_1 765910.MARPU_00035 2.24e-19 89.7 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales 135613|Chromatiales P Chloride channel - - - - - - - - - - - - Voltage_CLC k59_145990_1 313612.L8106_03989 1.07e-11 70.1 COG2199@1|root,COG2202@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1FZWU@1117|Cyanobacteria,1H8MG@1150|Oscillatoriales 1117|Cyanobacteria T GGDEF domain' - - - - - - - - - - - - CBS,GAF,GAF_2,GGDEF,PAS_3,PAS_8,PAS_9 k59_158831_1 335543.Sfum_3487 4.36e-12 66.6 COG2885@1|root,COG3221@1|root,COG2885@2|Bacteria,COG3221@2|Bacteria,1R687@1224|Proteobacteria,42ZCB@68525|delta/epsilon subdivisions,2WTSU@28221|Deltaproteobacteria 28221|Deltaproteobacteria MP NMT1/THI5 like - - - - - - - - - - - - NMT1,OmpA k59_158831_3 335543.Sfum_3489 7.12e-52 179.0 COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,1QU25@1224|Proteobacteria,42YRH@68525|delta/epsilon subdivisions,2WUGB@28221|Deltaproteobacteria 28221|Deltaproteobacteria P NMT1/THI5 like - - - - - - - - - - - - NMT1 k59_61803_1 96561.Dole_3091 4.68e-92 279.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,42TG6@68525|delta/epsilon subdivisions,2WQ8T@28221|Deltaproteobacteria,2MNB0@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_9856_1 304371.MCP_1288 1.73e-31 135.0 arCOG06516@1|root,arCOG06712@1|root,arCOG06516@2157|Archaea,arCOG06712@2157|Archaea,2XYJJ@28890|Euryarchaeota 28890|Euryarchaeota T Pas domain s-box - - - - - - - - - - - - DUF835,HAMP,HATPase_c,PAS,PAS_9 k59_2826_1 449447.MAE_03350 5.53e-19 89.7 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G0GB@1117|Cyanobacteria 1117|Cyanobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_32,HTH_33 k59_2826_2 272558.10175140 2.59e-08 56.2 COG3335@1|root,COG3335@2|Bacteria,1V41H@1239|Firmicutes,4HH52@91061|Bacilli,1ZHKF@1386|Bacillus 91061|Bacilli L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_29,HTH_33 k59_165144_1 765913.ThidrDRAFT_0367 2.61e-62 198.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales 135613|Chromatiales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_68172_1 1232437.KL662064_gene4039 3.46e-14 72.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,42NCP@68525|delta/epsilon subdivisions,2WJSM@28221|Deltaproteobacteria,2MI5K@213118|Desulfobacterales 28221|Deltaproteobacteria M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_42726_1 1202962.KB907150_gene1490 3.26e-64 202.0 COG0454@1|root,COG0454@2|Bacteria,1QYXF@1224|Proteobacteria,1T3WM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Protein conserved in bacteria - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_42726_3 1336243.JAEA01000005_gene1506 2.83e-40 141.0 COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,2U72S@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like k59_133131_1 439235.Dalk_1015 9.75e-62 208.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42NGP@68525|delta/epsilon subdivisions,2WIZN@28221|Deltaproteobacteria,2MHUU@213118|Desulfobacterales 28221|Deltaproteobacteria N basal body rod protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_9857_1 1123279.ATUS01000002_gene17 7.35e-128 385.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1J4WH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0514 Superfamily II DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_106935_1 933262.AXAM01000085_gene1063 3.26e-70 218.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MI7G@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_48648_1 1121456.ATVA01000001_gene3068 1.33e-81 260.0 COG4191@1|root,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria,2M8NY@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_191264_1 1049564.TevJSym_ac00760 3.65e-68 223.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,1J500@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_54787_1 1144672.F966_00451 3.02e-40 146.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_81253_1 309803.CTN_1609 5.61e-16 81.3 COG0582@1|root,COG0582@2|Bacteria,2GDJZ@200918|Thermotogae 200918|Thermotogae L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_integrase k59_152313_2 96561.Dole_2741 2.05e-40 137.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MJTB@213118|Desulfobacterales 28221|Deltaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_35852_1 1033738.CAEP01000029_gene1765 1.81e-11 69.3 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,4H9M3@91061|Bacilli,26EQQ@186818|Planococcaceae 91061|Bacilli EK COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_29079_1 1122604.JONR01000009_gene2309 3.39e-45 159.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 k59_133133_1 1049564.TevJSym_ar00430 6.84e-24 100.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4MB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_133133_2 1278309.KB907109_gene3293 1.83e-44 153.0 COG3709@1|root,COG3709@2|Bacteria,1RGXZ@1224|Proteobacteria,1S3VA@1236|Gammaproteobacteria,1XKCD@135619|Oceanospirillales 135619|Oceanospirillales P Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) phnN - 2.7.4.23 ko:K05774 ko00030,map00030 - R06836 RC00002 ko00000,ko00001,ko01000 - - - AAA_33 k59_178474_1 1500890.JQNL01000001_gene1171 2.67e-47 157.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1X6GZ@135614|Xanthomonadales 135614|Xanthomonadales K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_15678_1 1049564.TevJSym_bu00070 7.51e-89 263.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1J5V2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_42743_1 1049564.TevJSym_as00140 1.08e-164 469.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_42743_2 1429851.X548_15080 0.000272 43.5 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1X6BT@135614|Xanthomonadales 135614|Xanthomonadales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_133137_1 1121456.ATVA01000015_gene2238 8.48e-52 181.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2M89U@213115|Desulfovibrionales 28221|Deltaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_35856_1 1496688.ER33_04340 1.31e-12 68.2 COG0514@1|root,COG0514@2|Bacteria,1G1Y1@1117|Cyanobacteria,22SHJ@167375|Cyanobium 1117|Cyanobacteria L RQC recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_204294_1 1049564.TevJSym_aa02130 2.25e-113 333.0 2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - MotA_ExbB k59_10032_1 1121405.dsmv_2911 1.6e-34 127.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MI7G@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_10032_2 1232410.KI421420_gene3180 1.77e-17 79.7 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,43SSF@69541|Desulfuromonadales 28221|Deltaproteobacteria U mttA/Hcf106 family tatB - - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_43046_1 156889.Mmc1_1519 3.24e-51 183.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K exporters of the RND superfamily MA20_16090 - - ko:K07003 - - - - ko00000 - - - MMPL k59_54979_1 153721.MYP_379 1.76e-36 134.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,47Q96@768503|Cytophagia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_36039_1 1049564.TevJSym_au00160 1.06e-120 363.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_172049_1 324925.Ppha_2765 4.03e-30 111.0 COG0745@1|root,COG0745@2|Bacteria,1FFE8@1090|Chlorobi 1090|Chlorobi T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_107197_1 653733.Selin_0306 5.94e-17 85.1 COG1322@1|root,COG1322@2|Bacteria 2|Bacteria S DNA recombination rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_43047_1 396588.Tgr7_1108 6.16e-49 160.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1S73Y@1236|Gammaproteobacteria,1X24K@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_43047_2 317025.Tcr_0783 1.62e-42 150.0 COG0225@1|root,COG0229@1|root,COG0526@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,COG0526@2|Bacteria,1MVUS@1224|Proteobacteria,1T0T1@1236|Gammaproteobacteria,460U4@72273|Thiotrichales 72273|Thiotrichales CO Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR,Thioredoxin_2 k59_159045_1 596151.DesfrDRAFT_2501 6.33e-68 217.0 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,42NAT@68525|delta/epsilon subdivisions,2WPPB@28221|Deltaproteobacteria,2MBTW@213115|Desulfovibrionales 28221|Deltaproteobacteria V Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_206176_11 762966.HMPREF9439_02039 5.83e-24 110.0 28KC1@1|root,2Z9Z1@2|Bacteria,1MW96@1224|Proteobacteria,2VNCU@28216|Betaproteobacteria,4PRVS@995019|Sutterellaceae 28216|Betaproteobacteria S Type-1V conjugative transfer system mating pair stabilisation traN - - ko:K12058 - - - - ko00000,ko02044 3.A.7.11.1 - - TraN k59_206176_12 1454004.AW11_03860 4.04e-65 210.0 COG0526@1|root,COG0526@2|Bacteria,1MXG2@1224|Proteobacteria,2VMSV@28216|Betaproteobacteria 28216|Betaproteobacteria CO F plasmid transfer operon protein traF - - ko:K12057 - - - - ko00000,ko02044 3.A.7.11.1 - - TraF k59_206176_13 91604.ID47_01325 4.39e-88 284.0 28MTB@1|root,2ZB1J@2|Bacteria,1MWD0@1224|Proteobacteria,2UGCF@28211|Alphaproteobacteria,47GRW@766|Rickettsiales 766|Rickettsiales S Conjugative relaxosome accessory transposon protein - - - ko:K12072 - - - - ko00000,ko02044 3.A.7.11.1 - - TraH k59_206176_14 985867.AEWF01000009_gene1143 5.8e-63 238.0 COG4678@1|root,COG4678@2|Bacteria,1MXCR@1224|Proteobacteria,2U372@28211|Alphaproteobacteria,47GSX@766|Rickettsiales 766|Rickettsiales G TraG-like protein, N-terminal region - - - ko:K12056 - - - - ko00000,ko02044 3.A.7.11.1 - - TraG_N k59_135329_2 666681.M301_2184 8.55e-67 213.0 COG0558@1|root,COG0558@2|Bacteria,1RE0I@1224|Proteobacteria,2VR68@28216|Betaproteobacteria 28216|Betaproteobacteria I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_193314_1 1049564.TevJSym_an00460 2.71e-121 353.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1J562@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0685 5,10-methylenetetrahydrofolate reductase metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0117,iSBO_1134.SBO_3961 MTHFR k59_193314_2 261292.Nit79A3_2869 6.57e-19 88.6 COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,372IW@32003|Nitrosomonadales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_7,PAS_9,Response_reg,dCache_1 k59_25291_2 1049564.TevJSym_ac01780 3.74e-07 50.4 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1J4IP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_12323_1 225849.swp_0354 7.32e-62 201.0 28IWG@1|root,2Z8US@2|Bacteria,1NHDW@1224|Proteobacteria,1RR5V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_51030_1 1158292.JPOE01000002_gene3590 2e-95 294.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,1KJ21@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_115606_1 690597.JH730959_gene2232 5.65e-55 201.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YNX6@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q AMP-binding enzyme C-terminal domain - - - ko:K15660 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_154520_1 930166.CD58_11785 1.45e-64 211.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_83348_1 96561.Dole_0553 3.32e-06 55.1 COG1716@1|root,COG1716@2|Bacteria 2|Bacteria T histone H2A K63-linked ubiquitination - - - - - - - - - - - - FHA k59_193320_2 985665.HPL003_19840 2.91e-46 162.0 COG3208@1|root,COG3208@2|Bacteria,1V5K3@1239|Firmicutes,4HJDQ@91061|Bacilli,276KD@186822|Paenibacillaceae 91061|Bacilli Q Thioesterase domain - - - - - - - - - - - - Thioesterase k59_115608_1 1415630.U771_27235 1.72e-40 142.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Fe-S oxidoreductase lutA - - ko:K18928 - - - - ko00000 - - - CCG k59_115608_2 269796.Rru_A1412 2.02e-18 85.9 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,2JQBE@204441|Rhodospirillales 204441|Rhodospirillales C LUD domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_129580_1 927677.ALVU02000001_gene4197 2.62e-05 45.8 COG0500@1|root,COG2226@2|Bacteria,1G5DI@1117|Cyanobacteria 1117|Cyanobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_25,Ubie_methyltran k59_12324_1 1114970.PSF113_0178 9.52e-10 63.5 COG0784@1|root,COG1639@1|root,COG0784@2|Bacteria,COG1639@2|Bacteria,1QR40@1224|Proteobacteria,1RTXG@1236|Gammaproteobacteria,1YMFK@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD,Response_reg k59_51038_1 159450.NH14_03360 6.72e-40 149.0 COG1457@1|root,COG1457@2|Bacteria,1PYF6@1224|Proteobacteria,2VI1F@28216|Betaproteobacteria,1K3TB@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the purine-cytosine permease (2.A.39) family cytX - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur k59_71164_2 998674.ATTE01000001_gene4300 1.57e-63 197.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,460T4@72273|Thiotrichales 72273|Thiotrichales J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_115878_1 1049564.TevJSym_al00290 2.2e-101 300.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1J4UX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_109719_1 1049564.TevJSym_aw00480 1.8e-93 279.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1J5PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_109719_2 1049564.TevJSym_aw00470 2.69e-58 182.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,1S47I@1236|Gammaproteobacteria,1J5Y5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0784 FOG CheY-like receiver cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_18317_1 570967.JMLV01000011_gene3248 1.29e-66 208.0 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUNB@28211|Alphaproteobacteria,2JQY6@204441|Rhodospirillales 204441|Rhodospirillales Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_193573_1 706587.Desti_0964 4.24e-114 360.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_5068_1 933262.AXAM01000050_gene3474 3.47e-102 313.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MHZQ@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_102609_2 1231190.NA8A_03315 3.69e-72 228.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TSCF@28211|Alphaproteobacteria,43HIY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_206441_1 673860.AciM339_1083 1.26e-53 179.0 COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,3F2KC@33867|unclassified Euryarchaeota 28890|Euryarchaeota J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_193574_2 84531.JMTZ01000094_gene641 1.33e-131 385.0 COG0079@1|root,COG0079@2|Bacteria,1MXDP@1224|Proteobacteria,1RR2V@1236|Gammaproteobacteria,1X4YJ@135614|Xanthomonadales 135614|Xanthomonadales E decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin cobC - - ko:K02225 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002 - - - Aminotran_1_2 k59_18321_1 335543.Sfum_1942 1.11e-76 249.0 COG0377@1|root,COG0649@1|root,COG0852@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2MR1T@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoBCD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,Oxidored_q6 k59_141737_1 1174504.AJTN02000258_gene1578 4.09e-07 52.0 COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HD08@91061|Bacilli,1ZPZV@1386|Bacillus 91061|Bacilli C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_141737_2 426114.THI_2496 2.38e-07 55.5 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,1KIWC@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_154764_1 335543.Sfum_1683 7.7e-113 335.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MR0M@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK-2 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - iAF987.Gmet_1825 AMP-binding,AMP-binding_C_2 k59_206448_1 1232410.KI421424_gene1649 5.6e-17 79.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,43TTD@69541|Desulfuromonadales 28221|Deltaproteobacteria L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_38741_2 203122.Sde_1650 0.0 959.0 COG5297@1|root,COG5297@2|Bacteria,1NRKN@1224|Proteobacteria,1S094@1236|Gammaproteobacteria,46A47@72275|Alteromonadaceae 1236|Gammaproteobacteria G CBD_II rgl11A - - - - - - - - - - - CBM_2 k59_206451_1 335543.Sfum_1977 1.53e-88 286.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_187912_1 314278.NB231_12259 1.15e-90 293.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWNH@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_173851_1 1457250.BBMO01000001_gene1581 1.16e-18 91.3 COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota 28890|Euryarchaeota P PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,PKD,Pilin_N,SdrD_B k59_51353_1 1049564.TevJSym_aa00960 1.35e-80 272.0 COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_135661_1 1049564.TevJSym_ao00720 3.49e-121 365.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1J4EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_199806_1 933262.AXAM01000067_gene855 5.45e-50 177.0 2A7N3@1|root,30WK3@2|Bacteria,1NERD@1224|Proteobacteria,42P7M@68525|delta/epsilon subdivisions,2WJTH@28221|Deltaproteobacteria,2MIHK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_115901_1 553385.JEMF01000008_gene1928 9.98e-14 77.8 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1XIKY@135619|Oceanospirillales 135619|Oceanospirillales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_180875_1 696281.Desru_2695 3.5e-38 142.0 COG1150@1|root,COG1150@2|Bacteria 2|Bacteria C 4Fe-4S dicluster domain - - 1.17.1.9 ko:K00125,ko:K03646 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000,ko02000 2.C.1.2 - - Fer4,Fer4_17,Fer4_8,FrhB_FdhB_C k59_25599_1 1304275.C41B8_12330 5.28e-22 94.4 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Preprotein translocase, subunit SecG secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_5095_4 1227739.Hsw_0699 2.67e-09 57.4 COG0465@1|root,COG0465@2|Bacteria,4PKMT@976|Bacteroidetes,47N5V@768503|Cytophagia 976|Bacteroidetes O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,TPR_19 k59_18340_1 1144343.PMI41_03108 1.57e-35 134.0 COG0477@1|root,COG0477@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily ycaD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08219 - - - - ko00000,ko02000 2.A.1.26 - - MFS_1,Sugar_tr k59_18340_3 1201290.M902_0897 2.23e-50 170.0 COG1899@1|root,COG1899@2|Bacteria,1R3SU@1224|Proteobacteria,42P29@68525|delta/epsilon subdivisions,2MSPV@213481|Bdellovibrionales,2WK0N@28221|Deltaproteobacteria 213481|Bdellovibrionales O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_135665_2 391615.ABSJ01000050_gene1170 9.13e-36 137.0 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1SASH@1236|Gammaproteobacteria,1JAPT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretion system (T2SS), protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_64425_3 1049564.TevJSym_ba00330 2.57e-72 226.0 2DB6R@1|root,2Z7I2@2|Bacteria,1R7AG@1224|Proteobacteria,1RQ0D@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_76763_2 519989.ECTPHS_13193 9.21e-74 231.0 COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1WXQ1@135613|Chromatiales 135613|Chromatiales S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_109754_1 765911.Thivi_2297 1.37e-84 272.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Rhs Element Vgr Protein - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD k59_5097_1 1120792.JAFV01000001_gene1940 2.41e-52 175.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,36YIS@31993|Methylocystaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_64429_1 237368.SCABRO_01637 1.12e-84 271.0 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_206484_1 1499967.BAYZ01000009_gene5394 1.38e-139 413.0 COG2766@1|root,COG2766@2|Bacteria 2|Bacteria T protein kinase activity prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_173871_1 670307.HYPDE_34018 8.28e-14 70.1 COG0824@1|root,COG0824@2|Bacteria,1RCSP@1224|Proteobacteria,2U6RM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_2 k59_64433_1 1232437.KL662002_gene4682 5.37e-38 147.0 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WIVN@28221|Deltaproteobacteria,2MIVP@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_25606_1 1288494.EBAPG3_9990 3.65e-17 78.6 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,372VZ@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Integrase, catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve_3 k59_25606_2 522772.Dacet_1482 2.15e-40 135.0 COG2963@1|root,COG2963@2|Bacteria,2GGNA@200930|Deferribacteres 200930|Deferribacteres L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_141761_1 667014.Thein_0927 9.99e-136 406.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2GHHW@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Transglycosylase SLT domain - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_167652_1 316067.Geob_3320 8.15e-127 374.0 COG1379@1|root,COG1379@2|Bacteria,1QYWZ@1224|Proteobacteria,43CDU@68525|delta/epsilon subdivisions,2X7PS@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_206495_1 933262.AXAM01000040_gene1210 5.47e-73 233.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2MIZ6@213118|Desulfobacterales 28221|Deltaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_12502_1 1049564.TevJSym_al00490 7.49e-131 402.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1J5F4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S internalization-related competence protein ComEC Rec2 ycaI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_141763_1 498211.CJA_2367 4.68e-50 180.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1FFTR@10|Cellvibrio 1236|Gammaproteobacteria L Oligonucleotide/oligosaccharide-binding (OB)-fold hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_141763_2 1049564.TevJSym_bl00090 6.74e-158 454.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_31630_1 335543.Sfum_0985 1.21e-26 100.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2MQQT@213462|Syntrophobacterales 28221|Deltaproteobacteria L HNH endonuclease - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH_5 k59_12506_1 1286106.MPL1_05374 2.91e-94 290.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_38787_1 198628.Dda3937_00243 7.29e-63 204.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,2JBQH@204037|Dickeya 1236|Gammaproteobacteria F Belongs to the GARS family purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729 GARS_A,GARS_C,GARS_N k59_187945_1 177439.DP2822 2.11e-28 118.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_187945_2 439235.Dalk_0920 7.82e-14 68.2 29GM5@1|root,303IT@2|Bacteria,1RG3T@1224|Proteobacteria,42RUX@68525|delta/epsilon subdivisions,2WNMJ@28221|Deltaproteobacteria,2MJY1@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_31631_1 105559.Nwat_0302 9.85e-47 159.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales 135613|Chromatiales Q PFAM ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_47895_1 1232410.KI421422_gene2007 9.49e-16 78.2 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,43S1A@69541|Desulfuromonadales 28221|Deltaproteobacteria U MotA/TolQ/ExbB proton channel family aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_190622_1 439235.Dalk_0683 1.69e-180 506.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria,2MJ08@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM dihydropteroate synthase DHPS - - 2.1.1.258 ko:K15023 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R02289,R10243 RC00004,RC00113,RC01144,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_80550_1 1121405.dsmv_0092 3.32e-20 95.9 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2MIXG@213118|Desulfobacterales 28221|Deltaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_67335_1 1122194.AUHU01000002_gene2839 4.31e-84 277.0 COG1196@1|root,COG1196@2|Bacteria,1QUTY@1224|Proteobacteria,1T351@1236|Gammaproteobacteria,46DBK@72275|Alteromonadaceae 1236|Gammaproteobacteria D Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - AAA_29,SbcCD_C k59_132507_2 1232410.KI421425_gene1547 9.6e-36 125.0 2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria,433CK@68525|delta/epsilon subdivisions,2WXC2@28221|Deltaproteobacteria,43VWA@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_132507_3 1232410.KI421425_gene1548 1.37e-56 181.0 COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria,42ZHG@68525|delta/epsilon subdivisions,2WV2W@28221|Deltaproteobacteria,43UR6@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_151785_1 933262.AXAM01000090_gene2614 1.51e-92 281.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42P0R@68525|delta/epsilon subdivisions,2WIKC@28221|Deltaproteobacteria,2MIC3@213118|Desulfobacterales 28221|Deltaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_126048_1 338966.Ppro_3077 1.48e-35 135.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,43U4T@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines nifR3 - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_73574_2 96561.Dole_0847 1.36e-43 159.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2MHKU@213118|Desulfobacterales 28221|Deltaproteobacteria G Alpha amylase, C-terminal all-beta domain glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_177760_1 2340.JV46_13550 6.54e-40 133.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,1J6YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF4212 k59_177760_2 765912.Thimo_1294 0.0 911.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1WW58@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_2195_1 497321.C664_17697 6.74e-38 136.0 COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2VMWX@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_2195_2 375286.mma_3672 1.01e-06 52.4 COG0477@1|root,COG2814@2|Bacteria,1QV32@1224|Proteobacteria,2VK3Z@28216|Betaproteobacteria,4732S@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Major facilitator superfamily yhjX - - - - - - - - - - - MFS_1 k59_93670_2 1123401.JHYQ01000012_gene2930 1.88e-51 172.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1S3NG@1236|Gammaproteobacteria,460PS@72273|Thiotrichales 72273|Thiotrichales S PFAM Copper chaperone SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_93670_3 1517681.HW45_26865 2.97e-12 67.8 COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1XVQP@135623|Vibrionales 135623|Vibrionales S membrane protein domain VP2641 - - - - - - - - - - - RDD k59_41881_1 398578.Daci_4444 4.99e-136 390.0 COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2VIRJ@28216|Betaproteobacteria,4AAC0@80864|Comamonadaceae 28216|Betaproteobacteria S Oxidoreductase ligC - 1.1.1.312 ko:K10219 ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220 M00533 R04278,R04279,R04418,R04419 RC00251,RC00254 ko00000,ko00001,ko00002,ko01000 - - - ADH_zinc_N,GFO_IDH_MocA k59_196662_1 1121405.dsmv_0625 1.69e-10 60.5 2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42SPB@68525|delta/epsilon subdivisions,2WPJK@28221|Deltaproteobacteria,2MKD1@213118|Desulfobacterales 28221|Deltaproteobacteria S Type I restriction enzyme R protein N terminus (HSDR_N) - - - - - - - - - - - - HSDR_N_2 k59_196662_2 411467.BACCAP_00355 3.06e-17 83.6 COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,2694K@186813|unclassified Clostridiales 186801|Clostridia FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_67338_1 195250.CM001776_gene949 3.77e-142 435.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_145365_1 335543.Sfum_1173 5.78e-99 315.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_6,Pyr_redox_2 k59_93674_1 223184.AS25_02810 6.42e-40 147.0 COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,1W875@1268|Micrococcaceae 201174|Actinobacteria P Cation transport protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_28507_1 1357279.N018_18165 2.62e-21 91.7 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1Z502@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 ko:K02517,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - iEC042_1314.EC042_2597,iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068 Lip_A_acyltrans k59_60949_1 335543.Sfum_0090 3.13e-55 188.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_C7,Cytochrome_cB k59_151791_2 335543.Sfum_2408 5.81e-71 223.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_80557_1 765912.Thimo_2844 6.42e-51 164.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1WZ44@135613|Chromatiales 135613|Chromatiales J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_80557_2 187272.Mlg_0473 7.86e-80 241.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1WXV2@135613|Chromatiales 135613|Chromatiales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_80557_3 1123518.ARWI01000001_gene1024 5.67e-41 138.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,460S8@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_9125_1 946483.Cenrod_2340 3.47e-101 310.0 COG3039@1|root,COG3039@2|Bacteria,1R64B@1224|Proteobacteria,2W09R@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_93675_1 1454004.AW11_02264 1.21e-27 114.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2W02U@28216|Betaproteobacteria 28216|Betaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_164511_2 1116472.MGMO_6c00190 1.34e-16 80.9 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1XFKE@135618|Methylococcales 135618|Methylococcales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_112805_1 933262.AXAM01000057_gene1536 6.78e-86 263.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MIG1@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_151792_1 1049564.TevJSym_ah00530 7.83e-14 70.1 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1JBYM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Binding-protein-dependent transport system inner membrane component dppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_151792_2 1294143.H681_24555 6.39e-18 83.6 COG4104@1|root,COG4253@1|root,COG4104@2|Bacteria,COG4253@2|Bacteria,1RGBB@1224|Proteobacteria,1S5JQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PAAR motif - - - - - - - - - - - - PAAR_motif k59_190640_1 1125700.HMPREF9195_02283 7.49e-30 121.0 COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes 203691|Spirochaetes H TIGRFAM folylpolyglutamate synthase dihydrofolate synthase folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_9128_1 1121106.JQKB01000097_gene2806 3.44e-73 241.0 COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,2JR4T@204441|Rhodospirillales 204441|Rhodospirillales L Resolvase, N terminal domain - - - - - - - - - - - - Recombinase,Resolvase k59_164512_1 1123502.AQXD01000003_gene1415 4.81e-10 62.4 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1X40P@135614|Xanthomonadales 135614|Xanthomonadales M murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_138411_1 398767.Glov_3698 5.68e-264 749.0 COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,42YHN@68525|delta/epsilon subdivisions,2WTYP@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase Tn3 family protein - - - - - - - - - - - - DDE_Tnp_Tn3,DUF4158 k59_28513_1 706587.Desti_0693 3.72e-35 134.0 COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MR0N@213462|Syntrophobacterales 28221|Deltaproteobacteria C ferredoxin oxidoreductase beta subunit korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_203509_1 880072.Desac_2166 2.15e-75 244.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria,2MRG4@213462|Syntrophobacterales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, N-terminal TPP binding domain porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_151794_1 1049564.TevJSym_bd00130 1.14e-98 295.0 COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria 1236|Gammaproteobacteria CF catalyzes the conversion of - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_112807_1 83406.HDN1F_23070 8.24e-23 98.2 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1J5DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_119753_1 1121456.ATVA01000011_gene1737 3.06e-11 63.2 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,42N2K@68525|delta/epsilon subdivisions,2WJ5D@28221|Deltaproteobacteria,2M8TA@213115|Desulfovibrionales 28221|Deltaproteobacteria S FAD dependent oxidoreductase - - - ko:K07137 - - - - ko00000 - - - DAO,FAD_binding_2,GIDA,HI0933_like,Pyr_redox_2 k59_48047_1 1122169.AREN01000001_gene942 4e-40 141.0 COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S2MK@1236|Gammaproteobacteria,1JD0U@118969|Legionellales 118969|Legionellales F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_126284_1 485913.Krac_3558 2.2e-109 340.0 COG4467@1|root,COG4467@2|Bacteria,2G8CX@200795|Chloroflexi 200795|Chloroflexi S PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66 k59_2314_3 670307.HYPDE_27868 3.56e-97 295.0 COG3315@1|root,COG3315@2|Bacteria,1RG18@1224|Proteobacteria,2VFMW@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM k59_42062_1 472759.Nhal_0222 5.76e-12 66.2 COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales 135613|Chromatiales T PFAM EAL domain - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_42062_2 713586.KB900536_gene925 5.48e-72 224.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_28611_2 1026882.MAMP_01526 0.000401 42.0 COG1665@1|root,COG1665@2|Bacteria,1RCBC@1224|Proteobacteria,1S28R@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - ko:K09717 - - - - ko00000 - - - NTP_transf_2 k59_9280_1 220664.PFL_2776 1.8e-64 203.0 2E9HZ@1|root,333R0@2|Bacteria,1P0AQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_99603_1 71139.XP_010054871.1 1.21e-05 52.8 COG2801@1|root,KOG0017@2759|Eukaryota,37R6P@33090|Viridiplantae 33090|Viridiplantae E Uncharacterized protein K02A2.6-like - - - ko:K07478 - - - - ko00000 - - - G-patch,RVT_1,RVT_3,Retrotrans_gag,rve k59_67553_3 857087.Metme_2393 2.33e-46 158.0 2BYAF@1|root,2ZWH8@2|Bacteria,1RBZ8@1224|Proteobacteria,1S3VD@1236|Gammaproteobacteria,1XDNJ@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF3581) - - - - - - - - - - - - DUF3581 k59_184572_2 1049564.TevJSym_ah00810 3.47e-99 302.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1J6SG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG0760 Parvulin-like peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_67554_2 484770.UFO1_2443 8.54e-20 84.0 2E4R2@1|root,32ZJM@2|Bacteria,1W5T1@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_177913_1 694431.DESACE_01260 9.51e-77 245.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2M6DK@213113|Desulfurellales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_61164_1 640081.Dsui_2415 2.14e-09 58.2 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,2KU7T@206389|Rhodocyclales 206389|Rhodocyclales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_61164_2 1122603.ATVI01000006_gene572 3e-76 235.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1X623@135614|Xanthomonadales 135614|Xanthomonadales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_164643_1 1304885.AUEY01000032_gene2019 3.97e-11 63.5 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42YZ2@68525|delta/epsilon subdivisions,2WTQ1@28221|Deltaproteobacteria,2MPM0@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02668,ko:K07709 ko02020,map02020 M00499,M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_9,sCache_3_2 k59_164643_2 56780.SYN_02214 2.98e-198 562.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_112958_1 572477.Alvin_2048 9.53e-107 318.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales 135613|Chromatiales I Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_73709_1 610130.Closa_3198 1.72e-05 53.1 COG3290@1|root,COG3437@1|root,COG3290@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,25GFW@186801|Clostridia,220KD@1506553|Lachnoclostridium 186801|Clostridia T HD domain - - - - - - - - - - - - GGDEF,HD,PAS_4,PAS_9 k59_132702_1 913865.DOT_2772 2.63e-14 68.9 COG3668@1|root,COG3668@2|Bacteria,1VHZU@1239|Firmicutes,2549A@186801|Clostridia 186801|Clostridia S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_132702_2 1122947.FR7_0534 9.13e-16 70.9 2DRAI@1|root,33AYP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_132702_3 1502770.JQMG01000001_gene1339 2.61e-21 94.4 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2VW9J@28216|Betaproteobacteria 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_119771_1 1150469.RSPPHO_00086 2.35e-37 142.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,2JQ58@204441|Rhodospirillales 204441|Rhodospirillales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_160599_1 649638.Trad_0369 4.99e-21 85.5 COG0759@1|root,COG0759@2|Bacteria,1WKD2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_160599_2 690850.Desaf_1411 4.9e-14 72.8 COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42VBC@68525|delta/epsilon subdivisions,2WRF0@28221|Deltaproteobacteria,2MD4U@213115|Desulfovibrionales 28221|Deltaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_37577_2 1220534.B655_1871 1.19e-09 58.5 COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23NQ3@183925|Methanobacteria 183925|Methanobacteria S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_192743_2 1049564.TevJSym_ax00480 1.83e-130 389.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria,1JBUB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_153752_1 882.DVU_0126 3.26e-15 75.1 COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria,2MA8B@213115|Desulfovibrionales 28221|Deltaproteobacteria V pfam abc - - - ko:K01990,ko:K01992,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC2_membrane_3,ABC_tran k59_153752_2 1121396.KB893001_gene3965 2.37e-100 310.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MPNG@213118|Desulfobacterales 28221|Deltaproteobacteria G AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_56086_1 1125863.JAFN01000001_gene163 1.51e-86 273.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_70106_1 279238.Saro_2809 7.69e-13 71.2 COG3670@1|root,COG3670@2|Bacteria 2|Bacteria Q oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_70106_2 1238450.VIBNISOn1_910007 9.71e-11 69.7 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1RS6U@1236|Gammaproteobacteria,1XV73@135623|Vibrionales 135623|Vibrionales K COG0583 Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_96480_1 1123399.AQVE01000009_gene3086 6.17e-06 47.8 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,460ZA@72273|Thiotrichales 72273|Thiotrichales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_96480_2 519989.ECTPHS_00085 2.2e-27 105.0 2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_96480_3 1049564.TevJSym_ax00280 1.15e-68 220.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1J4QH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Permease perM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_63494_1 1111454.HMPREF1250_1118 9.47e-19 84.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,4H22M@909932|Negativicutes 909932|Negativicutes D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_63494_2 56780.SYN_01010 1.97e-24 104.0 COG1538@1|root,COG1538@2|Bacteria,1PTZ6@1224|Proteobacteria,42RK2@68525|delta/epsilon subdivisions,2WNMB@28221|Deltaproteobacteria,2MS0Y@213462|Syntrophobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_17274_2 1224136.AMFN01000024_gene54 0.000324 48.1 COG3617@1|root,COG3617@2|Bacteria,1N09A@1224|Proteobacteria,1S9DY@1236|Gammaproteobacteria,283HG@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria K BRO family, N-terminal domain - - - - - - - - - - - - Bro-N k59_17274_4 1049564.TevJSym_ae00030 2e-64 220.0 COG0358@1|root,COG0358@2|Bacteria,1MWQW@1224|Proteobacteria 1224|Proteobacteria L Toprim domain - - - - - - - - - - - - Toprim_3 k59_70108_1 177437.HRM2_23410 2.55e-12 65.1 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MHV0@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_11552_1 243231.GSU0771 4.51e-108 322.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,42MXJ@68525|delta/epsilon subdivisions,2WKAC@28221|Deltaproteobacteria,43S6E@69541|Desulfuromonadales 28221|Deltaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_24560_1 335543.Sfum_1817 2.4e-13 70.9 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MRH3@213462|Syntrophobacterales 28221|Deltaproteobacteria S ABC1 family - - - ko:K03688 - - - - ko00000 - - - ABC1,RIO1 k59_24560_2 498761.HM1_0560 2.18e-10 66.6 COG2199@1|root,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,249J7@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - GGDEF,PAS_9,Response_reg k59_122330_1 177437.HRM2_12670 2.15e-53 184.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria,2MIES@213118|Desulfobacterales 28221|Deltaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_50261_1 1049564.TevJSym_ac01090 2.27e-67 213.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1J4P1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00132,iE2348C_1286.E2348C_0137,iECBD_1354.ECBD_3485,iECB_1328.ECB_00133,iECD_1391.ECD_00133,iPC815.YPO3401 Pantoate_transf k59_50261_3 83406.HDN1F_20020 7.89e-21 87.8 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1J6J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131 HPPK k59_70112_1 65393.PCC7424_5216 7.6e-93 280.0 COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria,3KH7H@43988|Cyanothece 1117|Cyanobacteria C Alcohol dehydrogenase GroES domain protein - - - ko:K12957 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_134650_1 335543.Sfum_1004 1.55e-78 240.0 COG1136@1|root,COG1136@2|Bacteria,1QU8Q@1224|Proteobacteria,42SGV@68525|delta/epsilon subdivisions,2WPBY@28221|Deltaproteobacteria,2MRRK@213462|Syntrophobacterales 28221|Deltaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_17279_1 1365176.N186_04310 4.81e-53 188.0 COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota 28889|Crenarchaeota G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_4223_1 1121405.dsmv_3769 6.19e-83 254.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MIHH@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_70116_1 400668.Mmwyl1_4390 3.73e-31 122.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales 135619|Oceanospirillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_70116_2 768671.ThimaDRAFT_2385 5.98e-19 81.3 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_101685_1 1097668.BYI23_B008700 7.31e-07 49.3 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,1K8QI@119060|Burkholderiaceae 28216|Betaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like k59_101685_2 399739.Pmen_4403 3.42e-27 99.4 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1YH0P@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Rubredoxin rubA - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Rubredoxin k59_101685_3 1049564.TevJSym_at00550 6.29e-102 305.0 COG3217@1|root,COG3217@2|Bacteria,1MXN2@1224|Proteobacteria,1RMN7@1236|Gammaproteobacteria,1J69D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Fe-S protein ycbX GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0050896,GO:0098754 - ko:K07140 - - - - ko00000 - - - FAD_binding_6,Fer2,MOSC,MOSC_N,NAD_binding_1 k59_101685_4 1049564.TevJSym_at00540 8e-65 207.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1J50S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, ATPase PilU uptC - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_89058_1 319224.Sputcn32_2653 1.12e-10 70.9 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,2Q900@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4115) rodZ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_122684_3 713586.KB900536_gene2673 1.48e-14 72.0 COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,1SDBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved hypothetical ATP binding protein - - - ko:K06945 - - - - ko00000 - - - ATP_bind_1,Ras k59_11883_1 263820.PTO0618 6.35e-71 229.0 COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,241M7@183967|Thermoplasmata 183967|Thermoplasmata O ATP-dependent peptidase activity - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Mg_chelatase,Sigma54_activat k59_37892_1 1307759.JOMJ01000003_gene1692 1.95e-46 164.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBF@1224|Proteobacteria,42RAR@68525|delta/epsilon subdivisions,2WN52@28221|Deltaproteobacteria,2MAC7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - GAF,GAF_2,SpoIIE k59_173110_1 771875.Ferpe_0985 1.44e-159 463.0 COG2403@1|root,COG2403@2|Bacteria,2GCJ5@200918|Thermotogae 200918|Thermotogae S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - k59_89289_1 933262.AXAM01000079_gene2201 1.42e-70 238.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MIYJ@213118|Desulfobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_166935_1 589873.EP13_12490 1.25e-73 236.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,464DX@72275|Alteromonadaceae 1236|Gammaproteobacteria S NAD FAD-binding protein - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_141063_1 1380390.JIAT01000011_gene2319 1.9e-49 176.0 COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4CPPW@84995|Rubrobacteria 84995|Rubrobacteria P sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_37894_1 880072.Desac_0544 3.74e-83 276.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_141064_1 265072.Mfla_1055 5.45e-21 92.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KM7W@206350|Nitrosomonadales 206350|Nitrosomonadales T Sigma-54 interaction domain - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_56304_1 573061.Clocel_1867 7.71e-50 172.0 COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,36ED0@31979|Clostridiaceae 186801|Clostridia S tigr00255 yicC - - - - - - - - - - - DUF1732,YicC_N k59_134904_1 686340.Metal_3681 2.09e-132 425.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1XDJX@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_89292_1 1479235.KK366039_gene445 3.06e-07 57.4 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1XN4U@135619|Oceanospirillales 135619|Oceanospirillales CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit - - - ko:K05565 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,Proton_antipo_M,Proton_antipo_N k59_122695_1 335543.Sfum_1179 7.74e-132 391.0 COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales 28221|Deltaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 k59_56305_1 1255043.TVNIR_2794 1.25e-31 122.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales 135613|Chromatiales G PFAM Alpha amylase, catalytic - - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_56305_2 857087.Metme_0593 2.03e-104 312.0 COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1XE9X@135618|Methylococcales 135618|Methylococcales G PFAM Carbohydrate purine kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_24865_1 1049564.TevJSym_af00620 3.98e-113 341.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1J4UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_141066_3 748247.AZKH_1522 3.57e-06 49.3 COG1538@1|root,COG1538@2|Bacteria,1MUZZ@1224|Proteobacteria,2VH6M@28216|Betaproteobacteria,2KW8S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_141066_5 375286.mma_1013 7.18e-42 152.0 COG0641@1|root,COG0641@2|Bacteria,1NG2E@1224|Proteobacteria,2VMIE@28216|Betaproteobacteria 28216|Betaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_192943_1 1286106.MPL1_12331 8.19e-47 168.0 COG0553@1|root,COG1502@1|root,COG0553@2|Bacteria,COG1502@2|Bacteria,1MX6H@1224|Proteobacteria,1RY96@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL helicase - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_192943_2 290512.Paes_1056 0.0 1876.0 COG0610@1|root,COG1205@1|root,COG0610@2|Bacteria,COG1205@2|Bacteria 2|Bacteria L dead DEAH box helicase Z012_07420 - 3.1.21.3,3.1.21.5 ko:K01153,ko:K01156 - - - - ko00000,ko01000,ko02048 - - - DEAD,Helicase_C,ResIII,Z1 k59_192943_3 290512.Paes_1057 0.0 1101.0 28HBW@1|root,2Z7NV@2|Bacteria,1FFAK@1090|Chlorobi 1090|Chlorobi S Domain of unknown function (DUF1998) - - - - - - - - - - - - - k59_192943_4 290512.Paes_1058 7.7e-246 679.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity - - 3.4.21.88 ko:K01356,ko:K19676 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03036,ko03400 - - - AAA_19,HSDR_N_2,Peptidase_S24,UvrD-helicase,UvrD_C,UvrD_C_2 k59_192943_5 290512.Paes_1059 1.42e-159 473.0 28P3Z@1|root,2ZBZA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_192943_6 290512.Paes_1060 1.29e-295 816.0 COG0507@1|root,COG0507@2|Bacteria,1FFI9@1090|Chlorobi 1090|Chlorobi L PFAM NERD domain protein - - - - - - - - - - - - NERD,UvrD_C_2 k59_192943_7 331869.BAL199_13608 1.51e-06 48.1 COG3311@1|root,COG3311@2|Bacteria,1N9IM@1224|Proteobacteria,2UH9G@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_17 k59_205855_4 395495.Lcho_1138 2.11e-110 336.0 COG1018@1|root,COG1018@2|Bacteria,1MV41@1224|Proteobacteria,2VIIV@28216|Betaproteobacteria,1KK8D@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress hmp - 1.14.12.17 ko:K05916,ko:K07006,ko:K21832 ko05132,map05132 - - - ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,Globin,NAD_binding_1 k59_115203_1 639283.Snov_3768 3.84e-42 157.0 COG0438@1|root,COG0438@2|Bacteria,1QXMF@1224|Proteobacteria 1224|Proteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Sulfotransfer_2 k59_4494_5 243233.MCA0577 2.57e-37 130.0 COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales 135618|Methylococcales G Cupin domain - - - - - - - - - - - - Cupin_2 k59_37914_1 1387312.BAUS01000012_gene2152 8.63e-62 204.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,2KKWV@206350|Nitrosomonadales 206350|Nitrosomonadales S Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_50549_1 396588.Tgr7_1236 6.94e-117 345.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_50549_2 631362.Thi970DRAFT_02308 8.89e-75 227.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_50549_3 1049564.TevJSym_av00470 2.17e-162 467.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1J4M8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_50549_4 580332.Slit_2117 4.05e-90 278.0 COG0475@1|root,COG0475@2|Bacteria,1PK6U@1224|Proteobacteria,2WAEY@28216|Betaproteobacteria,44WJS@713636|Nitrosomonadales 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_199082_1 690850.Desaf_0757 2.04e-28 117.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M2X@68525|delta/epsilon subdivisions,2WJMY@28221|Deltaproteobacteria,2M8ZP@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_24868_1 1049564.TevJSym_ba00080 1.24e-11 65.9 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1J4TE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_24868_2 1249627.D779_1894 2.6e-55 177.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1WWV2@135613|Chromatiales 135613|Chromatiales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_166954_1 96561.Dole_1228 9.14e-62 195.0 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42RPD@68525|delta/epsilon subdivisions,2WNI0@28221|Deltaproteobacteria,2MK1B@213118|Desulfobacterales 28221|Deltaproteobacteria H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_166954_2 555779.Dthio_PD1141 2.61e-61 194.0 COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions,2WQNM@28221|Deltaproteobacteria,2MBTN@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU k59_109120_1 1120956.JHZK01000036_gene1915 4.59e-41 147.0 COG0646@1|root,COG0646@2|Bacteria 2|Bacteria E methionine synthase metH - 2.1.1.13,2.1.1.5 ko:K00544,ko:K00548 ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R02821,R09365 RC00035,RC00113,RC00496,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_109120_2 335543.Sfum_0988 4.89e-08 53.1 COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,2MS1U@213462|Syntrophobacterales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_76015_1 1038922.PflQ2_4000 2.41e-50 174.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_166962_2 768671.ThimaDRAFT_0259 7.64e-59 184.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales 135613|Chromatiales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_166962_3 1286106.MPL1_09717 5.86e-16 69.7 COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,1SGC9@1236|Gammaproteobacteria,461DS@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 k59_125063_1 1116472.MGMO_76c00010 1.32e-121 393.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1XDJX@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_8215_2 1249627.D779_0060 5.35e-75 238.0 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales 135613|Chromatiales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_98736_1 448385.sce3998 1.15e-32 132.0 COG2114@1|root,COG2199@1|root,COG3266@1|root,COG2114@2|Bacteria,COG3266@2|Bacteria,COG3706@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2YZ76@29|Myxococcales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,Response_reg k59_21285_1 420324.KI911965_gene635 9.15e-65 206.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_3 k59_47088_2 765913.ThidrDRAFT_0590 4.07e-113 338.0 COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,1S2B3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,SBP_bac_3 k59_47088_3 28229.ND2E_4283 4.37e-06 51.2 COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,1RR15@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_125070_1 765911.Thivi_3320 4.3e-198 557.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1WVW3@135613|Chromatiales 135613|Chromatiales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_125070_2 395493.BegalDRAFT_0634 0.000645 40.8 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,460K9@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_105349_2 449447.MAE_44190 6.51e-29 109.0 COG3415@1|root,COG3415@2|Bacteria,1GA2F@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_72950_1 439235.Dalk_4831 1.08e-72 236.0 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_144529_1 1298860.AUEM01000002_gene421 6.62e-05 46.6 COG1388@1|root,COG1388@2|Bacteria,2I3X4@201174|Actinobacteria,4FMDC@85023|Microbacteriaceae 201174|Actinobacteria M Lysin motif - - - - - - - - - - - - LysM k59_144529_2 338963.Pcar_2311 2.71e-24 95.5 COG3357@1|root,COG3357@2|Bacteria,1N7JG@1224|Proteobacteria,42VEP@68525|delta/epsilon subdivisions,2WRD7@28221|Deltaproteobacteria,43VMA@69541|Desulfuromonadales 28221|Deltaproteobacteria K transcriptional regulator containing an HTH domain fused to a Zn-ribbon - - - ko:K07743 - - - - ko00000 - - - HTH_5 k59_8223_1 765913.ThidrDRAFT_1027 3.95e-101 306.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_157290_1 1049564.TevJSym_ac01220 1.25e-60 196.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1J95I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_157290_2 1049564.TevJSym_ac01210 3.2e-58 186.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1J6KR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_27677_1 1209072.ALBT01000047_gene458 2.42e-34 125.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1FH8N@10|Cellvibrio 1236|Gammaproteobacteria S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate kdsC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECO26_1355.ECO26_4302 Hydrolase_3 k59_79812_1 1348657.M622_03250 7.17e-80 241.0 28N0M@1|root,2ZB6Z@2|Bacteria,1Q4H5@1224|Proteobacteria,2VNA9@28216|Betaproteobacteria 28216|Betaproteobacteria S Toxin with endonuclease activity, of toxin-antitoxin system - - - ko:K19155 - - - - ko00000,ko01000,ko02048 - - - Toxin_YhaV k59_79812_2 102232.GLO73106DRAFT_00002460 1.11e-38 132.0 COG2002@1|root,COG2002@2|Bacteria,1G7VC@1117|Cyanobacteria 1117|Cyanobacteria K prlF antitoxin for toxin YhaV_toxin - - - ko:K19156 - - - - ko00000,ko02048 - - - PrlF_antitoxin k59_170513_1 706587.Desti_4457 7.4e-15 76.6 COG2020@1|root,COG2020@2|Bacteria,1N3YJ@1224|Proteobacteria,4309G@68525|delta/epsilon subdivisions,2WSN0@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_157292_1 335543.Sfum_1166 1.28e-94 287.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MQWC@213462|Syntrophobacterales 28221|Deltaproteobacteria C oxidoreductase, alpha subunit korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_195829_1 1122604.JONR01000086_gene1126 1.5e-49 164.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1X493@135614|Xanthomonadales 135614|Xanthomonadales P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_131620_1 1049564.TevJSym_ab01040 4.07e-113 351.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_144535_1 941449.dsx2_1486 1.49e-27 109.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2M994@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_144535_2 1121396.KB893084_gene406 4.62e-101 300.0 COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2MK7N@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_34212_1 266264.Rmet_5217 7.84e-103 310.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_176809_1 1125863.JAFN01000001_gene3444 5.96e-128 374.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42Q41@68525|delta/epsilon subdivisions,2WK4A@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_92632_1 1121451.DESAM_21269 9.23e-69 229.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2M91R@213115|Desulfovibrionales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_125080_1 880073.Calab_0497 2.05e-124 374.0 COG0465@1|root,COG0465@2|Bacteria,2NP22@2323|unclassified Bacteria 2|Bacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_66443_2 1397528.Q671_06955 6.58e-15 76.6 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1XI0Q@135619|Oceanospirillales 135619|Oceanospirillales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_202732_1 631454.N177_1110 4.03e-79 248.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,1JPQ3@119043|Rhodobiaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component MA20_30170 - - - - - - - - - - - DctM k59_202732_3 338969.Rfer_1844 1.32e-33 119.0 COG3052@1|root,COG3052@2|Bacteria,1N71C@1224|Proteobacteria,2WFW8@28216|Betaproteobacteria,4AF0W@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM malonate decarboxylase delta subunit - - - ko:K13931 - - - - ko00000,ko02000 3.B.1.1.4 - - ACP k59_202732_4 748247.AZKH_1588 9e-101 301.0 COG4799@1|root,COG4799@2|Bacteria,1PDNC@1224|Proteobacteria,2VIGW@28216|Betaproteobacteria,2KXS3@206389|Rhodocyclales 206389|Rhodocyclales I Carboxyl transferase domain - - 4.1.1.87 ko:K13932 - - - - ko00000,ko01000 - - - Carboxyl_trans k59_79819_1 709797.CSIRO_4235 5.71e-26 105.0 COG0863@1|root,COG0863@2|Bacteria,1R3SK@1224|Proteobacteria,2U1D7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Pfam:Methyltransf_26 - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_53495_1 1128912.GMES_4038 1.59e-10 60.8 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,464NI@72275|Alteromonadaceae 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b0114,iAF1260.b0114,iBWG_1329.BWG_0107,iE2348C_1286.E2348C_0117,iEC55989_1330.EC55989_0107,iECDH10B_1368.ECDH10B_0094,iECDH1ME8569_1439.ECDH1ME8569_0108,iECH74115_1262.ECH74115_0121,iECIAI1_1343.ECIAI1_0112,iECNA114_1301.ECNA114_0106,iECO103_1326.ECO103_0114,iECO111_1330.ECO111_0115,iECO26_1355.ECO26_0116,iECSE_1348.ECSE_0114,iECSF_1327.ECSF_0127,iECSP_1301.ECSP_0115,iECUMN_1333.ECUMN_0111,iECW_1372.ECW_m0111,iECs_1301.ECs0118,iEKO11_1354.EKO11_3802,iETEC_1333.ETEC_0110,iEcDH1_1363.EcDH1_3488,iEcE24377_1341.EcE24377A_0116,iEcHS_1320.EcHS_A0118,iEcSMS35_1347.EcSMS35_0124,iEcolC_1368.EcolC_3545,iG2583_1286.G2583_0118,iJO1366.b0114,iJR904.b0114,iUMNK88_1353.UMNK88_112,iWFL_1372.ECW_m0111,iY75_1357.Y75_RS00580,iZ_1308.Z0124 Transketolase_N k59_53495_2 395494.Galf_2871 5.47e-164 468.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,44V1G@713636|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_53495_3 398527.Bphyt_3568 6.25e-23 98.2 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K1I1@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_21310_2 1121921.KB898715_gene41 2.12e-28 104.0 COG3905@1|root,COG3905@2|Bacteria,1NHN3@1224|Proteobacteria,1SGV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Ribbon-helix-helix protein, copG family - - - - - - - - - - - - RHH_1 k59_21310_3 1121921.KB898715_gene42 1.8e-40 135.0 COG3668@1|root,COG3668@2|Bacteria 2|Bacteria D Plasmid stabilization system spsF - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_176818_1 1150469.RSPPHO_01254 5.09e-34 128.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,2JQ3X@204441|Rhodospirillales 204441|Rhodospirillales C oxidase, subunit cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_176818_2 550540.Fbal_2693 3.41e-12 60.1 COG4890@1|root,COG4890@2|Bacteria 2|Bacteria S oxidoreductase activity, acting on diphenols and related substances as donors ybgT GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019867,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0071944 1.10.3.14 ko:K00424 ko00190,ko02020,map00190,map02020 M00153 - - ko00000,ko00001,ko01000 3.D.4.3 - - YbgT_YccB k59_183488_2 584708.Apau_2390 5.35e-77 248.0 COG3437@1|root,COG3437@2|Bacteria,3TC32@508458|Synergistetes 508458|Synergistetes T response regulator receiver - - - - - - - - - - - - HD_5,Response_reg k59_27899_1 1144312.PMI09_05548 3.05e-46 174.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,4BCVF@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_8454_1 323261.Noc_2021 3.69e-83 271.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg k59_79968_1 1249627.D779_3360 4.5e-62 211.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_163972_1 159450.NH14_11955 4.81e-44 161.0 COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VIHY@28216|Betaproteobacteria,1K26P@119060|Burkholderiaceae 28216|Betaproteobacteria P Predicted Permease Membrane Region - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_41078_1 653733.Selin_1858 9.36e-138 425.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria 2|Bacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_98933_1 37659.JNLN01000001_gene2280 6.15e-39 142.0 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,36DFF@31979|Clostridiaceae 186801|Clostridia S domain protein nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_98933_2 933262.AXAM01000013_gene1322 8.23e-54 171.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria,2MKPU@213118|Desulfobacterales 28221|Deltaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_98933_3 933262.AXAM01000013_gene1323 8.24e-18 76.6 COG1550@1|root,COG1550@2|Bacteria,1N2H7@1224|Proteobacteria,42UCZ@68525|delta/epsilon subdivisions,2WR50@28221|Deltaproteobacteria,2MKM4@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_53672_1 1049564.TevJSym_ao00250 5.91e-149 431.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1J4I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_60322_1 156889.Mmc1_2204 9.75e-45 149.0 COG1633@1|root,COG1633@2|Bacteria,1RDK1@1224|Proteobacteria 1224|Proteobacteria S PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_60322_2 378806.STAUR_4257 7.04e-203 579.0 2DBCZ@1|root,2Z8GV@2|Bacteria,1QZIA@1224|Proteobacteria,43CJM@68525|delta/epsilon subdivisions,2WXM0@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_118897_1 292459.STH2279 3.53e-47 167.0 COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia 186801|Clostridia L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_66633_1 1278309.KB907101_gene345 7.04e-86 263.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,1XHK7@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_92926_1 999411.HMPREF1092_02452 1.93e-40 147.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,36DMV@31979|Clostridiaceae 186801|Clostridia O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_73076_1 1123228.AUIH01000091_gene569 5.4e-118 371.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_79971_1 1320556.AVBP01000011_gene3420 9.43e-30 127.0 COG3447@1|root,COG5001@1|root,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,43RVC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_7,PAS_9,dCache_1 k59_144790_1 518766.Rmar_0923 5.39e-24 100.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1FIM5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EI ArgK protein icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_144790_2 1121405.dsmv_0419 1.47e-67 211.0 COG1309@1|root,COG1309@2|Bacteria,1R4VA@1224|Proteobacteria,42PZX@68525|delta/epsilon subdivisions,2WK4I@28221|Deltaproteobacteria,2MI67@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N k59_125373_1 335543.Sfum_1576 7.18e-86 258.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MR0Z@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_105554_1 1123487.KB892837_gene3977 2.73e-18 91.3 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,MASE3,PAS,PAS_4,PAS_9,Phosphonate-bd k59_151187_2 748247.AZKH_1952 9.73e-96 289.0 COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2VJ9I@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_151187_3 1249627.D779_4053 1.4e-18 82.4 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales 135613|Chromatiales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_98937_1 1144275.COCOR_01063 5.83e-51 176.0 COG0596@1|root,COG0596@2|Bacteria,1QVBQ@1224|Proteobacteria 1224|Proteobacteria S Alpha beta hydrolase - - - - - - - - - - - - - k59_118905_1 335543.Sfum_1724 1.8e-123 366.0 COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJ17@28221|Deltaproteobacteria,2MRAB@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S double cluster binding domain - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_16,Glu_synthase k59_157521_1 335543.Sfum_1999 1.48e-136 404.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2MQTE@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1720_1 96561.Dole_0670 3.17e-101 311.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales 28221|Deltaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_14559_1 639282.DEFDS_1091 9.61e-13 67.0 COG0782@1|root,COG0782@2|Bacteria,2GFGG@200930|Deferribacteres 200930|Deferribacteres K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_151189_1 1121405.dsmv_1320 3.39e-103 325.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_60323_3 1049564.TevJSym_ac02050 2.31e-256 721.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1J4QZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_10318_1 96561.Dole_0660 4.75e-75 238.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_204555_2 283942.IL0529 4.03e-128 382.0 COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria,2QF1V@267893|Idiomarinaceae 1236|Gammaproteobacteria S AAA domain - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_146452_1 626523.GCWU000342_01858 1.38e-17 77.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia 186801|Clostridia L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_146452_2 211165.AJLN01000070_gene5505 0.000151 45.1 COG3437@1|root,COG3437@2|Bacteria,1G2ZH@1117|Cyanobacteria,1JH9Y@1189|Stigonemataceae 1117|Cyanobacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_23300_1 1205680.CAKO01000002_gene2222 1.14e-50 186.0 COG1409@1|root,COG1409@2|Bacteria,1R8W7@1224|Proteobacteria,2U64B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_23300_2 1183438.GKIL_2506 2.95e-08 58.5 COG0569@1|root,COG0569@2|Bacteria,1GR3U@1117|Cyanobacteria 1117|Cyanobacteria U Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_23300_3 1249627.D779_0584 2e-46 168.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_36355_1 509191.AEDB02000066_gene743 7.63e-52 180.0 COG0784@1|root,COG2206@1|root,COG0784@2|Bacteria,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,3WMYG@541000|Ruminococcaceae 186801|Clostridia T Domain of unknown function (DUF3369) - - - - - - - - - - - - DUF3369,GAF,GAF_2,HAMP,HD,HD_5,PAS_9,Response_reg k59_81712_1 997346.HMPREF9374_1497 2.02e-34 124.0 COG0204@1|root,COG0204@2|Bacteria,1UGYE@1239|Firmicutes,4HFMM@91061|Bacilli,27CMG@186824|Thermoactinomycetaceae 91061|Bacilli I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_81712_2 666681.M301_2183 8.97e-134 387.0 COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2VH1P@28216|Betaproteobacteria 28216|Betaproteobacteria S phosphatidate Cytidylyltransferase - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_120919_1 1265505.ATUG01000001_gene3518 1.77e-32 124.0 COG0189@1|root,COG0189@2|Bacteria,1MWQA@1224|Proteobacteria,43B1R@68525|delta/epsilon subdivisions,2X6FW@28221|Deltaproteobacteria,2MJ6I@213118|Desulfobacterales 28221|Deltaproteobacteria HJ RimK-like ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_159347_1 1049564.TevJSym_an00030 1.77e-101 310.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_95216_1 768671.ThimaDRAFT_4344 5.05e-34 127.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1X2CM@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_152681_1 296591.Bpro_5511 1.59e-29 107.0 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_28,HTH_29,HTH_32,LZ_Tnp_IS481 k59_152681_2 1463885.KL578497_gene2218 7.17e-22 93.6 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_32 k59_127616_1 748280.NH8B_0126 1.43e-53 180.0 COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria 28216|Betaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_17 k59_127616_2 314278.NB231_00840 2.12e-22 93.2 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_100557_1 1304885.AUEY01000037_gene2173 1.33e-07 54.3 COG1388@1|root,COG1388@2|Bacteria,1NIZ7@1224|Proteobacteria,42XXF@68525|delta/epsilon subdivisions,2WSUC@28221|Deltaproteobacteria,2MM6Q@213118|Desulfobacterales 28221|Deltaproteobacteria M Lysin motif - - - - - - - - - - - - LysM k59_165581_1 335543.Sfum_1147 1.32e-176 507.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MQT6@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 k59_23306_2 1049564.TevJSym_av00280 2.71e-72 221.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1J6D2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U general secretion pathway protein gspG GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_29571_1 1168065.DOK_08909 7.54e-35 129.0 COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,1S2CW@1236|Gammaproteobacteria,1J5X8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) ybfF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689 - ko:K01175 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_29571_2 1049564.TevJSym_af00350 6.85e-158 451.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1J8GR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_3191_2 713586.KB900536_gene786 2.68e-98 291.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales 135613|Chromatiales L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_3191_3 582744.Msip34_1005 2.82e-10 61.2 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,2KMD9@206350|Nitrosomonadales 206350|Nitrosomonadales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_16115_1 1121033.AUCF01000016_gene5532 3.91e-197 581.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,2JR80@204441|Rhodospirillales 204441|Rhodospirillales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_121127_1 1121405.dsmv_1320 7.58e-91 291.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_62509_2 589865.DaAHT2_0975 3.15e-27 108.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,42RIT@68525|delta/epsilon subdivisions,2WP64@28221|Deltaproteobacteria,2MJX0@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM peptidase M22 glycoprotease yeaZ - 2.3.1.234 ko:K01409,ko:K14742 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_100711_1 903814.ELI_3306 5.97e-76 256.0 COG0493@1|root,COG1034@1|root,COG3383@1|root,COG0493@2|Bacteria,COG1034@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,25UR0@186806|Eubacteriaceae 186801|Clostridia C NADPH-dependent glutamate synthase beta chain and related oxidoreductases - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3 k59_10496_1 1123393.KB891316_gene1481 8.46e-61 196.0 COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,2VRVY@28216|Betaproteobacteria,1KSWC@119069|Hydrogenophilales 119069|Hydrogenophilales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_107665_1 1499967.BAYZ01000028_gene1265 1.61e-113 338.0 COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_159533_1 335543.Sfum_1469 2.3e-74 232.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,2MRHZ@213462|Syntrophobacterales 28221|Deltaproteobacteria G Fructose-bisphosphate aldolase class-II fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_165726_1 1049564.TevJSym_au00160 3.22e-84 266.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_165726_3 316275.VSAL_I0719 2.61e-54 171.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1XXFW@135623|Vibrionales 135623|Vibrionales C Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system iscA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_165726_4 1195246.AGRI_14350 1.44e-41 139.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,466TH@72275|Alteromonadaceae 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters iscU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055 NifU_N k59_204710_1 596328.HMPREF0578_0721 3.52e-40 145.0 COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4D3TP@85005|Actinomycetales 201174|Actinobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_49287_1 1049564.TevJSym_ao00750 9.02e-199 554.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1077 Actin-like ATPase involved in cell morphogenesis mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_139642_1 713586.KB900536_gene795 2.88e-53 173.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1WX51@135613|Chromatiales 135613|Chromatiales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_139642_2 1049564.TevJSym_ac01370 1.04e-89 276.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1J4P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_139642_3 519989.ECTPHS_06157 5.58e-23 110.0 COG2199@1|root,COG3706@2|Bacteria,1R0PW@1224|Proteobacteria,1T4MZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_10500_1 580332.Slit_1220 4.62e-36 128.0 COG0664@1|root,COG0664@2|Bacteria,1RD80@1224|Proteobacteria,2VXU2@28216|Betaproteobacteria 28216|Betaproteobacteria T Cyclic nucleotide-monophosphate binding domain hoxI - - - - - - - - - - - cNMP_binding k59_197883_1 106648.BBLJ01000001_gene2199 2.02e-33 132.0 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,1RNRK@1236|Gammaproteobacteria,3NK7X@468|Moraxellaceae 1236|Gammaproteobacteria U Large exoproteins involved in heme utilization or adhesion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,PT-VENN k59_197883_3 1274524.BSONL12_10286 1.6e-28 114.0 COG3210@1|root,COG5444@1|root,COG3210@2|Bacteria,COG5444@2|Bacteria,1VH72@1239|Firmicutes,4HP45@91061|Bacilli 91061|Bacilli U nuclease activity alaRS - - ko:K21493 - - - - ko00000,ko01000,ko02048 - - - LXG,WXG100 k59_197883_5 491205.JARQ01000007_gene3068 6.63e-25 106.0 2EMFS@1|root,33F4H@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4280 k59_127791_1 519989.ECTPHS_11010 3.81e-07 51.2 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_127791_2 1049564.TevJSym_ac01860 3.72e-241 675.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,1J5F7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF k59_133706_1 1123368.AUIS01000006_gene595 5.42e-49 167.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,2NBUP@225057|Acidithiobacillales 225057|Acidithiobacillales O Tetratricopeptide repeat - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_139644_1 933262.AXAM01000061_gene1666 5.45e-99 313.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_55239_1 933262.AXAM01000060_gene2882 8.88e-52 166.0 COG2204@1|root,COG2204@2|Bacteria,1P58Q@1224|Proteobacteria,430GN@68525|delta/epsilon subdivisions,2WVMH@28221|Deltaproteobacteria,2MKSV@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_100713_2 2340.JV46_02640 3.17e-52 194.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1JB0I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_74756_1 1232410.KI421414_gene2924 4.46e-111 334.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,43RXM@69541|Desulfuromonadales 28221|Deltaproteobacteria S SpoVR like protein spoVR - - ko:K06415 - - - - ko00000 - - - SpoVR k59_107677_1 1499967.BAYZ01000028_gene1306 1.46e-104 310.0 COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid transport system / permease component livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_159541_1 111781.Lepto7376_3756 2e-15 81.3 COG1572@1|root,COG3209@1|root,COG3210@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - CARDB,RHS_repeat k59_68906_1 335543.Sfum_2497 4.46e-51 176.0 COG4591@1|root,COG4591@2|Bacteria,1RD9H@1224|Proteobacteria,43AMQ@68525|delta/epsilon subdivisions,2X61T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_100721_1 1121405.dsmv_1372 4.17e-88 272.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,2MHZV@213118|Desulfobacterales 28221|Deltaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_133715_1 1232437.KL661988_gene57 1.1e-31 120.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,42NX7@68525|delta/epsilon subdivisions,2WQ35@28221|Deltaproteobacteria,2MIN6@213118|Desulfobacterales 28221|Deltaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_133715_2 1232437.KL661988_gene58 5.36e-32 114.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,42VAB@68525|delta/epsilon subdivisions,2WR6X@28221|Deltaproteobacteria,2MKJM@213118|Desulfobacterales 28221|Deltaproteobacteria N Role in flagellar biosynthesis fliQ - - ko:K02420,ko:K03227 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 - - Bac_export_3 k59_133715_3 871963.Desdi_2861 2.15e-38 136.0 COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,260DF@186807|Peptococcaceae 186801|Clostridia N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_113970_3 1265502.KB905944_gene735 1.3e-11 67.0 COG3023@1|root,COG3023@2|Bacteria,1RJJT@1224|Proteobacteria,2VVER@28216|Betaproteobacteria,4AHVK@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - - - - - - - - - - - Amidase_2 k59_113970_4 1408473.JHXO01000008_gene2597 1.54e-77 244.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,2FRJR@200643|Bacteroidia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_139651_1 1122998.AUHZ01000002_gene2229 4.43e-08 55.5 COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4DPAW@85009|Propionibacteriales 201174|Actinobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_110014_2 1049564.TevJSym_bp00060 2.94e-62 211.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_31943_2 1049564.TevJSym_ah00920 5.55e-18 80.1 2AS0D@1|root,31HCK@2|Bacteria,1RH91@1224|Proteobacteria,1S6TH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_200045_1 522772.Dacet_0991 6.19e-74 224.0 COG1943@1|root,COG1943@2|Bacteria,2GGJ9@200930|Deferribacteres 200930|Deferribacteres L to the N-terminal region of - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_12811_1 1049564.TevJSym_ao00510 6.71e-103 306.0 COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_76963_1 1211640.K4JUL5_9CAUD 1.47e-32 141.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_136000_1 748247.AZKH_2578 0.0 1207.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KUC8@206389|Rhodocyclales 206389|Rhodocyclales V Protein export membrane protein - - - ko:K18902 - M00698 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_193945_2 1121035.AUCH01000007_gene436 6.52e-75 231.0 COG0664@1|root,COG0664@2|Bacteria,1RJU7@1224|Proteobacteria,2VZHQ@28216|Betaproteobacteria,2KYES@206389|Rhodocyclales 206389|Rhodocyclales K Cyclic nucleotide-monophosphate binding domain - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_142066_2 870187.Thini_4009 3e-262 725.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,1RSFD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein alpha chain nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_31953_3 105559.Nwat_0946 7.32e-32 123.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WX0W@135613|Chromatiales 135613|Chromatiales N transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_5423_1 1121396.KB893001_gene3963 1.48e-53 177.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,42W3U@68525|delta/epsilon subdivisions,2WSFC@28221|Deltaproteobacteria 28221|Deltaproteobacteria K transcriptional regulator - - - - - - - - - - - - DUF1956,TetR_N k59_90405_2 156889.Mmc1_2438 5.36e-44 161.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Na phosphate symporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_57300_1 1049564.TevJSym_aa01740 2.95e-22 95.9 COG1226@1|root,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,Na_H_Exchanger,TrkA_C,TrkA_N k59_57300_3 1049564.TevJSym_aa01720 5.36e-33 125.0 COG0666@1|root,COG0666@2|Bacteria,1RFV0@1224|Proteobacteria,1S50I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ankyrin repeat - - - ko:K06867 - - - - ko00000 - - - Ank_2,Ank_4,Ank_5 k59_57300_4 1049564.TevJSym_aa01710 2.69e-36 124.0 2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1JB6N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_136016_1 335543.Sfum_1603 2.13e-54 175.0 COG2344@1|root,COG2344@2|Bacteria,1R55V@1224|Proteobacteria,42M2S@68525|delta/epsilon subdivisions,2WM6N@28221|Deltaproteobacteria,2MQEC@213462|Syntrophobacterales 28221|Deltaproteobacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N k59_136016_2 96561.Dole_0631 4.6e-30 110.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MKRV@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_51643_1 570952.ATVH01000013_gene3073 5.53e-41 147.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,2JQS8@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_25806_1 933262.AXAM01000016_gene188 1.36e-92 293.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2MIKM@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_206716_1 1545915.JROG01000003_gene1224 1.77e-71 235.0 COG0467@1|root,COG4983@1|root,COG0467@2|Bacteria,COG4983@2|Bacteria,1R17Z@1224|Proteobacteria,2TYY5@28211|Alphaproteobacteria,2K6TU@204457|Sphingomonadales 204457|Sphingomonadales T Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - - - - - - - - - - - k59_142090_1 335543.Sfum_2394 1.74e-81 252.0 COG0535@1|root,COG0535@2|Bacteria,1R8PU@1224|Proteobacteria,42Q6I@68525|delta/epsilon subdivisions,2WKZV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_161912_1 269482.Bcep1808_6601 1.83e-140 408.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K21K@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,Intron_maturas2,RVT_1 k59_193981_1 1121405.dsmv_0225 8.06e-57 189.0 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,42R83@68525|delta/epsilon subdivisions,2WN00@28221|Deltaproteobacteria,2MJHD@213118|Desulfobacterales 28221|Deltaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_116148_1 1232410.KI421413_gene593 1.68e-94 285.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2WJQR@28221|Deltaproteobacteria,43S21@69541|Desulfuromonadales 28221|Deltaproteobacteria F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_193984_1 1158292.JPOE01000005_gene1001 2.97e-108 325.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - DDE_3,HTH_23 k59_18761_1 644282.Deba_2152 8.56e-14 68.9 COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_18761_2 1265505.ATUG01000001_gene3027 3.06e-55 174.0 COG1908@1|root,COG1908@2|Bacteria,1MZ7V@1224|Proteobacteria,42UHS@68525|delta/epsilon subdivisions,2WQMX@28221|Deltaproteobacteria,2MNI6@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_25816_2 477228.YO5_14955 8.92e-195 553.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,1Z2PY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_77002_1 1049564.TevJSym_aj00210 3.65e-175 515.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_155058_1 877421.AUJT01000031_gene3596 2.26e-05 54.7 COG2211@1|root,COG2211@2|Bacteria,1UK7T@1239|Firmicutes,24CXB@186801|Clostridia,27K4N@186928|unclassified Lachnospiraceae 186801|Clostridia G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_18771_1 435832.HMPREF0604_01335 7.67e-14 71.2 COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,2VJER@28216|Betaproteobacteria,2KQ54@206351|Neisseriales 206351|Neisseriales S SPFH Band 7 PHB domain protein yqiK - - - - - - - - - - - Band_7,Flot k59_18771_2 1121396.KB892917_gene102 3.27e-35 127.0 COG1585@1|root,COG1585@2|Bacteria,1RG29@1224|Proteobacteria,42Y3F@68525|delta/epsilon subdivisions,2WUYI@28221|Deltaproteobacteria,2MN9K@213118|Desulfobacterales 28221|Deltaproteobacteria OU Protein of unknown function (DUF1449) - - - - - - - - - - - - DUF1449 k59_161921_1 118005.AWNK01000013_gene890 2.46e-56 195.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_5438_1 631362.Thi970DRAFT_04863 5.46e-121 357.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_5438_3 1049564.TevJSym_ad01410 3.42e-213 594.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1J4PA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935 Aminotran_5 k59_5438_4 1049564.TevJSym_ad01400 0.0 1090.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1J52I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_18776_1 990073.ATHU01000001_gene853 5.95e-11 61.2 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2YMYI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_18776_2 1304885.AUEY01000006_gene724 1.66e-54 176.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2MIR4@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_206732_1 880072.Desac_0943 2.8e-37 130.0 COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,434CW@68525|delta/epsilon subdivisions,2X34J@28221|Deltaproteobacteria,2MRVR@213462|Syntrophobacterales 28221|Deltaproteobacteria S Thioesterase - - - - - - - - - - - - - k59_206732_2 313625.BL107_16045 9.39e-15 75.5 COG0084@1|root,COG0084@2|Bacteria,1G1SK@1117|Cyanobacteria,1GZ28@1129|Synechococcus 1117|Cyanobacteria L Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr) dtd3 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_155064_1 439235.Dalk_3918 3.17e-62 214.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria,2MPM5@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MASE1,PAS_9,Response_reg k59_5441_1 203120.LEUM_1980 8.68e-16 81.6 2DY5Q@1|root,34896@2|Bacteria,1VZDZ@1239|Firmicutes,4HZ9A@91061|Bacilli,4AY9W@81850|Leuconostocaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_25820_1 443143.GM18_4037 1.83e-122 394.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_181103_2 222534.KB893717_gene2190 8.91e-54 179.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4EU28@85013|Frankiales 201174|Actinobacteria V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_194006_1 1307436.PBF_19658 2.12e-19 96.3 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4HC0U@91061|Bacilli,1ZEUY@1386|Bacillus 91061|Bacilli L HNH nucleases - - - - - - - - - - - - GIIM,RVT_1 k59_90677_1 1322246.BN4_12497 2.79e-73 229.0 COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,42SKW@68525|delta/epsilon subdivisions,2X87K@28221|Deltaproteobacteria,2MHJ6@213115|Desulfovibrionales 28221|Deltaproteobacteria S DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_148967_5 1175306.GWL_26350 1.43e-29 115.0 2ECU6@1|root,336RP@2|Bacteria,1N8GM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_181408_1 305700.B447_10693 6.81e-20 91.3 COG5164@1|root,COG5164@2|Bacteria,1RG2G@1224|Proteobacteria,2VW61@28216|Betaproteobacteria 28216|Betaproteobacteria K Flagellar Assembly Protein A - - - - - - - - - - - - - k59_25915_1 1177154.Y5S_01973 1.81e-20 88.2 28JTN@1|root,2Z9IV@2|Bacteria,1RCK3@1224|Proteobacteria,1S21G@1236|Gammaproteobacteria,1XPME@135619|Oceanospirillales 135619|Oceanospirillales S Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_25915_2 349521.HCH_01177 5.83e-176 499.0 COG1846@1|root,COG1846@2|Bacteria,1RETW@1224|Proteobacteria,1S8N9@1236|Gammaproteobacteria,1XPM8@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional regulator - - - - - - - - - - - - - k59_103158_1 220664.PFL_2989 0.0 1087.0 COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YUIV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Ketoacyl-synthetase C-terminal extension - - - ko:K15675 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_1_2,Aminotran_3,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_103158_2 1174528.JH992893_gene5766 4.81e-55 207.0 COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae 1117|Cyanobacteria Q Ketoacyl-synthetase C-terminal extension - - - - - - - - - - - - Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_57597_2 1049564.TevJSym_af00770 5.72e-70 215.0 COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,1SD4C@1236|Gammaproteobacteria,1J72M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0526 Thiol-disulfide isomerase and thioredoxins resA - - - - - - - - - - - AhpC-TSA k59_142442_1 502025.Hoch_3372 1.01e-71 239.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2YUNH@29|Myxococcales 28221|Deltaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_181412_1 227377.CBU_1509 4.11e-104 324.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1JD0N@118969|Legionellales 118969|Legionellales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_77386_1 349521.HCH_06299 2.75e-39 150.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,Response_reg,TPR_12,TPR_8 k59_84262_3 1049564.TevJSym_ad01420 4.09e-231 642.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_155388_1 1121935.AQXX01000055_gene2911 1.42e-56 182.0 COG0419@1|root,COG0419@2|Bacteria,1R040@1224|Proteobacteria 1224|Proteobacteria L Plasmid replication region DNA-binding N-term - - - - - - - - - - - - KfrA_N k59_18972_1 1049564.TevJSym_al00490 2.31e-71 243.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1J5F4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S internalization-related competence protein ComEC Rec2 ycaI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_142452_1 338963.Pcar_0911 7.66e-71 233.0 COG2199@1|root,COG2984@1|root,COG2984@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - ABC_sub_bind,GAF,GGDEF,PAS_2,PHY k59_103164_1 1049564.TevJSym_an00380 3.71e-200 565.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J4EJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the pyruvate kinase family pykA GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 PK,PK_C k59_103164_2 1458427.BAWN01000011_gene665 3.91e-78 241.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,4AC31@80864|Comamonadaceae 28216|Betaproteobacteria G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_18984_1 880072.Desac_2814 8.86e-146 424.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MQFX@213462|Syntrophobacterales 28221|Deltaproteobacteria I Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta) - - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_142469_1 1121405.dsmv_2798 1.02e-111 328.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2MI2P@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_181436_3 1121403.AUCV01000003_gene1738 5.91e-26 103.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1R2HC@1224|Proteobacteria,42VJW@68525|delta/epsilon subdivisions,2WR7V@28221|Deltaproteobacteria,2MPPK@213118|Desulfobacterales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - - k59_32342_2 472759.Nhal_3875 2.5e-74 243.0 COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,1S781@1236|Gammaproteobacteria,1X15N@135613|Chromatiales 135613|Chromatiales S ATP-grasp domain - - - - - - - - - - - - ATP-grasp_3 k59_155413_1 96561.Dole_0968 1.14e-70 221.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,2MJFA@213118|Desulfobacterales 28221|Deltaproteobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_142472_1 1167006.UWK_01819 4.97e-80 262.0 COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MIN1@213118|Desulfobacterales 28221|Deltaproteobacteria J cysteinyl-tRNA synthetase cysM - 2.5.1.47,6.1.1.16 ko:K01738,ko:K01883,ko:K12339 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,PALP,tRNA-synt_1e k59_90726_2 765913.ThidrDRAFT_3830 4.09e-70 218.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales 135613|Chromatiales S pfam ammecr1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_181442_1 2340.JV46_24000 5.72e-164 466.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1J4R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_57645_1 660470.Theba_2373 1.52e-28 119.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GCR9@200918|Thermotogae 200918|Thermotogae I PFAM ATPase, BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_1459_1 1123253.AUBD01000002_gene1136 8.76e-05 51.2 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1X4CP@135614|Xanthomonadales 135614|Xanthomonadales M RHS Repeat - - - - - - - - - - - - DUF4329,RHS_repeat k59_105285_1 2340.JV46_16680 3.41e-98 290.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1J6IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G HAD-hyrolase-like gph GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756 HAD_2 k59_8144_1 153948.NAL212_0013 1.52e-107 315.0 COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria 28216|Betaproteobacteria L ISXO2-like transposase domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595 k59_150906_1 933262.AXAM01000139_gene294 9.71e-77 252.0 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_176731_1 2340.JV46_22050 6.15e-47 162.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1J58N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_176731_2 1049564.TevJSym_as00710 1.82e-126 371.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404 GlutR_N,GlutR_dimer,Shikimate_DH k59_157225_2 439235.Dalk_3780 2.81e-59 197.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM carboxyl transferase - - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_47027_1 335543.Sfum_2329 7.39e-148 420.0 COG2819@1|root,COG2819@2|Bacteria,1RAB4@1224|Proteobacteria,42WZ1@68525|delta/epsilon subdivisions,2WTDK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Putative esterase - - - - - - - - - - - - Esterase k59_40739_1 604331.AUHY01000048_gene2130 5.26e-28 107.0 COG0517@1|root,COG0517@2|Bacteria,1WMQJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Domain in cystathionine beta-synthase and other proteins. - - - ko:K04767 - - - - ko00000 - - - CBS k59_21201_2 1049564.TevJSym_aa00700 6.1e-74 230.0 COG1969@1|root,COG1969@2|Bacteria 2|Bacteria C respiratory electron transport chain - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_21201_3 1049564.TevJSym_aa00730 1.29e-91 272.0 COG0566@1|root,COG0566@2|Bacteria,1Q9ZC@1224|Proteobacteria,1SWHA@1236|Gammaproteobacteria,1JBBP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J SpoU rRNA Methylase family - - - - - - - - - - - - SpoU_methylase k59_21201_4 1049564.TevJSym_aa00740 1.94e-70 218.0 COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1S69R@1236|Gammaproteobacteria,1J6BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphoglycerate mutase family cobC - 3.1.3.73,5.4.2.12 ko:K02226,ko:K15634 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00122 R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_144465_2 1121033.AUCF01000030_gene204 3.59e-104 315.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,2JS4E@204441|Rhodospirillales 204441|Rhodospirillales P Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_144465_3 1049564.TevJSym_bi00080 4.03e-176 531.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - DUF3365,EAL,GGDEF,PAS_3,PAS_9,Response_reg k59_92533_1 194867.ALBQ01000005_gene1647 9.6e-174 495.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria,2K2KE@204457|Sphingomonadales 204457|Sphingomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_66381_1 83406.HDN1F_18160 3.45e-40 146.0 28HMN@1|root,2Z7W5@2|Bacteria,1N798@1224|Proteobacteria,1S0PZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - DUF4400 k59_27613_1 1313304.CALK_1162 1.66e-82 253.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity uxs - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_60066_1 941449.dsx2_2965 8.8e-21 85.9 COG2044@1|root,COG2044@2|Bacteria,1RIFN@1224|Proteobacteria,42UMB@68525|delta/epsilon subdivisions,2WQMD@28221|Deltaproteobacteria,2MD9S@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM DsrE family protein - - - - - - - - - - - - DrsE k59_34149_1 550540.Fbal_0119 1.31e-42 157.0 COG1262@1|root,COG2319@1|root,COG2885@1|root,COG1262@2|Bacteria,COG2319@2|Bacteria,COG2885@2|Bacteria,1NQ5K@1224|Proteobacteria 1224|Proteobacteria M PFAM Formylglycine-generating sulfatase enzyme - - 2.7.11.1 ko:K11912,ko:K20333 ko02024,ko02025,ko03070,map02024,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - FGE-sulfatase,PEGA,Pkinase,TIR_2 k59_125004_1 1121918.ARWE01000001_gene5 5.15e-70 223.0 COG0697@1|root,COG0697@2|Bacteria,1RE85@1224|Proteobacteria,42RRX@68525|delta/epsilon subdivisions,2WNMU@28221|Deltaproteobacteria,43ST0@69541|Desulfuromonadales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_105293_1 335543.Sfum_1832 2.5e-39 137.0 2EHG8@1|root,33B84@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DinB_2 k59_170446_2 469383.Cwoe_4660 8.14e-08 64.7 COG1361@1|root,COG1361@2|Bacteria,2I2W6@201174|Actinobacteria 201174|Actinobacteria MO Proprotein convertase P-domain - - - - - - - - - - - - P_proprotein,Peptidase_S8 k59_170446_3 857087.Metme_1124 8.61e-137 440.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_118558_1 502025.Hoch_2673 5.62e-24 104.0 COG0265@1|root,COG0265@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria,2YXPK@29|Myxococcales 28221|Deltaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_111944_1 1049564.TevJSym_bi00330 5.35e-150 449.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1J4WG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_21212_1 765910.MARPU_12930 3.8e-77 244.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_131553_1 1049564.TevJSym_ad01530 1.45e-11 63.9 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1J5W9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_131553_2 1049564.TevJSym_ad01540 7.18e-116 337.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1J5PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q E COG1126 ABC-type polar amino acid transport system, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_111946_1 90813.JQMT01000001_gene1057 1.25e-57 191.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,461TE@72273|Thiotrichales 72273|Thiotrichales L Homeodomain-like domain - - - - - - - - - - - - HTH_38,rve k59_14366_1 1049564.TevJSym_ak00980 2.4e-24 93.6 2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SGID@1236|Gammaproteobacteria,1J7DD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM TIGR02449 family protein VL23_04670 - - ko:K09892 - - - - ko00000,ko03036 - - - - k59_14366_2 745411.B3C1_14620 2.03e-14 75.5 COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1J79S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0149 family ygfB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09895 - - - - ko00000 - - - UPF0149 k59_14366_3 1049564.TevJSym_ak01000 4.6e-39 140.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_27622_1 1123073.KB899241_gene3528 6.38e-42 161.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_163755_2 1157708.KB907450_gene6568 3.44e-42 142.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2VSP4@28216|Betaproteobacteria,4AEC0@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM nitrite reductase NAD(P)H , small subunit nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_163755_3 1096930.L284_11940 1.54e-18 85.5 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,2K03B@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_144480_2 1121085.AUCI01000002_gene4021 8.57e-18 76.3 29SGJ@1|root,30DMJ@2|Bacteria,1UBFB@1239|Firmicutes,4IMU0@91061|Bacilli,1ZKUH@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_66556_1 933262.AXAM01000003_gene2829 3.77e-89 272.0 COG0697@1|root,COG0697@2|Bacteria,1N469@1224|Proteobacteria,42QXU@68525|delta/epsilon subdivisions,2WN2T@28221|Deltaproteobacteria,2MJKS@213118|Desulfobacterales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_195960_1 396588.Tgr7_2723 7.93e-54 176.0 COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria 1224|Proteobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_183658_2 439235.Dalk_1684 5.58e-26 100.0 2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,42W32@68525|delta/epsilon subdivisions,2WQGF@28221|Deltaproteobacteria,2MKQ3@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_183658_3 96561.Dole_1192 1.1e-32 124.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,42SB8@68525|delta/epsilon subdivisions,2WPKF@28221|Deltaproteobacteria,2MJSC@213118|Desulfobacterales 28221|Deltaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_105461_1 641491.DND132_2026 1.47e-33 127.0 COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,42MDW@68525|delta/epsilon subdivisions,2WKQK@28221|Deltaproteobacteria,2M92X@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Glycosyltransferase 28 - - - - - - - - - - - - Glyco_tran_28_C k59_92818_1 1441629.PCH70_25320 1.04e-59 209.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1Z9BF@136849|Pseudomonas syringae group 1236|Gammaproteobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_131749_1 1089550.ATTH01000001_gene2440 1.34e-172 498.0 COG1053@1|root,COG1053@2|Bacteria,4NHXK@976|Bacteroidetes,1FJ4E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_40992_1 1049564.TevJSym_az00070 0.0 898.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family phsA - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_118780_2 96561.Dole_2198 2.44e-05 45.1 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42RDZ@68525|delta/epsilon subdivisions,2WQ4Z@28221|Deltaproteobacteria,2MK4R@213118|Desulfobacterales 28221|Deltaproteobacteria S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_144717_1 215803.DB30_3093 6.36e-25 108.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2YZE4@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_176979_1 765912.Thimo_2903 7.53e-34 122.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_14515_2 69395.JQLZ01000004_gene816 7.39e-19 81.6 COG1359@1|root,COG1359@2|Bacteria,1N8V7@1224|Proteobacteria,2UFYD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_14515_3 1472716.KBK24_0104250 1.68e-19 82.4 2FB4Q@1|root,343B3@2|Bacteria,1P0ZD@1224|Proteobacteria,2W4GJ@28216|Betaproteobacteria,1K997@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_21475_1 1333856.L686_08605 1.75e-52 179.0 2DCRG@1|root,32U03@2|Bacteria,1MZFR@1224|Proteobacteria,1SNSI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_125263_1 768671.ThimaDRAFT_1981 4.03e-28 103.0 COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria,1SJ0G@1236|Gammaproteobacteria,1X1K5@135613|Chromatiales 135613|Chromatiales IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_125263_2 589865.DaAHT2_1753 1.29e-07 52.4 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MN6X@213118|Desulfobacterales 28221|Deltaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_73017_1 1250005.PHEL85_1858 1.65e-06 62.4 COG0726@1|root,COG1404@1|root,COG3227@1|root,COG4733@1|root,COG0726@2|Bacteria,COG1404@2|Bacteria,COG3227@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - DUF5011,MAM,Peptidase_S8,SLH,fn3 k59_73017_2 203122.Sde_2047 4.92e-40 147.0 COG0760@1|root,COG0760@2|Bacteria,1RFHH@1224|Proteobacteria,1S4J2@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_73017_3 498211.CJA_2519 2.54e-80 250.0 COG0760@1|root,COG0760@2|Bacteria,1PK21@1224|Proteobacteria,1S180@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 k59_163951_2 1249627.D779_2260 1.16e-54 177.0 COG3193@1|root,COG3193@2|Bacteria,1REZG@1224|Proteobacteria,1S5K5@1236|Gammaproteobacteria,1WYDR@135613|Chromatiales 135613|Chromatiales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_163951_3 765912.Thimo_2612 6.91e-40 140.0 2B5BG@1|root,31Y5N@2|Bacteria,1RJ1N@1224|Proteobacteria,1S56J@1236|Gammaproteobacteria,1WYC6@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_163951_4 1249627.D779_1692 4.38e-52 170.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWVI@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_112146_1 1173024.KI912152_gene349 6.64e-21 94.4 COG4185@1|root,COG4185@2|Bacteria,1G56J@1117|Cyanobacteria 1117|Cyanobacteria S zeta toxin - - - - - - - - - - - - Zeta_toxin k59_79888_2 713586.KB900536_gene1280 4.33e-76 251.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K07713,ko:K07715 ko02020,ko02024,map02020,map02024 M00499,M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_79888_3 187272.Mlg_0219 7.94e-127 385.0 COG4191@1|root,COG4191@2|Bacteria,1QVHZ@1224|Proteobacteria,1S2DC@1236|Gammaproteobacteria,1WZY5@135613|Chromatiales 135613|Chromatiales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_79888_4 159087.Daro_2602 1.31e-98 298.0 COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,2VIVQ@28216|Betaproteobacteria,2KUCY@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_79888_7 438753.AZC_3363 3.01e-66 220.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,3EY8Q@335928|Xanthobacteraceae 28211|Alphaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_79888_8 367737.Abu_0123 2.06e-71 234.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2YMUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_79888_10 981384.AEYW01000006_gene2442 2.13e-09 67.8 COG1036@1|root,COG1148@1|root,COG1036@2|Bacteria,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2TWJ4@28211|Alphaproteobacteria,4NAGY@97050|Ruegeria 28211|Alphaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_7 k59_79888_12 483216.BACEGG_01711 2.96e-10 69.7 COG0438@1|root,COG0438@2|Bacteria,4NEZI@976|Bacteroidetes,2FQFD@200643|Bacteroidia,4ASQM@815|Bacteroidaceae 976|Bacteroidetes M Glycosyltransferase, group 1 family protein - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_48987_1 765913.ThidrDRAFT_2876 8.52e-48 167.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales 135613|Chromatiales O smart pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_43247_2 525146.Ddes_1246 9.97e-13 68.9 COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2M8XJ@213115|Desulfovibrionales 28221|Deltaproteobacteria L AAA domain - - - - - - - - - - - - AAA_27 k59_204419_1 933262.AXAM01000008_gene1922 1.36e-98 306.0 COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MHPT@213118|Desulfobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_55040_2 357804.Ping_2327 1.47e-139 411.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,2QJ72@267894|Psychromonadaceae 1236|Gammaproteobacteria P Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_55040_5 314278.NB231_13701 1.28e-25 97.1 COG4691@1|root,COG4691@2|Bacteria,1NAMF@1224|Proteobacteria,1SD4G@1236|Gammaproteobacteria,1X1U3@135613|Chromatiales 135613|Chromatiales S Plasmid stability protein - - - - - - - - - - - - - k59_55040_6 305900.GV64_08345 1.15e-55 177.0 COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,1S79S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K07062 - - - - ko00000,ko01000,ko02048 - - - PIN k59_55040_7 743299.Acife_0668 1.07e-312 874.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,2NDFW@225057|Acidithiobacillales 225057|Acidithiobacillales L DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_55040_8 743299.Acife_0669 1.26e-157 456.0 COG0732@1|root,COG0732@2|Bacteria,1MXSQ@1224|Proteobacteria,1S320@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_55040_9 243265.plu4452 0.0 1077.0 COG0514@1|root,COG1040@1|root,COG0514@2|Bacteria,COG1040@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,Pribosyltran,RecQ_Zn_bind,UvrD-helicase,UvrD_C k59_55040_10 377629.TERTU_3910 1.88e-40 145.0 COG0758@1|root,COG0758@2|Bacteria,1Q7YP@1224|Proteobacteria,1RYGJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria LU Rossmann fold nucleotide-binding protein involved in DNA uptake - - - - - - - - - - - - DNA_processg_A k59_3085_1 44060.JODL01000008_gene1075 9.67e-10 61.2 COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria 201174|Actinobacteria K histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_36201_1 880072.Desac_2532 4.66e-167 485.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MQ8Y@213462|Syntrophobacterales 28221|Deltaproteobacteria H Thiamine pyrophosphate enzyme, central ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_68567_1 641147.HMPREF9021_01911 4.97e-109 332.0 28JM7@1|root,2Z9DS@2|Bacteria,1R8QS@1224|Proteobacteria,2VYJA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_185483_1 96561.Dole_2370 5.66e-11 62.4 2EC3H@1|root,3362D@2|Bacteria,1NDXP@1224|Proteobacteria,42WQJ@68525|delta/epsilon subdivisions,2WRNF@28221|Deltaproteobacteria,2MKWZ@213118|Desulfobacterales 28221|Deltaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_185483_2 1121422.AUMW01000023_gene2736 2.04e-40 141.0 COG1280@1|root,COG1280@2|Bacteria,1V725@1239|Firmicutes,24KQ7@186801|Clostridia,261QM@186807|Peptococcaceae 186801|Clostridia E PFAM Lysine exporter protein (LYSE YGGA) - - - - - - - - - - - - LysE k59_62159_1 485913.Krac_9893 1.61e-58 194.0 COG3547@1|root,COG3547@2|Bacteria,2G9MR@200795|Chloroflexi 200795|Chloroflexi L SPTR B7KVZ8 Transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_81585_1 1121403.AUCV01000132_gene3321 1.53e-88 262.0 COG0494@1|root,COG0494@2|Bacteria,1QU7P@1224|Proteobacteria 1224|Proteobacteria L belongs to the nudix hydrolase family - - - - - - - - - - - - NUDIX k59_152553_1 595460.RRSWK_03372 6.1e-26 112.0 COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IZND@203682|Planctomycetes 203682|Planctomycetes K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_191617_1 335543.Sfum_0651 8.17e-19 87.8 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MQZE@213462|Syntrophobacterales 28221|Deltaproteobacteria T Cache domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_191617_2 706587.Desti_4355 4.43e-32 115.0 COG1433@1|root,COG1433@2|Bacteria,1N799@1224|Proteobacteria,42V7X@68525|delta/epsilon subdivisions,2WRG1@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_191617_3 794903.OPIT5_26770 0.000221 45.8 COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia,3K7NF@414999|Opitutae 414999|Opitutae T sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_197606_1 335543.Sfum_1553 1.06e-233 647.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MQ8F@213462|Syntrophobacterales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_68569_1 323261.Noc_0728 2.64e-46 171.0 COG4935@1|root,COG4935@2|Bacteria,1NJV7@1224|Proteobacteria,1RN7Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_4 k59_139371_1 768671.ThimaDRAFT_3221 5.64e-23 91.3 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales 135613|Chromatiales S Membrane fusogenic activity - - - ko:K09806 - - - - ko00000 - - - BMFP k59_139371_2 768671.ThimaDRAFT_3222 4.21e-224 634.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales 135613|Chromatiales O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_165445_1 29850.GGTG_07475T0 5.66e-103 346.0 COG0076@1|root,KOG0629@2759|Eukaryota,39XNR@33154|Opisthokonta,3NXHR@4751|Fungi,3QN7V@4890|Ascomycota,215EZ@147550|Sordariomycetes 4751|Fungi E Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_165445_2 864051.BurJ1DRAFT_2704 2.15e-143 410.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VN0D@28216|Betaproteobacteria,1KKFJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_165445_3 395495.Lcho_3698 1.54e-31 112.0 COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2VSU2@28216|Betaproteobacteria,1KM5X@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_172101_1 105559.Nwat_2809 3.91e-34 128.0 COG0561@1|root,COG3100@1|root,COG0561@2|Bacteria,COG3100@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1WX4S@135613|Chromatiales 135613|Chromatiales S HAD-superfamily hydrolase, subfamily IIB - - - - - - - - - - - - S6PP,YcgL k59_204634_1 631362.Thi970DRAFT_01907 1.12e-59 206.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_165634_1 1298593.TOL_0049 1.45e-71 240.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XKSQ@135619|Oceanospirillales 135619|Oceanospirillales O Subtilase family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8,SLH k59_100630_1 326442.PSHAa0654 5.55e-36 144.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,2PZXA@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg,SBP_bac_3,dCache_1 k59_139550_1 1192759.AKIB01000017_gene1786 1.25e-75 249.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K9SN@204457|Sphingomonadales 204457|Sphingomonadales C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_113892_1 247490.KSU1_C0836 4.03e-49 162.0 COG1704@1|root,COG1704@2|Bacteria,2IZBC@203682|Planctomycetes 203682|Planctomycetes S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_133622_1 335543.Sfum_0306 1.16e-106 322.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MQXU@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_16182_1 880072.Desac_0500 1.77e-16 79.3 COG1804@1|root,COG1804@2|Bacteria,1NWFC@1224|Proteobacteria,4300F@68525|delta/epsilon subdivisions,2X2A6@28221|Deltaproteobacteria,2MRS4@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_62395_2 1469245.JFBG01000075_gene159 1.41e-22 100.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo k59_29634_1 933262.AXAM01000002_gene503 2.14e-95 296.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales 28221|Deltaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_3254_1 472759.Nhal_1155 1.3e-136 397.0 2C6D0@1|root,31F07@2|Bacteria,1RHBN@1224|Proteobacteria,1S7HH@1236|Gammaproteobacteria,1WX2B@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_36429_1 1266908.AQPB01000029_gene2127 3.17e-156 476.0 COG5001@1|root,COG5001@2|Bacteria,1R59J@1224|Proteobacteria 1224|Proteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_36429_3 765911.Thivi_0679 4.07e-145 421.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1WW5P@135613|Chromatiales 135613|Chromatiales J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_36429_4 1049564.TevJSym_an00630 1.79e-228 633.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1J4WN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_23391_1 439235.Dalk_3857 1.84e-82 253.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2MI2X@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_165636_1 261292.Nit79A3_2730 4.17e-160 469.0 COG3039@1|root,COG3039@2|Bacteria,1Q9GN@1224|Proteobacteria,2WCRD@28216|Betaproteobacteria,373TB@32003|Nitrosomonadales 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_16189_1 1121405.dsmv_2866 1.58e-97 300.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N16@68525|delta/epsilon subdivisions,2X73Y@28221|Deltaproteobacteria,2MJEF@213118|Desulfobacterales 28221|Deltaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle dppA - - ko:K02035,ko:K12368 ko02010,ko02024,ko02030,map02010,map02024,map02030 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_159430_1 706587.Desti_1309 2.32e-09 64.3 COG2202@1|root,COG2204@1|root,COG3852@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions 1224|Proteobacteria T histidine kinase A domain protein - - - - - - - - - - - - DUF3365,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_43579_1 561229.Dd1591_3149 1.23e-96 290.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,2JCDU@204037|Dickeya 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA k59_10412_1 1122201.AUAZ01000022_gene3082 1.16e-110 324.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,1RR82@1236|Gammaproteobacteria,466BC@72275|Alteromonadaceae 1236|Gammaproteobacteria D The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_107570_1 765913.ThidrDRAFT_4406 2.36e-99 302.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_165638_2 933262.AXAM01000081_gene2256 2.73e-62 194.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2WP5B@28221|Deltaproteobacteria,2MJHE@213118|Desulfobacterales 28221|Deltaproteobacteria O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_55165_1 221988.MS0108 5.52e-07 52.4 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria,1Y9ZN@135625|Pasteurellales 135625|Pasteurellales S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_55165_4 1278971.AOGF01000022_gene336 2.87e-07 58.2 COG3561@1|root,COG3561@2|Bacteria,1N1AT@1224|Proteobacteria,1RRY7@1236|Gammaproteobacteria,1Y8EQ@135625|Pasteurellales 135625|Pasteurellales K AntA/AntB antirepressor - - - ko:K07741 - - - - ko00000 - - - AntA,P22_AR_C k59_133633_1 1249627.D779_1903 1.35e-53 190.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales 135613|Chromatiales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_197805_1 396588.Tgr7_3298 1.91e-55 181.0 COG3655@1|root,COG3655@2|Bacteria,1QZZC@1224|Proteobacteria,1T4CQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_127704_1 566466.NOR53_3541 4.62e-46 172.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1J590@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase S8 family bprV - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PKD,Peptidase_S8 k59_23399_1 589865.DaAHT2_1923 7e-35 122.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42UWR@68525|delta/epsilon subdivisions,2WQRB@28221|Deltaproteobacteria,2MP1G@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_23399_2 452637.Oter_0749 3.28e-31 119.0 COG0839@1|root,COG0839@2|Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family ndhG - 1.6.5.3 ko:K00339,ko:K05578 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_68817_2 1089552.KI911559_gene1368 6.89e-141 402.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,2JS0N@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_68817_3 1515746.HR45_16040 7.44e-12 66.6 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1S0KW@1236|Gammaproteobacteria,2QEKC@267890|Shewanellaceae 1236|Gammaproteobacteria S Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_68817_4 631362.Thi970DRAFT_04985 2.19e-69 228.0 COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,1RRDP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_185741_1 357804.Ping_0433 5.09e-90 288.0 COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,1T0KQ@1236|Gammaproteobacteria,2QHBY@267894|Psychromonadaceae 1236|Gammaproteobacteria S Heparinase II/III N-terminus - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_193510_1 1166948.JPZL01000002_gene1868 1.34e-19 90.5 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria 1224|Proteobacteria C cytochrome cc43 - - ko:K17230 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001 - - - Cytochrom_C,Cytochrome_CBB3 k59_193510_2 768671.ThimaDRAFT_3371 2.29e-255 735.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_193510_3 1026882.MAMP_01952 8.87e-64 243.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,460B2@72273|Thiotrichales 72273|Thiotrichales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_115854_1 1121438.JNJA01000002_gene3578 8.79e-53 178.0 COG0535@1|root,COG0535@2|Bacteria,1R8PU@1224|Proteobacteria,42Q6I@68525|delta/epsilon subdivisions,2WKZV@28221|Deltaproteobacteria,2M9CA@213115|Desulfovibrionales 28221|Deltaproteobacteria S radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_102550_1 1242864.D187_005545 1.83e-142 407.0 COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,42QAR@68525|delta/epsilon subdivisions,2WKBY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM cyclase family protein - - - - - - - - - - - - Cyclase k59_4987_1 765913.ThidrDRAFT_4145 2.93e-266 760.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales 135613|Chromatiales U Hydrophobe Amphiphile Efflux-1 (HAE1) - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_102552_1 1123236.KB899380_gene2792 4e-54 179.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,466TA@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0104 CoaE k59_173733_1 933262.AXAM01000142_gene2436 3.48e-72 238.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MHMN@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_38708_1 555778.Hneap_2088 1.64e-34 131.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales 135613|Chromatiales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_56905_1 931276.Cspa_c06690 1.99e-07 55.5 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,36G86@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_89914_1 1356854.N007_21440 2.05e-29 116.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,27A1K@186823|Alicyclobacillaceae 91061|Bacilli L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_38711_1 195250.CM001776_gene949 8.49e-92 296.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_31547_1 1121033.AUCF01000027_gene2776 2.55e-83 263.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,2JQHM@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_180833_1 1120963.KB894521_gene5 2.54e-17 87.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,2Q12A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_167847_1 96561.Dole_1191 4.84e-70 234.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_174028_1 1121405.dsmv_3079 9.68e-97 286.0 COG0500@1|root,COG2226@2|Bacteria,1QU24@1224|Proteobacteria,43BNY@68525|delta/epsilon subdivisions,2X70A@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25 k59_76900_2 292415.Tbd_1536 2.26e-93 281.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KRK3@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_18620_1 909663.KI867150_gene488 8.63e-46 169.0 COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS_4,PAS_9 k59_141960_2 665942.HMPREF1022_02301 3.04e-10 62.8 2DC0H@1|root,2ZC7P@2|Bacteria,1RB77@1224|Proteobacteria,42YR6@68525|delta/epsilon subdivisions,2WU8M@28221|Deltaproteobacteria,2MEAZ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_199960_2 472759.Nhal_3611 1.08e-13 75.5 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1WXF1@135613|Chromatiales 135613|Chromatiales N PFAM GTP-binding signal recognition particle SRP54 G- domain - - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_135917_1 90813.JQMT01000001_gene1704 5.59e-33 120.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1SCRQ@1236|Gammaproteobacteria,462VA@72273|Thiotrichales 72273|Thiotrichales K ECF sigma factor - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_148663_1 1123400.KB904750_gene684 5.71e-219 629.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,460C5@72273|Thiotrichales 72273|Thiotrichales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ACBP,ECH_1 k59_174037_1 1121935.AQXX01000124_gene116 2.36e-07 59.7 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,1RP7J@1236|Gammaproteobacteria,1XH94@135619|Oceanospirillales 135619|Oceanospirillales G Hypothetical glycosyl hydrolase family 13 - - - ko:K11931 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - GHL13,Polysacc_deac_1 k59_180983_1 360104.CCC13826_0331 1.84e-71 230.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2YN7C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_102875_1 519989.ECTPHS_03854 2.16e-13 70.1 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_102875_2 743720.Psefu_0327 7.92e-28 108.0 COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria,1YYC2@136845|Pseudomonas putida group 1236|Gammaproteobacteria NT CheW domain protein chpC - - ko:K06598 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035 - - - CheW k59_102875_3 1232683.ADIMK_2632 1.23e-49 163.0 COG1585@1|root,COG1585@2|Bacteria,1RJHH@1224|Proteobacteria,1SZTE@1236|Gammaproteobacteria,46BS5@72275|Alteromonadaceae 1236|Gammaproteobacteria OU NfeD-like C-terminal, partner-binding - - - - - - - - - - - - NfeD k59_167865_1 335543.Sfum_2411 1.13e-114 340.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MR9A@213462|Syntrophobacterales 28221|Deltaproteobacteria O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_31800_1 1249627.D779_4152 2.86e-55 180.0 COG2897@1|root,COG2897@2|Bacteria,1QVX5@1224|Proteobacteria,1T2MK@1236|Gammaproteobacteria,1WW70@135613|Chromatiales 135613|Chromatiales P Rhodanese-like domain - - - - - - - - - - - - Rhodanese k59_31800_3 1049564.TevJSym_ah00930 3.99e-67 209.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1J7ZS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA soxA - 1.8.2.2 ko:K17222,ko:K19713 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - - k59_64676_1 1123319.AUBE01000007_gene3505 2.55e-150 439.0 COG2124@1|root,COG2124@2|Bacteria,2GJ30@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - 1.14.99.49 ko:K20420 ko01059,ko01130,map01059,map01130 M00830 R10796 RC00490 ko00000,ko00001,ko00002,ko01000 - - - p450 k59_64676_3 1278309.KB907101_gene758 1.74e-06 49.3 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1XHSB@135619|Oceanospirillales 135619|Oceanospirillales P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_141969_1 177437.HRM2_41160 3.15e-99 306.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MIPZ@213118|Desulfobacterales 28221|Deltaproteobacteria C Phosphoenolpyruvate carboxykinase N-terminal domain pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2638 PEPCK_C,PEPCK_N k59_5338_1 246194.CHY_2643 8.76e-47 163.0 COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,25D5K@186801|Clostridia,42JFB@68295|Thermoanaerobacterales 186801|Clostridia U transposase gene. There are two copies of the ISChy3 element in this genome - - - - - - - - - - - - AAA_22 k59_161796_1 1049564.TevJSym_ai00980 1.94e-28 103.0 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1J6XN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_161796_2 1279017.AQYJ01000024_gene999 2.51e-130 384.0 COG2223@1|root,COG2223@2|Bacteria,1MW71@1224|Proteobacteria,1RN10@1236|Gammaproteobacteria,466AU@72275|Alteromonadaceae 1236|Gammaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_174061_1 177437.HRM2_16090 3.05e-42 157.0 COG3829@1|root,COG3829@2|Bacteria,1N4M6@1224|Proteobacteria,42M38@68525|delta/epsilon subdivisions,2WIR0@28221|Deltaproteobacteria,2MJ85@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_5342_1 1089546.AQUI01000002_gene2290 9.45e-77 242.0 COG0346@1|root,COG0346@2|Bacteria,2IAYN@201174|Actinobacteria,407X9@622450|Actinopolysporales 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K15975 - - - - ko00000 - - - Glyoxalase k59_64686_1 1123508.JH636439_gene1753 7.13e-227 639.0 COG3119@1|root,COG3119@2|Bacteria,2J2DF@203682|Planctomycetes 203682|Planctomycetes P Sulfatase - - - - - - - - - - - - Sulfatase k59_90285_1 561177.ANHYDRO_00681 1.21e-20 94.7 COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,22FXD@1570339|Peptoniphilaceae 186801|Clostridia S Competence protein ComEC comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Ada_Zn_binding,Lactamase_B k59_180992_1 247490.KSU1_D0964 1.54e-71 231.0 COG0154@1|root,COG0154@2|Bacteria,2IXW5@203682|Planctomycetes 203682|Planctomycetes J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_161799_2 1298593.TOL_3316 2.92e-46 152.0 2DSPH@1|root,33GXT@2|Bacteria,1NG9C@1224|Proteobacteria,1SGF6@1236|Gammaproteobacteria,1XQI0@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_161799_3 349521.HCH_00135 3.84e-48 163.0 2DSPH@1|root,33GXT@2|Bacteria,1NG9C@1224|Proteobacteria,1SGF6@1236|Gammaproteobacteria,1XQI0@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_25714_1 290397.Adeh_2168 1.1e-43 147.0 COG3829@1|root,COG3829@2|Bacteria,1QVJM@1224|Proteobacteria,43CC9@68525|delta/epsilon subdivisions,2X7N5@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PAS sensor protein - - - - - - - - - - - - PAS_4 k59_12710_1 1287116.X734_31925 1.54e-68 226.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_148690_1 2340.JV46_16680 5.21e-91 271.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1J6IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G HAD-hyrolase-like gph GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756 HAD_2 k59_148690_2 1049564.TevJSym_ag00470 3.95e-154 434.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1J4M6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0155,iYL1228.KPN_03757 Ribul_P_3_epim k59_83864_2 886293.Sinac_7595 1.19e-36 128.0 COG3436@1|root,COG3436@2|Bacteria,2J11P@203682|Planctomycetes 203682|Planctomycetes L PFAM IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_109928_1 439235.Dalk_5190 1.41e-58 196.0 COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_18661_1 880072.Desac_0868 4.75e-29 115.0 COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,42RYV@68525|delta/epsilon subdivisions,2WNEF@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_18661_2 880072.Desac_0869 2.15e-87 269.0 COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_90308_1 1121396.KB893090_gene200 1.57e-23 99.8 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42QZ3@68525|delta/epsilon subdivisions,2WN3V@28221|Deltaproteobacteria,2MMJF@213118|Desulfobacterales 28221|Deltaproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_180997_1 880072.Desac_1676 2.39e-45 164.0 COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2MR85@213462|Syntrophobacterales 28221|Deltaproteobacteria H Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_167884_1 713587.THITH_00820 2.15e-126 384.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales 135613|Chromatiales L DEAD DEAH box - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_83868_1 1049564.TevJSym_be00190 6.38e-82 254.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1J6G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840 - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_83868_2 84531.JMTZ01000073_gene2121 7.54e-101 298.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1X4FR@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_83868_3 911239.CF149_04196 3.65e-107 315.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_148698_2 748247.AZKH_0333 1.24e-40 144.0 COG3245@1|root,COG3245@2|Bacteria,1RCEB@1224|Proteobacteria,2VQIB@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C554,Cytochrome_CBB3 k59_5371_1 933262.AXAM01000036_gene2170 8.17e-60 206.0 COG0613@1|root,COG0613@2|Bacteria,1Q7I9@1224|Proteobacteria,42M1D@68525|delta/epsilon subdivisions,2WIMC@28221|Deltaproteobacteria,2MIFA@213118|Desulfobacterales 28221|Deltaproteobacteria S PHP domain protein - - - - - - - - - - - - - k59_109940_1 1049564.TevJSym_bp00050 1.66e-99 291.0 COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,1T1KA@1236|Gammaproteobacteria,1JC0E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019222,GO:0019439,GO:0034353,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_167886_1 765913.ThidrDRAFT_0566 2.62e-43 150.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1S30B@1236|Gammaproteobacteria,1X0PA@135613|Chromatiales 135613|Chromatiales HJ Belongs to the RimK family - - - - - - - - - - - - RimK k59_167886_2 765913.ThidrDRAFT_0567 2.27e-101 307.0 COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,1S4ZR@1236|Gammaproteobacteria 1236|Gammaproteobacteria H triphosphoribosyl-dephospho-CoA - - 2.4.2.52 ko:K05966 ko02020,map02020 - R09675 RC00049,RC00063 ko00000,ko00001,ko01000 - - - CitG k59_25740_1 457398.HMPREF0326_05604 3.63e-19 90.1 COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2M8EC@213115|Desulfovibrionales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_102906_1 1167006.UWK_02231 1.17e-204 585.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_12938_3 1049564.TevJSym_ax00380 6.89e-72 230.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_142312_2 1382303.JPOM01000001_gene432 6.75e-11 61.2 COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2UDE8@28211|Alphaproteobacteria,2KGYX@204458|Caulobacterales 204458|Caulobacterales O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_124795_2 1121035.AUCH01000018_gene2751 2.86e-12 70.5 2EBVI@1|root,335UY@2|Bacteria,1R0Q7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_79605_1 1123053.AUDG01000031_gene952 4.15e-25 118.0 COG1262@1|root,COG1520@1|root,COG2931@1|root,COG3209@1|root,COG1262@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1QX0G@1224|Proteobacteria,1T32B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - - k59_46842_1 335543.Sfum_1977 2.15e-99 317.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_85743_1 573370.DMR_34780 3.21e-66 225.0 COG0613@1|root,COG0613@2|Bacteria,1Q7I9@1224|Proteobacteria,42M1D@68525|delta/epsilon subdivisions,2WIMC@28221|Deltaproteobacteria,2M8ZF@213115|Desulfovibrionales 28221|Deltaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair - - - - - - - - - - - - - k59_111775_1 1238182.C882_0340 3.05e-78 246.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQEC@204441|Rhodospirillales 204441|Rhodospirillales G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_92335_1 1121405.dsmv_2755 5.83e-77 246.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MHSH@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,R3H k59_33957_1 555079.Toce_2101 8.78e-42 143.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,42GM6@68295|Thermoanaerobacterales 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_72724_1 330214.NIDE2578 3.16e-29 114.0 2F9RH@1|root,3421I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_8000_1 631362.Thi970DRAFT_02085 1.48e-114 343.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales 135613|Chromatiales C TIGRFAM cytochrome c oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_14228_2 83406.HDN1F_20890 2.17e-16 83.2 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_40528_1 445973.CLOBAR_00933 1.62e-115 351.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,25QRD@186804|Peptostreptococcaceae 186801|Clostridia H Formyltetrahydrofolate synthetase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_46843_1 1121405.dsmv_3570 6.42e-168 480.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_118353_1 999141.GME_04957 4.05e-52 165.0 COG3668@1|root,COG3668@2|Bacteria,1N75M@1224|Proteobacteria,1S67C@1236|Gammaproteobacteria,1XMKS@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the RelE toxin family - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_118353_2 232346.JHQL01000001_gene2497 1.16e-41 137.0 COG3609@1|root,COG3609@2|Bacteria,1N9NJ@1224|Proteobacteria,1S9Z4@1236|Gammaproteobacteria,1XMNS@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - - - - - - - - - - ParD_antitoxin k59_118353_3 290398.Csal_0225 1.14e-36 127.0 COG1813@1|root,COG1813@2|Bacteria,1QVBI@1224|Proteobacteria,1SFAQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_31 k59_118353_4 1229205.BUPH_02612 1.99e-235 655.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,2VNYW@28216|Betaproteobacteria,1K78V@119060|Burkholderiaceae 28216|Betaproteobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_118353_5 1168065.DOK_09601 7.6e-254 700.0 COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RPXG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_118353_6 1168065.DOK_09606 3.47e-217 606.0 28HTA@1|root,2Z806@2|Bacteria,1R7QM@1224|Proteobacteria,1RSIK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_118353_7 1449346.JQMO01000003_gene6612 1.01e-21 89.4 2DMB2@1|root,32UGJ@2|Bacteria,2IQ9P@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - Calci_bind_CcbP k59_118353_9 1141663.OOC_04862 6.86e-17 76.6 COG3668@1|root,COG3668@2|Bacteria,1N0WX@1224|Proteobacteria,1S9SM@1236|Gammaproteobacteria,3Z9KN@586|Providencia 1236|Gammaproteobacteria S Belongs to the RelE toxin family - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_118353_10 493475.GARC_3741 2.25e-18 79.7 COG2161@1|root,COG2161@2|Bacteria 2|Bacteria D toxin-antitoxin pair type II binding - - - - - - - - - - - - PhdYeFM_antitox k59_118353_12 1041159.AZUW01000048_gene2435 1.9e-55 189.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,4BAW0@82115|Rhizobiaceae 28211|Alphaproteobacteria L High confidence in function and specificity - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_170289_1 877455.Metbo_1703 4.48e-15 75.5 COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota,23PXP@183925|Methanobacteria 183925|Methanobacteria E SMART ATPase, AAA type, core - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_170289_2 264732.Moth_0928 1.3e-25 103.0 COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,42FT2@68295|Thermoanaerobacterales 186801|Clostridia P PFAM ABC-3 protein - - - ko:K09816,ko:K09819,ko:K19976 ko02010,map02010 M00242,M00243,M00792 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_14229_1 865861.AZSU01000002_gene2724 4.71e-133 396.0 COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,36DK8@31979|Clostridiaceae 186801|Clostridia E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_105132_1 96561.Dole_2113 8.13e-52 177.0 COG0034@1|root,COG0034@2|Bacteria,1R7JX@1224|Proteobacteria,42MAC@68525|delta/epsilon subdivisions,2WKFD@28221|Deltaproteobacteria,2MIUW@213118|Desulfobacterales 28221|Deltaproteobacteria F Glutamine amidotransferase domain - - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7 k59_72728_1 1049564.TevJSym_an00490 1.96e-85 258.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1J4DJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_144339_1 1049564.TevJSym_bq00030 8.98e-78 249.0 COG1385@1|root,COG4660@1|root,COG1385@2|Bacteria,COG4660@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1J5UQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_144339_2 90814.KL370891_gene936 3.21e-24 99.4 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,45ZVS@72273|Thiotrichales 72273|Thiotrichales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_98526_1 1049564.TevJSym_ab01210 2.09e-105 331.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_131338_2 795666.MW7_2628 1.9e-80 252.0 COG1767@1|root,COG1767@2|Bacteria,1NB3R@1224|Proteobacteria,2VJZ4@28216|Betaproteobacteria,1KFZA@119060|Burkholderiaceae 28216|Betaproteobacteria H Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase mdcB - 2.4.2.52 ko:K13930 - - R09675 RC00049,RC00063 ko00000,ko01000 - - - CitG k59_131338_4 1220582.RRU01S_30_00600 4.45e-96 287.0 COG0825@1|root,COG0825@2|Bacteria,1QWH1@1224|Proteobacteria 1224|Proteobacteria I Malonate decarboxylase gamma subunit (MdcE) - - 4.1.1.87 ko:K13933 - - - - ko00000,ko01000 - - - MdcE k59_131338_5 1038862.KB893805_gene3947 1.25e-08 57.8 COG4799@1|root,COG4799@2|Bacteria,1PEAG@1224|Proteobacteria,2TU1H@28211|Alphaproteobacteria,3JWR2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Carboxyl transferase domain mdcD - 2.1.3.10,2.1.3.15,4.1.1.87,6.4.1.3 ko:K01966,ko:K13932,ko:K20510 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.4 - - Carboxyl_trans k59_53298_1 443144.GM21_3075 6.72e-25 97.1 COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria 1224|Proteobacteria L COG2963, Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_40536_1 56780.SYN_00125 1.91e-196 551.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MQ3Y@213462|Syntrophobacterales 28221|Deltaproteobacteria NU PFAM Type II IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_20986_1 339670.Bamb_6611 6.45e-123 378.0 COG3843@1|root,COG3843@2|Bacteria,1QUDG@1224|Proteobacteria,2VNBT@28216|Betaproteobacteria,1K7IC@119060|Burkholderiaceae 28216|Betaproteobacteria U Relaxase mobilization nuclease family protein traI - - - - - - - - - - - Relaxase k59_202562_1 794846.AJQU01000073_gene3913 2.98e-57 192.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,4BA1H@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ Catalyzes the formation of malonyl-CoA from malonate and CoA matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_202562_2 998674.ATTE01000001_gene611 1.98e-35 127.0 COG0454@1|root,COG0456@2|Bacteria,1R407@1224|Proteobacteria,1RPJ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria K histone acetyltransferase HPA2 and related acetyltransferases yiiD GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,YiiD_C k59_202562_3 1049564.TevJSym_ac02110 7.05e-24 94.0 28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,1SEW0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_144344_1 1137799.GZ78_11545 3.53e-74 244.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XIQW@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_46853_1 485913.Krac_10748 9.89e-34 127.0 COG0637@1|root,COG0637@2|Bacteria,2G6ZZ@200795|Chloroflexi 200795|Chloroflexi O TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2,Peptidase_M22 k59_92345_1 1121935.AQXX01000055_gene2915 1.37e-69 217.0 COG5018@1|root,COG5018@2|Bacteria,1RE77@1224|Proteobacteria,1S8NC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Exonuclease - - - - - - - - - - - - RNase_T k59_79622_1 1121342.AUCO01000018_gene990 4.03e-19 87.4 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae 186801|Clostridia L DNA polymerase dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_79622_2 644282.Deba_2372 4.99e-54 183.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_33971_2 1137799.GZ78_12890 1.34e-05 46.2 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XH4P@135619|Oceanospirillales 135619|Oceanospirillales P Phosphate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_124816_1 879212.DespoDRAFT_01479 1.32e-66 215.0 COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_98532_1 706587.Desti_4856 3.41e-40 154.0 COG0457@1|root,COG2114@1|root,COG2888@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG2888@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT Family membership - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12 k59_59903_1 868595.Desca_2508 1.49e-94 288.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,2600A@186807|Peptococcaceae 186801|Clostridia G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_176751_1 1121413.JMKT01000008_gene1650 5.22e-93 281.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M8U2@213115|Desulfovibrionales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_40753_1 1232410.KI421421_gene3825 5.17e-61 214.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_183429_1 1049564.TevJSym_bb00130 8.57e-105 329.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_79777_1 1499967.BAYZ01000016_gene6501 2.71e-202 580.0 COG0296@1|root,COG0296@2|Bacteria 2|Bacteria G 1,4-alpha-glucan branching enzyme activity glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,3.2.1.141,3.2.1.20 ko:K00700,ko:K01187,ko:K01236,ko:K17734 ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110 M00565 R00028,R00801,R00802,R02110,R06087,R06088,R09995,R11256 RC00028,RC00049,RC00077 ko00000,ko00001,ko00002,ko01000,ko01002,ko04147 - CBM48,GH13,GH31 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iJN678.glgB,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Alpha-amylase,Alpha-amylase_C,CBM_48 k59_66396_1 1280950.HJO_09799 2.62e-48 164.0 COG3654@1|root,COG3654@2|Bacteria,1NMI4@1224|Proteobacteria,2UVP2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Fic/DOC family - - - - - - - - - - - - Fic k59_195791_1 1121405.dsmv_3248 2.67e-44 152.0 28PNF@1|root,2ZCB7@2|Bacteria,1RA6N@1224|Proteobacteria,42RBI@68525|delta/epsilon subdivisions,2WN4P@28221|Deltaproteobacteria,2MJHU@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_105308_1 439235.Dalk_5090 1.57e-102 328.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_1480_1 1367847.JCM7686_0843 1.67e-18 89.0 COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2PWHI@265|Paracoccus 28211|Alphaproteobacteria S Protein of unknown function (DUF541) omp28 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K09807 - - - - ko00000 - - - SIMPL k59_202699_1 1379858.N508_02056 5.92e-07 60.1 COG0666@1|root,COG0666@2|Bacteria 2|Bacteria G response to abiotic stimulus - - - - - - - - - - - - Ank,Ank_2,Ank_3,Ank_4 k59_202699_2 1168067.JAGP01000001_gene907 1.44e-125 413.0 COG2203@1|root,COG2206@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG4191@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T domain protein - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_4,PAS_9 k59_176755_1 880072.Desac_0215 5.09e-83 268.0 COG1449@1|root,COG1449@2|Bacteria,1PUYM@1224|Proteobacteria,42MQP@68525|delta/epsilon subdivisions,2WKP2@28221|Deltaproteobacteria,2MQ8B@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - DUF3536,Glyco_hydro_57 k59_131565_1 1232410.KI421415_gene2933 1.94e-102 333.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_98704_1 247490.KSU1_C1386 1.12e-30 120.0 COG1560@1|root,COG1560@2|Bacteria 2|Bacteria M Kdo2-lipid A biosynthetic process - - 2.3.1.241,2.3.1.265 ko:K02517,ko:K20543,ko:K22311 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 1.B.55.3 - - Lip_A_acyltrans,TPR_19 k59_189795_1 216595.PFLU_2518 1.93e-66 227.0 COG4974@1|root,COG4974@2|Bacteria,1MY10@1224|Proteobacteria,1RRQT@1236|Gammaproteobacteria,1YU1B@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - - k59_47048_1 1121405.dsmv_3403 2.68e-59 194.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_47048_2 1121405.dsmv_3404 9.18e-58 193.0 COG1589@1|root,COG1589@2|Bacteria,1RDX7@1224|Proteobacteria,42VCZ@68525|delta/epsilon subdivisions,2WRVM@28221|Deltaproteobacteria,2MKM3@213118|Desulfobacterales 28221|Deltaproteobacteria D Essential cell division protein ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_47048_3 1160707.AJIK01000012_gene123 1.37e-15 75.5 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,26EIE@186818|Planococcaceae 91061|Bacilli M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_34162_1 1121935.AQXX01000102_gene1330 1.09e-87 290.0 COG3451@1|root,COG3451@2|Bacteria,1MUEN@1224|Proteobacteria,1RPAY@1236|Gammaproteobacteria 1236|Gammaproteobacteria U type IV secretory pathway, VirB4 components - - - - - - - - - - - - DUF87,TraC_F_IV k59_183433_1 1049564.TevJSym_am00650 5.78e-250 690.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1J4BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_131567_1 1265505.ATUG01000003_gene622 2.38e-88 295.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_27636_2 706587.Desti_1206 4.19e-57 191.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MQXU@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_202700_2 1118060.CAGZ01000030_gene1133 5.34e-06 51.2 COG1476@1|root,COG1476@2|Bacteria,2I6RE@201174|Actinobacteria,4CV8V@84998|Coriobacteriia 84998|Coriobacteriia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_157252_1 553385.JEMF01000056_gene747 3.35e-110 336.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,1S185@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0685 5,10-methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_79791_1 338963.Pcar_3011 5.04e-43 159.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42NYJ@68525|delta/epsilon subdivisions,2WKWS@28221|Deltaproteobacteria 28221|Deltaproteobacteria GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_92579_1 96561.Dole_0231 9.53e-78 241.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,42QS8@68525|delta/epsilon subdivisions,2WMV7@28221|Deltaproteobacteria,2MJNJ@213118|Desulfobacterales 28221|Deltaproteobacteria S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_85940_1 335543.Sfum_2958 8.91e-150 433.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MRBW@213462|Syntrophobacterales 28221|Deltaproteobacteria F Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_85940_2 933262.AXAM01000034_gene1559 8.37e-20 89.0 COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales 28221|Deltaproteobacteria T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_1486_1 309798.COPRO5265_0180 3.31e-14 73.6 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales 186801|Clostridia C NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding hymB - 1.12.1.3,1.17.1.11,1.6.5.3 ko:K00335,ko:K18331,ko:K22339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_55175_1 335543.Sfum_2508 1.09e-48 170.0 2C2F5@1|root,32WND@2|Bacteria,1ND6R@1224|Proteobacteria,42Q4T@68525|delta/epsilon subdivisions,2WK9F@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_81802_1 395494.Galf_1572 7.03e-177 503.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_43585_1 1117958.PE143B_0107900 5.42e-25 102.0 COG2885@1|root,COG3047@1|root,COG2885@2|Bacteria,COG3047@2|Bacteria,1R8DG@1224|Proteobacteria,1RP3K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,OprF,TSP_3 k59_43585_3 237609.PSAKL28_01250 3.06e-15 86.3 COG0612@1|root,COG0612@2|Bacteria,1QR8N@1224|Proteobacteria,1SRES@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_204668_1 1121033.AUCF01000013_gene1654 2.73e-96 304.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2TTSC@28211|Alphaproteobacteria,2JQZJ@204441|Rhodospirillales 204441|Rhodospirillales K Transcriptional accessory protein - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_159455_1 96561.Dole_1706 2.1e-34 127.0 COG0760@1|root,COG0760@2|Bacteria,1N0CG@1224|Proteobacteria,42SAV@68525|delta/epsilon subdivisions,2WP7E@28221|Deltaproteobacteria,2MKA7@213118|Desulfobacterales 28221|Deltaproteobacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - - - - - - - - - - Rotamase_2,SurA_N_3 k59_62440_1 754436.JCM19237_5134 2.46e-23 102.0 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,1RRE3@1236|Gammaproteobacteria,1Y2PS@135623|Vibrionales 135623|Vibrionales V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_191775_1 635013.TherJR_3012 2.34e-05 47.0 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,260CJ@186807|Peptococcaceae 186801|Clostridia J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_191775_2 177437.HRM2_06660 5.11e-30 118.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria,2MJJC@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM single-stranded nucleic acid binding R3H - - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_121060_3 1541065.JRFE01000017_gene105 2.38e-30 128.0 COG2931@1|root,COG3240@1|root,COG2931@2|Bacteria,COG3240@2|Bacteria,1G66R@1117|Cyanobacteria,3VMF3@52604|Pleurocapsales 1117|Cyanobacteria IQ GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - HemolysinCabind,Lipase_GDSL k59_121060_5 713586.KB900536_gene685 2.27e-21 93.6 COG1989@1|root,COG1989@2|Bacteria,1R34X@1224|Proteobacteria,1SHX5@1236|Gammaproteobacteria 1236|Gammaproteobacteria NOU Type IV leader peptidase family - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 k59_121060_6 713586.KB900536_gene686 1.49e-49 174.0 COG0464@1|root,COG0464@2|Bacteria,1MXFG@1224|Proteobacteria,1RZBX@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ATPase with chaperone activity - - - - - - - - - - - - - k59_179036_1 396588.Tgr7_2465 4.03e-95 285.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_179036_2 768671.ThimaDRAFT_4060 5.97e-192 543.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_179036_3 1049564.TevJSym_bp00170 8.46e-53 171.0 COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein - - - - - - - - - - - - CopD k59_179036_4 1049564.TevJSym_al00680 1.31e-90 272.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1J611@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon narL GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0090352,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903314,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_179036_5 1301098.PKB_0977 4.57e-48 174.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_107584_1 644282.Deba_0111 3.54e-39 144.0 COG0467@1|root,COG0467@2|Bacteria 2|Bacteria T regulation of circadian rhythm - - - - - - - - - - - - AAA_25,MEDS k59_197833_1 1408418.JNJH01000015_gene3245 8.82e-50 166.0 COG5433@1|root,COG5433@2|Bacteria,1PY8T@1224|Proteobacteria,2UGIG@28211|Alphaproteobacteria,2JZ89@204441|Rhodospirillales 204441|Rhodospirillales L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1_assoc k59_74675_1 1049564.TevJSym_bl00220 0.00019 42.7 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_100662_1 439235.Dalk_4515 3.69e-135 403.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_100662_2 439235.Dalk_5241 6.72e-47 153.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,42URZ@68525|delta/epsilon subdivisions,2WQ58@28221|Deltaproteobacteria,2MKGK@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_185770_1 1123274.KB899427_gene3361 1.01e-22 93.6 COG0664@1|root,COG0664@2|Bacteria,2J8WG@203691|Spirochaetes 203691|Spirochaetes T Cyclic nucleotide binding domain protein - - - - - - - - - - - - cNMP_binding k59_152792_1 504472.Slin_0141 1.12e-06 57.8 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_36465_1 1123257.AUFV01000001_gene1720 2.34e-80 292.0 COG0642@1|root,COG4251@1|root,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XD55@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_68856_1 1049564.TevJSym_ap00720 2.28e-76 253.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1J5E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_68856_2 2340.JV46_05950 1.31e-38 132.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1J60X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_146521_2 1405.DJ92_4621 7.6e-45 152.0 COG1670@1|root,COG1670@2|Bacteria,1VDEY@1239|Firmicutes,4IS7T@91061|Bacilli,1ZS22@1386|Bacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_146521_6 1049564.TevJSym_ab00500 1.88e-61 199.0 2E6TU@1|root,331DN@2|Bacteria,1NBK8@1224|Proteobacteria,1SG0X@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_146521_7 765912.Thimo_1646 2.09e-98 294.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales 135613|Chromatiales IQ TIGRFAM acetoacetyl-CoA reductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_146521_10 765913.ThidrDRAFT_0217 1.84e-204 575.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales 135613|Chromatiales I Belongs to the thiolase family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_146521_11 765913.ThidrDRAFT_0216 2.45e-100 307.0 28KIX@1|root,2Z9Y0@2|Bacteria,1R427@1224|Proteobacteria,1RRGI@1236|Gammaproteobacteria,1WX2J@135613|Chromatiales 135613|Chromatiales S TIGRFAM Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - - - - - - - - - - PHA_synth_III_E k59_49224_1 42565.FP66_01330 7.03e-98 297.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XIK3@135619|Oceanospirillales 135619|Oceanospirillales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_159465_1 1049564.TevJSym_bq00010 3.53e-123 379.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J4QC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_55184_2 909663.KI867149_gene3383 8.37e-68 209.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales 28221|Deltaproteobacteria M Large-conductance mechanosensitive channel, MscL mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_133664_1 713586.KB900536_gene1333 3.53e-22 94.4 2EQTE@1|root,33ID4@2|Bacteria,1RKB7@1224|Proteobacteria,1S6DN@1236|Gammaproteobacteria,1WYKP@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_113934_1 1115515.EV102420_07_02780 2.04e-51 169.0 2C1A0@1|root,2ZX64@2|Bacteria,1R39Z@1224|Proteobacteria 1224|Proteobacteria S Type VI secretion system (T6SS), amidase effector protein 4 - - - - - - - - - - - - Tae4 k59_100669_1 1049564.TevJSym_bw00080 2.91e-138 402.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J5FV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_95345_1 335543.Sfum_3911 1.65e-40 150.0 COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase large chain, oligomerisation - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0661 CPSase_L_D2,CPSase_L_D3,MGS k59_172242_1 1158292.JPOE01000002_gene3479 1.45e-68 225.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_28,HTH_29,HTH_33 k59_172242_2 1122135.KB893135_gene1031 5.87e-103 318.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_172242_4 1345695.CLSA_c21720 3.99e-14 79.3 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TSRS@1239|Firmicutes,24BXX@186801|Clostridia,36EKC@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator, arac family - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_172242_6 1117314.PCIT_19729 7.35e-99 301.0 COG4977@1|root,COG4977@2|Bacteria,1RCIG@1224|Proteobacteria,1S2SH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_172242_7 1205680.CAKO01000038_gene1643 2.36e-50 181.0 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,2JW09@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - 1.14.13.235 ko:K22027 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_172242_8 561229.Dd1591_3131 2.42e-34 131.0 COG2175@1|root,COG3207@1|root,COG2175@2|Bacteria,COG3207@2|Bacteria,1RJYX@1224|Proteobacteria,1S7ZT@1236|Gammaproteobacteria,2JD2J@204037|Dickeya 1236|Gammaproteobacteria Q Pyoverdine/dityrosine biosynthesis protein pvcA - - - - - - - - - - - DIT1_PvcA,TauD k59_152795_1 323261.Noc_2139 1.71e-72 233.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X09F@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_139597_1 1487923.DP73_19355 0.000399 50.1 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,261BU@186807|Peptococcaceae 186801|Clostridia V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_114063_1 1123024.AUII01000008_gene1894 1.54e-08 63.5 COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria,4DZIN@85010|Pseudonocardiales 201174|Actinobacteria M Glycosyl transferase 4-like - - - ko:K19424 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_127929_1 243231.GSU0954 4.55e-18 84.0 COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_172371_1 933262.AXAM01000013_gene1325 6.11e-95 291.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MHW6@213118|Desulfobacterales 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_146638_1 203122.Sde_0569 1.2e-305 853.0 COG2730@1|root,COG3507@1|root,COG2730@2|Bacteria,COG3507@2|Bacteria,1R6KS@1224|Proteobacteria 1224|Proteobacteria G CBD_II - - - - - - - - - - - - CBM_2 k59_146638_2 498211.CJA_2959 4.34e-18 96.7 COG2730@1|root,COG2730@2|Bacteria,1R5GC@1224|Proteobacteria,1S10V@1236|Gammaproteobacteria,1FHYB@10|Cellvibrio 1236|Gammaproteobacteria G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Cellulase k59_146638_3 498211.CJA_0045 2.09e-178 523.0 COG3866@1|root,COG3866@2|Bacteria,1QPFF@1224|Proteobacteria,1RY07@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pectate lyase pelB - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C,Pectinesterase k59_146638_4 177437.HRM2_45400 1.26e-25 117.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,42P16@68525|delta/epsilon subdivisions,2WMD4@28221|Deltaproteobacteria,2MPWE@213118|Desulfobacterales 28221|Deltaproteobacteria KL SWIM zinc finger - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_29858_1 552811.Dehly_1516 1.02e-37 145.0 COG2909@1|root,COG2909@2|Bacteria,2G7Q4@200795|Chloroflexi 200795|Chloroflexi K ATP-dependent transcriptional regulator, MalT-like, LuxR family - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_100834_1 1049564.TevJSym_ac01690 5.18e-77 236.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1JA86@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_100834_4 870187.Thini_0860 2.05e-73 230.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,4603R@72273|Thiotrichales 72273|Thiotrichales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_36670_1 1384057.CD33_09025 3.01e-59 198.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,3IWPG@400634|Lysinibacillus 91061|Bacilli E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_43843_1 1121935.AQXX01000140_gene1005 0.0 1122.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RMPX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG2366 Protein related to penicillin acylase aaiD - 3.5.1.97 ko:K07116 - - - - ko00000,ko01000 - - - Penicil_amidase k59_43843_2 1120953.AUBH01000002_gene1534 2.52e-105 320.0 COG0247@1|root,COG0247@2|Bacteria,1R033@1224|Proteobacteria,1T4MK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_139777_1 933262.AXAM01000084_gene1045 2.56e-27 107.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - Glycos_transf_2 k59_139777_2 748449.Halha_1245 2.73e-27 108.0 COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia 186801|Clostridia H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_165825_3 1157638.KB892168_gene6664 2.34e-30 134.0 COG1196@1|root,COG2268@1|root,COG3064@1|root,COG1196@2|Bacteria,COG2268@2|Bacteria,COG3064@2|Bacteria,2I8CG@201174|Actinobacteria 201174|Actinobacteria D DNA-templated transcription, initiation - - - - - - - - - - - - ADPrib_exo_Tox k59_16456_1 113355.CM001775_gene1518 1.33e-30 125.0 COG4467@1|root,COG4467@2|Bacteria,1G4QI@1117|Cyanobacteria 1117|Cyanobacteria L Involved in initiation control of chromosome replication - - - - - - - - - - - - DDE_Tnp_IS66 k59_74894_1 933262.AXAM01000002_gene543 1.19e-93 286.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TraB family protein - - - - - - - - - - - - TraB k59_69078_1 1049564.TevJSym_bc00090 4.42e-120 352.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1J570@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit oadB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_114068_1 1121935.AQXX01000079_gene1542 1.9e-229 655.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,1RQW2@1236|Gammaproteobacteria 1236|Gammaproteobacteria U type IV secretory pathway, VirB4 components trbE - - ko:K20530 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - CagE_TrbE_VirB k59_107832_2 319224.Sputcn32_2653 3.05e-12 75.5 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,2Q900@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4115) rodZ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_107832_3 572477.Alvin_1278 1.56e-45 159.0 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1WWUQ@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - LysM,TPR_10,TPR_14,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_3437_1 1049564.TevJSym_at00080 5.43e-34 130.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_197980_3 396588.Tgr7_0230 2.67e-33 125.0 COG0705@1|root,COG0705@2|Bacteria,1N8NS@1224|Proteobacteria,1SD4M@1236|Gammaproteobacteria,1X1C5@135613|Chromatiales 135613|Chromatiales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_95593_1 349124.Hhal_1527 1.47e-83 273.0 28JFS@1|root,2Z99P@2|Bacteria,1R4G6@1224|Proteobacteria,1RQWK@1236|Gammaproteobacteria,1WX6Y@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_539_2 1232437.KL662058_gene3950 1.93e-07 54.3 COG0745@1|root,COG1148@1|root,COG0745@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MI9Y@213118|Desulfobacterales 28221|Deltaproteobacteria CT NAD(P)-binding Rossmann-like domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg k59_123648_1 1254432.SCE1572_34125 4.25e-48 163.0 COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,437YA@68525|delta/epsilon subdivisions,2X385@28221|Deltaproteobacteria,2YUSI@29|Myxococcales 28221|Deltaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_32869_1 335543.Sfum_1971 2.52e-69 218.0 COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_188486_1 1121405.dsmv_3575 0.000237 42.4 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2WN9B@28221|Deltaproteobacteria,2MIP4@213118|Desulfobacterales 28221|Deltaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_188486_2 1304885.AUEY01000001_gene3234 4.72e-71 216.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2MJZV@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_149636_1 765911.Thivi_2732 1.08e-64 217.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,1WXFW@135613|Chromatiales 135613|Chromatiales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_149636_2 292415.Tbd_1114 4.47e-158 450.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_149636_4 87626.PTD2_15377 1.54e-26 108.0 COG3203@1|root,COG3203@2|Bacteria,1R5CI@1224|Proteobacteria,1RRQI@1236|Gammaproteobacteria,2Q1P0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_7008_1 1123355.JHYO01000009_gene3092 7.16e-11 63.5 COG2703@1|root,COG2703@2|Bacteria,1N8CS@1224|Proteobacteria,2UHH9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_7008_2 1123399.AQVE01000013_gene275 1.1e-219 619.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,1RMJZ@1236|Gammaproteobacteria,460AX@72273|Thiotrichales 72273|Thiotrichales E Serine dehydratase beta chain - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_7008_4 395961.Cyan7425_4301 1.81e-34 148.0 COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3829@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,3KKV1@43988|Cyanothece 1117|Cyanobacteria T SMART PAS domain containing protein - - - - - - - - - - - - GAF,HATPase_c,HisKA_2,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_58864_1 713586.KB900536_gene2651 5.93e-95 287.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1WXT0@135613|Chromatiales 135613|Chromatiales S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_58864_2 1255043.TVNIR_1693 4.76e-55 181.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WW4I@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_13429_1 667014.Thein_2189 3.27e-101 325.0 COG1148@1|root,COG1148@2|Bacteria,2GHRW@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_194894_1 1049564.TevJSym_ag00990 2.16e-10 60.1 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1J4GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_194894_2 765913.ThidrDRAFT_0097 1.43e-42 159.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,1WXFW@135613|Chromatiales 135613|Chromatiales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_156049_2 1121405.dsmv_2774 2.46e-85 271.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_117218_1 237368.SCABRO_02889 1.1e-26 107.0 28PW7@1|root,32EDN@2|Bacteria,2J3ED@203682|Planctomycetes 2|Bacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 k59_194899_2 1049564.TevJSym_au00630 2.89e-33 125.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_194902_1 1047013.AQSP01000122_gene2249 1.02e-120 376.0 28NDD@1|root,2ZBG6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1 k59_71832_1 1049564.TevJSym_aq00390 4.08e-74 230.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1J52T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_26488_1 335543.Sfum_3614 4.11e-48 171.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CFM@68525|delta/epsilon subdivisions,2X7QN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_58899_1 1144343.PMI41_00024 1.69e-34 125.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,43GUX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_58899_2 231434.JQJH01000027_gene1584 1.16e-62 211.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N9VZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase type 2 domain - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_143065_1 96561.Dole_2808 1.21e-70 232.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2X72U@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_547_1 1049564.TevJSym_cx00010 5.81e-126 384.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_104186_1 1121405.dsmv_3564 1.61e-158 451.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MI89@213118|Desulfobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_175487_1 1278073.MYSTI_01933 7.03e-66 224.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,42MCU@68525|delta/epsilon subdivisions,2WJ3Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_136649_1 1232410.KI421422_gene2016 1.09e-70 236.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,43S7U@69541|Desulfuromonadales 28221|Deltaproteobacteria M Transglycosylase mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_194903_1 1122201.AUAZ01000004_gene3448 7.63e-86 264.0 2DB8P@1|root,2Z7SB@2|Bacteria,1R765@1224|Proteobacteria,1SIAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_194903_2 1121935.AQXX01000096_gene2562 4.86e-78 247.0 COG0745@1|root,COG0745@2|Bacteria,1QZ0B@1224|Proteobacteria 1224|Proteobacteria KT RESPONSE REGULATOR receiver - - - - - - - - - - - - - k59_123659_1 572477.Alvin_0409 1.16e-144 419.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_39370_1 1049564.TevJSym_as00390 9.29e-45 156.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1J4I5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component gtrB - - - - - - - - - - - DctM k59_39370_2 1049564.TevJSym_as00400 2.1e-75 230.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1J63A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q transport system, small permease component gtrA - - - - - - - - - - - DctQ k59_39370_4 1049564.TevJSym_as00420 1.05e-145 413.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1J5SE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_39370_5 1049564.TevJSym_as00440 5.99e-205 585.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_65339_1 105559.Nwat_2914 2.14e-32 128.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales 135613|Chromatiales P heavy metal translocating P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_175491_1 314345.SPV1_12360 5.4e-201 567.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_175492_1 335543.Sfum_3479 1.11e-68 237.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MQ8P@213462|Syntrophobacterales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_156060_1 391615.ABSJ01000017_gene1628 9.69e-160 466.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1J571@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345 SBP_bac_3,SLT k59_45863_1 1049564.TevJSym_an00340 1.11e-11 61.6 2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_45863_2 2340.JV46_25180 1.37e-43 150.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1J4E7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 SAICAR_synt k59_7046_1 1049564.TevJSym_aa00860 3.43e-94 279.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1J4E4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D cell division ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_7046_2 1249627.D779_0976 6.82e-155 448.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_7046_3 1049564.TevJSym_aa00880 3.6e-210 593.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1JC0J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_7046_5 435908.IDSA_06495 1.35e-05 46.6 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,2QG43@267893|Idiomarinaceae 1236|Gammaproteobacteria J Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_52361_2 583355.Caka_0770 7.74e-157 454.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_1,Glycos_transf_2 k59_13444_1 1458427.BAWN01000011_gene686 4.35e-42 147.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,4AB1C@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_5 cbbQ - 6.6.1.2 ko:K04748,ko:K09882 ko00860,ko01100,map00860,map01100 - R00294,R05227 RC02000,RC02794 ko00000,ko00001,ko01000 3.D.4.10 - - AAA_5,CbbQ_C k59_13444_5 1049564.TevJSym_ag00620 6.54e-44 147.0 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1SBVN@1236|Gammaproteobacteria,1JBWS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bacterial DNA-binding protein hup - - - - - - - - - - - Bac_DNA_binding k59_13444_6 1278073.MYSTI_05438 2.25e-34 127.0 2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,42TNH@68525|delta/epsilon subdivisions,2WQ32@28221|Deltaproteobacteria,2YVZS@29|Myxococcales 28221|Deltaproteobacteria S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_13444_7 1049564.TevJSym_ag00600 7.17e-176 525.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_45870_1 706587.Desti_0788 1.42e-17 86.3 2EZCD@1|root,33SHS@2|Bacteria,1NSZK@1224|Proteobacteria,42Z6T@68525|delta/epsilon subdivisions,2WTZ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_32903_1 1207076.ALAT01000187_gene2802 3.62e-10 60.1 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1Z103@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S COG0714 MoxR-like ATPases - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_32903_2 1163407.UU7_00020 1.74e-16 82.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria,1X3P2@135614|Xanthomonadales 135614|Xanthomonadales S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_182047_1 269799.Gmet_2200 1.2e-16 83.2 COG0491@1|root,COG0491@2|Bacteria,1RB5G@1224|Proteobacteria,42QQ5@68525|delta/epsilon subdivisions,2WN4G@28221|Deltaproteobacteria 28221|Deltaproteobacteria S beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_136653_3 1123242.JH636434_gene4864 2.42e-29 117.0 COG4123@1|root,COG4123@2|Bacteria 2|Bacteria AJ Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - - - - - - - - - - Methyltransf_25 k59_58909_1 665571.STHERM_c14100 3.02e-90 280.0 COG0232@1|root,COG0232@2|Bacteria,2J69E@203691|Spirochaetes 203691|Spirochaetes F PFAM Metal-dependent phosphohydrolase, HD dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_188511_1 216595.PFLU_4585 1.64e-21 102.0 COG0210@1|root,COG0210@2|Bacteria 2|Bacteria L ATP-dependent DNA helicase activity lidB - - - - - - - - - - - AAA_11,AAA_12,AAA_19,AAA_30,DUF559,HRDC,NERD,PDDEXK_1 k59_32906_1 1121396.KB892990_gene4477 7.63e-78 258.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MIZ0@213118|Desulfobacterales 28221|Deltaproteobacteria GT PEP-utilising enzyme, mobile domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_52366_1 1049564.TevJSym_au00510 6.14e-142 411.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1J4TX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_117242_1 1049564.TevJSym_cx00010 3.91e-46 165.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_39388_1 933262.AXAM01000002_gene503 8.47e-89 277.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales 28221|Deltaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_201743_2 1049564.TevJSym_au00240 8.87e-182 520.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1J4Y1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_65527_1 485915.Dret_2002 8.83e-116 344.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_26677_1 1248232.BANQ01000088_gene2625 5e-29 112.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1XU78@135623|Vibrionales 135623|Vibrionales H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_26677_2 933262.AXAM01000016_gene154 2.32e-29 108.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MM4E@213118|Desulfobacterales 28221|Deltaproteobacteria L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_104366_1 1265505.ATUG01000003_gene578 7.06e-95 283.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,rve k59_195076_3 2340.JV46_17100 0.0 1138.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1J4W4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_113054_2 1278309.KB907099_gene2933 9.87e-160 464.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_5,Pyr_redox_3 k59_164793_2 941449.dsx2_0364 4.61e-82 261.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_61297_1 1121912.AUHD01000026_gene310 7.58e-49 177.0 COG3344@1|root,COG3344@2|Bacteria,4NHMS@976|Bacteroidetes,1HZPH@117743|Flavobacteriia 976|Bacteroidetes L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_106520_1 1121405.dsmv_0106 1.39e-62 196.0 COG3005@1|root,COG3005@2|Bacteria,1RIC0@1224|Proteobacteria,42NW0@68525|delta/epsilon subdivisions,2WK0R@28221|Deltaproteobacteria,2MJCY@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM NapC NirT cytochrome c - - - ko:K02569,ko:K03532 ko02020,map02020 - - - ko00000,ko00001,ko02000 5.A.3.4 - - Cytochrom_NNT k59_73844_1 63737.Npun_R1245 3.32e-47 155.0 2D8VC@1|root,32TS1@2|Bacteria,1G8H1@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_54495_1 743721.Psesu_1701 3.94e-50 183.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X3RD@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase rpfC - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_113060_1 323850.Shew_0041 8.64e-06 53.5 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8QJ@267890|Shewanellaceae 1236|Gammaproteobacteria T SMART PAS domain containing protein - - - - - - - - - - - - CBS,EAL,GGDEF,HAMP,NIT,PAS,PAS_4,PAS_9 k59_184723_1 304371.MCP_1179 4.97e-63 214.0 COG0642@1|root,COG2202@1|root,arCOG02350@1|root,arCOG02350@2157|Archaea,arCOG06192@2157|Archaea,arCOG06515@2157|Archaea 2157|Archaea T Contains one ATP-binding region, ATPase-like domain (IPR003594) - - - - - - - - - - - - GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_9 k59_94106_1 335283.Neut_1576 1.48e-118 350.0 COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,2VNRX@28216|Betaproteobacteria,371QM@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF3463) hpnH - - - - - - - - - - - DUF3463,Fer4_14,Radical_SAM k59_151996_1 1121405.dsmv_2851 5.11e-31 128.0 COG0642@1|root,COG2205@2|Bacteria,1R5AX@1224|Proteobacteria,43DEA@68525|delta/epsilon subdivisions,2WJHY@28221|Deltaproteobacteria,2MJDF@213118|Desulfobacterales 28221|Deltaproteobacteria T GAF domain - - - - - - - - - - - - HATPase_c,PAS k59_203791_1 880072.Desac_0497 1.34e-40 134.0 2FJKA@1|root,34B9P@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_9438_1 1282356.H045_18535 1.51e-44 162.0 COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,1RQRZ@1236|Gammaproteobacteria,1YMC2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria V Inner membrane protein CreD creD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06143 - - - - ko00000 - - - CreD k59_9438_3 1112274.KI911560_gene2426 6.95e-96 332.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,2KNRT@206350|Nitrosomonadales 206350|Nitrosomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,Response_reg k59_106529_1 338963.Pcar_1385 3.05e-65 210.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_48252_1 1049564.TevJSym_bk00230 1.2e-169 491.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_9439_1 933262.AXAM01000077_gene1703 1.23e-70 227.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_126539_1 1279019.ARQK01000042_gene2007 6.03e-39 137.0 COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,1S5YE@1236|Gammaproteobacteria,1WYIG@135613|Chromatiales 135613|Chromatiales N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation - - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_190981_1 1034347.CAHJ01000069_gene2678 4e-20 91.3 COG3449@1|root,COG3449@2|Bacteria,1V73Y@1239|Firmicutes,4HH9C@91061|Bacilli,1ZG5N@1386|Bacillus 91061|Bacilli L Bacterial transcription activator, effector binding domain yosT - - - - - - - - - - - GyrI-like k59_106532_1 1121406.JAEX01000005_gene3049 1.56e-24 102.0 COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,42N9B@68525|delta/epsilon subdivisions,2WIYW@28221|Deltaproteobacteria,2M9VH@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM polar amino acid ABC transporter, inner membrane subunit - - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1,SBP_bac_3 k59_94115_1 883.DvMF_1730 6.14e-09 59.3 COG0745@1|root,COG3852@1|root,COG0745@2|Bacteria,COG3852@2|Bacteria,1R50S@1224|Proteobacteria,42NWW@68525|delta/epsilon subdivisions,2WMKY@28221|Deltaproteobacteria,2MH9F@213115|Desulfovibrionales 28221|Deltaproteobacteria T PAS fold - - - - - - - - - - - - HisKA,PAS_3,Response_reg k59_152000_1 933262.AXAM01000002_gene526 7.24e-26 109.0 COG0768@1|root,COG0768@2|Bacteria,1R7A0@1224|Proteobacteria,42MJC@68525|delta/epsilon subdivisions,2WJZ2@28221|Deltaproteobacteria,2MJ2J@213118|Desulfobacterales 28221|Deltaproteobacteria M Penicillin-binding Protein pbp4 - - - - - - - - - - - Transpeptidase k59_152000_2 264732.Moth_0048 4.44e-10 60.5 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,42EPT@68295|Thermoanaerobacterales 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_61316_1 933262.AXAM01000015_gene69 1.21e-98 289.0 COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,42M21@68525|delta/epsilon subdivisions,2WK4G@28221|Deltaproteobacteria,2MKV8@213118|Desulfobacterales 28221|Deltaproteobacteria S DJ-1/PfpI family - - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_171615_1 439235.Dalk_4245 1.14e-27 112.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2WKJ1@28221|Deltaproteobacteria,2MIY8@213118|Desulfobacterales 28221|Deltaproteobacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF,HD,HD_5 k59_171615_2 696369.KI912183_gene2695 4.92e-06 48.5 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,2612F@186807|Peptococcaceae 186801|Clostridia HP TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_42299_1 1340493.JNIF01000004_gene1116 3.46e-19 82.8 2E7HP@1|root,33206@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1475) - - - - - - - - - - - - DUF1475 k59_42299_2 1499967.BAYZ01000048_gene2696 1.32e-56 187.0 COG2230@1|root,COG2230@2|Bacteria 2|Bacteria M cyclopropane-fatty-acyl-phospholipid synthase cfa - 2.1.1.317,2.1.1.79 ko:K00574,ko:K20238 - - - - ko00000,ko01000 - - iJN746.PP_2734 CMAS k59_145626_2 666681.M301_1848 2.15e-57 189.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,2KKW1@206350|Nitrosomonadales 206350|Nitrosomonadales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_145626_3 314345.SPV1_13177 4.34e-46 160.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria 1224|Proteobacteria M mechanosensitive ion channel ynaI - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_73852_2 41431.PCC8801_2603 1.94e-10 58.2 COG1942@1|root,COG1942@2|Bacteria,1G6RE@1117|Cyanobacteria,3KI6S@43988|Cyanothece 1117|Cyanobacteria S PFAM macrophage migration inhibitory factor family protein - - - - - - - - - - - - MIF k59_9442_1 1301098.PKB_3379 2.47e-80 261.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_178118_2 879212.DespoDRAFT_02386 9.93e-23 99.4 COG2357@1|root,COG2357@2|Bacteria,1RCHE@1224|Proteobacteria,42PPK@68525|delta/epsilon subdivisions,2WJBS@28221|Deltaproteobacteria,2MHSG@213118|Desulfobacterales 28221|Deltaproteobacteria S Region found in RelA / SpoT proteins - - - - - - - - - - - - RelA_SpoT k59_22536_1 59196.RICGR_1450 1.08e-05 52.4 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_22536_2 1049564.TevJSym_ad00950 5.5e-230 645.0 COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,1RM7P@1236|Gammaproteobacteria,1J5CP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0032787,GO:0034641,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046177,GO:0046395,GO:0046483,GO:0046496,GO:0046983,GO:0051156,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072329,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - iECS88_1305.ECS88_2128,iECW_1372.ECW_m2189,iEKO11_1354.EKO11_1765,iPC815.YPO1541,iWFL_1372.ECW_m2189 6PGD,NAD_binding_2 k59_126548_1 439235.Dalk_4262 5.05e-56 199.0 COG0664@1|root,COG1033@1|root,COG2199@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,COG3706@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - GGDEF,LolA_like,MMPL,cNMP_binding k59_132834_1 335543.Sfum_0609 1.13e-54 177.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria 28221|Deltaproteobacteria C iron-sulfur binding qrcC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7 k59_73854_1 1348635.BBJY01000001_gene2394 1.13e-87 280.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1XWJ5@135623|Vibrionales 135623|Vibrionales P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_42497_1 187272.Mlg_0530 3.06e-12 67.8 COG3063@1|root,COG3271@1|root,COG3063@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1X0UF@135613|Chromatiales 135613|Chromatiales NU Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16 k59_81051_1 395493.BegalDRAFT_1633 3.36e-32 124.0 COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,1RQC1@1236|Gammaproteobacteria,4629S@72273|Thiotrichales 72273|Thiotrichales S PFAM GHMP kinases C terminal - - - - - - - - - - - - GHMP_kinases_C,GHMP_kinases_N k59_81051_2 765913.ThidrDRAFT_0563 1.6e-12 65.9 COG1748@1|root,COG1748@2|Bacteria,1QZYP@1224|Proteobacteria 1224|Proteobacteria C PFAM Methylene-tetrahydromethanopterin dehydrogenase - - - ko:K10714 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R08059 RC00202 ko00000,ko00001,ko01000 - - - Mpt_N k59_67976_1 1049564.TevJSym_az00090 5.28e-10 58.5 COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,1RQIT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P reductase nrfD - - ko:K04015 - - - - ko00000 - - - NrfD k59_67976_2 1049564.TevJSym_az00080 1.98e-140 397.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1RPUU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Tetrathionate reductase, subunit B ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_15489_1 765911.Thivi_1977 6.4e-34 127.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_15489_2 1134474.O59_000231 5.5e-48 162.0 2EE3B@1|root,337XX@2|Bacteria,1P6PP@1224|Proteobacteria,1SVF5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_15489_3 208439.AJAP_24030 1.87e-51 178.0 COG0697@1|root,COG0697@2|Bacteria,2GP9G@201174|Actinobacteria,4E08P@85010|Pseudonocardiales 201174|Actinobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_15489_4 349521.HCH_02792 3.15e-75 239.0 COG0436@1|root,COG0436@2|Bacteria,1QG11@1224|Proteobacteria,1SMUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_197110_1 317013.NY99_18465 2.32e-31 125.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1X381@135614|Xanthomonadales 135614|Xanthomonadales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_197110_2 754477.Q7C_153 3.36e-142 409.0 COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,46253@72273|Thiotrichales 72273|Thiotrichales S Hydrolase, carbon-nitrogen family - - - - - - - - - - - - CN_hydrolase k59_197110_3 400668.Mmwyl1_3132 6.45e-93 278.0 COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,1S225@1236|Gammaproteobacteria,1XK98@135619|Oceanospirillales 135619|Oceanospirillales K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_197110_4 2340.JV46_16710 4.75e-17 78.6 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1J5FZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_191173_1 1121920.AUAU01000011_gene175 8.05e-32 121.0 COG0345@1|root,COG0345@2|Bacteria,3Y41B@57723|Acidobacteria 57723|Acidobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_145798_1 335543.Sfum_3475 1.08e-93 296.0 COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MRDF@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Radical SAM - - - - - - - - - - - - Radical_SAM k59_132969_2 1379281.AVAG01000054_gene557 4.45e-54 181.0 COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,42NWK@68525|delta/epsilon subdivisions,2WM2T@28221|Deltaproteobacteria,2MEGC@213115|Desulfovibrionales 28221|Deltaproteobacteria I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 k59_184911_2 207954.MED92_03348 2.17e-58 195.0 COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,1S2ZY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM HupH hydrogenase expression protein, C-terminal conserved region hyaF - - ko:K03618 - - - - ko00000 - - - HupH_C,Rubredoxin k59_184911_3 670307.HYPDE_28318 8.44e-39 130.0 COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria 1224|Proteobacteria C Belongs to the rubredoxin family hupI - - - - - - - - - - - Rubredoxin k59_203959_2 1121468.AUBR01000012_gene2604 5.48e-50 163.0 2F79F@1|root,33ZQP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_22674_2 1187848.AJYQ01000025_gene1548 8.97e-116 339.0 COG0477@1|root,COG2814@2|Bacteria,1N0D0@1224|Proteobacteria,1RZPK@1236|Gammaproteobacteria,1Y0I9@135623|Vibrionales 135623|Vibrionales EGP Necrosis inducing protein (NPP1) - - - - - - - - - - - - NPP1 k59_22674_3 870187.Thini_4237 5.08e-131 380.0 COG2253@1|root,COG2253@2|Bacteria,1R3R3@1224|Proteobacteria,1S0PT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_22674_4 879212.DespoDRAFT_01638 8.24e-70 219.0 COG5340@1|root,COG5340@2|Bacteria,1RGNP@1224|Proteobacteria,42UD1@68525|delta/epsilon subdivisions,2WQPR@28221|Deltaproteobacteria,2MM9V@213118|Desulfobacterales 28221|Deltaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_22674_5 590409.Dd586_0395 5.64e-35 121.0 2EI6M@1|root,33BXY@2|Bacteria,1NGAW@1224|Proteobacteria,1SR4B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_22674_6 1163407.UU7_00650 4.77e-17 78.6 COG0732@1|root,COG0732@2|Bacteria,1NFDW@1224|Proteobacteria,1SZZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity - - - - - - - - - - - - Methylase_S k59_67981_1 335543.Sfum_2525 1.53e-104 317.0 COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MQYD@213462|Syntrophobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_74004_1 1049564.TevJSym_ac01050 4.55e-104 317.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1J4P5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcSMS35_1347.EcSMS35_4486 PGI k59_2670_2 335543.Sfum_1286 8.26e-85 271.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MRB1@213462|Syntrophobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit qmoB - - ko:K16886 - - - - ko00000 - - - Fer4,Fer4_9,FlpD,Pyr_redox_2 k59_152177_1 1121946.AUAX01000020_gene3083 1.09e-36 139.0 COG3266@1|root,COG5297@1|root,COG3266@2|Bacteria,COG5297@2|Bacteria,2GM06@201174|Actinobacteria,4DBIV@85008|Micromonosporales 201174|Actinobacteria G domain, Protein - - - - - - - - - - - - CBM_2 k59_145804_1 335543.Sfum_3923 1.98e-110 340.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MRI6@213462|Syntrophobacterales 28221|Deltaproteobacteria MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_42518_1 1517682.HW49_02120 2.22e-44 165.0 28MSN@1|root,2ZB0Y@2|Bacteria,4NHW7@976|Bacteroidetes,2FX00@200643|Bacteroidia,22ZC2@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - VIT k59_74006_2 292415.Tbd_2597 1.62e-23 101.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,1KT2F@119069|Hydrogenophilales 119069|Hydrogenophilales I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_148155_1 335543.Sfum_1605 2.35e-92 275.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MQSN@213462|Syntrophobacterales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_115498_1 2340.JV46_03580 2e-81 260.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_12185_1 335543.Sfum_1925 1.52e-35 141.0 COG0699@1|root,COG0699@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MRED@213462|Syntrophobacterales 28221|Deltaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_135232_1 1232410.KI421425_gene1553 2.86e-112 347.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_199446_1 644968.DFW101_2946 2.14e-70 229.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria,2MASN@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_7,rve k59_97142_3 1123504.JQKD01000103_gene2971 3.05e-22 95.9 COG0175@1|root,COG0175@2|Bacteria,1MXND@1224|Proteobacteria,2W1SA@28216|Betaproteobacteria 28216|Betaproteobacteria EH sulfate reduction - - - - - - - - - - - - - k59_193235_1 335543.Sfum_1529 1.52e-21 94.0 COG0025@1|root,COG0025@2|Bacteria,1REWR@1224|Proteobacteria,437JE@68525|delta/epsilon subdivisions,2X2TE@28221|Deltaproteobacteria,2MQZ0@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_193235_2 1410676.JNKL01000051_gene142 1.11e-24 97.1 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1Y4GR@135624|Aeromonadales 135624|Aeromonadales J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_38333_1 748247.AZKH_p0046 1.56e-33 124.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales 206389|Rhodocyclales P COG0798 Arsenite efflux pump ACR3 and related permeases arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_38333_3 1123261.AXDW01000007_gene2174 6.9e-31 136.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales 135614|Xanthomonadales U AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_141434_1 384765.SIAM614_24032 2.93e-07 52.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_141434_2 1049564.TevJSym_bb00240 9.6e-96 291.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1J4PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_187554_1 1049564.TevJSym_au00630 1.49e-122 360.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_51211_1 756272.Plabr_3860 2.86e-19 88.6 COG3119@1|root,COG3119@2|Bacteria,2IX0Y@203682|Planctomycetes 203682|Planctomycetes P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_4909_1 439235.Dalk_0403 1.21e-22 96.7 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_4909_2 1121405.dsmv_0942 7.19e-27 103.0 COG5663@1|root,COG5663@2|Bacteria,1MZTH@1224|Proteobacteria,42TWZ@68525|delta/epsilon subdivisions,2WQEQ@28221|Deltaproteobacteria,2MK8P@213118|Desulfobacterales 28221|Deltaproteobacteria S 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - ko:K05967 - - - - ko00000 - - - NT5C k59_64256_1 335543.Sfum_2651 6.28e-89 276.0 28KCD@1|root,2Z9ZC@2|Bacteria,1PQQ5@1224|Proteobacteria,42MA9@68525|delta/epsilon subdivisions,2WJX2@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Diadenylate cyclase - - - - - - - - - - - - DisA_N k59_64256_2 996637.SGM_2070 0.000904 44.3 COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family echA17 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_115756_1 96561.Dole_1719 2.4e-11 69.7 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_56778_1 472759.Nhal_1896 4.6e-265 863.0 COG3209@1|root,COG3292@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3292@2|Bacteria,COG3391@2|Bacteria,1MVV1@1224|Proteobacteria,1RY7B@1236|Gammaproteobacteria,1X2AS@135613|Chromatiales 135613|Chromatiales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - NHL,RHS_repeat k59_102503_1 857087.Metme_3218 1.48e-72 228.0 COG0540@1|root,COG0540@2|Bacteria,1R3Q5@1224|Proteobacteria,1RYCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family - - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_102503_3 857087.Metme_3216 1.51e-121 361.0 COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_187776_3 688270.Celal_0682 2.83e-64 199.0 2DPS7@1|root,3335T@2|Bacteria,4NV9V@976|Bacteroidetes,1I5TH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - Tox-MPTase3 k59_71009_1 1049564.TevJSym_ap00050 1.98e-70 236.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_187778_1 234267.Acid_3175 1.08e-21 100.0 COG1075@1|root,COG1404@1|root,COG1075@2|Bacteria,COG1404@2|Bacteria,3Y2EZ@57723|Acidobacteria 2|Bacteria O Beta-propeller repeat - - - - - - - - - - - - SBBP k59_56785_1 118168.MC7420_3893 4.7e-05 50.1 COG0607@1|root,COG0607@2|Bacteria,1G56U@1117|Cyanobacteria,1HB8T@1150|Oscillatoriales 1117|Cyanobacteria P Rhodanese-related sulfurtransferase - - - - - - - - - - - - DUF2892,Rhodanese k59_199675_1 1123228.AUIH01000091_gene569 1.34e-68 232.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_56789_1 1121405.dsmv_3271 6.97e-65 213.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2WIWY@28221|Deltaproteobacteria,2MHR1@213118|Desulfobacterales 28221|Deltaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_206318_1 272134.KB731324_gene2968 1.99e-07 50.1 COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1HBDB@1150|Oscillatoriales 1117|Cyanobacteria O PFAM FKBP-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_25436_1 1278309.KB907103_gene1023 8.58e-52 193.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1XIKY@135619|Oceanospirillales 135619|Oceanospirillales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_71019_1 926550.CLDAP_09130 3.36e-20 87.8 COG5485@1|root,COG5485@2|Bacteria 2|Bacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL,SnoaL_2 k59_56792_1 1121456.ATVA01000011_gene1701 2.1e-57 199.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2M7SH@213115|Desulfovibrionales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,Voltage_CLC k59_115774_1 1265505.ATUG01000001_gene4074 4.57e-49 158.0 2DP9Z@1|root,3316S@2|Bacteria,1R1CI@1224|Proteobacteria,42V8N@68525|delta/epsilon subdivisions,2X8FK@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_115774_3 555779.Dthio_PD1183 8.73e-07 48.1 2EMW4@1|root,33FIC@2|Bacteria,1NNFE@1224|Proteobacteria,42XUZ@68525|delta/epsilon subdivisions,2WSVM@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_71023_1 1249627.D779_2905 1.11e-82 259.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWTP@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K10126,ko:K10943 ko02020,ko05111,map02020,map05111 M00504,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_51238_1 1049564.TevJSym_bu00050 5.07e-161 489.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_161386_1 1049564.TevJSym_ah00850 4.19e-21 100.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_83467_2 870187.Thini_3231 1.12e-24 102.0 COG0425@1|root,COG2334@1|root,COG0425@2|Bacteria,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,1RPR6@1236|Gammaproteobacteria,460A9@72273|Thiotrichales 72273|Thiotrichales F Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH,TusA k59_12372_10 697281.Mahau_1571 9.03e-23 111.0 COG2604@1|root,COG2604@2|Bacteria,1U2BC@1239|Firmicutes,24CSU@186801|Clostridia,42F4U@68295|Thermoanaerobacterales 186801|Clostridia S Protein of unknown function DUF115 - - - - - - - - - - - - MAF_flag10 k59_12372_11 1327990.S0A059_9CAUD 1.37e-57 193.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_56797_1 1150864.MILUP08_44600 1.16e-90 276.0 2EQPF@1|root,33I9D@2|Bacteria,2IC8C@201174|Actinobacteria,4DCKT@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_89811_2 1049564.TevJSym_ao00770 1.68e-100 301.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S4VY@1236|Gammaproteobacteria,1JAMV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_4930_1 96561.Dole_3001 1.4e-29 115.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,42QTW@68525|delta/epsilon subdivisions,2WMNU@28221|Deltaproteobacteria,2MJYF@213118|Desulfobacterales 28221|Deltaproteobacteria G Major Facilitator Superfamily - - - ko:K02445 - - - - ko00000,ko02000 2.A.1.4.3 - - MFS_1 k59_4930_2 1121405.dsmv_2195 1.91e-74 239.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_102525_1 933262.AXAM01000048_gene2589 6.99e-108 323.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria,2MIFC@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_193462_1 1049564.TevJSym_bc00080 1.62e-143 421.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1J4MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CI COG5016 Pyruvate oxaloacetate carboxyltransferase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_56801_2 1049564.TevJSym_ar00190 2.85e-118 348.0 COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1J5PN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator cmpR_1 - - - - - - - - - - - HTH_1,LysR_substrate k59_18148_1 452637.Oter_3802 2.63e-165 494.0 COG0841@1|root,COG0841@2|Bacteria,46SDW@74201|Verrucomicrobia,3K7E7@414999|Opitutae 414999|Opitutae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_71045_1 706587.Desti_0497 1.76e-53 182.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_18154_1 1232437.KL662025_gene932 8.23e-97 293.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2MHP8@213118|Desulfobacterales 28221|Deltaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_161404_1 663278.Ethha_2483 0.000582 47.4 COG0790@1|root,COG0790@2|Bacteria,1TS5X@1239|Firmicutes,248TS@186801|Clostridia,3WIZE@541000|Ruminococcaceae 186801|Clostridia L Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_135492_1 420324.KI912087_gene7240 6.92e-33 117.0 2APA5@1|root,31EC7@2|Bacteria,1RHMQ@1224|Proteobacteria,2UAKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_135492_2 484022.Fphi_1734 1.88e-69 227.0 2EYC8@1|root,33RKK@2|Bacteria,1NSXD@1224|Proteobacteria,1SMJE@1236|Gammaproteobacteria,461TA@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_98903_1 635013.TherJR_2237 9.98e-16 73.9 COG2005@1|root,COG2005@2|Bacteria 2|Bacteria P Transcriptional regulator - - - ko:K02019,ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000,ko03000 3.A.1.6.2,3.A.1.6.4 - - HTH_1,PBP_like_2 k59_131804_1 35703.DQ02_10400 6.15e-78 245.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,3WXNW@544|Citrobacter 1236|Gammaproteobacteria O Peptidase family U32 C-terminal domain yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_79930_1 335543.Sfum_1328 1.46e-77 244.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,43A0M@68525|delta/epsilon subdivisions,2X9UN@28221|Deltaproteobacteria,2MS7U@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red k59_1665_1 28229.ND2E_1268 1.48e-94 288.0 COG1575@1|root,COG1575@2|Bacteria,1QHA9@1224|Proteobacteria,1TEVV@1236|Gammaproteobacteria,2Q7F8@267889|Colwelliaceae 1236|Gammaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_202891_2 701347.Entcl_4318 2.19e-42 163.0 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - Flg_new,LRR_5,PKD k59_105517_1 243233.MCA1492 2.41e-25 108.0 COG3119@1|root,COG3119@2|Bacteria,1QXQ0@1224|Proteobacteria,1T00D@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Tat (Twin-arginine translocation) pathway signal sequence domain protein - - - - - - - - - - - - HXXSHH k59_105517_2 1453501.JELR01000005_gene1677 4.89e-66 233.0 COG2010@1|root,COG2133@1|root,COG2730@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,COG2730@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,465UX@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,Cytochrome_CBB3,GSDH,PSCyt3,PSD3,PSD4,PSD5,SGL k59_137786_1 706587.Desti_0048 1.18e-14 78.6 COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase, HAMP - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_21538_2 472759.Nhal_0529 4.7e-74 227.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_144760_1 455436.DS989811_gene1761 0.0 965.0 COG2801@1|root,COG2801@2|Bacteria,1PDVT@1224|Proteobacteria,1RQCZ@1236|Gammaproteobacteria,468N5@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives tnsB - - - - - - - - - - - Mu-transpos_C,rve k59_144760_2 675813.VIB_002051 5.99e-113 343.0 COG2842@1|root,COG2842@2|Bacteria,1MV76@1224|Proteobacteria,1RPTQ@1236|Gammaproteobacteria,1XTBE@135623|Vibrionales 135623|Vibrionales S Bacterial TniB protein - - - - - - - - - - - - AAA_22 k59_138013_2 713587.THITH_17030 2.53e-34 131.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales 135613|Chromatiales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_177321_1 637389.Acaty_c0661 1.38e-105 323.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,2NDQG@225057|Acidithiobacillales 225057|Acidithiobacillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_1872_1 335543.Sfum_1239 5.72e-60 202.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MR54@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_157722_1 99598.Cal7507_3738 2.1e-191 588.0 COG3299@1|root,COG3299@2|Bacteria,1G6U3@1117|Cyanobacteria 1117|Cyanobacteria T protein, phage tail-like region - - - - - - - - - - - - Baseplate_J,Sortilin-Vps10 k59_73269_1 1095750.HMPREF9970_2369 1.06e-18 89.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,1HVGQ@1164882|Lachnoanaerobaculum 186801|Clostridia P Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_66885_4 323848.Nmul_A1955 2.3e-09 57.0 COG0226@1|root,COG0226@2|Bacteria,1N19C@1224|Proteobacteria,2VWK2@28216|Betaproteobacteria,3735X@32003|Nitrosomonadales 28216|Betaproteobacteria P COG0226 ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_28107_1 1049564.TevJSym_ac00720 1.45e-23 94.0 COG2882@1|root,COG2882@2|Bacteria,1PUI7@1224|Proteobacteria,1TAJY@1236|Gammaproteobacteria,1J75K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NOU Flagellar FliJ protein - - - - - - - - - - - - FliJ k59_28107_4 1122201.AUAZ01000005_gene557 4.51e-92 278.0 COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,1S22Y@1236|Gammaproteobacteria,4657A@72275|Alteromonadaceae 1236|Gammaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26 k59_28107_5 1049564.TevJSym_bi00070 4.29e-87 263.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria 1224|Proteobacteria C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine nrdG - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_28107_6 1188256.BASI01000002_gene3083 1.95e-15 70.1 COG1328@1|root,COG1328@2|Bacteria,1N8MB@1224|Proteobacteria,2UFHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Anaerobic ribonucleoside-triphosphate reductase - - - - - - - - - - - - NRDD k59_28107_7 1049564.TevJSym_bi00050 0.0 1151.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Ribonucleoside-triphosphate reductase nrdD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_4713,iPC815.YPO3454 ATP-cone,NRDD k59_28107_8 1121935.AQXX01000111_gene5832 1.12e-97 309.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales 135619|Oceanospirillales V (ABC) transporter - - - ko:K11004,ko:K13409 ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133 M00325,M00339,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2,3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_47519_1 930169.B5T_03503 8.25e-28 110.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1XK5U@135619|Oceanospirillales 135619|Oceanospirillales S periplasmic or secreted lipoprotein - - - - - - - - - - - - BON k59_8717_1 880073.Calab_2231 1.73e-52 178.0 COG5464@1|root,COG5464@2|Bacteria 2|Bacteria S double-stranded DNA endodeoxyribonuclease activity - - - - - - - - - - - - DUF4351,Transposase_31 k59_86462_1 439235.Dalk_3626 1.01e-111 333.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2MI99@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_157726_1 572477.Alvin_2155 4.42e-173 492.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_177331_1 1232437.KL661978_gene3792 1.14e-46 155.0 COG0664@1|root,COG0664@2|Bacteria,1NAYS@1224|Proteobacteria,42W1E@68525|delta/epsilon subdivisions,2WS96@28221|Deltaproteobacteria,2MMFZ@213118|Desulfobacterales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_41376_1 1144275.COCOR_01886 4.89e-07 54.3 COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,43EXH@68525|delta/epsilon subdivisions,2X2GW@28221|Deltaproteobacteria,2Z1XP@29|Myxococcales 28221|Deltaproteobacteria S Baseplate assembly protein - - - - - - - - - - - - - k59_86464_1 1120951.AUBG01000010_gene1850 4.11e-06 53.9 COG1538@1|root,COG1538@2|Bacteria,4NEEN@976|Bacteroidetes,1HWPI@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_66892_2 1120953.AUBH01000011_gene449 2.67e-40 149.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,465XQ@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_138024_1 1230343.CANP01000034_gene2560 1.26e-16 77.0 2EC13@1|root,3360B@2|Bacteria,1NG6Q@1224|Proteobacteria,1SEDP@1236|Gammaproteobacteria,1JEWR@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - k59_93232_1 1042375.AFPL01000031_gene837 1.12e-37 134.0 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,46B76@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF882) ycbK - - - - - - - - - - - Peptidase_M15_2 k59_93232_3 1049564.TevJSym_an00270 2.41e-108 319.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1J5W0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Elongation factor P--(R)-beta-lysine ligase epmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_34713_1 1242864.D187_004004 2.8e-47 172.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,2YTVV@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_47522_1 1049564.TevJSym_aw00110 6.28e-32 115.0 2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,1S5EP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - dsrJ - - - - - - - - - - - - k59_47522_2 1049564.TevJSym_aw00120 1.86e-127 381.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster dsrL - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2 k59_14718_1 748247.AZKH_4481 6.08e-89 266.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,2KV0X@206389|Rhodocyclales 206389|Rhodocyclales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_14718_2 1049564.TevJSym_bd00120 3.1e-21 90.1 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1JAAI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301 - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_119148_1 926692.AZYG01000040_gene1536 1.54e-20 94.7 COG1560@1|root,COG1560@2|Bacteria,1TT7A@1239|Firmicutes,24HMK@186801|Clostridia,3WANH@53433|Halanaerobiales 186801|Clostridia M PFAM Bacterial lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_34715_1 156889.Mmc1_2503 3.42e-100 307.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_177342_1 316067.Geob_3374 1.1e-98 305.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_105789_1 587753.EY04_18240 4.42e-40 147.0 COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R3R7@1224|Proteobacteria,1S0GX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Type VI secretion fha1 - - ko:K07169,ko:K11894,ko:K11913 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko02044 3.A.23.1 - - FHA k59_105789_2 1488328.JMCL01000013_gene341 2.98e-27 107.0 COG3521@1|root,COG3521@2|Bacteria,1N80I@1224|Proteobacteria,1SC9V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type VI secretion vasD - - ko:K11906 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS-SciN k59_105789_4 1218084.BBJK01000017_gene1822 9.87e-158 460.0 COG3522@1|root,COG3522@2|Bacteria,1MXKE@1224|Proteobacteria,2VKW8@28216|Betaproteobacteria,1K1D3@119060|Burkholderiaceae 28216|Betaproteobacteria S type VI secretion protein - - - ko:K11893 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VasE k59_34718_1 1430440.MGMSRv2_1070 5.4e-72 229.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2U2F7@28211|Alphaproteobacteria,2JPK6@204441|Rhodospirillales 204441|Rhodospirillales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_80171_1 243275.TDE_1986 1.42e-46 176.0 COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,2J5GP@203691|Spirochaetes 203691|Spirochaetes T guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_112412_5 1487953.JMKF01000022_gene2508 2.55e-15 79.3 COG1597@1|root,COG1803@1|root,COG1597@2|Bacteria,COG1803@2|Bacteria,1G25B@1117|Cyanobacteria,1H9PD@1150|Oscillatoriales 1117|Cyanobacteria GI PFAM Diacylglycerol kinase, catalytic domain mgsA - - - - - - - - - - - DAGK_cat,MGS k59_112412_6 1033802.SSPSH_002618 1.43e-16 88.6 COG0438@1|root,COG0438@2|Bacteria,1N1RZ@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_125640_1 519989.ECTPHS_00755 1.56e-06 48.9 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,1RRHZ@1236|Gammaproteobacteria,1WW8V@135613|Chromatiales 135613|Chromatiales S Fic/DOC family - - - - - - - - - - - - Fic k59_125640_2 207559.Dde_2493 0.0 1420.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2M96Z@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM type III restriction protein res subunit - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII k59_125640_4 62928.azo2352 2.04e-57 181.0 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,2KX92@206389|Rhodocyclales 206389|Rhodocyclales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_125640_5 62928.azo2353 3.15e-76 229.0 COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,2VS5B@28216|Betaproteobacteria 28216|Betaproteobacteria T Low molecular weight phosphatase family - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_125640_6 748247.AZKH_p0046 1.9e-28 111.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales 206389|Rhodocyclales P COG0798 Arsenite efflux pump ACR3 and related permeases arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_151439_1 1049564.TevJSym_ai00290 4.53e-63 209.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J4Y2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_151439_2 1444770.AF72_00215 3.69e-06 52.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion pilA - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_177346_1 1049564.TevJSym_af00420 1.09e-269 759.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1J56P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_34721_1 243233.MCA0812 6.4e-104 321.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1XDVD@135618|Methylococcales 135618|Methylococcales I Squalene cyclase - - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_66899_1 998088.B565_1021 1.68e-19 85.9 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1Y59Z@135624|Aeromonadales 135624|Aeromonadales IQ Fungal family of unknown function (DUF1776) - - - - - - - - - - - - adh_short k59_66899_2 292415.Tbd_1111 1.28e-29 110.0 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,2VWT7@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_66899_3 1158150.KB906241_gene880 1.28e-61 206.0 COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1X0UF@135613|Chromatiales 135613|Chromatiales NU Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16 k59_66899_4 522306.CAP2UW1_4419 2.16e-51 165.0 COG2329@1|root,COG2329@2|Bacteria,1RE6Q@1224|Proteobacteria,2VTH5@28216|Betaproteobacteria 28216|Betaproteobacteria C Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_177347_1 118161.KB235919_gene6400 1.3e-37 134.0 COG3415@1|root,COG3415@2|Bacteria,1GEDQ@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_119149_1 1190603.AJYD01000039_gene2959 4e-05 45.4 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1XTSS@135623|Vibrionales 135623|Vibrionales P once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015232,GO:0015886,GO:0022857,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:1901678 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_119149_2 1049564.TevJSym_al00580 2.54e-42 141.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1RXCG@1236|Gammaproteobacteria,1JBB2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Rieske-like [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_119149_3 1249627.D779_3302 1e-144 421.0 COG0547@1|root,COG0547@2|Bacteria,1QDR6@1224|Proteobacteria,1T9UH@1236|Gammaproteobacteria,1WW56@135613|Chromatiales 135613|Chromatiales E PFAM Glycosyl transferase, family - - - - - - - - - - - - Glycos_trans_3N,Glycos_transf_3 k59_119467_1 221288.JH992901_gene2523 6.9e-67 235.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1GQQT@1117|Cyanobacteria 1117|Cyanobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,Response_reg k59_119467_2 870967.VIS19158_13627 8.57e-47 159.0 COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,1RQA9@1236|Gammaproteobacteria,1XTEX@135623|Vibrionales 135623|Vibrionales J Belongs to the pseudouridine synthase RsuA family rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_196535_4 587753.EY04_00335 1.34e-37 135.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_196535_5 977880.RALTA_A1081 6.19e-185 540.0 COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2VMGB@28216|Betaproteobacteria 28216|Betaproteobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_145245_1 653733.Selin_0023 4.14e-28 117.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482,ko:K18143 ko01501,map01501 M00649,M00655 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - FeS,Fe_hyd_lg_C,Fer4,HAMP,HATPase_c,HisKA,MFS_1,dCache_1 k59_164398_1 1118153.MOY_14132 2.03e-40 145.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1SZ0B@1236|Gammaproteobacteria,1XRJU@135619|Oceanospirillales 135619|Oceanospirillales E FAD dependent oxidoreductase - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_3869_1 34506.g1199 9.66e-55 185.0 COG2801@1|root,2R29R@2759|Eukaryota,3AKFR@33154|Opisthokonta,3CKNF@33208|Metazoa,3E28S@33213|Bilateria,40PX4@6231|Nematoda,1M7EG@119089|Chromadorea,4161H@6236|Rhabditida 33208|Metazoa L HTH-like domain - - - - - - - - - - - - HTH_21,rve k59_179622_1 1049564.TevJSym_ag00180 1.16e-99 301.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1J59J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_30329_1 96561.Dole_1062 8.74e-18 87.8 COG2114@1|root,COG2114@2|Bacteria,1NQPW@1224|Proteobacteria 1224|Proteobacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - - k59_44396_1 85643.Tmz1t_2229 1.05e-82 271.0 28JFH@1|root,2Z99F@2|Bacteria,1PJEF@1224|Proteobacteria,2VMP9@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM CRISPR-associated protein, Cse1 family - - - ko:K19123 - - - - ko00000,ko02048 - - - - k59_44396_4 243233.MCA0933 4.57e-143 419.0 COG1857@1|root,COG1857@2|Bacteria,1MVNH@1224|Proteobacteria,1RMBZ@1236|Gammaproteobacteria,1XFHI@135618|Methylococcales 135618|Methylococcales L CRISPR-associated protein - - - ko:K19124 - - - - ko00000,ko02048 - - - Cas_CT1975 k59_44396_5 243233.MCA0932 4.31e-110 323.0 2DBE4@1|root,2Z8QG@2|Bacteria,1RAK5@1224|Proteobacteria,1RZVI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S CRISPR-associated protein Cas5 cas5e - - ko:K19125 - - - - ko00000,ko02048 - - - Cas_Cas5d k59_44396_6 243233.MCA0931 6.15e-69 218.0 2DMIY@1|root,32RWI@2|Bacteria,1RGHV@1224|Proteobacteria,1S1ZF@1236|Gammaproteobacteria,1XFXU@135618|Methylococcales 135618|Methylococcales S CRISPR-associated protein - - - ko:K19126 - - - - ko00000,ko02048 - - - CRISPR_assoc k59_44396_7 243233.MCA0930 3.46e-165 467.0 COG1518@1|root,COG1518@2|Bacteria,1MUXH@1224|Proteobacteria,1RP48@1236|Gammaproteobacteria,1XFE2@135618|Methylococcales 135618|Methylococcales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_44396_8 1265502.KB905937_gene2521 2.85e-29 106.0 2CJ5C@1|root,32S99@2|Bacteria,1N1AR@1224|Proteobacteria,2VV6D@28216|Betaproteobacteria 28216|Betaproteobacteria S CRISPR-associated protein Cas2 - - - ko:K09951 - - - - ko00000,ko02048 - - - Cas_Cas2CT1978 k59_69638_1 1167006.UWK_00560 1.43e-60 207.0 COG3005@1|root,COG3005@2|Bacteria,1NFFE@1224|Proteobacteria,430BS@68525|delta/epsilon subdivisions,2WVRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_205203_4 765912.Thimo_1124 2.16e-25 102.0 28IPJ@1|root,2Z8PI@2|Bacteria,1N3K3@1224|Proteobacteria,1S87S@1236|Gammaproteobacteria,1WYS7@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_147110_1 439235.Dalk_2276 1.67e-236 663.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hynA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 ko:K00437,ko:K00533,ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R00019,R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_128393_1 1237149.C900_01709 7.83e-72 230.0 COG5433@1|root,COG5433@2|Bacteria,4NHJC@976|Bacteroidetes,47X71@768503|Cytophagia 976|Bacteroidetes L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_108299_3 1131269.AQVV01000004_gene614 4.27e-15 77.4 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,Cohesin,DUF11,SLH k59_63067_1 1121405.dsmv_3476 1.94e-120 369.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MJ6A@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_101255_1 1049564.TevJSym_aa00050 9.76e-169 474.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1J4FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_128401_1 1049564.TevJSym_ao00710 1.28e-119 352.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1J4JQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_82386_1 1219035.NT2_27_00020 2.71e-11 67.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2K503@204457|Sphingomonadales 204457|Sphingomonadales L PFAM Transposase IS116 IS110 IS902 family, Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_140287_1 1232683.ADIMK_1381 7.96e-44 159.0 COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RS4V@1236|Gammaproteobacteria,46A0K@72275|Alteromonadaceae 1236|Gammaproteobacteria ET Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - HATPase_c,HisKA,SBP_bac_3 k59_140287_2 338966.Ppro_0378 2.08e-34 131.0 COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_114565_2 1049564.TevJSym_ab01880 4.72e-90 277.0 COG2885@1|root,COG2885@2|Bacteria,1PGGZ@1224|Proteobacteria,1RNFU@1236|Gammaproteobacteria,1J6T3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins motY - - ko:K21218 ko02040,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_55817_1 1121405.dsmv_3773 1.8e-81 266.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,42NY6@68525|delta/epsilon subdivisions,2WJSE@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_186500_1 765911.Thivi_3089 8.34e-165 467.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_186500_2 1049564.TevJSym_ak00430 9.17e-141 403.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1J5D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726 Shikimate_DH,Shikimate_dh_N k59_198403_2 1123228.AUIH01000091_gene568 2.37e-23 98.2 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XHYC@135619|Oceanospirillales 135619|Oceanospirillales L recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_69650_1 857087.Metme_1778 2.04e-136 402.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1XEHB@135618|Methylococcales 135618|Methylococcales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_128405_1 931276.Cspa_c39240 1.24e-33 131.0 COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,36G19@31979|Clostridiaceae 186801|Clostridia H Belongs to the UbiD family - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_147125_1 1265505.ATUG01000002_gene1766 5.2e-132 389.0 COG0069@1|root,COG1143@1|root,COG0069@2|Bacteria,COG1143@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,2MHXF@213118|Desulfobacterales 28221|Deltaproteobacteria E Conserved region in glutamate synthase - - - - - - - - - - - - Fer4,Glu_synthase k59_205211_1 1188256.BASI01000002_gene3549 7.61e-51 166.0 COG3415@1|root,COG3415@2|Bacteria,1RFNA@1224|Proteobacteria,2USJR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - - k59_205211_2 1485545.JQLW01000010_gene1491 4.95e-154 444.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,HTH_32,rve,rve_3 k59_101264_1 754476.Q7A_2836 2.2e-34 127.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_121898_1 748658.KB907321_gene848 1.36e-31 115.0 COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,1RRGB@1236|Gammaproteobacteria,1X08N@135613|Chromatiales 135613|Chromatiales K Bacterial regulatory protein, arsR family - - - - - - - - - - - - MarR_2 k59_121898_2 395493.BegalDRAFT_2873 2.01e-117 356.0 COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,1S2PQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM DoxX-like family - - - - - - - - - - - - DoxX_3,Epimerase,NAD_binding_10 k59_121898_3 1042375.AFPL01000046_gene1838 2.28e-60 191.0 COG5528@1|root,COG5528@2|Bacteria,1RDUE@1224|Proteobacteria,1S5XB@1236|Gammaproteobacteria,46BNY@72275|Alteromonadaceae 1236|Gammaproteobacteria S Predicted integral membrane protein (DUF2269) - - - - - - - - - - - - DUF2269 k59_63076_1 118166.JH976538_gene5032 8.05e-17 83.2 2DMRP@1|root,32T7T@2|Bacteria,1GQUS@1117|Cyanobacteria,1HI0Y@1150|Oscillatoriales 1117|Cyanobacteria S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_128408_1 1123400.KB904748_gene336 4.39e-37 137.0 COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,1S0QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family M28 yfbL - - - - - - - - - - - Peptidase_M28 k59_121899_1 1121405.dsmv_0465 2.91e-27 105.0 COG4967@1|root,COG4967@2|Bacteria,1PSVQ@1224|Proteobacteria,437CX@68525|delta/epsilon subdivisions,2X2IS@28221|Deltaproteobacteria,2MM7T@213118|Desulfobacterales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02458 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_172655_1 1522072.IL54_3158 2.8e-167 505.0 COG4227@1|root,COG4643@1|root,COG4227@2|Bacteria,COG4643@2|Bacteria,1MU8I@1224|Proteobacteria,2TRIT@28211|Alphaproteobacteria,2K1FU@204457|Sphingomonadales 204457|Sphingomonadales L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738 k59_172655_2 1198232.CYCME_3032 1.32e-19 81.6 2ECPN@1|root,336MF@2|Bacteria,1N5T3@1224|Proteobacteria,1SH25@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_172655_4 339670.Bamb_6614 3.83e-258 724.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K2G6@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA topoisomerase - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_198408_1 631362.Thi970DRAFT_04626 5.58e-26 101.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1WWSS@135613|Chromatiales 135613|Chromatiales J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_198408_2 1049564.TevJSym_ad00090 1.64e-29 105.0 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1J7AC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_198408_3 983545.Glaag_2548 5.69e-54 171.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,466ZJ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_186510_1 706587.Desti_3938 3.1e-20 90.1 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Single-stranded nucleic acid binding R3H - - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_186510_2 1232443.BAIA02000155_gene1811 4.03e-17 82.8 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,267NB@186813|unclassified Clostridiales 186801|Clostridia S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_153433_1 1265505.ATUG01000002_gene1022 1.76e-44 160.0 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1R7WZ@1224|Proteobacteria,42Q3R@68525|delta/epsilon subdivisions,2WM5A@28221|Deltaproteobacteria,2MIDF@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,SSF,SpoIIE k59_69660_1 439235.Dalk_1103 1.1e-105 317.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2MIFI@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2910 ThiC_Rad_SAM k59_205212_1 877411.JMMA01000002_gene294 8.24e-45 157.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,3WH07@541000|Ruminococcaceae 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_205212_2 443143.GM18_3894 1.89e-08 55.5 COG3116@1|root,COG3116@2|Bacteria,1NKRZ@1224|Proteobacteria,42XDD@68525|delta/epsilon subdivisions,2WSII@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Cell division protein FtsL ftsL - - - - - - - - - - - DivIC,FtsL k59_205212_3 1232410.KI421421_gene3858 1.29e-14 75.9 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales 28221|Deltaproteobacteria M PASTA domain ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_30348_1 1167006.UWK_03453 2.04e-08 58.9 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MI3D@213118|Desulfobacterales 28221|Deltaproteobacteria L UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_186513_1 1049564.TevJSym_ad01330 3.46e-63 207.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1J4V5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_49903_1 754252.PFREUD_10850 6.93e-16 75.9 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DPPJ@85009|Propionibacteriales 201174|Actinobacteria E Amino acid amide ABC transporter ATP-binding protein 1, HAAT family livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_49903_2 1125863.JAFN01000001_gene3440 5.64e-63 199.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_160166_1 1230476.C207_06448 1.44e-54 197.0 2AKSW@1|root,31BJX@2|Bacteria,1NZA4@1224|Proteobacteria,2USXQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_160166_3 748658.KB907328_gene1082 1.07e-35 124.0 COG3668@1|root,COG3668@2|Bacteria,1PZJI@1224|Proteobacteria,1S7PQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_160166_4 1396858.Q666_04440 6.54e-28 104.0 COG3609@1|root,COG3609@2|Bacteria,1N7IM@1224|Proteobacteria,1SEQZ@1236|Gammaproteobacteria,468SP@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH - - - ko:K07746 - - - - ko00000,ko02048 - - - ParD_antitoxin k59_24154_1 156889.Mmc1_2862 1.65e-35 134.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_30350_1 1249627.D779_0805 9.65e-17 85.1 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,1S0ET@1236|Gammaproteobacteria 1236|Gammaproteobacteria PT FecR protein - - - - - - - - - - - - FecR,TPR_16,TPR_19,TonB_dep_Rec k59_114580_1 1037409.BJ6T_56200 1.04e-52 182.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2TU9Q@28211|Alphaproteobacteria,3JW1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_63086_1 192952.MM_0485 1.99e-35 133.0 COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,2N98M@224756|Methanomicrobia 224756|Methanomicrobia G Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_192369_2 1056820.KB900638_gene66 8.23e-30 117.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_88680_2 953739.SVEN_0928 1.07e-122 372.0 COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria 201174|Actinobacteria C Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_37501_1 1210908.HSB1_26660 2.31e-05 51.2 COG0025@1|root,arCOG01961@2157|Archaea,2XVSR@28890|Euryarchaeota,23SF7@183963|Halobacteria 183963|Halobacteria P COG0025 NhaP-type Na H and K H antiporters - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_63381_2 765913.ThidrDRAFT_4144 3.81e-138 406.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1WVVM@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_63381_3 765913.ThidrDRAFT_4145 1.24e-17 81.3 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales 135613|Chromatiales U Hydrophobe Amphiphile Efflux-1 (HAE1) - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_198654_1 246194.CHY_1005 1.08e-55 182.0 COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,42F2T@68295|Thermoanaerobacterales 186801|Clostridia N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_114859_2 1049564.TevJSym_ax00220 3.66e-79 238.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1JAG9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Redoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_114859_3 1249627.D779_0418 1.19e-65 203.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_17195_1 177437.HRM2_02860 1.07e-24 100.0 COG1811@1|root,COG1811@2|Bacteria,1MX1D@1224|Proteobacteria,42S9G@68525|delta/epsilon subdivisions,2WNUQ@28221|Deltaproteobacteria,2MJME@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF554) - - - ko:K07150 - - - - ko00000 - - - DUF554 k59_17195_2 1408312.JNJS01000001_gene1490 1.36e-09 58.5 COG1102@1|root,COG1102@2|Bacteria,1V30Q@1239|Firmicutes,24G07@186801|Clostridia,3NI4X@46205|Pseudobutyrivibrio 186801|Clostridia F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_122230_2 1279015.KB908455_gene1400 4.29e-102 306.0 COG0589@1|root,COG0589@2|Bacteria,1PAFP@1224|Proteobacteria,1RSCS@1236|Gammaproteobacteria,1Y54J@135624|Aeromonadales 135624|Aeromonadales T Universal stress protein family - - - - - - - - - - - - Usp k59_122230_3 1323663.AROI01000004_gene2045 8.19e-267 741.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) ybaR1 - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_108697_1 1079460.ATTQ01000045_gene6046 1.49e-97 292.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U28T@28211|Alphaproteobacteria,4BE1X@82115|Rhizobiaceae 28211|Alphaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_116604_1 439235.Dalk_0476 1.16e-20 83.6 COG1609@1|root,COG1609@2|Bacteria,1QW0S@1224|Proteobacteria,43BQP@68525|delta/epsilon subdivisions,2X71R@28221|Deltaproteobacteria,2MM94@213118|Desulfobacterales 28221|Deltaproteobacteria K Helix-turn-helix - - - - - - - - - - - - HTH_3 k59_116604_2 933262.AXAM01000013_gene1296 2.46e-11 63.5 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales 28221|Deltaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_142520_1 1265505.ATUG01000001_gene4526 3.04e-36 131.0 COG2404@1|root,COG2404@2|Bacteria,1QW0R@1224|Proteobacteria,43BQN@68525|delta/epsilon subdivisions,2X71Q@28221|Deltaproteobacteria,2MHUX@213118|Desulfobacterales 28221|Deltaproteobacteria S COG0618 Exopolyphosphatase-related proteins - - - - - - - - - - - - - k59_19073_1 1049564.TevJSym_bu00050 3.67e-140 432.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_200315_1 96561.Dole_2832 1.23e-81 249.0 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,42ZZ0@68525|delta/epsilon subdivisions,2WVJ4@28221|Deltaproteobacteria,2MNIC@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_200315_2 697284.ERIC2_c15970 8.91e-21 94.7 COG0084@1|root,COG0084@2|Bacteria,1TQUP@1239|Firmicutes,4HBEN@91061|Bacilli,26UES@186822|Paenibacillaceae 91061|Bacilli L TatD related DNase M1-591 - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_148990_1 857087.Metme_1124 2.06e-29 120.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_148990_2 1121380.JNIW01000004_gene549 1.37e-15 80.1 COG2199@1|root,COG3706@2|Bacteria,1WJX7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GGDEF,TPR_10,TPR_12,TPR_7,TPR_8 k59_148990_3 203122.Sde_3266 5.74e-124 369.0 2E0EH@1|root,32W10@2|Bacteria,1NV08@1224|Proteobacteria,1SNIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_148990_4 926569.ANT_06360 2.37e-165 473.0 COG2089@1|root,COG2089@2|Bacteria,2G8PB@200795|Chloroflexi 200795|Chloroflexi M SAF - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_148990_5 1079460.ATTQ01000023_gene308 4.46e-51 172.0 COG3271@1|root,COG3271@2|Bacteria,1R6YT@1224|Proteobacteria,2U4I7@28211|Alphaproteobacteria,4BD6X@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phytochelatin synthase - - - - - - - - - - - - Phytochelatin k59_148990_6 711393.AYRX01000079_gene5291 1.57e-92 288.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_206981_1 118166.JH976537_gene2193 1.6e-72 227.0 COG1216@1|root,COG1216@2|Bacteria,1G0X3@1117|Cyanobacteria,1HHXX@1150|Oscillatoriales 1117|Cyanobacteria S Glycosyl transferase family 2 - - - ko:K09931 - - - - ko00000 - - - DUF2064,Glycos_transf_2 k59_103259_1 96561.Dole_0660 7.75e-60 197.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_194407_1 933262.AXAM01000013_gene1300 1.97e-48 174.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2MHUC@213118|Desulfobacterales 28221|Deltaproteobacteria U type II and III secretion system protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_168343_1 1304885.AUEY01000005_gene842 1.05e-86 271.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MJG3@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_168345_1 425104.Ssed_2865 2.52e-61 213.0 COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QACP@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase A domain protein - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - CHASE,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_1 k59_57719_1 333138.LQ50_14315 2.63e-27 108.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,1ZBA4@1386|Bacillus 91061|Bacilli E Belongs to the ABC transporter superfamily appF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_142537_1 1121396.KB893100_gene4319 2.03e-72 246.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_155466_1 911008.GLAD_02509 1.21e-07 60.1 COG4916@1|root,COG4916@2|Bacteria 2|Bacteria S TIR domain - - - - - - - - - - - - TIR_2 k59_155466_2 1116472.MGMO_50c00080 2.79e-187 531.0 COG3621@1|root,COG3621@2|Bacteria,1R852@1224|Proteobacteria,1S106@1236|Gammaproteobacteria,1XESW@135618|Methylococcales 135618|Methylococcales S PFAM Patatin - - - - - - - - - - - - Patatin k59_155466_3 69042.WH5701_09219 3.09e-262 743.0 COG0457@1|root,COG0457@2|Bacteria,1GPNI@1117|Cyanobacteria,1H3JS@1129|Synechococcus 1117|Cyanobacteria S Domain of unknown function (DUF4071) - - - - - - - - - - - - DUF4071 k59_155466_4 762376.AXYL_00696 5.32e-35 128.0 COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria,2VUX7@28216|Betaproteobacteria,3T7FP@506|Alcaligenaceae 28216|Betaproteobacteria S GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like k59_174540_1 443143.GM18_2506 8.11e-194 545.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,43S0U@69541|Desulfuromonadales 28221|Deltaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_174540_3 1202962.KB907150_gene1910 2.6e-50 161.0 COG0346@1|root,COG0346@2|Bacteria,1N706@1224|Proteobacteria,1SE96@1236|Gammaproteobacteria 1236|Gammaproteobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - - k59_174540_5 84531.JMTZ01000018_gene3937 1.32e-25 97.4 COG2350@1|root,COG2350@2|Bacteria,1QBAU@1224|Proteobacteria,1T6VA@1236|Gammaproteobacteria,1X889@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - - - - - - - - - - YCII k59_174540_7 572477.Alvin_1116 3.23e-96 286.0 2CCI4@1|root,30BPJ@2|Bacteria,1RE42@1224|Proteobacteria,1S47G@1236|Gammaproteobacteria,1X0PJ@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_174540_9 357804.Ping_0964 7.83e-13 67.0 2E5B0@1|root,33033@2|Bacteria,1ND0X@1224|Proteobacteria,1SEBX@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_174540_12 159087.Daro_2533 1.8e-95 285.0 COG0346@1|root,COG0346@2|Bacteria,1RD81@1224|Proteobacteria,2VVM9@28216|Betaproteobacteria 28216|Betaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_3 k59_174540_14 56780.SYN_01374 3.28e-70 234.0 COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_200340_1 96561.Dole_2573 3.01e-84 273.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_142541_1 323261.Noc_3020 6.07e-80 251.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_103710_1 240015.ACP_0482 1.43e-61 211.0 COG0612@1|root,COG0612@2|Bacteria,3Y3W3@57723|Acidobacteria,2JMK9@204432|Acidobacteriia 204432|Acidobacteriia S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_12971_2 1304878.AUGD01000040_gene3272 1.32e-38 134.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,3JZI8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_123156_1 522373.Smlt1089 1.05e-98 295.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1X3Y4@135614|Xanthomonadales 135614|Xanthomonadales NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_162041_2 1125863.JAFN01000001_gene2306 5.43e-39 132.0 COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_64828_1 1238182.C882_4235 2.73e-63 202.0 COG1116@1|root,COG1116@2|Bacteria,1RASI@1224|Proteobacteria,2U3AE@28211|Alphaproteobacteria,2JSI2@204441|Rhodospirillales 204441|Rhodospirillales P ABC transporter - - - ko:K15600 ko02010,map02010 M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 - - ABC_tran k59_181492_2 1122947.FR7_0534 2.53e-08 53.1 2DRAI@1|root,33AYP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_181494_1 552811.Dehly_1535 1.26e-44 157.0 COG3547@1|root,COG3547@2|Bacteria,2G8GZ@200795|Chloroflexi 200795|Chloroflexi L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_25935_1 1265505.ATUG01000003_gene658 4.71e-12 64.3 2A1M5@1|root,30PV9@2|Bacteria,1N5W2@1224|Proteobacteria,42RI6@68525|delta/epsilon subdivisions,2WNKT@28221|Deltaproteobacteria,2MJVG@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_25935_2 525897.Dbac_1840 1.51e-189 541.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_51868_1 1279038.KB907337_gene127 5.81e-215 610.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_6488_1 243231.GSU1075 5.95e-12 63.5 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,42QPX@68525|delta/epsilon subdivisions,2WNF9@28221|Deltaproteobacteria,43US0@69541|Desulfuromonadales 28221|Deltaproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_6488_2 204536.SULAZ_1049 7.33e-15 72.8 COG0217@1|root,COG0217@2|Bacteria,2G3N5@200783|Aquificae 200783|Aquificae K transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_77796_1 1144319.PMI16_02666 3.32e-31 110.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,474TX@75682|Oxalobacteraceae 28216|Betaproteobacteria K 'Cold-shock' DNA-binding domain cspD2 - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_77796_2 998674.ATTE01000001_gene1696 1e-70 225.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,4623N@72273|Thiotrichales 72273|Thiotrichales C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_12985_1 1123288.SOV_2c00020 1.03e-08 62.0 COG1216@1|root,COG2519@1|root,COG1216@2|Bacteria,COG2519@2|Bacteria,1UYDM@1239|Firmicutes,4H6HX@909932|Negativicutes 909932|Negativicutes J Glycosyltransferase group 2 family protein - - - - - - - - - - - - Glycos_transf_2 k59_25940_1 1049564.TevJSym_ah00310 1.65e-45 155.0 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SWYJ@1236|Gammaproteobacteria,1J6IG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Anti sigma-E protein RseA, N-terminal domain - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_25940_2 1049564.TevJSym_ah00320 5.24e-111 333.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1J65J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T MucB/RseB C-terminal domain rseB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152 - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_77799_1 1453501.JELR01000002_gene1177 1.42e-30 122.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,46535@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0581 ABC-type phosphate transport system, permease component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_25942_2 1049564.TevJSym_aj00290 6.22e-51 174.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_116687_1 1125863.JAFN01000001_gene2523 2.07e-44 150.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,42UAT@68525|delta/epsilon subdivisions,2WQ31@28221|Deltaproteobacteria 28221|Deltaproteobacteria M This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_45377_1 933262.AXAM01000060_gene2891 3e-103 313.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI07@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_123164_1 870187.Thini_0255 1.82e-42 149.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1R7ZF@1224|Proteobacteria,1S6YQ@1236|Gammaproteobacteria,461FS@72273|Thiotrichales 1236|Gammaproteobacteria L PFAM Insertion element protein - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_123164_2 314278.NB231_08267 0.000609 41.2 2EBS0@1|root,335RU@2|Bacteria,1NDSC@1224|Proteobacteria,1SF6N@1236|Gammaproteobacteria,1X197@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_45378_1 794846.AJQU01000013_gene1896 0.000709 45.8 COG0454@1|root,COG0456@2|Bacteria,1RH0C@1224|Proteobacteria,2U9B4@28211|Alphaproteobacteria,4BF1J@82115|Rhizobiaceae 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain phnO - - - - - - - - - - - Acetyltransf_1 k59_97253_1 402626.Rpic_3143 7.43e-05 49.7 COG0642@1|root,COG0745@1|root,COG2197@1|root,COG0745@2|Bacteria,COG2197@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae 28216|Betaproteobacteria T catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_38905_1 1121447.JONL01000007_gene1154 7.24e-55 185.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,42NJB@68525|delta/epsilon subdivisions,2WM62@28221|Deltaproteobacteria,2M967@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2333) - - - - - - - - - - - - DUF2333 k59_84279_1 1322246.BN4_11946 1.2e-62 209.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2M8QM@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - iAF987.Gmet_0470 CPT,CbiA,GATase_3 k59_116689_1 1049564.TevJSym_aj00800 6.65e-102 299.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1J9UJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - ko:K00184,ko:K21308 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 5.A.3 - - Fer4_11,Fer4_4,Fer4_7,Molydop_binding k59_116689_2 1049564.TevJSym_aj00790 1.52e-44 152.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1RS3Q@1236|Gammaproteobacteria,1JB7K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DMSO reductase anchor subunit (DmsC) dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_187978_1 159087.Daro_3872 3.24e-21 100.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_187978_2 857087.Metme_2134 9.43e-98 300.0 COG3287@1|root,COG3287@2|Bacteria,1R825@1224|Proteobacteria,1S25E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_71317_1 472759.Nhal_0327 1.47e-95 297.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales 135613|Chromatiales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_136128_1 933262.AXAM01000033_gene1642 1.13e-93 292.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 k59_77813_1 1304885.AUEY01000040_gene1615 1.84e-09 59.3 COG0745@1|root,COG0745@2|Bacteria,1RIGT@1224|Proteobacteria,42SWP@68525|delta/epsilon subdivisions,2WPJ3@28221|Deltaproteobacteria,2MK4B@213118|Desulfobacterales 28221|Deltaproteobacteria T Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,Response_reg k59_45383_1 1249627.D779_1704 6.86e-64 207.0 2E2KC@1|root,32XPP@2|Bacteria,1R4ZI@1224|Proteobacteria,1RZVK@1236|Gammaproteobacteria,1WWI9@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_45383_2 414684.RC1_3345 2.22e-68 223.0 COG0596@1|root,COG0596@2|Bacteria,1RGAP@1224|Proteobacteria,2UCT5@28211|Alphaproteobacteria,2JX6M@204441|Rhodospirillales 204441|Rhodospirillales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_103722_1 1232437.KL661985_gene3581 3.04e-86 266.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria,2MJ70@213118|Desulfobacterales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_149097_1 768671.ThimaDRAFT_0640 1.54e-11 72.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X0IK@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_3,PAS_4,PAS_9,Response_reg k59_84287_1 644281.MFS40622_0145 3.09e-06 47.0 COG0662@1|root,arCOG03003@2157|Archaea,2XZQ5@28890|Euryarchaeota 28890|Euryarchaeota G Mannose-6-phosphate isomerase - - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - Cupin_2 k59_84287_2 56780.SYN_03353 5.43e-32 120.0 COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria 1224|Proteobacteria F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_12986_1 765911.Thivi_2316 7.68e-140 404.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales 135613|Chromatiales M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_162223_1 1049564.TevJSym_ab01860 1.31e-22 97.1 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1J4YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_162223_2 1049564.TevJSym_ab01850 2.79e-170 491.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1J4XV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_64945_1 1265505.ATUG01000001_gene4505 1.54e-20 93.6 COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria,2MJJZ@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H k59_123336_1 868864.Dester_0416 3.86e-08 53.9 COG1905@1|root,COG1905@2|Bacteria,2G48R@200783|Aquificae 200783|Aquificae C NADH dehydrogenase (ubiquinone) 24 kDa subunit nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_123336_2 1033806.HTIA_1871 1.98e-67 227.0 COG1894@1|root,arCOG04537@2157|Archaea,2XUYN@28890|Euryarchaeota,23SN8@183963|Halobacteria 183963|Halobacteria C COG1894 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit - - 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_168685_1 1499967.BAYZ01000117_gene3312 3.44e-12 64.7 COG4665@1|root,COG4665@2|Bacteria 2|Bacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_168685_2 998674.ATTE01000001_gene3512 1.97e-125 364.0 COG4663@1|root,COG4663@2|Bacteria,1MUA1@1224|Proteobacteria,1RYNZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q C4-dicarboxylate ABC transporter - - - - - - - - - - - - DctP k59_71453_1 67275.JOAP01000084_gene3399 2.91e-35 133.0 COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria 201174|Actinobacteria E Belongs to the ABC transporter superfamily appF - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_136606_1 1379281.AVAG01000016_gene959 8.55e-61 197.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42PEN@68525|delta/epsilon subdivisions,2WJ9F@28221|Deltaproteobacteria,2M9B5@213115|Desulfovibrionales 28221|Deltaproteobacteria E Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_136606_2 56780.SYN_00788 1.08e-20 90.5 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NUE@68525|delta/epsilon subdivisions,2WJYH@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_194857_1 1123368.AUIS01000032_gene1395 7.27e-121 379.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,2NE5Q@225057|Acidithiobacillales 1236|Gammaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_201501_1 766499.C357_06926 1.91e-64 205.0 COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,2TSJZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Cobyrinic acid a,c-diamide synthase parA1 - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_97685_1 156889.Mmc1_2789 9.05e-50 169.0 COG3039@1|root,COG3039@2|Bacteria,1MXTN@1224|Proteobacteria,2TYT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_5 k59_136615_2 1121422.AUMW01000002_gene2280 4.42e-14 72.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25ZZ5@186807|Peptococcaceae 186801|Clostridia E PFAM Aminotransferase class I and II aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 k59_110647_2 1005048.CFU_3385 9.74e-125 366.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,472BJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Mycolic acid cyclopropane synthetase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_13406_3 1049564.TevJSym_aa01750 5.74e-64 204.0 COG1226@1|root,COG1226@2|Bacteria,1QRWR@1224|Proteobacteria,1SPPS@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Regulator of K conductance, N-terminal - - - - - - - - - - - - TrkA_C,TrkA_N k59_175457_1 106370.Francci3_2533 9.58e-85 278.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Phage_integrase k59_26434_2 1049564.TevJSym_ao00070 2.28e-99 302.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1J9E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3318 GDC-P k59_39334_1 1232410.KI421414_gene2841 9.32e-62 199.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,43RXH@69541|Desulfuromonadales 28221|Deltaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_149594_1 639282.DEFDS_2050 1.79e-28 113.0 COG2038@1|root,COG2038@2|Bacteria,2GEIU@200930|Deferribacteres 200930|Deferribacteres H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT - 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT k59_19935_1 472759.Nhal_3142 3e-90 295.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_52327_1 439235.Dalk_4332 1.36e-99 306.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_65280_1 163908.KB235896_gene4789 2.62e-22 100.0 COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1G26V@1117|Cyanobacteria,1HQUB@1161|Nostocales 1117|Cyanobacteria T Histidine Phosphotransfer domain - - - ko:K13490 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01001,ko02022 - - - CheW,HATPase_c,Hpt,Response_reg k59_149604_1 596151.DesfrDRAFT_1857 1.74e-65 217.0 COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2M8S3@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM RNA binding S1 domain protein - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_71785_1 1049564.TevJSym_am00430 2.92e-118 347.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1J9GT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_71785_2 1121935.AQXX01000144_gene4342 9.91e-76 236.0 COG0625@1|root,COG0625@2|Bacteria,1MX33@1224|Proteobacteria,1S4KF@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_6,GST_N_4 k59_143024_3 272134.KB731324_gene2188 8.42e-06 48.1 COG1783@1|root,COG5362@1|root,COG5410@1|root,COG1783@2|Bacteria,COG5362@2|Bacteria,COG5410@2|Bacteria 2|Bacteria K chromosome segregation - - - - - - - - - - - - Terminase_6,Terminase_6C k59_522_1 1123368.AUIS01000001_gene1918 1.68e-168 503.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_91235_1 1121405.dsmv_0420 4.05e-130 403.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2MIWJ@213118|Desulfobacterales 28221|Deltaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_175465_1 1266914.ATUK01000010_gene1514 4.01e-54 186.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_123628_2 1288494.EBAPG3_5880 2.59e-94 290.0 COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2VIWN@28216|Betaproteobacteria,372SU@32003|Nitrosomonadales 28216|Betaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_123628_4 61647.LG71_21060 1.95e-47 162.0 COG3545@1|root,COG3545@2|Bacteria,1RKTI@1224|Proteobacteria,1S66T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha beta hydrolase fold ydeN - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase k59_123628_5 1121939.L861_09825 2.14e-36 128.0 COG0789@1|root,COG0789@2|Bacteria,1NB52@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_123628_7 406817.XNC1_3746 2.98e-13 63.9 COG2161@1|root,COG2161@2|Bacteria,1N6X6@1224|Proteobacteria,1SDQ0@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Antitoxin component of a toxin-antitoxin (TA) module yefM - - ko:K19159 - - - - ko00000,ko02048 - - - PhdYeFM_antitox k59_32864_1 864051.BurJ1DRAFT_1704 1.31e-49 168.0 COG3409@1|root,COG3409@2|Bacteria,1N4WW@1224|Proteobacteria,2VH9D@28216|Betaproteobacteria,1KJ52@119065|unclassified Burkholderiales 28216|Betaproteobacteria M PFAM Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - CsgG,PG_binding_1 k59_32864_2 1049564.TevJSym_cb00030 9.11e-52 167.0 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1J72N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG3030 Protein affecting phage T7 exclusion by the F plasmid fxsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 - ko:K07113 - - - - ko00000 - - - FxsA k59_149613_1 1121405.dsmv_3556 9.12e-84 261.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2MJ1N@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_39351_4 335543.Sfum_1255 7.57e-71 216.0 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,42SZW@68525|delta/epsilon subdivisions,2WPFI@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_39351_5 1049564.TevJSym_ah00160 1.75e-87 265.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1J4PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9,4.3.1.9 ko:K00384,ko:K22345 ko00030,ko00450,map00030,map00450 - R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_162576_1 933262.AXAM01000177_gene2636 8.72e-51 171.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2MIHW@213118|Desulfobacterales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_39353_1 926692.AZYG01000085_gene856 4.62e-59 197.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales 186801|Clostridia L Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_188472_2 765913.ThidrDRAFT_4288 2.26e-115 338.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1X030@135613|Chromatiales 135613|Chromatiales E Bacterial transferase hexapeptide (six repeats) - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_188472_4 768671.ThimaDRAFT_2945 5.65e-41 138.0 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,1S999@1236|Gammaproteobacteria,1WYNZ@135613|Chromatiales 135613|Chromatiales J May protect the nitrogenase Fe-Mo protein from oxidative damage nifW - - ko:K02595 - - - - ko00000 - - - NifW k59_188472_5 1249627.D779_3151 4.32e-56 179.0 COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,1S6X5@1236|Gammaproteobacteria,1WY5W@135613|Chromatiales 135613|Chromatiales O PFAM NifZ - - - ko:K02597 - - - - ko00000 - - - NifZ k59_188472_6 870187.Thini_0351 1.27e-85 265.0 COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,1RY54@1236|Gammaproteobacteria 1236|Gammaproteobacteria O peptidylprolyl isomerase nifM - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase k59_188472_7 491952.Mar181_1412 2.21e-31 110.0 COG1942@1|root,COG1942@2|Bacteria,1N6WW@1224|Proteobacteria,1SC97@1236|Gammaproteobacteria,1XKYI@135619|Oceanospirillales 135619|Oceanospirillales G 4-oxalocrotonate tautomerase - - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - Tautomerase k59_188472_8 220664.PFL_1286 2.32e-12 67.8 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1YPFC@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_26446_1 523791.Kkor_0228 1.62e-59 211.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XIUV@135619|Oceanospirillales 135619|Oceanospirillales NT chemotaxis protein - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_181981_2 305700.B447_11197 5.5e-55 172.0 COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,2VSES@28216|Betaproteobacteria,2KWKG@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the urease gamma subunit family ureA - 3.5.1.5 ko:K01430 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_gamma k59_117189_1 370438.PTH_1727 1.95e-31 123.0 COG2199@1|root,COG5000@1|root,COG3706@2|Bacteria,COG5000@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,262DP@186807|Peptococcaceae 186801|Clostridia T GGDEF domain - - 2.7.7.65 ko:K02488,ko:K21022 ko02020,ko02025,ko04112,map02020,map02025,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,HAMP,PAS_9,dCache_1 k59_104164_1 1452718.JBOY01000167_gene1546 3.08e-97 295.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_104164_2 1249627.D779_2024 8.23e-19 85.9 2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,1WY9R@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_104164_3 1123518.ARWI01000001_gene1408 1.35e-58 186.0 COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,1S6P0@1236|Gammaproteobacteria,462TC@72273|Thiotrichales 72273|Thiotrichales S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_104164_4 1005048.CFU_0065 1.42e-38 147.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VMJI@28216|Betaproteobacteria,475DW@75682|Oxalobacteraceae 28216|Betaproteobacteria M RHS Repeat - - - - - - - - - - - - F5_F8_type_C,PAAR_motif,Peptidase_C39,RHS,RHS_repeat k59_13421_2 765912.Thimo_1847 1.97e-130 375.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1WXHX@135613|Chromatiales 135613|Chromatiales E TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_19939_1 1123368.AUIS01000031_gene1420 5.14e-22 96.3 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales 225057|Acidithiobacillales P STAS domain - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_19939_2 1163407.UU7_06998 8.47e-05 43.9 2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1X8YW@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_19939_4 237368.SCABRO_00207 3.27e-05 55.1 COG1572@1|root,COG2931@1|root,COG3291@1|root,COG3391@1|root,COG4733@1|root,COG5276@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4733@2|Bacteria,COG5276@2|Bacteria,2J3BU@203682|Planctomycetes 203682|Planctomycetes Q amine dehydrogenase activity - - - - - - - - - - - - - k59_130206_1 1439940.BAY1663_04438 5.48e-11 62.4 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_194889_1 1121937.AUHJ01000013_gene867 6.99e-30 131.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,466J7@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_194889_2 1049564.TevJSym_ac01530 1.23e-21 91.7 COG0790@1|root,COG0790@2|Bacteria,1PDUX@1224|Proteobacteria,1RW86@1236|Gammaproteobacteria,1JBN1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sel1-like repeats. - - - - - - - - - - - - Sel1 k59_194889_3 748658.KB907312_gene1558 1.31e-85 284.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_182013_1 642492.Clole_1267 0.000848 42.7 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_182013_2 1265505.ATUG01000002_gene2656 1.25e-47 155.0 COG1908@1|root,COG1908@2|Bacteria,1N4XV@1224|Proteobacteria,42UTE@68525|delta/epsilon subdivisions,2WQE3@28221|Deltaproteobacteria,2MKMT@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_538_1 1131730.BAVI_22193 4.54e-31 119.0 2DBV7@1|root,2ZB9P@2|Bacteria,1UBN2@1239|Firmicutes,4HEYF@91061|Bacilli,1ZEYB@1386|Bacillus 91061|Bacilli S Domain of unknown function (DUF4386) - - - - - - - - - - - - DUF4386 k59_52337_1 314345.SPV1_03033 3.63e-15 73.6 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria 1224|Proteobacteria T OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_52337_2 1278309.KB907100_gene2341 2.29e-24 104.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,1XI1N@135619|Oceanospirillales 135619|Oceanospirillales T diguanylate cyclase - - - - - - - - - - - - DSBA,GGDEF,Response_reg k59_84769_1 1123371.ATXH01000011_gene60 2.02e-19 91.3 COG3852@1|root,COG3852@2|Bacteria,2GI9Z@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_111031_2 765913.ThidrDRAFT_0293 3.52e-23 92.4 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1WYYA@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_111031_3 1049564.TevJSym_ac01300 6.26e-72 218.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1J6IB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG2867 Oligoketide cyclase lipid transport protein ratA GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 - - - - - - - - - - Polyketide_cyc k59_182377_1 237368.SCABRO_01552 8.68e-11 63.9 COG4191@1|root,COG4191@2|Bacteria,2IZY8@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_39675_1 1232410.KI421425_gene1550 1.33e-149 439.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_140895_1 335543.Sfum_2316 1.89e-58 196.0 COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,42TEX@68525|delta/epsilon subdivisions,2WPG8@28221|Deltaproteobacteria,2MRKZ@213462|Syntrophobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_166770_1 1341157.RF007C_09070 3.72e-29 124.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3WGNQ@541000|Ruminococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_70262_1 335543.Sfum_1120 8.36e-43 157.0 COG2202@1|root,COG3829@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,HisKA_2,PAS,PAS_4,PAS_9,dCache_1 k59_24712_1 349521.HCH_03995 5.24e-51 166.0 2C0IR@1|root,300P8@2|Bacteria,1N4KZ@1224|Proteobacteria,1SRYZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4288) - - - - - - - - - - - - DUF4288 k59_134779_1 768066.HELO_2329 3.37e-112 335.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1XI8P@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_108936_1 706587.Desti_1392 4.19e-78 246.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,2MRUB@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_166771_1 743299.Acife_1617 5.15e-21 86.3 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,1S9F8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin - - - - - - - - - - - - - k59_166771_2 395493.BegalDRAFT_0175 1.06e-53 174.0 COG0457@1|root,COG0457@2|Bacteria,1RC44@1224|Proteobacteria,1SCGV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_70263_1 870187.Thini_0800 8.78e-132 386.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_11703_3 1122182.KB903819_gene194 1.06e-70 244.0 COG2706@1|root,COG3227@1|root,COG2706@2|Bacteria,COG3227@2|Bacteria,2IDQA@201174|Actinobacteria,4DBCS@85008|Micromonosporales 201174|Actinobacteria E Thermolysin metallopeptidase, catalytic domain - - - - - - - - - - - - FTP,P_proprotein,Peptidase_M4,Peptidase_M4_C k59_187053_2 1229205.BUPH_06246 1.03e-18 84.3 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,1K1SY@119060|Burkholderiaceae 28216|Betaproteobacteria S abc transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_115052_1 1123504.JQKD01000016_gene1960 9.01e-06 50.1 29Q66@1|root,30B54@2|Bacteria,1N9YZ@1224|Proteobacteria,2VUIM@28216|Betaproteobacteria,4AHAV@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4166) - - - - - - - - - - - - DUF4166 k59_115052_2 305900.GV64_20555 1.55e-14 72.4 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XIBT@135619|Oceanospirillales 135619|Oceanospirillales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_56211_1 1121434.AULY01000013_gene66 1.9e-22 96.7 COG0727@1|root,COG0727@2|Bacteria,1RIJV@1224|Proteobacteria,42U8U@68525|delta/epsilon subdivisions,2WPB4@28221|Deltaproteobacteria,2MBWG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_56211_2 522373.Smlt1575 3.33e-10 62.4 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,1RNJA@1236|Gammaproteobacteria,1X4QB@135614|Xanthomonadales 135614|Xanthomonadales T Diguanylate cyclase rrpX - - - - - - - - - - - GGDEF,Response_reg k59_166775_1 1550073.JROH01000065_gene2799 6.73e-47 161.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,2K002@204457|Sphingomonadales 204457|Sphingomonadales M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_166775_2 1131269.AQVV01000004_gene584 3.66e-37 130.0 COG1898@1|root,COG1898@2|Bacteria 2|Bacteria M dTDP-4-dehydrorhamnose 3,5-epimerase activity rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_17351_2 1249627.D779_2236 3.13e-131 380.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1WXAU@135613|Chromatiales 135613|Chromatiales U Belongs to the peptidase S26 family - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_89194_2 96561.Dole_1931 8.89e-31 120.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MI1J@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like k59_96591_1 911045.PSE_0624 3.47e-18 84.7 COG1502@1|root,COG1502@2|Bacteria,1N9CD@1224|Proteobacteria 1224|Proteobacteria I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_96591_2 472759.Nhal_0297 2.17e-47 156.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,1SAI5@1236|Gammaproteobacteria,1WYMJ@135613|Chromatiales 135613|Chromatiales K PFAM Bacterial regulatory protein, arsR family - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_96591_3 1249627.D779_2579 6.55e-171 483.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria,1WX27@135613|Chromatiales 135613|Chromatiales S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_96591_4 572477.Alvin_1532 9.47e-37 125.0 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,1SCEC@1236|Gammaproteobacteria,1WZIE@135613|Chromatiales 135613|Chromatiales CO TIGRFAM small redox-active disulfide protein 2 - - - - - - - - - - - - Thioredoxin_3 k59_82884_2 1049564.TevJSym_aq00070 4.67e-171 489.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1J70K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Dimerisation domain of Zinc Transporter fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_82884_4 1049564.TevJSym_aq00090 8.98e-205 572.0 COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria 1236|Gammaproteobacteria J tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain - - - - - - - - - - - - ThiI,tRNA_Me_trans k59_82884_5 1049564.TevJSym_aq00100 2.77e-98 292.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1J50F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J glycyl-tRNA synthetase, alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_56212_1 7159.AAEL011502-PA 3.17e-06 55.1 KOG0154@1|root,KOG0154@2759|Eukaryota,39TV0@33154|Opisthokonta,3BEIS@33208|Metazoa,3D1WJ@33213|Bilateria,41XCN@6656|Arthropoda,3SHFW@50557|Insecta,45269@7147|Diptera,45BJQ@7148|Nematocera 33208|Metazoa S glycine rich nucleic binding domain AGGF1 GO:0000375,GO:0000377,GO:0000398,GO:0001568,GO:0001570,GO:0001936,GO:0001938,GO:0001944,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005681,GO:0005737,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0007155,GO:0007275,GO:0008150,GO:0008152,GO:0008284,GO:0008380,GO:0009653,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0022603,GO:0022610,GO:0030154,GO:0032501,GO:0032502,GO:0032991,GO:0034641,GO:0035239,GO:0035295,GO:0042127,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045765,GO:0045766,GO:0046483,GO:0048471,GO:0048514,GO:0048518,GO:0048522,GO:0048731,GO:0048856,GO:0048869,GO:0050678,GO:0050679,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051239,GO:0051240,GO:0065007,GO:0071011,GO:0071704,GO:0072358,GO:0072359,GO:0090304,GO:1901342,GO:1901360,GO:1904018,GO:1990904,GO:2000026 - - - - - - - - - - FHA,G-patch k59_30776_1 380394.Lferr_0291 7.73e-59 187.0 COG5350@1|root,COG5350@2|Bacteria 2|Bacteria - - MA20_42125 - - - - - - - - - - - DSPc,Y_phosphatase k59_30776_2 572477.Alvin_3094 6.73e-130 397.0 COG3344@1|root,COG3344@2|Bacteria,1RD41@1224|Proteobacteria,1SASD@1236|Gammaproteobacteria,1WZT3@135613|Chromatiales 135613|Chromatiales L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_122517_1 118161.KB235922_gene5902 7.3e-11 70.1 COG2133@1|root,COG2373@1|root,COG2133@2|Bacteria,COG2373@2|Bacteria,1G2CB@1117|Cyanobacteria,3VM5E@52604|Pleurocapsales 1117|Cyanobacteria GQ Glucose Sorbosone dehydrogenase - - - - - - - - - - - - Calx-beta,DUF4347,GSDH,PA14 k59_187055_1 1049564.TevJSym_ab00220 9.45e-28 113.0 2DS2H@1|root,33E82@2|Bacteria,1NPEB@1224|Proteobacteria,1SRXB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_45021_1 1397528.Q671_08895 2.01e-14 73.2 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria,1XQYS@135619|Oceanospirillales 135619|Oceanospirillales M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_45021_2 398720.MED217_12439 3.48e-19 80.9 2EPEC@1|root,33H0Y@2|Bacteria,4P4SQ@976|Bacteroidetes,1I9R8@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_63656_2 1458275.AZ34_11980 1.1e-48 169.0 COG4748@1|root,COG4748@2|Bacteria,1MXDA@1224|Proteobacteria,2VM6R@28216|Betaproteobacteria,4AGNJ@80864|Comamonadaceae 28216|Betaproteobacteria L Type I restriction enzyme R protein N terminus (HSDR_N) - - - ko:K07504 - - - - ko00000 - - - HSDR_N,HSDR_N_2 k59_128971_1 1502851.FG93_04099 3.44e-05 51.6 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2TV1B@28211|Alphaproteobacteria,3JRSV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria N Belongs to the flagella basal body rod proteins family flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_96600_1 1117314.PCIT_21099 1.08e-40 142.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,2Q2K2@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB GO:0003674,GO:0003824,GO:0006091,GO:0006457,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0022900,GO:0044237,GO:0050896,GO:0055114 - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - iAF1260.b1185,iB21_1397.B21_01170,iBWG_1329.BWG_1010,iEC042_1314.EC042_1234,iEC55989_1330.EC55989_1280,iECBD_1354.ECBD_2437,iECB_1328.ECB_01160,iECDH10B_1368.ECDH10B_1238,iECDH1ME8569_1439.ECDH1ME8569_1124,iECD_1391.ECD_01160,iECED1_1282.ECED1_1327,iECIAI1_1343.ECIAI1_1202,iECO103_1326.ECO103_1287,iECSP_1301.ECSP_1582,iECUMN_1333.ECUMN_1474,iECs_1301.ECs1680,iETEC_1333.ETEC_1289,iEcDH1_1363.EcDH1_2463,iEcHS_1320.EcHS_A1288,iEcSMS35_1347.EcSMS35_1964,iEcolC_1368.EcolC_2440,iG2583_1286.G2583_1446,iJO1366.b1185,iSDY_1059.SDY_1222,iY75_1357.Y75_RS06185 DsbB k59_101849_2 35703.DQ02_06185 1.06e-78 244.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,1RSM9@1236|Gammaproteobacteria,3WY32@544|Citrobacter 1236|Gammaproteobacteria P Eukaryotic-type carbonic anhydrase cah - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase k59_101849_3 1415778.JQMM01000001_gene634 2.14e-107 315.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1J4ME@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_37741_1 572477.Alvin_1047 5.53e-137 399.0 COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_75896_1 1307759.JOMJ01000003_gene257 2.64e-40 152.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_166788_1 768671.ThimaDRAFT_2688 2.75e-66 209.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1WXNV@135613|Chromatiales 135613|Chromatiales C cytochrome - - - - - - - - - - - - Ni_hydr_CYTB k59_70288_1 335543.Sfum_3649 4.38e-118 354.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales 28221|Deltaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_160770_1 926550.CLDAP_04870 2.56e-25 116.0 COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi 200795|Chloroflexi G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_134805_1 768710.DesyoDRAFT_3702 1.48e-69 213.0 COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia 186801|Clostridia S THIoesterase - - 3.1.2.29 ko:K18700 - - - - ko00000,ko01000 - - - 4HBT k59_187068_2 1001530.BACE01000015_gene1433 2.08e-09 56.6 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1XYEQ@135623|Vibrionales 135623|Vibrionales J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006109,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016071,GO:0019222,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_128977_1 96561.Dole_0012 3.83e-07 56.2 COG5616@1|root,COG5616@2|Bacteria,1RBBE@1224|Proteobacteria,42QR8@68525|delta/epsilon subdivisions,2WN1X@28221|Deltaproteobacteria,2MHSI@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Curli production assembly transport component CsgG - - - - - - - - - - - - CsgG,VCBS k59_128977_2 439235.Dalk_1786 4.6e-58 187.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2MIR6@213118|Desulfobacterales 28221|Deltaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_140928_1 1388763.O165_006355 1.16e-27 115.0 COG0582@1|root,COG0582@2|Bacteria,1QN5P@1224|Proteobacteria,1TKKP@1236|Gammaproteobacteria,1YX2T@136845|Pseudomonas putida group 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_140928_4 1121935.AQXX01000137_gene3938 2.07e-16 81.3 COG0503@1|root,COG0503@2|Bacteria 2|Bacteria F purine ribonucleoside salvage apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_56221_1 1042377.AFPJ01000007_gene1810 5.09e-130 380.0 COG4974@1|root,COG4974@2|Bacteria,1PZTE@1224|Proteobacteria,1RPTV@1236|Gammaproteobacteria,4663A@72275|Alteromonadaceae 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_173176_1 1265505.ATUG01000002_gene2238 6.21e-53 173.0 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42RKH@68525|delta/epsilon subdivisions,2WPJZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase k59_56373_1 1123393.KB891332_gene2734 2.13e-33 116.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2VW5V@28216|Betaproteobacteria,1KRS0@119069|Hydrogenophilales 119069|Hydrogenophilales J Ribosomal protein L31 - - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_56373_2 911239.CF149_09628 6.56e-40 148.0 COG1525@1|root,COG1525@2|Bacteria,1RKRQ@1224|Proteobacteria,1S5D6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nuclease - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - DUF4124,SNase k59_109195_1 1499967.BAYZ01000088_gene5063 1.77e-135 391.0 COG1313@1|root,COG1313@2|Bacteria,2NP6I@2323|unclassified Bacteria 2|Bacteria C Radical SAM superfamily PflX - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_56374_1 886293.Sinac_5724 8.33e-05 45.4 COG0662@1|root,COG0662@2|Bacteria,2J0CV@203682|Planctomycetes 203682|Planctomycetes G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_56374_2 1249627.D779_4007 4.61e-17 77.8 COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,1S17V@1236|Gammaproteobacteria,1WWE8@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_147900_1 1198232.CYCME_1857 1.14e-05 46.6 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,4613P@72273|Thiotrichales 72273|Thiotrichales O Glycoprotease family yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_147900_2 1049564.TevJSym_aa02020 1.96e-91 295.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J7FH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_160954_2 1168065.DOK_09631 2.44e-229 638.0 COG4924@1|root,COG4924@2|Bacteria,1P11B@1224|Proteobacteria,1RYWN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2220,DUF3322 k59_160954_3 1168065.DOK_09626 0.0 1886.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RPTX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - AAA_29,SbcCD_C k59_160954_4 1168065.DOK_09621 1.25e-121 351.0 2BW5S@1|root,2Z8JM@2|Bacteria,1R3MV@1224|Proteobacteria,1S1QY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4194) - - - - - - - - - - - - DUF4194 k59_160954_5 1168065.DOK_09611 5.08e-288 794.0 COG4942@1|root,COG4942@2|Bacteria,1MXRZ@1224|Proteobacteria,1RR9E@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Protein of unknown function (DUF3375) - - - - - - - - - - - - DUF3375 k59_160954_6 1122201.AUAZ01000004_gene3446 3.35e-19 83.6 COG5340@1|root,COG5340@2|Bacteria,1R1GM@1224|Proteobacteria,1S2NC@1236|Gammaproteobacteria,468ZG@72275|Alteromonadaceae 1236|Gammaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEi_4 k59_160954_8 1122201.AUAZ01000004_gene3398 4.6e-12 63.2 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1SA7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_160954_9 1123401.JHYQ01000003_gene2026 3.53e-18 84.0 COG0210@1|root,COG0666@1|root,COG0210@2|Bacteria,COG0666@2|Bacteria,1R4JW@1224|Proteobacteria,1RMH6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase - - - - - - - - - - - - Ank_5,UvrD-helicase,Viral_helicase1 k59_160954_10 1123401.JHYQ01000003_gene2026 1.14e-24 103.0 COG0210@1|root,COG0666@1|root,COG0210@2|Bacteria,COG0666@2|Bacteria,1R4JW@1224|Proteobacteria,1RMH6@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase - - - - - - - - - - - - Ank_5,UvrD-helicase,Viral_helicase1 k59_160954_11 382464.ABSI01000011_gene3165 3.78e-174 523.0 COG0553@1|root,COG0553@2|Bacteria,46U9A@74201|Verrucomicrobia,2ITYK@203494|Verrucomicrobiae 203494|Verrucomicrobiae L SNF2 Helicase protein - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - DUF3670,Helicase_C,SNF2_N k59_63851_1 314345.SPV1_12360 1.78e-93 284.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_154071_1 335543.Sfum_2713 5.14e-110 331.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR9E@213462|Syntrophobacterales 28221|Deltaproteobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region hoxF - 1.6.5.3 ko:K00124,ko:K00335,ko:K05587 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_76101_1 338963.Pcar_2514 1.85e-11 71.2 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,43SV4@69541|Desulfuromonadales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_173180_1 768671.ThimaDRAFT_4175 2.4e-174 513.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_38021_2 1117647.M5M_07445 8.76e-24 99.4 COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,1T2BY@1236|Gammaproteobacteria,1J687@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_38021_4 1121861.KB899945_gene3971 9.48e-111 341.0 COG4249@1|root,COG4249@2|Bacteria 2|Bacteria S B-1 B cell differentiation - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - FGE-sulfatase,GUN4,Peptidase_C14,WD40 k59_38021_5 1120999.JONM01000011_gene1606 6.07e-146 419.0 COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2VHB1@28216|Betaproteobacteria,2KQTX@206351|Neisseriales 206351|Neisseriales K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate k59_180286_1 1123511.KB905872_gene1845 2.55e-115 343.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H53T@909932|Negativicutes 909932|Negativicutes L RNA-directed DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_129183_1 1121405.dsmv_1104 6.52e-96 290.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2MIZI@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_147907_1 870187.Thini_0218 9.02e-120 362.0 COG4988@1|root,COG4988@2|Bacteria,1QU1N@1224|Proteobacteria,1RNPI@1236|Gammaproteobacteria,460CF@72273|Thiotrichales 72273|Thiotrichales V ATP-binding protein cydD - - ko:K16013 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran k59_102078_1 536227.CcarbDRAFT_3357 1.09e-24 101.0 COG0500@1|root,COG2226@2|Bacteria,1V6EF@1239|Firmicutes,24JZ4@186801|Clostridia,36J18@31979|Clostridiaceae 186801|Clostridia Q Mycolic acid cyclopropane synthetase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_122770_1 288000.BBta_6812 1.18e-19 96.3 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,3JQV9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_143616_2 765911.Thivi_0897 1.34e-232 664.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,1RNZU@1236|Gammaproteobacteria,1WXEZ@135613|Chromatiales 135613|Chromatiales K PFAM Ribonuclease II - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_143616_3 1049564.TevJSym_al00270 3.23e-137 399.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1J62T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S aminomethyltransferase related to GcvT ygfZ GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_143616_4 1049564.TevJSym_al00280 1.3e-18 83.2 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1J4P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_117741_1 1049564.TevJSym_ad01320 2.48e-188 533.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,1J5M2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S A domain family that is part of the cupin metalloenzyme superfamily. ycfD GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_117741_2 1049564.TevJSym_ad01330 1.22e-128 377.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1J4V5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_130739_1 203124.Tery_4303 1.08e-13 76.3 COG3391@1|root,COG4932@1|root,COG5276@1|root,COG3391@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria 2|Bacteria M domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CHU_C,Gram_pos_anchor,MucBP,SLH k59_39876_1 439235.Dalk_3029 5.65e-162 482.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WM1R@28221|Deltaproteobacteria,2MID5@213118|Desulfobacterales 28221|Deltaproteobacteria KL SNF2 Helicase protein - - - - - - - - - - - - DUF3670,Helicase_C,SNF2_N k59_39876_2 335283.Neut_2180 2.62e-77 246.0 COG4279@1|root,COG4279@2|Bacteria,1N5C3@1224|Proteobacteria,2WBCS@28216|Betaproteobacteria,374I5@32003|Nitrosomonadales 28216|Betaproteobacteria S Zinc finger SWIM domain protein - - - - - - - - - - - - - k59_39876_3 192952.MM_2981 1.41e-12 67.4 COG0286@1|root,arCOG05282@2157|Archaea,2Y89X@28890|Euryarchaeota,2NAPP@224756|Methanomicrobia 224756|Methanomicrobia V HsdM N-terminal domain - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_39876_4 1454004.AW11_01762 7.85e-53 201.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPV5@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_39876_5 522373.Smlt1868 1.84e-26 108.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,1RZZW@1236|Gammaproteobacteria,1X588@135614|Xanthomonadales 135614|Xanthomonadales OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_169579_1 211586.SO_3101 1.74e-61 197.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,2Q9QB@267890|Shewanellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_163072_1 90814.KL370891_gene1761 1.03e-27 113.0 COG3064@1|root,COG3064@2|Bacteria,1MZUF@1224|Proteobacteria,1S95Z@1236|Gammaproteobacteria,462M5@72273|Thiotrichales 72273|Thiotrichales M SprA-related family - - - - - - - - - - - - SprA-related k59_13816_1 1530186.JQEY01000001_gene1278 3.62e-29 111.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TTR3@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_13816_2 1121403.AUCV01000010_gene1382 3.62e-134 389.0 COG1116@1|root,COG1116@2|Bacteria,1MWZG@1224|Proteobacteria,43CBE@68525|delta/epsilon subdivisions 1224|Proteobacteria P ABC transporter cysA_3 - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_13816_5 177437.HRM2_26190 9.74e-53 180.0 COG0491@1|root,COG0491@2|Bacteria,1Q2C2@1224|Proteobacteria,42RVX@68525|delta/epsilon subdivisions,2WNQR@28221|Deltaproteobacteria,2MK0Q@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_163076_1 1248232.BANQ01000086_gene2791 1.3e-15 71.6 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1XXVE@135623|Vibrionales 135623|Vibrionales S Belongs to the UPF0235 family yggU - - ko:K09131 - - - - ko00000 - - - DUF167 k59_163076_2 1049564.TevJSym_am00180 1.97e-51 168.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_104647_2 555778.Hneap_0557 5.38e-81 247.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,1S93K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Rhodanese,Sulf_transp k59_104647_3 555778.Hneap_0556 4.52e-61 194.0 COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,1SANT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_104647_4 160488.PP_0245 1.87e-33 130.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1YWD9@136845|Pseudomonas putida group 1236|Gammaproteobacteria K SMART Resolvase, RNase H domain protein fold yhgF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_78993_1 1408422.JHYF01000006_gene1191 4.84e-23 99.0 COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae 186801|Clostridia C Aldehyde ferredoxin oxidoreductase aor - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS09915 AFOR_C,AFOR_N k59_52872_1 1231241.Mc24_06638 6.29e-14 75.9 COG0582@1|root,COG0582@2|Bacteria,2GDJZ@200918|Thermotogae 200918|Thermotogae L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_integrase k59_156699_1 555779.Dthio_PD1033 2.94e-51 181.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MH87@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_46452_1 1049564.TevJSym_ab00200 1.46e-70 221.0 COG2227@1|root,COG2227@2|Bacteria,1NN3B@1224|Proteobacteria,1T1TQ@1236|Gammaproteobacteria,1JC06@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 k59_46452_4 498211.CJA_0237 3.92e-92 283.0 COG1520@1|root,COG1520@2|Bacteria,1R0KY@1224|Proteobacteria 1224|Proteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_46452_5 1049564.TevJSym_ab00210 9.81e-157 449.0 COG0726@1|root,COG0726@2|Bacteria,1RA45@1224|Proteobacteria,1S2JF@1236|Gammaproteobacteria 1236|Gammaproteobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_46452_7 1121406.JAEX01000010_gene1316 9.42e-07 50.1 COG1765@1|root,COG1765@2|Bacteria,1QF2G@1224|Proteobacteria,42UVN@68525|delta/epsilon subdivisions,2WQVS@28221|Deltaproteobacteria,2MCWI@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM OsmC family protein - - - - - - - - - - - - OsmC k59_13928_1 1304885.AUEY01000018_gene1108 1.45e-55 193.0 COG1208@1|root,COG4857@1|root,COG1208@2|Bacteria,COG4857@2|Bacteria,1R1X2@1224|Proteobacteria,43DC4@68525|delta/epsilon subdivisions,2WVQJ@28221|Deltaproteobacteria,2MPP2@213118|Desulfobacterales 28221|Deltaproteobacteria JM Phosphotransferase enzyme family - - - - - - - - - - - - APH,NTP_transferase k59_72410_1 1121440.AUMA01000018_gene2030 4.38e-96 285.0 COG3676@1|root,COG3676@2|Bacteria,1R7ZF@1224|Proteobacteria,436XG@68525|delta/epsilon subdivisions,2X1MQ@28221|Deltaproteobacteria,2MFBF@213115|Desulfovibrionales 28221|Deltaproteobacteria L ISXO2-like transposase domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595 k59_79146_1 765912.Thimo_1205 1.22e-108 316.0 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1WY0V@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_79146_2 929558.SMGD1_2506 2.78e-21 87.4 COG3205@1|root,COG3205@2|Bacteria,1NA8W@1224|Proteobacteria,42WKV@68525|delta/epsilon subdivisions,2YQBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted membrane protein (DUF2061) - - - - - - - - - - - - DUF2061 k59_79146_4 722419.PH505_af00400 4.84e-20 89.0 COG0840@1|root,COG0840@2|Bacteria,1QWU2@1224|Proteobacteria,1T560@1236|Gammaproteobacteria,2Q5J1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NT transmembrane signaling receptor activity - - - - - - - - - - - - - k59_972_1 925409.KI911562_gene109 3.26e-20 95.9 COG0472@1|root,COG0472@2|Bacteria,4NE0T@976|Bacteroidetes,1IQU9@117747|Sphingobacteriia 976|Bacteroidetes M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_7693_1 1121441.AUCX01000025_gene1678 1.74e-18 85.5 COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria,2MC69@213115|Desulfovibrionales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_150351_1 56780.SYN_01414 1.78e-18 88.6 COG0457@1|root,COG0457@2|Bacteria,1MZGK@1224|Proteobacteria,436UH@68525|delta/epsilon subdivisions,2X2DU@28221|Deltaproteobacteria,2MS3X@213462|Syntrophobacterales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 k59_33556_1 1049564.TevJSym_ap00510 9.35e-207 589.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_33556_2 1266925.JHVX01000013_gene1661 8.33e-46 149.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2VSDV@28216|Betaproteobacteria,373AA@32003|Nitrosomonadales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_33556_3 1049564.TevJSym_ap00530 2.65e-82 249.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S4ZA@1236|Gammaproteobacteria,1JBRZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_33556_4 717773.Thicy_0645 1.12e-15 72.8 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,460DI@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_85371_1 1121106.JQKB01000001_gene3160 1.55e-07 53.5 COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,2JQYQ@204441|Rhodospirillales 204441|Rhodospirillales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_53027_3 626887.J057_01705 5.45e-07 50.8 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,1RZ7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_65905_1 457570.Nther_0276 6.08e-27 114.0 COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia 186801|Clostridia P Transporter, CPA2 family - - - - - - - - - - - - Na_H_Exchanger k59_91907_1 768671.ThimaDRAFT_3913 2e-102 328.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1WWR1@135613|Chromatiales 135613|Chromatiales KL DNA RNA helicase - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_977_1 1123400.KB904746_gene1154 1.1e-09 57.8 COG0208@1|root,COG1372@1|root,COG0208@2|Bacteria,COG1372@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,45ZQV@72273|Thiotrichales 72273|Thiotrichales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526,ko:K03676 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03110,ko03400 - - - Glutaredoxin,Ribonuc_red_sm k59_143818_1 1121451.DESAM_22464 3.38e-65 219.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2M9TK@213115|Desulfovibrionales 28221|Deltaproteobacteria C Fe-S cluster domain protein - - - - - - - - - - - - FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_104793_1 264402.Cagra.0007s0085.1.p 9.73e-32 117.0 COG0526@1|root,KOG0910@2759|Eukaryota,37UUM@33090|Viridiplantae,3GIDN@35493|Streptophyta,3HZMF@3699|Brassicales 35493|Streptophyta O Thioredoxin - GO:0003674,GO:0003824,GO:0004791,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006109,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009636,GO:0009719,GO:0009725,GO:0009735,GO:0009941,GO:0009987,GO:0010033,GO:0015035,GO:0015036,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019222,GO:0019725,GO:0019904,GO:0030234,GO:0030312,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0033554,GO:0034357,GO:0034599,GO:0042221,GO:0042592,GO:0042651,GO:0043085,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044092,GO:0044093,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051716,GO:0055035,GO:0055114,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071944,GO:0080090,GO:0097237,GO:0098754,GO:0098772,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_137187_1 1242864.D187_007140 1.24e-39 147.0 COG0189@1|root,COG0189@2|Bacteria,1QX79@1224|Proteobacteria,42P6H@68525|delta/epsilon subdivisions,2WKP1@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ ATP-grasp domain - - - - - - - - - - - - ATP-grasp_3 k59_53035_1 1265505.ATUG01000002_gene1665 1.18e-22 95.1 COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2MNDC@213118|Desulfobacterales 28221|Deltaproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 k59_169807_1 525904.Tter_0289 6.38e-35 133.0 COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria 2|Bacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494 6.2.1.5,6.2.1.9 ko:K01903,ko:K14067 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261,iPC815.YPO1115,iUMNK88_1353.UMNK88_764,iYO844.BSU16090 ATP-grasp_2,Ligase_CoA k59_189213_1 565045.NOR51B_313 5.37e-91 276.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,1RTU6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_189213_2 573.JG24_20795 1.7e-46 157.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,1RMHT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the aspartate glutamate racemases family ygeA GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_40092_1 1304885.AUEY01000046_gene9 3.69e-77 249.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria,2MHZ9@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II secretion system pulE-3 - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_33567_1 1121405.dsmv_1738 2.99e-71 218.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2WNA5@28221|Deltaproteobacteria,2MK12@213118|Desulfobacterales 28221|Deltaproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_46474_1 644282.Deba_1058 8.48e-23 96.7 COG0463@1|root,COG0463@2|Bacteria,1R547@1224|Proteobacteria,42PDC@68525|delta/epsilon subdivisions,2WKYW@28221|Deltaproteobacteria 28221|Deltaproteobacteria M glycosyl transferase family 2 - - 2.4.1.268 ko:K21349 - - - - ko00000,ko01000 - GT81 - Glycos_transf_2 k59_46474_2 335543.Sfum_0187 6.72e-66 202.0 COG0745@1|root,COG0745@2|Bacteria,1N3R6@1224|Proteobacteria,42TU3@68525|delta/epsilon subdivisions,2WQN0@28221|Deltaproteobacteria,2MRWN@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_176163_2 1236000.L0AQZ2_9CAUD 1.8e-39 137.0 4QEGD@10239|Viruses,4QVU1@35237|dsDNA viruses no RNA stage,4QPN9@28883|Caudovirales,4QJCM@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_20546_2 1537994.JQFW01000002_gene3453 9.47e-16 72.4 2CQDU@1|root,32SKZ@2|Bacteria,1N111@1224|Proteobacteria,1SH0Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Antitoxin ParD parD - - - - - - - - - - - ParD k59_20546_3 1129374.AJE_07256 1.06e-25 97.8 COG3668@1|root,COG3668@2|Bacteria,1RKAK@1224|Proteobacteria,1SD8T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_20546_4 2340.JV46_25240 3.65e-48 160.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RXB4@1236|Gammaproteobacteria,1JAMN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - - - - - - - - - - - LexA_DNA_bind,Peptidase_S24 k59_98244_1 589865.DaAHT2_0736 6.32e-52 185.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_49333_1 396588.Tgr7_3127 8.04e-104 311.0 COG3203@1|root,COG3203@2|Bacteria,1RF3Y@1224|Proteobacteria 1224|Proteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_95480_1 545243.BAEV01000008_gene1210 1.42e-56 196.0 COG4644@1|root,COG4644@2|Bacteria,1UZ13@1239|Firmicutes,24FFD@186801|Clostridia,36VYT@31979|Clostridiaceae 186801|Clostridia L Domain of unknown function (DUF4158) - - - - - - - - - - - - DDE_Tnp_Tn3,DUF4158 k59_121189_1 640081.Dsui_1230 4.39e-38 142.0 COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,2KVEI@206389|Rhodocyclales 206389|Rhodocyclales S NMT1-like family - - - - - - - - - - - - NMT1_3 k59_100758_1 1049564.TevJSym_ag01090 0.0 971.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_43734_1 1049564.TevJSym_aw00130 1.31e-42 151.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_43734_2 1049564.TevJSym_aw00120 1.33e-123 372.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster dsrL - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2 k59_107715_1 1049564.TevJSym_as00020 7.37e-34 135.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_74801_1 1366050.N234_01090 2.09e-93 286.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2WEZH@28216|Betaproteobacteria 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_121340_2 765912.Thimo_0218 1.06e-17 79.3 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1WYHV@135613|Chromatiales 135613|Chromatiales T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_62696_1 1049564.TevJSym_ad01490 2.21e-105 320.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1J51F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766 - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_191984_5 2340.JV46_08350 9.01e-91 273.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1S2ZN@1236|Gammaproteobacteria,1J733@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family exbB2 - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_69104_1 631362.Thi970DRAFT_01084 5.6e-74 243.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales 135613|Chromatiales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_127959_1 671143.DAMO_0069 1.49e-46 164.0 COG1373@1|root,COG1373@2|Bacteria,2NP9F@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4143) - - - - - - - - - - - - AAA_14,DUF4143 k59_179215_1 933262.AXAM01000039_gene1151 2.79e-21 89.0 COG3087@1|root,COG3087@2|Bacteria 2|Bacteria D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - ko:K03591 - - - - ko00000,ko03036 - - - NYN,SPOR k59_179215_2 1384057.CD33_05475 1.18e-17 78.2 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,3IYC1@400634|Lysinibacillus 91061|Bacilli F Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_179215_3 555079.Toce_0656 4.17e-07 51.2 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,42EXF@68295|Thermoanaerobacterales 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_165848_1 243231.GSU3451 5.99e-26 105.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WRBS@28221|Deltaproteobacteria,43VRI@69541|Desulfuromonadales 28221|Deltaproteobacteria S Alpha/beta hydrolase family - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_62703_1 933262.AXAM01000039_gene1153 2.18e-99 303.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_159743_3 573061.Clocel_0442 7.55e-46 156.0 COG0693@1|root,COG0693@2|Bacteria,1UDUN@1239|Firmicutes,24Y5U@186801|Clostridia,36U4E@31979|Clostridiaceae 2|Bacteria S PFAM ThiJ PfpI domain-containing protein - - 3.5.1.124 ko:K03152,ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI,ThiJ_like k59_133871_1 1049564.TevJSym_ah00750 6.64e-34 123.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1JB7N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_186034_1 439235.Dalk_1208 1.48e-79 256.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_36712_1 555779.Dthio_PD3813 1.88e-08 56.6 COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2M8S3@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM RNA binding S1 domain protein - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_127967_1 706587.Desti_2540 1.36e-83 256.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MREB@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM thiamine pyrophosphate enzyme - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_121343_1 1121035.AUCH01000008_gene1008 6.34e-54 186.0 29M87@1|root,3085U@2|Bacteria,1RFIW@1224|Proteobacteria,2W1JP@28216|Betaproteobacteria,2KY77@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_16476_2 471223.GWCH70_2396 3.67e-24 106.0 COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,4HBEB@91061|Bacilli,1WF3G@129337|Geobacillus 91061|Bacilli P PBP superfamily domain pstS GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_16476_3 472759.Nhal_0236 2.77e-117 348.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1WVZX@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_16476_4 713586.KB900536_gene625 4.61e-72 230.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales 135613|Chromatiales L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_81972_1 298386.PBPRB0577 3.43e-21 102.0 2DBPZ@1|root,2ZABJ@2|Bacteria,1R7CU@1224|Proteobacteria,1SKX7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_74926_1 2340.JV46_08070 7.71e-229 643.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1J54W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_107881_1 909663.KI867150_gene863 2.86e-146 434.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2WJ4X@28221|Deltaproteobacteria,2MQ64@213462|Syntrophobacterales 28221|Deltaproteobacteria K Tex-like protein N-terminal domain tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_127971_1 671143.DAMO_1148 7.24e-102 308.0 COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria 2|Bacteria BQ Histone deacetylase domain acuC - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_49484_1 1196083.SALWKB12_0531 4.62e-44 155.0 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria 1224|Proteobacteria U Large exoproteins involved in heme utilization or adhesion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Fil_haemagg_2,Haemagg_act,PT-VENN k59_49484_2 291112.PAU_03360 6.46e-30 111.0 2E13J@1|root,32WIZ@2|Bacteria,1N6F6@1224|Proteobacteria,1SNQV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_49484_3 1219077.VAZ01S_012_00350 2.83e-81 246.0 COG1859@1|root,COG1859@2|Bacteria,1RD8B@1224|Proteobacteria,1S3U6@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase kptA GO:0003674,GO:0003824,GO:0016740,GO:0016772 - ko:K07559 - - - - ko00000,ko01000,ko03016 - - - PTS_2-RNA k59_121352_1 1538295.JY96_04860 1.59e-12 73.2 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,1KJ25@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Type II secretory pathway, component ExeA exeA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_81975_1 70601.3258436 8.79e-31 114.0 COG1586@1|root,arCOG00279@2157|Archaea,2XYBE@28890|Euryarchaeota,243ZV@183968|Thermococci 183968|Thermococci E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_153022_1 392500.Swoo_0776 3.94e-85 274.0 COG0369@1|root,COG0369@2|Bacteria,1QUAH@1224|Proteobacteria,1T1RJ@1236|Gammaproteobacteria,2Q8RU@267890|Shewanellaceae 1236|Gammaproteobacteria C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009337,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0032991,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - iECO26_1355.ECO26_3835,iECSE_1348.ECSE_3020,iECW_1372.ECW_m2972,iEKO11_1354.EKO11_1004,iEcE24377_1341.EcE24377A_3066,iEcolC_1368.EcolC_0948,iWFL_1372.ECW_m2972 FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_165853_2 1049564.TevJSym_au00150 3.92e-78 238.0 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,1S9YH@1236|Gammaproteobacteria,1J6NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - DnaJ,HSCB_C k59_10705_1 671143.DAMO_3090 5.65e-16 73.6 2DGRB@1|root,2ZX02@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_74929_1 396588.Tgr7_2406 7.31e-50 175.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales 135613|Chromatiales M PFAM peptidase - - - - - - - - - - - - OapA,Peptidase_M23 k59_114101_1 492774.JQMB01000009_gene3465 0.0 884.0 COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2TTAB@28211|Alphaproteobacteria,4B8DW@82115|Rhizobiaceae 28211|Alphaproteobacteria F Xanthine dehydrogenase xdhB - 1.17.1.4 ko:K13482 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_114101_2 1041142.ATTP01000001_gene2093 1.6e-113 335.0 COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,2TU5J@28211|Alphaproteobacteria,4B7Q8@82115|Rhizobiaceae 28211|Alphaproteobacteria O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_107885_1 96561.Dole_3250 1.93e-56 191.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_192003_1 1173023.KE650771_gene5577 3.66e-219 614.0 COG3344@1|root,COG3344@2|Bacteria,1G4U8@1117|Cyanobacteria 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,HNH,RVT_1 k59_139814_1 506534.Rhein_1855 1.01e-06 54.3 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales 135613|Chromatiales G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_198020_1 232346.JHQL01000006_gene3009 1.36e-19 92.8 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XHYC@135619|Oceanospirillales 135619|Oceanospirillales L recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_146685_1 224308.BSU03440 1.09e-09 67.8 COG0840@1|root,COG3290@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus 91061|Bacilli NT chemotaxis protein tlpC - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_3_3 k59_127978_1 96561.Dole_0036 4.03e-63 206.0 COG3018@1|root,COG3018@2|Bacteria,1R9S8@1224|Proteobacteria,42RI7@68525|delta/epsilon subdivisions,2WP0N@28221|Deltaproteobacteria,2MIVN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - LPP20 k59_95642_1 1049564.TevJSym_ag01070 3.18e-73 232.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1J5T7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria LU Rossmann fold nucleotide-binding protein involved in DNA uptake smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_62717_1 1454004.AW11_01265 1.27e-22 97.1 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria 28216|Betaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS k59_62717_3 1049564.TevJSym_aj00480 6.38e-128 377.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1J5ND@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0277 FAD FMN-containing dehydrogenases dld - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_36728_1 1127673.GLIP_3386 9.82e-23 94.7 2AD08@1|root,312N7@2|Bacteria,1NDC4@1224|Proteobacteria 1224|Proteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_69131_1 555779.Dthio_PD3358 0.00085 44.7 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MBG2@213115|Desulfovibrionales 28221|Deltaproteobacteria T Universal stress protein usp-2 - - ko:K06149 - - - - ko00000 - - - Usp k59_69131_2 177437.HRM2_13670 1.81e-09 60.1 COG4191@1|root,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2MI1D@213118|Desulfobacterales 28221|Deltaproteobacteria T GHKL domain - - - - - - - - - - - - HATPase_c,PAS_9 k59_3481_1 880072.Desac_0486 2.51e-119 366.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MQ5F@213462|Syntrophobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_100887_1 338966.Ppro_3199 3.47e-108 328.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,43S3B@69541|Desulfuromonadales 28221|Deltaproteobacteria O CAAX prenyl protease N-terminal, five membrane helices - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_121363_2 1210884.HG799466_gene13029 1.85e-11 65.1 28H70@1|root,2Z7JB@2|Bacteria,2J1WR@203682|Planctomycetes 203682|Planctomycetes S Multiubiquitin - - - - - - - - - - - - Multi_ubiq k59_165863_1 693661.Arcve_0923 1.01e-83 256.0 COG0725@1|root,arCOG00219@2157|Archaea,2XWT8@28890|Euryarchaeota 28890|Euryarchaeota P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_16503_1 84531.JMTZ01000003_gene2364 6.46e-35 140.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1X3AB@135614|Xanthomonadales 135614|Xanthomonadales Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_62726_1 452637.Oter_3802 9.13e-156 469.0 COG0841@1|root,COG0841@2|Bacteria,46SDW@74201|Verrucomicrobia,3K7E7@414999|Opitutae 414999|Opitutae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_127994_1 96561.Dole_0966 3.47e-99 303.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_62971_1 1121459.AQXE01000018_gene2066 8.11e-44 155.0 COG0845@1|root,COG0845@2|Bacteria,1RBJ2@1224|Proteobacteria,42SNM@68525|delta/epsilon subdivisions,2WPKM@28221|Deltaproteobacteria,2M8DM@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_62971_2 1049564.TevJSym_aa02020 4.36e-110 347.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J7FH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_159993_1 572547.Amico_1331 3.06e-56 198.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 k59_16690_2 1301098.PKB_0230 4.12e-09 56.2 COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,1SG1K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Lipid A Biosynthesis N-terminal domain - - - - - - - - - - - - LAB_N k59_134069_1 1049564.TevJSym_au00270 0.0 1288.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1J4ZW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_88494_1 502025.Hoch_1020 6.14e-27 111.0 COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria,2Z20S@29|Myxococcales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_88494_2 426114.THI_3654 1.11e-17 82.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria 28216|Betaproteobacteria EG of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_140069_1 1198232.CYCME_0023 1.31e-142 409.0 COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,45ZU6@72273|Thiotrichales 72273|Thiotrichales H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - ThiI k59_192172_2 1155718.KB891898_gene1903 1.79e-29 117.0 COG0697@1|root,COG0697@2|Bacteria,2GP9G@201174|Actinobacteria 201174|Actinobacteria EG Permeases of the drug metabolite transporter DMT superfamily - - - - - - - - - - - - DUF1918,EamA k59_166057_1 1173024.KI912149_gene5927 5.29e-40 135.0 COG1917@1|root,COG1917@2|Bacteria,1GDR4@1117|Cyanobacteria,1JMIN@1189|Stigonemataceae 1117|Cyanobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_166057_3 1177179.A11A3_00700 1.17e-34 128.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1XJAX@135619|Oceanospirillales 135619|Oceanospirillales L Integrase catalytic - - - - - - - - - - - - HTH_38,rve k59_166057_5 1202962.KB907150_gene1933 1.45e-87 262.0 COG1247@1|root,COG1247@2|Bacteria,1R9WS@1224|Proteobacteria,1S20F@1236|Gammaproteobacteria 1236|Gammaproteobacteria M -acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_140071_1 1336233.JAEH01000001_gene724 4.84e-24 105.0 COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,2QETZ@267890|Shewanellaceae 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_128214_2 1124983.PFLCHA0_c30330 1.74e-54 189.0 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,1S1M0@1236|Gammaproteobacteria,1YNCV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria IQ synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_36941_1 335543.Sfum_2414 2.26e-80 250.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales 28221|Deltaproteobacteria Q COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_186292_1 1304875.JAFZ01000001_gene823 3.85e-71 227.0 COG0477@1|root,COG2814@2|Bacteria,3TACG@508458|Synergistetes 508458|Synergistetes EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_186292_2 237368.SCABRO_01640 1.32e-62 204.0 COG3608@1|root,COG3608@2|Bacteria 237368.SCABRO_01640|- G succinylglutamate desuccinylase aspartoacylase - - - - - - - - - - - - - k59_71529_1 1379698.RBG1_1C00001G1647 1.52e-55 186.0 COG0673@1|root,COG0673@2|Bacteria,2NNUQ@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA k59_181709_1 56780.SYN_00591 4.02e-84 254.0 COG1225@1|root,COG1225@2|Bacteria,1N9JS@1224|Proteobacteria,42R82@68525|delta/epsilon subdivisions,2WMVA@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - AhpC-TSA k59_181709_2 1265505.ATUG01000003_gene350 8.88e-29 109.0 COG1225@1|root,COG1225@2|Bacteria,1N3ZR@1224|Proteobacteria,42TQK@68525|delta/epsilon subdivisions,2WQSX@28221|Deltaproteobacteria,2MKQ0@213118|Desulfobacterales 28221|Deltaproteobacteria O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA,Redoxin k59_155780_1 269799.Gmet_0465 3.87e-08 53.1 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,43UNE@69541|Desulfuromonadales 28221|Deltaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_155780_2 1121405.dsmv_2571 3.1e-22 94.4 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales 28221|Deltaproteobacteria E aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_6693_1 118163.Ple7327_0411 8.95e-53 178.0 COG1180@1|root,COG1180@2|Bacteria,1G268@1117|Cyanobacteria,3VJEX@52604|Pleurocapsales 1117|Cyanobacteria C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_32619_1 105559.Nwat_0606 8.08e-34 129.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_32619_2 1049564.TevJSym_bi00320 1.58e-09 60.8 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1J4R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_201173_1 697282.Mettu_4130 5.32e-26 107.0 COG3259@1|root,COG3259@2|Bacteria,1RFVW@1224|Proteobacteria,1T354@1236|Gammaproteobacteria,1XG2J@135618|Methylococcales 135618|Methylococcales C Nickel-dependent hydrogenase - - - - - - - - - - - - - k59_201173_2 1122201.AUAZ01000001_gene2319 8.67e-49 158.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,46BHX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Hydrogenase/urease nickel incorporation, metallochaperone, hypA hypA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_45577_1 933262.AXAM01000027_gene2093 8.71e-26 97.8 2DSF3@1|root,33FWE@2|Bacteria,1NJN0@1224|Proteobacteria,42WZP@68525|delta/epsilon subdivisions,2WSXA@28221|Deltaproteobacteria,2MM8I@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_45577_2 243275.TDE_0210 7.28e-21 88.2 COG2109@1|root,COG2109@2|Bacteria,2J8WE@203691|Spirochaetes 203691|Spirochaetes H ATP corrinoid adenosyltransferase BtuR CobO CobP - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_168719_1 1396858.Q666_14530 3.42e-51 167.0 2DC7W@1|root,2ZD7C@2|Bacteria,1QU8S@1224|Proteobacteria,1S6MA@1236|Gammaproteobacteria,46BPC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_19983_1 1049564.TevJSym_aa01680 1.21e-123 357.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1J4M2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_188513_1 580340.Tlie_1382 1.35e-60 206.0 COG0191@1|root,COG0191@2|Bacteria,3TAAI@508458|Synergistetes 508458|Synergistetes G PFAM ketose-bisphosphate aldolase class-II - - - - - - - - - - - - F_bP_aldolase k59_149664_2 322710.Avin_15590 2.88e-26 115.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1T1JX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase cpxA - 2.7.13.3 ko:K07640 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_175504_1 329726.AM1_0095 7.73e-07 56.2 COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria 1117|Cyanobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_97714_1 1324957.K933_16552 3e-07 58.9 COG3291@1|root,COG3979@1|root,arCOG02499@1|root,arCOG07560@1|root,arCOG02499@2157|Archaea,arCOG02508@2157|Archaea,arCOG07560@2157|Archaea,arCOG07581@2157|Archaea,2Y80Y@28890|Euryarchaeota,24124@183963|Halobacteria 183963|Halobacteria G COG3291 FOG PKD repeat - - - - - - - - - - - - PKD k59_188519_1 864069.MicloDRAFT_00070050 6.99e-65 211.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2UHF6@28211|Alphaproteobacteria,1JYH1@119045|Methylobacteriaceae 28211|Alphaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM k59_104202_1 525897.Dbac_0806 6.73e-93 277.0 COG0765@1|root,COG0765@2|Bacteria,1QSE9@1224|Proteobacteria,42PC3@68525|delta/epsilon subdivisions,2WIMY@28221|Deltaproteobacteria,2MAQF@213115|Desulfovibrionales 28221|Deltaproteobacteria P amino acid ABC transporter - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_58916_1 1049564.TevJSym_af00410 5.66e-145 424.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1J4DX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_136661_1 644282.Deba_1164 5.61e-37 143.0 COG3523@1|root,COG3523@2|Bacteria,1NRHK@1224|Proteobacteria,42Z87@68525|delta/epsilon subdivisions,2WTYM@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_201548_1 857087.Metme_3359 1.98e-177 530.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1XG1J@135618|Methylococcales 135618|Methylococcales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_19989_2 1049564.TevJSym_bh00110 2.25e-138 400.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1J577@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_97721_1 913325.N799_00155 6.57e-05 48.5 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1X5IM@135614|Xanthomonadales 135614|Xanthomonadales NU type IV pilus biogenesis stability protein PilW pilF - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_10,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8 k59_97721_2 909663.KI867150_gene1748 9.98e-16 75.1 COG2456@1|root,COG2456@2|Bacteria,1NF5Z@1224|Proteobacteria,42VNI@68525|delta/epsilon subdivisions,2WS2M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterized conserved protein (DUF2304) - - - ko:K09153 - - - - ko00000 - - - DUF2304 k59_143098_1 1121405.dsmv_3251 1.24e-100 316.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_123693_1 1500894.JQNN01000001_gene206 1.14e-73 230.0 COG1028@1|root,COG1028@2|Bacteria,1RI2A@1224|Proteobacteria,2W3DI@28216|Betaproteobacteria 28216|Betaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_188528_1 1049564.TevJSym_ac02060 3.18e-78 253.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1J4NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_149672_1 243233.MCA2814 7.9e-49 176.0 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1XEPS@135618|Methylococcales 135618|Methylococcales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_149672_2 1122951.ATUE01000006_gene1391 1.6e-20 87.8 COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,1S7E9@1236|Gammaproteobacteria,3NJ2F@468|Moraxellaceae 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K18301 - M00642 - - ko00000,ko00002,ko01504,ko03000 - - - TetR_C_7,TetR_N k59_188532_1 338963.Pcar_3003 2.78e-61 212.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_26512_1 398767.Glov_1761 9.88e-72 229.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria 28221|Deltaproteobacteria J PFAM tRNA synthetase, class II (G, H, P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_32928_1 1158294.JOMI01000001_gene1530 7.76e-19 90.5 COG1453@1|root,COG1453@2|Bacteria,4NJU2@976|Bacteroidetes,2G2UD@200643|Bacteroidia 976|Bacteroidetes S Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k59_13466_1 1173264.KI913949_gene1265 9.29e-32 126.0 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_26514_1 1500890.JQNL01000001_gene1089 5.71e-11 68.2 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria,1X4RA@135614|Xanthomonadales 135614|Xanthomonadales S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_32929_1 861299.J421_1525 1.53e-23 95.1 COG1047@1|root,COG1047@2|Bacteria 2|Bacteria O modulation by symbiont of host adenylate cyclase-mediated signal transduction slyD - 5.2.1.8 ko:K01802,ko:K03774,ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_136667_1 1120963.KB894504_gene1891 3.8e-05 44.7 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,2PZNU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S involved in the control of DNA gyrase tldD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_136667_2 1049564.TevJSym_ak00720 9.35e-230 643.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1J7BF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative modulator of DNA gyrase pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_136667_3 572477.Alvin_0812 2.62e-142 412.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales 135613|Chromatiales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_20003_1 1121403.AUCV01000002_gene499 2.86e-37 143.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MIQB@213118|Desulfobacterales 28221|Deltaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_20003_2 889378.Spiaf_2668 1.24e-18 80.1 COG1925@1|root,COG1925@2|Bacteria,2J8AV@203691|Spirochaetes 203691|Spirochaetes G phosphocarrier protein HPr - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_104224_1 472759.Nhal_2012 1.35e-149 451.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_149673_1 631362.Thi970DRAFT_00075 1.53e-41 137.0 COG1598@1|root,COG1598@2|Bacteria,1NC35@1224|Proteobacteria,1SRZV@1236|Gammaproteobacteria,1X1FP@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - - k59_149673_2 1469607.KK073768_gene2276 2.05e-10 58.5 28QA0@1|root,2ZCSN@2|Bacteria,1GFXM@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_149673_3 1116472.MGMO_74c00130 4.28e-44 148.0 COG1848@1|root,COG1848@2|Bacteria 2|Bacteria G Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_20005_1 1049564.TevJSym_af00750 1.85e-66 219.0 COG1538@1|root,COG1538@2|Bacteria,1RDNB@1224|Proteobacteria,1S535@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_136671_1 1434929.X946_5208 7.05e-19 82.4 COG1846@1|root,COG1846@2|Bacteria,1N150@1224|Proteobacteria,2VVF3@28216|Betaproteobacteria,1K6JN@119060|Burkholderiaceae 28216|Betaproteobacteria K Regulatory protein MarR hcaR - - - - - - - - - - - MarR,MarR_2 k59_136671_2 443598.AUFA01000081_gene4784 1.76e-105 314.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TUMG@28211|Alphaproteobacteria,3JSTH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.90 ko:K00055 ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220 M00537,M00538 R01763,R02611,R04304,R05282,R05347,R05348 RC00087,RC00116 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_162660_1 748280.NH8B_0126 1.69e-48 166.0 COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,2VQ1F@28216|Betaproteobacteria 28216|Betaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_17 k59_32935_2 1957.JODX01000001_gene5194 7.05e-07 55.1 COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria 201174|Actinobacteria G Phosphoglycerate mutase - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_143118_1 555779.Dthio_PD3188 2.26e-87 278.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales 28221|Deltaproteobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338 k59_149677_2 519989.ECTPHS_06812 6.18e-54 181.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_7090_1 335543.Sfum_1661 6.56e-55 194.0 COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MQW0@213462|Syntrophobacterales 28221|Deltaproteobacteria S Peptidase M16C associated PREP - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_26523_1 237368.SCABRO_02093 4.47e-167 481.0 COG0415@1|root,COG0415@2|Bacteria,2IXWI@203682|Planctomycetes 203682|Planctomycetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase k59_162666_1 1121405.dsmv_2750 9.42e-70 226.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Starch synthase catalytic - - 2.4.1.21,3.2.1.1 ko:K00703,ko:K01176 ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973 M00565 R02108,R02112,R02421,R11262 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GH13,GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_194926_1 247634.GPB2148_3863 0.0 1003.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria,1J9IN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E 2Fe-2S iron-sulfur cluster binding domain soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_194926_2 1192124.LIG30_4368 2.24e-33 126.0 COG4583@1|root,COG4583@2|Bacteria,1R7AA@1224|Proteobacteria,2VP9M@28216|Betaproteobacteria,1KHKY@119060|Burkholderiaceae 28216|Betaproteobacteria E Sarcosine oxidase, gamma subunit soxG - 1.5.3.1 ko:K00305 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxG k59_194926_3 748247.AZKH_p0204 1.5e-143 414.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,2KVJ6@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - Formyl_trans_N k59_194926_4 748247.AZKH_p0169 2.19e-126 364.0 COG5012@1|root,COG5012@2|Bacteria 2|Bacteria T cobalamin binding mtbC - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2 k59_194926_5 748247.AZKH_p0168 5.15e-81 247.0 28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_194926_6 1313172.YM304_35700 1.63e-11 67.0 28I8Y@1|root,2Z8BR@2|Bacteria,2IJ1B@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_194926_7 748247.AZKH_p0166 7.28e-74 225.0 COG0685@1|root,COG0685@2|Bacteria,1RDXU@1224|Proteobacteria 1224|Proteobacteria E Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_194926_8 748247.AZKH_p0165 1.42e-180 509.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria 1224|Proteobacteria E Methylenetetrahydrofolate reductase metF - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_194926_9 748247.AZKH_p0164 5.07e-157 447.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria 1224|Proteobacteria H Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13,2.1.1.258 ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00377 R00946,R02289,R09365,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_78494_1 1121405.dsmv_1096 2.46e-47 172.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MMXV@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_20007_1 1026882.MAMP_01655 8.62e-42 142.0 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,4614E@72273|Thiotrichales 72273|Thiotrichales N flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_20007_3 338969.Rfer_0255 1.15e-20 90.5 COG3303@1|root,COG3303@2|Bacteria,1NX4E@1224|Proteobacteria 1224|Proteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_20007_4 1049564.TevJSym_aa01640 2.84e-116 340.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1J5XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S transport system, permease component ypjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cytochrom_C_asm k59_26528_1 335543.Sfum_3071 1.91e-102 305.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,2MQBV@213462|Syntrophobacterales 28221|Deltaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_58937_1 335543.Sfum_2658 9.59e-65 215.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,PAS,PAS_3,PAS_9,Response_reg k59_104234_1 933262.AXAM01000013_gene1280 4.44e-85 261.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2MJ20@213118|Desulfobacterales 28221|Deltaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_52404_1 1049564.TevJSym_ah00480 1.03e-43 153.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1J5T0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rlmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070041,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_52404_2 1134474.O59_003487 5.1e-19 84.0 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1FHCT@10|Cellvibrio 1236|Gammaproteobacteria S CYTH - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_130283_2 1049564.TevJSym_aw00060 1.4e-40 147.0 28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - dsrS - - - - - - - - - - - - k59_78499_1 1121396.KB893101_gene485 2.2e-36 131.0 COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WNJJ@28221|Deltaproteobacteria,2MPVD@213118|Desulfobacterales 28221|Deltaproteobacteria S Colicin V production protein - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_182089_1 1049564.TevJSym_ak00550 2.88e-23 92.0 COG1918@1|root,COG1918@2|Bacteria,1NBG2@1224|Proteobacteria,1SE39@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_182089_2 1049564.TevJSym_ak00560 1.23e-39 146.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_110756_1 1122135.KB893134_gene3280 5.09e-63 199.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_58945_1 399739.Pmen_2332 3.73e-71 238.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,1YIPB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Gp5 C-terminal repeat (3 copies) - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Gp5_C,Phage_GPD k59_182091_1 795666.MW7_0980 5.89e-40 139.0 COG5449@1|root,COG5449@2|Bacteria,1PWCX@1224|Proteobacteria,2VP21@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_182091_2 1265502.KB905983_gene554 1.1e-39 132.0 2CJX7@1|root,32W32@2|Bacteria,1N82M@1224|Proteobacteria,2VY34@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_149687_1 1049564.TevJSym_an00130 3.37e-112 329.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1J5RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_149687_2 1049564.TevJSym_ab00620 4.88e-200 563.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1J5BC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II IV02_28760 - - - - - - - - - - - Aminotran_1_2 k59_204043_1 1209072.ALBT01000128_gene2 3.36e-07 56.2 COG3119@1|root,COG3119@2|Bacteria,1N6NX@1224|Proteobacteria,1RPWH@1236|Gammaproteobacteria,1FG47@10|Cellvibrio 1236|Gammaproteobacteria P Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_74064_1 279238.Saro_2809 1.1e-95 298.0 COG3670@1|root,COG3670@2|Bacteria 2|Bacteria Q oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_158752_1 439235.Dalk_1816 4.84e-49 171.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria,2MJ2S@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_152419_2 314285.KT71_13909 1.51e-28 109.0 28NPY@1|root,2ZBPP@2|Bacteria,1R85U@1224|Proteobacteria,1S4SA@1236|Gammaproteobacteria,1JB6U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Conjugal transfer protein - - - - - - - - - - - - - k59_68374_1 335543.Sfum_1831 1.56e-69 227.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQWY@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM ribonuclease, Rne Rng family rne - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_68374_2 555779.Dthio_PD1800 1.39e-44 157.0 COG3581@1|root,COG3581@2|Bacteria,1N1N8@1224|Proteobacteria,42UB7@68525|delta/epsilon subdivisions,2WQ9V@28221|Deltaproteobacteria,2MHJM@213115|Desulfovibrionales 28221|Deltaproteobacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k59_48826_1 1049564.TevJSym_aw00130 2.59e-144 419.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_159027_1 1049564.TevJSym_at00180 1.23e-133 384.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1J5J9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the dihydroorotate dehydrogenase family pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,NAD_binding_1 k59_10006_1 857087.Metme_1124 1.16e-101 334.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_10006_3 319224.Sputcn32_0178 1.56e-93 279.0 COG0582@1|root,COG0582@2|Bacteria,1QRWN@1224|Proteobacteria,1SVK3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_10006_4 391625.PPSIR1_13960 7.89e-31 132.0 COG0515@1|root,COG0515@2|Bacteria,1Q31J@1224|Proteobacteria,433X4@68525|delta/epsilon subdivisions,2X375@28221|Deltaproteobacteria,2YXM5@29|Myxococcales 28221|Deltaproteobacteria H Protein kinase domain - - - - - - - - - - - - Pkinase k59_74300_1 1121405.dsmv_0566 5.8e-45 158.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2MIAF@213118|Desulfobacterales 28221|Deltaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_87635_1 1049564.TevJSym_ab01210 3.74e-214 618.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_81408_1 1121405.dsmv_1700 2.75e-28 111.0 COG2203@1|root,COG2203@2|Bacteria,1R8AK@1224|Proteobacteria,42MTP@68525|delta/epsilon subdivisions,2WIST@28221|Deltaproteobacteria,2MIJP@213118|Desulfobacterales 28221|Deltaproteobacteria T GAF domain - - - - - - - - - - - - GAF_2 k59_81408_2 1121405.dsmv_1701 6.82e-59 185.0 COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,42SWX@68525|delta/epsilon subdivisions,2WPJ0@28221|Deltaproteobacteria,2MK5C@213118|Desulfobacterales 28221|Deltaproteobacteria I MaoC like domain maoC - 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_146143_1 1219065.VPR01S_05_00950 5.09e-96 285.0 COG4977@1|root,COG4977@2|Bacteria,1QUTI@1224|Proteobacteria,1T352@1236|Gammaproteobacteria,1XTTX@135623|Vibrionales 135623|Vibrionales K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_165284_1 674977.VMC_07080 6.72e-21 89.4 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1XV5N@135623|Vibrionales 135623|Vibrionales S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_36019_1 1049564.TevJSym_aa01300 1.53e-88 273.0 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1J5VY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG3951 Rod binding protein flgJ GO:0003674,GO:0005198 - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_36019_2 1049564.TevJSym_aa01310 2.97e-200 585.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,1RMEA@1236|Gammaproteobacteria,1J4DG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_127275_1 933262.AXAM01000052_gene2006 6.04e-87 258.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_127275_2 1121405.dsmv_3572 1.42e-15 69.7 COG1841@1|root,COG1841@2|Bacteria,1PU2T@1224|Proteobacteria,42WNP@68525|delta/epsilon subdivisions,2WRZZ@28221|Deltaproteobacteria,2MM1B@213118|Desulfobacterales 28221|Deltaproteobacteria J Ribosomal protein L30p/L7e rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_94880_1 1122236.KB905141_gene896 7.1e-21 96.7 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VMQS@28216|Betaproteobacteria,2KKDD@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM extracellular solute-binding protein family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_2974_1 324925.Ppha_1666 7.06e-160 473.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_107179_1 1123400.KB904746_gene1169 4.84e-118 344.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,4604G@72273|Thiotrichales 72273|Thiotrichales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_146146_1 502025.Hoch_5432 1.1e-50 167.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2YVG1@29|Myxococcales 28221|Deltaproteobacteria L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_146146_2 1089553.Tph_c04060 8.15e-16 78.2 COG2159@1|root,COG2159@2|Bacteria,1UE47@1239|Firmicutes,24D71@186801|Clostridia,42F3R@68295|Thermoanaerobacterales 186801|Clostridia S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_62021_1 717231.Flexsi_1531 5.33e-46 156.0 COG0410@1|root,COG0410@2|Bacteria 2|Bacteria E branched-chain amino acid transmembrane transporter activity - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_62021_2 999541.bgla_1g00780 5.4e-19 87.4 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,1K2GT@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_43030_1 1049564.TevJSym_aj00060 6.51e-41 154.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,1J98N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_133325_1 287.DR97_1657 5.29e-59 190.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1YEU5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Maf-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_133325_2 1049564.TevJSym_ak00660 1.08e-07 50.8 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1J6C3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_10016_1 768706.Desor_2212 7.81e-32 123.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,260BK@186807|Peptococcaceae 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_74304_1 1049564.TevJSym_aj00730 3.29e-122 374.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1J4N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_9,Response_reg k59_48828_2 2340.JV46_06340 1.92e-18 83.6 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1J4H8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_204289_1 867903.ThesuDRAFT_01667 3.92e-43 154.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,3WCDX@538999|Clostridiales incertae sedis 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_68396_1 1121405.dsmv_2041 1.33e-62 204.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MIT3@213118|Desulfobacterales 28221|Deltaproteobacteria O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - iAF987.Gmet_0117 HypD k59_113548_4 1396418.BATQ01000179_gene3142 1.52e-20 107.0 COG1345@1|root,COG1404@1|root,COG1345@2|Bacteria,COG1404@2|Bacteria,46UMW@74201|Verrucomicrobia,2IUFG@203494|Verrucomicrobiae 203494|Verrucomicrobiae O Subtilase family - - - - - - - - - - - - PQQ_2,Peptidase_S8 k59_81419_1 690850.Desaf_3501 4.91e-07 57.0 COG3210@1|root,COG4412@1|root,COG3210@2|Bacteria,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2MEAM@213115|Desulfovibrionales 28221|Deltaproteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PA,Peptidase_M36,REJ k59_2980_1 1173263.Syn7502_00957 2.84e-22 96.3 COG0745@1|root,COG0745@2|Bacteria,1FZYI@1117|Cyanobacteria,1GZU7@1129|Synechococcus 1117|Cyanobacteria T cheY-homologous receiver domain - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - DUF4388,Response_reg k59_2980_2 224308.BSU29110 6.98e-28 109.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,1ZBGS@1386|Bacillus 91061|Bacilli T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_87642_2 90813.JQMT01000001_gene1490 2.06e-58 187.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,460RV@72273|Thiotrichales 72273|Thiotrichales T Low molecular weight phosphotyrosine protein phosphatase yfkJ - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_165295_1 545276.KB898731_gene2271 1.85e-81 261.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_191464_1 1499967.BAYZ01000009_gene5335 7.85e-79 249.0 COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria 2|Bacteria S Belongs to the RtcB family rtcB GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_74309_1 880072.Desac_0499 9.67e-111 331.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_204292_1 1211813.CAPH01000017_gene825 6.8e-51 178.0 COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,2FM28@200643|Bacteroidia,22UYZ@171550|Rikenellaceae 976|Bacteroidetes I Acyl-CoA dehydrogenase, C-terminal domain acd - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_dehyd_C k59_54974_1 177437.HRM2_42590 3.12e-46 154.0 COG4087@1|root,COG4087@2|Bacteria,1N05K@1224|Proteobacteria,42U05@68525|delta/epsilon subdivisions,2WQDW@28221|Deltaproteobacteria,2MKK8@213118|Desulfobacterales 28221|Deltaproteobacteria S COGs COG4087 Soluble P-type ATPase - - - - - - - - - - - - Hydrolase,Hydrolase_3 k59_48835_1 909663.KI867150_gene2885 3.08e-90 292.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQUP@213462|Syntrophobacterales 28221|Deltaproteobacteria U Hydrophobe amphiphile Efflux-1 (HAE1) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_120585_1 667014.Thein_1357 9.62e-13 73.6 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GGV4@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria I CoA enzyme activase uncharacterised domain (DUF2229) - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_113550_1 713586.KB900537_gene3099 5.83e-27 119.0 2DCM2@1|root,32TZV@2|Bacteria,1NAGE@1224|Proteobacteria,1SMRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_100332_1 880072.Desac_1117 2.06e-69 221.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,42P13@68525|delta/epsilon subdivisions,2WMM6@28221|Deltaproteobacteria,2MR0Q@213462|Syntrophobacterales 28221|Deltaproteobacteria C M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 k59_197467_1 485913.Krac_6492 3.9e-12 76.6 COG3316@1|root,COG3316@2|Bacteria 2|Bacteria - - - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Transposase_mut,zf-IS66 k59_139244_1 1049564.TevJSym_au00620 8.49e-73 225.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1J4VY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0568 DNA-directed RNA polymerase, sigma subunit rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_139244_2 519989.ECTPHS_04019 2.05e-48 167.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_107192_1 335543.Sfum_1666 1.29e-46 159.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2MQGR@213462|Syntrophobacterales 28221|Deltaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_107192_2 243231.GSU1242 4.26e-08 53.9 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,43TQ7@69541|Desulfuromonadales 28221|Deltaproteobacteria H PFAM aminotransferase, class I and II aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_172048_1 1177928.TH2_01505 3.77e-42 143.0 COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2U98M@28211|Alphaproteobacteria,2JT2N@204441|Rhodospirillales 204441|Rhodospirillales K Transcriptional regulators - - - - - - - - - - - - MerR_1 k59_172147_2 1049564.TevJSym_as00660 1.41e-161 493.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_81643_1 1123053.AUDG01000017_gene3299 1e-66 227.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1WWJF@135613|Chromatiales 135613|Chromatiales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_81643_3 1280692.AUJL01000018_gene964 8.22e-13 71.6 COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,36E9Q@31979|Clostridiaceae 186801|Clostridia F Deoxyguanosinetriphosphate triphosphohydrolase - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_127538_1 1265505.ATUG01000001_gene2862 4.01e-15 70.9 COG1433@1|root,COG1433@2|Bacteria,1N799@1224|Proteobacteria,42V7X@68525|delta/epsilon subdivisions,2WRG1@28221|Deltaproteobacteria,2MKXV@213118|Desulfobacterales 28221|Deltaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_127538_2 335543.Sfum_0651 8.44e-43 156.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MQZE@213462|Syntrophobacterales 28221|Deltaproteobacteria T Cache domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_120833_1 439235.Dalk_2275 3.87e-25 101.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,2MJ8Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Hydrogenase (NiFe) small subunit HydA hydA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 ko:K00534,ko:K05927,ko:K06282,ko:K18008 ko00633,ko01120,map00633,map01120 - R00019,R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_23242_1 1122194.AUHU01000006_gene526 9.91e-61 194.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,4641M@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF1989) IV02_09290 - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_133497_1 96561.Dole_0844 5.62e-33 122.0 COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales 28221|Deltaproteobacteria L SMART Chromosomal replication initiator DnaA domain - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_178879_1 765913.ThidrDRAFT_0525 8.68e-154 451.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X037@135613|Chromatiales 135613|Chromatiales G Pyrrolo-quinoline quinone - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_135794_2 1049564.TevJSym_ak00740 1.45e-119 362.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1JC0Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_64598_2 1116472.MGMO_6c00210 5.41e-15 82.8 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1XF4P@135618|Methylococcales 135618|Methylococcales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_64598_3 1049564.TevJSym_am00380 4.69e-48 165.0 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria,1J75C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Type IV pilus assembly protein PilX C-term pilX - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_199900_2 1121439.dsat_0639 3.41e-201 585.0 COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,2MEF8@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_18517_2 985665.HPL003_25985 8.74e-24 100.0 COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,4HAKQ@91061|Bacilli,26T0E@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_193777_4 1049564.TevJSym_be00350 3.27e-127 365.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1J59F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_83780_1 324925.Ppha_2833 1.81e-100 310.0 COG0318@1|root,COG0318@2|Bacteria,1FDAB@1090|Chlorobi 1090|Chlorobi IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_25668_2 1121935.AQXX01000142_gene2325 1.08e-23 95.5 28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria,1S0GG@1236|Gammaproteobacteria,1XNAN@135619|Oceanospirillales 135619|Oceanospirillales S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_18524_1 324602.Caur_0701 3.28e-31 119.0 COG0274@1|root,COG0274@2|Bacteria,2G7HC@200795|Chloroflexi,375WJ@32061|Chloroflexia 32061|Chloroflexia H Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_25669_1 1229780.BN381_250012 3.14e-47 168.0 COG3464@1|root,COG3464@2|Bacteria,2I56J@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - - k59_102780_1 1049564.TevJSym_aa02360 1.88e-228 637.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J53P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_83789_1 1385935.N836_09965 1.2e-54 192.0 COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria,1HDU6@1150|Oscillatoriales 1117|Cyanobacteria K transcriptional regulator - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_25672_1 96561.Dole_0153 2.8e-67 223.0 28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative ATP-binding cassette - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 k59_25672_2 1304885.AUEY01000032_gene2007 1.29e-17 82.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_180942_3 2340.JV46_23930 1.13e-22 93.2 COG0695@1|root,COG0695@2|Bacteria,1PPNJ@1224|Proteobacteria,1TC2E@1236|Gammaproteobacteria,1J75T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Glutaredoxin - - - - - - - - - - - - Glutaredoxin k59_180942_4 765910.MARPU_12630 2.58e-141 423.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_5236_1 933262.AXAM01000034_gene1556 6.6e-42 154.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MHPA@213118|Desulfobacterales 28221|Deltaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_51474_3 768671.ThimaDRAFT_0769 1.1e-49 168.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1WXHE@135613|Chromatiales 135613|Chromatiales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_51474_4 1049564.TevJSym_ah00180 0.0 903.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1J4IX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_12866_1 177437.HRM2_43560 2.4e-69 223.0 COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,1N4K5@1224|Proteobacteria,42T2F@68525|delta/epsilon subdivisions,2WPGM@28221|Deltaproteobacteria,2MKRM@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE k59_206760_1 247633.GP2143_05565 2.04e-74 248.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the GcvT family soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_206760_2 1097668.BYI23_B012790 9.01e-43 141.0 COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2VU5D@28216|Betaproteobacteria,1K8MN@119060|Burkholderiaceae 28216|Betaproteobacteria E Sarcosine oxidase delta subunit soxD - 1.5.3.1 ko:K00304 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxD k59_206760_3 1304275.C41B8_00225 6.47e-258 712.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,1RRHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Sarcosine oxidase, subunit beta soxB - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_206760_4 42256.RradSPS_2313 9.06e-54 173.0 COG3791@1|root,COG3791@2|Bacteria 2|Bacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_206760_5 243365.CV_2874 1.97e-245 684.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2VH8K@28216|Betaproteobacteria,2KQ6E@206351|Neisseriales 206351|Neisseriales E L-serine dehydratase - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_206760_6 1348657.M622_01105 5.48e-237 659.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,2KUDA@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - - - - - - - - - - - SHMT k59_206760_7 391937.NA2_06313 2.12e-252 707.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,2TQR4@28211|Alphaproteobacteria,43J24@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Belongs to the BCCT transporter (TC 2.A.15) family betS - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_206760_8 1033802.SSPSH_003291 8.47e-41 140.0 COG0589@1|root,COG0589@2|Bacteria,1N7EK@1224|Proteobacteria,1SCRX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_206760_9 1266914.ATUK01000011_gene2302 1.62e-197 558.0 COG3746@1|root,COG3746@2|Bacteria,1Q3GY@1224|Proteobacteria,1RNGT@1236|Gammaproteobacteria,1WWCU@135613|Chromatiales 135613|Chromatiales P phosphate-selective porin O and P - - - - - - - - - - - - - k59_25831_2 661367.LLO_0183 1.3e-82 298.0 COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,1RB38@1224|Proteobacteria,1RXFB@1236|Gammaproteobacteria,1JCPP@118969|Legionellales 118969|Legionellales G Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase k59_25831_3 398527.Bphyt_4752 5.64e-11 74.3 2EI9K@1|root,33C0Y@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_25831_4 555088.DealDRAFT_1304 3.93e-21 108.0 COG2909@1|root,COG3947@1|root,COG2909@2|Bacteria,COG3947@2|Bacteria,1UIMV@1239|Firmicutes,25GAH@186801|Clostridia 186801|Clostridia K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_22,BTAD k59_77086_1 1049564.TevJSym_as00330 4.24e-08 53.1 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1J4QV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S stress-induced protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_174241_1 573370.DMR_27610 5.59e-33 124.0 2F9C1@1|root,341NY@2|Bacteria,1NXYC@1224|Proteobacteria,430UA@68525|delta/epsilon subdivisions,2WW49@28221|Deltaproteobacteria,2M8XW@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_12869_1 740709.A10D4_04515 1.77e-55 187.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,2QF80@267893|Idiomarinaceae 1236|Gammaproteobacteria I Belongs to the CDS family cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_1596,iSDY_1059.SDY_0191 CTP_transf_1 k59_12869_3 2340.JV46_15040 7.96e-34 121.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1J5ZJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_181159_2 908340.HMPREF9406_0139 6.07e-26 108.0 2DBKS@1|root,2Z9UX@2|Bacteria,1UYSQ@1239|Firmicutes,24QEK@186801|Clostridia,36TWR@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_84056_1 439235.Dalk_3804 7.18e-99 293.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NI5@68525|delta/epsilon subdivisions,2WIN8@28221|Deltaproteobacteria,2MPXX@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_18807_1 269797.Mbar_A0429 3.35e-09 58.5 COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia 224756|Methanomicrobia C Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing cdhE - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD,FeS k59_18807_2 335543.Sfum_1719 5.26e-16 80.1 2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MS8T@213462|Syntrophobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786 k59_148814_1 1232437.KL662077_gene1941 1.28e-224 631.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,43BQX@68525|delta/epsilon subdivisions,2X71W@28221|Deltaproteobacteria,2MIFV@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_194091_1 1163617.SCD_n02668 3.42e-48 164.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Phosphoribosyltransferase comF - - - - - - - - - - - Pribosyltran k59_206769_1 1121405.dsmv_2179 3.57e-122 357.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2MHQM@213118|Desulfobacterales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_168026_1 1121430.JMLG01000016_gene372 2.78e-49 171.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation - - 4.2.2.20,4.2.2.21 ko:K02026,ko:K03529,ko:K08961 - M00207 - - ko00000,ko00002,ko01000,ko02000,ko03036 3.A.1.1 - - BPD_transp_1,Big_4,FIVAR,Laminin_G_3,Lyase_8,Lyase_8_C,Lyase_N,Lyase_catalyt,MS_channel,SMC_N k59_181163_1 335543.Sfum_0390 2.09e-82 265.0 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cluster binding protein - - - - - - - - - - - - CCG,Fer4_7,Fer4_8,LUD_dom k59_155137_1 555779.Dthio_PD3510 8.46e-51 169.0 2EQ2X@1|root,33HPA@2|Bacteria,1NPZI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_136067_2 1216966.BAUC01000012_gene288 2.03e-24 103.0 COG1309@1|root,COG1309@2|Bacteria,1N659@1224|Proteobacteria,1RPXN@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator acrR GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03577 - M00647 - - ko00000,ko00002,ko03000 - - - TetR_C_2,TetR_N k59_103000_4 525897.Dbac_0608 1.16e-30 115.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria,2MG4D@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7,Band_7_C k59_194101_1 1047013.AQSP01000113_gene742 2.7e-13 72.8 28V7D@1|root,2ZHAI@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_32083_1 313612.L8106_14805 7.21e-52 176.0 COG0531@1|root,COG0531@2|Bacteria,1G9D1@1117|Cyanobacteria,1HDCZ@1150|Oscillatoriales 1117|Cyanobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_32083_2 521719.ATXQ01000001_gene501 9.9e-07 52.4 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1YE0G@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_12870_1 1238450.VIBNISOn1_1120001 1.07e-44 147.0 COG4551@1|root,COG4551@2|Bacteria,1N05F@1224|Proteobacteria,1TAXD@1236|Gammaproteobacteria,1XZ8T@135623|Vibrionales 135623|Vibrionales S Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - - - - - - - - - - - - k59_12870_3 470145.BACCOP_00110 7.93e-10 62.8 COG1670@1|root,COG1670@2|Bacteria,4NI5A@976|Bacteroidetes,2FNHY@200643|Bacteroidia,4AVIF@815|Bacteroidaceae 976|Bacteroidetes J guanosine monophosphate synthetase GuaA K01951 - - - - - - - - - - - - Acetyltransf_3 k59_12870_4 743299.Acife_0391 1.42e-63 202.0 2F082@1|root,33TBG@2|Bacteria,1N1X5@1224|Proteobacteria,1SKH9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_142173_3 1122915.AUGY01000052_gene451 1.74e-33 120.0 COG2076@1|root,COG2076@2|Bacteria,1VEUF@1239|Firmicutes,4HNA6@91061|Bacilli,2754V@186822|Paenibacillaceae 91061|Bacilli P Small Multidrug Resistance protein - - - ko:K03297 - - - - ko00000,ko02000 2.A.7.1 - - Multi_Drug_Res k59_142173_4 377629.TERTU_2895 2.18e-139 431.0 COG2730@1|root,COG5297@1|root,COG2730@2|Bacteria,COG5297@2|Bacteria,1N21U@1224|Proteobacteria,1RRB0@1236|Gammaproteobacteria,2PMTI@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Cellulase (glycosyl hydrolase family 5) - GO:0005575,GO:0005576 3.2.1.4,3.2.1.91 ko:K01179,ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R06200,R11307,R11308 RC00799 ko00000,ko00001,ko01000 - GH5,GH6,GH9 - CBM_10,CBM_5_12_2,Cellulase,TSP_3 k59_77102_1 644968.DFW101_2928 8.7e-15 74.3 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor livK-1 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iAF987.Gmet_1823 Peripla_BP_6 k59_77102_2 269799.Gmet_1822 3.41e-92 280.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,43U8V@69541|Desulfuromonadales 28221|Deltaproteobacteria P Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_136078_1 467661.RKLH11_3891 1.96e-116 349.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria 1224|Proteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_148827_1 1049564.TevJSym_bn00010 5.2e-50 179.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J59N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_32094_1 283942.IL2617 2.15e-76 244.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,2QEWZ@267893|Idiomarinaceae 1236|Gammaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4420,iYL1228.KPN_04135 Hexapep,Hexapep_2,NTP_transf_3 k59_181175_1 880072.Desac_0031 9.29e-61 197.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MRMI@213462|Syntrophobacterales 28221|Deltaproteobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_18824_1 439235.Dalk_0397 5.68e-64 213.0 COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - - - - - - - - - - - DisA_N,YbbR k59_18825_1 1163617.SCD_n02039 5.94e-87 281.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_148841_1 933262.AXAM01000021_gene450 2.62e-91 282.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,2MI6W@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_194132_2 1049564.TevJSym_as00540 8.44e-29 109.0 29QAQ@1|root,30B9W@2|Bacteria,1RGQ5@1224|Proteobacteria,1S5E4@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_200082_2 1234364.AMSF01000090_gene2458 2.63e-13 77.4 COG0226@1|root,COG1388@1|root,COG0226@2|Bacteria,COG1388@2|Bacteria,1NFY4@1224|Proteobacteria,1SX0T@1236|Gammaproteobacteria,1X4B3@135614|Xanthomonadales 135614|Xanthomonadales MP ABC-type phosphate transport system, periplasmic component - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - LysM,PBP_like_2 k59_151642_1 1120963.KB894521_gene5 7.64e-19 91.3 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,2Q12A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_14936_1 439235.Dalk_2276 5.56e-24 99.8 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hynA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 ko:K00437,ko:K00533,ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R00019,R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_145200_1 283699.D172_1212 1.07e-93 294.0 COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,2Q0GV@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E COG3227 Zinc metalloprotease (elastase) - - 3.4.24.25 ko:K08604 ko05110,ko05111,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002 - - - FTP,PPC,PepSY,Peptidase_M4,Peptidase_M4_C k59_47734_1 99598.Cal7507_3738 3.63e-77 260.0 COG3299@1|root,COG3299@2|Bacteria,1G6U3@1117|Cyanobacteria 1117|Cyanobacteria T protein, phage tail-like region - - - - - - - - - - - - Baseplate_J,Sortilin-Vps10 k59_47734_2 99598.Cal7507_3737 1.13e-99 317.0 COG3299@1|root,COG3299@2|Bacteria,1G3VV@1117|Cyanobacteria 1117|Cyanobacteria S protein, phage tail-like region - - - - - - - - - - - - Baseplate_J k59_119426_1 1162668.LFE_1341 5.52e-20 94.7 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DUF4277 k59_86689_1 1121405.dsmv_0564 1.69e-66 229.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_106033_1 1167006.UWK_01394 7.84e-70 236.0 COG2204@1|root,COG2461@1|root,COG3275@1|root,COG4191@1|root,COG2204@2|Bacteria,COG2461@2|Bacteria,COG3275@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_3 k59_80404_1 935863.AWZR01000007_gene259 1.01e-61 199.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm2 - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_80404_2 1121403.AUCV01000008_gene1627 5.47e-77 245.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42RAU@68525|delta/epsilon subdivisions,2WNNR@28221|Deltaproteobacteria,2MJSQ@213118|Desulfobacterales 28221|Deltaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_138413_1 1348908.KI518578_gene525 6.32e-37 135.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,4HAYM@91061|Bacilli,1ZBXG@1386|Bacillus 91061|Bacilli D COG1192 ATPases involved in chromosome partitioning soj GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_119591_3 1094715.CM001373_gene831 7.1e-30 116.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,1JDI2@118969|Legionellales 118969|Legionellales C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_112808_1 1049564.TevJSym_bd00140 4.24e-98 314.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_145382_1 1121921.KB898708_gene1562 8.98e-27 111.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,2PMT8@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_28517_1 1255043.TVNIR_1693 3.21e-58 189.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WW4I@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_196668_1 1168065.DOK_08449 4.27e-97 309.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1J4WH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0514 Superfamily II DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_196668_2 338963.Pcar_2841 5.2e-90 294.0 COG2365@1|root,COG3863@1|root,COG2365@2|Bacteria,COG3863@2|Bacteria,1RGE7@1224|Proteobacteria,42U1M@68525|delta/epsilon subdivisions,2WQE0@28221|Deltaproteobacteria,43W3C@69541|Desulfuromonadales 28221|Deltaproteobacteria T Dual specificity phosphatase, catalytic domain - - - - - - - - - - - - Y_phosphatase2 k59_164516_1 767817.Desgi_4476 2.63e-34 130.0 28J8Y@1|root,2Z943@2|Bacteria,1UKQN@1239|Firmicutes,25G19@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_60962_1 56780.SYN_02987 1.9e-61 202.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MRTS@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_132532_1 439235.Dalk_0661 1.73e-11 65.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver fgrM - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_138415_1 1121448.DGI_3258 1.43e-27 107.0 COG2199@1|root,COG2199@2|Bacteria,1QV9W@1224|Proteobacteria,43BP5@68525|delta/epsilon subdivisions,2X70F@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PilZ domain - - - - - - - - - - - - PilZ k59_60963_1 439235.Dalk_5090 1.53e-54 192.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_177769_3 1049564.TevJSym_an00650 2.11e-77 244.0 COG1073@1|root,COG1073@2|Bacteria,1RD2N@1224|Proteobacteria 1224|Proteobacteria S alpha beta - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,DUF1749 k59_28518_1 493475.GARC_2727 7.95e-136 397.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,1RP8C@1236|Gammaproteobacteria,463ZW@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0042710,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044010,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044764,GO:0045312,GO:0046204,GO:0046983,GO:0048037,GO:0050662,GO:0051704,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC k59_158103_1 1379281.AVAG01000025_gene1863 3.58e-70 220.0 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WJ9C@28221|Deltaproteobacteria,2M9NJ@213115|Desulfovibrionales 28221|Deltaproteobacteria ET extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_9145_1 1121405.dsmv_3084 1.61e-32 129.0 COG0477@1|root,COG2814@2|Bacteria,1R842@1224|Proteobacteria,42QBY@68525|delta/epsilon subdivisions,2WKB6@28221|Deltaproteobacteria,2MHNH@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_86813_1 1121405.dsmv_0433 8.08e-71 229.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MIGA@213118|Desulfobacterales 28221|Deltaproteobacteria T CheY-like receiver, AAA-type ATPase, and DNA-binding - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_184459_2 1408423.JHYA01000002_gene605 2.54e-05 48.1 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,4H55S@909932|Negativicutes 909932|Negativicutes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_184459_3 1123228.AUIH01000065_gene3063 2.19e-11 60.5 2ENZF@1|root,33GKB@2|Bacteria,1NGMD@1224|Proteobacteria,1SHNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxin SymE, type I toxin-antitoxin system - - - ko:K19048 - - - - ko00000,ko02048 - - - SymE_toxin k59_184459_4 63737.Npun_R0130 8.28e-43 143.0 2E0F1@1|root,32W1E@2|Bacteria,1G6H6@1117|Cyanobacteria,1HSDE@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_15113_1 555088.DealDRAFT_0641 3.22e-21 99.0 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia 186801|Clostridia J tRNA nucleotidyltransferase poly(A) polymerase - - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_184460_1 743299.Acife_2329 2.29e-70 224.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,1RQ7I@1236|Gammaproteobacteria,2NDSK@225057|Acidithiobacillales 225057|Acidithiobacillales L PFAM Integrase, catalytic core - - - - - - - - - - - - HTH_32 k59_190659_1 1121396.KB892913_gene163 4.8e-102 313.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MHKE@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_203518_1 935261.JAGL01000003_gene3122 1.02e-44 164.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,43IGX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_99482_1 1049564.TevJSym_ad01120 0.0 1080.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_112823_1 986075.CathTA2_2616 7.23e-25 107.0 COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4HDXV@91061|Bacilli 91061|Bacilli T His Kinase A (phosphoacceptor) domain atoS - 2.7.13.3 ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_41923_2 177439.DP2835 4.63e-26 109.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MU2@68525|delta/epsilon subdivisions,2WM00@28221|Deltaproteobacteria,2MKCR@213118|Desulfobacterales 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_177773_1 1000565.METUNv1_02217 4.44e-78 256.0 COG5339@1|root,COG5339@2|Bacteria,1R5PZ@1224|Proteobacteria,2VMEJ@28216|Betaproteobacteria,2KUUE@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - - - - - - - - - - DUF945 k59_22268_2 398767.Glov_0875 1.55e-93 287.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Ion transport 2 domain protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_196676_2 768671.ThimaDRAFT_2042 1.13e-33 120.0 COG2920@1|root,COG2920@2|Bacteria,1N6BZ@1224|Proteobacteria,1S8YA@1236|Gammaproteobacteria,1WYWH@135613|Chromatiales 135613|Chromatiales P TIGRFAM sulfur relay protein, TusE DsrC DsvC family - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_196676_3 870187.Thini_2202 9.82e-88 264.0 COG1309@1|root,COG1309@2|Bacteria,1RHNC@1224|Proteobacteria,1SB4M@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_67373_1 1232437.KL662020_gene705 2.54e-13 69.7 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_106184_1 1121405.dsmv_1685 3.25e-75 233.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MJ9I@213118|Desulfobacterales 28221|Deltaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,CoA_binding,Ligase_CoA k59_35166_1 1049564.TevJSym_ad00540 5.15e-66 204.0 COG0852@1|root,COG0852@2|Bacteria,1RB4M@1224|Proteobacteria,1S3KE@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_35166_2 1049564.TevJSym_ad00530 1.69e-92 275.0 COG0377@1|root,COG0377@2|Bacteria,1Q273@1224|Proteobacteria,1S0ZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM NADH Ubiquinone - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_203527_1 1121918.ARWE01000001_gene2905 2.13e-36 133.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_203527_2 1121918.ARWE01000001_gene2906 1.52e-34 131.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_158106_1 243233.MCA0936 2.34e-287 824.0 COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,1RMM0@1236|Gammaproteobacteria,1XFCE@135618|Methylococcales 135618|Methylococcales L helicase Cas3 - - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD k59_190668_1 1121405.dsmv_1924 5.39e-184 518.0 COG0620@1|root,COG0620@2|Bacteria,1QB3M@1224|Proteobacteria,42NP4@68525|delta/epsilon subdivisions,2WK9Z@28221|Deltaproteobacteria,2MJ74@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - - - - - - - - - - - k59_67379_1 1249627.D779_0628 3.52e-184 521.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_41939_1 1049564.TevJSym_am00320 1.78e-96 293.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1J9H8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E FAD dependent oxidoreductase thiO GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_54239_1 1219049.SP5_069_00840 8.44e-56 190.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2TW3A@28211|Alphaproteobacteria,2K3JQ@204457|Sphingomonadales 204457|Sphingomonadales C Respiratory nitrate reductase beta C-terminal - - - - - - - - - - - - Fer4_11,Nitr_red_bet_C k59_177779_1 1122201.AUAZ01000043_gene1279 6.19e-186 544.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,46A76@72275|Alteromonadaceae 1236|Gammaproteobacteria P Sodium:sulfate symporter transmembrane region yfbS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_86833_2 7994.ENSAMXP00000021622 3.79e-06 48.5 COG0384@1|root,KOG3033@2759|Eukaryota,39RJ0@33154|Opisthokonta,3B96X@33208|Metazoa,3CSSR@33213|Bilateria,489W8@7711|Chordata,49924@7742|Vertebrata,49YFT@7898|Actinopterygii 33208|Metazoa S Phenazine biosynthesis-like PBLD GO:0001894,GO:0001932,GO:0001933,GO:0003008,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0007586,GO:0008150,GO:0008285,GO:0009892,GO:0009966,GO:0009968,GO:0010563,GO:0010605,GO:0010632,GO:0010633,GO:0010646,GO:0010648,GO:0010669,GO:0010717,GO:0010719,GO:0017015,GO:0019220,GO:0019222,GO:0022600,GO:0023051,GO:0023057,GO:0030277,GO:0030334,GO:0030336,GO:0030512,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032501,GO:0032879,GO:0040012,GO:0040013,GO:0042127,GO:0042325,GO:0042326,GO:0042592,GO:0042802,GO:0044424,GO:0044464,GO:0045595,GO:0045596,GO:0045936,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048871,GO:0050678,GO:0050680,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051171,GO:0051172,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051248,GO:0051270,GO:0051271,GO:0060249,GO:0060255,GO:0060390,GO:0060392,GO:0060393,GO:0060394,GO:0065007,GO:0065008,GO:0080090,GO:0090092,GO:0090101,GO:0090287,GO:0090288,GO:1903844,GO:1903845,GO:2000026,GO:2000145,GO:2000146 - - - - - - - - - - PhzC-PhzF k59_112841_1 340177.Cag_1333 2.06e-50 174.0 COG1947@1|root,COG1947@2|Bacteria,1FDN3@1090|Chlorobi 1090|Chlorobi F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_28521_4 870187.Thini_0913 2.45e-92 276.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,460GU@72273|Thiotrichales 72273|Thiotrichales H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_28521_5 1049564.TevJSym_ad00690 1.78e-202 568.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1J4CF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0516,iJN746.PP_3813 DHBP_synthase,GTP_cyclohydro2 k59_28521_6 1049564.TevJSym_ad00700 2.76e-86 256.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1J5Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0380 DMRL_synthase k59_35168_1 269799.Gmet_0852 8.04e-156 449.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43TNC@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_35168_2 1121405.dsmv_0961 5.67e-12 65.1 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKCK@213118|Desulfobacterales 28221|Deltaproteobacteria U Preprotein translocase subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_41945_1 1049564.TevJSym_av00340 6.74e-38 133.0 COG3149@1|root,COG3149@2|Bacteria,1PSQ5@1224|Proteobacteria,1SX0C@1236|Gammaproteobacteria,1J77X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins - - - ko:K02462 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSM k59_67629_1 311403.Arad_9023 2.37e-195 553.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U28T@28211|Alphaproteobacteria,4BE1X@82115|Rhizobiaceae 28211|Alphaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_147193_1 177437.HRM2_24840 1.01e-79 246.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria,2MJB6@213118|Desulfobacterales 28221|Deltaproteobacteria O Tellurite resistance protein TerB - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_37262_1 1232437.KL662077_gene1889 5.39e-22 92.8 COG4871@1|root,COG4871@2|Bacteria,1R2X6@1224|Proteobacteria,43DHK@68525|delta/epsilon subdivisions,2X8PD@28221|Deltaproteobacteria,2MPQA@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786,FeS k59_82464_1 1121439.dsat_0894 1.25e-109 332.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2M9K4@213115|Desulfovibrionales 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_160235_1 349521.HCH_02554 5.45e-47 169.0 COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,1XJ1E@135619|Oceanospirillales 135619|Oceanospirillales T Domain of unknown function (DUF4118) - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD k59_140392_1 795359.TOPB45_0873 1.71e-33 124.0 COG0725@1|root,COG0725@2|Bacteria,2GIAT@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_11 k59_69734_1 675817.VDA_001033 3.87e-26 110.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales 135623|Vibrionales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_114626_1 768671.ThimaDRAFT_2843 1.11e-24 118.0 COG1289@1|root,COG1289@2|Bacteria,1MX9H@1224|Proteobacteria,1RSD7@1236|Gammaproteobacteria,1WXR6@135613|Chromatiales 135613|Chromatiales S Fusaric acid resistance protein - - - - - - - - - - - - FUSC k59_16937_1 566466.NOR53_547 7.53e-142 414.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_192440_1 876044.IMCC3088_635 1.02e-85 263.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase catalytic - - - - - - - - - - - - HTH_23,LZ_Tnp_IS481,rve k59_49978_1 933262.AXAM01000008_gene1943 3.53e-229 663.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase large chain oligomerisation carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_44502_1 439235.Dalk_1330 2.69e-54 183.0 COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_101357_1 177437.HRM2_48490 1.01e-60 202.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MJIJ@213118|Desulfobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_24225_1 331869.BAL199_05389 1.88e-10 64.7 COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1Q2DV@1224|Proteobacteria,2VB2I@28211|Alphaproteobacteria,4BT60@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Type III secretion system lipoprotein chaperone (YscW) - - - - - - - - - - - - META,YscW k59_96131_4 269796.Rru_A0481 1.04e-73 255.0 COG1752@1|root,COG1752@2|Bacteria,1N5JZ@1224|Proteobacteria,2UENP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - - k59_96131_5 1499967.BAYZ01000009_gene5372 1.85e-95 311.0 COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_96131_6 395494.Galf_1309 6.75e-29 119.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_147207_1 1123508.JH636449_gene7275 1.02e-06 55.5 COG0457@1|root,COG0457@2|Bacteria,2IZWD@203682|Planctomycetes 203682|Planctomycetes KLT COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16 k59_205296_1 1304885.AUEY01000002_gene381 1.66e-46 169.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2MHUC@213118|Desulfobacterales 28221|Deltaproteobacteria U type II and III secretion system protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_192446_2 1049564.TevJSym_ad00650 1.11e-46 162.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,1RP8G@1236|Gammaproteobacteria,1J5NJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_37278_1 1049564.TevJSym_ap00510 3.66e-103 318.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_88745_2 671065.MetMK1DRAFT_00004860 3.7e-07 54.7 COG3335@1|root,arCOG02129@2157|Archaea 2157|Archaea L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_3 k59_88745_3 489825.LYNGBM3L_18340 7.86e-18 85.1 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G0GB@1117|Cyanobacteria,1H89N@1150|Oscillatoriales 1117|Cyanobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_32,HTH_33 k59_172699_1 485916.Dtox_3192 1.58e-32 120.0 COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,2629C@186807|Peptococcaceae 186801|Clostridia J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_128475_1 702113.PP1Y_AT11408 1.43e-197 572.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1R7EM@1224|Proteobacteria,2UPM6@28211|Alphaproteobacteria,2K9IJ@204457|Sphingomonadales 204457|Sphingomonadales C PQQ-like domain - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ k59_128475_2 566461.SSFG_02796 8.46e-20 93.6 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family gbsA - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_179710_1 439235.Dalk_4738 2.07e-57 201.0 COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_24229_1 765911.Thivi_1973 9.75e-107 326.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_30429_1 1070319.CAGGBEG34_310029 4.6e-77 251.0 COG1061@1|root,COG1199@1|root,COG1061@2|Bacteria,COG1199@2|Bacteria,1MWW0@1224|Proteobacteria,2VVFN@28216|Betaproteobacteria,1KE51@119060|Burkholderiaceae 28216|Betaproteobacteria KL HELICc2 - - - - - - - - - - - - DEAD,Helicase_C_2 k59_114637_1 713587.THITH_05265 3.91e-08 60.1 COG1680@1|root,COG1680@2|Bacteria,1PGQT@1224|Proteobacteria,1SWR7@1236|Gammaproteobacteria,1X19R@135613|Chromatiales 135613|Chromatiales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_3945_2 631362.Thi970DRAFT_00674 9.99e-132 395.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_153511_1 335543.Sfum_2055 1.67e-78 240.0 COG5340@1|root,COG5340@2|Bacteria,1P6MT@1224|Proteobacteria,42SXD@68525|delta/epsilon subdivisions,2WP1U@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_4 k59_153511_2 118173.KB235910_gene4782 3.07e-66 214.0 COG2253@1|root,COG2253@2|Bacteria,1GBWG@1117|Cyanobacteria,1HF22@1150|Oscillatoriales 1117|Cyanobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_121987_1 1283300.ATXB01000001_gene1722 3.48e-13 74.3 COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria K esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin,cNMP_binding k59_63175_1 933262.AXAM01000038_gene898 3.14e-70 220.0 COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales 28221|Deltaproteobacteria D PFAM Cobyrinic acid ac-diamide synthase - - - ko:K07321 - - - - ko00000 - - - CbiA k59_88937_2 1121875.KB907546_gene2238 1.43e-45 155.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_37472_1 1265505.ATUG01000002_gene1896 2.18e-36 136.0 COG2308@1|root,COG2308@2|Bacteria,1NG4H@1224|Proteobacteria,42WK0@68525|delta/epsilon subdivisions,2WS0X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_198616_2 1167006.UWK_03533 1.81e-39 139.0 COG2033@1|root,COG2033@2|Bacteria,1N615@1224|Proteobacteria 1224|Proteobacteria C Desulfoferrodoxin - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox k59_50142_1 335543.Sfum_2413 6.24e-36 138.0 COG3523@1|root,COG3523@2|Bacteria,1NRHK@1224|Proteobacteria,42Z87@68525|delta/epsilon subdivisions,2WTYM@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_147387_1 177437.HRM2_27280 1.4e-42 156.0 COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2MIS0@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,TSP_3,VWA,VWA_2 k59_4130_1 96561.Dole_2782 9.81e-73 230.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_30589_4 1121468.AUBR01000037_gene1334 4.07e-13 78.6 COG0641@1|root,COG0641@2|Bacteria,1V0HK@1239|Firmicutes,2497U@186801|Clostridia,42GS2@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S single cluster domain - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_17168_1 1006000.GKAS_03749 2.79e-36 138.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSI4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium zraS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_2 k59_17168_2 1121396.KB893012_gene4015 1.51e-117 350.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_4131_1 706587.Desti_3892 2.6e-46 160.0 COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H k59_63351_1 522373.Smlt0084 8.45e-56 187.0 COG0671@1|root,COG0671@2|Bacteria,1PM2D@1224|Proteobacteria,1RQXK@1236|Gammaproteobacteria,1X6C2@135614|Xanthomonadales 135614|Xanthomonadales I Acid phosphatase phoC - 3.1.3.2 ko:K09474 ko00740,ko01100,ko02020,map00740,map01100,map02020 - R00548 RC00017 ko00000,ko00001,ko01000 - - - PAP2 k59_37479_1 1121472.AQWN01000005_gene2481 3.13e-16 79.3 COG1008@1|root,COG1008@2|Bacteria,1UHSH@1239|Firmicutes,24AAH@186801|Clostridia,260F5@186807|Peptococcaceae 186801|Clostridia C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342,ko:K05575 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_37479_2 1121405.dsmv_1985 1.23e-39 147.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MPT5@213118|Desulfobacterales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus nuoL-2 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_88944_1 1173025.GEI7407_3366 1.01e-15 75.9 COG0708@1|root,COG0708@2|Bacteria,1G29X@1117|Cyanobacteria,1H92X@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Endonuclease Exonuclease phosphatase xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_88944_2 1121396.KB893068_gene1458 1.36e-35 132.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,42SB8@68525|delta/epsilon subdivisions,2WPKF@28221|Deltaproteobacteria,2MJSC@213118|Desulfobacterales 28221|Deltaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_17169_1 485915.Dret_1796 5.06e-41 151.0 COG0569@1|root,COG0589@1|root,COG0569@2|Bacteria,COG0589@2|Bacteria,1QZ59@1224|Proteobacteria,43CFV@68525|delta/epsilon subdivisions,2WR2F@28221|Deltaproteobacteria,2M9AU@213115|Desulfovibrionales 28221|Deltaproteobacteria PT TrkA-N domain - - - ko:K03499,ko:K09944 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N,Usp k59_108667_1 1307436.PBF_14684 1.56e-84 268.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_24458_1 335543.Sfum_2554 4.63e-14 70.5 COG4967@1|root,COG4967@2|Bacteria,1NI49@1224|Proteobacteria,42X6W@68525|delta/epsilon subdivisions,2WSY4@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_24458_2 879212.DespoDRAFT_01133 1.76e-12 68.6 COG4966@1|root,COG4966@2|Bacteria,1N2NR@1224|Proteobacteria,42TRJ@68525|delta/epsilon subdivisions,2WQQ2@28221|Deltaproteobacteria,2MKHU@213118|Desulfobacterales 28221|Deltaproteobacteria NU pilus assembly protein PilW - - - - - - - - - - - - N_methyl,PilW k59_205474_1 1255043.TVNIR_0253 1.91e-57 191.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_205474_2 1049564.TevJSym_af00690 6.69e-06 47.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria,1J9TP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_101582_1 1121405.dsmv_3759 7.2e-86 262.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WJAM@28221|Deltaproteobacteria,2MIQY@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM ABC 3 transport family - - - ko:K09816,ko:K09819 ko02010,map02010 M00242,M00243 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_37480_1 1380387.JADM01000003_gene2460 4.24e-18 85.5 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1XJ8J@135619|Oceanospirillales 135619|Oceanospirillales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_44770_1 1304883.KI912532_gene810 1.04e-71 223.0 COG4778@1|root,COG4778@2|Bacteria,1MUPB@1224|Proteobacteria,2VQ6N@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphonate C-P lyase system protein PhnL phnL - 2.7.8.37 ko:K05780 ko00440,map00440 - R10185 RC00005,RC00063 ko00000,ko00001,ko01000 - - - ABC_tran k59_44770_2 1304883.KI912532_gene811 3.88e-151 431.0 COG4107@1|root,COG4107@2|Bacteria,1MVRN@1224|Proteobacteria,2VH07@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphonate C-P lyase system protein PhnK phnK - - ko:K05781 - - - - ko00000 - - - ABC_tran,oligo_HPY k59_44770_3 1304883.KI912532_gene812 8.7e-172 484.0 COG3627@1|root,COG3627@2|Bacteria,1MV7T@1224|Proteobacteria,2VIVM@28216|Betaproteobacteria 28216|Betaproteobacteria P Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose phnJ - 4.7.1.1 ko:K06163 ko00440,map00440 - R10204 RC03078,RC03079 ko00000,ko00001,ko01000 - - - PhnJ k59_44770_4 1304883.KI912532_gene813 1.31e-214 599.0 COG3626@1|root,COG3626@2|Bacteria,1MUBA@1224|Proteobacteria,2VJPK@28216|Betaproteobacteria 28216|Betaproteobacteria P Phosphonate metabolism phnI - 2.7.8.37 ko:K06164 ko00440,map00440 - R10185 RC00005,RC00063 ko00000,ko00001,ko01000 - - - PhnI k59_44770_5 357804.Ping_3691 1.91e-38 138.0 COG3625@1|root,COG3625@2|Bacteria,1RHXN@1224|Proteobacteria,1SEC2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM phosphonate metabolism - - 2.7.8.37 ko:K06165 ko00440,map00440 - R10185 RC00005,RC00063 ko00000,ko00001,ko01000 - - - PhnH k59_44770_6 1304883.KI912532_gene815 4.62e-42 144.0 COG3624@1|root,COG3624@2|Bacteria,1N205@1224|Proteobacteria,2VW5Q@28216|Betaproteobacteria 28216|Betaproteobacteria P Phosphonate metabolism protein PhnG - - 2.7.8.37 ko:K06166 ko00440,map00440 - R10185 RC00005,RC00063 ko00000,ko00001,ko01000 - - - PhnG k59_44770_7 292415.Tbd_2297 7.56e-132 380.0 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2VI8W@28216|Betaproteobacteria,1KTHM@119069|Hydrogenophilales 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_44770_8 395494.Galf_2743 6.12e-107 314.0 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria 1224|Proteobacteria P Phosphonate ABC transporter phnE - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_82693_1 290317.Cpha266_0893 3.14e-07 57.4 COG1357@1|root,COG1357@2|Bacteria 2|Bacteria S protein homooligomerization - - - - - - - - - - - - Pentapeptide,TIR_2 k59_166515_1 644282.Deba_1095 7.12e-14 67.8 2EPIN@1|root,33H5A@2|Bacteria,1NNGF@1224|Proteobacteria,42XRM@68525|delta/epsilon subdivisions,2WTF0@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_30612_1 1121405.dsmv_0306 2.08e-15 72.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,42SST@68525|delta/epsilon subdivisions,2WPWN@28221|Deltaproteobacteria,2MK4F@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM PTS system fructose subfamily IIA component - - 2.7.1.191 ko:K02793 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - EIIA-man k59_30612_2 1303518.CCALI_01384 1.35e-15 75.5 COG1660@1|root,COG1660@2|Bacteria 2|Bacteria S GTP binding rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_4143_2 765913.ThidrDRAFT_4348 1.91e-54 185.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,1WY4Q@135613|Chromatiales 135613|Chromatiales V Secretion protein, HlyD - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - HlyD_D23 k59_50166_1 743719.PaelaDRAFT_0553 6.44e-69 225.0 COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,4HCA0@91061|Bacilli,26S26@186822|Paenibacillaceae 91061|Bacilli L DNA repair exonuclease yhaO - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,Metallophos_2 k59_140613_2 1441930.Z042_17780 9.48e-66 207.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,400BU@613|Serratia 1236|Gammaproteobacteria EH Belongs to the PAPS reductase family. CysH subfamily cysH GO:0000103,GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019379,GO:0019419,GO:0044237,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_3025,iECABU_c1320.ECABU_c30290,iECNA114_1301.ECNA114_2793,iECO103_1326.ECO103_3306,iECP_1309.ECP_2736,iECSF_1327.ECSF_2551,iETEC_1333.ETEC_2955,iLF82_1304.LF82_0415,iNRG857_1313.NRG857_13505,iSDY_1059.SDY_2964,ic_1306.c3321 PAPS_reduct k59_17179_1 1049564.TevJSym_bl00230 4.68e-192 547.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1J4PG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - iPC815.YPO1023,iSDY_1059.SDY_3034,iYL1228.KPN_03225 AMIN,Amidase_3,LysM k59_129933_1 395493.BegalDRAFT_3005 2.04e-32 118.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,1S54H@1236|Gammaproteobacteria,462T3@72273|Thiotrichales 72273|Thiotrichales S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_129933_2 745411.B3C1_09902 1.82e-38 134.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1J5R4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_168784_1 335543.Sfum_3743 8.5e-76 240.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2MQRN@213462|Syntrophobacterales 28221|Deltaproteobacteria M TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_168784_2 1379698.RBG1_1C00001G0448 7.09e-13 67.4 COG1136@1|root,COG1136@2|Bacteria,2NP7F@2323|unclassified Bacteria 2|Bacteria V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_97522_1 1049564.TevJSym_ac00730 2.06e-245 682.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_39141_1 671143.DAMO_2869 1.65e-100 316.0 2C99D@1|root,2Z7Y8@2|Bacteria 2|Bacteria S DNA-sulfur modification-associated - - - ko:K19169 - - - - ko00000,ko02048 - - - DndB k59_45730_1 1292020.H483_0115690 6.52e-26 106.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_201419_1 1249627.D779_1804 2.96e-243 673.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_201419_2 768671.ThimaDRAFT_3348 1.63e-87 260.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1WX91@135613|Chromatiales 135613|Chromatiales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_201419_3 1249627.D779_1801 9.39e-147 427.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_162495_2 1049564.TevJSym_as00570 3.03e-135 389.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1RYBE@1236|Gammaproteobacteria,1J9YD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_162495_3 1123401.JHYQ01000036_gene1683 5.5e-64 203.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,460ST@72273|Thiotrichales 72273|Thiotrichales C PFAM cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_162495_4 768671.ThimaDRAFT_2751 1.54e-42 145.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales 135613|Chromatiales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_162495_5 485917.Phep_3648 1.17e-17 79.7 COG4654@1|root,COG4654@2|Bacteria,4NSJC@976|Bacteroidetes,1ITX4@117747|Sphingobacteriia 976|Bacteroidetes C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_162495_6 765912.Thimo_1502 6.55e-37 130.0 COG1833@1|root,COG1833@2|Bacteria,1QMZ1@1224|Proteobacteria,1TKAF@1236|Gammaproteobacteria,1X16M@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF123 - - - - - - - - - - - - DUF123 k59_162495_7 1049564.TevJSym_as00630 5.62e-30 110.0 COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,1S75J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family, UPF0114 - - - - - - - - - - - - UPF0114 k59_457_1 765911.Thivi_3090 1.53e-12 67.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_457_2 765913.ThidrDRAFT_0574 1.05e-59 192.0 COG2054@1|root,COG2054@2|Bacteria,1MZY4@1224|Proteobacteria,1S9PH@1236|Gammaproteobacteria,1X0ZK@135613|Chromatiales 135613|Chromatiales H Amino acid kinase family - - - - - - - - - - - - AA_kinase k59_457_3 1123242.JH636435_gene2546 1.71e-27 108.0 COG0720@1|root,COG0720@2|Bacteria,2IZMP@203682|Planctomycetes 203682|Planctomycetes H COG0720 6-pyruvoyl-tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_457_4 1218084.BBJK01000021_gene2241 2.65e-30 119.0 COG0294@1|root,COG0294@2|Bacteria,1MWM3@1224|Proteobacteria,2VH38@28216|Betaproteobacteria,1K05I@119060|Burkholderiaceae 28216|Betaproteobacteria H dihydropteroate synthase - - - - - - - - - - - - - k59_123576_1 933262.AXAM01000116_gene1520 1.72e-53 178.0 COG0189@1|root,COG0189@2|Bacteria,1RH7D@1224|Proteobacteria,42SDD@68525|delta/epsilon subdivisions,2WPGS@28221|Deltaproteobacteria,2MKA2@213118|Desulfobacterales 28221|Deltaproteobacteria HJ PFAM RimK domain protein ATP-grasp - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_26379_1 933262.AXAM01000013_gene1313 3.28e-117 347.0 COG2768@1|root,COG2768@2|Bacteria,1MXMK@1224|Proteobacteria,42M2Z@68525|delta/epsilon subdivisions,2WIN6@28221|Deltaproteobacteria,2MI71@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF362) - - - ko:K07138 - - - - ko00000 - - - DUF362,Fer4,Fer4_4,Fer4_6,Fer4_7 k59_71725_1 883.DvMF_1151 1.47e-35 132.0 COG0583@1|root,COG0583@2|Bacteria,1N8HZ@1224|Proteobacteria,42REK@68525|delta/epsilon subdivisions,2WNFY@28221|Deltaproteobacteria,2MAQR@213115|Desulfovibrionales 28221|Deltaproteobacteria K Transcriptional regulator, LysR - - - - - - - - - - - - HTH_1,LysR_substrate k59_117097_1 644282.Deba_2616 2.44e-37 143.0 COG2202@1|root,COG2204@1|root,COG3852@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,43BNW@68525|delta/epsilon subdivisions,2X7Z8@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_175405_1 396588.Tgr7_1060 1.64e-62 206.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,1RRBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein required for spore maturation in B.subtilis spmB - - ko:K06374 - - - - ko00000 - - - Gate k59_91190_1 768706.Desor_5079 1.55e-36 138.0 COG2864@1|root,COG2864@2|Bacteria,1V1XF@1239|Firmicutes,24GTD@186801|Clostridia,263XV@186807|Peptococcaceae 186801|Clostridia C PFAM Cytochrome b(N-terminal) b6 petB - - - - - - - - - - - - Ni_hydr_CYTB k59_91190_3 1125863.JAFN01000001_gene3327 3.35e-15 82.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_91190_4 1167006.UWK_00556 9.02e-95 293.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1 k59_91190_5 717231.Flexsi_2009 2.29e-65 213.0 COG2864@1|root,COG2864@2|Bacteria,2GERM@200930|Deferribacteres 200930|Deferribacteres C Cytochrome b/b6/petB - - - - - - - - - - - - Ni_hydr_CYTB k59_91190_6 1167006.UWK_00558 3.92e-65 213.0 COG2864@1|root,COG2864@2|Bacteria,1PAKU@1224|Proteobacteria 1224|Proteobacteria C formate dehydrogenase - - - - - - - - - - - - - k59_91190_8 589865.DaAHT2_2115 1.96e-27 117.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria 28221|Deltaproteobacteria C denitrification pathway - - - - - - - - - - - - Ni_hydr_CYTB k59_91190_10 10224.XP_006816166.1 7.02e-17 88.6 KOG2177@1|root,KOG2177@2759|Eukaryota,38EA3@33154|Opisthokonta,3BFJH@33208|Metazoa,3CRTV@33213|Bilateria 33208|Metazoa O Tripartite motif-containing protein - - 2.3.2.27 ko:K11997,ko:K12035 ko05206,map05206 - - - ko00000,ko00001,ko01000,ko03019,ko04121 - - - DUF3583,Filamin,NHL,zf-B_box,zf-C3HC4,zf-C3HC4_3,zf-RING_UBOX k59_162504_2 715451.ambt_06360 1.55e-23 95.5 2DQ56@1|root,334T2@2|Bacteria,1QUYU@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4262) - - - - - - - - - - - - DUF4262 k59_13356_1 1249627.D779_3696 0.0 1054.0 COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2TY@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg,SBP_bac_3 k59_13356_2 1278307.KB906982_gene3979 7.19e-172 521.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_13356_4 1122226.AUHX01000004_gene1937 0.000225 44.7 COG2149@1|root,COG2149@2|Bacteria,4NWFQ@976|Bacteroidetes,1I2WP@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF202) - - - ko:K00389 - - - - ko00000 - - - DUF202 k59_463_1 439235.Dalk_4767 3.89e-92 283.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M8C@68525|delta/epsilon subdivisions,2WJIB@28221|Deltaproteobacteria,2MJ5E@213118|Desulfobacterales 28221|Deltaproteobacteria K sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,PAS,Sigma54_activat k59_6944_1 1232410.KI421419_gene2478 3.06e-152 445.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,43RYP@69541|Desulfuromonadales 28221|Deltaproteobacteria C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2763 Aconitase,Aconitase_C k59_188384_1 1121448.DGI_0946 2.32e-54 189.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,42P0H@68525|delta/epsilon subdivisions,2WNW2@28221|Deltaproteobacteria,2M9SG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_13357_1 1167006.UWK_00887 5.39e-129 376.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MHQC@213118|Desulfobacterales 28221|Deltaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_194809_1 439235.Dalk_0814 3.08e-57 186.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MJ7B@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_188391_1 1265505.ATUG01000002_gene2460 9.08e-43 155.0 COG0151@1|root,COG0151@2|Bacteria,1NTMF@1224|Proteobacteria,42YB9@68525|delta/epsilon subdivisions,2WTMZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A k59_19861_1 375286.mma_2780 1.38e-231 640.0 28KRA@1|root,2ZA8W@2|Bacteria,1R7WX@1224|Proteobacteria,2W0N1@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_19861_2 375286.mma_2721 1.31e-282 783.0 28HVV@1|root,2Z820@2|Bacteria,1NMDF@1224|Proteobacteria,2VIVE@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_19861_3 795666.MW7_0980 4.79e-79 241.0 COG5449@1|root,COG5449@2|Bacteria,1PWCX@1224|Proteobacteria,2VP21@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_84696_1 2340.JV46_16700 1.04e-29 119.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1J5FJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0038 Chloride channel protein EriC eriC - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_194811_1 247490.KSU1_D0223 1.49e-86 279.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,2J2QB@203682|Planctomycetes 203682|Planctomycetes C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_13363_2 83406.HDN1F_20890 1.79e-35 140.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_188393_1 926550.CLDAP_17050 2.42e-86 261.0 COG3335@1|root,COG3335@2|Bacteria,2G8EF@200795|Chloroflexi 200795|Chloroflexi L Transposase - - - - - - - - - - - - - k59_26385_1 1116472.MGMO_169c00010 1.65e-218 611.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1XE7S@135618|Methylococcales 135618|Methylococcales S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_26385_3 1166130.H650_13940 5.56e-11 61.2 COG4253@1|root,COG4253@2|Bacteria,1RIP3@1224|Proteobacteria,1RX4T@1236|Gammaproteobacteria,3X44R@547|Enterobacter 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_142976_1 768671.ThimaDRAFT_4006 1.72e-164 473.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales 135613|Chromatiales I Belongs to the thiolase family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_142976_2 768671.ThimaDRAFT_4004 4.34e-196 560.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1WXJS@135613|Chromatiales 135613|Chromatiales I Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_97647_1 1286106.MPL1_11063 1.08e-11 66.2 2DR2Y@1|root,339YA@2|Bacteria,1NHB7@1224|Proteobacteria,1SH0X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_155981_1 1410620.SHLA_3c000380 1.96e-22 97.1 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,4BGN6@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_194813_1 1049564.TevJSym_bt00170 2.48e-145 423.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1J4EF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG1519 3-deoxy-D-manno-octulosonic-acid transferase waaA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417 Glycos_transf_1,Glycos_transf_N k59_175422_1 335543.Sfum_3302 3.32e-130 389.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MR5T@213462|Syntrophobacterales 28221|Deltaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_175422_2 269799.Gmet_1913 6.07e-23 99.8 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,43TYY@69541|Desulfuromonadales 28221|Deltaproteobacteria J PFAM tRNA synthetase, class II (G, H, P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_97654_1 1049564.TevJSym_bl00150 6.99e-193 545.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1J4S0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_65199_1 933262.AXAM01000007_gene2045 3.28e-107 320.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - ko:K22227 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_13365_1 234267.Acid_1198 3.48e-122 371.0 COG1321@1|root,COG1321@2|Bacteria 2|Bacteria K iron dependent repressor nagC - - ko:K02003,ko:K02565,ko:K15545 - M00258 - - ko00000,ko00002,ko02000,ko03000 3.A.1 - - HTH_IclR,MarR,ROK k59_181935_1 523791.Kkor_0463 6.72e-43 143.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1XJJW@135619|Oceanospirillales 135619|Oceanospirillales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_181935_2 1479235.KK366039_gene2492 2.51e-17 80.1 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_65212_2 1232437.KL662047_gene5176 8.77e-29 109.0 COG1309@1|root,COG1309@2|Bacteria,1RG05@1224|Proteobacteria,42RA4@68525|delta/epsilon subdivisions,2WSC5@28221|Deltaproteobacteria,2MPRE@213118|Desulfobacterales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_26389_1 472759.Nhal_3099 4.63e-17 78.2 COG0438@1|root,COG0438@2|Bacteria,1RA8H@1224|Proteobacteria,1S3Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_26389_2 717773.Thicy_0994 2.42e-16 91.7 28KDG@1|root,2Z9ZZ@2|Bacteria,1R86C@1224|Proteobacteria,1RZH2@1236|Gammaproteobacteria,461G5@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_26389_6 435842.HMPREF0848_01422 2.11e-58 191.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase k59_26389_7 1121360.AUAQ01000011_gene698 8.19e-21 95.5 2A46H@1|root,30SRQ@2|Bacteria,2ISTV@201174|Actinobacteria 201174|Actinobacteria S A-factor biosynthesis hotdog domain - - - - - - - - - - - - AfsA k59_130128_1 138119.DSY3301 1.49e-51 182.0 COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,2492T@186801|Clostridia,262BK@186807|Peptococcaceae 186801|Clostridia L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_26400_1 870187.Thini_3228 8.81e-93 284.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,45ZRY@72273|Thiotrichales 72273|Thiotrichales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_201445_2 408672.NBCG_04384 1.6e-22 105.0 COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,4DN5A@85009|Propionibacteriales 201174|Actinobacteria P Bacterial Na+/H+ antiporter B (NhaB) - - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - ArsB,CitMHS k59_13374_1 357808.RoseRS_3876 4.58e-29 119.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG3322@1|root,COG3850@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,COG3322@2|Bacteria,COG3850@2|Bacteria,2GA7M@200795|Chloroflexi,37663@32061|Chloroflexia 32061|Chloroflexia T histidine kinase HAMP region domain protein - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA,PAS_8,Response_reg,dCache_1 k59_104116_1 91464.S7335_738 1.3e-11 65.1 COG0657@1|root,COG0657@2|Bacteria,1G3P7@1117|Cyanobacteria,1H0RI@1129|Synechococcus 1117|Cyanobacteria I Steryl acetyl hydrolase - - 3.1.1.83 ko:K01066,ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_71999_1 756272.Plabr_1752 4.96e-51 178.0 COG2230@1|root,COG4797@1|root,COG2230@2|Bacteria,COG4797@2|Bacteria,2IX32@203682|Planctomycetes 203682|Planctomycetes Q Predicted methyltransferase regulatory domain - - - - - - - - - - - - MethyTransf_Reg,Methyltransf_25,Methyltransf_31 k59_162765_1 396588.Tgr7_2409 2.83e-13 68.9 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,1X19E@135613|Chromatiales 135613|Chromatiales M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_28007_1 358396.C445_11841 3.53e-08 54.7 COG0411@1|root,arCOG00926@2157|Archaea,2XUIF@28890|Euryarchaeota,23TTC@183963|Halobacteria 183963|Halobacteria E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_28007_2 546271.Selsp_0475 5.2e-39 138.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4H223@909932|Negativicutes 909932|Negativicutes E ABC transporter, ATP-binding protein livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_137930_1 1265505.ATUG01000001_gene2976 8.45e-79 239.0 COG0778@1|root,COG0778@2|Bacteria,1REJI@1224|Proteobacteria,42RKQ@68525|delta/epsilon subdivisions,2WNPF@28221|Deltaproteobacteria,2MJUM@213118|Desulfobacterales 28221|Deltaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_157632_1 1437425.CSEC_0806 1.2e-13 73.2 2E7WX@1|root,314JC@2|Bacteria,2JH97@204428|Chlamydiae 204428|Chlamydiae - - - - - - - - - - - - - - - k59_157632_2 465541.ATCJ01000002_gene63 7.79e-08 53.1 2FKGF@1|root,34C3Q@2|Bacteria,2ISDJ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_53772_1 314230.DSM3645_17525 7.96e-28 110.0 COG1741@1|root,COG1741@2|Bacteria,2IX1N@203682|Planctomycetes 203682|Planctomycetes S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin k59_125503_1 566461.SSFG_01822 3.02e-83 262.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_28010_1 1229909.NSED_05680 5.87e-32 124.0 COG0340@1|root,arCOG01940@2157|Archaea,41SI3@651137|Thaumarchaeota 651137|Thaumarchaeota H biotin-(Acetyl-CoA-carboxylase) ligase - - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_8595_1 1286631.X805_11520 1.45e-72 226.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VJXA@28216|Betaproteobacteria,1KK4P@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_34579_1 335543.Sfum_1590 1.22e-51 178.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MR5R@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_151318_1 1522072.IL54_2311 2.93e-132 400.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,2K13S@204457|Sphingomonadales 204457|Sphingomonadales U type IV secretion system - - - - - - - - - - - - CagE_TrbE_VirB k59_125505_1 522772.Dacet_2893 6.64e-12 67.8 COG1167@1|root,COG1167@2|Bacteria,2GF1H@200930|Deferribacteres 200930|Deferribacteres K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - Aminotran_1_2,GntR k59_73192_1 1121440.AUMA01000010_gene317 3.79e-91 292.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482,ko:K10819 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_86363_1 706587.Desti_1351 7.08e-81 247.0 COG0438@1|root,COG0438@2|Bacteria,1RA8H@1224|Proteobacteria,42RMM@68525|delta/epsilon subdivisions,2WNQY@28221|Deltaproteobacteria 28221|Deltaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_190142_1 1151127.KB906331_gene3261 2.08e-12 70.9 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1YRZ2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria MU Transporter - - - - - - - - - - - - OEP k59_171061_2 177437.HRM2_00650 8.41e-43 151.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,42NWV@68525|delta/epsilon subdivisions,2WJWC@28221|Deltaproteobacteria,2MMJE@213118|Desulfobacterales 28221|Deltaproteobacteria C Nitrate reductase, beta subunit narH - 1.7.5.1 ko:K00371,ko:K17051 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - iAF987.Gmet_1021 Fer4_11,Nitr_red_bet_C k59_184128_1 352165.HMPREF7215_1210 1.2e-74 236.0 COG0444@1|root,COG0444@2|Bacteria,3TBWC@508458|Synergistetes 508458|Synergistetes P ABC transporter, ATP-binding protein - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_145004_2 880072.Desac_0373 6.84e-188 558.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MQAY@213462|Syntrophobacterales 28221|Deltaproteobacteria J tRNA nucleotidyltransferase poly(A) polymerase ccaA - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_119191_1 551789.ATVJ01000001_gene1840 0.000561 47.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,43XTH@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Belongs to the ompA family yiaD - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_184129_1 439235.Dalk_5089 4.3e-130 387.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.6.5.3 ko:K00124,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_99181_1 207559.Dde_0722 4.53e-63 216.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2M7Z1@213115|Desulfovibrionales 28221|Deltaproteobacteria V ABC transporter, transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_1901_1 96561.Dole_1719 6.71e-36 141.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_41442_1 439235.Dalk_0397 9.89e-54 184.0 COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - - - - - - - - - - - DisA_N,YbbR k59_60606_2 283699.D172_0301 3.48e-21 85.1 2E5S4@1|root,330GM@2|Bacteria,1NAY4@1224|Proteobacteria,1SEIX@1236|Gammaproteobacteria,2Q4ZX@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_8776_1 768671.ThimaDRAFT_2180 3.45e-59 185.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1WY82@135613|Chromatiales 135613|Chromatiales H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_8776_2 1049564.TevJSym_ac01060 1.95e-235 660.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1J895@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Starch synthase catalytic domain glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_8776_3 78398.KS43_07230 1.21e-48 172.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1MR5R@122277|Pectobacterium 1236|Gammaproteobacteria F Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcSMS35_1347.EcSMS35_4486 PGI k59_112455_1 1232437.KL662008_gene3441 7.99e-38 138.0 COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria,2MJJZ@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H k59_171067_1 1123371.ATXH01000007_gene541 3.12e-20 89.7 COG0119@1|root,COG0119@2|Bacteria,2GHCY@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Cache domain - - - - - - - - - - - - HMGL-like,dCache_1 k59_138075_1 1123399.AQVE01000001_gene671 4.2e-86 264.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,460KX@72273|Thiotrichales 72273|Thiotrichales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_138075_2 1049564.TevJSym_aj00600 1.22e-128 386.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1J4FF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_125677_1 2340.JV46_16330 1.19e-128 378.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1J68F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_93305_1 314345.SPV1_06124 3.31e-92 275.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria 1224|Proteobacteria P Urea carboxylase-associated protein 2 IV02_09290 - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_60608_1 933262.AXAM01000052_gene2016 3.75e-73 232.0 COG2199@1|root,COG3706@2|Bacteria,1R8F2@1224|Proteobacteria,42QMA@68525|delta/epsilon subdivisions,2WKC1@28221|Deltaproteobacteria,2MHN4@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - DUF484,GGDEF k59_86533_1 421531.IX38_07895 3.38e-16 77.0 COG5018@1|root,COG5018@2|Bacteria,4NGIP@976|Bacteroidetes,1I10Q@117743|Flavobacteriia,3ZNIX@59732|Chryseobacterium 976|Bacteroidetes L DNA polymerase III - - - - - - - - - - - - RNase_T k59_190306_3 1123401.JHYQ01000007_gene535 7.72e-20 86.3 COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,1RYSQ@1236|Gammaproteobacteria,460PG@72273|Thiotrichales 72273|Thiotrichales H ABC-type tungstate transport system - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_1906_1 89187.ISM_03760 7.81e-23 101.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2U4EG@28211|Alphaproteobacteria,46P68@74030|Roseovarius 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_53905_1 1049564.TevJSym_ar00500 1.47e-67 212.0 28NN8@1|root,2ZBNM@2|Bacteria,1RC04@1224|Proteobacteria,1S2KF@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_53905_2 314285.KT71_00525 1.2e-19 86.3 2E94J@1|root,333DE@2|Bacteria,1N7Q9@1224|Proteobacteria,1SEA8@1236|Gammaproteobacteria,1J70C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_53905_3 261292.Nit79A3_1089 2.93e-35 126.0 COG3431@1|root,COG3431@2|Bacteria,1NJ7G@1224|Proteobacteria 1224|Proteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE k59_8779_1 335543.Sfum_0986 2.07e-62 196.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,42VFB@68525|delta/epsilon subdivisions,2WRRQ@28221|Deltaproteobacteria,2MRRH@213462|Syntrophobacterales 28221|Deltaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_8779_2 1094980.Mpsy_1311 1.43e-48 163.0 arCOG01778@1|root,arCOG01778@2157|Archaea,2XU6W@28890|Euryarchaeota,2N9ES@224756|Methanomicrobia 224756|Methanomicrobia Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_31 k59_28176_1 715226.ABI_23180 3.94e-49 171.0 2AQV3@1|root,31G39@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_145018_1 933262.AXAM01000022_gene3241 9.7e-42 160.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MJ23@213118|Desulfobacterales 28221|Deltaproteobacteria IQ TIGRFAM Polyketide-type polyunsaturated fatty acid synthase, PfaA - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_14765_1 485914.Hmuk_2671 2.57e-11 66.2 COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,23RXM@183963|Halobacteria 183963|Halobacteria J Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_47549_1 1189612.A33Q_2502 2.34e-08 68.6 COG3291@1|root,COG5295@1|root,COG3291@2|Bacteria,COG5295@2|Bacteria,4NF6Q@976|Bacteroidetes,47KN7@768503|Cytophagia 976|Bacteroidetes GUW candidate b-glycosidase, glycoside hydrolase family 8 protein - - - - - - - - - - - - Beta_helix,Big_3_3,M60-like_N,NosD,Peptidase_M60 k59_99190_1 1049564.TevJSym_an00440 2.4e-101 304.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1J4CX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4967,iYL1228.KPN_03375 S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_112462_1 261292.Nit79A3_2368 1.79e-46 158.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,371UX@32003|Nitrosomonadales 28216|Betaproteobacteria L Exodeoxyribonuclease III xth xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_14766_1 1121405.dsmv_3407 1.93e-20 91.7 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MIUK@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_14766_2 1184267.A11Q_2016 1.61e-09 60.1 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2MSNT@213481|Bdellovibrionales,2WJAQ@28221|Deltaproteobacteria 213481|Bdellovibrionales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8 k59_93319_1 886293.Sinac_4025 5.58e-19 89.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes 203682|Planctomycetes T COG0515 Serine threonine protein - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40 k59_66953_2 1499967.BAYZ01000103_gene3730 5.66e-43 142.0 COG0662@1|root,COG0662@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - ko:K21700 - - - - ko00000 - - - Cupin_2,HTH_18,HTH_AraC k59_196350_1 398579.Spea_2874 1.43e-17 77.8 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,2QAP4@267890|Shewanellaceae 1236|Gammaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iJN746.PP_1602 FabA k59_196350_2 1121405.dsmv_3140 6.22e-47 162.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MI3C@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_171074_1 317025.Tcr_0625 4.42e-36 134.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,4604V@72273|Thiotrichales 72273|Thiotrichales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_171074_2 1049564.TevJSym_ac01900 1e-74 235.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1J5PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_145026_1 356851.JOAN01000002_gene615 1.59e-38 144.0 COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4D93Q@85008|Micromonosporales 201174|Actinobacteria S Mo-co oxidoreductase dimerisation domain - - 1.8.3.1 ko:K00387 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00533 RC00168 ko00000,ko00001,ko01000 - - - Mo-co_dimer,Oxidored_molyb k59_34792_1 497964.CfE428DRAFT_0256 0.000546 46.2 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system frgC - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - GAF_2,HTH_8,Pkinase,Response_reg,Sigma54_activat k59_34792_2 583355.Caka_0795 1.35e-18 85.1 COG0427@1|root,COG0427@2|Bacteria,46TQC@74201|Verrucomicrobia,3K7AC@414999|Opitutae 414999|Opitutae C acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_190313_1 1499967.BAYZ01000078_gene985 7.87e-116 344.0 COG1541@1|root,COG1541@2|Bacteria,2NREC@2323|unclassified Bacteria 2|Bacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_21947_1 1121403.AUCV01000013_gene3920 6.75e-104 322.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MID@68525|delta/epsilon subdivisions,2WJYT@28221|Deltaproteobacteria,2MMWN@213118|Desulfobacterales 28221|Deltaproteobacteria EK helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - Aminotran_1_2,GntR k59_47556_1 273068.TTE2394 1.75e-51 169.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,42G9G@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_66956_1 395493.BegalDRAFT_1677 3.12e-94 297.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent Clp protease ATP-binding subunit ClpA - - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_157803_1 697282.Mettu_1848 4.25e-100 298.0 2DBHY@1|root,2Z9DM@2|Bacteria,1RJGS@1224|Proteobacteria,1S5ZR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HIRAN domain - - - - - - - - - - - - HIRAN k59_157803_2 697282.Mettu_1849 4.33e-122 358.0 COG3550@1|root,COG3550@2|Bacteria,1REBM@1224|Proteobacteria,1S5FD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidyl-serine autophosphorylation - - - - - - - - - - - - HipA_C k59_196352_1 1454004.AW11_00285 5.01e-10 67.0 COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2VHP3@28216|Betaproteobacteria,1KQXD@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_93324_1 1122919.KB905555_gene879 3.82e-99 318.0 COG1643@1|root,COG1643@2|Bacteria,1TPET@1239|Firmicutes,4HE8W@91061|Bacilli,26U7B@186822|Paenibacillaceae 91061|Bacilli L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_41469_1 762376.AXYL_03417 5.18e-15 76.6 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,3T3R1@506|Alcaligenaceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_203211_1 161156.JQKW01000001_gene1414 9.25e-32 119.0 COG2181@1|root,COG2181@2|Bacteria,2GGSV@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - - k59_28185_1 933262.AXAM01000030_gene818 5.5e-70 215.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QQE@68525|delta/epsilon subdivisions,2WNC3@28221|Deltaproteobacteria,2MJJ9@213118|Desulfobacterales 28221|Deltaproteobacteria EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_53913_1 1249627.D779_1971 6.69e-163 472.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales 135613|Chromatiales L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_53915_1 225117.XP_009350076.1 1.19e-62 218.0 COG0050@1|root,COG0480@1|root,KOG0460@2759|Eukaryota,KOG0465@2759|Eukaryota,37K55@33090|Viridiplantae,3G82M@35493|Streptophyta,4JJGU@91835|fabids 35493|Streptophyta J Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_177425_1 1333507.AUTQ01000111_gene1206 2.2e-06 50.8 2EICS@1|root,33C43@2|Bacteria,1NIAI@1224|Proteobacteria,1SGPY@1236|Gammaproteobacteria,2Q2VQ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_80237_2 941449.dsx2_0270 1.1e-22 98.2 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2M843@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Cation transporter ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_101472_2 1392540.P256_01919 2.2e-07 53.1 COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,1S3GK@1236|Gammaproteobacteria,3NJ8C@468|Moraxellaceae 1236|Gammaproteobacteria T Forkhead associated domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_128590_1 1045855.DSC_10680 7.74e-24 94.7 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1X7C1@135614|Xanthomonadales 135614|Xanthomonadales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_128590_2 1265490.JHVY01000005_gene1333 1.36e-81 250.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300 IspD k59_11301_1 1380394.JADL01000003_gene5081 1.46e-47 169.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2JR1T@204441|Rhodospirillales 204441|Rhodospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_19 k59_134421_3 1249627.D779_4121 1.08e-32 123.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWHG@135613|Chromatiales 135613|Chromatiales H Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_88837_2 1122604.JONR01000014_gene252 1.33e-41 146.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1X4HU@135614|Xanthomonadales 135614|Xanthomonadales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_69854_2 713586.KB900536_gene1978 3.3e-27 109.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_192542_1 1049564.TevJSym_as00120 4.29e-25 101.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1J67H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_114742_1 984262.SGRA_2749 4.71e-52 176.0 COG0332@1|root,COG0332@2|Bacteria,4NFIN@976|Bacteroidetes,1IRA1@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_166433_1 1082705.JIBP01000017_gene547 2.91e-10 63.2 COG3149@1|root,COG3149@2|Bacteria,1N8VZ@1224|Proteobacteria 1224|Proteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspM GO:0008150,GO:0009405,GO:0044419,GO:0051704 - ko:K02462 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSM k59_30544_1 1318628.MARLIPOL_09401 4.64e-51 172.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,464SQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_24339_1 1250278.JQNQ01000001_gene2463 2.32e-30 122.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_44670_1 489825.LYNGBM3L_73430 8.69e-28 107.0 2E13D@1|root,32WIT@2|Bacteria,1G8HI@1117|Cyanobacteria,1HCFG@1150|Oscillatoriales 1117|Cyanobacteria S Protein of unknown function VcgC/VcgE (DUF2780) - - - - - - - - - - - - DUF2780 k59_108552_1 56780.SYN_02161 7.12e-95 285.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2MR4I@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_128598_1 439235.Dalk_1240 1.47e-53 178.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MIG1@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_128598_2 96561.Dole_2220 8.91e-37 133.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2MI9R@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_160359_2 1265503.KB905174_gene4289 7.01e-132 399.0 COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1S29W@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0732 Restriction endonuclease S subunits hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_160359_3 561229.Dd1591_3672 1.16e-69 227.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit hsdM GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_205408_1 331678.Cphamn1_1607 5.58e-21 88.2 COG0838@1|root,COG0838@2|Bacteria,1FDY8@1090|Chlorobi 1090|Chlorobi C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_4048_1 933262.AXAM01000006_gene1843 3.05e-43 144.0 2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,42VAC@68525|delta/epsilon subdivisions,2WR6Q@28221|Deltaproteobacteria,2MKKP@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1992) - - - - - - - - - - - - DUF1992 k59_186726_1 584708.Apau_0465 1.16e-48 178.0 COG3464@1|root,COG3464@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_172773_1 1121405.dsmv_2683 1.72e-76 244.0 28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_198561_2 595494.Tola_1952 7.19e-30 117.0 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria,1Y5KU@135624|Aeromonadales 135624|Aeromonadales S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_198561_3 349521.HCH_06614 1.17e-97 307.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1XIUK@135619|Oceanospirillales 135619|Oceanospirillales I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_122114_1 868595.Desca_0101 4.7e-21 93.6 COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,2613S@186807|Peptococcaceae 186801|Clostridia S TIGRFAM MazG family protein mazG - 3.6.1.66 ko:K02428,ko:K02499 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG,TP_methylase k59_147307_1 1121405.dsmv_1952 8.13e-83 264.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,2MJ25@213118|Desulfobacterales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_9,Pyr_redox_2 k59_30545_1 1049564.TevJSym_ah00540 1.82e-35 125.0 COG1580@1|root,COG1580@2|Bacteria,1ND67@1224|Proteobacteria,1SDZM@1236|Gammaproteobacteria,1J7DH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Controls the rotational direction of flagella during chemotaxis - - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_30545_2 765913.ThidrDRAFT_3920 1.52e-110 346.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMV2@1236|Gammaproteobacteria,1WXF8@135613|Chromatiales 135613|Chromatiales T PFAM Chemotaxis methyl-accepting receptor, signalling - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 k59_128602_1 1049564.TevJSym_ai00190 5.07e-67 212.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1J5AA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_128602_2 314278.NB231_09953 6.28e-62 191.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WYPR@135613|Chromatiales 135613|Chromatiales K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_128602_3 1049564.TevJSym_ai00210 1.08e-77 247.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_192560_1 933262.AXAM01000008_gene1975 2.04e-15 75.9 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria,2MJ1W@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidoglycan-binding LysM - - - - - - - - - - - - LysM k59_96289_2 706587.Desti_1266 7.07e-117 347.0 COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,42MPB@68525|delta/epsilon subdivisions,2WJUV@28221|Deltaproteobacteria,2MQZ7@213462|Syntrophobacterales 28221|Deltaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB2 - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_140515_2 483219.LILAB_12420 4.23e-199 567.0 COG2227@1|root,COG2227@2|Bacteria,1R6E0@1224|Proteobacteria,42ZTU@68525|delta/epsilon subdivisions,2WVFC@28221|Deltaproteobacteria,2YZN2@29|Myxococcales 28221|Deltaproteobacteria H RNA repair, ligase-Pnkp-associating, region of Hen1 ubiE2 - - - - - - - - - - - Hen1_L,Methyltransf_23 k59_140515_3 448385.sce2733 0.0 1085.0 COG0639@1|root,COG4639@1|root,COG0639@2|Bacteria,COG4639@2|Bacteria,1Q3Q7@1224|Proteobacteria,4342C@68525|delta/epsilon subdivisions,2X4TK@28221|Deltaproteobacteria,2YZJY@29|Myxococcales 28221|Deltaproteobacteria T PNKP adenylyltransferase domain, ligase domain - - - - - - - - - - - - AAA_33,Metallophos,PNKP-ligase_C,PNKP_ligase k59_55944_1 1324957.K933_06153 1.79e-26 112.0 COG0025@1|root,arCOG01961@2157|Archaea,2XVSR@28890|Euryarchaeota,23SF7@183963|Halobacteria 183963|Halobacteria P COG0025 NhaP-type Na H and K H antiporters - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_179843_1 177437.HRM2_00970 4.72e-27 107.0 COG0462@1|root,COG0462@2|Bacteria,1R2XV@1224|Proteobacteria,42MD5@68525|delta/epsilon subdivisions,2WK1E@28221|Deltaproteobacteria,2MHPM@213118|Desulfobacterales 28221|Deltaproteobacteria EF Phosphoribosyl synthetase-associated domain - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_82797_1 224325.AF_2290 1.53e-50 169.0 COG0123@1|root,arCOG00327@2157|Archaea,2XV92@28890|Euryarchaeota,245W6@183980|Archaeoglobi 183980|Archaeoglobi BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_50306_1 1049564.TevJSym_bd00130 1.08e-80 249.0 COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria 1236|Gammaproteobacteria CF catalyzes the conversion of - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_108818_1 269797.Mbar_A2570 6.78e-44 147.0 COG4119@1|root,arCOG06857@2157|Archaea 2157|Archaea L NUDIX domain - - - - - - - - - - - - NUDIX k59_37620_1 1054217.TALC_01557 1.11e-38 147.0 COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,241KG@183967|Thermoplasmata 183967|Thermoplasmata L MCM OB domain - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_OB k59_11598_2 717231.Flexsi_2009 4.41e-08 57.4 COG2864@1|root,COG2864@2|Bacteria,2GERM@200930|Deferribacteres 200930|Deferribacteres C Cytochrome b/b6/petB - - - - - - - - - - - - Ni_hydr_CYTB k59_128868_1 1232410.KI421418_gene2422 4.3e-70 224.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_50307_1 1430331.EP10_10015 9.97e-11 68.9 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,4H9PI@91061|Bacilli,1WER7@129337|Geobacillus 91061|Bacilli E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_44929_1 1415780.JPOG01000001_gene2740 1.63e-105 331.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1XCEY@135614|Xanthomonadales 135614|Xanthomonadales C Molydopterin dinucleotide binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_96521_1 1049564.TevJSym_as00100 6.29e-62 191.0 COG0316@1|root,COG0316@2|Bacteria,1RFIX@1224|Proteobacteria,1S3SB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the HesB IscA family - - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_96521_2 1049564.TevJSym_as00090 1.31e-156 454.0 COG1232@1|root,COG1232@2|Bacteria,1R5SZ@1224|Proteobacteria,1S0K9@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Protoporphyrinogen oxidase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_96521_3 1198232.CYCME_0358 5.83e-22 92.8 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,4623B@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_108823_1 439235.Dalk_1208 2.04e-47 169.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_89099_1 1357423.S5MBP4_9CAUD 2.77e-84 271.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales 28883|Caudovirales S Ribonucleotide reductase, barrel domain - GO:0003674,GO:0003824,GO:0004748,GO:0008150,GO:0008152,GO:0016491,GO:0016725,GO:0016728,GO:0055114,GO:0061731 - - - - - - - - - - - k59_166658_1 56780.SYN_02177 5.98e-75 239.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,2MQ4I@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_128872_1 1134474.O59_002992 8.59e-34 136.0 COG3509@1|root,COG3693@1|root,COG3509@2|Bacteria,COG3693@2|Bacteria,1R7BZ@1224|Proteobacteria,1S17S@1236|Gammaproteobacteria,1FGVI@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolase family 10 - - - - - - - - - - - - CBM_2,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_43 k59_50314_2 439235.Dalk_2944 2.55e-46 167.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_205627_1 177437.HRM2_40990 7.15e-38 135.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2MIF2@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_122393_1 335543.Sfum_2659 3.44e-26 107.0 COG3287@1|root,COG3287@2|Bacteria,1Q5S5@1224|Proteobacteria,431QC@68525|delta/epsilon subdivisions,2WWE6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_56133_1 319224.Sputcn32_3061 2.21e-69 222.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,2QARW@267890|Shewanellaceae 1236|Gammaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_140784_1 2342.SOPEG_0598 7.5e-13 72.8 COG2369@1|root,COG2369@2|Bacteria,1NYZM@1224|Proteobacteria,1S0WW@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Phage Mu protein F like protein - - - - - - - - - - - - Phage_Mu_F k59_134702_2 1121405.dsmv_2262 3.63e-49 166.0 2DE1J@1|root,2ZK4J@2|Bacteria,1RCD6@1224|Proteobacteria,42QSM@68525|delta/epsilon subdivisions,2WMX8@28221|Deltaproteobacteria,2MJP3@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_11618_1 765914.ThisiDRAFT_2784 5.91e-69 221.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1WW21@135613|Chromatiales 135613|Chromatiales M UTP-glucose-1-phosphate uridylyltransferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_63547_3 1415754.JQMK01000006_gene3795 1.14e-170 538.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,465V0@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat k59_44945_1 1049564.TevJSym_ac01310 7.74e-172 491.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_192792_1 335543.Sfum_0730 4.12e-104 329.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2MQU5@213462|Syntrophobacterales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_153818_1 1437882.AZRU01000074_gene5556 2e-11 65.1 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria,1YFVD@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - BiPBP_C,DUF4124 k59_205635_1 1049564.TevJSym_af00620 6.13e-102 311.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1J4UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_101731_1 1201288.M900_1646 4.55e-39 137.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2MTFX@213481|Bdellovibrionales,2WKG9@28221|Deltaproteobacteria 213481|Bdellovibrionales S PFAM LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_128875_1 543632.JOJL01000006_gene9681 5.7e-76 249.0 COG0596@1|root,COG0596@2|Bacteria,2GMYM@201174|Actinobacteria 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_160660_2 1129374.AJE_11424 8.55e-49 160.0 2ADX9@1|root,313PE@2|Bacteria,1RGY0@1224|Proteobacteria,1S83N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2846) - - - - - - - - - - - - DUF2846 k59_180034_1 288000.BBta_6814 5.61e-271 852.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,3JQV9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_195127_1 335543.Sfum_2387 1.88e-38 144.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2MSKS@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM major facilitator superfamily MFS_1 - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_7349_1 1121405.dsmv_0959 1.31e-106 324.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MIDU@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM ribonuclease, Rne Rng family rne - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_123977_1 1121405.dsmv_0639 8.4e-52 182.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - - k59_65605_1 1249627.D779_0880 3.06e-134 394.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales 135613|Chromatiales T response regulator glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_65605_2 1049564.TevJSym_aq00020 7.42e-66 203.0 2BE3G@1|root,327U6@2|Bacteria,1RI7X@1224|Proteobacteria,1S88B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_13702_1 335543.Sfum_2526 1.57e-56 186.0 COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria,42ZF3@68525|delta/epsilon subdivisions,2WUZY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS k59_26771_2 243233.MCA2166 1.33e-23 97.1 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1XGJ1@135618|Methylococcales 135618|Methylococcales D Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - - k59_110997_1 28258.KP05_10730 6.91e-65 225.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_175744_1 1123355.JHYO01000031_gene1608 2.44e-101 310.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,371HI@31993|Methylocystaceae 28211|Alphaproteobacteria P Reductase C-terminal thcD - 1.14.13.111,1.18.1.3 ko:K00529,ko:K16968 ko00071,ko00360,ko00920,ko01120,ko01220,map00071,map00360,map00920,map01120,map01220 M00545 R02000,R06782,R06783,R09513 RC00098,RC02556 br01602,ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2,Reductase_C k59_175744_2 1123355.JHYO01000031_gene1607 1.97e-49 159.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,36YN4@31993|Methylocystaceae 28211|Alphaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2 k59_175744_3 1123355.JHYO01000031_gene1606 7.01e-212 593.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_175744_4 1123355.JHYO01000031_gene1605 1.38e-112 334.0 COG2207@1|root,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2UAU0@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG2207 AraC-type DNA-binding domain-containing proteins pobR - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,Cupin_2,HTH_18 k59_104467_2 767434.Fraau_0370 8.99e-26 103.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1X3Y2@135614|Xanthomonadales 135614|Xanthomonadales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_156374_1 706587.Desti_5385 4.53e-92 291.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_20165_1 439235.Dalk_2669 2.99e-117 372.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales 28221|Deltaproteobacteria I BadF BadG BcrA BcrD - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_149956_1 1089439.KB902251_gene1628 1.13e-32 122.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,46132@72273|Thiotrichales 72273|Thiotrichales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_78751_1 1234595.C725_2134 5.53e-30 124.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,4BS4D@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain chvG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K14980 ko02020,map02020 M00520 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1 k59_182347_1 2340.JV46_28610 8.66e-20 85.5 COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,1RP91@1236|Gammaproteobacteria,1J6BW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - ko:K03188 - - - - ko00000 - - - UreF k59_182347_2 1226994.AMZB01000101_gene1147 1.61e-111 324.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RP5R@1236|Gammaproteobacteria,1YDRV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG ureG - - ko:K03189 - - - - ko00000 - - - cobW k59_182347_3 2340.JV46_08670 2.8e-73 232.0 COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,1RR9R@1236|Gammaproteobacteria,1J6HA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolase (HAD superfamily) yedP - 2.7.1.31,3.1.3.70 ko:K07026,ko:K15918 ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514,R05790 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_3,S6PP k59_182347_4 857087.Metme_1706 6.31e-66 205.0 COG0454@1|root,COG0456@2|Bacteria,1N009@1224|Proteobacteria,1T54A@1236|Gammaproteobacteria,1XH1R@135618|Methylococcales 135618|Methylococcales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_182347_5 857087.Metme_1705 1.21e-35 123.0 COG4453@1|root,COG4453@2|Bacteria,1PW10@1224|Proteobacteria,1TEV8@1236|Gammaproteobacteria,1XGWH@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_182347_6 1049564.TevJSym_as00530 4.34e-69 212.0 COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,1S29X@1236|Gammaproteobacteria,1JBGN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S CreA protein creA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K05805 - - - - ko00000 - - - CreA k59_169327_2 748658.KB907312_gene1888 1.46e-20 85.9 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,1S9QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS,STAS_2 k59_20169_1 398767.Glov_0892 1.04e-62 204.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_59165_1 933262.AXAM01000030_gene804 4.33e-129 374.0 COG2159@1|root,COG2159@2|Bacteria,1Q0A4@1224|Proteobacteria,42Q9N@68525|delta/epsilon subdivisions,2WJTE@28221|Deltaproteobacteria,2MI7C@213118|Desulfobacterales 28221|Deltaproteobacteria S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_188806_1 1144319.PMI16_04513 1.22e-13 75.9 COG3209@1|root,COG3209@2|Bacteria,1R1SB@1224|Proteobacteria,2W3D6@28216|Betaproteobacteria 2|Bacteria M Salmonella virulence plasmid 65kDa B protein - - - - - - - - - - - - CHB_HEX_C_1,CotH,Flg_new,Fn3_assoc,LRR_5,LTD,Peptidase_S9,SpvB,TcdB_toxin_midN,VCBS k59_143380_1 933262.AXAM01000040_gene1232 1.66e-12 66.2 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_143380_2 933262.AXAM01000040_gene1233 2.04e-77 241.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_195143_1 1121405.dsmv_0058 6.57e-108 325.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42MWF@68525|delta/epsilon subdivisions,2WKAQ@28221|Deltaproteobacteria,2MIMD@213118|Desulfobacterales 28221|Deltaproteobacteria M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_169332_1 1031288.AXAA01000010_gene473 1.82e-62 207.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,36F7Z@31979|Clostridiaceae 186801|Clostridia L Reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_111014_2 5270.UM01028P0 9.25e-12 66.2 COG0432@1|root,KOG4269@1|root,KOG3267@2759|Eukaryota,KOG4269@2759|Eukaryota,38FSR@33154|Opisthokonta,3NVRI@4751|Fungi,3UXTA@5204|Basidiomycota,3N1TW@452284|Ustilaginomycotina 4751|Fungi T GTPase-activator protein for Rho-like GTPases BEM3 GO:0000131,GO:0003674,GO:0005096,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005826,GO:0005856,GO:0005933,GO:0005934,GO:0005937,GO:0005938,GO:0006996,GO:0007010,GO:0007163,GO:0008047,GO:0008150,GO:0008289,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0015629,GO:0016043,GO:0023051,GO:0023057,GO:0030010,GO:0030234,GO:0030427,GO:0030695,GO:0030863,GO:0030864,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032266,GO:0035023,GO:0035024,GO:0035091,GO:0035838,GO:0042995,GO:0043085,GO:0043087,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043332,GO:0043547,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044463,GO:0044464,GO:0046578,GO:0046580,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0051056,GO:0051058,GO:0051286,GO:0051336,GO:0051345,GO:0060589,GO:0065007,GO:0065009,GO:0070938,GO:0071840,GO:0071944,GO:0098772,GO:0099568,GO:0120025,GO:0120038,GO:0120105,GO:1901981,GO:1902531,GO:1902532 - ko:K08773,ko:K19840 ko04011,ko04014,ko05200,ko05212,map04011,map04014,map05200,map05212 - - - ko00000,ko00001,ko04131 - - - PH,PX,RhoGAP k59_201845_1 1307759.JOMJ01000003_gene1159 3.8e-73 228.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42Y75@68525|delta/epsilon subdivisions,2WUKI@28221|Deltaproteobacteria,2M8Y1@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM ABC transporter related - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_104482_1 933262.AXAM01000018_gene1019 6.97e-132 393.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MHY9@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_104482_2 1265505.ATUG01000002_gene1192 1.37e-11 63.5 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_20178_1 637389.Acaty_c2281 4.27e-106 327.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales 225057|Acidithiobacillales P STAS domain - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_162917_3 1079460.ATTQ01000023_gene308 3.4e-52 176.0 COG3271@1|root,COG3271@2|Bacteria,1R6YT@1224|Proteobacteria,2U4I7@28211|Alphaproteobacteria,4BD6X@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phytochelatin synthase - - - - - - - - - - - - Phytochelatin k59_195145_1 316274.Haur_2247 3.16e-22 99.0 COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi,376RY@32061|Chloroflexia 32061|Chloroflexia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_39660_2 32057.KB217483_gene9527 1.13e-108 343.0 COG4467@1|root,COG4467@2|Bacteria,1G4QI@1117|Cyanobacteria,1HPJG@1161|Nostocales 1117|Cyanobacteria S Involved in initiation control of chromosome replication - - - - - - - - - - - - DDE_Tnp_IS66 k59_65621_1 1049564.TevJSym_aq00790 1.86e-112 330.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1J5GG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0019538,GO:0032991,GO:0036211,GO:0042709,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0046777,GO:0071704,GO:1901564,GO:1902494 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0608 CoA_binding,Ligase_CoA k59_65621_2 1122604.JONR01000033_gene31 4.6e-60 194.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1X42V@135614|Xanthomonadales 135614|Xanthomonadales H polyphosphate kinase - - - - - - - - - - - - PPK2 k59_182357_1 1442599.JAAN01000052_gene2663 1.59e-164 479.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,1X5M9@135614|Xanthomonadales 135614|Xanthomonadales L Domain of unknown function (DUF3427) - - - - - - - - - - - - DUF3427,Helicase_C,PLDc_2,ResIII k59_182357_2 411462.DORLON_00791 9.06e-50 166.0 2CWXD@1|root,32T0J@2|Bacteria,1V83I@1239|Firmicutes,25DQF@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - AP2 k59_169336_1 1125863.JAFN01000001_gene1131 8.88e-31 119.0 COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_175769_1 985665.HPL003_03670 2.09e-16 80.5 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26TDT@186822|Paenibacillaceae 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily sigW - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_13706_1 1049564.TevJSym_bg00040 0.0 1607.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1J4ZR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_85078_1 1049564.TevJSym_bu00100 9.36e-81 241.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1J4SH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_85078_2 765913.ThidrDRAFT_1726 5.35e-85 252.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_85078_3 751994.AGIG01000009_gene1056 8.18e-113 329.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1J4Y5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_13707_1 1121468.AUBR01000001_gene592 5.49e-64 209.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_123999_1 292415.Tbd_2577 2.71e-104 310.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KRCD@119069|Hydrogenophilales 119069|Hydrogenophilales G Fructose-1-6-bisphosphatase, N-terminal domain - - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_78777_1 926560.KE387023_gene2392 0.00037 48.9 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1WJ00@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Metal dependent phosphohydrolase - - - - - - - - - - - - GAF,GAF_2,HD,HD_5,PAS_3,PAS_4,PAS_8 k59_33204_1 765913.ThidrDRAFT_3268 6.99e-70 221.0 COG1390@1|root,COG1390@2|Bacteria,1MYFC@1224|Proteobacteria,1S1YK@1236|Gammaproteobacteria,1WWH9@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - - k59_33204_2 765911.Thivi_3987 1.76e-81 243.0 COG0636@1|root,COG0636@2|Bacteria,1RB4B@1224|Proteobacteria,1S2I4@1236|Gammaproteobacteria,1WY0G@135613|Chromatiales 135613|Chromatiales C subunit c - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k59_33204_3 765913.ThidrDRAFT_3266 5.42e-34 129.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RY40@1236|Gammaproteobacteria,1WXJ9@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_175774_1 765913.ThidrDRAFT_3856 2.07e-54 184.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria,1WWDR@135613|Chromatiales 135613|Chromatiales C TIGRFAM Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_175774_2 1122201.AUAZ01000022_gene3070 7e-43 140.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,4693F@72275|Alteromonadaceae 1236|Gammaproteobacteria C 4Fe-4S binding domain fdxN - - - - - - - - - - - Fer4,Fer4_4 k59_52648_1 1279017.AQYJ01000025_gene612 6.87e-105 322.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_149971_2 1049564.TevJSym_ar00340 2.39e-147 448.0 COG1729@1|root,COG1729@2|Bacteria,1MZ7N@1224|Proteobacteria,1T3FY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - - k59_104487_1 933262.AXAM01000029_gene2748 9.25e-113 340.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2MI51@213118|Desulfobacterales 28221|Deltaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1259 ILVD_EDD k59_169345_1 1437824.BN940_09321 2.53e-37 145.0 COG2199@1|root,COG3287@1|root,COG3287@2|Bacteria,COG3706@2|Bacteria,1RF2E@1224|Proteobacteria,2VS5I@28216|Betaproteobacteria,3T64E@506|Alcaligenaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_9 k59_33209_1 1121405.dsmv_0523 5.07e-81 263.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_26807_1 706587.Desti_1336 1.94e-11 61.6 COG2771@1|root,COG2771@2|Bacteria,1NAK1@1224|Proteobacteria,42VEJ@68525|delta/epsilon subdivisions,2WS0Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Protein of unknown function (DUF4019) - - - - - - - - - - - - DUF4019 k59_26807_2 351160.RCIX81 3.64e-38 135.0 COG1600@1|root,arCOG02740@2157|Archaea,2XW8D@28890|Euryarchaeota,2NA8Y@224756|Methanomicrobia 224756|Methanomicrobia C 4Fe-4S double cluster binding domain - - - - - - - - - - - - Fer4_16 k59_26808_1 1379281.AVAG01000031_gene106 2.35e-91 293.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales 28221|Deltaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_143398_1 177437.HRM2_02850 2.18e-20 91.3 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_79044_1 1123399.AQVE01000024_gene2822 6.05e-35 127.0 COG0642@1|root,COG2205@2|Bacteria,1NJKN@1224|Proteobacteria,1SPXY@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Protoglobin - - - - - - - - - - - - Protoglobin k59_79044_2 686340.Metal_2925 2.64e-51 170.0 2AHZA@1|root,318CM@2|Bacteria,1RHH8@1224|Proteobacteria,1S827@1236|Gammaproteobacteria,1XF2N@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_33424_1 857087.Metme_2941 2.61e-184 541.0 COG2199@1|root,COG2203@1|root,COG2703@1|root,COG4191@1|root,COG4936@1|root,COG2203@2|Bacteria,COG2703@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,GGDEF,HAMP,HATPase_c,HWE_HK,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 k59_33424_2 666685.R2APBS1_1019 2.41e-37 130.0 COG3296@1|root,COG3296@2|Bacteria,1N8TC@1224|Proteobacteria,1SEZY@1236|Gammaproteobacteria,1X76D@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4870) - - - ko:K09940 - - - - ko00000 - - - DUF4870 k59_33424_3 765913.ThidrDRAFT_3480 4.3e-103 306.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1T08M@1236|Gammaproteobacteria,1X2M3@135613|Chromatiales 135613|Chromatiales Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_156587_2 1122211.JMLW01000014_gene1127 8.17e-42 155.0 28JFR@1|root,2Z99N@2|Bacteria,1R7C5@1224|Proteobacteria,1RZYU@1236|Gammaproteobacteria,1XJ6G@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_156587_3 1121943.KB900005_gene4010 2.52e-57 181.0 COG3744@1|root,COG3744@2|Bacteria,1RJ4K@1224|Proteobacteria,1SH83@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_156587_4 1178482.BJB45_14405 3.16e-28 103.0 COG4118@1|root,COG4118@2|Bacteria,1NAEH@1224|Proteobacteria 1224|Proteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_156587_5 56780.SYN_00384 7.55e-49 179.0 COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria,4309C@68525|delta/epsilon subdivisions,2WVJ7@28221|Deltaproteobacteria 28221|Deltaproteobacteria L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_156587_6 1158182.KB905020_gene1755 4.85e-75 247.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales 135613|Chromatiales L DEAD DEAH box - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_163111_2 867900.Celly_0975 9.77e-75 233.0 29Z9P@1|root,30M7W@2|Bacteria,4PBTA@976|Bacteroidetes,1IMYA@117743|Flavobacteriia,1FAH9@104264|Cellulophaga 976|Bacteroidetes S Protein of unknown function (DUF3592) - - - - - - - - - - - - DUF3592 k59_47295_7 1005048.CFU_0065 7.03e-193 615.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VMJI@28216|Betaproteobacteria,475DW@75682|Oxalobacteraceae 28216|Betaproteobacteria M RHS Repeat - - - - - - - - - - - - F5_F8_type_C,PAAR_motif,Peptidase_C39,RHS,RHS_repeat k59_1704_1 1249627.D779_2751 4.5e-66 206.0 COG3453@1|root,COG3453@2|Bacteria,1RHZ3@1224|Proteobacteria,1SH6N@1236|Gammaproteobacteria,1X1Z4@135613|Chromatiales 135613|Chromatiales S Putative phosphatase (DUF442) - - - - - - - - - - - - DUF442 k59_112193_1 247490.KSU1_D0184 2.18e-21 95.9 COG1067@1|root,COG1067@2|Bacteria,2J2AD@203682|Planctomycetes 203682|Planctomycetes O AAA domain - - - - - - - - - - - - AAA_32,Lon_C k59_112193_2 909663.KI867150_gene967 6.66e-25 95.1 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MQIW@213462|Syntrophobacterales 28221|Deltaproteobacteria S KH domain - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_137811_2 1458275.AZ34_08270 6.37e-10 62.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4ABWU@80864|Comamonadaceae 28216|Betaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_73074_1 69395.JQLZ01000004_gene676 2.09e-30 115.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2KG89@204458|Caulobacterales 204458|Caulobacterales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_73074_2 768066.HELO_3977 1.24e-35 125.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1XKEP@135619|Oceanospirillales 135619|Oceanospirillales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid dgkA - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_28098_1 1049564.TevJSym_ad00120 5.39e-129 393.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_151391_1 4113.PGSC0003DMT400045027 2.98e-11 66.2 COG1028@1|root,KOG1200@2759|Eukaryota,37J83@33090|Viridiplantae,3GAYA@35493|Streptophyta,44SDH@71274|asterids 35493|Streptophyta Q KR domain - GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0031967,GO:0031975,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0055114 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_60498_1 754331.AEME01000001_gene101 1.07e-37 139.0 COG2197@1|root,COG2197@2|Bacteria,1R4TP@1224|Proteobacteria,1RR98@1236|Gammaproteobacteria,3XPEZ@561|Escherichia 1236|Gammaproteobacteria K Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6) sdiA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - ko:K07782,ko:K15852,ko:K19666,ko:K19734 ko02020,ko02024,ko02026,map02020,map02024,map02026 - - - ko00000,ko00001,ko03000 - - - Autoind_bind,GerE k59_60498_2 90813.JQMT01000001_gene7 8.34e-22 94.0 COG4232@1|root,COG4232@2|Bacteria,1N90P@1224|Proteobacteria,1SFPD@1236|Gammaproteobacteria,462UN@72273|Thiotrichales 72273|Thiotrichales CO Thioredoxin-like - - - - - - - - - - - - Thioredoxin_7 k59_60498_3 1049564.TevJSym_ac01600 1.48e-113 337.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1J7FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_21809_1 1209072.ALBT01000012_gene3294 1.1e-101 314.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,1FI1N@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 k59_21809_2 1049564.TevJSym_ac01010 4.51e-250 699.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1J8KZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_119089_1 1131269.AQVV01000008_gene970 1.62e-46 158.0 COG2077@1|root,COG2077@2|Bacteria 2|Bacteria O thioredoxin peroxidase activity tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_105746_1 439235.Dalk_2933 2.84e-51 179.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_132077_1 342113.DM82_1795 2.47e-139 422.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KDQ8@119060|Burkholderiaceae 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_73245_1 1049564.TevJSym_cq00020 2.71e-204 573.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1J50W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_196248_1 335543.Sfum_0540 1.02e-59 205.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2MQHQ@213462|Syntrophobacterales 28221|Deltaproteobacteria U Secretin and TonB N terminus short domain pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_177291_1 1121459.AQXE01000002_gene1364 1.16e-57 195.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42M8D@68525|delta/epsilon subdivisions,2WJ6E@28221|Deltaproteobacteria,2M8I0@213115|Desulfovibrionales 28221|Deltaproteobacteria C FAD dependent oxidoreductase glpA - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C,Fer2_BFD k59_164142_1 765913.ThidrDRAFT_0780 7.77e-106 320.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1WWC6@135613|Chromatiales 135613|Chromatiales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_21816_1 713586.KB900536_gene1549 1.13e-90 283.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales 135613|Chromatiales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_66861_1 935863.AWZR01000001_gene1706 2.47e-28 114.0 COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,1S57B@1236|Gammaproteobacteria,1X5IY@135614|Xanthomonadales 135614|Xanthomonadales CG Glycosyl transferases, related to UDP-glucuronosyltransferase ugt - - - - - - - - - - - Glyco_transf_28,UDPGT k59_137996_2 1396858.Q666_14440 3.39e-50 162.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,467RP@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1393 Arsenate reductase and related proteins, glutaredoxin family arsC - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_137996_3 1122201.AUAZ01000002_gene894 2.14e-43 147.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,466IM@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_184034_1 596329.HMPREF0631_0795 3.63e-16 83.2 COG2826@1|root,COG2826@2|Bacteria,1TRSF@1239|Firmicutes,248IJ@186801|Clostridia,25THM@186804|Peptostreptococcaceae 186801|Clostridia L Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - HTH_38,rve k59_47490_1 933262.AXAM01000048_gene2598 1.67e-149 431.0 COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,42N6K@68525|delta/epsilon subdivisions,2WKFH@28221|Deltaproteobacteria,2MI37@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1343) - - - - - - - - - - - - DUF1343 k59_99111_1 335543.Sfum_4043 1.88e-166 473.0 COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria,2MQX7@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM sulfite reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr k59_177298_1 667014.Thein_1207 9.84e-48 158.0 COG0669@1|root,COG0669@2|Bacteria,2GHAF@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_203117_1 365046.Rta_33990 2.15e-36 134.0 COG4625@1|root,COG4625@2|Bacteria,1N0QY@1224|Proteobacteria,2VS48@28216|Betaproteobacteria,4AG08@80864|Comamonadaceae 28216|Betaproteobacteria S pathogenesis - - - - - - - - - - - - - k59_203117_2 1121940.AUDZ01000005_gene1719 4.45e-31 114.0 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1XK2W@135619|Oceanospirillales 135619|Oceanospirillales H Molybdenum cofactor biosynthesis protein moaE - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_157717_1 335543.Sfum_4031 6.33e-79 258.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MSIP@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM ABC transporter, transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_157717_2 1307759.JOMJ01000004_gene2845 2.31e-55 179.0 COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,42U8A@68525|delta/epsilon subdivisions,2WPZ6@28221|Deltaproteobacteria,2MCCN@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_73255_1 1249627.D779_1866 5.05e-35 130.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_73255_3 94624.Bpet1991 0.000101 43.9 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,3T1JD@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose ascD - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_60517_1 1049564.TevJSym_ap00410 2.75e-61 206.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1J4NM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_99114_1 1116472.MGMO_44c00380 4.93e-30 112.0 COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,1S271@1236|Gammaproteobacteria,1XEEV@135618|Methylococcales 135618|Methylococcales S small GTP-binding protein - - - ko:K06945 - - - - ko00000 - - - ATP_bind_1 k59_86441_1 1049564.TevJSym_ab01950 1.57e-97 296.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_86441_2 1049564.TevJSym_ab01940 2.98e-77 236.0 COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,1S17V@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_105758_2 1121918.ARWE01000001_gene2854 4.72e-39 139.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,42R5A@68525|delta/epsilon subdivisions,2WN5N@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Cation efflux family catA - - ko:K14696 - - - - ko00000,ko02000 2.A.4.6 - - Cation_efflux,ZT_dimer k59_125613_1 102129.Lepto7375DRAFT_0764 2.17e-43 157.0 COG3464@1|root,COG3464@2|Bacteria,1G9CU@1117|Cyanobacteria,1HGU0@1150|Oscillatoriales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - - k59_41341_1 96561.Dole_0031 5.01e-07 56.2 COG1463@1|root,COG1463@2|Bacteria,1PP5K@1224|Proteobacteria,43EVP@68525|delta/epsilon subdivisions,2WT7Z@28221|Deltaproteobacteria,2MP7C@213118|Desulfobacterales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_119111_1 1049564.TevJSym_ak00730 4.7e-212 596.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_132082_2 1249627.D779_2424 4.98e-38 132.0 2DMJX@1|root,32S2S@2|Bacteria,1N4UR@1224|Proteobacteria,1SBGD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ParD-like antitoxin of type II bacterial toxin-antitoxin system - - - - - - - - - - - - ParD_like k59_132082_3 1249627.D779_2423 2.75e-80 244.0 COG4185@1|root,COG4185@2|Bacteria,1RFDC@1224|Proteobacteria,1SG1X@1236|Gammaproteobacteria,1WZ0T@135613|Chromatiales 135613|Chromatiales S Zeta toxin - - - - - - - - - - - - Zeta_toxin k59_132082_5 76114.ebA2525 5.93e-117 340.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2VKZ3@28216|Betaproteobacteria,2KX0Z@206389|Rhodocyclales 206389|Rhodocyclales L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_66879_1 1124780.ANNU01000043_gene331 5.53e-62 199.0 COG1073@1|root,COG1073@2|Bacteria,4NMZQ@976|Bacteroidetes 976|Bacteroidetes S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_73265_1 439235.Dalk_2281 3.3e-63 210.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42Z00@68525|delta/epsilon subdivisions,2WTI9@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Nickel-dependent hydrogenase - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_203119_2 948106.AWZT01000010_gene2268 2.28e-42 144.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_203119_3 870187.Thini_2368 8.46e-57 179.0 COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Roadblock LC7 family protein - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 k59_203119_4 870187.Thini_2897 1.99e-52 171.0 COG0642@1|root,COG2205@2|Bacteria,1NJKN@1224|Proteobacteria,1SPXY@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Protoglobin - - - - - - - - - - - - Protoglobin k59_47507_1 713586.KB900536_gene2631 4.83e-61 191.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales 135613|Chromatiales P PFAM ApaG domain protein apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_53844_1 323261.Noc_0078 7.08e-19 86.3 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_53844_2 497964.CfE428DRAFT_1128 4.01e-63 219.0 COG4580@1|root,COG4580@2|Bacteria,46V0Y@74201|Verrucomicrobia 74201|Verrucomicrobia G LamB porin - - - ko:K02024 - - - - ko00000,ko02000 1.B.3.1.1 - - LamB k59_53844_3 203122.Sde_3420 9.92e-249 708.0 COG2730@1|root,COG5297@1|root,COG2730@2|Bacteria,COG5297@2|Bacteria,1PY25@1224|Proteobacteria,1SYWJ@1236|Gammaproteobacteria,4666R@72275|Alteromonadaceae 1236|Gammaproteobacteria G CBD_II - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_10,CBM_2,CBM_5_12_2,Cellulase,Glyco_hydro_11 k59_53844_4 521674.Plim_1080 0.0 1103.0 COG0210@1|root,COG1112@1|root,COG0210@2|Bacteria,COG1112@2|Bacteria 2|Bacteria L Superfamily I DNA and RNA helicases and helicase subunits - - - - - - - - - - - - AAA_12,AAA_19 k59_53844_5 1049564.TevJSym_aa00390 1.66e-94 282.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1J4UT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1870_3 94624.Bpet1294 7.02e-39 144.0 28IN9@1|root,2Z8NN@2|Bacteria,1MZG1@1224|Proteobacteria,2WGSB@28216|Betaproteobacteria,3T9ID@506|Alcaligenaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1845) - - - - - - - - - - - - DUF1845 k59_1870_9 94122.Shewana3_0540 1.34e-86 267.0 28M05@1|root,2ZB16@2|Bacteria,1QVZ0@1224|Proteobacteria,1T2NG@1236|Gammaproteobacteria,2QEST@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - YkuI_C k59_93225_1 882378.RBRH_03055 7.68e-20 85.1 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,1K2Q4@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein ycbL - - - - - - - - - - - Lactamase_B k59_93225_2 1049564.TevJSym_bd00070 2.8e-99 292.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_93225_4 631362.Thi970DRAFT_02376 1.31e-38 139.0 COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,1WXXK@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K17230 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001 - - - Cytochrome_CBB3 k59_93225_5 1049564.TevJSym_bd00040 7.1e-75 236.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1J515@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Flavocytochrome c sulphide dehydrogenase, flavin-binding fccB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_99127_1 1121918.ARWE01000001_gene1120 8.7e-45 153.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2WKHY@28221|Deltaproteobacteria,43SDA@69541|Desulfuromonadales 28221|Deltaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_70068_1 398580.Dshi_2295 2.03e-21 94.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_134608_1 96561.Dole_2313 7.37e-157 454.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma-54 interaction domain - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_205535_1 1304885.AUEY01000009_gene1933 4.93e-92 283.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2WJEE@28221|Deltaproteobacteria,2MHM5@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_166590_1 1049564.TevJSym_ar00630 3.79e-68 219.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_179957_1 765913.ThidrDRAFT_0608 3.08e-14 76.6 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,1X2DM@135613|Chromatiales 135613|Chromatiales S Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase k59_179957_2 765913.ThidrDRAFT_0607 2.03e-179 512.0 COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,1RQ5G@1236|Gammaproteobacteria 1236|Gammaproteobacteria E TIGRFAM ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system - - - - - - - - - - - - Peripla_BP_6 k59_179957_3 395965.Msil_0195 3.6e-63 199.0 COG3832@1|root,COG3832@2|Bacteria,1RD9A@1224|Proteobacteria,2U76G@28211|Alphaproteobacteria,3NB7I@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_108747_1 1049564.TevJSym_aw00090 2.9e-119 350.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD dsrP - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_56054_4 857087.Metme_1124 1.13e-184 597.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_56054_5 857087.Metme_1124 6.62e-157 513.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_56054_6 1049564.TevJSym_ar00070 1.7e-69 216.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1J4MN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans k59_179959_1 243265.plu4893 2.88e-57 189.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L IS30 family ISPlu1B - - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_63448_1 1397527.Q670_05870 1.47e-101 307.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1TJAF@1236|Gammaproteobacteria,1XP37@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_147469_1 335543.Sfum_0110 1.37e-35 137.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2MQH0@213462|Syntrophobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_50231_1 945713.IALB_0798 9.31e-08 58.9 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding k59_134616_1 880072.Desac_0499 7.16e-95 290.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_134616_2 880072.Desac_0498 3.69e-30 109.0 2F0YS@1|root,33U0E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_4182_1 1278309.KB907101_gene785 6.18e-32 119.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1XH4I@135619|Oceanospirillales 135619|Oceanospirillales L TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_37543_1 1121405.dsmv_0406 5.82e-91 275.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MIAE@213118|Desulfobacterales 28221|Deltaproteobacteria C May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins nifU - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_70078_1 1123368.AUIS01000006_gene527 2.38e-183 522.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1TB6C@1236|Gammaproteobacteria,2NDKC@225057|Acidithiobacillales 225057|Acidithiobacillales S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_198701_2 933262.AXAM01000066_gene1687 2.28e-50 167.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2MHNJ@213118|Desulfobacterales 28221|Deltaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_166601_1 1121405.dsmv_2307 3.1e-120 356.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_114907_1 335543.Sfum_2600 2.34e-83 260.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MSJJ@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_108758_1 933262.AXAM01000002_gene532 1.99e-52 186.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,2MI31@213118|Desulfobacterales 28221|Deltaproteobacteria M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iAF987.Gmet_2474 OstA,OstA_2,OstA_C k59_24533_1 1049564.TevJSym_ac01980 3.33e-245 679.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,1RRKZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_24533_2 631362.Thi970DRAFT_02374 7.44e-121 372.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_192725_1 1196324.A374_03359 3.41e-52 179.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli 91061|Bacilli S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_198702_1 1121405.dsmv_1427 3.23e-70 220.0 COG2836@1|root,COG2836@2|Bacteria,1PJER@1224|Proteobacteria,43EBU@68525|delta/epsilon subdivisions,2X2D4@28221|Deltaproteobacteria,2MMFS@213118|Desulfobacterales 28221|Deltaproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_101645_3 1304885.AUEY01000003_gene512 4.55e-78 244.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MI6R@213118|Desulfobacterales 28221|Deltaproteobacteria E Pyridoxal-dependent decarboxylase, pyridoxal binding domain lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_24534_1 1492738.FEM21_02040 6.58e-12 70.9 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,1HZEZ@117743|Flavobacteriia,2NU78@237|Flavobacterium 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HTH_AraC,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_11521_1 1123228.AUIH01000091_gene568 6.53e-16 79.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XHYC@135619|Oceanospirillales 135619|Oceanospirillales L recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_75703_1 1232683.ADIMK_0776 5.42e-112 347.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1T0DP@1236|Gammaproteobacteria,469T2@72275|Alteromonadaceae 1236|Gammaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_140694_1 195250.CM001776_gene2532 8.4e-38 143.0 28PII@1|root,2ZC8H@2|Bacteria,1GCST@1117|Cyanobacteria,1H2GQ@1129|Synechococcus 1117|Cyanobacteria S Protein of unknown function (DUF4255) - - - - - - - - - - - - DUF4255 k59_153739_1 96561.Dole_0034 5.67e-39 148.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MHQU@213118|Desulfobacterales 28221|Deltaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_122299_1 1348657.M622_00600 2.08e-28 108.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_101650_1 1121406.JAEX01000005_gene2870 1.66e-42 148.0 COG2204@1|root,COG2204@2|Bacteria,1RCHU@1224|Proteobacteria,42QWT@68525|delta/epsilon subdivisions,2WN23@28221|Deltaproteobacteria,2MAFK@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg,STAS,STAS_2 k59_166610_1 706587.Desti_2042 6.4e-156 453.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_147484_1 747365.Thena_0425 3.03e-59 193.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales 186801|Clostridia G PFAM Transketolase tktA2 - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_96465_2 1049564.TevJSym_at00640 9.75e-253 699.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J4I3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_24538_1 177437.HRM2_00300 2.02e-07 48.9 2ET10@1|root,33KJ8@2|Bacteria,1NM0I@1224|Proteobacteria,42XRS@68525|delta/epsilon subdivisions,2WTDQ@28221|Deltaproteobacteria,2MMCN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_24538_2 247490.KSU1_C0538 7.26e-50 166.0 COG1741@1|root,COG1741@2|Bacteria,2IXVU@203682|Planctomycetes 203682|Planctomycetes S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_101873_9 1370122.JHXQ01000018_gene74 2.65e-12 67.8 2BMD6@1|root,335GT@2|Bacteria,1R6PT@1224|Proteobacteria,2VGFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_101873_15 1278073.MYSTI_01927 9.31e-05 43.1 2EICU@1|root,33C46@2|Bacteria,1NGMA@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2635) - - - - - - - - - - - - DUF2635 k59_101873_16 1150626.PHAMO_340057 5.68e-43 161.0 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,2TRBB@28211|Alphaproteobacteria,2JPAX@204441|Rhodospirillales 204441|Rhodospirillales S Phage tail sheath protein subtilisin-like domain - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k59_37815_1 1217715.F994_02760 7.36e-22 99.8 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,3NT02@468|Moraxellaceae 1236|Gammaproteobacteria M RHS Repeat - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_24780_3 1120963.KB894491_gene831 2.52e-55 182.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,2Q1D4@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria H COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 ygdL GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0030955,GO:0031402,GO:0031420,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0061503,GO:0061504,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_153926_1 431947.PGN_1637 3.58e-25 101.0 COG3404@1|root,COG3404@2|Bacteria,4NN2J@976|Bacteroidetes,2FPSN@200643|Bacteroidia,22XZX@171551|Porphyromonadaceae 976|Bacteroidetes E Methenyltetrahydrofolate cyclohydrolase fchA - - - - - - - - - - - FTCD_C,Peptidase_M78 k59_153926_2 948106.AWZT01000010_gene2268 4.11e-19 82.4 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_45122_1 177437.HRM2_11880 2.79e-93 292.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MMMK@213118|Desulfobacterales 28221|Deltaproteobacteria C Molydopterin dinucleotide binding domain - - 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_147748_1 1316936.K678_11925 8.8e-17 84.0 COG1600@1|root,COG1600@2|Bacteria,1NG2H@1224|Proteobacteria,2UMVW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_187148_1 1121396.KB893079_gene816 1.23e-78 245.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2MHYF@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_166874_1 546267.NEIPOLOT_00720 1.46e-52 171.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,2KPV0@206351|Neisseriales 206351|Neisseriales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_166874_2 930169.B5T_03634 6.21e-17 78.6 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XJNP@135619|Oceanospirillales 135619|Oceanospirillales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_70362_1 1232410.KI421424_gene1693 5.39e-95 283.0 COG5012@1|root,COG5012@2|Bacteria,1PXID@1224|Proteobacteria,42R7Q@68525|delta/epsilon subdivisions,2WN2K@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Methionine synthase B12-binding module cap domain protein - - - - - - - - - - - - B12-binding,B12-binding_2 k59_70362_2 1244869.H261_12381 2.56e-178 512.0 COG0407@1|root,COG0407@2|Bacteria,1R9IN@1224|Proteobacteria 1224|Proteobacteria H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_160842_1 1415775.U729_94 5.05e-20 93.6 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24BBP@186801|Clostridia,36VG6@31979|Clostridiaceae 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg k59_160842_2 1232429.CBLL010000081_gene2105 8.46e-10 65.5 COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,1W81S@1268|Micrococcaceae 201174|Actinobacteria I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_101884_1 926550.CLDAP_11770 3.56e-24 105.0 COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi 200795|Chloroflexi L PFAM Transposase IS66 family - - - - - - - - - - - - - k59_45125_1 227377.CBU_0276 1.24e-52 186.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RQ07@1236|Gammaproteobacteria 1236|Gammaproteobacteria C One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase rubB - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Pyr_redox_2,Rubredoxin k59_45125_2 545276.KB898728_gene169 1.29e-40 138.0 COG3439@1|root,COG3439@2|Bacteria,1NMII@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_45125_3 1439940.BAY1663_05082 1.37e-32 124.0 COG1960@1|root,COG1960@2|Bacteria 2|Bacteria I acyl-CoA dehydrogenase activity - - - - - - - - - - - - Acyl-CoA_dh_N k59_109038_1 391615.ABSJ01000052_gene1252 2.54e-58 182.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1J65P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_134861_1 1121451.DESAM_20704 9.9e-66 219.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2M93H@213115|Desulfovibrionales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_198990_1 153721.MYP_3608 1.31e-07 58.5 COG0642@1|root,COG2205@2|Bacteria,4NG0Y@976|Bacteroidetes,47JUV@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_53138_1 1049564.TevJSym_bb00140 1.13e-150 430.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG4972 Tfp pilus assembly protein, ATPase PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_137300_1 1049564.TevJSym_ax00440 8.16e-07 47.8 COG1974@1|root,COG1974@2|Bacteria,1QUQ8@1224|Proteobacteria,1T20V@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_137300_2 1249627.D779_0089 1.28e-93 293.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_20747_1 96561.Dole_0503 2.45e-92 280.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,42MZM@68525|delta/epsilon subdivisions,2WJG6@28221|Deltaproteobacteria,2MJ01@213118|Desulfobacterales 28221|Deltaproteobacteria S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_20747_2 1121405.dsmv_0304 1.65e-29 109.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2MKBM@213118|Desulfobacterales 28221|Deltaproteobacteria GT PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_111565_1 56780.SYN_00527 1.14e-65 216.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQB7@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_202361_1 1380391.JIAS01000013_gene3782 1.42e-97 333.0 COG3755@1|root,COG3755@2|Bacteria,1R2G9@1224|Proteobacteria,2TZJP@28211|Alphaproteobacteria,2JZ28@204441|Rhodospirillales 204441|Rhodospirillales S Lysozyme inhibitor LprI - - - - - - - - - - - - LprI k59_163391_1 314345.SPV1_12637 3.23e-70 231.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria 1224|Proteobacteria L DNA helicase recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_124573_1 1174528.JH992898_gene4707 6.58e-62 207.0 COG4467@1|root,COG4467@2|Bacteria,1G4QI@1117|Cyanobacteria,1JJ9H@1189|Stigonemataceae 1117|Cyanobacteria L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_79388_1 1121413.JMKT01000016_gene52 1.21e-29 107.0 2EBU9@1|root,335TV@2|Bacteria,1NEIU@1224|Proteobacteria,42V7Y@68525|delta/epsilon subdivisions,2WRJ1@28221|Deltaproteobacteria,2MDRW@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_189435_1 1232437.KL662031_gene2606 1e-27 102.0 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MKI6@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the UPF0109 family - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_92454_1 694431.DESACE_07500 1.6e-113 333.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,42PYG@68525|delta/epsilon subdivisions,2WIRC@28221|Deltaproteobacteria,2M6VM@213113|Desulfurellales 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_131447_2 1163617.SCD_n02328 1.08e-45 152.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria 28216|Betaproteobacteria J chain release factor yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_131447_3 701176.VIBRN418_15763 2.55e-09 57.4 COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,1RYVV@1236|Gammaproteobacteria,1Y2IE@135623|Vibrionales 135623|Vibrionales I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_85846_2 613026.HRAG_00094 1.75e-14 77.4 COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions 1224|Proteobacteria S conserved protein - - - ko:K01163 - - - - ko00000 - - - DUF2156 k59_1404_1 1089551.KE386572_gene1293 1.6e-42 151.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,4BPR9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_8088_2 195253.Syn6312_1171 5.22e-13 70.9 2EPH2@1|root,33H3P@2|Bacteria,1GGI7@1117|Cyanobacteria 1117|Cyanobacteria S protein B3ORF37 Bacteriophage B3 gi 33338631 gb AAQ13955.1 - - - - - - - - - - - - DUF2190 k59_8088_3 1429916.X566_01485 3.78e-53 180.0 28H88@1|root,2Z7K7@2|Bacteria,1R5AY@1224|Proteobacteria,2TSW5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S to capsid protein Bacteriophage B3 gi 33338632 gb AAQ13956.1 - - - - - - - - - - - - - k59_92457_1 203122.Sde_2864 7.41e-65 201.0 COG0317@1|root,COG0317@2|Bacteria,1N2BZ@1224|Proteobacteria,1SB8N@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - HD_4 k59_92457_2 1031711.RSPO_c00021 1.52e-30 109.0 2EQP0@1|root,33I8Y@2|Bacteria,1NJWY@1224|Proteobacteria,2W69V@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_92457_3 1415754.JQMK01000006_gene3789 3.65e-76 240.0 2DMTX@1|root,32TP0@2|Bacteria,1N2JP@1224|Proteobacteria,1SB3B@1236|Gammaproteobacteria,46AVY@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - Ntox24 k59_183312_1 1131266.ARWQ01000004_gene1454 3.89e-74 231.0 COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) lysZ - - ko:K05828 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09776,R10930 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_170403_1 933262.AXAM01000078_gene1614 2.99e-59 185.0 COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,42REM@68525|delta/epsilon subdivisions,2WNMG@28221|Deltaproteobacteria,2MJT7@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM HNH endonuclease - - - - - - - - - - - - HNH k59_157167_1 1304880.JAGB01000001_gene848 1.53e-78 246.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_137542_2 1121396.KB893064_gene1181 8.93e-50 188.0 COG5412@1|root,COG5412@2|Bacteria,1PGYD@1224|Proteobacteria,430I1@68525|delta/epsilon subdivisions,2WW20@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_137542_3 748280.NH8B_1554 4.63e-96 319.0 COG1639@1|root,COG3852@1|root,COG1639@2|Bacteria,COG3852@2|Bacteria,1R444@1224|Proteobacteria,2VJPB@28216|Betaproteobacteria,2KS3Y@206351|Neisseriales 206351|Neisseriales T HDOD domain - - - - - - - - - - - - HATPase_c,HDOD k59_137542_4 1123399.AQVE01000068_gene1053 1.49e-38 132.0 2DTAR@1|root,33JFR@2|Bacteria,1P86J@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_137542_5 1160718.SU9_31146 6.42e-51 167.0 2DKP5@1|root,32UFC@2|Bacteria,2H28I@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - DUF2867 k59_137542_6 870187.Thini_2201 2.06e-10 60.1 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,4602F@72273|Thiotrichales 72273|Thiotrichales S ABC1 family - - - - - - - - - - - - ABC1 k59_8089_2 666681.M301_1890 1.03e-56 185.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VYPK@28216|Betaproteobacteria,2KMQ0@206350|Nitrosomonadales 206350|Nitrosomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_92463_1 909663.KI867150_gene35 8.15e-71 221.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2WP9I@28221|Deltaproteobacteria,2MRKK@213462|Syntrophobacterales 28221|Deltaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_163690_1 316274.Haur_2653 9.01e-47 162.0 COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,37722@32061|Chloroflexia 32061|Chloroflexia E PFAM DAHP synthetase I KDSA - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_144440_1 471854.Dfer_1720 1.07e-85 266.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,47Q96@768503|Cytophagia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_144440_2 94624.Bpet4109 1.75e-51 167.0 2BJSR@1|root,32E4W@2|Bacteria,1RH3N@1224|Proteobacteria,2W200@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2778) - - - - - - - - - - - - DUF2778 k59_189713_5 1123252.ATZF01000001_gene1574 2.92e-06 56.6 COG0419@1|root,COG0419@2|Bacteria,1V1S1@1239|Firmicutes,4HM9B@91061|Bacilli,27BGZ@186824|Thermoactinomycetaceae 91061|Bacilli L AAA domain - - - - - - - - - - - - AAA_23 k59_118494_1 472759.Nhal_0359 1.38e-75 238.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1WW7E@135613|Chromatiales 135613|Chromatiales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_118494_2 765911.Thivi_0162 8.19e-81 245.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,1WXG3@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_118494_3 1247963.JPHU01000001_gene1844 3.98e-56 183.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2TR4Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the WrbA family - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_118494_4 301.JNHE01000006_gene1149 4.65e-37 130.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S3RF@1236|Gammaproteobacteria,1YDBI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Cytochrome B561 yceJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_27556_1 1177154.Y5S_03739 5.4e-56 213.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XNUT@135619|Oceanospirillales 135619|Oceanospirillales M RHS Repeat - - - - - - - - - - - - RHS,RHS_repeat k59_150860_1 941449.dsx2_0363 1.55e-85 278.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2M9PX@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_163692_1 426114.THI_1705 0.000388 41.2 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,1KM26@119065|unclassified Burkholderiales 28216|Betaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_72840_1 1121405.dsmv_3556 3.38e-90 278.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2MJ1N@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_170411_1 1479237.JMLY01000001_gene2918 4.42e-84 262.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,464PS@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_34097_1 85643.Tmz1t_2109 1.71e-18 79.7 COG3668@1|root,COG3668@2|Bacteria,1N7G9@1224|Proteobacteria,2VTCI@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM addiction module toxin, RelE StbE family - - - - - - - - - - - - ParE_toxin k59_34097_2 1247726.MIM_c26220 4.54e-18 77.4 COG3905@1|root,COG3905@2|Bacteria,1N39N@1224|Proteobacteria,2VUG6@28216|Betaproteobacteria 28216|Betaproteobacteria K .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - - - - - - - - - - - k59_34097_3 228410.NE1587 2.65e-13 66.2 COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,2VRK1@28216|Betaproteobacteria,37351@32003|Nitrosomonadales 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - ko:K18831 - - - - ko00000,ko02048,ko03000 - - - HTH_3,Peptidase_M78 k59_34097_5 1396858.Q666_09500 1.85e-53 168.0 COG3668@1|root,COG3668@2|Bacteria,1N7G9@1224|Proteobacteria,1SA9D@1236|Gammaproteobacteria,4693T@72275|Alteromonadaceae 1236|Gammaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_8094_2 1499689.CCNN01000006_gene358 1.81e-105 312.0 COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,36DMA@31979|Clostridiaceae 186801|Clostridia E Glutamate formiminotransferase ftcD - 2.1.2.5 ko:K00603 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R03189 RC00165,RC00221,RC00223,RC00870 ko00000,ko00001,ko01000 - - - FTCD,FTCD_N k59_176682_2 1127673.GLIP_0260 7.54e-31 127.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_40669_1 1049564.TevJSym_bu00040 2.89e-201 599.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_92472_1 1304865.JAGF01000001_gene3757 3.47e-19 87.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria 201174|Actinobacteria V ABC transporter nodI - - ko:K09695 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC_tran k59_137550_1 933262.AXAM01000040_gene1217 2.63e-81 246.0 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MJM3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_1422_1 56780.SYN_00480 3.67e-23 96.7 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Acyl-CoA dehydrogenase - - 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 - R05579 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1422_2 431943.CKL_1719 7.04e-15 75.1 COG3004@1|root,COG3004@2|Bacteria,1TS30@1239|Firmicutes,24AB3@186801|Clostridia,36F1G@31979|Clostridiaceae 186801|Clostridia P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_189719_1 1242864.D187_001517 1.55e-87 270.0 COG1032@1|root,COG1032@2|Bacteria,1RF63@1224|Proteobacteria,42S8Y@68525|delta/epsilon subdivisions,2WNX1@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM k59_72845_1 94122.Shewana3_0433 1.87e-99 315.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,2Q9C2@267890|Shewanellaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006417,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019222,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032787,GO:0034248,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046395,GO:0046459,GO:0046487,GO:0047456,GO:0048037,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0072329,GO:0072350,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:2000112 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0116,iPC815.YPO3415 Aconitase,Aconitase_2_N,Aconitase_B_N k59_163698_1 1086011.HJ01_03555 4.28e-35 133.0 COG3547@1|root,COG3547@2|Bacteria,4NKDC@976|Bacteroidetes,1HXB1@117743|Flavobacteriia,2NV7J@237|Flavobacterium 976|Bacteroidetes L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1423_1 933262.AXAM01000127_gene1028 7.89e-95 287.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM AICARFT IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_66336_1 472759.Nhal_2954 1.7e-23 103.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RQDY@1236|Gammaproteobacteria,1WWGM@135613|Chromatiales 135613|Chromatiales S Cobalamin synthesis protein - - - - - - - - - - - - CobW_C,cobW k59_66336_2 1265505.ATUG01000002_gene1161 1.31e-52 173.0 COG0407@1|root,COG0407@2|Bacteria,1PXIF@1224|Proteobacteria,42SKI@68525|delta/epsilon subdivisions,2WPBF@28221|Deltaproteobacteria,2MKAD@213118|Desulfobacterales 28221|Deltaproteobacteria H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_105247_1 595494.Tola_1846 0.000499 44.3 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,1Y5X0@135624|Aeromonadales 135624|Aeromonadales K LysR substrate binding domain - - - ko:K21703,ko:K21711 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_105247_2 400668.Mmwyl1_3633 1.22e-22 94.7 COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1XHJV@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - ko:K03717 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_53415_1 1121396.KB893094_gene4440 2.43e-132 396.0 COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_144448_1 290397.Adeh_0234 7e-29 125.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42Q14@68525|delta/epsilon subdivisions,2WJ8C@28221|Deltaproteobacteria,2YX9F@29|Myxococcales 28221|Deltaproteobacteria O Belongs to the peptidase S8 family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_124948_1 1121405.dsmv_2039 4.54e-109 317.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria,2MIX9@213118|Desulfobacterales 28221|Deltaproteobacteria C NADPH-dependent FMN reductase wrbA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - iAF987.Gmet_0771 FMN_red k59_170415_1 1049564.TevJSym_ad00670 9.41e-271 760.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1J4YK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG4206 Outer membrane cobalamin receptor protein btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec k59_66500_2 1232437.KL662002_gene4682 4.33e-41 152.0 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WIVN@28221|Deltaproteobacteria,2MIVP@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_112081_1 1051646.VITU9109_10267 7.7e-72 238.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,1Y32Z@135623|Vibrionales 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_170593_1 1121403.AUCV01000001_gene876 1.02e-62 202.0 COG2006@1|root,COG2006@2|Bacteria,1R9FE@1224|Proteobacteria,42QMT@68525|delta/epsilon subdivisions,2WKDC@28221|Deltaproteobacteria,2MJW3@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_105427_1 1049564.TevJSym_au00640 5.31e-55 177.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1J4Y9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_139684_2 1121937.AUHJ01000005_gene2374 3e-42 140.0 COG4456@1|root,COG4456@2|Bacteria,1NA9N@1224|Proteobacteria,1SE0Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Antidote-toxin recognition MazE, bacterial antitoxin - - - ko:K18829 - - - - ko00000,ko02048 - - - MazE_antitoxin k59_139684_3 1121937.AUHJ01000005_gene2375 6.4e-57 179.0 COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,1S4JD@1236|Gammaproteobacteria,469A7@72275|Alteromonadaceae 1236|Gammaproteobacteria S PIN domain vapC - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_68963_1 941449.dsx2_2966 1.76e-09 57.8 COG2210@1|root,COG2210@2|Bacteria,1QZTN@1224|Proteobacteria,436MQ@68525|delta/epsilon subdivisions,2X190@28221|Deltaproteobacteria,2MEHW@213115|Desulfovibrionales 28221|Deltaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_55291_1 1051646.VITU9109_10267 4.7e-41 154.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,1Y32Z@135623|Vibrionales 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_55291_2 1129794.C427_3118 2.96e-24 94.7 COG3377@1|root,COG3377@2|Bacteria,1NDRD@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF1805) - - - - - - - - - - - - DUF1805 k59_55291_3 596154.Alide2_4755 3.03e-82 256.0 COG2964@1|root,COG2964@2|Bacteria,1MUM7@1224|Proteobacteria,2VQPR@28216|Betaproteobacteria,4ADZQ@80864|Comamonadaceae 28216|Betaproteobacteria S YheO-like PAS domain - - - - - - - - - - - - HTH_22,PAS_6 k59_55291_4 1051646.VITU9109_10277 8.65e-82 248.0 2FF77@1|root,34757@2|Bacteria,1NZPM@1224|Proteobacteria,1SSK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_113983_2 1049564.TevJSym_bc00330 7.39e-42 137.0 COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria 1236|Gammaproteobacteria O TIGRFAM hydrogenase assembly chaperone hypC hupF hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_113983_3 395493.BegalDRAFT_1279 3.12e-37 132.0 COG0680@1|root,COG0680@2|Bacteria,1N3AS@1224|Proteobacteria,1SZPN@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Hydrogenase maturation protease - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_113983_4 768671.ThimaDRAFT_0143 4.67e-41 141.0 2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria,1WYS0@135613|Chromatiales 135613|Chromatiales S PFAM HupH hydrogenase expression protein, C-terminal conserved region - - - ko:K03618 - - - - ko00000 - - - HupH_C k59_113983_5 1049564.TevJSym_bc00360 2.53e-227 630.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NiFe/NiFeSe hydrogenase small subunit C-terminal - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_113983_6 1049564.TevJSym_bc00370 6.19e-121 349.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_113983_7 1049564.TevJSym_bc00380 9.04e-254 702.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain dgcB - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_113983_8 1049564.TevJSym_bc00390 0.0 1013.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Nickel-dependent hydrogenase hydB - 1.12.5.1,1.12.99.6 ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_100763_2 1049564.TevJSym_am00020 1.56e-147 431.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,1RS25@1236|Gammaproteobacteria,1J5UR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HDOD domain - - - - - - - - - - - - EAL,HDOD k59_49347_2 1219077.VAZ01S_085_00170 2.49e-45 148.0 2FDU0@1|root,345UN@2|Bacteria,1P19C@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_95496_1 765910.MARPU_02850 4.04e-11 64.3 COG0845@1|root,COG0845@2|Bacteria,1RG7M@1224|Proteobacteria,1S7F9@1236|Gammaproteobacteria,1X0V7@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_95496_2 1454004.AW11_00371 3.69e-30 119.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VJ23@28216|Betaproteobacteria 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_179142_2 279714.FuraDRAFT_1389 1.06e-132 386.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,2KPBZ@206351|Neisseriales 206351|Neisseriales BQ histone deacetylase hda - - - - - - - - - - - Hist_deacetyl k59_179142_3 1049564.TevJSym_aa01700 7.63e-183 522.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1J4T9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2925 Exonuclease I sbcB GO:0000175,GO:0000287,GO:0000738,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008852,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016829,GO:0016835,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0051575,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_146577_2 3750.XP_008385014.1 0.000433 51.2 KOG2532@1|root,KOG2532@2759|Eukaryota,37PDZ@33090|Viridiplantae,3GBXE@35493|Streptophyta,4JDUN@91835|fabids 35493|Streptophyta G anion transporter 6 - GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0009536,GO:0015291,GO:0015318,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0034220,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0098656 - ko:K08193 - - - - ko00000,ko02000 2.A.1.14 - - MFS_1 k59_146577_3 1121456.ATVA01000013_gene1117 4.26e-46 151.0 COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,42WA7@68525|delta/epsilon subdivisions,2WRWX@28221|Deltaproteobacteria,2MCC2@213115|Desulfovibrionales 28221|Deltaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_146577_5 290512.Paes_1634 5.13e-98 304.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1FDRX@1090|Chlorobi 1090|Chlorobi C TIGRFAM nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_146577_7 1458427.BAWN01000018_gene1140 5.07e-117 356.0 COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,4ACES@80864|Comamonadaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine - - 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_146577_8 1280390.CBQR020000102_gene2466 5.35e-11 69.7 COG2227@1|root,COG2227@2|Bacteria,1V9DM@1239|Firmicutes,4IQ8C@91061|Bacilli,2768C@186822|Paenibacillaceae 91061|Bacilli H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_146577_9 1227453.C444_00070 1.5e-13 77.0 COG0500@1|root,arCOG04989@2157|Archaea,2XWEU@28890|Euryarchaeota,23V0C@183963|Halobacteria 183963|Halobacteria Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_25 k59_146577_10 246199.CUS_4695 2.43e-31 132.0 COG2710@1|root,COG2710@2|Bacteria,1TPJX@1239|Firmicutes,24AW6@186801|Clostridia,3WNTA@541000|Ruminococcaceae 186801|Clostridia C Nitrogenase component 1 - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_146577_11 304371.MCP_0903 2.18e-31 134.0 COG2710@1|root,arCOG00591@2157|Archaea,2XXZF@28890|Euryarchaeota,2NBGN@224756|Methanomicrobia 224756|Methanomicrobia C Nitrogenase component 1 type Oxidoreductase - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_146577_12 352165.HMPREF7215_1484 2.01e-82 255.0 COG1348@1|root,COG1348@2|Bacteria,3TC12@508458|Synergistetes 508458|Synergistetes P Belongs to the NifH BchL ChlL family - - - - - - - - - - - - Fer4_NifH k59_146577_13 521460.Athe_0913 4.55e-14 80.5 COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,42FAP@68295|Thermoanaerobacterales 186801|Clostridia C SMART Elongator protein 3 MiaB NifB - - - ko:K22226 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_81869_1 1121405.dsmv_2934 7.91e-138 406.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,42N6D@68525|delta/epsilon subdivisions,2X5IJ@28221|Deltaproteobacteria,2MI9M@213118|Desulfobacterales 28221|Deltaproteobacteria I Carboxyl transferase domain mccB - 6.4.1.4,6.4.1.5 ko:K01969,ko:K13778 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R03494,R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3290 Carboxyl_trans k59_43755_1 1122194.AUHU01000003_gene2408 1.8e-127 399.0 COG3507@1|root,COG3693@1|root,COG5297@1|root,COG3507@2|Bacteria,COG3693@2|Bacteria,COG5297@2|Bacteria,1R7BZ@1224|Proteobacteria,1S17S@1236|Gammaproteobacteria,466TT@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 10 - - - - - - - - - - - - CBM_2,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_43 k59_23570_1 1040989.AWZU01000004_gene7186 2.63e-64 207.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2U0JR@28211|Alphaproteobacteria,3JWTF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07098 - - - - ko00000 - - - Metallophos,Metallophos_2 k59_23570_2 1049564.TevJSym_be00360 1.19e-117 352.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1J5VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction histidine kinase phoQ - 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c,PhoQ_Sensor k59_36611_1 56780.SYN_00973 5.15e-85 266.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MQ9H@213462|Syntrophobacterales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family fgrM - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_95501_1 879212.DespoDRAFT_03171 9.15e-07 48.5 COG3436@1|root,COG3436@2|Bacteria,1MYCD@1224|Proteobacteria,42TEE@68525|delta/epsilon subdivisions,2WPUG@28221|Deltaproteobacteria,2MPR3@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_10575_1 1379281.AVAG01000031_gene106 5.49e-58 202.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales 28221|Deltaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_49358_1 1125863.JAFN01000001_gene3208 1.01e-37 137.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42SXS@68525|delta/epsilon subdivisions,2X5BQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Fic/DOC family - - - - - - - - - - - - Fic,Fic_N k59_185926_1 1049564.TevJSym_aa01670 1.2e-77 235.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1J6R6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_185926_2 85643.Tmz1t_2783 7.01e-05 44.3 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,2KUD3@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_88140_1 1307759.JOMJ01000004_gene2662 9.35e-09 57.4 COG0730@1|root,COG0730@2|Bacteria,1N1I6@1224|Proteobacteria,42N92@68525|delta/epsilon subdivisions,2WJT2@28221|Deltaproteobacteria,2M9Y1@213115|Desulfovibrionales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_23796_2 1049564.TevJSym_ad00440 2.17e-43 143.0 COG1320@1|root,COG1320@2|Bacteria,1NDYS@1224|Proteobacteria,1S972@1236|Gammaproteobacteria 1236|Gammaproteobacteria P monovalent cation proton antiporter, MnhG PhaG subunit - - - - - - - - - - - - PhaG_MnhG_YufB k59_23796_3 1049564.TevJSym_ad00430 5.84e-31 111.0 COG2212@1|root,COG2212@2|Bacteria 2|Bacteria P antiporter activity mrpF - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_23796_4 1049564.TevJSym_ad00420 1.82e-21 86.7 COG1863@1|root,COG1863@2|Bacteria,1QM1G@1224|Proteobacteria,1SEI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Na H ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_36842_2 335543.Sfum_1711 3.34e-101 305.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MQ9T@213462|Syntrophobacterales 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_44045_1 765912.Thimo_0329 3.58e-77 246.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_146800_1 95619.PM1_0226365 1.66e-94 289.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_198131_1 1163617.SCD_n02930 1.59e-93 282.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria 28216|Betaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_133979_2 1049564.TevJSym_au00490 3.57e-87 271.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1J4XM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_204915_2 1266914.ATUK01000011_gene2377 1.93e-14 77.0 COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,1RJQP@1224|Proteobacteria,1SCDJ@1236|Gammaproteobacteria,1X11X@135613|Chromatiales 135613|Chromatiales S Lysin motif - - - - - - - - - - - - LysM,TPR_2,TPR_8 k59_16588_1 1122621.ATZA01000007_gene810 1.69e-19 92.0 COG3385@1|root,COG3385@2|Bacteria,4NHKV@976|Bacteroidetes,1J161@117747|Sphingobacteriia 976|Bacteroidetes L Domain of unknown function (DUF4372) - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_30031_1 56780.SYN_00075 1.65e-38 146.0 COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MR3Q@213462|Syntrophobacterales 28221|Deltaproteobacteria J Pyridoxal-phosphate dependent enzyme cysM - 2.5.1.47,6.1.1.16 ko:K01738,ko:K01883,ko:K12339 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,PALP,tRNA-synt_1e k59_172471_1 396588.Tgr7_0954 8.99e-57 189.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_172471_2 546274.EIKCOROL_00863 2.26e-79 238.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,2KR3R@206351|Neisseriales 206351|Neisseriales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_172471_3 765910.MARPU_02615 2.13e-95 286.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1WWJC@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_172471_4 1049564.TevJSym_au00470 6.7e-148 420.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1J54F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Catabolite gene activator and regulatory subunit of cAMP-dependent protein anr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_153135_2 880072.Desac_1854 4.32e-102 306.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria 2|Bacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small k59_44051_1 177437.HRM2_22100 3.04e-76 256.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_192085_1 216596.RL2444 1.57e-05 47.0 COG4336@1|root,COG4336@2|Bacteria,1MW52@1224|Proteobacteria,2TST8@28211|Alphaproteobacteria,4B8P7@82115|Rhizobiaceae 28211|Alphaproteobacteria S Belongs to the D-glutamate cyclase family MA20_16485 - - - - - - - - - - - DUF1445 k59_179351_2 1049564.TevJSym_as00310 1.77e-90 271.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1J5P4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin k59_133985_1 640511.BC1002_4312 4.08e-09 60.5 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,1K400@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_69226_1 1049564.TevJSym_ac01410 1.9e-77 233.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1J63Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_69226_2 1049564.TevJSym_ac01420 5.3e-130 379.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1J62X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_69226_3 1049564.TevJSym_ac01440 8.25e-53 171.0 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1J6MQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0307 family yjgA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_69226_4 83406.HDN1F_22480 1.95e-223 637.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1J5AY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0608 Single-stranded DNA-specific exonuclease recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_69226_5 1049564.TevJSym_ac01460 1.87e-125 387.0 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1J5XY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Oxygen tolerance batD - - - - - - - - - - - BatD k59_69226_6 1049564.TevJSym_ac01470 6.26e-33 117.0 COG2940@1|root,COG2940@2|Bacteria 2|Bacteria K SET domain CP_0991 - - ko:K07117 - - - - ko00000 - - - SET k59_69226_7 631362.Thi970DRAFT_00663 2.6e-13 67.0 2EA5W@1|root,334AS@2|Bacteria,1NFAR@1224|Proteobacteria,1SE8N@1236|Gammaproteobacteria,1WZB3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_16596_1 335543.Sfum_3013 1.59e-56 199.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Pyr_redox_2 k59_82104_1 1120956.JHZK01000042_gene3046 7.01e-206 586.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2015, Alkyl sulfatase and related hydrolases - - - ko:K01138 - - - - ko00000,ko01000 - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_77595_1 1137799.GZ78_28565 1.21e-66 206.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1XQ07@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - Y1_Tnp k59_77595_3 1225785.CM001983_gene428 1.91e-117 342.0 COG1209@1|root,COG1209@2|Bacteria,1RDR2@1224|Proteobacteria,1S4I7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - - - - - - - - - - NTP_transf_3 k59_77595_4 264198.Reut_A0731 3.72e-68 208.0 COG0241@1|root,COG0241@2|Bacteria,1QWZ2@1224|Proteobacteria,2WH8C@28216|Betaproteobacteria 28216|Betaproteobacteria E D,D-heptose 1,7-bisphosphate phosphatase - - - - - - - - - - - - - k59_77595_5 264198.Reut_A0730 7.67e-242 677.0 COG0510@1|root,COG0510@2|Bacteria,1QWZ1@1224|Proteobacteria,2WH8B@28216|Betaproteobacteria 28216|Betaproteobacteria M thiamine kinase activity - - - - - - - - - - - - - k59_77595_6 264198.Reut_A0729 2.38e-91 280.0 2AM2Q@1|root,31BWR@2|Bacteria,1NQCG@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_77595_7 1225785.CM001983_gene432 9.77e-138 395.0 COG1216@1|root,COG1216@2|Bacteria,1RDAV@1224|Proteobacteria 1224|Proteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_77595_9 335543.Sfum_3763 1.38e-05 47.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria 1224|Proteobacteria L COG3335 Transposase and inactivated derivatives - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32,HTH_33 k59_57852_1 1068980.ARVW01000001_gene4950 2.91e-57 191.0 COG4188@1|root,COG4188@2|Bacteria,2GMYW@201174|Actinobacteria 201174|Actinobacteria S dienelactone hydrolase - - - - - - - - - - - - Chlorophyllase2 k59_136198_2 96561.Dole_0802 1.3e-34 120.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42UFU@68525|delta/epsilon subdivisions,2WR59@28221|Deltaproteobacteria,2MKI0@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_136198_3 96561.Dole_0802 4.59e-08 50.8 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42UFU@68525|delta/epsilon subdivisions,2WR59@28221|Deltaproteobacteria,2MKI0@213118|Desulfobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_51970_1 2340.JV46_15000 5.78e-87 269.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4U6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_6568_1 1304885.AUEY01000031_gene48 5.37e-47 159.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_97322_1 765911.Thivi_2227 1.23e-89 283.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_77920_1 335543.Sfum_0821 6.01e-59 209.0 COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg k59_113_1 335543.Sfum_3201 2.53e-120 360.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MQX4@213462|Syntrophobacterales 28221|Deltaproteobacteria H Belongs to the precorrin methyltransferase family hemD - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase k59_116789_2 1089548.KI783301_gene15 1.55e-39 135.0 COG3436@1|root,COG3436@2|Bacteria,1V7U9@1239|Firmicutes,4HIJB@91061|Bacilli 91061|Bacilli L COG3436 Transposase and inactivated derivatives - - - - - - - - - - - - TnpB_IS66 k59_116789_3 631362.Thi970DRAFT_03189 3.28e-104 332.0 COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria,1WXGD@135613|Chromatiales 135613|Chromatiales L PFAM transposase IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_38976_1 395493.BegalDRAFT_2924 1.24e-57 207.0 COG2198@1|root,COG2198@2|Bacteria,1QY43@1224|Proteobacteria,1S0ZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase fimL - - - - - - - - - - - Hpt k59_64894_1 933262.AXAM01000066_gene1678 8.97e-123 358.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MIIT@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_38980_1 765913.ThidrDRAFT_0780 2.94e-75 240.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1WWC6@135613|Chromatiales 135613|Chromatiales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_19568_1 472759.Nhal_1819 3.43e-33 117.0 COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,1SCHB@1236|Gammaproteobacteria,1WYZC@135613|Chromatiales 135613|Chromatiales P PFAM Na H antiporter subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_19568_2 323261.Noc_1284 2.98e-23 92.4 COG1563@1|root,COG1563@2|Bacteria,1N7YY@1224|Proteobacteria,1SHR3@1236|Gammaproteobacteria,1WZDF@135613|Chromatiales 135613|Chromatiales P Domain of unknown function (DUF4040) - - - - - - - - - - - - DUF4040 k59_45478_1 335543.Sfum_1328 8.11e-121 361.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,43A0M@68525|delta/epsilon subdivisions,2X9UN@28221|Deltaproteobacteria,2MS7U@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red k59_175071_2 1049564.TevJSym_aw00090 1.8e-96 291.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD dsrP - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_19571_1 156889.Mmc1_2606 9.62e-94 290.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2TUXC@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Type III restriction enzyme res subunit - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_58466_2 1049564.TevJSym_ah00340 6.06e-226 636.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4K6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase S1C family mucD GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_58466_3 159087.Daro_2023 4.76e-06 51.2 COG3086@1|root,COG3086@2|Bacteria,1PT8C@1224|Proteobacteria,2VVRE@28216|Betaproteobacteria,2KX89@206389|Rhodocyclales 206389|Rhodocyclales T Positive regulator of sigma(E), RseC/MucC - - - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k59_13060_2 1123228.AUIH01000018_gene3509 3.9e-40 134.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1XIK6@135619|Oceanospirillales 135619|Oceanospirillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_19572_1 644282.Deba_2183 1.93e-55 195.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_162156_1 998674.ATTE01000001_gene1109 6.33e-112 328.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,46076@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase k59_162156_2 1122951.ATUE01000006_gene1280 9.15e-18 81.3 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,3NKGX@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the citrate synthase family prpC GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - iJN746.PP_2335 Citrate_synt k59_194500_1 373994.Riv7116_0611 2.84e-12 63.9 COG1670@1|root,COG1670@2|Bacteria,1GR52@1117|Cyanobacteria 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - 2.3.1.82 ko:K18816 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1 k59_194500_2 298386.PBPRA1917 2.32e-86 259.0 COG1896@1|root,COG1896@2|Bacteria,1MXEZ@1224|Proteobacteria,1RRQQ@1236|Gammaproteobacteria,1XUSC@135623|Vibrionales 135623|Vibrionales S hydrolases of HD superfamily - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_194500_4 1443665.JACA01000047_gene5303 4.27e-15 74.3 COG0500@1|root,COG2226@2|Bacteria,4NXY3@976|Bacteroidetes,1I6ZS@117743|Flavobacteriia,2YGZP@290174|Aquimarina 976|Bacteroidetes Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_23,Methyltransf_31 k59_194500_5 549.BW31_02896 1.03e-37 132.0 COG3791@1|root,COG3791@2|Bacteria,1PSHH@1224|Proteobacteria,1SB5F@1236|Gammaproteobacteria,3W0T5@53335|Pantoea 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_194500_6 94122.Shewana3_3390 1.91e-71 217.0 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S66I@1236|Gammaproteobacteria,2QBPQ@267890|Shewanellaceae 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_194500_9 420662.Mpe_A0870 3.55e-97 295.0 COG0657@1|root,COG0657@2|Bacteria,1MW4D@1224|Proteobacteria,2VIHB@28216|Betaproteobacteria,1KNJG@119065|unclassified Burkholderiales 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_13061_2 1155714.KB891993_gene5832 3.25e-42 149.0 COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria 201174|Actinobacteria C NADPH quinone reductase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_103790_1 1101195.Meth11DRAFT_2524 2.16e-57 186.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,2KM27@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF2063,DUF692 k59_129781_1 339670.Bamb_6476 3.8e-128 419.0 COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae 28216|Betaproteobacteria Q amino acid adenylation domain protein dhbF - - ko:K04784,ko:K04786 ko01053,map01053 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,Hexapep,Hexapep_2,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,Thioesterase,ketoacyl-synt k59_84349_1 1094715.CM001373_gene1013 7.6e-59 197.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1JDTN@118969|Legionellales 118969|Legionellales M Belongs to the peptidase S11 family dacA - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_110295_1 1283300.ATXB01000002_gene3073 2.21e-212 614.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XEFK@135618|Methylococcales 135618|Methylococcales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - 3HCDH,3HCDH_N,ECH_1 k59_110295_2 1049564.TevJSym_bc00270 1.54e-206 583.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1J4GS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_45489_1 1232410.KI421428_gene1178 8.5e-35 130.0 COG0596@1|root,COG0596@2|Bacteria,1RGAP@1224|Proteobacteria,42XWU@68525|delta/epsilon subdivisions,2WSMY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha beta - - - - - - - - - - - - Abhydrolase_1 k59_90880_1 1121405.dsmv_0216 1.08e-78 247.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MINS@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_26071_1 439235.Dalk_3239 4.49e-63 205.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MIIH@213118|Desulfobacterales 28221|Deltaproteobacteria O heat shock protein DnaJ domain protein - - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_116805_1 1121918.ARWE01000001_gene1701 6.91e-42 141.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,42TJ5@68525|delta/epsilon subdivisions,2WQ2Z@28221|Deltaproteobacteria,43UWB@69541|Desulfuromonadales 28221|Deltaproteobacteria H PFAM 6-pyruvoyl tetrahydropterin synthase and queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_149192_1 298386.PBPRA2528 1.21e-47 159.0 2DK54@1|root,32UEC@2|Bacteria,1N1A8@1224|Proteobacteria,1SBNN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_149192_2 298386.PBPRA2368 2.31e-30 116.0 COG0666@1|root,COG0666@2|Bacteria,1P2CN@1224|Proteobacteria,1SSTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S response to abiotic stimulus - - - - - - - - - - - - - k59_155662_1 1049564.TevJSym_bn00050 2.86e-40 141.0 COG2897@1|root,COG2897@2|Bacteria 2|Bacteria P thiosulfate sulfurtransferase activity sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_103798_1 1049564.TevJSym_ah00570 1.72e-52 169.0 COG3945@1|root,COG3945@2|Bacteria,1RBVC@1224|Proteobacteria,1S2ZK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_90885_2 1121035.AUCH01000023_gene3425 1.12e-34 131.0 COG4232@1|root,COG4232@2|Bacteria,1N8UG@1224|Proteobacteria,2VSTK@28216|Betaproteobacteria,2KZFF@206389|Rhodocyclales 206389|Rhodocyclales CO Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbD_2 k59_110302_1 485915.Dret_0599 1.55e-55 196.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_162188_1 1121405.dsmv_3709 3.19e-95 286.0 COG0535@1|root,COG0535@2|Bacteria,1R4SH@1224|Proteobacteria,42NZR@68525|delta/epsilon subdivisions,2WKQA@28221|Deltaproteobacteria,2MHSP@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Radical SAM - - - - - - - - - - - - Fer4_12,Radical_SAM k59_136240_1 207559.Dde_2849 3.68e-159 463.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria,2MBAU@213115|Desulfovibrionales 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_26076_1 1049564.TevJSym_af00930 3.97e-62 204.0 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1RCW6@1224|Proteobacteria,1S3XV@1236|Gammaproteobacteria,1J6BK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD,Response_reg k59_26076_2 493475.GARC_3501 7.42e-22 109.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_13068_1 626887.J057_20790 3.51e-24 99.4 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,4648H@72275|Alteromonadaceae 1236|Gammaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_155672_1 439235.Dalk_5059 5.37e-35 132.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2MHWG@213118|Desulfobacterales 28221|Deltaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_175093_1 765910.MARPU_02145 1.34e-06 48.9 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_175093_2 756272.Plabr_1127 1.81e-26 110.0 COG0338@1|root,COG0338@2|Bacteria,2IZAM@203682|Planctomycetes 203682|Planctomycetes H PFAM D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_201070_1 693444.D782_2373 5.6e-77 243.0 COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives yagA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_194516_1 1121405.dsmv_1984 4.45e-123 365.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MJG3@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_77962_1 1322246.BN4_12484 5.55e-49 178.0 COG4191@1|root,COG4585@1|root,COG5000@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria,COG5000@2|Bacteria,1RB4Z@1224|Proteobacteria,42SHV@68525|delta/epsilon subdivisions,2X7QP@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,PAS_9 k59_116815_1 159087.Daro_1690 1.98e-17 80.5 COG1903@1|root,COG1903@2|Bacteria,1MXU3@1224|Proteobacteria,2VITG@28216|Betaproteobacteria,2KUJC@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_116815_2 159087.Daro_1689 3.51e-253 701.0 COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,2VME3@28216|Betaproteobacteria,2KVCV@206389|Rhodocyclales 206389|Rhodocyclales H precorrin-6y C5,15-methyltransferase - - 2.1.1.132 ko:K00595 ko00860,ko01100,map00860,map01100 - R05149 RC00003,RC01279 ko00000,ko00001,ko01000 - - - Methyltransf_31,PCMT,TP_methylase k59_116815_3 1304883.KI912532_gene991 5.19e-19 83.6 COG2243@1|root,COG2243@2|Bacteria,1MV3G@1224|Proteobacteria,2VK3F@28216|Betaproteobacteria,2KVCN@206389|Rhodocyclales 206389|Rhodocyclales H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_175314_2 1448139.AI20_03870 7.36e-86 281.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1Y455@135624|Aeromonadales 135624|Aeromonadales T Aerotaxis receptor Aer - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_155900_1 933262.AXAM01000010_gene1385 6.38e-47 159.0 COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MK1E@213118|Desulfobacterales 28221|Deltaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_117035_1 933262.AXAM01000085_gene1063 1.07e-85 259.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MI7G@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_97592_1 713586.KB900536_gene203 3.85e-30 116.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_65130_1 390235.PputW619_2044 5.26e-129 377.0 COG1018@1|root,COG1018@2|Bacteria,1MU6E@1224|Proteobacteria,1RNA4@1236|Gammaproteobacteria,1YW7E@136845|Pseudomonas putida group 1236|Gammaproteobacteria C Oxidoreductase FAD-binding domain vanB - - ko:K03863 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_65130_2 95619.PM1_0204495 5.69e-63 203.0 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,1RQ8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit vanA - 1.14.13.82 ko:K03862 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001,ko01000 - - - Rieske k59_194746_1 1142394.PSMK_06300 4.68e-80 259.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_32725_1 933262.AXAM01000013_gene1324 4.39e-168 497.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_194753_1 1089553.Tph_c10760 1.46e-07 58.2 COG1220@1|root,COG1220@2|Bacteria,1TPKQ@1239|Firmicutes,2495P@186801|Clostridia,42FM6@68295|Thermoanaerobacterales 186801|Clostridia O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_400_1 1286631.X805_05890 2.33e-99 297.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1KKA7@119065|unclassified Burkholderiales 28216|Betaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_155917_1 880073.Calab_0413 7.92e-19 88.2 COG3547@1|root,COG3547@2|Bacteria,2NRXZ@2323|unclassified Bacteria 2|Bacteria L COGs COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_149460_1 1049564.TevJSym_av00080 2.88e-48 162.0 2DTN4@1|root,32UVJ@2|Bacteria,1N2A5@1224|Proteobacteria,1SX01@1236|Gammaproteobacteria,1JB3B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_149460_3 1049564.TevJSym_av00100 1.11e-144 412.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNRP@1236|Gammaproteobacteria,1J4J0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG1291 Flagellar motor component pomA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101 - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_149460_4 519989.ECTPHS_02841 8.16e-115 339.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1WWKH@135613|Chromatiales 135613|Chromatiales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_149461_1 1173028.ANKO01000030_gene3320 1.97e-42 165.0 COG0553@1|root,COG0553@2|Bacteria,1G0JK@1117|Cyanobacteria,1H7QU@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Helicase conserved C-terminal domain - - - - - - - - - - - - DUF3883,Helicase_C,SNF2_N k59_52195_1 765912.Thimo_2836 1.99e-67 206.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1WYDZ@135613|Chromatiales 135613|Chromatiales J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_26335_1 579137.Metvu_0945 6.82e-48 172.0 COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,23Q5F@183939|Methanococci 183939|Methanococci G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_168862_1 335543.Sfum_0314 2.2e-126 370.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MRX0@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_58752_1 472759.Nhal_0251 4.12e-130 377.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_119634_3 1049564.TevJSym_aj00400 4.02e-71 217.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1J60Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_132575_1 1454004.AW11_03577 3.15e-27 107.0 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VJXC@28216|Betaproteobacteria,1KQNM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_196707_1 1049564.TevJSym_at00250 8.68e-55 173.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1J7C4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor bigR - - - - - - - - - - - HTH_5 k59_22270_1 1396418.BATQ01000103_gene5522 2.3e-45 160.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1_4 k59_22270_3 1049564.TevJSym_at00200 3.89e-152 442.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RS5D@1236|Gammaproteobacteria,1J70I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_22270_4 1049564.TevJSym_bh00070 4.21e-88 275.0 COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,1RZ5C@1236|Gammaproteobacteria,1J641@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_22270_5 1127673.GLIP_0766 4.11e-26 108.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,469FZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_22270_6 697282.Mettu_1061 0.0 1667.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales 135618|Methylococcales L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_35185_1 1177181.T9A_00418 5.09e-72 224.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1XHTY@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_41973_1 933262.AXAM01000010_gene1383 2.06e-37 130.0 COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MM26@213118|Desulfobacterales 28221|Deltaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_145433_2 765913.ThidrDRAFT_2873 2.25e-46 156.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1WYKN@135613|Chromatiales 135613|Chromatiales L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_86856_1 443143.GM18_1040 2.39e-46 160.0 28NH4@1|root,2ZBJ2@2|Bacteria,1RADQ@1224|Proteobacteria,42UWF@68525|delta/epsilon subdivisions,2X6PD@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_99520_1 335543.Sfum_4074 3.99e-95 290.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2MR7M@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK-1 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_106208_1 1049564.TevJSym_ao00380 9.89e-148 439.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1J9K4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_190706_1 745014.OMB55_00020500 9.89e-30 125.0 COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria,1JB4V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S cellulase activity - - - - - - - - - - - - - k59_119642_1 768671.ThimaDRAFT_4397 1.49e-134 400.0 COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,1MXFN@1224|Proteobacteria,1RMZC@1236|Gammaproteobacteria,1X07M@135613|Chromatiales 135613|Chromatiales G TIGRFAM Phosphotransferase system, fructose IIC component - - - - - - - - - - - - PTS_IIB k59_164558_1 335543.Sfum_1614 2.86e-122 364.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MR3A@213462|Syntrophobacterales 28221|Deltaproteobacteria S VWA containing CoxE family protein - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_22275_1 754477.Q7C_1003 4.17e-92 281.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,45ZNA@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_132585_1 1379281.AVAG01000042_gene818 2.69e-57 192.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,42NIC@68525|delta/epsilon subdivisions,2WKV5@28221|Deltaproteobacteria,2M96W@213115|Desulfovibrionales 28221|Deltaproteobacteria V PFAM secretion protein HlyD - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_80614_1 1123392.AQWL01000005_gene2862 3.27e-27 103.0 COG2920@1|root,COG2920@2|Bacteria,1N6BZ@1224|Proteobacteria,2WCAJ@28216|Betaproteobacteria,1KTBU@119069|Hydrogenophilales 119069|Hydrogenophilales P DsrC like protein - - - - - - - - - - - - DsrC k59_47974_1 981085.XP_010113030.1 1.6e-22 96.3 COG0190@1|root,KOG0089@2759|Eukaryota,37RBW@33090|Viridiplantae,3GD2U@35493|Streptophyta,4JE71@91835|fabids 35493|Streptophyta H Bifunctional protein - GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - - - - - - - - - - THF_DHG_CYH,THF_DHG_CYH_C k59_203558_1 96561.Dole_0844 3.77e-82 254.0 COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales 28221|Deltaproteobacteria L SMART Chromosomal replication initiator DnaA domain - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_196717_2 1232437.KL661985_gene3573 3.37e-60 191.0 COG1633@1|root,COG1633@2|Bacteria,1N36M@1224|Proteobacteria,42UVX@68525|delta/epsilon subdivisions,2WQ53@28221|Deltaproteobacteria,2MMYP@213118|Desulfobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_190710_1 1123393.KB891327_gene469 1.39e-91 280.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2WGSI@28216|Betaproteobacteria 28216|Betaproteobacteria K Sigma-54 interaction domain - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - HTH_8,Sigma54_activat k59_126163_1 243265.plu4893 1.01e-61 201.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L IS30 family ISPlu1B - - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_86865_1 1089550.ATTH01000001_gene302 1.82e-85 270.0 COG4579@1|root,COG4579@2|Bacteria,4NIUY@976|Bacteroidetes 976|Bacteroidetes T Isocitrate dehydrogenase kinase/phosphatase (AceK) - - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_73642_1 879212.DespoDRAFT_03566 5.78e-32 126.0 COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria 1224|Proteobacteria S Involved in initiation control of chromosome replication - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66 k59_61044_1 1463934.JOCF01000044_gene204 4.88e-32 126.0 COG0672@1|root,COG0672@2|Bacteria,2GJ22@201174|Actinobacteria 201174|Actinobacteria P Iron permease FTR1 - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_35186_4 272560.BPSL3270 5.09e-156 445.0 28MWI@1|root,2ZB3T@2|Bacteria,1RAPA@1224|Proteobacteria,2VPKV@28216|Betaproteobacteria,1K1QH@119060|Burkholderiaceae 28216|Betaproteobacteria S Plasmid encoded RepA protein - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - RepA_C k59_196721_1 396588.Tgr7_3088 2.88e-99 292.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,1RR1E@1236|Gammaproteobacteria,1WW97@135613|Chromatiales 135613|Chromatiales S TIGRFAM Urea carboxylase-associated protein 1 - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_184663_1 1049564.TevJSym_as00020 9.62e-19 85.1 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_113027_1 1049564.TevJSym_ak00210 2.95e-80 241.0 COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1J71R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_113027_2 768671.ThimaDRAFT_3388 5.8e-41 158.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1RZ37@1236|Gammaproteobacteria,1WX58@135613|Chromatiales 135613|Chromatiales T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_113027_3 321327.CYA_0467 2.18e-101 299.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1GYT4@1129|Synechococcus 1117|Cyanobacteria C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_126439_2 388399.SSE37_12381 8.52e-140 426.0 COG0542@1|root,COG0542@2|Bacteria,1R8ER@1224|Proteobacteria,2TRK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria O C-terminal, D2-small domain, of ClpB protein - - - - - - - - - - - - AAA_2,ClpB_D2-small k59_151958_1 1121405.dsmv_0179 1.84e-52 172.0 COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,42P41@68525|delta/epsilon subdivisions,2WM40@28221|Deltaproteobacteria,2MN8M@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Uracil-DNA glycosylase superfamily - - - ko:K10800 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_151958_2 1122134.KB893651_gene1805 1.17e-31 118.0 COG3897@1|root,COG3897@2|Bacteria,1RJUI@1224|Proteobacteria,1S6V9@1236|Gammaproteobacteria,1XKCT@135619|Oceanospirillales 135619|Oceanospirillales S COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - - - - - - - - - - - Methyltransf_16,Methyltransf_25 k59_106443_1 857087.Metme_1555 5.69e-61 193.0 2BF77@1|root,328ZR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_106443_2 218491.ECA2891 4.86e-119 348.0 COG4271@1|root,COG4271@2|Bacteria,1RHKG@1224|Proteobacteria,1S6HK@1236|Gammaproteobacteria 1236|Gammaproteobacteria K nucleotide-binding protein - - - - - - - - - - - - TIR-like k59_106443_3 1274374.CBLK010000019_gene2754 8.42e-48 164.0 COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,4HDPM@91061|Bacilli,26RJB@186822|Paenibacillaceae 91061|Bacilli S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt k59_119896_1 713586.KB900536_gene1105 5.44e-31 122.0 COG1653@1|root,COG1653@2|Bacteria,1R5DC@1224|Proteobacteria,1SZEG@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 k59_138648_1 1179778.PMM47T1_28662 7.64e-37 129.0 COG1476@1|root,COG1476@2|Bacteria,1REIS@1224|Proteobacteria,1S4D2@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional - - - - - - - - - - - - HTH_19,HTH_3 k59_138648_2 406818.XBJ1_1288 3.23e-08 54.3 2D1NA@1|root,32TB1@2|Bacteria,1N5E7@1224|Proteobacteria,1SBK5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxin SymE, type I toxin-antitoxin system - - - ko:K19048 - - - - ko00000,ko02048 - - - SymE_toxin k59_113030_1 83406.HDN1F_04720 1.17e-118 363.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_22474_1 1121405.dsmv_1003 4.12e-72 239.0 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales 28221|Deltaproteobacteria I Phosphate acyltransferases - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Acyltransferase,Hydrolase_4 k59_15315_1 518766.Rmar_2140 1.66e-40 144.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,4NS7V@976|Bacteroidetes 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_61256_1 1122981.AUME01000006_gene1692 2.32e-19 81.3 2EHZH@1|root,33BR0@2|Bacteria,4NVDN@976|Bacteroidetes,2FZ4W@200643|Bacteroidia 976|Bacteroidetes S Putative zinc ribbon domain - - - - - - - - - - - - Zn_ribbon_2 k59_61256_3 43989.cce_0689 1.25e-53 196.0 COG2199@1|root,COG3706@2|Bacteria,1GQ6B@1117|Cyanobacteria,3KJAN@43988|Cyanothece 1117|Cyanobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - GGDEF k59_9382_1 349124.Hhal_2361 1.93e-39 146.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales 135613|Chromatiales EI Allophanate hydrolase subunit 1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_9382_2 717785.HYPMC_2343 2.51e-24 96.3 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TU1Z@28211|Alphaproteobacteria,3N8CF@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_145575_1 335543.Sfum_1184 1.3e-76 248.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - - k59_178032_1 429009.Adeg_1585 5.49e-05 46.2 COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,42H8S@68295|Thermoanaerobacterales 186801|Clostridia T Universal stress protein - - - - - - - - - - - - Usp k59_178032_2 706587.Desti_0714 7.89e-164 468.0 COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_132782_1 675817.VDA_000148 1.68e-64 231.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1XV5E@135623|Vibrionales 135623|Vibrionales M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_184674_1 1232437.KL662050_gene5349 7.49e-199 560.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,42MW8@68525|delta/epsilon subdivisions,2WKI6@28221|Deltaproteobacteria,2MIK1@213118|Desulfobacterales 28221|Deltaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phaC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_126455_1 760192.Halhy_3624 7.47e-18 85.5 COG3209@1|root,COG3209@2|Bacteria,4NE5D@976|Bacteroidetes,1IRXE@117747|Sphingobacteriia 976|Bacteroidetes M RHS repeat-associated core domain protein - - - - - - - - - - - - - k59_61259_1 521719.ATXQ01000002_gene2663 7.82e-50 169.0 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1YD7T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain ycfS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0042597,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K16291,ko:K19234,ko:K19235,ko:K19236 ko01503,map01503 - - - ko00000,ko00001,ko01002,ko01011 - - - LysM,YkuD k59_61259_2 697282.Mettu_3195 1.06e-50 176.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XG2F@135618|Methylococcales 135618|Methylococcales D PFAM Cobyrinic acid a,c-diamide synthase - - - - - - - - - - - - AAA_31 k59_73803_1 983544.Lacal_2655 7.36e-22 101.0 COG2304@1|root,COG2304@2|Bacteria,4PKD0@976|Bacteroidetes,1HWKJ@117743|Flavobacteriia 976|Bacteroidetes U Large extracellular alpha-helical protein - - - - - - - - - - - - CHU_C,HYR,LRR_adjacent k59_151970_1 1121403.AUCV01000005_gene206 1.06e-87 258.0 COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42U9N@68525|delta/epsilon subdivisions,2WUT7@28221|Deltaproteobacteria,2MNKF@213118|Desulfobacterales 28221|Deltaproteobacteria S Cupin - - - - - - - - - - - - Cupin_2 k59_126458_1 765914.ThisiDRAFT_1577 6.25e-64 196.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1WYID@135613|Chromatiales 135613|Chromatiales J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_61260_1 289376.THEYE_A1549 1.98e-27 112.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG - - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_113042_1 439235.Dalk_3802 1.26e-35 129.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria,2MK8B@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_190932_1 765910.MARPU_13045 1.33e-67 219.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_94064_1 1392838.AWNM01000004_gene1765 4.69e-54 191.0 COG5281@1|root,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2VIQC@28216|Betaproteobacteria 28216|Betaproteobacteria D tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_94064_2 522306.CAP2UW1_0544 1.24e-32 115.0 COG2161@1|root,COG2161@2|Bacteria,1NBSZ@1224|Proteobacteria,2VWVN@28216|Betaproteobacteria 28216|Betaproteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_94064_3 522306.CAP2UW1_0545 2.51e-62 194.0 COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,2VR6N@28216|Betaproteobacteria,1KR40@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - ko:K07062 - - - - ko00000,ko01000,ko02048 - - - PIN k59_106468_1 349521.HCH_04640 9.62e-15 74.7 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1XRB8@135619|Oceanospirillales 135619|Oceanospirillales T helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_192905_1 1049564.TevJSym_ac01590 9.36e-99 297.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1J5X4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_192905_3 1049564.TevJSym_ac01570 7.02e-27 102.0 COG3160@1|root,COG3160@2|Bacteria 2|Bacteria K Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_70340_1 1049564.TevJSym_al00380 2.59e-41 164.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1J4XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_63708_1 933262.AXAM01000023_gene658 1.96e-153 468.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_30816_1 187272.Mlg_0737 2.38e-121 358.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_140961_1 95619.PM1_0229085 2.63e-29 114.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N k59_140961_2 1049564.TevJSym_aq00470 6.19e-69 211.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1J60N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iJN746.PP_5412 ATP-synt_DE,ATP-synt_DE_N k59_140961_3 1049564.TevJSym_aq00480 6.92e-92 271.0 COG1047@1|root,COG1047@2|Bacteria,1RH9C@1224|Proteobacteria,1S63R@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_115121_1 1408303.JNJJ01000092_gene2414 1.09e-31 119.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,1ZEUI@1386|Bacillus 91061|Bacilli E Cysteine synthase cysK5 - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_115121_2 335543.Sfum_2682 3.66e-73 229.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MQ77@213462|Syntrophobacterales 28221|Deltaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_11781_1 880072.Desac_1216 7.22e-139 407.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_50478_1 1322246.BN4_12596 1.99e-06 48.5 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2M7WP@213115|Desulfovibrionales 28221|Deltaproteobacteria L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_50478_2 589865.DaAHT2_0294 2.77e-22 98.6 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_147730_1 1049564.TevJSym_ag00690 3.25e-294 821.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 k59_45107_1 933262.AXAM01000017_gene3121 5.16e-70 223.0 COG0500@1|root,COG2226@2|Bacteria,1RASQ@1224|Proteobacteria,42QTY@68525|delta/epsilon subdivisions,2WMN2@28221|Deltaproteobacteria,2MJIY@213118|Desulfobacterales 28221|Deltaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_82934_1 314230.DSM3645_29936 7.96e-51 166.0 COG1943@1|root,COG1943@2|Bacteria,2J3NS@203682|Planctomycetes 203682|Planctomycetes L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_180167_1 1453501.JELR01000002_gene349 4.77e-40 152.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_160838_1 2903.EOD26895 1.32e-61 206.0 COG0152@1|root,KOG2835@2759|Eukaryota 2759|Eukaryota F phosphoribosylaminoimidazole carboxylase activity ADE2 GO:0003674,GO:0003824,GO:0004638,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009405,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044464,GO:0046040,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046390,GO:0046483,GO:0051704,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.21 ko:K11808 ko00230,ko01100,ko01110,map00230,map01100,map01110 M00048 R04209 RC00590 ko00000,ko00001,ko00002,ko01000 - - - AIRC,ATP-grasp k59_96689_2 644282.Deba_1735 0.000469 40.0 2APA5@1|root,31EC7@2|Bacteria,1RHMQ@1224|Proteobacteria,42UND@68525|delta/epsilon subdivisions,2WQK4@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_173061_1 289376.THEYE_A0432 4.97e-24 102.0 COG0263@1|root,COG0263@2|Bacteria,3J0GU@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_173061_2 264732.Moth_0561 4.72e-69 224.0 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,42F3Z@68295|Thermoanaerobacterales 186801|Clostridia S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_129039_1 1470593.BW43_05246 6.95e-153 445.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family xylC - 1.2.1.28 ko:K00141 ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220 M00537,M00538 R01293,R01419,R05289,R05663,R05664,R07667 RC00075 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_101873_2 1121378.KB899698_gene1679 7.6e-26 101.0 COG5113@1|root,COG3236@2|Bacteria 2|Bacteria O hydrolase activity, hydrolyzing N-glycosyl compounds - - - ko:K09935 - - - - ko00000 - - - DUF1768 k59_101873_3 1121382.JQKG01000001_gene2517 1.42e-37 153.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria 2|Bacteria K chromosome segregation terL - - - - - - - - - - - Terminase_6,Terminase_6C k59_101873_5 504832.OCAR_6609 3.03e-48 176.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria,3JR48@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Phage portal protein gp34 - - - - - - - - - - - Phage_portal k59_101873_6 997346.HMPREF9374_1122 4.26e-08 62.0 COG2369@1|root,COG4695@1|root,COG2369@2|Bacteria,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,4I4EN@91061|Bacilli,27C4U@186824|Thermoactinomycetaceae 91061|Bacilli S Phage portal protein - - - - - - - - - - - - Phage_portal k59_101873_7 630626.EBL_c20590 3.81e-17 87.8 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,1S089@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Prohead protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_101873_8 467481.B0VK33_9CAUD 2.28e-85 277.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098026 - - - - - - - - - - - k59_199309_1 1049564.TevJSym_am00070 1.24e-71 237.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1J5ED@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1109 Phosphomannomutase algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_199309_2 754477.Q7C_2285 2.38e-22 93.6 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,46006@72273|Thiotrichales 72273|Thiotrichales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_180458_1 765912.Thimo_0593 7.94e-56 178.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_180458_2 1049564.TevJSym_ap00550 1.12e-14 72.4 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_17765_1 1121406.JAEX01000001_gene165 4.92e-31 128.0 COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3 k59_25114_1 1129794.C427_3060 7.32e-05 51.2 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,4645X@72275|Alteromonadaceae 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_154294_1 1121405.dsmv_1666 1.05e-204 601.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_154294_2 177437.HRM2_15150 9.16e-40 143.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2MMPY@213118|Desulfobacterales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_102260_1 138119.DSY3068 2.17e-62 204.0 COG0644@1|root,COG0644@2|Bacteria,1UZT1@1239|Firmicutes,25DJ8@186801|Clostridia 186801|Clostridia C oxidoreductase cbrA - - - - - - - - - - - FAD_binding_3,Lycopene_cycl,NAD_binding_8 k59_180461_1 1121430.JMLG01000012_gene2023 3.08e-32 120.0 COG0727@1|root,COG0727@2|Bacteria,1V1RT@1239|Firmicutes,24GKT@186801|Clostridia,263XF@186807|Peptococcaceae 186801|Clostridia S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_97031_1 472759.Nhal_1221 2.34e-96 289.0 COG5424@1|root,COG5424@2|Bacteria,1NQWN@1224|Proteobacteria,1SMYT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - - - - - - - - - - - - k59_173345_1 384765.SIAM614_05823 5.71e-06 52.4 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_173345_3 765912.Thimo_0929 1.54e-42 147.0 COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,1T053@1236|Gammaproteobacteria,1WWI8@135613|Chromatiales 135613|Chromatiales P TIGRFAM cobalt ABC transporter - - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_89522_1 477184.KYC_09390 6.7e-30 113.0 COG1846@1|root,COG1846@2|Bacteria,1N7PQ@1224|Proteobacteria,2VV8Y@28216|Betaproteobacteria,3T4GQ@506|Alcaligenaceae 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_89522_2 1034943.BN1094_02030 1.24e-35 130.0 COG1335@1|root,COG1335@2|Bacteria,1REAB@1224|Proteobacteria,1S53J@1236|Gammaproteobacteria,1JC59@118969|Legionellales 118969|Legionellales Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_89522_3 1114970.PSF113_2574 1.13e-49 172.0 COG2197@1|root,COG2197@2|Bacteria,1QAMX@1224|Proteobacteria 1224|Proteobacteria K PFAM regulatory protein LuxR - - - - - - - - - - - - GerE k59_56531_1 1121100.JCM6294_1007 2.27e-62 208.0 COG1397@1|root,COG1595@1|root,COG1397@2|Bacteria,COG1595@2|Bacteria,4NN3Z@976|Bacteroidetes,2G16H@200643|Bacteroidia 976|Bacteroidetes O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_25121_2 314230.DSM3645_20937 6.21e-109 322.0 COG1011@1|root,COG1011@2|Bacteria,2IZ1C@203682|Planctomycetes 203682|Planctomycetes S cryptic haloacid dehalogenase 1 - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_25121_3 420324.KI912034_gene2609 7.94e-87 266.0 COG4977@1|root,COG4977@2|Bacteria,1QV1S@1224|Proteobacteria,2TYAD@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Cupin - - - - - - - - - - - - Cupin_6,HTH_18 k59_199328_1 439235.Dalk_5090 3.94e-49 173.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_199328_2 926692.AZYG01000064_gene1008 3.39e-06 50.8 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WAIE@53433|Halanaerobiales 186801|Clostridia C TIGRFAM glutamate synthase (NADPH), homotetrameric gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_25125_1 1123279.ATUS01000001_gene1469 2.54e-101 320.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J4C5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,Globin,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9 k59_122961_1 1158294.JOMI01000001_gene1858 4e-70 220.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_167258_1 1049564.TevJSym_aw00490 2.48e-171 483.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1J4GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the ParA family fleN - - ko:K04562 - - - - ko00000,ko02035 - - - ParA k59_167258_2 1226994.AMZB01000123_gene2849 1.07e-36 139.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1YD21@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria N SRP54-type protein, GTPase domain flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_17779_1 886377.Murru_0818 8.74e-45 166.0 COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,1HYCE@117743|Flavobacteriia 976|Bacteroidetes S Large extracellular alpha-helical protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl k59_206072_1 314345.SPV1_13312 2.7e-12 64.7 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria 1224|Proteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_206072_2 1049564.TevJSym_ar00110 3.35e-138 395.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1J4NT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_206072_3 1049564.TevJSym_ar00130 2.12e-103 338.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1J4F9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3170 Tfp pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_148077_1 1121405.dsmv_3296 2.65e-75 240.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2MIPI@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM carboxyl transferase pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_148077_2 1121405.dsmv_3295 2.81e-70 222.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MI33@213118|Desulfobacterales 28221|Deltaproteobacteria C Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_109352_1 1506583.JQJY01000001_gene524 0.000379 44.7 COG0642@1|root,COG0784@1|root,COG0840@1|root,COG1511@1|root,COG2770@1|root,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,4NH0W@976|Bacteroidetes,1IJTA@117743|Flavobacteriia,2NVJ1@237|Flavobacterium 976|Bacteroidetes T GAF domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - GAF_2,HAMP,HATPase_c,HisKA,MCPsignal,PAS_4,PAS_9,Response_reg k59_109352_2 521098.Aaci_0673 6.89e-22 97.8 COG1352@1|root,COG2201@1|root,COG4191@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4191@2|Bacteria,1TPD8@1239|Firmicutes,4HAS1@91061|Bacilli 91061|Bacilli NT Chemotaxis protein CheR - - 2.1.1.80,3.1.1.61 ko:K00575,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_3,PAS_9 k59_50843_1 270374.MELB17_00210 2.69e-108 333.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,464V8@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281 GATase_6,SIS k59_135148_1 1049564.TevJSym_ac00480 3.22e-112 337.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_129385_2 301.JNHE01000018_gene3852 7.61e-26 102.0 COG1082@1|root,COG1082@2|Bacteria,1Q3WR@1224|Proteobacteria,1S04R@1236|Gammaproteobacteria,1YD51@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_31183_2 990073.ATHU01000001_gene184 3.61e-83 256.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M6H@68525|delta/epsilon subdivisions,2YNC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S ferredoxin - - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_4 k59_31183_3 76114.ebA1013 1.79e-92 284.0 COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,2VXWB@28216|Betaproteobacteria 28216|Betaproteobacteria P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_31183_4 1167006.UWK_01205 2.64e-131 401.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_187469_1 1288826.MSNKSG1_13417 3.55e-28 108.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,464ZE@72275|Alteromonadaceae 1236|Gammaproteobacteria D ATPase involved in cell division ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_187469_2 1049564.TevJSym_aa00850 6.85e-133 387.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1J4H6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_187469_3 765910.MARPU_00790 7.73e-53 174.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_31184_1 1122951.ATUE01000005_gene1617 1.77e-75 230.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_56542_1 933262.AXAM01000048_gene2581 1.59e-53 179.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2MHQM@213118|Desulfobacterales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_38265_2 439235.Dalk_1330 2.17e-25 105.0 COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_64018_1 1415779.JOMH01000001_gene2652 1.95e-61 200.0 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,1RN84@1236|Gammaproteobacteria,1X5HM@135614|Xanthomonadales 135614|Xanthomonadales H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_199349_1 1049564.TevJSym_ad01530 8.46e-82 254.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1J5W9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_204958_2 56780.SYN_00186 1.12e-41 142.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MQKE@213462|Syntrophobacterales 28221|Deltaproteobacteria U Biopolymer transport protein ExbD/TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_204958_3 335543.Sfum_0752 7.09e-09 57.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_128142_1 1049564.TevJSym_ap00720 2.67e-207 603.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1J5E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_108035_1 1304872.JAGC01000009_gene817 1.53e-102 317.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_153166_1 118166.JH976537_gene419 1.28e-101 318.0 COG3409@1|root,COG3409@2|Bacteria,1GQNA@1117|Cyanobacteria 1117|Cyanobacteria M Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_172497_1 1499967.BAYZ01000084_gene3994 5.94e-37 138.0 COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_139994_1 335543.Sfum_3470 1.83e-88 274.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MR03@213462|Syntrophobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_30063_2 187272.Mlg_2112 8.36e-48 160.0 COG0824@1|root,COG0824@2|Bacteria,1PUGZ@1224|Proteobacteria,1TAK0@1236|Gammaproteobacteria,1X21V@135613|Chromatiales 135613|Chromatiales S Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_2 k59_23856_1 335543.Sfum_3313 2.87e-61 199.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MQEZ@213462|Syntrophobacterales 28221|Deltaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_186214_1 349520.PPE_03030 1.88e-66 225.0 COG0507@1|root,COG0507@2|Bacteria,1TQWH@1239|Firmicutes,4HF2Y@91061|Bacilli,26WBJ@186822|Paenibacillaceae 91061|Bacilli L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_95830_1 572477.Alvin_1784 3.76e-54 196.0 2DBM3@1|root,2Z9WX@2|Bacteria,1R676@1224|Proteobacteria,1S1WJ@1236|Gammaproteobacteria,1X2TK@135613|Chromatiales 135613|Chromatiales S Putative beta-barrel porin 2 - - - - - - - - - - - - - k59_95830_2 396588.Tgr7_1484 3.6e-97 299.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1WXSP@135613|Chromatiales 135613|Chromatiales G alpha beta alpha domain I - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_114289_1 933262.AXAM01000040_gene1226 1.21e-61 212.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales 28221|Deltaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_121562_1 880072.Desac_1143 8.83e-143 432.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_23860_1 1177181.T9A_02945 1.44e-27 110.0 COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,1RNEY@1236|Gammaproteobacteria,1XM33@135619|Oceanospirillales 135619|Oceanospirillales K LuxR family transcriptional regulator - - - ko:K04333,ko:K20918 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - GerE k59_30067_1 1121918.ARWE01000001_gene21 1.8e-61 203.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,43S58@69541|Desulfuromonadales 28221|Deltaproteobacteria C NQR2, RnfD, RnfE family - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_146849_1 1443113.LC20_01830 9.53e-15 79.3 COG2131@1|root,COG2131@2|Bacteria,1QDAH@1224|Proteobacteria,1RRDW@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Deoxycytidylate deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_3636_1 1089551.KE386572_gene4513 3.85e-30 119.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria,4BQQ4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_134026_2 631362.Thi970DRAFT_03250 1.56e-61 199.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_192133_1 203122.Sde_2346 1.07e-48 175.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,464W8@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_179397_1 743720.Psefu_0245 1.56e-69 233.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria,1YUXY@136845|Pseudomonas putida group 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_101001_1 857087.Metme_2403 5.33e-204 614.0 COG0642@1|root,COG0784@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_101001_2 1134912.AJTV01000015_gene304 4.42e-159 452.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,2U28A@28211|Alphaproteobacteria,36ZVT@31993|Methylocystaceae 28211|Alphaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_101001_3 580340.Tlie_0921 1.92e-26 105.0 COG0779@1|root,COG0779@2|Bacteria,3TBQ4@508458|Synergistetes 508458|Synergistetes J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_101001_4 1049564.TevJSym_ap00460 1.7e-156 452.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_146856_2 1266925.JHVX01000001_gene2679 2.42e-27 111.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,372V5@32003|Nitrosomonadales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9 k59_55560_1 102125.Xen7305DRAFT_00001700 4.06e-09 58.9 COG1621@1|root,COG3291@1|root,COG1621@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - CBM_35,CBM_6,CHU_C,DUF608,Glyco_hydr_116N,He_PIG k59_198418_2 1049564.TevJSym_bd00310 2.72e-95 285.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,1RNK9@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases asrB - - ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_75373_1 247490.KSU1_D0444 6.96e-26 107.0 COG2864@1|root,COG2864@2|Bacteria,2J253@203682|Planctomycetes 203682|Planctomycetes C formate dehydrogenase - - - - - - - - - - - - - k59_69672_1 1121438.JNJA01000002_gene3346 2.07e-54 184.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,42RA5@68525|delta/epsilon subdivisions,2WMXQ@28221|Deltaproteobacteria,2M8PQ@213115|Desulfovibrionales 28221|Deltaproteobacteria S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_192374_1 1237149.C900_05680 1.59e-23 101.0 COG3367@1|root,COG3367@2|Bacteria,4NGXN@976|Bacteroidetes,47NP1@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_192374_2 1121405.dsmv_2608 1.57e-39 141.0 COG0498@1|root,COG0498@2|Bacteria 2|Bacteria E threonine synthase activity - - 2.5.1.76,4.2.3.1 ko:K01733,ko:K15527 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,PALP k59_3887_1 1049564.TevJSym_ak00310 1.56e-110 326.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1J5CU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_44432_1 1249627.D779_0933 4.17e-13 68.6 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_128428_1 1049564.TevJSym_br00020 1.03e-205 616.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_108345_1 398767.Glov_2810 2.53e-72 241.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,43U9D@69541|Desulfuromonadales 28221|Deltaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_179657_1 880072.Desac_0501 2.35e-84 271.0 COG2202@1|root,COG2204@1|root,COG3290@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_49919_1 2340.JV46_12820 6.42e-67 211.0 COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1J6I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061603,GO:0070568,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902757,GO:1902758 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2604,iEcHS_1320.EcHS_A4080,iEcolC_1368.EcolC_4158,iLF82_1304.LF82_1370,iNRG857_1313.NRG857_19230,iSBO_1134.SBO_3869,iSbBS512_1146.SbBS512_E4329,iUMNK88_1353.UMNK88_4686,ic_1306.c4801 NTP_transf_3 k59_49919_2 713586.KB900536_gene951 1.4e-65 206.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1WY0J@135613|Chromatiales 135613|Chromatiales H molybdopterin-guanine dinucleotide biosynthesis protein mobB - - ko:K03753 - - - - ko00000 - - - MobB k59_49919_3 2340.JV46_12800 6.66e-37 137.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J533@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MobB,MoeA_C,MoeA_N k59_96101_1 933262.AXAM01000019_gene1127 6.83e-36 122.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MKYU@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM Cold-shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_128429_1 1049564.TevJSym_au00540 5.56e-50 170.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_205233_1 768710.DesyoDRAFT_1667 3.2e-73 226.0 COG0410@1|root,COG0410@2|Bacteria,1U9ET@1239|Firmicutes,249MH@186801|Clostridia,260RJ@186807|Peptococcaceae 186801|Clostridia E PFAM ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_186535_1 76114.ebA983 4.41e-20 88.2 2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,2VN2M@28216|Betaproteobacteria,2KUGB@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_147146_2 1449126.JQKL01000056_gene2267 9.73e-09 57.4 COG2204@1|root,COG2204@2|Bacteria,1V6R9@1239|Firmicutes,24P9J@186801|Clostridia,26CDF@186813|unclassified Clostridiales 186801|Clostridia T cheY-homologous receiver domain - - - ko:K02490 ko02020,ko02024,map02020,map02024 M00485 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_37215_1 554065.XP_005849861.1 1.07e-09 65.9 COG0169@1|root,KOG0692@2759|Eukaryota,37I1M@33090|Viridiplantae,34GPQ@3041|Chlorophyta 3041|Chlorophyta E Shikimate dehydrogenase substrate binding domain - - 1.1.1.25,4.2.1.10 ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I,Shikimate_DH,Shikimate_dh_N k59_108352_1 1266914.ATUK01000017_gene573 5.06e-18 87.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,MASE3,PAS,PAS_4,PAS_9 k59_114603_1 1121405.dsmv_3545 2.66e-165 473.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2MJ5F@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM Bile acid sodium symporter arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_108356_1 439235.Dalk_0560 2.15e-74 238.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales 28221|Deltaproteobacteria EH TIGRFAM acetolactate synthase, large subunit, biosynthetic type ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_16908_1 706587.Desti_3092 2.75e-91 282.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WNAS@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_140342_1 396588.Tgr7_0992 4.05e-41 150.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_140342_2 762376.AXYL_01463 6.44e-41 146.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,3T384@506|Alcaligenaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_49929_1 1499967.BAYZ01000009_gene5335 9.58e-84 262.0 COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria 2|Bacteria S Belongs to the RtcB family rtcB GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_114604_1 1121405.dsmv_3797 7.74e-85 265.0 COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria 1224|Proteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_37220_1 1232437.KL661955_gene2363 5.56e-52 176.0 28MQN@1|root,2ZAZG@2|Bacteria,1MVVQ@1224|Proteobacteria,42MMM@68525|delta/epsilon subdivisions,2WKA1@28221|Deltaproteobacteria,2MHKP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_11164_2 102125.Xen7305DRAFT_00001700 3.23e-07 53.5 COG1621@1|root,COG3291@1|root,COG1621@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - CBM_35,CBM_6,CHU_C,DUF608,Glyco_hydr_116N,He_PIG k59_30381_1 335543.Sfum_1546 5.31e-115 335.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2MQWW@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_16913_1 177437.HRM2_11310 7.02e-67 222.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MIEH@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_88709_1 472759.Nhal_3119 5.44e-109 325.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_121938_1 1049564.TevJSym_am00450 2.09e-148 431.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_69708_1 96561.Dole_2649 1.54e-69 224.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_114608_1 1121405.dsmv_0457 7.92e-138 406.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MHPE@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_24184_2 358681.BBR47_26690 1.96e-26 118.0 COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,1TPTG@1239|Firmicutes,4HB7R@91061|Bacilli,26SV3@186822|Paenibacillaceae 91061|Bacilli I Acyltransferase yvhB - - - - - - - - - - - Acyl_transf_3 k59_3918_1 1049564.TevJSym_aa02240 2.31e-43 142.0 COG3450@1|root,COG3450@2|Bacteria,1N8CD@1224|Proteobacteria,1SAR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF861) - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_88712_1 1121926.AXWO01000033_gene1302 1.31e-08 55.1 COG2329@1|root,COG2329@2|Bacteria,2GTB1@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF3291) - - - - - - - - - - - - DUF3291 k59_172_1 1279019.ARQK01000055_gene1959 4.12e-41 137.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales 135613|Chromatiales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_162228_1 525257.HMPREF0204_13442 2.82e-19 83.6 COG1917@1|root,COG1917@2|Bacteria,4NX4M@976|Bacteroidetes,1IGY5@117743|Flavobacteriia,3ZSEU@59732|Chryseobacterium 976|Bacteroidetes S Cupin domain - - - - - - - - - - - - Cupin_2 k59_155722_1 351348.Maqu_0286 5.43e-44 151.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,1SYUC@1236|Gammaproteobacteria,466DP@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_52043_3 83406.HDN1F_20890 0.000981 47.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_162229_1 1049564.TevJSym_bb00110 4.29e-209 586.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1J4ZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the citrate synthase family gltA GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_00727 Citrate_synt k59_97398_1 933262.AXAM01000009_gene1487 3.39e-29 111.0 COG0727@1|root,COG0727@2|Bacteria,1RCRP@1224|Proteobacteria,42QP5@68525|delta/epsilon subdivisions,2WMQD@28221|Deltaproteobacteria,2MJI3@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_97398_2 933262.AXAM01000009_gene1486 4.53e-38 135.0 COG1028@1|root,COG1028@2|Bacteria,1R7KW@1224|Proteobacteria,42NF5@68525|delta/epsilon subdivisions,2WM4D@28221|Deltaproteobacteria,2MIF5@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_136291_1 1123504.JQKD01000008_gene5416 1.57e-22 92.8 COG3518@1|root,COG3518@2|Bacteria,1RF51@1224|Proteobacteria,2VRQP@28216|Betaproteobacteria,4AEKX@80864|Comamonadaceae 28216|Betaproteobacteria S Gene 25-like lysozyme - - - ko:K11897 - M00334 - - ko00000,ko00002,ko02044 - - - GPW_gp25 k59_136291_2 257310.BB0805 7.02e-71 236.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,2VHXS@28216|Betaproteobacteria,3T20I@506|Alcaligenaceae 28216|Betaproteobacteria S Type VI secretion vasA - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_32574_1 1232437.KL661971_gene4888 4.02e-61 213.0 COG0067@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0070@2|Bacteria,1NZ4D@1224|Proteobacteria,43B3T@68525|delta/epsilon subdivisions,2X6HR@28221|Deltaproteobacteria,2MN6R@213118|Desulfobacterales 28221|Deltaproteobacteria E GXGXG motif - - - - - - - - - - - - GATase_6,GXGXG k59_52045_1 706587.Desti_5386 6.93e-61 197.0 COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,42TZD@68525|delta/epsilon subdivisions,2WQIE@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Phosphonate ABC transporter, periplasmic - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_52045_2 706587.Desti_5385 4.08e-112 348.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_45534_1 335543.Sfum_1699 2.31e-45 154.0 COG0250@1|root,COG0250@2|Bacteria,1QTE5@1224|Proteobacteria,42QT0@68525|delta/epsilon subdivisions,2WN4B@28221|Deltaproteobacteria,2MS5A@213462|Syntrophobacterales 28221|Deltaproteobacteria K antitermination protein NusG - - - ko:K05785 - - - - ko00000,ko03000 - - - NusG k59_52046_1 335543.Sfum_2565 6.48e-110 337.0 COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MQWJ@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit - - 2.3.1.169 ko:K14138 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R08433,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhC k59_190_2 870187.Thini_0084 1.55e-36 124.0 COG3514@1|root,COG3514@2|Bacteria,1NAV1@1224|Proteobacteria,1S9TK@1236|Gammaproteobacteria,463K8@72273|Thiotrichales 72273|Thiotrichales S CopG antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_45535_1 1499967.BAYZ01000078_gene987 3.41e-52 178.0 COG0701@1|root,COG0701@2|Bacteria,2NQ6E@2323|unclassified Bacteria 2|Bacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1,HMA k59_32579_1 1232437.KL662006_gene4348 4.34e-07 53.1 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,2MIAG@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_175152_1 941449.dsx2_1873 2.05e-64 223.0 COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2M8ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,PA,Peptidase_M28 k59_194549_1 96561.Dole_2783 1.71e-47 164.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_116872_1 335543.Sfum_0413 1.57e-70 231.0 COG0457@1|root,COG1944@1|root,COG0457@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2MRDN@213462|Syntrophobacterales 28221|Deltaproteobacteria S YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - TPR_1,TPR_16,TPR_2,TPR_8,YcaO k59_26134_1 1122951.ATUE01000007_gene661 4.87e-41 152.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,3NJGS@468|Moraxellaceae 1236|Gammaproteobacteria P Transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_84405_1 1301098.PKB_0526 2.38e-59 216.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_84405_2 1286170.RORB6_16065 1.26e-48 176.0 COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity hsdS - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_84405_3 394221.Mmar10_0164 1.55e-39 140.0 COG1637@1|root,COG3586@1|root,COG1637@2|Bacteria,COG3586@2|Bacteria,1R4TU@1224|Proteobacteria,2U1HP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - - - - - - - - - - - k59_84405_4 696747.NIES39_Q02270 3.49e-54 176.0 COG1943@1|root,COG1943@2|Bacteria,1G631@1117|Cyanobacteria,1HBZT@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_84405_5 1158165.KB898872_gene713 1.19e-92 284.0 COG4823@1|root,COG4823@2|Bacteria,1NJIX@1224|Proteobacteria,1RSPZ@1236|Gammaproteobacteria,1X0TA@135613|Chromatiales 135613|Chromatiales V Abi-like protein - - - - - - - - - - - - Abi_2 k59_84405_6 396588.Tgr7_0604 1.75e-136 408.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,1WVY8@135613|Chromatiales 135613|Chromatiales V DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_39040_1 1122197.ATWI01000012_gene711 6.68e-40 152.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_194557_1 90813.JQMT01000001_gene309 7.03e-41 147.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,461KC@72273|Thiotrichales 72273|Thiotrichales J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_123363_1 765911.Thivi_3599 1.22e-74 225.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1WYFF@135613|Chromatiales 135613|Chromatiales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_123363_2 2340.JV46_11930 6.75e-16 76.3 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1J4U9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P antiporter yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_175168_1 1122201.AUAZ01000003_gene2101 9.87e-22 93.2 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_71479_1 1266908.AQPB01000047_gene100 8.14e-142 417.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1WW8U@135613|Chromatiales 135613|Chromatiales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_78037_1 439235.Dalk_3497 3.02e-83 263.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1QW1M@1224|Proteobacteria 1224|Proteobacteria T SMART PAS domain containing protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - - k59_194559_1 765910.MARPU_15120 2.06e-122 363.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_194559_2 1049564.TevJSym_aa01660 5.69e-38 128.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1J6MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_97427_1 998088.B565_3980 2.99e-93 280.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1Y3GC@135624|Aeromonadales 135624|Aeromonadales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_201141_1 1049564.TevJSym_ay00260 9.7e-177 511.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_201141_2 1049564.TevJSym_bm00080 8.52e-132 376.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1J5NT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iECH74115_1262.ECH74115_0566,iEKO11_1354.EKO11_3373,iG2583_1286.G2583_0586,iJN746.PP_1506 ADK,ADK_lid k59_201141_3 395493.BegalDRAFT_2658 4.13e-29 106.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria,463HX@72273|Thiotrichales 72273|Thiotrichales O Thioredoxin - - - - - - - - - - - - Thioredoxin k59_195_1 768671.ThimaDRAFT_1434 1.38e-134 394.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_195_2 1049564.TevJSym_ag00440 3.28e-116 335.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1J4YR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH COG0512 Anthranilate para-aminobenzoate synthases component II pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_195_3 1049564.TevJSym_ag00400 3.78e-38 136.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_71483_1 1255043.TVNIR_1352 2.93e-125 383.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria 1236|Gammaproteobacteria T N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - AMIN k59_52056_2 1049564.TevJSym_ak00660 7.5e-85 252.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1J6C3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_155736_1 349521.HCH_03784 1e-08 61.6 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,1XH6I@135619|Oceanospirillales 135619|Oceanospirillales M Rhs family - - - - - - - - - - - - RHS,RHS_repeat,Tox-HNH-EHHH k59_90976_1 765913.ThidrDRAFT_0532 1.14e-124 362.0 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,1RMM9@1236|Gammaproteobacteria,1WY17@135613|Chromatiales 135613|Chromatiales H May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_90976_2 93220.LV28_15595 2.68e-59 194.0 COG2267@1|root,COG2267@2|Bacteria,1QUZX@1224|Proteobacteria,2VQK8@28216|Betaproteobacteria,1KIFC@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_90976_4 267608.RSp0225 1.98e-73 226.0 COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2VIZ5@28216|Betaproteobacteria,1K2IT@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.1.2.41,4.2.1.101 ko:K18383 ko00360,ko01100,ko01110,map00360,map01100,map01110 - R05772,R05773 RC00307,RC01468,RC01828 ko00000,ko00001,ko01000 - - - ECH_1 k59_110367_2 930166.CD58_14865 1.23e-25 115.0 COG1413@1|root,COG1413@2|Bacteria,1NUN2@1224|Proteobacteria,1RYE5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2 k59_168702_1 1123228.AUIH01000002_gene1502 2.92e-06 50.1 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1XJCK@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_168702_2 1049564.TevJSym_ao00650 2.97e-173 490.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1J5F5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_168702_4 1049564.TevJSym_ao00640 3.2e-91 276.0 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1S92A@1236|Gammaproteobacteria,1J7AU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DUF218 domain Z012_07930 GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564 - - - - - - - - - - DUF218 k59_168702_5 63737.Npun_R2269 7.18e-46 169.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF,HAMP,PAS_3,Zn_Tnp_IS1595,dCache_1 k59_168702_6 716928.AJQT01000077_gene962 6.34e-32 130.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_129833_1 768671.ThimaDRAFT_2367 8.44e-127 372.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales 135613|Chromatiales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_129833_2 1049564.TevJSym_ag01030 1.83e-176 508.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1J5DY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_149246_2 1219045.BV98_003429 1.76e-72 235.0 COG2207@1|root,COG2207@2|Bacteria,1MXT9@1224|Proteobacteria,2U0UP@28211|Alphaproteobacteria,2KCUE@204457|Sphingomonadales 204457|Sphingomonadales K AraC-binding-like domain - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_149246_4 702113.PP1Y_AT31786 3.85e-217 617.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2U5D5@28211|Alphaproteobacteria,2K1C7@204457|Sphingomonadales 204457|Sphingomonadales C Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process - - 1.17.99.1 ko:K05797 ko00623,ko01100,ko01120,map00623,map01100,map01120 - R02675,R11194 RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_103878_1 768671.ThimaDRAFT_0173 3.14e-87 274.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_103878_2 713586.KB900536_gene386 2.09e-05 45.8 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales 135613|Chromatiales C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_162259_4 1410620.SHLA_35c000120 2.12e-33 126.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria 1224|Proteobacteria M Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_58559_1 1122135.KB893146_gene1459 1e-46 157.0 COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,2U5DY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-transferase plsC - - - - - - - - - - - Acyltransferase k59_155743_1 234267.Acid_0256 2.32e-85 274.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,3Y2Q1@57723|Acidobacteria 2|Bacteria CJ Succinyl-CoA ligase like flavodoxin domain ferA - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_175182_1 1121405.dsmv_1256 2.59e-54 181.0 COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria,2MIJG@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS_4,PAS_9 k59_104116_2 1453501.JELR01000002_gene1205 2.39e-187 548.0 COG1404@1|root,COG5640@1|root,COG1404@2|Bacteria,COG5640@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG1404 Subtilisin-like serine proteases - GO:0005575,GO:0005576 - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PKD,PPC,P_proprotein,Peptidase_S8 k59_188419_1 983545.Glaag_2938 9.86e-25 102.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,4641X@72275|Alteromonadaceae 1236|Gammaproteobacteria C oxidase subunit 1 cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iPC815.YPO1117,iSFxv_1172.SFxv_0621,iS_1188.S0577 Cyt_bd_oxida_I k59_175433_1 519989.ECTPHS_04129 2.12e-81 254.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_175433_2 765910.MARPU_11245 9.21e-28 113.0 COG0671@1|root,COG0671@2|Bacteria,1NAJ7@1224|Proteobacteria,1SDY6@1236|Gammaproteobacteria,1WW8C@135613|Chromatiales 135613|Chromatiales I PFAM phosphoesterase PA-phosphatase related - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_175433_3 1049564.TevJSym_ab00300 3.35e-104 333.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1JBIG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_52281_1 933262.AXAM01000010_gene1377 8.29e-35 129.0 COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,42PUC@68525|delta/epsilon subdivisions,2WK0V@28221|Deltaproteobacteria,2MIWD@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_84706_1 335543.Sfum_2986 9.18e-21 92.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2MQE6@213462|Syntrophobacterales 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_104125_1 596152.DesU5LDRAFT_2417 6.33e-46 159.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WNVW@28221|Deltaproteobacteria,2MGJV@213115|Desulfovibrionales 28221|Deltaproteobacteria HP PFAM ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_104125_2 207559.Dde_3104 1.25e-35 131.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N28@68525|delta/epsilon subdivisions,2WJVR@28221|Deltaproteobacteria,2M825@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily hemU - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_91206_1 706587.Desti_5386 1.91e-73 231.0 COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,42TZD@68525|delta/epsilon subdivisions,2WQIE@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Phosphonate ABC transporter, periplasmic - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_188429_1 1049564.TevJSym_au00400 2.51e-43 162.0 COG2982@1|root,COG3420@1|root,COG2982@2|Bacteria,COG3420@2|Bacteria,1QWWH@1224|Proteobacteria 1224|Proteobacteria P Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Beta_helix,NosD,W_rich_C k59_175440_1 396588.Tgr7_1019 2.45e-210 596.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_65225_1 1304888.ATWF01000002_gene35 3.95e-65 210.0 COG0502@1|root,COG0502@2|Bacteria,2GF6Z@200930|Deferribacteres 200930|Deferribacteres H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism - - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - - k59_149563_1 631362.Thi970DRAFT_04432 9.13e-94 287.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales 135613|Chromatiales P Sodium/hydrogen exchanger family - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_65227_1 1121378.KB899729_gene4098 3.33e-34 134.0 COG4251@1|root,COG4251@2|Bacteria 2|Bacteria T photoreceptor activity - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_151920_1 225937.HP15_3367 5.6e-44 162.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,1RNY4@1236|Gammaproteobacteria,464EY@72275|Alteromonadaceae 1236|Gammaproteobacteria P alkaline phosphatase phoD - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_73745_1 177437.HRM2_14810 6.92e-103 310.0 COG0458@1|root,COG0458@2|Bacteria,1QWN2@1224|Proteobacteria,43BT0@68525|delta/epsilon subdivisions,2X73Q@28221|Deltaproteobacteria,2MMZ4@213118|Desulfobacterales 28221|Deltaproteobacteria EF ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_42147_1 1049564.TevJSym_aw00210 4.44e-160 456.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM sulfite reductase, dissimilatory-type alpha subunit dsrA - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_164682_1 1121405.dsmv_3118 4.06e-93 289.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MID@68525|delta/epsilon subdivisions,2WJYT@28221|Deltaproteobacteria,2MISG@213118|Desulfobacterales 28221|Deltaproteobacteria EK PFAM aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2,GntR k59_158290_2 580332.Slit_2127 1.98e-83 249.0 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VQ1S@28216|Betaproteobacteria 28216|Betaproteobacteria K PFAM regulatory protein AsnC Lrp family - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 k59_2356_1 396588.Tgr7_3086 2.3e-63 197.0 COG0864@1|root,COG0864@2|Bacteria,1RDN6@1224|Proteobacteria,1S85W@1236|Gammaproteobacteria,1X274@135613|Chromatiales 135613|Chromatiales K NikR C terminal nickel binding domain - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_2356_2 272630.MexAM1_META1p4098 1.48e-23 98.6 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,1JSJQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_203679_2 765914.ThisiDRAFT_2673 2.46e-49 174.0 COG3335@1|root,COG3335@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales 135613|Chromatiales L PFAM Integrase core domain - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_33 k59_203679_3 1121479.AUBS01000002_gene3633 3.63e-53 209.0 COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD k59_203679_4 765914.ThisiDRAFT_0250 7.89e-125 383.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_138599_1 177437.HRM2_37290 1.13e-49 177.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,42N04@68525|delta/epsilon subdivisions,2WJS0@28221|Deltaproteobacteria,2MHWU@213118|Desulfobacterales 28221|Deltaproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_80742_1 1249627.D779_3193 5.81e-175 520.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_73749_1 880072.Desac_1255 2.6e-79 254.0 COG0457@1|root,COG1944@1|root,COG0457@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2MRDN@213462|Syntrophobacterales 28221|Deltaproteobacteria S YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - TPR_1,TPR_16,TPR_2,TPR_8,YcaO k59_42153_1 1523503.JPMY01000010_gene2524 2.26e-12 67.4 COG0388@1|root,COG0388@2|Bacteria,1MXBR@1224|Proteobacteria,1RQ4Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolase yafV GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050152,GO:0071944,GO:0106008 3.5.1.3 ko:K11206,ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_112990_1 1049564.TevJSym_am00390 0.0 1046.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J5C9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_106371_1 706587.Desti_2952 6.13e-70 230.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2MR0I@213462|Syntrophobacterales 28221|Deltaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_99644_1 156889.Mmc1_2503 1.28e-35 133.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_126364_1 1249627.D779_1001 9.39e-25 106.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWES@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_126364_2 1121448.DGI_2662 1.45e-34 138.0 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2 k59_35322_1 1049564.TevJSym_ab02000 1.09e-202 587.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RQRW@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the V-ATPase 116 kDa subunit family atpI - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_28666_1 1109445.AGSX01000125_gene2462 2.94e-90 288.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1Z0GI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Belongs to the 5'-nucleotidase family yhcR - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_132724_1 596154.Alide2_2046 4.84e-130 376.0 COG2958@1|root,COG2958@2|Bacteria,1R6W9@1224|Proteobacteria,2VHAH@28216|Betaproteobacteria,4AD0N@80864|Comamonadaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - ko:K09805 - - - - ko00000 - - - - k59_93971_1 287986.DV20_10700 1.01e-08 58.2 COG3293@1|root,COG3293@2|Bacteria,2IKID@201174|Actinobacteria,4E6S6@85010|Pseudonocardiales 201174|Actinobacteria L Putative transposase of IS4/5 family (DUF4096) - - - ko:K07492 - - - - ko00000 - - - DUF4096 k59_15386_1 595460.RRSWK_03637 1.51e-85 265.0 COG3328@1|root,COG3328@2|Bacteria,2J0T4@203682|Planctomycetes 203682|Planctomycetes L COG3328 Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_22569_1 395493.BegalDRAFT_3062 2.86e-06 49.3 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU pilus assembly protein PilW pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_178146_1 596151.DesfrDRAFT_1082 2.59e-46 159.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2M9HU@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_178146_2 1304885.AUEY01000001_gene3191 1.07e-64 217.0 COG0484@1|root,COG0484@2|Bacteria,1R72H@1224|Proteobacteria,42NCE@68525|delta/epsilon subdivisions,2WKDN@28221|Deltaproteobacteria,2MKP5@213118|Desulfobacterales 28221|Deltaproteobacteria O Class III cytochrome C family - - - - - - - - - - - - Cytochrom_CIII k59_138748_1 1297742.A176_04138 5.61e-08 56.2 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WP5J@28221|Deltaproteobacteria,2Z2XG@29|Myxococcales 28221|Deltaproteobacteria H B12 binding domain metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_138748_2 1304880.JAGB01000002_gene1910 2.28e-54 177.0 COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia 186801|Clostridia S TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2 k59_132865_1 679201.HMPREF9334_00252 1.22e-09 59.7 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H2BF@909932|Negativicutes 909932|Negativicutes S Competence protein ComEC comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_28791_2 1231185.BAMP01000081_gene3657 5.54e-37 129.0 COG2329@1|root,COG2329@2|Bacteria,1RGVV@1224|Proteobacteria,2U9A3@28211|Alphaproteobacteria,43KD2@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Involved in biosynthesis of extracellular polysaccharides MA20_35560 - - - - - - - - - - - ABM k59_164845_1 765910.MARPU_06210 1.12e-179 508.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales 135613|Chromatiales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_164845_2 1266909.AUAG01000007_gene2330 9.33e-118 351.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1WWYX@135613|Chromatiales 135613|Chromatiales E TIGRFAM lysine 2,3-aminomutase YodO family protein - - 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - - Fer4_12,Fer4_14,Radical_SAM k59_191033_1 335543.Sfum_2709 3.36e-140 414.0 COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria,2MR85@213462|Syntrophobacterales 28221|Deltaproteobacteria H Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_152032_1 156889.Mmc1_0241 3.8e-41 148.0 COG2172@1|root,COG3437@1|root,COG2172@2|Bacteria,COG3437@2|Bacteria,1QWD9@1224|Proteobacteria,2TWV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2,Response_reg k59_48291_1 1049564.TevJSym_bi00100 3.1e-106 319.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1J56U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 AA_kinase,Acetyltransf_1 k59_48291_2 1049564.TevJSym_bi00120 9.93e-149 429.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1J5CF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily argE GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0008777,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_4488 M20_dimer,Peptidase_M20,Peptidase_M28 k59_35507_1 1408433.JHXV01000044_gene3190 4.7e-22 95.1 COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,1HX04@117743|Flavobacteriia,2PA4I@246874|Cryomorphaceae 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_35507_3 640081.Dsui_1801 1.35e-44 155.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VPQ9@28216|Betaproteobacteria,2M01K@206389|Rhodocyclales 206389|Rhodocyclales D ATPase MipZ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - CbiA k59_35507_4 570967.JMLV01000007_gene891 2.97e-131 389.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2JPZX@204441|Rhodospirillales 204441|Rhodospirillales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_28796_1 765912.Thimo_0972 8.06e-66 207.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales 135613|Chromatiales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_178157_1 1278307.KB907006_gene222 7.07e-64 211.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - ko:K02841,ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_15391_1 1336233.JAEH01000040_gene4289 2.15e-63 207.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2Q9DZ@267890|Shewanellaceae 1236|Gammaproteobacteria T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_54537_1 472759.Nhal_3579 3.86e-41 138.0 2BC31@1|root,325MS@2|Bacteria,1NBYV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_54537_2 90813.JQMT01000001_gene181 2.79e-24 97.1 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,460YJ@72273|Thiotrichales 72273|Thiotrichales G HAD-hyrolase-like gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_132873_1 1123500.ATUU01000003_gene1208 1.16e-13 75.1 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,4HAMF@91061|Bacilli,4AXBT@81850|Leuconostocaceae 91061|Bacilli J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_158499_1 748247.AZKH_0641 0.000398 42.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VKXU@28216|Betaproteobacteria,2KVSV@206389|Rhodocyclales 206389|Rhodocyclales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_158499_2 1265505.ATUG01000003_gene627 1.16e-34 123.0 2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42TGA@68525|delta/epsilon subdivisions,2WQAG@28221|Deltaproteobacteria,2MKHK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_42312_1 883096.HMPREF9699_01749 1.31e-59 205.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 k59_42312_2 391615.ABSJ01000007_gene672 4.94e-162 462.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein fnlA - 5.1.3.2 ko:K17716 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00362 R00291 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Polysacc_syn_2C,Polysacc_synt_2 k59_42312_3 1177181.T9A_01670 1.02e-149 434.0 COG0451@1|root,COG1898@1|root,COG0451@2|Bacteria,COG1898@2|Bacteria,1MXGB@1224|Proteobacteria,1RSK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM COG0451 Nucleoside-diphosphate-sugar epimerases fnlB - 1.1.1.367 ko:K19068 - - - - ko00000,ko01000 - - - Epimerase k59_42312_4 1177181.T9A_01671 7.11e-219 610.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1RPNC@1236|Gammaproteobacteria,1XRP8@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - - - - - - - - - - - Epimerase_2 k59_42312_5 1397527.Q670_12965 5.35e-140 412.0 COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,1RS9J@1236|Gammaproteobacteria,1XM49@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1 k59_42312_6 102232.GLO73106DRAFT_00028990 2.35e-41 151.0 COG4714@1|root,COG4714@2|Bacteria,1G43S@1117|Cyanobacteria 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_42312_7 1111732.AZOD01000028_gene779 2.41e-86 259.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1SYQJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Sugar transferase - - - ko:K13012 - - - - ko00000,ko01005 - - - Bac_transf k59_42312_8 1111732.AZOD01000028_gene780 4.86e-204 573.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1X3NN@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_42312_9 1049564.TevJSym_at00310 6.77e-289 808.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RYF4@1236|Gammaproteobacteria,1J8MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_2 k59_145671_2 1049564.TevJSym_as00140 4.9e-97 295.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_61387_1 1220534.B655_1415 2.04e-50 177.0 arCOG02348@1|root,arCOG02348@2157|Archaea,2Y7T3@28890|Euryarchaeota 28890|Euryarchaeota T Histidine kinase - - - - - - - - - - - - HATPase_c k59_120023_4 1121035.AUCH01000002_gene1534 5.52e-126 362.0 COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2VHB7@28216|Betaproteobacteria 28216|Betaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_120023_5 43354.JOIJ01000003_gene3838 1.47e-35 129.0 2DKP5@1|root,32UFC@2|Bacteria,2H28I@201174|Actinobacteria,4E5NA@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - DUF2867,Polyketide_cyc2 k59_120023_6 1449976.KALB_2853 3.96e-37 139.0 COG0819@1|root,COG0819@2|Bacteria,2I9CY@201174|Actinobacteria,4E40C@85010|Pseudonocardiales 201174|Actinobacteria K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway - - - - - - - - - - - - TENA_THI-4 k59_120023_7 1535422.ND16A_0640 9.11e-12 63.2 2C073@1|root,34CEX@2|Bacteria,1PAED@1224|Proteobacteria,1SVHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_152037_1 1121405.dsmv_0466 4.74e-44 150.0 COG4970@1|root,COG4970@2|Bacteria,1NAVW@1224|Proteobacteria,42V4H@68525|delta/epsilon subdivisions,2WRE8@28221|Deltaproteobacteria,2MM4W@213118|Desulfobacterales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02457 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_152037_2 1304872.JAGC01000009_gene586 1.24e-12 64.7 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MBZA@213115|Desulfovibrionales 28221|Deltaproteobacteria U PFAM type II secretion system protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_138770_1 398527.Bphyt_2061 1.66e-20 85.5 COG4274@1|root,COG4274@2|Bacteria,1MZVV@1224|Proteobacteria,2VUPM@28216|Betaproteobacteria,1K8BT@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM GYD family protein - - - - - - - - - - - - GYD k59_87199_1 335543.Sfum_1181 3.3e-90 280.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_48301_1 1123371.ATXH01000011_gene60 1.43e-45 161.0 COG3852@1|root,COG3852@2|Bacteria,2GI9Z@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_61393_1 485913.Krac_12092 8.07e-79 251.0 COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi 200795|Chloroflexi I PFAM carboxyl transferase - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_164860_1 755731.Clo1100_2264 2.49e-30 123.0 COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36E1G@31979|Clostridiaceae 186801|Clostridia E Belongs to the peptidase M24B family pepP - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_145678_1 204773.HEAR1352 5.55e-10 59.3 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,4736M@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_145678_2 1026882.MAMP_02686 5.52e-22 95.5 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,460FM@72273|Thiotrichales 72273|Thiotrichales S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_122800_1 857087.Metme_1124 6.34e-124 400.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_56409_1 1250232.JQNJ01000001_gene2908 2.19e-61 206.0 COG3299@1|root,COG3299@2|Bacteria 2|Bacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_56409_3 756280.R9ZYL9_9CAUD 9.45e-20 87.8 4QGE5@10239|Viruses,4QW4H@35237|dsDNA viruses no RNA stage,4QQMI@28883|Caudovirales,4QJ3T@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_76130_1 716928.AJQT01000067_gene3877 2.81e-15 78.6 COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,2VGDP@28211|Alphaproteobacteria,4BA91@82115|Rhizobiaceae 28211|Alphaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - k59_199211_1 1123371.ATXH01000008_gene209 1.16e-18 87.4 COG2864@1|root,COG2864@2|Bacteria,2GHPY@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_205906_1 1392493.JIAB01000001_gene1228 1.32e-42 157.0 COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,27J6H@186928|unclassified Lachnospiraceae 186801|Clostridia P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_134977_1 1121937.AUHJ01000010_gene1706 1.52e-100 322.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,464PM@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG1404 Subtilisin-like serine proteases bprV - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PKD,Peptidase_S8 k59_38077_1 1163617.SCD_n00988 1.3e-103 309.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2VPZ0@28216|Betaproteobacteria 28216|Betaproteobacteria G deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_205907_2 1396141.BATP01000007_gene5760 6.82e-40 145.0 COG3637@1|root,COG3637@2|Bacteria,46W5R@74201|Verrucomicrobia,2IU7G@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_193013_1 1049564.TevJSym_ac01380 2.3e-65 204.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SASG@1236|Gammaproteobacteria,1JB8P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_96873_2 1122135.KB893157_gene355 2.88e-35 126.0 COG0457@1|root,COG0457@2|Bacteria,1N6TJ@1224|Proteobacteria,2UG5W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_12,TPR_16,TPR_19,TPR_2 k59_147948_1 983545.Glaag_0929 1.03e-51 187.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,465BB@72275|Alteromonadaceae 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_102103_1 1265505.ATUG01000002_gene1770 2.28e-24 96.3 COG1908@1|root,COG1908@2|Bacteria,1NYK9@1224|Proteobacteria,430KP@68525|delta/epsilon subdivisions,2WW0D@28221|Deltaproteobacteria,2MNPR@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_134985_1 1157490.EL26_09215 2.24e-24 104.0 COG3852@1|root,COG3852@2|Bacteria,1UWRJ@1239|Firmicutes,4I2N7@91061|Bacilli,279GQ@186823|Alicyclobacillaceae 91061|Bacilli T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS k59_56417_2 1219080.VEZ01S_17_00370 5.86e-124 367.0 2EYAZ@1|root,33RJC@2|Bacteria,1NIM9@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_89408_1 1049564.TevJSym_ag01010 0.0 932.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction Histidine kinase ntrY - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8 k59_89408_2 1049564.TevJSym_ag01020 3.8e-42 144.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_122819_1 96561.Dole_3250 8.62e-166 479.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_141221_1 395493.BegalDRAFT_0992 8.54e-29 120.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1T24Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase, GGDEF domain - - 2.7.7.65 ko:K20954 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_160968_1 981383.AEWH01000041_gene3598 2.88e-08 55.8 COG0745@1|root,COG0745@2|Bacteria,1TRK5@1239|Firmicutes,4HE4N@91061|Bacilli 91061|Bacilli T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ycbL - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_193023_1 318167.Sfri_1239 1.34e-85 281.0 COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_167155_1 1121403.AUCV01000054_gene2598 4.44e-28 107.0 COG2220@1|root,COG2220@2|Bacteria,1PFZZ@1224|Proteobacteria,42SXY@68525|delta/epsilon subdivisions,2WPFM@28221|Deltaproteobacteria,2MMG4@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_167155_2 880072.Desac_2873 6.93e-16 76.6 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MQVT@213462|Syntrophobacterales 28221|Deltaproteobacteria O DnaJ molecular chaperone homology domain - - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_56426_1 335543.Sfum_1954 4.72e-89 283.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria,2MR73@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM NADH-quinone oxidoreductase, chain G nuoG-2 - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_187328_1 1121405.dsmv_3780 4.39e-98 296.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_115343_1 631362.Thi970DRAFT_03644 5.04e-157 458.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_115343_2 580332.Slit_0857 7.5e-05 44.7 COG4191@1|root,COG4191@2|Bacteria,1MXRR@1224|Proteobacteria,2VN7B@28216|Betaproteobacteria 28216|Betaproteobacteria T PAS PAC sensor signal transduction histidine kinase - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HATPase_c,PAS k59_160974_1 880072.Desac_0829 1.45e-33 128.0 COG0527@1|root,COG0527@2|Bacteria,1NAE6@1224|Proteobacteria,42VF1@68525|delta/epsilon subdivisions,2WSF3@28221|Deltaproteobacteria 28221|Deltaproteobacteria E aspartate kinase activity - - - - - - - - - - - - - k59_56435_1 2340.JV46_02810 3.52e-78 244.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_160981_1 439235.Dalk_3288 1.76e-175 522.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MIFX@213118|Desulfobacterales 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_76166_1 338963.Pcar_1612 6.48e-60 206.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,43S2H@69541|Desulfuromonadales 28221|Deltaproteobacteria EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_70652_1 1249627.D779_0973 3.88e-68 212.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1WY3H@135613|Chromatiales 135613|Chromatiales L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_199228_1 323261.Noc_0717 1.35e-53 180.0 COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1WXGI@135613|Chromatiales 135613|Chromatiales M PFAM ErfK YbiS YcfS YnhG family protein - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - SPOR,YkuD k59_205921_1 1026882.MAMP_00938 4.02e-41 140.0 COG2995@1|root,COG2995@2|Bacteria,1NA1F@1224|Proteobacteria,1SERF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Paraquat-inducible protein A - - - - - - - - - - - - PqiA k59_205921_2 472759.Nhal_1941 9.42e-271 771.0 COG1203@1|root,COG1713@1|root,COG1203@2|Bacteria,COG1713@2|Bacteria,1MX7A@1224|Proteobacteria,1RQBR@1236|Gammaproteobacteria,1WXK6@135613|Chromatiales 135613|Chromatiales L helicase Cas3 - - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD k59_205921_3 870187.Thini_1149 2.94e-104 307.0 2DBAF@1|root,2Z82V@2|Bacteria,1MWRM@1224|Proteobacteria,1RWB1@1236|Gammaproteobacteria,462J9@72273|Thiotrichales 72273|Thiotrichales S CRISPR-associated protein (Cas_Cas5) - - - - - - - - - - - - Cas_Cas5d k59_205921_4 555778.Hneap_0824 7.15e-214 613.0 28HN3@1|root,2Z7WH@2|Bacteria,1MWH8@1224|Proteobacteria,1RYMP@1236|Gammaproteobacteria,1WXH2@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - ko:K19117 - - - - ko00000,ko02048 - - - Cas_Csd1 k59_205921_5 987059.RBXJA2T_07723 1.44e-139 400.0 COG3649@1|root,COG3649@2|Bacteria,1MV2A@1224|Proteobacteria,2VK51@28216|Betaproteobacteria,1KN6J@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Pfam:DUF694 - - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 k59_50699_1 1163409.UUA_00660 2.97e-19 87.8 COG4970@1|root,COG4970@2|Bacteria,1Q92Z@1224|Proteobacteria,1SEPV@1236|Gammaproteobacteria,1X7Z2@135614|Xanthomonadales 135614|Xanthomonadales NU COG4970 Tfp pilus assembly protein FimT - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_160983_1 1122201.AUAZ01000004_gene3399 9.01e-86 258.0 2DURB@1|root,32UXN@2|Bacteria,1N0HD@1224|Proteobacteria,1S3KR@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_24985_1 999611.KI421504_gene1540 4.91e-42 140.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,281TR@191028|Leisingera 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_24985_2 1238182.C882_1324 9.77e-18 80.5 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2JWES@204441|Rhodospirillales 204441|Rhodospirillales L leucine-zipper of insertion element IS481 - - - - - - - - - - - - HTH_32 k59_187615_1 1049564.TevJSym_av00010 7.14e-69 223.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1J5GB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_173501_1 880072.Desac_1006 2.24e-63 204.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,43AWM@68525|delta/epsilon subdivisions,2X6AU@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_135305_1 1122194.AUHU01000011_gene1665 7.66e-12 65.5 COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,1T32S@1236|Gammaproteobacteria,465Q0@72275|Alteromonadaceae 1236|Gammaproteobacteria O protein conserved in bacteria - - - - - - - - - - - - TPR_16,TPR_6,TPR_8,YfiO k59_135305_2 1042377.AFPJ01000028_gene2164 1.71e-32 123.0 COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,1SEZN@1236|Gammaproteobacteria,4683W@72275|Alteromonadaceae 1236|Gammaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_1,TPR_10,TPR_12,TPR_16,TPR_2,TPR_6,TPR_8 k59_4818_1 177437.HRM2_00660 8.92e-187 554.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,2MN0V@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_109473_1 69328.PVLB_09020 1.07e-40 142.0 COG3793@1|root,COG3793@2|Bacteria,1MZYH@1224|Proteobacteria,1SUJQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM Mo-dependent nitrogenase - - - ko:K05793 - - - - ko00000 - - - TerB k59_199539_1 1247726.MIM_c06910 1.38e-48 177.0 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,2W93G@28216|Betaproteobacteria,3T6FG@506|Alcaligenaceae 28216|Betaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_70863_1 909663.KI867150_gene2362 2.61e-35 124.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MRP5@213462|Syntrophobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_70863_2 909663.KI867150_gene2361 3.11e-28 105.0 COG2391@1|root,COG2391@2|Bacteria,1RDQK@1224|Proteobacteria,42RU6@68525|delta/epsilon subdivisions,2WNJT@28221|Deltaproteobacteria,2MS1R@213462|Syntrophobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_161291_1 1121405.dsmv_2241 1.26e-183 523.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MHXY@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 k59_148234_1 616991.JPOO01000001_gene3959 4.15e-91 276.0 COG1064@1|root,COG1064@2|Bacteria,4NFGP@976|Bacteroidetes,1HXI9@117743|Flavobacteriia,23HP7@178469|Arenibacter 976|Bacteroidetes S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K12957,ko:K13953,ko:K13979 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_64180_1 1121456.ATVA01000017_gene253 6.61e-44 162.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2M8EC@213115|Desulfovibrionales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_89694_1 498211.CJA_3107 8.25e-06 52.8 COG2730@1|root,COG3533@1|root,COG2730@2|Bacteria,COG3533@2|Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Big_2,Big_4,CBM_35,CHB_HEX_C_1,Cellulase,Dockerin_1,F5_F8_type_C,GH97_C,GH97_N,Glyco_hydro_43,Glyco_hydro_97,Laminin_G_3 k59_180669_1 1122135.KB893134_gene3893 1.43e-08 61.6 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase envZ - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_129563_1 1123035.ARLA01000027_gene510 1.29e-10 63.9 COG0412@1|root,COG0412@2|Bacteria,4NKMA@976|Bacteroidetes,1I0KZ@117743|Flavobacteriia,4C4BJ@83612|Psychroflexus 976|Bacteroidetes Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_129563_2 933262.AXAM01000033_gene1626 4.22e-05 44.7 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2MJ22@213118|Desulfobacterales 28221|Deltaproteobacteria F Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_123136_1 933262.AXAM01000036_gene2181 2.87e-61 213.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MI3P@213118|Desulfobacterales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_70881_1 439235.Dalk_1416 8.09e-53 177.0 COG5653@1|root,COG5653@2|Bacteria,1MV00@1224|Proteobacteria,42PW5@68525|delta/epsilon subdivisions,2WKPE@28221|Deltaproteobacteria,2MIEF@213118|Desulfobacterales 28221|Deltaproteobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_70881_2 177437.HRM2_10510 1.1e-05 47.4 COG2232@1|root,COG2232@2|Bacteria 2|Bacteria V ATP-grasp domain - - - ko:K16181 ko00300,ko01120,map00300,map01120 - R10011 RC00096,RC00141 ko00000,ko00001 - - - ATP-grasp_3,ATP-grasp_4 k59_187637_1 1049564.TevJSym_am00070 2.63e-173 516.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1J5ED@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1109 Phosphomannomutase algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_206176_1 1454004.AW11_03865 3.3e-71 232.0 COG2433@1|root,COG2433@2|Bacteria,1QUPW@1224|Proteobacteria,2VMWY@28216|Betaproteobacteria 28216|Betaproteobacteria S Bacterial conjugation TrbI-like protein traB - - ko:K12065 - - - - ko00000,ko02044 3.A.7.11.1 - - TrbI k59_206176_2 1218076.BAYB01000042_gene5694 2.41e-16 85.1 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VJIB@28216|Betaproteobacteria,1K82K@119060|Burkholderiaceae 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_206176_4 1158165.KB898873_gene372 1.24e-237 694.0 COG3451@1|root,COG3451@2|Bacteria,1MUEN@1224|Proteobacteria,1RMMX@1236|Gammaproteobacteria,1WXA7@135613|Chromatiales 135613|Chromatiales U TIGRFAM type-IV secretion system protein TraC - - - ko:K12063 - - - - ko00000,ko02044 3.A.7.11.1 - - AAA_10,TraC_F_IV k59_206176_6 498211.CJA_2583 5.7e-05 50.4 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1FG7A@10|Cellvibrio 1236|Gammaproteobacteria U Signal peptidase, peptidase S26 lepB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_206176_7 395494.Galf_0943 7.32e-33 124.0 2CGUX@1|root,31QWG@2|Bacteria,1N1MK@1224|Proteobacteria,2VN6I@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM Type-F conjugative transfer system protein TraW - - - ko:K12061 - - - - ko00000,ko02044 3.A.7.11.1 - - TraW_N k59_206176_8 983920.Y88_1373 3.07e-72 233.0 28HGF@1|root,2Z7SA@2|Bacteria,1MXUA@1224|Proteobacteria,2U2HG@28211|Alphaproteobacteria,2K2IX@204457|Sphingomonadales 204457|Sphingomonadales S Conjugal transfer protein - - - ko:K12060 - - - - ko00000,ko02044 3.A.7.11.1 - - TraU k59_206176_9 1268635.Loa_50p0020 0.000879 46.6 29PHP@1|root,30AFU@2|Bacteria,1RECD@1224|Proteobacteria,1S4EC@1236|Gammaproteobacteria,1JEUI@118969|Legionellales 118969|Legionellales S Type-F conjugative transfer system pilin assembly protein - - - ko:K12059 - - - - ko00000,ko02044 3.A.7.11.1 - - TrbC_Ftype k59_131419_3 76114.ebA6539 6.88e-07 51.6 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2VTZU@28216|Betaproteobacteria,2KWXS@206389|Rhodocyclales 206389|Rhodocyclales J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_14287_1 1122604.JONR01000007_gene2812 1.8e-55 197.0 COG0841@1|root,COG0841@2|Bacteria,1QXYC@1224|Proteobacteria,1T3KA@1236|Gammaproteobacteria,1XDE0@135614|Xanthomonadales 135614|Xanthomonadales V MMPL family - - - - - - - - - - - - MMPL k59_157115_1 530564.Psta_0173 7.64e-42 152.0 COG0501@1|root,COG3170@1|root,COG0501@2|Bacteria,COG3170@2|Bacteria,2IXM0@203682|Planctomycetes 203682|Planctomycetes O Zn-dependent protease with chaperone function - - - - - - - - - - - - Peptidase_M48 k59_150813_2 880071.Fleli_2226 2.17e-55 188.0 COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,47MCJ@768503|Cytophagia 976|Bacteroidetes H PFAM C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558,ko:K17398 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_150813_3 500637.PROVRUST_07448 2.73e-25 112.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,3Z7NF@586|Providencia 1236|Gammaproteobacteria KL Helicase C-terminal domain protein yejH GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042221,GO:0042493,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051301,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K19789 - - - - ko00000,ko03400 - - - Helicase_C,ResIII k59_170354_1 1122599.AUGR01000008_gene2500 8.62e-12 63.2 COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,1S5YE@1236|Gammaproteobacteria,1XJY8@135619|Oceanospirillales 135619|Oceanospirillales N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliN - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_170354_2 1049564.TevJSym_aw00580 1.56e-76 239.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1J4Q8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_72780_1 1049564.TevJSym_br00020 2.46e-109 350.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_46930_1 1049564.TevJSym_aa01290 6.39e-152 435.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1J5BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_92417_1 1121405.dsmv_3244 1.54e-40 145.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MINV@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_92417_2 1121405.dsmv_3243 1.31e-97 288.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,42Q82@68525|delta/epsilon subdivisions,2WMBU@28221|Deltaproteobacteria,2MI8W@213118|Desulfobacterales 28221|Deltaproteobacteria E phosphoserine phosphatase homoserine phosphotransferase bifunctional protein - - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD k59_189684_3 395493.BegalDRAFT_1208 2.23e-117 361.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,461PB@72273|Thiotrichales 72273|Thiotrichales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9 k59_53360_1 335543.Sfum_1925 1.38e-35 139.0 COG0699@1|root,COG0699@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MRED@213462|Syntrophobacterales 28221|Deltaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_40609_2 754477.Q7C_2487 0.0 1122.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4605A@72273|Thiotrichales 72273|Thiotrichales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_40609_3 488538.SAR116_1471 4.58e-83 259.0 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_40609_4 1419583.V466_10950 2.38e-90 279.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1YPQZ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria C 4Fe-4S dicluster domain glcF GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055,iJN746.PP_3747 CCG,Fer4_7,Fer4_8 k59_124893_1 398767.Glov_3421 1.83e-51 172.0 COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions,2X706@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg,sCache_2 k59_111822_4 626887.J057_16730 1.71e-76 244.0 2BWPY@1|root,2Z8BI@2|Bacteria,1QHHB@1224|Proteobacteria,1RP8D@1236|Gammaproteobacteria,4657P@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_195707_1 667014.Thein_0138 1.81e-45 156.0 COG1309@1|root,COG1309@2|Bacteria,2GIHE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Domain of unknown function (DUF1956) - - - - - - - - - - - - DUF1956,TetR_N k59_66293_1 748247.AZKH_3801 2.58e-32 125.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,2VNZ5@28216|Betaproteobacteria,2KVKW@206389|Rhodocyclales 206389|Rhodocyclales C Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_66293_2 156889.Mmc1_2503 4.38e-66 215.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1369_1 933262.AXAM01000002_gene529 2.04e-17 82.8 COG2812@1|root,COG2812@2|Bacteria,1QVB3@1224|Proteobacteria,42SBC@68525|delta/epsilon subdivisions,2WPCK@28221|Deltaproteobacteria,2MKCG@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM DNA polymerase III, delta holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_118446_1 396588.Tgr7_0755 3.2e-102 309.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales 135613|Chromatiales C PFAM FAD linked oxidase domain protein - - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_131429_1 690850.Desaf_2821 5.16e-37 128.0 COG0726@1|root,COG0726@2|Bacteria,1RH3I@1224|Proteobacteria,42T75@68525|delta/epsilon subdivisions,2WPC1@28221|Deltaproteobacteria,2MEZ8@213115|Desulfovibrionales 28221|Deltaproteobacteria G Archaea-specific editing domain of threonyl-tRNA synthetase - - - - - - - - - - - - tRNA-Thr_ED k59_131429_3 706587.Desti_5305 5.75e-100 300.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WNGS@28221|Deltaproteobacteria,2MRXP@213462|Syntrophobacterales 28221|Deltaproteobacteria S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 k59_27528_1 1218076.BAYB01000077_gene6451 1.08e-62 200.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VKCG@28216|Betaproteobacteria,1KH23@119060|Burkholderiaceae 28216|Betaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_137673_1 1279017.AQYJ01000029_gene3960 4.11e-129 395.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_60165_1 96561.Dole_2224 2.04e-105 311.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MHSN@213118|Desulfobacterales 28221|Deltaproteobacteria S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_151025_1 880072.Desac_0373 5.04e-54 191.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MQAY@213462|Syntrophobacterales 28221|Deltaproteobacteria J tRNA nucleotidyltransferase poly(A) polymerase ccaA - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_105392_1 953739.SVEN_2926 1.4e-15 82.8 COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria 201174|Actinobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_34247_1 1380347.JNII01000006_gene1402 4.3e-61 198.0 COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria,4EUV8@85013|Frankiales 201174|Actinobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - 2.1.1.288 ko:K15942 ko01057,ko01130,map01057,map01130 M00781 R06675,R06680 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_25,Methyltransf_31 k59_34247_2 1121918.ARWE01000001_gene3563 3.52e-124 364.0 COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,43AY5@68525|delta/epsilon subdivisions,2X6CI@28221|Deltaproteobacteria 28221|Deltaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_34247_3 1469607.KK073769_gene5315 2.03e-06 50.4 COG3161@1|root,COG3161@2|Bacteria,1G5KJ@1117|Cyanobacteria 1117|Cyanobacteria H Protein of unknown function (DUF98) - - 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - - DUF98 k59_34247_4 717774.Marme_4093 5.18e-81 256.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RY92@1236|Gammaproteobacteria,1XP3P@135619|Oceanospirillales 135619|Oceanospirillales C FAD-NAD(P)-binding - - 1.14.13.8 ko:K00485 ko00982,ko01120,map00982,map01120 - R08266 RC02233 ko00000,ko00001,ko01000 - - - FMO-like k59_137674_1 998674.ATTE01000001_gene3217 6.63e-24 98.6 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1S32J@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family paaF - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_131663_3 1552758.NC00_02660 1.5e-40 145.0 2BCNC@1|root,3268I@2|Bacteria,1NETW@1224|Proteobacteria,1SJ83@1236|Gammaproteobacteria,1X7GJ@135614|Xanthomonadales 135614|Xanthomonadales I Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme- A to the apo- acyl-carrier-protein of the malonate decarboxylase to yield holo- acyl-carrier-protein mdcG - 2.7.7.66 ko:K13934 - - R10706 - ko00000,ko01000 - - - MdcG k59_131663_5 1220582.RRU01S_30_00570 8.29e-66 215.0 COG0331@1|root,COG0331@2|Bacteria,1PPIC@1224|Proteobacteria,2U30P@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl transferase domain - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_170575_1 396588.Tgr7_0061 9.75e-96 296.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_112054_1 1049564.TevJSym_ad01660 4.29e-165 481.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_72997_1 2340.JV46_07980 8.06e-58 190.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1J4J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_79857_1 316067.Geob_1313 5.09e-42 149.0 COG3359@1|root,COG3359@2|Bacteria,1R6A2@1224|Proteobacteria,42MVN@68525|delta/epsilon subdivisions,2WK0C@28221|Deltaproteobacteria 28221|Deltaproteobacteria L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_163853_1 1049564.TevJSym_ae00330 2.24e-47 173.0 28IG4@1|root,2Z8HN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_118685_1 1158165.KB898881_gene674 3.13e-71 228.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1WY05@135613|Chromatiales 135613|Chromatiales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_98776_1 1265505.ATUG01000001_gene3881 3.96e-66 223.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_92703_1 1499967.BAYZ01000016_gene6497 1.11e-64 201.0 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity - - - - - - - - - - - - 4HBT k59_66487_1 1117318.PRUB_04216 8.48e-22 99.8 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,2Q0ZC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB k59_144605_1 395493.BegalDRAFT_1318 1.17e-55 184.0 2C8AR@1|root,341QR@2|Bacteria,1NYPB@1224|Proteobacteria,1SQFU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_86049_1 909663.KI867150_gene2362 1.45e-32 117.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MRP5@213462|Syntrophobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_86049_2 1121413.JMKT01000011_gene2307 7.31e-48 156.0 COG2391@1|root,COG2391@2|Bacteria,1RDQK@1224|Proteobacteria,42RU6@68525|delta/epsilon subdivisions,2WNJT@28221|Deltaproteobacteria,2MBSU@213115|Desulfovibrionales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_34261_1 1123354.AUDR01000018_gene1176 1.1e-22 94.4 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,2VRJ4@28216|Betaproteobacteria,1KRUU@119069|Hydrogenophilales 119069|Hydrogenophilales O FKBP-type peptidyl-prolyl cis-trans isomerase - - - - - - - - - - - - FKBP_C k59_40892_1 530564.Psta_1838 1.58e-114 355.0 COG0542@1|root,COG0542@2|Bacteria,2IWVE@203682|Planctomycetes 203682|Planctomycetes O TIGRFAM type VI secretion ATPase, ClpV1 family - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small k59_60175_1 543728.Vapar_4055 0.000162 48.9 COG1106@1|root,COG1106@2|Bacteria,1QZ0M@1224|Proteobacteria,2VXVM@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA ATPase domain - - - - - - - - - - - - AAA_15,AAA_21 k59_131668_1 617140.AJZE01000079_gene1787 3.48e-10 70.5 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1R81Y@1224|Proteobacteria,1RYQ2@1236|Gammaproteobacteria,1XSR3@135623|Vibrionales 135623|Vibrionales T COG0642 Signal transduction histidine kinase cqsS GO:0000155,GO:0000156,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K10916 ko02020,ko02024,ko05111,map02020,map02024,map05111 M00513 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_47165_1 1049564.TevJSym_ap00570 1.54e-121 357.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J4GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_118691_1 1049564.TevJSym_aa00040 6e-49 157.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1J6R9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_118691_2 1049564.TevJSym_aa00030 2.85e-97 288.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1J4YN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the polypeptide exit tunnel rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_118691_3 203122.Sde_0960 4e-97 288.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,465E3@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_176870_1 1026882.MAMP_00106 0.0 1767.0 COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria,461SC@72273|Thiotrichales 72273|Thiotrichales L Tn3 transposase DDE domain - - - - - - - - - - - - DDE_Tnp_Tn3,DUF4158 k59_176870_2 1120999.JONM01000006_gene2350 4.82e-54 170.0 COG1669@1|root,COG1669@2|Bacteria,1N17I@1224|Proteobacteria,2VVYD@28216|Betaproteobacteria,2KRYR@206351|Neisseriales 206351|Neisseriales S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 k59_176870_3 228410.NE1074 2.03e-63 196.0 COG2361@1|root,COG2361@2|Bacteria,1PTAI@1224|Proteobacteria,2WAFY@28216|Betaproteobacteria,374GY@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 k59_144612_1 667632.KB890165_gene2241 1.76e-48 175.0 COG3300@1|root,COG4251@1|root,COG3300@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJGY@28216|Betaproteobacteria,1KGEK@119060|Burkholderiaceae 28216|Betaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_9,TarH k59_189850_1 1499967.BAYZ01000163_gene6592 3.94e-98 293.0 COG1638@1|root,COG1638@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP k59_21386_1 1225184.ALXE01000033_gene3155 6.31e-59 194.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,3VXY5@53335|Pantoea 1236|Gammaproteobacteria I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_66495_1 1166948.JPZL01000004_gene64 5.99e-48 172.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1XMBH@135619|Oceanospirillales 135619|Oceanospirillales M Sulfatase - - - - - - - - - - - - Sulfatase k59_98788_1 1121405.dsmv_1320 9.41e-128 390.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_86055_1 335543.Sfum_2640 1.43e-40 144.0 29QS6@1|root,30BS1@2|Bacteria,1REGY@1224|Proteobacteria,42RJ2@68525|delta/epsilon subdivisions,2WNQQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_183554_1 1232410.KI421421_gene3374 1.49e-43 155.0 2AK27@1|root,31ARV@2|Bacteria,1REZR@1224|Proteobacteria,42W34@68525|delta/epsilon subdivisions,2WRFM@28221|Deltaproteobacteria,43VW3@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_183554_2 1198232.CYCME_1949 1.02e-24 105.0 COG0189@1|root,COG0569@1|root,COG0189@2|Bacteria,COG0569@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,4609Y@72273|Thiotrichales 1236|Gammaproteobacteria HJ Belongs to the RimK family rimK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_14455_1 2340.JV46_19980 1.93e-221 615.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1J56Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Citrate synthase, C-terminal domain prpC GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630 Citrate_synt k59_137691_2 640081.Dsui_1098 1.57e-08 56.6 COG0640@1|root,COG0640@2|Bacteria,1RBZC@1224|Proteobacteria,2VR13@28216|Betaproteobacteria,2KW3M@206389|Rhodocyclales 206389|Rhodocyclales K Transcriptional regulator - - - - - - - - - - - - - k59_60179_1 1049564.TevJSym_ax00180 7.6e-86 266.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1JBWE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M NlpB/DapX lipoprotein bamC - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_60179_2 1397528.Q671_09410 4.88e-85 261.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1XJCR@135619|Oceanospirillales 135619|Oceanospirillales S beta-lactamase - - - - - - - - - - - - Lactamase_B_2 k59_157360_1 1049564.TevJSym_br00020 1.24e-238 707.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_131677_1 1249627.D779_0371 8.43e-37 133.0 COG0304@1|root,COG0304@2|Bacteria,1NP8M@1224|Proteobacteria,1S4JR@1236|Gammaproteobacteria,1WYSP@135613|Chromatiales 135613|Chromatiales IQ Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - Ketoacyl-synt_2 k59_131677_2 555778.Hneap_2239 8.8e-101 306.0 COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,1WXR7@135613|Chromatiales 135613|Chromatiales IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_8289_1 880072.Desac_0563 7.61e-87 274.0 COG0119@1|root,COG0119@2|Bacteria,1R8DM@1224|Proteobacteria,42PDN@68525|delta/epsilon subdivisions,2WKIJ@28221|Deltaproteobacteria,2MQ4N@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Pyruvate carboxyltransferase - - - - - - - - - - - - HMGL-like,dCache_1 k59_112079_1 1313421.JHBV01000144_gene1168 3.05e-107 328.0 COG0286@1|root,COG0286@2|Bacteria,4NJ3U@976|Bacteroidetes,1IYCD@117747|Sphingobacteriia 976|Bacteroidetes V Type I restriction enzyme R protein N terminus (HSDR_N) - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HSDR_N_2,Methylase_S,N6_Mtase k59_185814_1 1232437.KL661954_gene2334 6.63e-128 377.0 COG0174@1|root,COG0174@2|Bacteria,1R9JP@1224|Proteobacteria,42P33@68525|delta/epsilon subdivisions,2WKP3@28221|Deltaproteobacteria,2MN2Q@213118|Desulfobacterales 28221|Deltaproteobacteria E Glutamine synthetase, catalytic domain - - - - - - - - - - - - Gln-synt_C,Gln-synt_N k59_113945_1 1307759.JOMJ01000003_gene1897 1.13e-12 69.3 COG0730@1|root,COG0730@2|Bacteria,1RB0E@1224|Proteobacteria,42YSI@68525|delta/epsilon subdivisions,2WUFZ@28221|Deltaproteobacteria,2MECT@213115|Desulfovibrionales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_172268_1 84531.JMTZ01000050_gene887 6.86e-20 87.0 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1X6ZM@135614|Xanthomonadales 135614|Xanthomonadales NT Two component signalling adaptor domain - - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_172268_2 622637.KE124770_gene186 3.28e-27 105.0 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver divK - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_172268_3 187272.Mlg_0355 1.68e-68 211.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_100695_1 933262.AXAM01000003_gene2821 7.1e-62 204.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_68878_1 1049564.TevJSym_ad00460 1.59e-32 120.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria 1224|Proteobacteria P Na H antiporter, MnhB - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_68878_2 1049564.TevJSym_ad00480 2.44e-52 170.0 COG1006@1|root,COG1006@2|Bacteria,1QP28@1224|Proteobacteria,1SINF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_121111_1 522306.CAP2UW1_1132 1.27e-157 479.0 29GCA@1|root,303A5@2|Bacteria,1NC46@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_68879_1 1304885.AUEY01000002_gene422 1.35e-68 218.0 COG1639@1|root,COG1639@2|Bacteria,1QIEZ@1224|Proteobacteria,42PKV@68525|delta/epsilon subdivisions,2WKGI@28221|Deltaproteobacteria,2MJBD@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_204696_1 457570.Nther_2931 1.83e-25 103.0 COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia 186801|Clostridia S R3H domain protein jag - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_204696_2 335543.Sfum_2597 1.58e-115 348.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MQBM@213462|Syntrophobacterales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_81852_1 1121439.dsat_0639 1.87e-118 364.0 COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,2MEF8@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_179073_1 349521.HCH_06851 3.75e-51 181.0 2E09B@1|root,32VWY@2|Bacteria,1PA33@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_49274_2 1122134.KB893650_gene467 4.08e-42 147.0 COG2050@1|root,COG2050@2|Bacteria,1N5HF@1224|Proteobacteria,1RNAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q protein possibly involved in aromatic compounds catabolism yigI GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - 4HBT k59_49274_3 933262.AXAM01000026_gene3066 8.95e-64 202.0 COG1456@1|root,COG1456@2|Bacteria,1RGBW@1224|Proteobacteria,42S7W@68525|delta/epsilon subdivisions,2WNEP@28221|Deltaproteobacteria,2MKAQ@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786 k59_172272_1 293826.Amet_0347 2.49e-26 104.0 COG0636@1|root,COG0636@2|Bacteria,1V1B0@1239|Firmicutes,24G2R@186801|Clostridia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - - - - - - - - - - ATP-synt_C k59_62502_1 696369.KI912183_gene956 1.35e-07 55.5 COG5001@1|root,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9,Response_reg k59_113950_1 1121405.dsmv_0661 6.44e-81 248.0 COG0517@1|root,COG0517@2|Bacteria,1PDG6@1224|Proteobacteria,42QQ0@68525|delta/epsilon subdivisions,2WMQ6@28221|Deltaproteobacteria,2MKN2@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM CBS domain - - - ko:K04767 - - - - ko00000 - - - CBS k59_43652_1 384676.PSEEN2113 4.37e-33 132.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - AHH,RHS,RHS_repeat k59_127782_1 1232437.KL662037_gene2261 1.75e-23 92.4 COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_127782_3 658086.HMPREF0994_06504 4.27e-07 59.7 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,27IEC@186928|unclassified Lachnospiraceae 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg k59_127782_4 261292.Nit79A3_1075 6.83e-153 443.0 COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_55222_1 587753.EY04_00810 1.02e-113 349.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K accessory protein yhgF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_62507_1 335543.Sfum_3130 2.77e-06 48.1 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MRE6@213462|Syntrophobacterales 28221|Deltaproteobacteria H Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - CdhD,MTHFR k59_62507_2 1123400.KB904813_gene3016 3.6e-14 72.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,462JI@72273|Thiotrichales 72273|Thiotrichales KT PFAM Response regulator receiver domain - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_133696_3 743721.Psesu_0674 4.15e-18 83.6 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1X3CZ@135614|Xanthomonadales 135614|Xanthomonadales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_107661_1 1049564.TevJSym_ak00790 4.69e-47 155.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1J6GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698 - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_107661_2 1049564.TevJSym_ak00780 1.5e-43 154.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_95413_1 765910.MARPU_01260 3.4e-56 192.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_95413_2 765911.Thivi_3239 1.84e-24 99.0 COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,1RYXQ@1236|Gammaproteobacteria,1WX88@135613|Chromatiales 135613|Chromatiales K GntR family - - - - - - - - - - - - FCD,GntR k59_68886_2 1117647.M5M_14585 2.57e-23 98.2 COG0044@1|root,COG0044@2|Bacteria,1NGXW@1224|Proteobacteria,1SV52@1236|Gammaproteobacteria,1JBNS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F PEP-CTERM motif - - - - - - - - - - - - VPEP k59_10493_1 1049564.TevJSym_aw00120 2.55e-104 322.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster dsrL - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2 k59_43919_1 1049564.TevJSym_aq00060 9.08e-210 587.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1J4KI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_10715_2 998674.ATTE01000001_gene239 7.36e-157 456.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,460KI@72273|Thiotrichales 72273|Thiotrichales P Biological Process cation transport (GO 0006812), Molecular Function solute hydrogen antiporter activity (GO 0015299), Cellular Component integral to membrane (GO 0016021), Biological Process transmembrane transport (GO 0055085) - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_153044_2 1279017.AQYJ01000019_gene1494 3.84e-26 99.8 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,467QN@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds directly to 16S ribosomal RNA rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_74947_2 933262.AXAM01000021_gene458 1.5e-14 77.8 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,42P27@68525|delta/epsilon subdivisions,2WK9Y@28221|Deltaproteobacteria,2MJZE@213118|Desulfobacterales 28221|Deltaproteobacteria PT FecR protein - - - - - - - - - - - - FecR,TPR_16,TPR_8,TonB_dep_Rec,zinc_ribbon_4 k59_133908_1 335543.Sfum_0424 2.05e-130 389.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MQSY@213462|Syntrophobacterales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_43923_1 765913.ThidrDRAFT_0838 2.72e-74 244.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WXBA@135613|Chromatiales 135613|Chromatiales G PEP-utilising enzyme, mobile - - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 k59_179258_2 709032.Sulku_1948 0.000642 45.1 COG2197@1|root,COG2197@2|Bacteria,1Q4EG@1224|Proteobacteria,42Z0G@68525|delta/epsilon subdivisions,2YRJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_16504_1 1173020.Cha6605_1221 7.69e-36 152.0 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1GHFQ@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Response_reg k59_139836_1 706587.Desti_4650 5.59e-26 107.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M8C@68525|delta/epsilon subdivisions,2WJIB@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,Sigma54_activat k59_198040_1 694429.Pyrfu_0824 3.69e-34 130.0 COG1228@1|root,arCOG00696@2157|Archaea,2XRTE@28889|Crenarchaeota 28889|Crenarchaeota Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_128002_1 1183438.GKIL_3136 8.49e-16 81.6 COG0617@1|root,COG0617@2|Bacteria,1G1NC@1117|Cyanobacteria 1117|Cyanobacteria H tRNA nucleotidyltransferase poly(A) polymerase pcnB - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_146715_1 305900.GV64_22690 5.2e-66 205.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XJQQ@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_74954_1 1499683.CCFF01000017_gene2597 1.93e-24 103.0 28PQ6@1|root,2ZCCB@2|Bacteria,1V1NK@1239|Firmicutes,24F19@186801|Clostridia,36GJ8@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_204844_1 439235.Dalk_3465 6.98e-176 529.0 COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MIS3@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM UvrD REP helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_204844_2 338966.Ppro_3458 2.51e-115 370.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43T7Y@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_204844_3 63737.Npun_F0305 1.64e-05 57.8 COG2931@1|root,COG2931@2|Bacteria,1GQCK@1117|Cyanobacteria 1117|Cyanobacteria Q PFAM Hemolysin-type calcium-binding - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,DUF4347,HemolysinCabind,VCBS k59_192021_2 1417599.U6C697_9CAUD 1.36e-39 156.0 4QBFN@10239|Viruses,4QXWN@35237|dsDNA viruses no RNA stage,4QPTW@28883|Caudovirales,4QNPZ@10744|Podoviridae 10744|Podoviridae S Phage stabilisation protein - - - - - - - - - - - - - k59_10729_1 1049564.TevJSym_ao00150 5.13e-56 182.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1J4WK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_88272_1 1123368.AUIS01000006_gene591 1.59e-36 129.0 COG1846@1|root,COG1846@2|Bacteria,1RM3A@1224|Proteobacteria,1SSFM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 k59_165886_2 765913.ThidrDRAFT_0524 4.79e-38 131.0 COG2010@1|root,COG2010@2|Bacteria,1RD7T@1224|Proteobacteria,1SZ7R@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c mono- and diheme variants - - - - - - - - - - - - Cytochrome_CBB3 k59_139849_1 1120956.JHZK01000020_gene2119 2.57e-78 249.0 COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_107896_1 622637.KE124774_gene3531 4.88e-38 132.0 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,2UNIW@28211|Alphaproteobacteria,36Z1T@31993|Methylocystaceae 28211|Alphaproteobacteria P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_107896_3 1249627.D779_3155 1.49e-170 488.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RRGA@1236|Gammaproteobacteria,1WX0C@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_107896_5 765912.Thimo_3233 2.58e-46 157.0 COG0457@1|root,COG0457@2|Bacteria,1R714@1224|Proteobacteria,1SA9Y@1236|Gammaproteobacteria,1WY64@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_107896_9 1415755.JQLV01000002_gene234 2.28e-17 79.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,1XM0E@135619|Oceanospirillales 135619|Oceanospirillales L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_49490_5 314230.DSM3645_12711 8.13e-14 84.3 COG1994@1|root,COG1994@2|Bacteria,2J1E1@203682|Planctomycetes 203682|Planctomycetes S Peptidase family M50 - - - - - - - - - - - - - k59_49490_10 1049564.TevJSym_ag00060 0.000109 43.5 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1J56A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0625 Glutathione S-transferase sspA GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N,GST_N_3 k59_165887_1 243159.AFE_1603 2.08e-33 127.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_172432_1 765910.MARPU_12280 2.55e-37 141.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WX5R@135613|Chromatiales 135613|Chromatiales I aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_43949_1 305900.GV64_09685 1.59e-59 194.0 28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,1RP8T@1236|Gammaproteobacteria,1XIH6@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_153059_1 1049564.TevJSym_aa02290 5e-259 737.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_146728_1 439235.Dalk_0487 1.32e-111 344.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_3518_1 1254432.SCE1572_34585 1.69e-18 84.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) tnp3510a - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_139858_1 244447.XP_008321166.1 3.19e-26 107.0 COG2086@1|root,KOG3180@2759|Eukaryota,38DVE@33154|Opisthokonta,3BCQ1@33208|Metazoa,3CW63@33213|Bilateria,486X1@7711|Chordata,495U8@7742|Vertebrata,49URR@7898|Actinopterygii 33208|Metazoa C Electron-transfer-flavoprotein, beta polypeptide ETFB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007399,GO:0007406,GO:0008150,GO:0008152,GO:0008285,GO:0009055,GO:0009056,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010721,GO:0016042,GO:0016054,GO:0016310,GO:0016491,GO:0017133,GO:0017144,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0022008,GO:0022900,GO:0030154,GO:0030258,GO:0031974,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0033539,GO:0034440,GO:0034641,GO:0042127,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045251,GO:0045595,GO:0045596,GO:0046034,GO:0046395,GO:0046483,GO:0048519,GO:0048523,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051239,GO:0051241,GO:0051960,GO:0051961,GO:0055086,GO:0055114,GO:0060284,GO:0065007,GO:0070013,GO:0071704,GO:0072091,GO:0072329,GO:0072521,GO:0098798,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1902494,GO:1902692,GO:1990204,GO:2000026,GO:2000177,GO:2000178,GO:2000647 - ko:K03521 - - - - ko00000 - - - ETF k59_103455_1 1121396.KB892990_gene4479 1.5e-76 237.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42R15@68525|delta/epsilon subdivisions,2WJR6@28221|Deltaproteobacteria,2MIHT@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_103458_1 880073.Calab_3321 1.97e-92 297.0 COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_174694_1 526222.Desal_3190 9.29e-99 304.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2M885@213115|Desulfovibrionales 28221|Deltaproteobacteria T elongation factor Tu domain 2 protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_5974_1 436308.Nmar_1604 3.19e-20 91.3 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_174704_2 395493.BegalDRAFT_2989 1.66e-09 60.1 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,45ZU7@72273|Thiotrichales 72273|Thiotrichales M transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_174708_1 331678.Cphamn1_1921 4.1e-45 162.0 COG3039@1|root,COG3039@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_207105_2 857087.Metme_0224 4.55e-107 314.0 COG5285@1|root,COG5285@2|Bacteria,1R9W1@1224|Proteobacteria,1S7VN@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_207105_3 1279038.KB907337_gene237 3.32e-16 78.6 COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria,2JS9Y@204441|Rhodospirillales 204441|Rhodospirillales S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_207105_4 550540.Fbal_0393 3.35e-16 76.3 COG1247@1|root,COG1247@2|Bacteria,1QUGY@1224|Proteobacteria,1T1YJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0454 Histone acetyltransferase HPA2 and related acetyltransferases yhhY GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - ko:K03825 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_207105_5 247634.GPB2148_780 1.48e-50 168.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NnrU protein nnrU - - - - - - - - - - - NnrU k59_207105_7 1353276.JADR01000011_gene1557 1.86e-06 53.5 COG4932@1|root,COG4932@2|Bacteria,4NXB2@976|Bacteroidetes 976|Bacteroidetes M domain protein - - - - - - - - - - - - - k59_207105_8 279714.FuraDRAFT_0922 1.48e-37 147.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,2VKF9@28216|Betaproteobacteria,2KR53@206351|Neisseriales 206351|Neisseriales G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_207105_9 243159.AFE_2412 5.43e-23 99.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,1RNSN@1236|Gammaproteobacteria 1236|Gammaproteobacteria GT COG0574 Phosphoenolpyruvate synthase pyruvate phosphate dikinase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 2.7.9.2 ko:K01007,ko:K21787 ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00374,M00837,M00838 R00199,R11662,R11673 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_200585_1 909663.KI867150_gene213 3.47e-54 190.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_207112_1 1049564.TevJSym_at00590 1.39e-124 374.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1J4RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_6005_1 1499967.BAYZ01000186_gene3985 2.29e-42 156.0 COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_103501_1 1069080.KB913028_gene62 2.32e-46 158.0 COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,4H20D@909932|Negativicutes 909932|Negativicutes M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_77636_1 314278.NB231_12496 5.52e-97 307.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_200610_1 1894.JOER01000063_gene132 2.15e-31 122.0 COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria 201174|Actinobacteria L Transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_174723_1 1234364.AMSF01000056_gene1199 2.2e-26 102.0 COG3518@1|root,COG3518@2|Bacteria,1RF51@1224|Proteobacteria,1S7ZZ@1236|Gammaproteobacteria,1X6RV@135614|Xanthomonadales 135614|Xanthomonadales S Gene 25-like lysozyme - - - ko:K11897 - M00334 - - ko00000,ko00002,ko02044 - - - GPW_gp25 k59_174723_2 765911.Thivi_2287 9.71e-101 301.0 COG4455@1|root,COG4455@2|Bacteria,1MWHI@1224|Proteobacteria,1RXYE@1236|Gammaproteobacteria,1X0IJ@135613|Chromatiales 135613|Chromatiales S ImpE protein - - - ko:K11898 - - - - ko00000,ko02044 - - - ImpE k59_174723_3 318167.Sfri_0960 9.5e-33 122.0 COG0666@1|root,COG0666@2|Bacteria,1P2CN@1224|Proteobacteria,1SSTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S response to abiotic stimulus - - - - - - - - - - - - - k59_174723_5 1097668.BYI23_C003610 7.64e-17 79.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,2VKCP@28216|Betaproteobacteria,1K2U0@119060|Burkholderiaceae 28216|Betaproteobacteria S type VI secretion protein - - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_200614_2 1049564.TevJSym_ao00020 3.81e-19 86.3 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1J4IU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases visC - - ko:K03184,ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R06146,R08768,R08773,R08775 RC00046,RC01254,RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3,SE k59_174729_1 1121405.dsmv_0691 2.09e-69 225.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_19372_1 391625.PPSIR1_26031 7.93e-97 296.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria,2YU3Q@29|Myxococcales 28221|Deltaproteobacteria H Aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_6048_2 59538.XP_005967818.1 3.68e-23 104.0 COG0277@1|root,COG0351@1|root,KOG1231@2759|Eukaryota,KOG1232@2759|Eukaryota,KOG2598@2759|Eukaryota,38FXH@33154|Opisthokonta,3BEEV@33208|Metazoa,3CRTP@33213|Bilateria,4801S@7711|Chordata,492UT@7742|Vertebrata,3JDRF@40674|Mammalia,4J43Y@91561|Cetartiodactyla 33154|Opisthokonta C dehydrogenase - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_6050_1 386456.JQKN01000014_gene3153 1.69e-57 192.0 arCOG11926@1|root,arCOG11926@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_77672_1 1123368.AUIS01000032_gene1398 9.18e-122 374.0 COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Pfam SNARE associated Golgi protein - - - - - - - - - - - - PLDc,PLDc_2,SNARE_assoc k59_19391_1 309807.SRU_0709 1.29e-69 223.0 COG1063@1|root,COG1063@2|Bacteria,4NE11@976|Bacteroidetes,1FJZM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Alcohol dehydrogenase GroES-associated yjmD_2 - - ko:K18369 ko00640,map00640 - R10703 RC00545 ko00000,ko00001,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N,ADH_zinc_N_2 k59_6063_2 572477.Alvin_3094 4.37e-264 738.0 COG3344@1|root,COG3344@2|Bacteria,1RD41@1224|Proteobacteria,1SASD@1236|Gammaproteobacteria,1WZT3@135613|Chromatiales 135613|Chromatiales L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_6063_3 572477.Alvin_3093 1.39e-89 272.0 29SS3@1|root,30DY0@2|Bacteria,1NH1Z@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_19396_1 765913.ThidrDRAFT_3308 1.31e-99 301.0 COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales 135613|Chromatiales S Bacterial lipid A biosynthesis acyltransferase - - - - - - - - - - - - Lip_A_acyltrans k59_19396_2 84531.JMTZ01000016_gene1126 4.18e-16 74.7 COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X7W5@135614|Xanthomonadales 135614|Xanthomonadales I dehydratase - - - - - - - - - - - - FabA k59_19396_3 90813.JQMT01000001_gene670 1.86e-26 99.8 COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,4639A@72273|Thiotrichales 72273|Thiotrichales IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_6076_1 717774.Marme_4093 1.33e-153 447.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RY92@1236|Gammaproteobacteria,1XP3P@135619|Oceanospirillales 135619|Oceanospirillales C FAD-NAD(P)-binding - - 1.14.13.8 ko:K00485 ko00982,ko01120,map00982,map01120 - R08266 RC02233 ko00000,ko00001,ko01000 - - - FMO-like k59_6081_1 1121121.KB894318_gene3954 3.6e-08 57.8 COG1309@1|root,COG1309@2|Bacteria,1VJ8P@1239|Firmicutes,4HQG7@91061|Bacilli,270VT@186822|Paenibacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_57951_1 1123355.JHYO01000027_gene2045 9.25e-68 226.0 COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,36XJA@31993|Methylocystaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9 k59_57951_2 1238450.VIBNISOn1_1130006 2.87e-84 262.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,1XUEH@135623|Vibrionales 135623|Vibrionales P ABC-type phosphate phosphonate transport system, periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_77690_2 596152.DesU5LDRAFT_0932 5.29e-83 273.0 2E2CM@1|root,32XHK@2|Bacteria,1PZ5F@1224|Proteobacteria,435QW@68525|delta/epsilon subdivisions,2X9C3@28221|Deltaproteobacteria,2MAMB@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_174789_1 243233.MCA1818 2.51e-18 89.4 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XE33@135618|Methylococcales 135618|Methylococcales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_103586_1 330214.NIDE3284 2.36e-46 182.0 COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae 40117|Nitrospirae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DUF3365,HAMP,HATPase_c,HisKA,PAS_4 k59_174793_1 56780.SYN_01623 9.7e-16 77.0 COG2159@1|root,COG2159@2|Bacteria,1RJPH@1224|Proteobacteria,42T4E@68525|delta/epsilon subdivisions,2WPSE@28221|Deltaproteobacteria,2MRNU@213462|Syntrophobacterales 28221|Deltaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_77692_2 1049564.TevJSym_as00150 2.05e-86 274.0 COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acid phosphatase homologues lssY - - ko:K03975 - - - - ko00000 - - - LssY_C,PAP2,SNARE_assoc k59_207203_1 1265505.ATUG01000003_gene822 3.26e-21 86.7 COG2204@1|root,COG2204@2|Bacteria,1RHQV@1224|Proteobacteria,42T2A@68525|delta/epsilon subdivisions,2WPA0@28221|Deltaproteobacteria,2MKC4@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_207203_2 1121472.AQWN01000008_gene1913 9.63e-08 60.5 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Pyr_redox_2 k59_77694_2 550540.Fbal_0090 4.01e-14 73.2 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S penicillin-binding protein - - - - - - - - - - - - BiPBP_C,DUF4124 k59_71532_1 713587.THITH_12055 6.33e-27 110.0 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_84447_1 644282.Deba_1503 4.98e-70 223.0 COG0500@1|root,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,42M58@68525|delta/epsilon subdivisions,2WK5Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria OQ PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_6703_1 1096546.WYO_5944 2.74e-57 204.0 COG0784@1|root,COG3920@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JQYU@119045|Methylobacteriaceae 28211|Alphaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_149305_1 335543.Sfum_2084 1.37e-92 293.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MQ60@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM leucyl-tRNA synthetase leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_142801_2 933262.AXAM01000193_gene3044 6.05e-102 306.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein) - - - - - - - - - - - - rve k59_201193_1 933262.AXAM01000040_gene1210 9.73e-73 232.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2MIZ6@213118|Desulfobacterales 28221|Deltaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_52095_1 222534.KB893766_gene2938 2.56e-12 67.4 COG1961@1|root,COG1961@2|Bacteria,2ID9R@201174|Actinobacteria 201174|Actinobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - HTH_17,Recombinase,Resolvase,Zn_ribbon_recom k59_136341_1 1121405.dsmv_1696 1.45e-76 249.0 COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2MHX7@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase - - - - - - - - - - - - DEAD,DSHCT,DUF3516,Helicase_C k59_39085_1 485915.Dret_2536 4.65e-125 368.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria,2M94G@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_39085_2 1121413.JMKT01000003_gene160 5.27e-36 130.0 COG2963@1|root,COG2963@2|Bacteria,1R1TN@1224|Proteobacteria 1224|Proteobacteria L transposase activity - - - - - - - - - - - - HTH_Tnp_1 k59_32639_1 90814.KL370892_gene1939 2.95e-91 276.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,45ZXW@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_6721_1 1283300.ATXB01000002_gene2696 1.6e-149 465.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XFKT@135618|Methylococcales 135618|Methylococcales T PFAM Chemotaxis methyl-accepting receptor, signalling - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9,TarH k59_6721_2 316275.VSAL_II0540 5.32e-29 110.0 COG0454@1|root,COG0454@2|Bacteria,1QYXF@1224|Proteobacteria,1T3WM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Protein conserved in bacteria - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_6721_3 1304872.JAGC01000005_gene1979 4.98e-140 402.0 COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,42UUC@68525|delta/epsilon subdivisions,2WQFQ@28221|Deltaproteobacteria,2M9IH@213115|Desulfovibrionales 28221|Deltaproteobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_162329_1 631362.Thi970DRAFT_00505 8.01e-09 55.5 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1WVW3@135613|Chromatiales 135613|Chromatiales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_162329_2 765911.Thivi_4145 3.98e-56 186.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_162329_3 231434.JQJH01000018_gene3066 1.45e-05 46.2 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,3N9Y2@45404|Beijerinckiaceae 28211|Alphaproteobacteria E dihydroxy-acid dehydratase activity ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_194611_1 1230476.C207_04925 1.01e-69 214.0 COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,2U7MF@28211|Alphaproteobacteria,3JYXW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_52103_1 1121405.dsmv_0111 7.85e-73 231.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM peptidase M20 argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_47315_1 1217718.ALOU01000112_gene4314 6.61e-74 237.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_202937_1 1121405.dsmv_3071 2.39e-120 351.0 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2MI8X@213118|Desulfobacterales 28221|Deltaproteobacteria ET SMART ABC-type transporter, periplasmic subunit family 3, ionotropic glutamate receptor - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_118907_1 655811.HMPREF0078_1204 1.97e-06 50.4 COG0286@1|root,COG0286@2|Bacteria,1UZUD@1239|Firmicutes,24N15@186801|Clostridia 186801|Clostridia V N-6 DNA Methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HSDR_N_2,N6_Mtase k59_118907_2 655811.HMPREF0078_1203 8.61e-39 145.0 COG0732@1|root,COG0732@2|Bacteria 2|Bacteria V type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_137826_1 526222.Desal_2666 1.15e-45 166.0 COG0303@1|root,COG2191@1|root,COG0303@2|Bacteria,COG2191@2|Bacteria,1MYKY@1224|Proteobacteria,42NIJ@68525|delta/epsilon subdivisions,2WJ0M@28221|Deltaproteobacteria,2M7RP@213115|Desulfovibrionales 28221|Deltaproteobacteria CH PFAM Formylmethanofuran dehydrogenase, subunit E region - - 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - FmdE,MoCF_biosynth k59_92943_1 1121405.dsmv_1599 9.01e-28 112.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_92943_2 177437.HRM2_12300 5.32e-27 99.8 COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria,2MKZY@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_105557_2 1123023.JIAI01000007_gene1668 5.34e-26 112.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2GIXM@201174|Actinobacteria,4E5SG@85010|Pseudonocardiales 201174|Actinobacteria M PFAM Polysaccharide biosynthesis protein capD - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 k59_73093_1 243231.GSU3245 7.52e-95 300.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase type-B family polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 k59_112214_1 1121405.dsmv_0987 1.41e-124 385.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MI86@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_86250_1 1121033.AUCF01000037_gene3935 7.05e-15 76.3 COG0745@1|root,COG0745@2|Bacteria,1MWER@1224|Proteobacteria,2TUCU@28211|Alphaproteobacteria,2JVYH@204441|Rhodospirillales 204441|Rhodospirillales KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_79988_1 765913.ThidrDRAFT_4451 2.12e-60 208.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_131883_1 485915.Dret_1710 5.5e-42 145.0 COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,42RNB@68525|delta/epsilon subdivisions,2WNEW@28221|Deltaproteobacteria,2MBFV@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Metallophosphoesterase - - - - - - - - - - - - Metallophos_2 k59_137829_1 1049564.TevJSym_af00790 3.15e-126 372.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Virulence factor BrkB rbn GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_53699_1 566466.NOR53_2559 2.84e-27 111.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_86252_1 754477.Q7C_2662 2.67e-06 48.5 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,460IF@72273|Thiotrichales 72273|Thiotrichales JM PFAM Nucleotidyl transferase - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_86252_2 570268.ANBB01000080_gene4322 1.35e-11 64.3 COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria,4EFTR@85012|Streptosporangiales 201174|Actinobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_183814_1 1122194.AUHU01000005_gene963 1.27e-157 490.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,1T315@1236|Gammaproteobacteria,46AA9@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - AAA_16,GAF,GGDEF,Pkinase k59_47325_1 1122603.ATVI01000006_gene270 3.44e-21 87.8 2E7KC@1|root,3322E@2|Bacteria,1PUQ1@1224|Proteobacteria,1TAQ9@1236|Gammaproteobacteria,1XBP4@135614|Xanthomonadales 135614|Xanthomonadales S multidrug transporter - - - - - - - - - - - - - k59_92951_1 1158292.JPOE01000005_gene201 8.43e-08 52.8 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria,1KNEP@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Domain of unknown function (DUF1932) - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - DUF1932,NAD_binding_2 k59_92951_2 292.DM42_7333 3.56e-86 259.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VICR@28216|Betaproteobacteria,1K078@119060|Burkholderiaceae 28216|Betaproteobacteria H PFAM Dimethylmenaquinone methyltransferase ligK - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_144818_1 472759.Nhal_1160 1.6e-87 272.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X09F@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_73095_1 439235.Dalk_5089 5.85e-172 497.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.6.5.3 ko:K00124,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_131886_1 572477.Alvin_3086 9.6e-55 179.0 COG0622@1|root,COG0622@2|Bacteria,1N8BH@1224|Proteobacteria,1S1KD@1236|Gammaproteobacteria,1WWKY@135613|Chromatiales 135613|Chromatiales S Phosphoesterase - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_190060_1 1049564.TevJSym_bh00150 3.09e-66 217.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1J5FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_190060_2 768671.ThimaDRAFT_2775 1.18e-107 317.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1WWX5@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_98955_1 439235.Dalk_4811 8.84e-59 205.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_118926_1 96561.Dole_2694 9.89e-122 358.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2MHKY@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_170846_1 335543.Sfum_1208 7.93e-138 398.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MR0A@213462|Syntrophobacterales 28221|Deltaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N k59_79995_1 1049564.TevJSym_ap00450 2.06e-131 406.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1737_1 1397527.Q670_11310 2.36e-56 176.0 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1S83W@1236|Gammaproteobacteria,1XMN6@135619|Oceanospirillales 135619|Oceanospirillales K Helix-turn-helix - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_1737_2 880070.Cycma_1550 3.13e-17 77.0 COG3549@1|root,COG3549@2|Bacteria,4NSZ2@976|Bacteroidetes,47RJA@768503|Cytophagia 976|Bacteroidetes S PFAM Plasmid maintenance system killer - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_119149_4 1211114.ALIP01000164_gene2786 3.16e-06 49.3 2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,1X7KN@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_80176_1 1029823.AFIE01000006_gene1340 3.04e-18 89.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,3NIQ4@468|Moraxellaceae 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_60571_1 1049564.TevJSym_av00270 1.38e-34 134.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1J539@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. prsK - - - - - - - - - - - GAF_2,HATPase_c k59_99149_1 1049564.TevJSym_bb00240 2.1e-175 500.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1J4PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_41400_1 706587.Desti_1174 5.93e-40 137.0 COG2204@1|root,COG2204@2|Bacteria,1RKC4@1224|Proteobacteria,42SJ3@68525|delta/epsilon subdivisions,2WPI1@28221|Deltaproteobacteria,2MRU7@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_41400_2 1121406.JAEX01000001_gene426 3.7e-46 160.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2M81I@213115|Desulfovibrionales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_203155_1 96561.Dole_2273 1.71e-47 164.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MJ5M@213118|Desulfobacterales 28221|Deltaproteobacteria E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_105798_1 1049564.TevJSym_am00820 4.62e-203 573.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1J5BJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0022411,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032984,GO:0034641,GO:0034645,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_125646_1 348780.NP_1078A 1.48e-13 71.6 COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,23X30@183963|Halobacteria 183963|Halobacteria O Belongs to the small heat shock protein (HSP20) family hsp20a - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_73292_1 1049564.TevJSym_av00050 3.49e-98 291.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_73292_2 765912.Thimo_3048 6.56e-34 120.0 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1WYXS@135613|Chromatiales 135613|Chromatiales S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_105799_1 933262.AXAM01000043_gene1197 5.11e-85 259.0 COG1465@1|root,COG1465@2|Bacteria,1P42W@1224|Proteobacteria,42MQM@68525|delta/epsilon subdivisions,2WK5X@28221|Deltaproteobacteria,2MIRC@213118|Desulfobacterales 28221|Deltaproteobacteria E 3-dehydroquinate synthase (EC 4.6.1.3) - - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_138044_1 1173024.KI912149_gene5690 5.74e-05 50.8 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1JK6C@1189|Stigonemataceae 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_144991_1 207954.MED92_15563 6.76e-56 194.0 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,1XIWR@135619|Oceanospirillales 135619|Oceanospirillales KLT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Pkinase k59_144991_2 203122.Sde_3061 1.48e-41 162.0 COG0726@1|root,COG0726@2|Bacteria,1R7W4@1224|Proteobacteria,1RXZE@1236|Gammaproteobacteria,468DS@72275|Alteromonadaceae 1236|Gammaproteobacteria G Polysaccharide deacetylase xyn11B - - - - - - - - - - - CBM60,CBM_10,CBM_5_12_2,Glyco_hydro_11,Malectin,Polysacc_deac_1 k59_144991_3 377629.TERTU_2912 1.1e-23 100.0 COG3119@1|root,COG3119@2|Bacteria,1R70K@1224|Proteobacteria,1T00F@1236|Gammaproteobacteria,2PP25@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_144991_6 59538.XP_005959169.1 2.32e-105 313.0 COG2162@1|root,2RVZB@2759|Eukaryota,39UAW@33154|Opisthokonta,3BMSB@33208|Metazoa,3D4G1@33213|Bilateria,486V2@7711|Chordata,49AFE@7742|Vertebrata 33208|Metazoa I Belongs to the arylamine N-acetyltransferase family nat1 - 2.3.1.5 ko:K00622 ko00232,ko00633,ko00983,ko01100,ko01110,ko01120,ko05204,map00232,map00633,map00983,map01100,map01110,map01120,map05204 - R07940,R08036,R08248,R08250,R11902 RC00004,RC00416,RC00962,RC02961 ko00000,ko00001,ko01000 - - - Acetyltransf_2 k59_144991_7 561175.KB894094_gene1900 4.02e-110 340.0 COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria,4EGGD@85012|Streptosporangiales 201174|Actinobacteria Q Retinal pigment epithelial membrane protein - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_41408_1 56780.SYN_00126 1.23e-126 371.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MR4Y@213462|Syntrophobacterales 28221|Deltaproteobacteria NU Type IV secretion-system coupling protein DNA-binding domain pilT1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_66912_1 1278073.MYSTI_06363 1.72e-10 66.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTY9@29|Myxococcales 28221|Deltaproteobacteria T response regulator - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_93269_1 933262.AXAM01000040_gene1232 4.76e-93 294.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_164176_2 156889.Mmc1_2394 2.75e-17 93.6 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_164176_3 1286106.MPL1_06517 5.4e-22 96.7 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,4616P@72273|Thiotrichales 72273|Thiotrichales Q toluene tolerance - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_164176_5 1163617.SCD_n01169 3.09e-60 196.0 COG2020@1|root,COG2020@2|Bacteria,1PPQV@1224|Proteobacteria,2VR3S@28216|Betaproteobacteria 28216|Betaproteobacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - - k59_164176_6 1049564.TevJSym_ak00530 4.21e-170 497.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1J5FJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0038 Chloride channel protein EriC eriC - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_125656_1 1232410.KI421425_gene1543 4.59e-31 124.0 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_47537_1 1123228.AUIH01000003_gene873 0.000988 41.2 COG1196@1|root,COG1196@2|Bacteria,1QUTY@1224|Proteobacteria,1T351@1236|Gammaproteobacteria,1XHM7@135619|Oceanospirillales 135619|Oceanospirillales D DNA replication and repair protein RecF - - - - - - - - - - - - AAA_29,SbcCD_C k59_47537_3 674977.VMC_00050 7.91e-59 186.0 2AK67@1|root,31AW6@2|Bacteria,1RKU2@1224|Proteobacteria,1S6CF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type VI secretion system (T6SS), amidase effector protein 4 - - - - - - - - - - - - Tae4 k59_47537_6 502025.Hoch_2451 2.89e-33 127.0 COG2173@1|root,COG2173@2|Bacteria,1N3QY@1224|Proteobacteria,42TQ8@68525|delta/epsilon subdivisions,2WNK8@28221|Deltaproteobacteria,2Z1HD@29|Myxococcales 28221|Deltaproteobacteria M Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide ddpX - 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Peptidase_M15 k59_171045_1 641491.DND132_3165 1.22e-17 90.1 COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1Q0K1@1224|Proteobacteria,43EQ6@68525|delta/epsilon subdivisions,2X9KG@28221|Deltaproteobacteria,2MERK@213115|Desulfovibrionales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_1879_1 1317124.DW2_10259 0.0 1504.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2U1PA@28211|Alphaproteobacteria,2XN2P@285107|Thioclava 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdopterin,Molydop_binding k59_1879_2 1121479.AUBS01000013_gene1330 5.44e-184 521.0 COG5557@1|root,COG5557@2|Bacteria,1MWXD@1224|Proteobacteria,2U10H@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Polysulphide reductase, NrfD - - - ko:K08359 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - NrfD k59_1879_3 1121479.AUBS01000013_gene1329 8.54e-130 373.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_7 k59_1879_4 1353528.DT23_15890 1.05e-88 266.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,2XNAA@285107|Thioclava 28211|Alphaproteobacteria K helix_turn_helix, Lux Regulon - - - ko:K11712,ko:K14987 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1879_5 1317124.DW2_10279 2.46e-140 420.0 COG0715@1|root,COG4191@1|root,COG0715@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2XN4X@285107|Thioclava 28211|Alphaproteobacteria PT ABC transporter, phosphonate, periplasmic substrate-binding protein dctS - 2.7.13.3 ko:K11711 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,Phosphonate-bd,dCache_1 k59_28144_1 1125863.JAFN01000001_gene613 7.7e-149 434.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WKK3@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM UDP-glucose GDP-mannose dehydrogenase - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_139651_2 933262.AXAM01000002_gene543 1.78e-75 237.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TraB family protein - - - - - - - - - - - - TraB k59_152878_1 243276.TPANIC_0519 1.57e-43 158.0 COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes 203691|Spirochaetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains rrp-2 - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_152878_2 1123371.ATXH01000005_gene2083 7.69e-60 189.0 COG1246@1|root,COG1246@2|Bacteria,2GHN0@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Acetyltransferase (GNAT) domain - - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_107681_1 1001240.GY21_21090 1.17e-86 279.0 COG3666@1|root,COG3666@2|Bacteria,2IA0I@201174|Actinobacteria,4FRT9@85023|Microbacteriaceae 201174|Actinobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_121147_1 335543.Sfum_3098 3.23e-135 394.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria,2MQ7K@213462|Syntrophobacterales 28221|Deltaproteobacteria E Amino-transferase class IV ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_2853 Aminotran_4 k59_74763_1 96561.Dole_2746 6.84e-11 62.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_23512_2 391600.ABRU01000041_gene2525 7.3e-55 173.0 2BI4W@1|root,32CA3@2|Bacteria,1RHWB@1224|Proteobacteria,2UD2Y@28211|Alphaproteobacteria,2KIVF@204458|Caulobacterales 204458|Caulobacterales S Killing trait - - - - - - - - - - - - RebB k59_159551_1 649754.HMPREF0281_00223 5.65e-26 111.0 COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,22JT2@1653|Corynebacteriaceae 201174|Actinobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_49306_1 1121459.AQXE01000004_gene1833 9.05e-06 48.5 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,2MGDA@213115|Desulfovibrionales 28221|Deltaproteobacteria GM PFAM Polysaccharide biosynthesis protein - - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 k59_113971_1 335543.Sfum_0711 5.28e-94 291.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2MQFU@213462|Syntrophobacterales 28221|Deltaproteobacteria H Elongator protein 3, MiaB family, Radical SAM kamA2 - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_68911_1 56780.SYN_00309 3.73e-128 377.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MQ8D@213462|Syntrophobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_133725_1 768671.ThimaDRAFT_4306 2.32e-69 229.0 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1WW1W@135613|Chromatiales 135613|Chromatiales CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_204717_2 865938.Weevi_0272 1.36e-44 160.0 2DNQJ@1|root,32YKF@2|Bacteria,4PIY6@976|Bacteroidetes,1IAFC@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_100914_1 525897.Dbac_1841 1.43e-100 301.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_159807_1 1049564.TevJSym_av00270 3.48e-198 573.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1J539@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. prsK - - - - - - - - - - - GAF_2,HATPase_c k59_153066_1 639282.DEFDS_1850 7.33e-93 286.0 COG1509@1|root,COG1509@2|Bacteria,2GFKK@200930|Deferribacteres 200930|Deferribacteres E Radical SAM superfamily - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - LAM_C,Radical_SAM k59_3522_1 398767.Glov_0560 2.3e-41 157.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_204857_1 196367.JNFG01000073_gene6229 7.23e-194 550.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1KH1R@119060|Burkholderiaceae 28216|Betaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_55441_1 1049564.TevJSym_am00210 1e-172 486.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1J4KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_43952_2 192952.MM_3053 1.04e-29 128.0 COG1541@1|root,arCOG02624@2157|Archaea,2XY74@28890|Euryarchaeota,2NAJN@224756|Methanomicrobia 224756|Methanomicrobia H COG1541 Coenzyme F390 synthetase - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_3526_1 1392838.AWNM01000025_gene4198 2.39e-28 115.0 COG3598@1|root,COG3598@2|Bacteria,1QVDX@1224|Proteobacteria,2WHTG@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25 k59_3526_2 1122201.AUAZ01000004_gene3438 7.67e-34 122.0 28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,1RSHA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_69173_2 1219080.VEZ01S_07_00210 1.05e-17 83.2 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1XTCK@135623|Vibrionales 135623|Vibrionales S metal-binding, possibly nucleic acid-binding protein yceD - - ko:K07040 - - - - ko00000 - - - DUF177 k59_43955_1 240292.Ava_1611 6.75e-40 154.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales 1117|Cyanobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_49510_1 1304888.ATWF01000001_gene1742 1.15e-43 155.0 COG1237@1|root,COG1237@2|Bacteria,2GGDF@200930|Deferribacteres 200930|Deferribacteres S beta-lactamase domain protein - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - - k59_29978_2 340177.Cag_1577 2.44e-43 142.0 COG2026@1|root,COG2026@2|Bacteria 2|Bacteria DJ nuclease activity - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE-like_toxin k59_29978_3 1348657.M622_11610 2.44e-34 119.0 2DAFR@1|root,32TVC@2|Bacteria,1R3F7@1224|Proteobacteria,2WIHA@28216|Betaproteobacteria 28216|Betaproteobacteria S ParD-like antitoxin of type II bacterial toxin-antitoxin system - - - - - - - - - - - - ParD_like k59_69175_1 768671.ThimaDRAFT_4530 6.61e-154 442.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,1TKAD@1236|Gammaproteobacteria,1X15X@135613|Chromatiales 135613|Chromatiales L PFAM transposase, IS4 family protein - - - - - - - - - - - - - k59_114164_1 933262.AXAM01000058_gene3204 9.59e-62 215.0 COG0764@1|root,COG3321@1|root,COG0764@2|Bacteria,COG3321@2|Bacteria,1QUWM@1224|Proteobacteria,43BRB@68525|delta/epsilon subdivisions,2WJJ6@28221|Deltaproteobacteria,2MI1Q@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - - - - - - - - - - - Acyl_transf_1,Acyltransferase,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_43957_1 690850.Desaf_1237 5.28e-48 175.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42NNX@68525|delta/epsilon subdivisions,2WJ9P@28221|Deltaproteobacteria,2MD1V@213115|Desulfovibrionales 28221|Deltaproteobacteria U AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22 k59_179299_1 316055.RPE_0751 2.93e-148 421.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,3JXJ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Protocatechuate 4,5-dioxygenase ligB - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_153076_2 768671.ThimaDRAFT_3386 1.09e-64 211.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria,1WX9T@135613|Chromatiales 135613|Chromatiales O smart pdz dhr glgf - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_192042_1 96561.Dole_2029 1.61e-66 216.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MI7I@213118|Desulfobacterales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_69176_1 1479237.JMLY01000001_gene3368 4.61e-58 187.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria,466H0@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0247 Fe-S oxidoreductase lldE - - ko:K18928 - - - - ko00000 - - - CCG k59_133945_1 493475.GARC_2613 4.84e-96 287.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,46869@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_29982_1 1049564.TevJSym_ae00390 1.63e-65 216.0 2EX2V@1|root,33QDY@2|Bacteria,1NQZX@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_204861_1 203122.Sde_3612 5.78e-202 595.0 COG3507@1|root,COG3693@1|root,COG5297@1|root,COG3507@2|Bacteria,COG3693@2|Bacteria,COG5297@2|Bacteria,1R7BZ@1224|Proteobacteria,1S17S@1236|Gammaproteobacteria,466TT@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 10 - - - - - - - - - - - - CBM_2,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_43 k59_204861_2 859657.RPSI07_mp0730 7.01e-129 375.0 COG4757@1|root,COG4757@2|Bacteria,1Q1V6@1224|Proteobacteria,2VKQ9@28216|Betaproteobacteria,1K58F@119060|Burkholderiaceae 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_186110_2 1469245.JFBG01000038_gene1816 2.34e-28 115.0 2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,1SDPA@1236|Gammaproteobacteria,1X1PN@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3306) - - - - - - - - - - - - DUF3306 k59_186110_5 998674.ATTE01000001_gene1788 1.49e-74 233.0 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,1RYH6@1236|Gammaproteobacteria,45ZY6@72273|Thiotrichales 72273|Thiotrichales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_75000_1 56780.SYN_00683 2e-62 198.0 COG0346@1|root,COG0346@2|Bacteria,1Q268@1224|Proteobacteria,437T7@68525|delta/epsilon subdivisions,2X32F@28221|Deltaproteobacteria,2MRN9@213462|Syntrophobacterales 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_146762_1 96561.Dole_1994 1.21e-32 131.0 COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,43DXZ@68525|delta/epsilon subdivisions,2X72D@28221|Deltaproteobacteria,2MNHJ@213118|Desulfobacterales 28221|Deltaproteobacteria E alginic acid biosynthetic process - - - - - - - - - - - - DUF1573 k59_107930_1 1304885.AUEY01000085_gene2477 9.86e-73 236.0 COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2MIER@213118|Desulfobacterales 28221|Deltaproteobacteria S ABC transporter - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_69186_1 1121405.dsmv_3676 1.92e-98 294.0 COG1456@1|root,COG1456@2|Bacteria,1R9BV@1224|Proteobacteria,42P65@68525|delta/epsilon subdivisions,2WMGX@28221|Deltaproteobacteria,2MHNZ@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786,FeS k59_55465_1 706587.Desti_1112 8.52e-109 320.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 k59_55465_2 706587.Desti_4373 6.61e-39 142.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2MQRK@213462|Syntrophobacterales 28221|Deltaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah k59_10774_2 1049564.TevJSym_ba00340 4.3e-27 99.8 COG3197@1|root,COG3197@2|Bacteria 2|Bacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS k59_49527_2 631362.Thi970DRAFT_04840 2.73e-105 326.0 COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,1RQ7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_133947_1 713586.KB900536_gene1333 4.83e-24 99.0 2EQTE@1|root,33ID4@2|Bacteria,1RKB7@1224|Proteobacteria,1S6DN@1236|Gammaproteobacteria,1WYKP@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_16553_1 1056820.KB900638_gene66 1.34e-25 106.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_16553_2 205922.Pfl01_3179 5.78e-09 58.5 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1YQUB@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria U General secretion pathway protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_23756_2 1120968.AUBX01000015_gene3858 8.67e-17 82.4 COG0500@1|root,COG2226@2|Bacteria,4NYCJ@976|Bacteroidetes,47U3P@768503|Cytophagia 976|Bacteroidetes Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_192056_1 335283.Neut_0847 7.11e-24 94.0 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,373F9@32003|Nitrosomonadales 28216|Betaproteobacteria P divalent ion tolerance protein cutA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 - ko:K03926 - - - - ko00000 - - - CutA1 k59_192056_2 1049564.TevJSym_cb00050 2.18e-28 114.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_139896_1 1049564.TevJSym_ac02110 4.52e-58 182.0 28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,1SEW0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_139896_2 1049564.TevJSym_aj00720 1.28e-110 326.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1J5CA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroG GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_0684,iECSF_1327.ECSF_0680,iEcSMS35_1347.EcSMS35_0777,iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335,iYL1228.KPN_00758 DAHP_synth_1 k59_75011_1 713586.KB900536_gene2802 8.7e-56 186.0 COG0265@1|root,COG0265@2|Bacteria,1R6MU@1224|Proteobacteria,1S181@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Trypsin-like serine protease - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_198091_1 396588.Tgr7_0487 5.75e-139 409.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_10781_1 870187.Thini_4271 1.37e-20 90.5 COG1802@1|root,COG1802@2|Bacteria,1Q85H@1224|Proteobacteria,1RZ0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional - - - ko:K15735 - - - - ko00000,ko03000 - - - FCD,GntR k59_107942_1 1499967.BAYZ01000095_gene4075 7.43e-69 214.0 COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria 2|Bacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_165923_2 1049564.TevJSym_aq00590 2.53e-44 153.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1J4QG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_204878_1 1218076.BAYB01000012_gene2601 7.72e-52 168.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VSUJ@28216|Betaproteobacteria,1K73J@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM globin yjbI - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_133952_1 999141.GME_02545 2.31e-31 116.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XIT9@135619|Oceanospirillales 135619|Oceanospirillales E phosphoserine phosphatase - - - - - - - - - - - - HAD k59_121669_1 156889.Mmc1_0540 7.5e-42 156.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TWVC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_103179_1 4432.XP_010248968.1 4.24e-08 59.7 COG0464@1|root,KOG0737@2759|Eukaryota,37IUV@33090|Viridiplantae,3G8DY@35493|Streptophyta 35493|Streptophyta O AAA-type ATPase family protein - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464 - - - - - - - - - - AAA,FHA k59_32350_1 768671.ThimaDRAFT_1486 7.76e-90 293.0 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,1RPPH@1236|Gammaproteobacteria,1WY5F@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_57648_2 706587.Desti_3128 5.8e-17 79.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,42RJ4@68525|delta/epsilon subdivisions,2WNQ3@28221|Deltaproteobacteria,2MQI3@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD,adh_short k59_90739_1 1279015.KB908459_gene2766 6.44e-18 77.8 COG4568@1|root,COG4568@2|Bacteria,1N82G@1224|Proteobacteria,1SCJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional antiterminator - - - ko:K19000 - - - - ko00000,ko03021 - - - ROF k59_168256_1 1121396.KB892990_gene4474 1.63e-39 142.0 COG0589@1|root,COG0589@2|Bacteria,1N6DC@1224|Proteobacteria,42UXA@68525|delta/epsilon subdivisions,2WQF5@28221|Deltaproteobacteria,2MNK3@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_155428_1 706587.Desti_2000 1e-43 154.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,42T4B@68525|delta/epsilon subdivisions,2WPI9@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_155429_1 177437.HRM2_11850 1.14e-54 193.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_6,Pyr_redox_2 k59_77444_1 1249627.D779_0831 2.37e-147 435.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_90741_1 264462.Bd2691 1.34e-06 55.1 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,42QZY@68525|delta/epsilon subdivisions,2MTK8@213481|Bdellovibrionales,2WMN5@28221|Deltaproteobacteria 213481|Bdellovibrionales I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_32361_1 37659.JNLN01000001_gene1416 4.46e-92 297.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_181453_1 1121441.AUCX01000022_gene787 2.52e-76 257.0 COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2M8ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,PA,Peptidase_M28 k59_206948_1 1123368.AUIS01000013_gene852 3.07e-161 470.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,2NCB0@225057|Acidithiobacillales 1236|Gammaproteobacteria G Protein of unknown function (DUF3417) - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_155438_1 96561.Dole_3250 1.8e-126 376.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_200288_1 177437.HRM2_38110 1.68e-42 152.0 COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42RRV@68525|delta/epsilon subdivisions,2WNKH@28221|Deltaproteobacteria,2MJB4@213118|Desulfobacterales 28221|Deltaproteobacteria P Natural resistance-associated macrophage protein - - - - - - - - - - - - Nramp k59_19030_1 439235.Dalk_2648 4.12e-124 360.0 COG0694@1|root,COG0822@1|root,COG1251@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,COG1251@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MIAE@213118|Desulfobacterales 28221|Deltaproteobacteria C May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins nifU - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_26208_1 1049564.TevJSym_bj00170 1.33e-79 253.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1J4FJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0018995,GO:0022610,GO:0030430,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0050789,GO:0051082,GO:0051704,GO:0061077,GO:0065007,GO:0101031,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_110456_1 1049564.TevJSym_af00830 1.96e-47 156.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1JAR6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I CDP-alcohol phosphatidyltransferase pgsA2 - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_110456_2 1049564.TevJSym_af00840 2.06e-109 332.0 COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1J69V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria VV2512 - - ko:K09938 - - - - ko00000 - - - DUF2066 k59_110456_4 765910.MARPU_07890 1.63e-91 275.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales 135613|Chromatiales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_6749_1 1121440.AUMA01000008_gene1038 1.01e-46 151.0 COG1343@1|root,COG1343@2|Bacteria,1MZ9Q@1224|Proteobacteria,42UMG@68525|delta/epsilon subdivisions,2WQ4N@28221|Deltaproteobacteria,2MCEY@213115|Desulfovibrionales 28221|Deltaproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k59_6749_2 1049564.TevJSym_bl00020 1.98e-144 417.0 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,1RNYK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_103937_1 1049564.TevJSym_ag00870 3.61e-53 175.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,1RQT5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_201260_1 1454004.AW11_01265 2.45e-15 76.6 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,2VPFR@28216|Betaproteobacteria 28216|Betaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS k59_52122_1 697281.Mahau_1533 1.15e-15 79.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,42F4Y@68295|Thermoanaerobacterales 186801|Clostridia G PFAM glycoside hydrolase family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C k59_304_1 203122.Sde_0425 2.37e-20 98.2 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,4651Y@72275|Alteromonadaceae 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_39112_2 425104.Ssed_1393 1.16e-33 119.0 COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,1SCHB@1236|Gammaproteobacteria,2QE0F@267890|Shewanellaceae 1236|Gammaproteobacteria P Na+/H+ antiporter subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_84515_2 933262.AXAM01000008_gene1932 1.11e-22 97.8 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MIIC@213118|Desulfobacterales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_155835_1 265729.GS18_0220890 2.29e-59 198.0 COG0583@1|root,COG0583@2|Bacteria,1U05Q@1239|Firmicutes,4HDZS@91061|Bacilli,1ZF2P@1386|Bacillus 91061|Bacilli K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_155835_2 1382306.JNIM01000001_gene2446 4.26e-81 248.0 COG0693@1|root,COG0693@2|Bacteria 2|Bacteria S protein deglycation - - - - - - - - - - - - DJ-1_PfpI k59_155835_4 1121352.JHZP01000001_gene536 1.18e-33 132.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,2KPKW@206351|Neisseriales 206351|Neisseriales S ABC transporter, ATP-binding protein abcZ - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_175268_2 1454004.AW11_01229 1.04e-14 69.3 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria 28216|Betaproteobacteria T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814,ko:K13815 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko02022 - - - HD,HD_5,Response_reg k59_201262_1 706587.Desti_3271 4.45e-11 67.4 COG0784@1|root,COG3290@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_201262_2 572477.Alvin_2673 6.6e-06 46.6 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RZY6@1236|Gammaproteobacteria,1WX9M@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_188232_1 1265505.ATUG01000002_gene1613 1.19e-113 354.0 COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43CWU@68525|delta/epsilon subdivisions 1224|Proteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_181744_1 377629.TERTU_2913 1.46e-50 188.0 COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1QT76@1224|Proteobacteria,1RWVM@1236|Gammaproteobacteria,2PQBZ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Protein of unknown function (DUF1595) - - - - - - - - - - - - Cytochrome_CBB3,PSCyt3,PSD3,PSD4,PSD5 k59_142831_1 335543.Sfum_1371 1.33e-88 271.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_91049_2 247490.KSU1_C1409 3.3e-31 122.0 COG1216@1|root,COG1216@2|Bacteria,2J0X8@203682|Planctomycetes 203682|Planctomycetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_13224_2 1042156.CXIVA_22580 1.33e-37 138.0 COG0685@1|root,COG0685@2|Bacteria,1USZE@1239|Firmicutes,250HQ@186801|Clostridia 186801|Clostridia C Methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_188236_1 941449.dsx2_2172 1.23e-83 253.0 COG0500@1|root,COG2226@2|Bacteria,1RKJ7@1224|Proteobacteria,42T77@68525|delta/epsilon subdivisions,2WT2E@28221|Deltaproteobacteria,2M8S2@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_142835_1 1121935.AQXX01000096_gene2562 6.35e-47 162.0 COG0745@1|root,COG0745@2|Bacteria,1QZ0B@1224|Proteobacteria 1224|Proteobacteria KT RESPONSE REGULATOR receiver - - - - - - - - - - - - - k59_142835_2 1051646.VITU9109_10267 2.33e-34 130.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,1T1YN@1236|Gammaproteobacteria,1Y32Z@135623|Vibrionales 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_103944_1 1268240.ATFI01000001_gene3325 1.01e-08 68.9 COG3209@1|root,COG3209@2|Bacteria,4NGJF@976|Bacteroidetes,2FQPQ@200643|Bacteroidia,4AQCJ@815|Bacteroidaceae 976|Bacteroidetes M RHS repeat-associated core domain protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_45615_1 743722.Sph21_4881 1.03e-57 201.0 COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria,4PMAT@976|Bacteroidetes,1J0HR@117747|Sphingobacteriia 976|Bacteroidetes K Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,GAF_3,HTH_8,PAS_9,Response_reg,Sigma54_activat k59_162344_1 1123514.KB905900_gene2142 3.98e-55 185.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,4607K@72273|Thiotrichales 72273|Thiotrichales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_162344_2 1249627.D779_3648 3.04e-134 390.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWJJ@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_162344_4 765913.ThidrDRAFT_4525 6.33e-57 186.0 COG1309@1|root,COG1309@2|Bacteria,1PE6J@1224|Proteobacteria,1TAD2@1236|Gammaproteobacteria,1WZQ8@135613|Chromatiales 135613|Chromatiales K regulatory protein TetR - - - ko:K09017 - - - - ko00000,ko03000 - - - TetR_N k59_162344_5 686340.Metal_2043 5.96e-67 205.0 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,1SAZP@1236|Gammaproteobacteria,1XF5U@135618|Methylococcales 135618|Methylococcales P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_162344_6 1283300.ATXB01000001_gene915 1.37e-32 122.0 COG3091@1|root,COG3091@2|Bacteria,1N07A@1224|Proteobacteria,1S9E8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the SprT family sprT - - ko:K02742 - - - - ko00000 - - - SprT-like,Zn_ribbon_SprT k59_162344_7 765911.Thivi_4563 6.62e-35 123.0 COG2920@1|root,COG2920@2|Bacteria,1N6BZ@1224|Proteobacteria,1S8YA@1236|Gammaproteobacteria,1WYWH@135613|Chromatiales 135613|Chromatiales P TIGRFAM sulfur relay protein, TusE DsrC DsvC family - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_162344_8 1049564.TevJSym_ad00320 1.4e-105 309.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1J610@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Riboflavin synthase ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c19160,iECP_1309.ECP_1609,ic_1306.c2056 Lum_binding k59_162344_9 56780.SYN_01236 3.08e-14 82.4 COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,1MU9B@1224|Proteobacteria,42N1S@68525|delta/epsilon subdivisions,2WK7R@28221|Deltaproteobacteria,2MRRQ@213462|Syntrophobacterales 28221|Deltaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). mcp40H-21 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1 k59_162344_10 765913.ThidrDRAFT_0267 1.81e-06 54.3 2BVKV@1|root,33EWZ@2|Bacteria,1NNBF@1224|Proteobacteria,1SUDR@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_162344_11 1121939.L861_04980 1.6e-86 263.0 COG1802@1|root,COG1802@2|Bacteria,1R90Y@1224|Proteobacteria,1SYK8@1236|Gammaproteobacteria,1XRJ5@135619|Oceanospirillales 135619|Oceanospirillales K AsnC family transcriptional regulator - - - - - - - - - - - - FCD,GntR k59_65064_2 1248232.BANQ01000155_gene4186 1.65e-25 108.0 2E2S0@1|root,32XUC@2|Bacteria,1N3J9@1224|Proteobacteria,1SEDM@1236|Gammaproteobacteria,1XYSJ@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_65064_3 335543.Sfum_3487 1.09e-133 400.0 COG2885@1|root,COG3221@1|root,COG2885@2|Bacteria,COG3221@2|Bacteria,1R687@1224|Proteobacteria,42ZCB@68525|delta/epsilon subdivisions,2WTSU@28221|Deltaproteobacteria 28221|Deltaproteobacteria MP NMT1/THI5 like - - - - - - - - - - - - NMT1,OmpA k59_103947_1 177439.DP3011 1.15e-70 230.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,2MI6K@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_39117_1 56780.SYN_00640 1.21e-60 201.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_13236_1 177437.HRM2_15110 1.51e-84 262.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria,2MJRK@213118|Desulfobacterales 28221|Deltaproteobacteria C cytochrome c oxidase ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_6755_3 99598.Cal7507_4317 5e-17 84.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HIE5@1161|Nostocales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_78170_1 879212.DespoDRAFT_02180 4.96e-145 431.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_58646_1 153948.NAL212_1363 2.58e-63 206.0 COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,2WFCR@28216|Betaproteobacteria 1224|Proteobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_194664_1 981223.AIED01000004_gene2930 1.07e-41 149.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,3NIVB@468|Moraxellaceae 1236|Gammaproteobacteria P Transporter associated domain corC GO:0001897,GO:0001906,GO:0001907,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0009987,GO:0016020,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071944 - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_188247_1 1121448.DGI_1873 1.99e-33 136.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg k59_103959_1 439235.Dalk_0268 2.48e-97 301.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_201268_1 1049564.TevJSym_av00360 6.97e-150 444.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU general secretion pathway protein D xcsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_175278_1 671143.DAMO_2028 1.93e-36 134.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_97513_1 382464.ABSI01000011_gene2957 4.16e-59 197.0 COG1858@1|root,COG1858@2|Bacteria,46TMB@74201|Verrucomicrobia,2IUEH@203494|Verrucomicrobiae 203494|Verrucomicrobiae P Di-haem cytochrome c peroxidase - - - - - - - - - - - - CCP_MauG k59_97513_2 187272.Mlg_0783 1.16e-71 232.0 COG5266@1|root,COG5266@2|Bacteria,1RJHN@1224|Proteobacteria 1224|Proteobacteria P PFAM Nickel transport complex, NikM subunit, transmembrane - - - - - - - - - - - - - k59_97513_3 1121035.AUCH01000023_gene3428 4.07e-172 487.0 COG0348@1|root,COG0348@2|Bacteria,1MY5M@1224|Proteobacteria,2VH7V@28216|Betaproteobacteria,2KXJC@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - - - - - - - - - - FMN_bind,Fer4_10,Fer4_5 k59_97513_4 395494.Galf_2622 3.25e-218 612.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria 28216|Betaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_97513_5 438753.AZC_4433 9.2e-18 97.1 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,2TQSQ@28211|Alphaproteobacteria,3EYHP@335928|Xanthobacteraceae 28211|Alphaproteobacteria P Secretin and TonB N terminus short domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,STN,TonB_dep_Rec k59_32682_1 1049564.TevJSym_al00690 1.57e-154 459.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1J7D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_32682_2 1348657.M622_09700 1.78e-23 98.6 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria,2KVUG@206389|Rhodocyclales 206389|Rhodocyclales NU NYN domain - - - - - - - - - - - - NYN k59_39128_1 1348635.BBJY01000004_gene2948 1.49e-08 62.0 COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1XVA5@135623|Vibrionales 135623|Vibrionales C Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_155853_1 1049564.TevJSym_bq00010 8.02e-128 390.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J4QC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_201276_1 1121403.AUCV01000002_gene644 2.53e-46 167.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,43AXP@68525|delta/epsilon subdivisions,2X6BV@28221|Deltaproteobacteria,2MPWC@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_97516_1 96561.Dole_3250 1.19e-80 253.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_26246_1 1026882.MAMP_02026 1.46e-26 108.0 COG3170@1|root,COG3170@2|Bacteria,1RDXQ@1224|Proteobacteria,1T42I@1236|Gammaproteobacteria,460XW@72273|Thiotrichales 72273|Thiotrichales NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_181767_1 472759.Nhal_2220 4.31e-278 778.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WX1S@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_84547_1 880072.Desac_1633 3.15e-59 193.0 2EG7U@1|root,339ZP@2|Bacteria,1NV8R@1224|Proteobacteria,42ZI2@68525|delta/epsilon subdivisions,2WV0A@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_85617_3 1260251.SPISAL_05935 7.98e-118 370.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales 135613|Chromatiales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_124642_1 1049564.TevJSym_ab00630 7.61e-171 488.0 COG0577@1|root,COG0577@2|Bacteria,1QRYR@1224|Proteobacteria,1S0ZU@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type antimicrobial peptide transport system, permease component tagS - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_124642_2 991905.SL003B_2137 1.81e-138 399.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U2DD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_27344_2 621372.ACIH01000203_gene2412 8.43e-07 51.2 COG1160@1|root,COG1160@2|Bacteria,1UI84@1239|Firmicutes,4HIBG@91061|Bacilli,27782@186822|Paenibacillaceae 91061|Bacilli S Dynamin family - - - - - - - - - - - - MMR_HSR1 k59_163441_1 631362.Thi970DRAFT_00980 8.94e-84 258.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_163441_3 1049564.TevJSym_ai00580 1.56e-32 124.0 29WW8@1|root,30IHW@2|Bacteria,1QXWS@1224|Proteobacteria,1T3ID@1236|Gammaproteobacteria,1J7AN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Type II secretion system protein B - - - ko:K02451 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - T2SSB k59_98403_1 189753.AXAS01000102_gene5975 5.72e-80 249.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_98403_2 1454004.AW11_01881 9.54e-95 284.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria 28216|Betaproteobacteria L RNA-directed DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_14103_1 1121405.dsmv_2068 1.44e-122 374.0 COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions,2X6WX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S AAA-like domain - - - - - - - - - - - - - k59_46707_1 755178.Cyan10605_1378 8.41e-77 239.0 COG1121@1|root,COG1121@2|Bacteria,1G2EJ@1117|Cyanobacteria 1117|Cyanobacteria P ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_137346_1 1232683.ADIMK_0776 2.54e-137 414.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,1T0DP@1236|Gammaproteobacteria,469T2@72275|Alteromonadaceae 1236|Gammaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_150606_2 1121405.dsmv_3233 1.27e-56 184.0 COG1774@1|root,COG1774@2|Bacteria,1MZBX@1224|Proteobacteria,42NE3@68525|delta/epsilon subdivisions,2WK98@28221|Deltaproteobacteria,2MHSJ@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM PSP1 domain protein - - - - - - - - - - - - PSP1 k59_53157_1 1049564.TevJSym_bb00310 3.47e-23 90.5 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity bigR - - ko:K03892,ko:K07721,ko:K22042,ko:K22491 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_53157_2 1049564.TevJSym_bb00320 4.96e-16 72.0 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1SGAM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the SlyX family slyX - - ko:K03745 - - - - ko00000 - - - SlyX k59_66104_1 56780.SYN_01036 1.65e-62 214.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_98405_1 1232437.KL662047_gene5203 6.46e-88 276.0 COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2MJBB@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM DAHP synthetase I - - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,DAHP_synth_1,PDT k59_79460_1 765912.Thimo_1150 3.83e-78 252.0 COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales 135613|Chromatiales P TrkA-C domain - - - - - - - - - - - - CitMHS,TrkA_C k59_156926_4 1177181.T9A_03197 9.11e-08 56.2 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1XIG5@135619|Oceanospirillales 135619|Oceanospirillales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_189499_1 1049564.TevJSym_aq00430 2.27e-64 202.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1J6DN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_40392_1 879212.DespoDRAFT_02213 1.89e-36 134.0 COG3829@1|root,COG3829@2|Bacteria,1R6M8@1224|Proteobacteria,42PRC@68525|delta/epsilon subdivisions,2WMEU@28221|Deltaproteobacteria,2MIN3@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat k59_33850_1 1265505.ATUG01000001_gene3573 6e-113 347.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_144171_1 1122211.JMLW01000017_gene1611 2.41e-05 47.8 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RPQR@1236|Gammaproteobacteria,1XNU2@135619|Oceanospirillales 135619|Oceanospirillales S HipA N-terminal domain - - - - - - - - - - - - Couple_hipA,HipA_C k59_144171_2 561231.Pecwa_0452 7.09e-121 358.0 arCOG14100@1|root,2Z924@2|Bacteria,1R4ME@1224|Proteobacteria,1T6CC@1236|Gammaproteobacteria,1MTDD@122277|Pectobacterium 1236|Gammaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_7901_1 1122207.MUS1_07250 1.51e-82 254.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1XH6T@135619|Oceanospirillales 135619|Oceanospirillales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_46714_1 485915.Dret_1270 2.44e-46 163.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2M8GP@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_66107_1 29495.EA26_18395 5.59e-22 97.1 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XT1B@135623|Vibrionales 135623|Vibrionales CI oxaloacetate oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_66107_2 1049564.TevJSym_bc00090 2.59e-106 317.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1J570@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit oadB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_118216_1 1121405.dsmv_0548 3.54e-53 173.0 2AVTU@1|root,31MME@2|Bacteria,1NQ7V@1224|Proteobacteria,42XCN@68525|delta/epsilon subdivisions,2WTFJ@28221|Deltaproteobacteria,2MNKH@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_137354_1 1333998.M2A_0859 4.9e-84 258.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,4BR9P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome bd terminal oxidase subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_170128_2 529709.PYCH_16190 9.29e-33 130.0 COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci 183968|Thermococci L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - Intein_splicing,LAGLIDADG_3,PolC_DP2 k59_7902_1 28072.Nos7524_3621 3.01e-17 81.3 COG1702@1|root,COG1702@2|Bacteria,1G0U5@1117|Cyanobacteria,1HJ7F@1161|Nostocales 1117|Cyanobacteria T Phosphate starvation-inducible protein PhoH phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_7902_2 932677.PAJ_0459 6.68e-44 149.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,3VXNU@53335|Pantoea 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_20849_1 1049564.TevJSym_an00030 4.4e-188 537.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_33855_1 406817.XNC1_0716 8.59e-64 209.0 COG3039@1|root,COG3039@2|Bacteria,1MXP1@1224|Proteobacteria,1RSBM@1236|Gammaproteobacteria 1236|Gammaproteobacteria L There are 9 addittional ORFs identical to this one - - - - - - - - - - - - DDE_Tnp_1_3 k59_1189_1 1158602.I590_00300 1.65e-06 53.5 COG1476@1|root,COG1476@2|Bacteria,1V2KY@1239|Firmicutes,4HMC3@91061|Bacilli,4B0TK@81852|Enterococcaceae 91061|Bacilli K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_124662_1 335543.Sfum_0439 6.07e-98 294.0 COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,42VTH@68525|delta/epsilon subdivisions,2WS84@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_14113_1 1265505.ATUG01000001_gene4255 1.38e-175 493.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,42QUI@68525|delta/epsilon subdivisions,2WSPS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF1989) - - - - - - - - - - - - DUF1989 k59_20854_1 395493.BegalDRAFT_2164 8.99e-66 214.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_183038_2 392500.Swoo_0681 6.21e-38 135.0 2DZH7@1|root,32VAP@2|Bacteria,1N6FC@1224|Proteobacteria,1SABS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - TerB k59_156940_1 429009.Adeg_1312 9.7e-37 135.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,42EM8@68295|Thermoanaerobacterales 186801|Clostridia T protein phosphatase 2C domain protein prpC - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2,SpoIIE k59_131219_1 1049564.TevJSym_ap00410 1.69e-171 499.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1J4NM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_53170_1 525897.Dbac_3015 2.89e-149 437.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2M9H9@213115|Desulfovibrionales 28221|Deltaproteobacteria H PFAM Carboxylyase-related protein - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_85625_1 1207055.C100_02930 4.07e-87 268.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2K127@204457|Sphingomonadales 204457|Sphingomonadales C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_85625_2 1458357.BG58_09915 6.87e-19 84.0 COG3791@1|root,COG3791@2|Bacteria,1PSHK@1224|Proteobacteria,2WA8H@28216|Betaproteobacteria,1KA4R@119060|Burkholderiaceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_163728_1 187272.Mlg_0233 2.36e-34 125.0 2B5BG@1|root,31Y5N@2|Bacteria,1RJ1N@1224|Proteobacteria,1S56J@1236|Gammaproteobacteria,1WYC6@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_163728_3 1095769.CAHF01000011_gene2398 9.54e-148 428.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,472E5@75682|Oxalobacteraceae 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_21196_3 1049564.TevJSym_ae00110 3.76e-40 139.0 2DN9N@1|root,32UII@2|Bacteria,1MZ4A@1224|Proteobacteria,1SHWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Phage_CP76 k59_79752_1 335543.Sfum_0458 6.43e-300 829.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MR53@213462|Syntrophobacterales 28221|Deltaproteobacteria I PFAM Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_79752_2 1123325.JHUV01000014_gene29 5.37e-88 276.0 COG0012@1|root,COG0012@2|Bacteria,2G3SU@200783|Aquificae 200783|Aquificae J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_53441_2 1121939.L861_16720 7.04e-95 301.0 COG0666@1|root,COG0666@2|Bacteria,1QW9Z@1224|Proteobacteria,1T39X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1835) - - - - - - - - - - - - DUF1835 k59_72878_1 1249627.D779_1971 1.39e-139 410.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales 135613|Chromatiales L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_98677_1 1499685.CCFJ01000057_gene589 4.28e-34 123.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,4HIG2@91061|Bacilli,1ZGI0@1386|Bacillus 91061|Bacilli FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases hit - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_163731_1 663952.SDD27957_08800 3.68e-35 137.0 COG0578@1|root,COG0578@2|Bacteria,1TQJN@1239|Firmicutes,4HAG8@91061|Bacilli,1MA1H@119603|Streptococcus dysgalactiae group 91061|Bacilli C C-terminal domain of alpha-glycerophosphate oxidase glpD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.1.3.21,1.1.5.3 ko:K00105,ko:K00111 ko00564,ko01110,map00564,map01110 - R00846,R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_157219_2 1049564.TevJSym_ae00360 1e-178 520.0 COG2369@1|root,COG2369@2|Bacteria 2|Bacteria K cell adhesion - - - - - - - - - - - - Phage_Mu_F k59_189760_1 1424334.W822_20180 3.75e-46 166.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,2VRP1@28216|Betaproteobacteria,3T1G1@506|Alcaligenaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_14351_3 997350.HMPREF9129_0236 1.77e-37 148.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,22GQG@1570339|Peptoniphilaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_14351_6 1121439.dsat_1526 8.72e-186 528.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,42N7I@68525|delta/epsilon subdivisions,2WKY2@28221|Deltaproteobacteria,2M8MH@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_8142_1 1286106.MPL1_04977 1.07e-60 196.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,460UF@72273|Thiotrichales 72273|Thiotrichales K PFAM Response regulator receiver domain - - - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_98678_1 335543.Sfum_2942 8.56e-21 92.8 COG2358@1|root,COG2358@2|Bacteria,1PK4K@1224|Proteobacteria,42X0K@68525|delta/epsilon subdivisions,2WT1F@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_72882_1 1144888.CM001467_gene110 1.02e-32 123.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,47F8B@766|Rickettsiales 766|Rickettsiales L Winged helix-turn helix - - - - - - - - - - - - HTH_29,rve k59_204207_3 1146883.BLASA_0999 6.66e-36 139.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - PA,PKD k59_204207_4 1114970.PSF113_2574 3.69e-51 177.0 COG2197@1|root,COG2197@2|Bacteria,1QAMX@1224|Proteobacteria 1224|Proteobacteria K PFAM regulatory protein LuxR - - - - - - - - - - - - GerE k59_35978_1 589865.DaAHT2_0221 9.34e-68 223.0 COG2172@1|root,COG2208@1|root,COG5002@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG5002@2|Bacteria,1PGCN@1224|Proteobacteria,42ZJ2@68525|delta/epsilon subdivisions,2WUYN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM Stage II sporulation E family protein - - - - - - - - - - - - SpoIIE k59_15773_1 555500.I215_07087 8.97e-60 191.0 COG5421@1|root,COG5421@2|Bacteria,4PAGJ@976|Bacteroidetes,1IAIH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_42913_2 1123401.JHYQ01000018_gene2328 3.17e-36 129.0 2CG07@1|root,33ZSV@2|Bacteria,1NYDT@1224|Proteobacteria,1SPWB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2452) - - - - - - - - - - - - DUF2452 k59_94795_1 562970.Btus_0422 3.63e-13 75.1 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,4HGTZ@91061|Bacilli 91061|Bacilli P ATPases associated with a variety of cellular activities - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_15774_1 933262.AXAM01000062_gene955 6.95e-94 280.0 COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MJA2@213118|Desulfobacterales 28221|Deltaproteobacteria D PFAM Cobyrinic acid ac-diamide synthase cooC - - ko:K07321 - - - - ko00000 - - - CbiA k59_178614_1 880072.Desac_1440 1.92e-18 80.1 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2WQ8U@28221|Deltaproteobacteria,2MQK7@213462|Syntrophobacterales 28221|Deltaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_178614_2 1304885.AUEY01000001_gene3233 9.61e-55 177.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2WN9B@28221|Deltaproteobacteria,2MIP4@213118|Desulfobacterales 28221|Deltaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_185229_1 388467.A19Y_4547 2.67e-70 233.0 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1G16R@1117|Cyanobacteria,1H85V@1150|Oscillatoriales 1117|Cyanobacteria C belongs to the CobB CobQ family pta - 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB k59_146097_3 5011.R4XM90 8.16e-13 77.0 COG5309@1|root,2QQE6@2759|Eukaryota,38HGU@33154|Opisthokonta,3NW21@4751|Fungi,3QNSF@4890|Ascomycota,3MCWA@451866|Taphrinomycotina 4751|Fungi G Belongs to the glycosyl hydrolase 17 family - GO:0003674,GO:0003824,GO:0004338,GO:0004553,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0008422,GO:0009272,GO:0009277,GO:0009987,GO:0010383,GO:0015926,GO:0016787,GO:0016798,GO:0030312,GO:0034406,GO:0042546,GO:0043170,GO:0044036,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0070879,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:0071944,GO:0071966 3.2.1.39,3.2.1.58 ko:K01199,ko:K01210 ko00500,map00500 - R00308,R03115 RC00467 ko00000,ko00001,ko00537,ko01000 - GH17 - Glyco_hydro_17 k59_146097_5 396588.Tgr7_3081 2.02e-43 150.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,1WXI7@135613|Chromatiales 135613|Chromatiales P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_165260_1 1121405.dsmv_1603 1.67e-29 107.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MKJV@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_165260_2 439235.Dalk_2404 3.81e-45 155.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,2MJ58@213118|Desulfobacterales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_42922_1 177437.HRM2_46500 2.59e-76 245.0 COG0457@1|root,COG1944@1|root,COG0457@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2MHRU@213118|Desulfobacterales 28221|Deltaproteobacteria S YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - TPR_1,TPR_16,TPR_2,TPR_8,YcaO k59_120492_1 266265.Bxe_B0305 4.01e-16 76.6 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1K0R6@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family acoD - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_120492_2 391735.Veis_3513 3.47e-62 193.0 COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,2VSRW@28216|Betaproteobacteria,4AEPF@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF779) - - - ko:K09959 - - - - ko00000 - - - DUF779 k59_120492_3 765910.MARPU_01860 3.03e-47 163.0 COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria,1WVUU@135613|Chromatiales 135613|Chromatiales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_158965_2 1167006.UWK_00034 9.57e-111 329.0 COG3221@1|root,COG3221@2|Bacteria,1QVNP@1224|Proteobacteria,42S28@68525|delta/epsilon subdivisions,2WP33@28221|Deltaproteobacteria,2MN7E@213118|Desulfobacterales 28221|Deltaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - - - - - - - - - - Phosphonate-bd k59_158965_3 1125700.HMPREF9195_00325 1.4e-05 55.8 COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes 203691|Spirochaetes NT methyl-accepting chemotaxis protein mcp2 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_87582_2 933262.AXAM01000053_gene2705 2.27e-54 185.0 COG3233@1|root,COG3233@2|Bacteria,1RB7V@1224|Proteobacteria,42RBC@68525|delta/epsilon subdivisions,2WMQB@28221|Deltaproteobacteria,2MJK1@213118|Desulfobacterales 28221|Deltaproteobacteria S deacetylase - - - - - - - - - - - - - k59_68330_1 292415.Tbd_2590 1.81e-06 45.8 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,1KRV0@119069|Hydrogenophilales 119069|Hydrogenophilales J Ribosomal protein L33 rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_68330_2 765912.Thimo_0119 4.42e-279 785.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_74246_1 439235.Dalk_3288 1.47e-108 340.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MIFX@213118|Desulfobacterales 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_204223_1 1121451.DESAM_23070 3.62e-61 211.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WKC0@28221|Deltaproteobacteria,2M7TX@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K10819 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,PAS_8,PAS_9,sCache_3_2 k59_9964_1 335543.Sfum_1829 2.05e-88 289.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales 28221|Deltaproteobacteria I BadF BadG BcrA BcrD - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_29198_1 485916.Dtox_1234 4.11e-48 163.0 COG1149@1|root,COG1149@2|Bacteria,1TP7Y@1239|Firmicutes,249ER@186801|Clostridia,261JT@186807|Peptococcaceae 186801|Clostridia C Cobyrinic acid ac-diamide synthase - - - - - - - - - - - - CbiA,Fer4 k59_22955_1 765913.ThidrDRAFT_3877 3.41e-23 93.2 COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,1RNUG@1236|Gammaproteobacteria,1WY4E@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - - - - - - - - - - - Oxidored_q6 k59_22955_2 765911.Thivi_2909 4.23e-67 220.0 COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria,1WWJR@135613|Chromatiales 135613|Chromatiales C NADH dehydrogenase - - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_48783_2 1049564.TevJSym_af00690 8.11e-275 770.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria,1J9TP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_87588_1 224325.AF_1306 7.76e-09 59.3 COG2006@1|root,arCOG02447@2157|Archaea,2XWUP@28890|Euryarchaeota,2466A@183980|Archaeoglobi 183980|Archaeoglobi S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_197427_1 1131553.JIBI01000018_gene516 1.81e-162 505.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_16,TonB_dep_Rec k59_178631_1 365044.Pnap_1536 1.92e-14 78.2 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,4A9VC@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_35998_1 933262.AXAM01000013_gene1293 1.26e-32 124.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_35998_2 933262.AXAM01000102_gene1243 1.42e-22 96.7 COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MI8S@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM - - - - - - - - - - - - Radical_SAM k59_68333_2 765912.Thimo_2787 5.35e-153 446.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_100270_1 1235796.C815_00153 5.47e-06 50.8 COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes 1239|Firmicutes F Psort location Cytoplasmic, score cmk - - - - - - - - - - - Cytidylate_kin2 k59_54920_1 1049564.TevJSym_af00900 6.37e-08 55.1 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S2RH@1236|Gammaproteobacteria,1JBJA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - HD_5,Response_reg k59_68336_1 335543.Sfum_0717 3.75e-58 189.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MQYP@213462|Syntrophobacterales 28221|Deltaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_35999_1 1049564.TevJSym_ad01580 6.39e-120 378.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_15790_1 933262.AXAM01000050_gene3482 4.73e-124 373.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2MHTZ@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_139189_1 177437.HRM2_24850 1.45e-18 90.5 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales 28221|Deltaproteobacteria I Phosphate acyltransferases - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Acyltransferase,Hydrolase_4 k59_146119_1 1382306.JNIM01000001_gene1807 2.43e-36 135.0 COG1690@1|root,COG1690@2|Bacteria,2G5NT@200795|Chloroflexi 200795|Chloroflexi S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_146119_2 247490.KSU1_C0336 1.33e-42 152.0 COG1690@1|root,COG1690@2|Bacteria,2IWY4@203682|Planctomycetes 203682|Planctomycetes S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_185252_2 398767.Glov_3660 2.51e-21 89.4 COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria 1224|Proteobacteria P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiM GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_191417_1 1207076.ALAT01000230_gene698 9.53e-17 85.1 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1Z0CT@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_172092_1 106582.XP_004556936.1 1.26e-06 51.6 COG0471@1|root,KOG1281@2759|Eukaryota,38C60@33154|Opisthokonta,3BBN0@33208|Metazoa,3CTA5@33213|Bilateria,4847R@7711|Chordata,4923D@7742|Vertebrata,49QKR@7898|Actinopterygii 33208|Metazoa P Solute carrier family 13 SLC13A5 GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005343,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006842,GO:0006848,GO:0006855,GO:0007275,GO:0007568,GO:0008028,GO:0008150,GO:0008324,GO:0008340,GO:0008509,GO:0008514,GO:0010259,GO:0010883,GO:0010889,GO:0015075,GO:0015077,GO:0015081,GO:0015137,GO:0015141,GO:0015142,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015711,GO:0015718,GO:0015740,GO:0015744,GO:0015746,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016323,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032501,GO:0032502,GO:0032879,GO:0034220,GO:0035674,GO:0035725,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0048856,GO:0050789,GO:0050833,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071422,GO:0071702,GO:0071944,GO:0098590,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1901475,GO:1903825,GO:1905039,GO:1905952 - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_172092_2 396588.Tgr7_0365 2.18e-30 108.0 COG2920@1|root,COG2920@2|Bacteria 2|Bacteria P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_48968_1 933262.AXAM01000101_gene2550 1.06e-22 96.3 COG0711@1|root,COG0711@2|Bacteria,1ND52@1224|Proteobacteria,42V20@68525|delta/epsilon subdivisions,2WRR4@28221|Deltaproteobacteria,2MKYZ@213118|Desulfobacterales 28221|Deltaproteobacteria C ATP synthase B/B' CF(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_23154_1 1236541.BALL01000004_gene713 1.59e-97 293.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,2QAE4@267890|Shewanellaceae 1236|Gammaproteobacteria L Winged helix-turn helix ylbG - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_3074_1 1109445.AGSX01000046_gene3588 0.000105 44.7 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1Z20S@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_68551_2 1229909.NSED_08780 4.91e-09 56.6 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_100471_1 85643.Tmz1t_3142 1.91e-45 163.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2VKHA@28216|Betaproteobacteria,2KUFX@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_10177_1 98439.AJLL01000060_gene955 5.56e-73 244.0 COG2217@1|root,COG2217@2|Bacteria,1G0JR@1117|Cyanobacteria,1JJHG@1189|Stigonemataceae 1117|Cyanobacteria P Heavy-metal-associated domain pacS GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_152539_1 643562.Daes_3246 1.21e-27 105.0 COG2391@1|root,COG2391@2|Bacteria,1N3PQ@1224|Proteobacteria,42URY@68525|delta/epsilon subdivisions,2WQYF@28221|Deltaproteobacteria,2MGG9@213115|Desulfovibrionales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_15980_1 1232437.KL662042_gene1996 1.27e-70 231.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_185473_1 1472716.KBK24_0120640 1.06e-232 689.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,2VJ0M@28216|Betaproteobacteria,1K310@119060|Burkholderiaceae 28216|Betaproteobacteria S type VI secretion protein icmF - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N k59_3076_1 1301098.PKB_1148 1.99e-09 60.1 COG0457@1|root,COG1352@1|root,COG0457@2|Bacteria,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,1S1XK@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT Chemotaxis protein CheR wspC - 2.1.1.80 ko:K00575,ko:K13486 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N,TPR_8 k59_3076_2 1499967.BAYZ01000061_gene5965 2.07e-20 88.6 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis wspD - - ko:K03408,ko:K13486,ko:K13489 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_107335_1 519989.ECTPHS_03076 3.51e-261 743.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_133409_2 670292.JH26_11315 1e-125 405.0 COG1674@1|root,COG4783@1|root,COG1674@2|Bacteria,COG4783@2|Bacteria 2|Bacteria L chaperone-mediated protein folding ftsK - - ko:K02660,ko:K03466,ko:K07474,ko:K19175 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044,ko02048,ko03036 3.A.12 - - FtsK_SpoIIIE,Ftsk_gamma k59_62150_1 926550.CLDAP_12080 2.77e-19 86.3 COG1484@1|root,COG1484@2|Bacteria,2G7YG@200795|Chloroflexi 200795|Chloroflexi L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_68561_1 203907.Bfl331 1.21e-42 158.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,28333@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria C 2-oxoglutarate dehydrogenase sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0030976,GO:0032991,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0046872,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_0677,iYL1228.KPN_00732 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_23157_1 439235.Dalk_2669 4.74e-115 371.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales 28221|Deltaproteobacteria I BadF BadG BcrA BcrD - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_23157_2 880072.Desac_2355 2.2e-12 65.9 COG0826@1|root,COG0826@2|Bacteria,1N4QJ@1224|Proteobacteria,42YJR@68525|delta/epsilon subdivisions,2WUQ1@28221|Deltaproteobacteria,2MR6V@213462|Syntrophobacterales 28221|Deltaproteobacteria O Peptidase family U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_139369_2 1396858.Q666_02815 2.76e-66 204.0 COG0454@1|root,COG0456@2|Bacteria,1RGV2@1224|Proteobacteria,1S8FN@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_152541_1 1499967.BAYZ01000009_gene5391 4.9e-153 455.0 COG2766@1|root,COG2766@2|Bacteria 2|Bacteria T protein kinase activity - - - - - - - - - - - - AAA_PrkA,PrkA k59_120759_2 1049564.TevJSym_au00650 1.56e-36 124.0 2E5UC@1|root,330IN@2|Bacteria,1NAMZ@1224|Proteobacteria,1SCK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cbb3-type cytochrome oxidase component FixQ - - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_185478_2 1042377.AFPJ01000023_gene660 2.94e-23 96.3 COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria,46BMC@72275|Alteromonadaceae 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_178793_1 570417.WP0338 2.87e-26 111.0 COG3344@1|root,COG3344@2|Bacteria,1NB7T@1224|Proteobacteria,2UU48@28211|Alphaproteobacteria,47GDS@766|Rickettsiales 766|Rickettsiales L reverse transcriptase - - - - - - - - - - - - - k59_197598_1 1230476.C207_00518 0.000553 48.9 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - BTAD,Guanylate_cyc,Trans_reg_C k59_191610_2 1408424.JHYI01000023_gene4257 1.59e-39 139.0 COG0406@1|root,COG0406@2|Bacteria,1VBE0@1239|Firmicutes,4HJR9@91061|Bacilli,1ZGF2@1386|Bacillus 91061|Bacilli G Histidine phosphatase superfamily (branch 1) - - - - - - - - - - - - His_Phos_1 k59_100485_1 1265505.ATUG01000003_gene52 1.42e-58 189.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria,2MIMI@213118|Desulfobacterales 28221|Deltaproteobacteria I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_70655_1 1238182.C882_3877 8.84e-40 143.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2JPGN@204441|Rhodospirillales 204441|Rhodospirillales S MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_89425_1 1169143.KB911035_gene2327 3.74e-43 153.0 COG0300@1|root,COG0300@2|Bacteria,1R3VU@1224|Proteobacteria,2VN1U@28216|Betaproteobacteria,1K492@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_89425_2 1173020.Cha6605_5607 7.03e-23 97.1 COG1309@1|root,COG1309@2|Bacteria,1G6VD@1117|Cyanobacteria 1117|Cyanobacteria K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_4599_1 880072.Desac_1515 5.42e-35 124.0 COG1839@1|root,COG1839@2|Bacteria,1RBCB@1224|Proteobacteria,42S44@68525|delta/epsilon subdivisions,2WMAS@28221|Deltaproteobacteria,2MQHJ@213462|Syntrophobacterales 28221|Deltaproteobacteria S Adenosine specific kinase - - - ko:K09129 - - - - ko00000 - - - Adenosine_kin k59_4599_2 1479239.JQMU01000001_gene2441 4.77e-13 69.3 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2K0D0@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_129217_3 2340.JV46_15700 3.15e-52 184.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_199237_1 1232437.KL662006_gene4464 1.99e-49 171.0 COG0635@1|root,COG0635@2|Bacteria,1R030@1224|Proteobacteria,43CQ4@68525|delta/epsilon subdivisions,2X7XD@28221|Deltaproteobacteria,2MPNT@213118|Desulfobacterales 28221|Deltaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_50705_1 1049564.TevJSym_ad01520 8.21e-224 637.0 COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,1RNYP@1236|Gammaproteobacteria,1J59Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T response regulator - - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_115356_1 523791.Kkor_1251 8.66e-74 225.0 2FG9C@1|root,3485Q@2|Bacteria,1P3SX@1224|Proteobacteria,1SS96@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_115356_2 187272.Mlg_0386 1.77e-43 152.0 2C87N@1|root,2ZCQ2@2|Bacteria,1RBNP@1224|Proteobacteria,1S2KA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3800) - - - - - - - - - - - - DUF3800 k59_205933_1 335543.Sfum_1682 9.59e-43 143.0 COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MRPV@213462|Syntrophobacterales 28221|Deltaproteobacteria S ACT domain - - - - - - - - - - - - ACT k59_160988_1 472759.Nhal_3902 3.33e-107 315.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC k59_160988_2 1049564.TevJSym_am00060 1.9e-131 387.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_187362_1 1441629.PCH70_12110 3.99e-60 204.0 COG0643@1|root,COG2199@1|root,COG0643@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S1A7@1236|Gammaproteobacteria,1Z7DX@136849|Pseudomonas syringae group 1236|Gammaproteobacteria T diguanylate cyclase wspR - 2.7.7.65,3.1.3.3 ko:K07315,ko:K11444 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko03021 - - - GGDEF,Response_reg k59_173268_1 1461579.CCNK01000027_gene769 1.03e-27 109.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1Y77Q@135625|Pasteurellales 135625|Pasteurellales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_173268_2 1232410.KI421424_gene1698 9.1e-55 185.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_76186_1 290512.Paes_2241 3.86e-05 45.4 2DIMZ@1|root,303P5@2|Bacteria,1FFN9@1090|Chlorobi 1090|Chlorobi S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_115357_1 1232437.KL661969_gene4958 5.23e-76 252.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase zraS - 2.7.13.3 ko:K02668,ko:K07709,ko:K07710 ko02020,map02020 M00499,M00500,M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_3_2 k59_50712_1 1004785.AMBLS11_12415 1.36e-45 164.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,1RNBP@1236|Gammaproteobacteria,469EH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_102137_4 572477.Alvin_2273 3.59e-06 55.5 2C097@1|root,2ZB9D@2|Bacteria,1R9DD@1224|Proteobacteria,1S083@1236|Gammaproteobacteria,1WXQR@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_160993_1 29908.U7PSY7 4.9e-05 45.1 COG1225@1|root,2SC9F@2759|Eukaryota,3A2X5@33154|Opisthokonta,3P3J2@4751|Fungi,3QVZP@4890|Ascomycota,21A95@147550|Sordariomycetes 4751|Fungi O Redoxin - - - - - - - - - - - - AhpC-TSA k59_160993_2 706587.Desti_1769 1.77e-31 116.0 COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,42SCA@68525|delta/epsilon subdivisions,2WP2G@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_56443_1 1049564.TevJSym_af01070 9.96e-209 594.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1J4VI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_141249_1 1280698.AUJS01000083_gene3070 6.99e-40 148.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia 186801|Clostridia L Reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_167168_1 344747.PM8797T_27954 2.68e-44 159.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66 k59_12011_1 1121396.KB892913_gene162 1.32e-07 58.5 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MR8@68525|delta/epsilon subdivisions,2WIUA@28221|Deltaproteobacteria,2MPS8@213118|Desulfobacterales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_129222_1 28258.KP05_08250 1.63e-98 299.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XIK3@135619|Oceanospirillales 135619|Oceanospirillales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_154146_1 443144.GM21_4137 3.05e-27 118.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PP9@68525|delta/epsilon subdivisions,2WMFX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Radical SAM superfamily - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_102151_2 177437.HRM2_37640 2.43e-55 184.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_122876_1 933262.AXAM01000053_gene2713 1.95e-95 298.0 COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales 28221|Deltaproteobacteria CI Conserved carboxylase domain - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_154152_1 1379281.AVAG01000032_gene119 4.08e-102 312.0 COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_135037_1 1265505.ATUG01000003_gene341 3.61e-61 191.0 COG1908@1|root,COG1908@2|Bacteria,1RGF7@1224|Proteobacteria,42S3H@68525|delta/epsilon subdivisions,2WNTN@28221|Deltaproteobacteria,2MKRI@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_135037_2 1232437.KL662038_gene2288 3.07e-21 88.6 COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria,2MHNS@213118|Desulfobacterales 28221|Deltaproteobacteria C Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_147965_1 335283.Neut_2531 4.92e-43 147.0 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,3737H@32003|Nitrosomonadales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF882) - - - - - - - - - - - - Peptidase_M15_2 k59_89434_1 96561.Dole_0477 3.86e-58 185.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2MJ2A@213118|Desulfobacterales 28221|Deltaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_89434_2 1232410.KI421418_gene2263 1.36e-106 317.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,43SW0@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_187377_1 105559.Nwat_0320 1.46e-60 197.0 2C6TB@1|root,32RHR@2|Bacteria,1RKX5@1224|Proteobacteria,1SPS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_187377_2 1349767.GJA_2209 6.79e-164 474.0 28JJ9@1|root,2Z9CC@2|Bacteria,1R4HT@1224|Proteobacteria,2VNXY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_187377_3 316067.Geob_2224 5.77e-170 497.0 28HPE@1|root,2Z7XE@2|Bacteria,1PV34@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_50730_1 1049564.TevJSym_ak00680 2.16e-207 585.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_17672_1 2340.JV46_27850 1.21e-31 117.0 COG0517@1|root,COG0517@2|Bacteria,1NJC6@1224|Proteobacteria,1SV2H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_115374_1 1198232.CYCME_1289 1.37e-16 80.9 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,461WR@72273|Thiotrichales 72273|Thiotrichales P Iron permease FTR1 family - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 k59_161011_1 472759.Nhal_2108 1.43e-159 459.0 COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,1RRBP@1236|Gammaproteobacteria,1WWV4@135613|Chromatiales 135613|Chromatiales C PFAM Glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_205971_1 1463853.JOHW01000018_gene5022 4.46e-18 97.1 COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria 201174|Actinobacteria M TIGRFAM YD repeat protein - - - - - - - - - - - - PT-HINT,RHS_repeat,Ricin_B_lectin,SCP1201-deam k59_12022_1 983545.Glaag_3179 1.5e-38 132.0 COG3789@1|root,COG3789@2|Bacteria,1RDFN@1224|Proteobacteria,1S565@1236|Gammaproteobacteria,46704@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2170) - - - ko:K09980 - - - - ko00000 - - - DUF2170 k59_12022_2 349521.HCH_06597 3.79e-78 239.0 COG1842@1|root,COG1842@2|Bacteria,1R41V@1224|Proteobacteria,1RPJ9@1236|Gammaproteobacteria,1XJZY@135619|Oceanospirillales 135619|Oceanospirillales KT Phage shock protein A (IM30), suppresses sigma54-dependent transcription - - - - - - - - - - - - PspA_IM30 k59_4613_1 765911.Thivi_2347 1.59e-38 137.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales 135613|Chromatiales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_12023_1 335543.Sfum_1817 2.21e-99 307.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MRH3@213462|Syntrophobacterales 28221|Deltaproteobacteria S ABC1 family - - - ko:K03688 - - - - ko00000 - - - ABC1,RIO1 k59_4616_1 436114.SYO3AOP1_1556 0.000375 48.9 COG3547@1|root,COG3547@2|Bacteria,2G5FE@200783|Aquificae 200783|Aquificae L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_76217_1 177437.HRM2_35530 3.04e-59 199.0 COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria,2MHV1@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 k59_180358_1 63737.Npun_R3027 4.26e-36 140.0 COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIST@1161|Nostocales 1117|Cyanobacteria Q acyl transferase domain - - - ko:K16129 ko01054,map01054 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt k59_154206_1 1120705.FG95_02911 3.13e-36 138.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - - - - - - - - - - rve k59_70661_3 335543.Sfum_3741 5.8e-28 128.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1,sCache_2 k59_12029_1 439235.Dalk_2944 5.32e-05 44.7 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_12029_2 330214.NIDE1705 7.23e-149 428.0 COG0468@1|root,COG0468@2|Bacteria,3J0C1@40117|Nitrospirae 40117|Nitrospirae L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_63922_1 1121121.KB894285_gene13 2.16e-77 275.0 COG0331@1|root,COG2070@1|root,COG3321@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,1UG0E@1239|Firmicutes,4HE1K@91061|Bacilli,26RF2@186822|Paenibacillaceae 91061|Bacilli I Malonyl CoA-acyl carrier protein transacylase pfaD - - ko:K15329 - - - - ko00000,ko01008 - - - Acyl_transf_1,NMO k59_63922_2 545693.BMQ_1682 7.21e-36 150.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli,1ZEIH@1386|Bacillus 91061|Bacilli IQ acyl-CoA ligase ydaB - - - - - - - - - - - AMP-binding,AMP-binding_C k59_63922_3 113355.CM001775_gene1588 3.48e-25 114.0 COG0318@1|root,COG2267@1|root,COG3321@1|root,COG0318@2|Bacteria,COG2267@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria 1117|Cyanobacteria Q Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - AMP-binding,Abhydrolase_1,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Sulfotransfer_3,ketoacyl-synt k59_63922_4 261292.Nit79A3_1919 5.58e-25 98.2 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2VTIQ@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_123051_1 525904.Tter_0805 3.23e-103 313.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_187555_1 1121405.dsmv_0557 3.15e-77 248.0 COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MJ4K@213118|Desulfobacterales 28221|Deltaproteobacteria CK PFAM Acetyl-CoA hydrolase transferase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1 k59_64093_1 439235.Dalk_3994 2.31e-110 338.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_89607_1 497964.CfE428DRAFT_0230 0.000353 48.9 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,46TGZ@74201|Verrucomicrobia 74201|Verrucomicrobia T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_206140_2 880072.Desac_1428 4.36e-57 187.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MR47@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_123054_1 1411685.U062_00524 6.81e-57 193.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1J5QT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_167366_2 1123393.KB891327_gene355 9.45e-15 70.9 COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,2WGE2@28216|Betaproteobacteria,1KSQD@119069|Hydrogenophilales 119069|Hydrogenophilales G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_25210_1 290317.Cpha266_0617 4.2e-51 193.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1FDBJ@1090|Chlorobi 1090|Chlorobi T histidine kinase A domain protein - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,Response_reg,dCache_3 k59_89609_1 1121403.AUCV01000002_gene658 2.17e-54 192.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MI3D@213118|Desulfobacterales 28221|Deltaproteobacteria L UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_148157_1 335543.Sfum_2118 5.25e-85 269.0 COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MR1P@213462|Syntrophobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_193243_1 768671.ThimaDRAFT_0872 5.87e-29 118.0 COG1289@1|root,COG1289@2|Bacteria,1QJEM@1224|Proteobacteria,1SMXK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Aromatic acid exporter family member 1 VPA1578 - - - - - - - - - - - FUSC k59_50921_2 395493.BegalDRAFT_2204 6.2e-63 203.0 COG1891@1|root,COG1891@2|Bacteria,1RGX0@1224|Proteobacteria,1S6UW@1236|Gammaproteobacteria,462KH@72273|Thiotrichales 72273|Thiotrichales S 4-HFC-P synthase - - - - - - - - - - - - 4HFCP_synth k59_50921_3 1236959.BAMT01000013_gene2998 2.7e-68 213.0 COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,2VS9E@28216|Betaproteobacteria,2KMR7@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function (DUF447) - - - ko:K09154 - - - - ko00000 - - - DUF447 k59_50921_4 765913.ThidrDRAFT_1340 3.8e-155 449.0 COG0294@1|root,COG0294@2|Bacteria,1MWM3@1224|Proteobacteria,1RZMG@1236|Gammaproteobacteria 1236|Gammaproteobacteria H dihydropteroate - - - - - - - - - - - - - k59_129469_1 396595.TK90_0967 1.42e-70 226.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RYYZ@1236|Gammaproteobacteria,1WZQD@135613|Chromatiales 135613|Chromatiales P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_129469_2 717772.THIAE_07010 8.76e-120 351.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,1RVP9@1236|Gammaproteobacteria,461M0@72273|Thiotrichales 72273|Thiotrichales P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_129469_3 1269813.ATUL01000011_gene591 1.06e-176 514.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_89619_1 929556.Solca_1852 9.33e-07 57.4 COG0526@1|root,COG0526@2|Bacteria,4NRZT@976|Bacteroidetes,1IYXQ@117747|Sphingobacteriia 976|Bacteroidetes CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Redoxin k59_64106_1 1267535.KB906767_gene5363 2.28e-44 160.0 COG3547@1|root,COG3547@2|Bacteria,3Y6PK@57723|Acidobacteria 57723|Acidobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_187562_1 1121405.dsmv_3215 2.36e-13 72.0 COG1032@1|root,COG1032@2|Bacteria,1R52J@1224|Proteobacteria,42P9G@68525|delta/epsilon subdivisions,2WKFU@28221|Deltaproteobacteria,2MIVS@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_161212_1 765913.ThidrDRAFT_3266 2.72e-78 253.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RY40@1236|Gammaproteobacteria,1WXJ9@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_129470_1 1265505.ATUG01000001_gene3405 2.29e-40 152.0 COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N,YbbR k59_12205_1 292415.Tbd_0654 3.72e-105 312.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM Transketolase central region - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_65931_2 1049564.TevJSym_ab00020 4.76e-212 598.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4V4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_65931_3 1049564.TevJSym_ab00030 8.37e-26 107.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_7706_1 1173020.Cha6605_6264 9.43e-42 143.0 COG5654@1|root,COG5654@2|Bacteria,1G7GA@1117|Cyanobacteria 1117|Cyanobacteria S PFAM RES domain - - - - - - - - - - - - RES k59_7706_2 1123368.AUIS01000015_gene2663 6.02e-36 128.0 COG5642@1|root,COG5642@2|Bacteria,1RJWF@1224|Proteobacteria,1S8GN@1236|Gammaproteobacteria,2NE1Q@225057|Acidithiobacillales 1236|Gammaproteobacteria S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_189235_1 1380346.JNIH01000047_gene6761 1.16e-22 104.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2I9RW@201174|Actinobacteria 201174|Actinobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_156731_1 1049564.TevJSym_am00790 1.1e-133 392.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1J4FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0066 HMGL-like,LeuA_dimer k59_137207_1 46234.ANA_C13142 4.67e-154 451.0 COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales 1117|Cyanobacteria L PFAM Transposase DDE domain - - - ko:K07495 - - - - ko00000 - - - DDE_5,DDE_Tnp_1 k59_130968_2 1122134.KB893650_gene623 2.24e-41 140.0 COG1361@1|root,COG1361@2|Bacteria,1NNGX@1224|Proteobacteria 1224|Proteobacteria M Toxin with a conserved tryptophan and TIP tripeptide motif - - - - - - - - - - - - DUF4157,Tox-WTIP k59_169846_1 349521.HCH_02592 1.17e-21 96.7 COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,1XN5T@135619|Oceanospirillales 135619|Oceanospirillales E Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_169846_2 1049564.TevJSym_aj00030 3.74e-30 118.0 2BWPY@1|root,2Z8BI@2|Bacteria,1QHHB@1224|Proteobacteria,1RP8D@1236|Gammaproteobacteria,1J916@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_104821_1 207954.MED92_04402 2.23e-133 388.0 COG0348@1|root,COG0348@2|Bacteria,1QTQB@1224|Proteobacteria,1RXUW@1236|Gammaproteobacteria,1XN2H@135619|Oceanospirillales 135619|Oceanospirillales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_10,Fer4_5 k59_27161_1 1049564.TevJSym_ak00940 1.51e-192 546.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1J4D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_59565_1 994479.GL877882_gene6945 4.44e-13 73.9 COG3666@1|root,COG3666@2|Bacteria,2IA0I@201174|Actinobacteria 201174|Actinobacteria L Protein involved in DNA binding, transposase activity and DNA transposition - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_46495_1 1121456.ATVA01000012_gene2676 4.7e-31 122.0 COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2M7W6@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,TSP_3,VWA,VWA_2 k59_91941_1 1218084.BBJK01000021_gene2256 7.5e-97 291.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,1K1FH@119060|Burkholderiaceae 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5,6.2.1.9 ko:K01902,ko:K08692 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_91941_2 391165.GbCGDNIH1_0052 7.79e-137 401.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JW84@204441|Rhodospirillales 204441|Rhodospirillales C ATP-grasp domain - - 6.2.1.9 ko:K14067 ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200 M00346 R01256 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_202244_2 153948.NAL212_0322 1.22e-71 224.0 28PEU@1|root,2ZC6A@2|Bacteria,1RAPI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_72433_1 686340.Metal_0787 2.86e-104 304.0 COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,1S55P@1236|Gammaproteobacteria,1XG9Z@135618|Methylococcales 135618|Methylococcales S PFAM Flavin - - - - - - - - - - - - Flavin_Reduct k59_124420_1 1265505.ATUG01000001_gene3058 2.32e-70 230.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2WN6Z@28221|Deltaproteobacteria,2MMGX@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 k59_156739_1 91464.S7335_701 1.21e-21 91.3 COG0758@1|root,COG0758@2|Bacteria,1GACU@1117|Cyanobacteria 1117|Cyanobacteria LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_182822_1 450380.JPSY01000001_gene1186 9.79e-42 160.0 29GCA@1|root,303A5@2|Bacteria,2H1W0@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_104824_1 1565129.JSFF01000008_gene2585 1.42e-25 105.0 COG1309@1|root,COG1309@2|Bacteria,1N0XU@1224|Proteobacteria,1S91U@1236|Gammaproteobacteria,2QB0T@267890|Shewanellaceae 1236|Gammaproteobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG k59_104824_2 354242.CJJ81176_0955 1.41e-07 52.4 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,43BJD@68525|delta/epsilon subdivisions,2YNEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I 2-acylglycerophosphoethanolamine acyltransferase aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_98263_2 1049564.TevJSym_ad00490 3.57e-220 622.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_98263_3 1049564.TevJSym_ad00500 1.48e-63 212.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter phaD - 1.6.5.3 ko:K00342,ko:K05561,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_65945_1 555779.Dthio_PD0546 1.02e-49 167.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2M938@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_7712_1 1049564.TevJSym_an00780 1.66e-254 710.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1J4QJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EQ Hydantoinase B/oxoprolinase hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_7712_2 1049564.TevJSym_an00790 2.34e-84 251.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1J4K8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N k59_130981_1 56780.SYN_00833 5.1e-56 190.0 COG1305@1|root,COG1305@2|Bacteria,1Q1D3@1224|Proteobacteria,43772@68525|delta/epsilon subdivisions,2WSIA@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_130981_2 767817.Desgi_3230 6.64e-08 54.7 COG0655@1|root,COG0655@2|Bacteria,1V5BY@1239|Firmicutes,24JZN@186801|Clostridia,2624Q@186807|Peptococcaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_195428_1 1049564.TevJSym_br00090 1.02e-103 322.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1J5GE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_33604_1 439235.Dalk_1502 5.05e-25 105.0 COG3842@1|root,COG3842@2|Bacteria,1QWPH@1224|Proteobacteria,43E0E@68525|delta/epsilon subdivisions,2X75F@28221|Deltaproteobacteria,2MPKB@213118|Desulfobacterales 28221|Deltaproteobacteria P ABC transporter - - 3.6.3.55 ko:K06857 ko02010,map02010 M00186 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.2,3.A.1.6.4 - - ABC_tran k59_117998_1 1174684.EBMC1_12205 1.87e-09 60.1 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K2SD@204457|Sphingomonadales 204457|Sphingomonadales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_117998_2 713586.KB900536_gene1975 4.59e-82 246.0 COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1RRB4@1236|Gammaproteobacteria,1WXB8@135613|Chromatiales 135613|Chromatiales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_202254_1 1125863.JAFN01000001_gene558 1.16e-20 95.1 COG0644@1|root,COG0644@2|Bacteria,1PFC1@1224|Proteobacteria,42VN7@68525|delta/epsilon subdivisions,2WR8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria C FAD binding domain - - 1.3.99.38 ko:K21401 - - - - ko00000,ko01000 - - - FAD_binding_3 k59_59577_1 270374.MELB17_04957 4.53e-37 127.0 COG3549@1|root,COG3549@2|Bacteria,1MZ4I@1224|Proteobacteria,1S9CP@1236|Gammaproteobacteria,467P3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Plasmid maintenance system killer protein - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_59577_2 754477.Q7C_1432 1.39e-39 134.0 COG3093@1|root,COG3093@2|Bacteria,1N2BD@1224|Proteobacteria,1S8Z4@1236|Gammaproteobacteria 1236|Gammaproteobacteria K plasmid maintenance system antidote protein higA - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_14065_1 868595.Desca_2643 1.75e-24 100.0 COG0394@1|root,COG0698@1|root,COG0394@2|Bacteria,COG0698@2|Bacteria,1V6SG@1239|Firmicutes,24MMZ@186801|Clostridia,26776@186807|Peptococcaceae 186801|Clostridia G Low molecular weight phosphatase family - - 3.1.3.48,5.3.1.6 ko:K01104,ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LMWPc,LacAB_rpiB k59_59689_1 1123053.AUDG01000001_gene2382 6.51e-56 182.0 COG3409@1|root,COG3409@2|Bacteria,1N4WW@1224|Proteobacteria,1S9UQ@1236|Gammaproteobacteria,1WZ5G@135613|Chromatiales 135613|Chromatiales M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - CsgG k59_59689_2 1006006.Mcup_0487 7.32e-05 43.1 COG1324@1|root,arCOG04231@2157|Archaea,2XR6Y@28889|Crenarchaeota 28889|Crenarchaeota P PFAM CutA1 divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 k59_98398_1 879212.DespoDRAFT_00919 8.8e-100 308.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,2MHMS@213118|Desulfobacterales 28221|Deltaproteobacteria S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_85563_1 1410620.SHLA_15c000840 8.4e-81 254.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM Phage - - - - - - - - - - - - Terminase_6C k59_72571_1 265072.Mfla_0400 2e-114 337.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,2KMA6@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_72571_4 397291.C804_04464 5.21e-115 353.0 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,27JDB@186928|unclassified Lachnospiraceae 186801|Clostridia M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_72571_5 697282.Mettu_2862 1.78e-34 130.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1XGA0@135618|Methylococcales 135618|Methylococcales G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - - - - - - - - - - - NTP_transferase k59_59690_1 156889.Mmc1_1409 9.32e-56 191.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_195506_1 1198232.CYCME_1950 8.77e-12 65.5 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,45ZS4@72273|Thiotrichales 72273|Thiotrichales S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_195506_5 314231.FP2506_17829 5.95e-85 272.0 COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2TSXN@28211|Alphaproteobacteria,2PJ3D@255475|Aurantimonadaceae 28211|Alphaproteobacteria S Pfam:DUF989 MA20_17625 - - - - - - - - - - - Urate_ox_N k59_195506_6 1340493.JNIF01000003_gene1403 5.14e-100 297.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_195506_8 59538.XP_005965873.1 4.29e-294 847.0 COG4631@1|root,KOG0430@2759|Eukaryota,38GEI@33154|Opisthokonta,3BC8Q@33208|Metazoa,3CXMB@33213|Bilateria,4842N@7711|Chordata,48ZCW@7742|Vertebrata,3J9KI@40674|Mammalia,4J6CM@91561|Cetartiodactyla 33208|Metazoa F Xanthine dehydrogenase - - 1.17.1.4,1.17.3.2,1.2.3.1 ko:K00106,ko:K00157 ko00230,ko00232,ko00280,ko00350,ko00380,ko00750,ko00760,ko00830,ko00982,ko00983,ko01100,ko01110,ko01120,ko04146,ko04630,map00230,map00232,map00280,map00350,map00380,map00750,map00760,map00830,map00982,map00983,map01100,map01110,map01120,map04146,map04630 M00546 R01709,R01768,R01769,R02103,R02107,R02125,R02657,R03871,R04085,R04904,R07942,R07977,R07978,R07979,R08235,R08349,R08384,R08408 RC00075,RC00080,RC00143,RC00218,RC00242,RC01073,RC01074,RC02017,RC02199 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2 k59_170031_1 1049564.TevJSym_ac01460 3.88e-50 178.0 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1J5XY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Oxygen tolerance batD - - - - - - - - - - - BatD k59_27304_1 1122185.N792_07230 1.11e-29 115.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,1X52V@135614|Xanthomonadales 135614|Xanthomonadales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_27304_2 1256908.HMPREF0373_02219 2.3e-20 86.7 COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia,25XBE@186806|Eubacteriaceae 186801|Clostridia L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_27304_3 1049564.TevJSym_ah00940 6.7e-40 136.0 COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Sulfur oxidation soxX - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 k59_156885_1 717231.Flexsi_1773 0.000388 49.3 COG0747@1|root,COG0747@2|Bacteria,2GEIN@200930|Deferribacteres 200930|Deferribacteres E Peptide nickel ABC transporter, substrate-binding protein - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_111574_2 879212.DespoDRAFT_02386 1.47e-18 85.1 COG2357@1|root,COG2357@2|Bacteria,1RCHE@1224|Proteobacteria,42PPK@68525|delta/epsilon subdivisions,2WJBS@28221|Deltaproteobacteria,2MHSG@213118|Desulfobacterales 28221|Deltaproteobacteria S Region found in RelA / SpoT proteins - - - - - - - - - - - - RelA_SpoT k59_144079_1 331869.BAL199_28740 4.94e-31 122.0 COG3677@1|root,COG3677@2|Bacteria,1REPF@1224|Proteobacteria,2U8CB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_33780_1 1049564.TevJSym_ca00050 7.79e-71 239.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_137309_2 335543.Sfum_0379 9.95e-78 244.0 COG1541@1|root,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,2MRDJ@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_124587_1 335283.Neut_2269 1.67e-68 230.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,373XP@32003|Nitrosomonadales 28216|Betaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_14069_1 751945.Theos_0507 8.25e-11 69.3 COG1173@1|root,COG1173@2|Bacteria,1WIH4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus EP ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_1143_1 933262.AXAM01000046_gene145 6.39e-08 53.9 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2MIFW@213118|Desulfobacterales 28221|Deltaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_66052_1 767817.Desgi_2859 1.41e-94 337.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,26097@186807|Peptococcaceae 186801|Clostridia T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - 7TMR-DISM_7TM,AAA_16,GAF,GAF_2,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_66052_2 156889.Mmc1_3408 7.5e-131 384.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2U2AJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_40322_1 1056820.KB900638_gene66 4.33e-20 90.9 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_163401_1 365046.Rta_12680 0.000728 46.6 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs-related protein - - - - - - - - - - - - RHS,RHS_repeat k59_104958_1 1125863.JAFN01000001_gene3086 1.79e-44 155.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_144080_1 177437.HRM2_34570 4.31e-106 322.0 COG0477@1|root,COG2814@2|Bacteria,1R9V9@1224|Proteobacteria,42Q1C@68525|delta/epsilon subdivisions,2WK7P@28221|Deltaproteobacteria,2MMQA@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_60807_2 926569.ANT_22180 3.26e-21 96.3 COG1928@1|root,COG1928@2|Bacteria,2G9TC@200795|Chloroflexi 200795|Chloroflexi O C-terminal four TMM region of protein-O-mannosyltransferase - - - - - - - - - - - - - k59_60807_3 105559.Nwat_0326 8.36e-145 426.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1X2ND@135613|Chromatiales 135613|Chromatiales KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_8,Sigma54_activat k59_28366_1 700598.Niako_5041 4.6e-47 171.0 COG0567@1|root,COG0567@2|Bacteria,4NEU9@976|Bacteroidetes,1IQYB@117747|Sphingobacteriia 976|Bacteroidetes C 2-oxoglutarate dehydrogenase, E1 sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_60808_1 290317.Cpha266_1671 2.59e-16 82.8 COG2885@1|root,COG2885@2|Bacteria,1FE7F@1090|Chlorobi 1090|Chlorobi M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_2080_1 2340.JV46_06490 1.3e-30 118.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_2080_2 1150621.SMUL_2595 4.25e-170 496.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,42P71@68525|delta/epsilon subdivisions,2YNAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_184306_1 485915.Dret_0751 8.04e-82 255.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2M838@213115|Desulfovibrionales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_41670_2 870187.Thini_3341 0.0 902.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales 72273|Thiotrichales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_41670_3 85643.Tmz1t_3009 4.13e-13 68.6 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KVFI@206389|Rhodocyclales 206389|Rhodocyclales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_177605_1 868864.Dester_0351 5.94e-06 52.0 COG3005@1|root,COG3005@2|Bacteria,2G4K3@200783|Aquificae 200783|Aquificae P denitrification pathway - - - - - - - - - - - - - k59_73461_1 1049564.TevJSym_ax00160 1.34e-235 653.0 COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1J9DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase sqr - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_2082_1 247633.GP2143_15031 1.36e-96 294.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1J54Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_60813_1 941449.dsx2_1873 4.15e-39 149.0 COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2M8ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,PA,Peptidase_M28 k59_125864_1 1380391.JIAS01000020_gene1640 3.26e-17 77.8 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,2JS8N@204441|Rhodospirillales 204441|Rhodospirillales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_125864_2 1049564.TevJSym_ag01060 5.87e-99 297.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1J4FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing LysM domain lysM - - - - - - - - - - - LysM k59_67163_1 90813.JQMT01000001_gene1820 6.64e-83 263.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,463SJ@72273|Thiotrichales 72273|Thiotrichales P STAS domain - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_203374_1 1249627.D779_0831 3.49e-73 241.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_203374_2 1049564.TevJSym_ac01050 8.2e-57 192.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1J4P5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcSMS35_1347.EcSMS35_4486 PGI k59_119444_1 1442599.JAAN01000045_gene2777 3.38e-09 62.4 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1X4CP@135614|Xanthomonadales 135614|Xanthomonadales M RHS Repeat - - - - - - - - - - - - RHS_repeat k59_151652_1 157783.LK03_14765 2.78e-34 130.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1S1RT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_132348_1 400668.Mmwyl1_2898 1.22e-87 258.0 COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,1SCHM@1236|Gammaproteobacteria,1XQK0@135619|Oceanospirillales 135619|Oceanospirillales S 3-demethylubiquinone-9 3-methyltransferase - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt k59_132348_2 1123518.ARWI01000001_gene232 1.4e-145 410.0 COG0110@1|root,COG0110@2|Bacteria,1MUCJ@1224|Proteobacteria,1RPPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0110 Acetyltransferase (isoleucine patch superfamily) sat - - ko:K18234 - - - - ko00000,ko01000,ko01504 - - - Hexapep k59_2088_1 880071.Fleli_2863 1.33e-84 266.0 COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,47JJR@768503|Cytophagia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_28371_2 765911.Thivi_3833 4.66e-152 441.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1WWCM@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_28371_3 765911.Thivi_3834 3.24e-33 117.0 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,1S61Y@1236|Gammaproteobacteria,1WZ34@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0250 family - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_28371_4 1282356.H045_17480 6.61e-67 209.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1YNXZ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718 BPL_LplA_LipB k59_47761_1 1120934.KB894411_gene6809 1.01e-24 109.0 COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4E0V6@85010|Pseudonocardiales 201174|Actinobacteria EK Alanine-glyoxylate amino-transferase - - - ko:K03710,ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000,ko03000 - - - Aminotran_1_2,GntR k59_34971_1 1049564.TevJSym_bb00230 5.21e-101 326.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_93516_1 1265502.KB906000_gene3325 1.28e-11 60.8 2DPUF@1|root,333EK@2|Bacteria,1NC52@1224|Proteobacteria,2VX5H@28216|Betaproteobacteria,4AFM5@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_41686_1 1165841.SULAR_09619 1.62e-146 415.0 COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,42TT9@68525|delta/epsilon subdivisions 1224|Proteobacteria O methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_8995_1 1121405.dsmv_1169 1.44e-99 301.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MI7I@213118|Desulfobacterales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_67171_1 1265505.ATUG01000002_gene1861 1.9e-57 184.0 COG4936@1|root,COG4936@2|Bacteria,1RIWX@1224|Proteobacteria,42TB2@68525|delta/epsilon subdivisions,2WPI6@28221|Deltaproteobacteria,2MKFB@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sensory domain found in PocR - - - - - - - - - - - - PocR k59_34974_1 1121918.ARWE01000001_gene3018 1.43e-38 139.0 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,42RKD@68525|delta/epsilon subdivisions,2WNAE@28221|Deltaproteobacteria,43USK@69541|Desulfuromonadales 28221|Deltaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_151659_1 1120934.KB894420_gene2288 4.79e-22 102.0 COG4932@1|root,COG4932@2|Bacteria,2I434@201174|Actinobacteria 201174|Actinobacteria M domain protein - - - - - - - - - - - - CarboxypepD_reg,DUF11,SdrD_B k59_86701_2 1336208.JADY01000010_gene3315 1.48e-156 468.0 COG0412@1|root,COG0412@2|Bacteria,1QV1D@1224|Proteobacteria,2TWBD@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Tannase and feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_28375_1 933262.AXAM01000006_gene1840 9.39e-81 249.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MIIH@213118|Desulfobacterales 28221|Deltaproteobacteria O heat shock protein DnaJ domain protein - - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_190501_1 880072.Desac_0318 6.59e-05 45.1 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MQAI@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_190501_2 1089553.Tph_c13350 3.29e-19 85.5 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,42EPG@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_184335_1 1123401.JHYQ01000001_gene1818 5.72e-37 141.0 COG4987@1|root,COG4987@2|Bacteria,1QU1P@1224|Proteobacteria,1RQD7@1236|Gammaproteobacteria,46051@72273|Thiotrichales 72273|Thiotrichales V ATP-binding protein cydC - - ko:K16012 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran k59_99363_1 330214.NIDE0114 7.34e-86 277.0 COG5283@1|root,COG5283@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PhageMin_Tail,SLT k59_28381_1 580332.Slit_2852 6.93e-41 139.0 COG2149@1|root,COG2149@2|Bacteria,1N173@1224|Proteobacteria,2VWEE@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF202) - - - ko:K00389 - - - - ko00000 - - - DUF202 k59_132365_1 1049564.TevJSym_al00460 2.1e-58 193.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1J5MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 LpxK k59_138283_1 314285.KT71_13854 1.78e-159 477.0 COG0433@1|root,COG0433@2|Bacteria,1QUPX@1224|Proteobacteria,1T20D@1236|Gammaproteobacteria,1JC04@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S TraM recognition site of TraD and TraG - - - - - - - - - - - - T4SS-DNA_transf,TraG-D_C,TrwB_AAD_bind k59_138283_2 205914.HS_1750 2.61e-07 55.8 COG3279@1|root,COG3279@2|Bacteria,1RISK@1224|Proteobacteria,1S5VM@1236|Gammaproteobacteria,1Y8T4@135625|Pasteurellales 135625|Pasteurellales KT Protein of unknown function (DUF2859) - - - - - - - - - - - - DUF2859 k59_138283_3 1051646.VITU9109_10352 1.26e-33 122.0 COG0741@1|root,COG0741@2|Bacteria,1RDXX@1224|Proteobacteria,1S3N9@1236|Gammaproteobacteria,1XYAB@135623|Vibrionales 135623|Vibrionales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - - k59_86709_1 1217714.F975_01637 1.77e-23 104.0 COG0454@1|root,COG1040@1|root,COG0456@2|Bacteria,COG1040@2|Bacteria,1QV41@1224|Proteobacteria,1RSAP@1236|Gammaproteobacteria,3NM26@468|Moraxellaceae 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_177624_1 395494.Galf_2621 3.63e-25 101.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria 28216|Betaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_177624_2 933262.AXAM01000075_gene2959 6.27e-60 218.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2WKBQ@28221|Deltaproteobacteria,2MK7Q@213118|Desulfobacterales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_157981_2 1049564.TevJSym_av00090 8.69e-124 362.0 COG1360@1|root,COG1360@2|Bacteria,1QUFR@1224|Proteobacteria,1T1XE@1236|Gammaproteobacteria,1J4JC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_157981_5 1049564.TevJSym_ar00030 3.29e-96 286.0 COG1977@1|root,COG3536@1|root,COG1977@2|Bacteria,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1J6I8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein conserved in bacteria - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - DUF971 k59_157981_6 1049564.TevJSym_ar00040 7.68e-85 265.0 COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,1J6Y1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretion system protein C gspC GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02452 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - PDZ_2,T2SSC k59_164393_1 439235.Dalk_2211 1.92e-61 206.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_93520_2 998088.B565_2985 8.92e-63 221.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1Y3ZY@135624|Aeromonadales 135624|Aeromonadales S Cell wall degradation protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_22125_2 765912.Thimo_1763 7e-56 180.0 COG4275@1|root,COG4275@2|Bacteria,1NE2N@1224|Proteobacteria 1224|Proteobacteria P Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist k59_22125_3 765912.Thimo_1762 1.83e-95 286.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1WWRC@135613|Chromatiales 135613|Chromatiales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.25 ko:K02045 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.1,3.A.1.6.3 - - ABC_tran k59_22125_4 765912.Thimo_1761 3.28e-211 603.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1WWS0@135613|Chromatiales 135613|Chromatiales P inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_22125_5 765912.Thimo_1760 1.59e-176 499.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1WWM0@135613|Chromatiales 135613|Chromatiales P extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_22125_7 1123228.AUIH01000038_gene2741 2.04e-99 305.0 2AQZG@1|root,31G87@2|Bacteria,1RJKR@1224|Proteobacteria,1S81D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S FlgD Ig-like domain - - - - - - - - - - - - FlgD_ig k59_22125_8 626887.J057_21695 1.77e-179 541.0 COG3291@1|root,COG3291@2|Bacteria,1MWIT@1224|Proteobacteria,1S1VQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PKD domain - - - - - - - - - - - - FlgD_ig,PKD k59_14974_1 1049564.TevJSym_ai00870 1.69e-107 332.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1J4VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_112678_1 1049564.TevJSym_ag00060 1.81e-118 341.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1J56A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0625 Glutathione S-transferase sspA GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N,GST_N_3 k59_157986_1 1121422.AUMW01000007_gene3129 3.25e-53 189.0 COG1449@1|root,COG1449@2|Bacteria,1UVAN@1239|Firmicutes,24B0Y@186801|Clostridia,260ZW@186807|Peptococcaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - DUF3536,Glyco_hydro_57 k59_171254_1 269799.Gmet_0045 1.51e-14 73.9 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2WNT0@28221|Deltaproteobacteria,43VVX@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_73489_1 1121403.AUCV01000016_gene4431 8.89e-38 138.0 COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,42RY0@68525|delta/epsilon subdivisions,2WNYN@28221|Deltaproteobacteria,2MPFN@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterised ACR, YagE family COG1723 - - - - - - - - - - - - DUF155 k59_190510_1 179408.Osc7112_1555 3.33e-06 54.3 COG0642@1|root,COG0745@1|root,COG2114@1|root,COG2770@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - ko:K19694 - - - - ko00000,ko01001,ko02022 - - - Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1 k59_184509_3 59196.RICGR_1467 5.09e-12 61.6 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1JF6B@118969|Legionellales 118969|Legionellales S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_54315_1 1121405.dsmv_3409 3.56e-99 298.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2MHYY@213118|Desulfobacterales 28221|Deltaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409 Glycos_transf_4,MraY_sig1 k59_86904_1 555779.Dthio_PD0916 2.71e-45 167.0 COG1148@1|root,COG4231@1|root,COG1148@2|Bacteria,COG4231@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2M7SC@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,Pyr_redox_2 k59_106249_1 420662.Mpe_A2043 1.64e-42 143.0 COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,2VU9B@28216|Betaproteobacteria,1KM5A@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_106249_2 1123354.AUDR01000015_gene401 1.44e-39 137.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2VRGX@28216|Betaproteobacteria,1KTD8@119069|Hydrogenophilales 119069|Hydrogenophilales O Hsp20/alpha crystallin family - - - - - - - - - - - - HSP20 k59_106249_3 1492922.GY26_01705 1.52e-29 108.0 COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,1SE7J@1236|Gammaproteobacteria,1J77U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K MerR HTH family regulatory protein cbpM - - ko:K18997 - - - - ko00000,ko03036 - - - MerR_2 k59_106249_4 1049564.TevJSym_af00130 2.17e-155 444.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1J5VE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DnaJ-class molecular chaperone cbpA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_190738_1 688245.CtCNB1_0941 2.52e-15 74.3 COG0778@1|root,COG0778@2|Bacteria,1RBZQ@1224|Proteobacteria,2VQTZ@28216|Betaproteobacteria,4ADUH@80864|Comamonadaceae 28216|Betaproteobacteria C nitroreductase - - - ko:K09019 ko00240,ko01100,map00240,map01100 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Nitroreductase k59_190738_2 105559.Nwat_2821 2.58e-211 620.0 COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1WXID@135613|Chromatiales 135613|Chromatiales S doubled CXXCH - - - - - - - - - - - - Cytochrome_C554,Paired_CXXCH_1,TPR_19,TPR_8 k59_151877_1 706587.Desti_0186 2.33e-105 314.0 COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1RABP@1224|Proteobacteria,42QQA@68525|delta/epsilon subdivisions,2WMRX@28221|Deltaproteobacteria,2MQEY@213462|Syntrophobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362,Fer4 k59_54316_1 857087.Metme_3144 3.06e-30 121.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1XDM2@135618|Methylococcales 135618|Methylococcales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_138500_1 1121405.dsmv_2224 1.18e-58 206.0 COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,PA,Peptidase_M28 k59_28562_1 933262.AXAM01000015_gene101 3.22e-64 212.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_190740_1 1049564.TevJSym_ap00550 5.7e-150 428.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_67483_1 1236542.BALM01000013_gene3707 2.91e-29 117.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,2Q9A7@267890|Shewanellaceae 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_63013_6 1279019.ARQK01000048_gene117 2.95e-51 175.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1WW2T@135613|Chromatiales 135613|Chromatiales G TIGRFAM HAD-superfamily subfamily IIA hydrolase like protein - - - - - - - - - - - - Hydrolase_6,Hydrolase_like k59_172620_1 156889.Mmc1_1517 4.31e-136 401.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2TT73@28211|Alphaproteobacteria 2|Bacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_172620_2 765912.Thimo_2911 8.35e-283 781.0 COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1WVY7@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_172620_4 1121451.DESAM_21665 1.95e-78 244.0 COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria,43BJZ@68525|delta/epsilon subdivisions,2X6XU@28221|Deltaproteobacteria,2MBAK@213115|Desulfovibrionales 28221|Deltaproteobacteria S Serine aminopeptidase, S33 - - 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_11033_1 7029.ACYPI004424-PA 3.9e-17 80.9 KOG2649@1|root,KOG2649@2759|Eukaryota,38DE0@33154|Opisthokonta,3B9RU@33208|Metazoa,3CZBB@33213|Bilateria,41VV6@6656|Arthropoda,3SGSS@50557|Insecta,3ECJP@33342|Paraneoptera 33208|Metazoa S Zn_pept - GO:0001932,GO:0001933,GO:0002009,GO:0002165,GO:0003008,GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006518,GO:0006807,GO:0006937,GO:0007275,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0007610,GO:0007611,GO:0007613,GO:0007616,GO:0008064,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009892,GO:0009987,GO:0010467,GO:0010563,GO:0010605,GO:0010638,GO:0016043,GO:0016485,GO:0016787,GO:0017171,GO:0019220,GO:0019222,GO:0019538,GO:0030832,GO:0030833,GO:0030838,GO:0031323,GO:0031324,GO:0031334,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032271,GO:0032273,GO:0032501,GO:0032502,GO:0032535,GO:0032956,GO:0032970,GO:0033043,GO:0034641,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0042325,GO:0042326,GO:0043170,GO:0043254,GO:0043603,GO:0044057,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045936,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048563,GO:0048569,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0050789,GO:0050794,GO:0050877,GO:0050890,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051174,GO:0051239,GO:0051246,GO:0051248,GO:0051493,GO:0051495,GO:0051604,GO:0060255,GO:0060429,GO:0060562,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071704,GO:0071840,GO:0080090,GO:0090066,GO:0090257,GO:0110053,GO:0140096,GO:1901564,GO:1902903,GO:1902905 3.4.17.22 ko:K07752 - - - - ko00000,ko01000,ko01002 - - - CarboxypepD_reg,Peptidase_M14 k59_11033_2 397945.Aave_0610 1.41e-215 614.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,4AA35@80864|Comamonadaceae 28216|Betaproteobacteria C FAD dependent oxidoreductase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_69764_1 395495.Lcho_0175 2.12e-113 332.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1KJNR@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_172705_2 1049564.TevJSym_av00160 1.7e-175 503.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0008 Glutamyl- and glutaminyl-tRNA synthetases glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_11222_1 1249627.D779_0846 7.57e-17 80.1 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_44528_1 998674.ATTE01000001_gene2613 2.09e-24 97.1 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,462CF@72273|Thiotrichales 72273|Thiotrichales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_44528_2 697282.Mettu_0752 3.42e-47 166.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1XES4@135618|Methylococcales 135618|Methylococcales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_153517_1 933262.AXAM01000010_gene1350 1.57e-22 101.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_166350_1 1232437.KL662020_gene705 2.31e-85 267.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_205299_1 1168065.DOK_02296 2.52e-252 706.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_108430_1 686340.Metal_3936 4.93e-38 130.0 COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,1XFM1@135618|Methylococcales 135618|Methylococcales S Cupin domain - - - ko:K11312 - - - - ko00000 - - - Cupin_2 k59_3954_3 1502851.FG93_03415 3.4e-53 176.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,3JRP5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family MA20_37085 - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Ubie_methyltran k59_114653_1 983917.RGE_17400 5.95e-42 152.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,1KJC2@119065|unclassified Burkholderiales 28216|Betaproteobacteria T signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 k59_11232_1 404380.Gbem_0895 6.34e-45 161.0 COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - - - - - - - - - - - DisA_N,YbbR k59_101387_1 880072.Desac_1150 2.09e-33 122.0 2EFDI@1|root,3396C@2|Bacteria,1N9D7@1224|Proteobacteria,42W2W@68525|delta/epsilon subdivisions,2WR8J@28221|Deltaproteobacteria,2MS20@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_192468_2 1219581.HMPREF1628_03360 4.38e-23 99.4 COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4D30R@85005|Actinomycetales 201174|Actinobacteria G Pyruvate kinase pyk GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_186608_1 1121396.KB893084_gene405 3.84e-90 274.0 COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,42RI3@68525|delta/epsilon subdivisions,2WNVC@28221|Deltaproteobacteria,2MJX3@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_153520_1 1116472.MGMO_112c00060 4.56e-33 127.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1XEMT@135618|Methylococcales 135618|Methylococcales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_153520_2 1049564.TevJSym_be00270 1.01e-185 539.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_140416_1 1121287.AUMU01000003_gene2997 1.32e-279 777.0 28PYV@1|root,2ZCIC@2|Bacteria,4PE6Y@976|Bacteroidetes,1IEPQ@117743|Flavobacteriia,3ZPHK@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_75473_1 2340.JV46_11990 3.01e-80 257.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1J4TI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_30453_1 1423321.AS29_07385 2.08e-18 90.5 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_82513_1 1121405.dsmv_1977 2.54e-48 167.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria,2MJ2S@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_3957_2 335543.Sfum_1212 4.22e-51 176.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2MQXV@213462|Syntrophobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_192470_1 1121405.dsmv_0187 1.74e-125 374.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_96165_1 867903.ThesuDRAFT_01341 2.61e-168 488.0 COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia 186801|Clostridia L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_198493_1 1123228.AUIH01000091_gene569 1.41e-140 433.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_160276_1 335543.Sfum_0122 1.05e-114 355.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MQ7V@213462|Syntrophobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_30456_1 572480.Arnit_0902 4.34e-82 267.0 COG4206@1|root,COG4206@2|Bacteria,1QUPS@1224|Proteobacteria,43CID@68525|delta/epsilon subdivisions,2YTCZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_192474_1 1121396.KB892990_gene4478 4.63e-39 141.0 2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,42TSA@68525|delta/epsilon subdivisions,2WQKD@28221|Deltaproteobacteria,2MKS8@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative transmembrane protein (Alph_Pro_TM) - - - - - - - - - - - - Alph_Pro_TM k59_179746_1 1121405.dsmv_0054 1.45e-85 273.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MHMN@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_198498_1 913865.DOT_3301 2.87e-32 126.0 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia,260BK@186807|Peptococcaceae 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_82520_1 1121935.AQXX01000096_gene2550 3.48e-141 410.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,1S09Z@1236|Gammaproteobacteria,1XP1M@135619|Oceanospirillales 135619|Oceanospirillales KL DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_114665_1 1026882.MAMP_01027 9.11e-48 160.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,460DG@72273|Thiotrichales 72273|Thiotrichales V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_114665_2 345073.VC395_1995 1.95e-60 192.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XSNS@135623|Vibrionales 135623|Vibrionales S protein conserved in bacteria TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_50018_2 1049564.TevJSym_ab01540 3.95e-54 189.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase copA GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECO103_1326.ECO103_0460,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557 E1-E2_ATPase,HMA,Hydrolase k59_37316_1 1123073.KB899243_gene809 1.02e-12 68.9 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1XBWP@135614|Xanthomonadales 135614|Xanthomonadales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_37316_2 1049564.TevJSym_ak00770 6.02e-153 436.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1J528@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_37316_3 1249627.D779_0322 7.61e-32 117.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales 135613|Chromatiales G system, fructose subfamily IIA component - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_24253_1 717774.Marme_3267 4.18e-90 276.0 COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1XHKB@135619|Oceanospirillales 135619|Oceanospirillales E Glutathionylspermidine synthase - - 3.5.1.78,6.3.1.8 ko:K01460 ko00480,ko01100,map00480,map01100 - R01917,R01918 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CHAP,GSP_synth k59_24253_2 349521.HCH_06601 1.77e-64 205.0 COG5463@1|root,COG5463@2|Bacteria,1MXGU@1224|Proteobacteria,1RPEV@1236|Gammaproteobacteria,1XPDP@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1190) - - - - - - - - - - - - DUF1190 k59_24253_3 349521.HCH_06600 1.51e-63 197.0 COG3766@1|root,COG3766@2|Bacteria,1N14W@1224|Proteobacteria,1S3T5@1236|Gammaproteobacteria,1XQZF@135619|Oceanospirillales 135619|Oceanospirillales S Domain of Unknown Function (DUF350) - - - ko:K08989 - - - - ko00000 - - - DUF350 k59_24253_4 349521.HCH_06599 1.88e-89 269.0 28M4V@1|root,2ZAIQ@2|Bacteria,1MV1M@1224|Proteobacteria,1RZDJ@1236|Gammaproteobacteria,1XR1P@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2491) - - - - - - - - - - - - DUF2491 k59_24253_5 1279017.AQYJ01000029_gene3482 1.66e-85 267.0 COG1226@1|root,COG1226@2|Bacteria,1NT9G@1224|Proteobacteria,1RZME@1236|Gammaproteobacteria,463ZF@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ion channel VP1064 - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_147210_5 1177154.Y5S_01150 6.32e-30 115.0 COG3152@1|root,COG3152@2|Bacteria,1NBFY@1224|Proteobacteria,1SCJ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_147210_7 1201290.M902_2043 2e-179 513.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2MSQF@213481|Bdellovibrionales,2WJ7E@28221|Deltaproteobacteria 213481|Bdellovibrionales L AAA ATPase, central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_147210_8 1131553.JIBI01000070_gene1900 6.76e-216 612.0 COG1816@1|root,COG1816@2|Bacteria,1R6Q8@1224|Proteobacteria,2VNY0@28216|Betaproteobacteria 28216|Betaproteobacteria F Adenosine/AMP deaminase - - 3.5.4.4 ko:K19572 ko00230,ko01100,map00230,map01100 - R01560 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_186621_1 335543.Sfum_4042 2.8e-92 281.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,42MRB@68525|delta/epsilon subdivisions,2WIZD@28221|Deltaproteobacteria,2MQTF@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM nitrite and sulphite reductase 4Fe-4S dsrA - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_128520_1 247490.KSU1_C0876 5.87e-90 279.0 COG2270@1|root,COG2270@2|Bacteria,2J2XD@203682|Planctomycetes 203682|Planctomycetes S Vacuole effluxer Atg22 like - - - - - - - - - - - - ATG22 k59_134364_1 1238182.C882_1826 5.45e-30 122.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria,2JRKA@204441|Rhodospirillales 204441|Rhodospirillales P Na+/Pi-cotransporter - - - - - - - - - - - - Na_Pi_cotrans k59_37317_1 56780.SYN_01801 2.05e-104 319.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MQ6Y@213462|Syntrophobacterales 28221|Deltaproteobacteria H Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_50022_1 880072.Desac_0177 5.76e-37 137.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2MQ4M@213462|Syntrophobacterales 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_50022_2 945713.IALB_0328 1.78e-22 90.5 2AFHA@1|root,315HT@2|Bacteria 2|Bacteria S S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_96181_1 96561.Dole_2323 1.23e-91 280.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MIVW@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK-2 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - iAF987.Gmet_1825 AMP-binding,AMP-binding_C_2 k59_198507_1 211586.SO_0341 1.46e-77 264.0 COG2202@1|root,COG3292@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3292@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8ZG@267890|Shewanellaceae 1236|Gammaproteobacteria T Two component regulator three Y domain protein - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y k59_147458_1 596151.DesfrDRAFT_1896 6.66e-118 350.0 COG1148@1|root,COG1148@2|Bacteria,1R99M@1224|Proteobacteria,42Q2T@68525|delta/epsilon subdivisions,2WJTB@28221|Deltaproteobacteria,2MEIA@213115|Desulfovibrionales 28221|Deltaproteobacteria C FAD dependent oxidoreductase - - - - - - - - - - - - Fer4,Pyr_redox_2 k59_147458_2 1121468.AUBR01000040_gene1720 6.43e-18 83.6 COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales 186801|Clostridia C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,Pyr_redox_2 k59_101627_1 595460.RRSWK_03372 4.04e-47 174.0 COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IZND@203682|Planctomycetes 203682|Planctomycetes K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_153713_1 768671.ThimaDRAFT_3893 1.57e-52 184.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_24520_2 1121918.ARWE01000001_gene2988 1.04e-57 184.0 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,42SJ5@68525|delta/epsilon subdivisions,2WPMP@28221|Deltaproteobacteria,43UW2@69541|Desulfuromonadales 28221|Deltaproteobacteria O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_30661_1 439235.Dalk_2837 1.79e-69 223.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MI7I@213118|Desulfobacterales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_63436_1 1547445.LO80_02765 4.46e-47 162.0 COG1708@1|root,COG1708@2|Bacteria,1PWC5@1224|Proteobacteria 1224|Proteobacteria S Nucleotidyltransferase - - - ko:K07076 - - - - ko00000 - - - HEPN,NTP_transf_2 k59_186879_1 1121405.dsmv_0309 1.69e-98 294.0 COG1082@1|root,COG1082@2|Bacteria,1N95R@1224|Proteobacteria,42RAA@68525|delta/epsilon subdivisions,2WN55@28221|Deltaproteobacteria,2MJEW@213118|Desulfobacterales 28221|Deltaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_198689_1 243233.MCA0913 3.28e-46 167.0 COG2204@1|root,COG2345@1|root,COG2204@2|Bacteria,COG2345@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - GAF_2,GGDEF,HTH_8,Sigma54_activat,V4R,XylR_N k59_198689_2 1229172.JQFA01000002_gene2255 6.2e-10 57.8 COG0288@1|root,COG0288@2|Bacteria,1G4T9@1117|Cyanobacteria 1117|Cyanobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_172874_1 1176165.CAJD01000019_gene1582 3.53e-17 81.6 COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4F91E@85019|Brevibacteriaceae 201174|Actinobacteria S ATPase family associated with various cellular activities (AAA) moxR2 - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_172874_2 1249627.D779_3832 1.23e-48 176.0 COG3064@1|root,COG3064@2|Bacteria,1RINZ@1224|Proteobacteria,1S7TN@1236|Gammaproteobacteria,1WYR1@135613|Chromatiales 135613|Chromatiales M Domain of unknown function (DUF4350) - - - - - - - - - - - - DUF4350 k59_172874_3 1209072.ALBT01000023_gene4016 1.06e-79 265.0 28IAG@1|root,2Z8D2@2|Bacteria,1P5EH@1224|Proteobacteria,1RYCA@1236|Gammaproteobacteria,1FI1T@10|Cellvibrio 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF4129 k59_172874_4 1278309.KB907101_gene519 6.23e-87 268.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria,1XJ7W@135619|Oceanospirillales 135619|Oceanospirillales S membrane - - - - - - - - - - - - SpoIIM k59_44836_2 1160137.KB907307_gene122 4.78e-08 53.9 COG2044@1|root,COG2044@2|Bacteria,2HI3Q@201174|Actinobacteria,4G2MA@85025|Nocardiaceae 201174|Actinobacteria S PFAM DsrE DsrF-like family - - - - - - - - - - - - DrsE k59_111250_1 1192759.AKIB01000026_gene2169 6.45e-17 81.3 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,2K2PY@204457|Sphingomonadales 204457|Sphingomonadales Q Retinal pigment epithelial membrane protein - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_111250_2 1192759.AKIB01000017_gene1785 2.63e-69 214.0 2AIH5@1|root,318Z0@2|Bacteria,1NQHR@1224|Proteobacteria,2UPIQ@28211|Alphaproteobacteria,2K8TG@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_195263_2 1123487.KB892846_gene457 9.85e-141 412.0 COG1879@1|root,COG1879@2|Bacteria,1MUJU@1224|Proteobacteria,2VJED@28216|Betaproteobacteria 28216|Betaproteobacteria G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_143623_3 1205753.A989_11734 4.08e-54 192.0 COG0845@1|root,COG0845@2|Bacteria,1R3R4@1224|Proteobacteria,1RNSG@1236|Gammaproteobacteria,1X48M@135614|Xanthomonadales 135614|Xanthomonadales M HlyD family secretion protein - - - ko:K13408 ko04626,map04626 M00339 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1 - - Biotin_lipoyl_2,HlyD_3 k59_150195_1 933262.AXAM01000060_gene2891 2.13e-71 231.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI07@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_20396_2 1384057.CD33_11615 1.5e-06 55.1 COG1309@1|root,COG1309@2|Bacteria,1V0ZV@1239|Firmicutes,4HEVI@91061|Bacilli,3IX44@400634|Lysinibacillus 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_7555_1 411459.RUMOBE_00216 0.000776 47.8 COG0191@1|root,COG0191@2|Bacteria,1TRS4@1239|Firmicutes,24CD4@186801|Clostridia,3Y15G@572511|Blautia 186801|Clostridia G COG COG0191 Fructose tagatose bisphosphate aldolase - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_52876_1 765913.ThidrDRAFT_0563 4.06e-119 350.0 COG1748@1|root,COG1748@2|Bacteria,1QZYP@1224|Proteobacteria 1224|Proteobacteria C PFAM Methylene-tetrahydromethanopterin dehydrogenase - - - ko:K10714 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R08059 RC00202 ko00000,ko00001,ko01000 - - - Mpt_N k59_52876_3 1283300.ATXB01000001_gene1595 1.12e-81 253.0 COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,1S1PA@1236|Gammaproteobacteria,1XDU9@135618|Methylococcales 135618|Methylococcales H Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT mch GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0071704 3.5.4.27 ko:K01499 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03464 RC01870 ko00000,ko00001,ko00002,ko01000 - - - MCH k59_59392_1 1500894.JQNN01000001_gene1884 6.57e-43 145.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VICR@28216|Betaproteobacteria,478FW@75682|Oxalobacteraceae 28216|Betaproteobacteria H Aldolase/RraA - - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_59392_2 1458275.AZ34_07120 2.73e-118 345.0 COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2VIM3@28216|Betaproteobacteria,4AAJG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM amidohydrolase 2 ligJ - 4.1.1.46,4.2.1.83 ko:K10220,ko:K14333 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R00821,R04478 RC00390,RC00498 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_104661_1 287.DR97_753 3.24e-10 67.4 COG3447@1|root,COG5001@1|root,COG5002@1|root,COG3447@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase yegE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.7.65 ko:K21084 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,MASE1,PAS,PAS_3,PAS_4,PAS_9 k59_169608_3 1049564.TevJSym_bb00350 3.89e-20 83.2 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1JBM2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like k59_117774_1 335543.Sfum_3619 1.72e-141 406.0 COG0519@1|root,COG0519@2|Bacteria,1NR5X@1224|Proteobacteria,42YTH@68525|delta/epsilon subdivisions,2WUIJ@28221|Deltaproteobacteria,2MR8H@213462|Syntrophobacterales 28221|Deltaproteobacteria F GMP synthase C terminal domain - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GMP_synt_C,NAD_synthase k59_85236_1 1395571.TMS3_0124845 2.01e-86 257.0 COG0454@1|root,COG0456@2|Bacteria,1N009@1224|Proteobacteria,1S2EE@1236|Gammaproteobacteria 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_85236_2 1395571.TMS3_0124850 1.97e-48 155.0 COG4453@1|root,COG4453@2|Bacteria,1N3ZY@1224|Proteobacteria,1SDHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_85236_3 1283300.ATXB01000001_gene1740 8.21e-24 91.3 2EJ8B@1|root,33CZH@2|Bacteria,1NHW4@1224|Proteobacteria,1SIEF@1236|Gammaproteobacteria,1XGTZ@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_59395_1 96561.Dole_0477 2.11e-34 123.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2MJ2A@213118|Desulfobacterales 28221|Deltaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_59395_2 933262.AXAM01000048_gene2587 6.9e-40 139.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2WMWK@28221|Deltaproteobacteria,2MIZD@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_182639_1 857087.Metme_3409 4.76e-51 173.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1XDS1@135618|Methylococcales 135618|Methylococcales F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_27008_2 1235794.C811_01749 4.82e-16 81.3 COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4CVWZ@84998|Coriobacteriia 84998|Coriobacteriia S IA, variant 3 - - 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 k59_27008_3 1485544.JQKP01000014_gene1900 8.98e-116 337.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,44UZN@713636|Nitrosomonadales 28216|Betaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_27008_4 1049564.TevJSym_ad01370 1.75e-166 478.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1J4NS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_20414_1 1049564.TevJSym_aj00330 1.34e-139 403.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1J574@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_20414_2 1123073.KB899241_gene3204 2.19e-23 100.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales 135614|Xanthomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_111260_2 1232410.KI421424_gene1692 1.86e-123 366.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,43V05@69541|Desulfuromonadales 28221|Deltaproteobacteria E Methylenetetrahydrofolate reductase metF-1 - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_85242_1 1265505.ATUG01000001_gene3567 3.59e-121 357.0 COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MI7W@213118|Desulfobacterales 28221|Deltaproteobacteria C CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD,FeS k59_163107_1 1134474.O59_000014 1.8e-132 389.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1FFVN@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4669 UbiD k59_91747_1 396588.Tgr7_2009 4.57e-86 261.0 COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales 135613|Chromatiales L PFAM HhH-GPD - - - ko:K07457 - - - - ko00000 - - - HhH-GPD k59_176013_1 391625.PPSIR1_17000 1.07e-61 221.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2YTZK@29|Myxococcales 28221|Deltaproteobacteria CE Peptidase family M1 domain pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,HEAT_2,Peptidase_M1 k59_39911_1 395494.Galf_1894 1.74e-45 157.0 COG3258@1|root,COG3258@2|Bacteria,1NA2I@1224|Proteobacteria,2W47C@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c - - - - - - - - - - - - CCP_MauG k59_52884_1 1234409.C683_0821 1.46e-16 80.5 COG1705@1|root,COG1705@2|Bacteria,1V7JY@1239|Firmicutes,4HIY4@91061|Bacilli,4AZN5@81852|Enterococcaceae 91061|Bacilli NU Lysozyme subfamily 2 acmA - 3.2.1.17,3.2.1.96 ko:K01185,ko:K01227 ko00511,map00511 - - - ko00000,ko00001,ko01000 - - - Glucosaminidase,SH3_8,YceG k59_46324_1 2340.JV46_12870 1.49e-137 398.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,1JB29@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like k59_46324_2 1123400.KB904768_gene3403 1.14e-33 124.0 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,1RYH6@1236|Gammaproteobacteria,45ZY6@72273|Thiotrichales 72273|Thiotrichales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_163108_1 349124.Hhal_0675 1.83e-40 142.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_163108_2 572477.Alvin_2756 9.09e-58 187.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_124215_4 1049564.TevJSym_ac00960 4.9e-109 317.0 COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,1J5QJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA rlmG - 2.1.1.174 ko:K11391 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS k59_46326_1 1167006.UWK_01207 3.92e-12 67.8 COG3005@1|root,COG3005@2|Bacteria,1RJ3G@1224|Proteobacteria,42ST3@68525|delta/epsilon subdivisions 1224|Proteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_NNT,Cytochrome_C7 k59_46326_2 1167006.UWK_01206 1.34e-36 133.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria,2MNMB@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_4 k59_65815_1 572477.Alvin_0815 1.51e-121 359.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1X2FT@135613|Chromatiales 135613|Chromatiales S PFAM Aminoglycoside phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_65815_2 1049564.TevJSym_ak00920 9.67e-92 284.0 COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,1RZ26@1236|Gammaproteobacteria,1JAGM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_39916_1 1163617.SCD_n01242 4.31e-92 288.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_104679_1 688269.Theth_1685 8.04e-34 123.0 28JE3@1|root,2Z98B@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - AbiEii k59_137143_1 765913.ThidrDRAFT_0573 3.32e-88 272.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_72371_1 177437.HRM2_34570 1.46e-62 205.0 COG0477@1|root,COG2814@2|Bacteria,1R9V9@1224|Proteobacteria,42Q1C@68525|delta/epsilon subdivisions,2WK7P@28221|Deltaproteobacteria,2MMQA@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_59483_1 518766.Rmar_2140 1.2e-68 219.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,4NS7V@976|Bacteroidetes 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_111363_1 1049564.TevJSym_ae00370 7.81e-61 200.0 2E9CV@1|root,333KG@2|Bacteria,1NT11@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_7660_1 857087.Metme_3258 4.75e-112 350.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_4025 PEPcase k59_195347_1 1255043.TVNIR_1249 2.1e-33 127.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RR5N@1236|Gammaproteobacteria,1X0AA@135613|Chromatiales 135613|Chromatiales S TIGRFAM HipA N-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_195347_2 1283300.ATXB01000002_gene2968 4.35e-26 98.6 COG1396@1|root,COG1396@2|Bacteria,1NGQR@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - ko:K15773 - - - - ko00000,ko02048,ko03000 - - - HTH_3,HTH_31 k59_91855_2 533247.CRD_00252 9.83e-27 102.0 COG1941@1|root,COG1941@2|Bacteria,1G2I6@1117|Cyanobacteria,1HJ2T@1161|Nostocales 1117|Cyanobacteria C PFAM NADH ubiquinone oxidoreductase, 20 hoxY - 1.12.1.2 ko:K18007 - - - - ko00000,ko01000 - - iJN678.hoxY Oxidored_q6 k59_143774_1 1121085.AUCI01000026_gene2280 1.2e-30 112.0 COG0640@1|root,COG0640@2|Bacteria,1VJC2@1239|Firmicutes 1239|Firmicutes K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_20,HTH_5 k59_143774_2 396588.Tgr7_0251 6.97e-134 386.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_111366_1 1433126.BN938_2649 6.85e-61 199.0 2DM9D@1|root,328C5@2|Bacteria,4NPRC@976|Bacteroidetes,2FRTC@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_46448_1 439235.Dalk_0247 5.02e-67 229.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_202173_1 1121405.dsmv_1659 1.74e-20 84.7 COG3197@1|root,COG3197@2|Bacteria,1P4MU@1224|Proteobacteria,432XF@68525|delta/epsilon subdivisions,2WYHY@28221|Deltaproteobacteria,2MPDK@213118|Desulfobacterales 28221|Deltaproteobacteria P Cytochrome oxidase maturation protein - - - - - - - - - - - - - k59_202173_2 1121405.dsmv_1660 6.57e-22 92.0 COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2WNX9@28221|Deltaproteobacteria,2MKZC@213118|Desulfobacterales 28221|Deltaproteobacteria C cytochrome C oxidase mono-heme subunit FixO - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixO k59_176124_1 326442.PSHAa0766 7.67e-65 208.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,2Q04Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG0835 Chemotaxis signal transduction protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_176124_2 1049564.TevJSym_aa01200 1.02e-44 154.0 COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1J6IH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly flgA - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_85342_1 1049564.TevJSym_bd00140 2.54e-82 272.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_150330_1 667014.Thein_0197 1.54e-32 117.0 COG1959@1|root,COG1959@2|Bacteria,2GGXM@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_150330_2 1304872.JAGC01000003_gene2442 1.26e-05 50.4 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42N5I@68525|delta/epsilon subdivisions,2WM5T@28221|Deltaproteobacteria,2M9FV@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_31 k59_33527_1 323261.Noc_0223 1.97e-153 444.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_182754_2 1307761.L21SP2_3206 6.25e-94 290.0 COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes 203691|Spirochaetes M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_189178_2 1001530.BACE01000011_gene2248 4.19e-38 129.0 COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,1S9N8@1236|Gammaproteobacteria,1XXP3@135623|Vibrionales 135623|Vibrionales S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_13907_1 1123376.AUIU01000016_gene222 9.05e-99 307.0 COG1053@1|root,COG1053@2|Bacteria,3J0ZM@40117|Nitrospirae 40117|Nitrospirae C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_27093_1 1499685.CCFJ01000051_gene2024 8.83e-05 51.2 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4IS9Q@91061|Bacilli,1ZS3W@1386|Bacillus 91061|Bacilli M Male sterility protein galE3 - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_72390_1 644282.Deba_2183 1.62e-153 466.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_189184_1 243233.MCA2857 8.89e-07 53.1 COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,1S19G@1236|Gammaproteobacteria,1XEVQ@135618|Methylococcales 135618|Methylococcales C TIGRFAM formylmethanofuran dehydrogenase subunit C - - 1.2.7.12 ko:K00202 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - GXGXG k59_40041_1 1121413.JMKT01000009_gene2175 7.05e-65 201.0 COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,42S64@68525|delta/epsilon subdivisions,2WNPP@28221|Deltaproteobacteria,2MHHM@213115|Desulfovibrionales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_112769_1 666681.M301_1708 5.31e-19 86.7 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2VIV1@28216|Betaproteobacteria,2KKP1@206350|Nitrosomonadales 206350|Nitrosomonadales N Flagellar basal body rod - - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_112769_2 983545.Glaag_1236 5.92e-37 136.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,1RPZI@1236|Gammaproteobacteria,465SG@72275|Alteromonadaceae 1236|Gammaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_112769_4 472759.Nhal_2324 1.25e-35 126.0 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,1WYJC@135613|Chromatiales 135613|Chromatiales N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body - - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_15191_1 177437.HRM2_43010 1.76e-116 343.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MIBF@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_54324_2 640081.Dsui_3297 3.61e-81 248.0 COG0778@1|root,COG0778@2|Bacteria,1N95W@1224|Proteobacteria,2VQKR@28216|Betaproteobacteria,2KW6E@206389|Rhodocyclales 206389|Rhodocyclales C Nitroreductase family - - 1.5.1.34 ko:K10679 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Nitroreductase k59_112921_1 944481.JAFP01000001_gene564 7.91e-73 239.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M6BJ@213113|Desulfurellales 28221|Deltaproteobacteria NU Type II secretion system protein E pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_61130_1 1168067.JAGP01000001_gene590 1.6e-51 176.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,1S416@1236|Gammaproteobacteria,4616F@72273|Thiotrichales 72273|Thiotrichales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_177885_1 644282.Deba_2226 4.83e-114 366.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Pyr_redox_2 k59_171442_1 211586.SO_2192 4.27e-41 155.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,2QABE@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_9259_2 563040.Saut_2063 9.87e-05 43.9 COG3462@1|root,COG3462@2|Bacteria,1Q6M9@1224|Proteobacteria,432UC@68525|delta/epsilon subdivisions,2YSNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane protein (DUF2078) - - - ko:K08982 - - - - ko00000 - - - - k59_22342_2 745014.OMB55_00010690 3.54e-34 123.0 COG4508@1|root,COG4508@2|Bacteria,1RAX1@1224|Proteobacteria,1RYFG@1236|Gammaproteobacteria,1J5W3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S dUTPase dut - - - - - - - - - - - dUTPase_2 k59_106281_1 1192759.AKIB01000069_gene3857 5.42e-100 291.0 2EN4R@1|root,33FSS@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_106281_2 1522072.IL54_1435 1.98e-142 426.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1R7EM@1224|Proteobacteria,2UPM6@28211|Alphaproteobacteria,2K9IJ@204457|Sphingomonadales 204457|Sphingomonadales C PQQ-like domain - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ k59_126263_2 1235788.C802_00656 5.65e-22 97.4 COG1166@1|root,COG1166@2|Bacteria,4PKX0@976|Bacteroidetes,2FMN2@200643|Bacteroidia,4AN1Q@815|Bacteroidaceae 976|Bacteroidetes H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_132674_1 247490.KSU1_D0297 5.58e-107 325.0 COG0438@1|root,COG0438@2|Bacteria,2J10U@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_86933_1 335659.S23_34490 5.87e-13 68.9 COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,2TTH6@28211|Alphaproteobacteria,3JUP4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1,Lactonase,NHL k59_86933_3 1125973.JNLC01000014_gene2456 4.73e-30 118.0 2C1VZ@1|root,32R98@2|Bacteria,1RJ8X@1224|Proteobacteria,2UEV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_86933_4 391165.GbCGDNIH1_1925 6.92e-22 91.3 2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2UC0T@28211|Alphaproteobacteria,2JU3A@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_138529_1 1265505.ATUG01000001_gene4101 0.000365 43.1 COG3209@1|root,COG3266@1|root,COG3209@2|Bacteria,COG3266@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM RHS repeat-associated core - - - - - - - - - - - - AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS k59_93863_2 1396858.Q666_09495 3.24e-57 178.0 COG3077@1|root,COG3077@2|Bacteria,1N2J9@1224|Proteobacteria,1S9U9@1236|Gammaproteobacteria,46B5B@72275|Alteromonadaceae 1236|Gammaproteobacteria L RelB antitoxin dinJ - - ko:K07473 - - - - ko00000,ko02048 - - - RelB k59_67527_1 933262.AXAM01000001_gene351 3.07e-88 276.0 COG0457@1|root,COG0457@2|Bacteria,1RCWA@1224|Proteobacteria,42RIH@68525|delta/epsilon subdivisions,2WNE2@28221|Deltaproteobacteria,2MJRW@213118|Desulfobacterales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_106283_1 1049564.TevJSym_am00190 8.24e-43 148.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1J5GD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0282,ic_1306.c0493 F420_oxidored,P5CR_dimer k59_106283_2 1049564.TevJSym_am00180 1.83e-30 112.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_61133_1 768671.ThimaDRAFT_4305 2.18e-72 227.0 COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,1WWK9@135613|Chromatiales 135613|Chromatiales C NADH dehydrogenase - - - - - - - - - - - - NADHdh k59_61133_2 1249627.D779_3681 6.2e-263 738.0 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1WW1W@135613|Chromatiales 135613|Chromatiales CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_28599_1 96561.Dole_2003 1.03e-80 250.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MIPS@213118|Desulfobacterales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_196763_1 765912.Thimo_1919 3.46e-97 298.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_196763_2 983545.Glaag_0453 8.05e-143 410.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,464V0@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the peptidase M48B family htpX GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_151904_1 1452718.JBOY01000136_gene1453 1.3e-93 300.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_22348_1 744872.Spica_2486 7.12e-62 204.0 COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes 203691|Spirochaetes M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_145507_1 159087.Daro_2718 8.21e-83 273.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales 206389|Rhodocyclales CM Acyl-CoA synthetase (NDP forming) - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_138533_1 765913.ThidrDRAFT_0447 5.02e-55 182.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1WWXV@135613|Chromatiales 135613|Chromatiales IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short k59_119740_1 1049564.TevJSym_at00710 4.92e-104 305.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1J5UE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_119740_2 1049564.TevJSym_at00720 9.07e-56 176.0 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,1SAZP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P hemerythrin-like metal-binding - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_196765_2 243231.GSU2763 4.02e-41 140.0 COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,42WI7@68525|delta/epsilon subdivisions,2WSAF@28221|Deltaproteobacteria,43VM2@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF1003) - - - - - - - - - - - - DUF1003 k59_112942_1 96561.Dole_1952 4.01e-93 278.0 COG1830@1|root,COG1830@2|Bacteria,1MWJW@1224|Proteobacteria,42NP9@68525|delta/epsilon subdivisions,2WIP9@28221|Deltaproteobacteria,2MIJY@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids aroA' - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_48041_1 765910.MARPU_02955 1.48e-30 113.0 28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,1RS8I@1236|Gammaproteobacteria,1WWZ9@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_48041_2 323848.Nmul_A0024 1.06e-33 125.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,3735H@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Smr protein MutS2 smrA - - - - - - - - - - - Smr k59_48041_3 1049564.TevJSym_au00580 8.83e-140 400.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1J5TA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - iSFxv_1172.SFxv_3035 SurE k59_48041_4 1049564.TevJSym_au00590 1.77e-112 328.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1J5GV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_48041_5 765912.Thimo_1331 1.36e-91 273.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,1WY8B@135613|Chromatiales 135613|Chromatiales S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_48041_6 1245471.PCA10_45040 6.32e-52 178.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1YE6T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Peptidase family M23 nlpD GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944 - ko:K06194,ko:K12943 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_48041_7 1049564.TevJSym_au00620 3.32e-102 304.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1J4VY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0568 DNA-directed RNA polymerase, sigma subunit rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_184561_2 78245.Xaut_0499 1.71e-06 51.6 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_80679_1 765912.Thimo_2071 1.1e-52 175.0 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,1WW83@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_86943_1 1123376.AUIU01000013_gene1780 2.28e-66 216.0 COG0421@1|root,COG0421@2|Bacteria,3J0Y5@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_42053_3 765911.Thivi_4466 7.78e-23 99.0 28PZQ@1|root,2ZCIX@2|Bacteria,1RA7M@1224|Proteobacteria,1S25R@1236|Gammaproteobacteria,1WY1B@135613|Chromatiales 135613|Chromatiales S EF hand - - - - - - - - - - - - EF-hand_5 k59_42053_4 1121935.AQXX01000142_gene2315 0.0 1078.0 COG1240@1|root,COG1240@2|Bacteria,1R4IW@1224|Proteobacteria,1SN40@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - - - - - - - - - - - - k59_42053_5 1049564.TevJSym_ab00790 4.23e-123 372.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1J85K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_42053_6 2340.JV46_08940 5.06e-73 224.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1S0IN@1236|Gammaproteobacteria,1JA2Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulatory protein, C terminal IV02_26825 - - - - - - - - - - - Response_reg,Trans_reg_C k59_73695_1 232721.Ajs_4264 2.69e-105 333.0 COG3846@1|root,COG3846@2|Bacteria,1MVFD@1224|Proteobacteria,2VKAJ@28216|Betaproteobacteria,4AAAD@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM TrbL VirB6 plasmid conjugal transfer protein trbL - - ko:K07344 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - TrbL k59_73695_2 1380387.JADM01000011_gene3555 6.8e-26 97.8 2E16U@1|root,32VIU@2|Bacteria,1N1CS@1224|Proteobacteria,1SA5M@1236|Gammaproteobacteria,1XPTX@135619|Oceanospirillales 135619|Oceanospirillales S Toxin of toxin-antitoxin type 1 system - - - - - - - - - - - - ptaRNA1_toxin k59_73695_5 1280952.HJA_05792 3.82e-124 367.0 28JYP@1|root,2Z9NV@2|Bacteria,1R4A0@1224|Proteobacteria,2TVGF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S RES domain - - - - - - - - - - - - RES k59_73695_6 1280952.HJA_05797 1.84e-136 396.0 28MN3@1|root,2ZAXQ@2|Bacteria,1R4C0@1224|Proteobacteria,2TXFR@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_73695_7 1266925.JHVX01000001_gene2772 1.51e-110 329.0 2DB92@1|root,2Z7UD@2|Bacteria,1P1QQ@1224|Proteobacteria,2VUM0@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_158236_2 1123401.JHYQ01000017_gene2570 2.36e-75 236.0 COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,1RZ3N@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Pfam Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_164636_1 2340.JV46_24700 7.61e-26 98.2 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1JAXW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_164636_2 1049564.TevJSym_aw00360 5.43e-71 218.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1J8B0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfur oxidation protein SoxY soxY - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_93880_1 323261.Noc_1294 1.57e-281 776.0 28JM7@1|root,2Z9DS@2|Bacteria,1R8QS@1224|Proteobacteria,1S1P5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_67549_1 46234.ANA_C13142 5.14e-84 264.0 COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales 1117|Cyanobacteria L PFAM Transposase DDE domain - - - ko:K07495 - - - - ko00000 - - - DDE_5,DDE_Tnp_1 k59_196773_1 1321778.HMPREF1982_04524 1.55e-42 145.0 COG3467@1|root,COG3467@2|Bacteria,1V7MR@1239|Firmicutes,25B09@186801|Clostridia 186801|Clostridia S pyridoxamine 5-phosphate - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_28748_1 1049564.TevJSym_bl00170 1.94e-132 384.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1J4V1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could regulate a protease hflC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_28748_3 1049564.TevJSym_bl00190 1.82e-230 643.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_196896_1 765911.Thivi_1138 4.85e-33 120.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales 135613|Chromatiales I PFAM CDP-alcohol phosphatidyltransferase - - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_203780_1 197221.22295809 1.83e-20 94.0 COG1721@1|root,COG1721@2|Bacteria,1G1DK@1117|Cyanobacteria 1117|Cyanobacteria S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_126524_1 471223.GWCH70_3145 3.62e-257 713.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1WES5@129337|Geobacillus 91061|Bacilli C Belongs to the aldehyde dehydrogenase family acoD - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_184716_1 439235.Dalk_1964 8.41e-36 133.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_113054_1 1049564.TevJSym_ar00370 9.32e-22 94.0 COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,1SBMD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - - k59_69571_1 1121405.dsmv_2612 2.72e-103 310.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MJ2T@213118|Desulfobacterales 28221|Deltaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_121836_2 1348114.OM33_15565 9.36e-47 171.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,2Q35U@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_11040_1 1117958.PE143B_0121285 3.26e-132 439.0 COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II pvdL - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_11040_2 1117318.PRUB_06620 5.45e-101 308.0 COG2175@1|root,COG2175@2|Bacteria,1MWQ6@1224|Proteobacteria,1RP8I@1236|Gammaproteobacteria,2Q0MN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family syrP - - - - - - - - - - - TauD k59_11040_3 1894.JOER01000039_gene1298 0.000378 47.4 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Bac_luciferase,Condensation,PP-binding,Thioesterase k59_153366_1 1089553.Tph_c06620 1.15e-27 106.0 2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes,24SN5@186801|Clostridia,42HH1@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - k59_37119_1 765911.Thivi_3989 5.19e-31 116.0 COG1394@1|root,COG1394@2|Bacteria,1RJCN@1224|Proteobacteria,1S7QV@1236|Gammaproteobacteria,1WY6C@135613|Chromatiales 135613|Chromatiales C subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_37119_2 1049564.TevJSym_aa02390 8.18e-13 67.8 COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_186450_1 443143.GM18_0572 3.3e-21 95.1 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42P32@68525|delta/epsilon subdivisions,2WM9Q@28221|Deltaproteobacteria,43URZ@69541|Desulfuromonadales 28221|Deltaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6 k59_49817_1 765913.ThidrDRAFT_0594 2.86e-92 281.0 COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,1S435@1236|Gammaproteobacteria,1X1UQ@135613|Chromatiales 135613|Chromatiales S Sulphur oxidation protein SoxZ - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,SoxZ k59_134187_1 1049564.TevJSym_ax00280 2.73e-87 266.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1J4QH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Permease perM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_166206_1 1297742.A176_02571 7e-41 149.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria 1224|Proteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains actB - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_101207_2 118163.Ple7327_3996 3.38e-61 198.0 COG2334@1|root,COG2334@2|Bacteria,1G1QD@1117|Cyanobacteria,3VHR8@52604|Pleurocapsales 1117|Cyanobacteria S PFAM Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_172629_1 1049564.TevJSym_an00220 8.99e-103 306.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1J4J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_172629_2 870187.Thini_0399 1.54e-34 129.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,4609K@72273|Thiotrichales 72273|Thiotrichales E Aminotransferase class-V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_44369_2 395493.BegalDRAFT_2635 9.23e-31 119.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,45ZW6@72273|Thiotrichales 72273|Thiotrichales J ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_198357_1 1123073.KB899243_gene629 4.2e-08 51.6 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1X61R@135614|Xanthomonadales 135614|Xanthomonadales J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_198357_2 1517416.IDAT_09525 5.93e-55 184.0 COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,1RY3J@1236|Gammaproteobacteria,2QG2T@267893|Idiomarinaceae 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_198357_3 1122951.ATUE01000005_gene2134 1.98e-87 266.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,3NKH2@468|Moraxellaceae 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_128603_2 317619.ANKN01000120_gene754 6.65e-28 114.0 COG0482@1|root,COG0482@2|Bacteria,1G21J@1117|Cyanobacteria,1MM15@1212|Prochloraceae 1117|Cyanobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_69872_2 529507.PMI0762 9.01e-24 107.0 2DMJQ@1|root,32S16@2|Bacteria,1N4SH@1224|Proteobacteria,1SZVV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_37402_1 765913.ThidrDRAFT_0573 2.59e-109 331.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_37402_2 243233.MCA2869 8.84e-23 98.2 COG1548@1|root,COG1548@2|Bacteria,1RAMA@1224|Proteobacteria,1S26G@1236|Gammaproteobacteria,1XDXI@135618|Methylococcales 135618|Methylococcales GK PFAM Hydantoinase oxoprolinase - - - - - - - - - - - - Hydantoinase_A k59_153623_1 335543.Sfum_1034 3.77e-99 300.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,42MTI@68525|delta/epsilon subdivisions,2WIXW@28221|Deltaproteobacteria,2MR88@213462|Syntrophobacterales 28221|Deltaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_198568_1 317655.Sala_2168 1.1e-52 178.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2K3IJ@204457|Sphingomonadales 204457|Sphingomonadales L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_128604_1 439235.Dalk_3802 7.61e-121 352.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria,2MK8B@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_50086_3 1123248.KB893316_gene4600 3.51e-11 75.1 COG1749@1|root,COG3055@1|root,COG1749@2|Bacteria,COG3055@2|Bacteria,4NTUT@976|Bacteroidetes 976|Bacteroidetes N Domain of unknown function (DUF4082) - - - - - - - - - - - - Cu-binding_MopE,DUF4082 k59_82615_1 748247.AZKH_0602 3.05e-119 345.0 COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,2W5PJ@28216|Betaproteobacteria 28216|Betaproteobacteria L Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_82615_2 765914.ThisiDRAFT_1446 2.17e-90 281.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_186737_3 1049564.TevJSym_aa00520 1.97e-56 177.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1J6G6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_63300_1 667014.Thein_1033 4.35e-74 234.0 COG1060@1|root,COG1060@2|Bacteria,2GH1Z@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1 ko:K11784 ko00130,ko01110,map00130,map01110 - R08588 RC02329 ko00000,ko00001,ko01000 - - - Radical_SAM k59_179847_1 589865.DaAHT2_1753 1.05e-84 270.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MN6X@213118|Desulfobacterales 28221|Deltaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_30554_1 1232437.KL662077_gene1944 9.31e-66 219.0 COG4191@1|root,COG5278@1|root,COG4191@2|Bacteria,COG5278@2|Bacteria,1MY5P@1224|Proteobacteria,42MTA@68525|delta/epsilon subdivisions,2WJ9Q@28221|Deltaproteobacteria,2MIRX@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - 4HB_MCP_1,CHASE3,HAMP,HATPase_c,HisKA k59_134457_1 502025.Hoch_1870 1.55e-68 233.0 COG3303@1|root,COG3303@2|Bacteria,1QXPE@1224|Proteobacteria 1224|Proteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process cbcM - - - - - - - - - - - Cytochrome_C554 k59_160377_1 1120797.KB908262_gene2960 1.41e-10 67.0 COG1716@1|root,COG3629@1|root,COG1716@2|Bacteria,COG3629@2|Bacteria,2GKKQ@201174|Actinobacteria,233XG@1762|Mycobacteriaceae 201174|Actinobacteria K involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb - - - - - - - - - - - - AAA_16,BTAD,FHA,Trans_reg_C k59_153625_1 697281.Mahau_1153 3.08e-22 99.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales 186801|Clostridia C Part of a membrane complex involved in electron transport rnfC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB k59_140523_1 1121405.dsmv_2066 4.08e-59 194.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MHTU@213118|Desulfobacterales 28221|Deltaproteobacteria E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_140523_2 1121918.ARWE01000001_gene1367 1.05e-120 357.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,43T0Y@69541|Desulfuromonadales 28221|Deltaproteobacteria E Pyridoxal-dependent decarboxylase, C-terminal sheet domain lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_101503_1 420662.Mpe_A2763 2.05e-68 230.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KJ0P@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_101503_2 765910.MARPU_16385 3.39e-107 324.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales 135613|Chromatiales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_205429_1 1112216.JH594426_gene3799 5.01e-112 343.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - - - - - - - - - - rve k59_30559_1 1207063.P24_01460 9.49e-53 187.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2TQJW@28211|Alphaproteobacteria,2JPZU@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narZ - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_147315_1 1049564.TevJSym_aw00380 5.68e-30 111.0 2ER47@1|root,33IPS@2|Bacteria,1NHAY@1224|Proteobacteria 1224|Proteobacteria S chemotaxis protein - - - - - - - - - - - - DUF2802 k59_147315_3 1268239.PALB_5530 3.32e-67 208.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1SYDF@1236|Gammaproteobacteria,2Q0Q7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NT COG0835 Chemotaxis signal transduction protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_147315_4 1049564.TevJSym_aw00400 1.12e-28 114.0 COG0835@1|root,COG0835@2|Bacteria,1MYHY@1224|Proteobacteria,1S2TC@1236|Gammaproteobacteria,1J6XW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Two component signalling adaptor domain VP2226 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_128611_1 880072.Desac_1856 1.53e-41 149.0 COG0476@1|root,COG0476@2|Bacteria 2|Bacteria H Involved in molybdopterin and thiamine biosynthesis, family 2 - - - - - - - - - - - - ThiF k59_205431_1 439235.Dalk_1001 7.56e-59 192.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2WJB5@28221|Deltaproteobacteria,2MIVC@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the ParA family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA k59_186745_1 439235.Dalk_0409 1.25e-122 362.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_166455_2 316274.Haur_3477 5.36e-67 246.0 COG2909@1|root,COG2909@2|Bacteria,2G7Q4@200795|Chloroflexi,3754G@32061|Chloroflexia 32061|Chloroflexia K ATP-dependent transcriptional regulator, MalT-like, LuxR family - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_179858_1 1121438.JNJA01000007_gene1688 3.01e-35 128.0 COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2M8YK@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_50096_1 997352.HMPREF9419_0979 0.000956 47.4 COG1076@1|root,COG1076@2|Bacteria,4NF1B@976|Bacteroidetes,2FQ12@200643|Bacteroidia 976|Bacteroidetes O DnaJ domain protein - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_50096_2 335543.Sfum_0752 1.48e-21 94.7 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_192587_1 880072.Desac_0816 2.84e-79 249.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_17 k59_82629_2 1232437.KL661955_gene2368 6.41e-68 221.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42P90@68525|delta/epsilon subdivisions,2WK8R@28221|Deltaproteobacteria,2MI3H@213118|Desulfobacterales 28221|Deltaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_30564_1 96561.Dole_1980 6.03e-80 248.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,2MIPV@213118|Desulfobacterales 28221|Deltaproteobacteria OU signal peptide peptidase SppA sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_122143_1 439235.Dalk_4891 6.72e-143 420.0 COG2303@1|root,COG2303@2|Bacteria,1QC41@1224|Proteobacteria,43E7D@68525|delta/epsilon subdivisions,2WZX2@28221|Deltaproteobacteria,2MN26@213118|Desulfobacterales 28221|Deltaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_101515_1 103690.17130955 2.01e-78 246.0 COG1902@1|root,COG1902@2|Bacteria,1FZYT@1117|Cyanobacteria,1HJXU@1161|Nostocales 1117|Cyanobacteria C PFAM NADH flavin oxidoreductase NADH oxidase - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_11342_1 671143.DAMO_3061 5.49e-37 139.0 COG0795@1|root,COG0795@2|Bacteria 2|Bacteria M lipopolysaccharide-transporting ATPase activity lptG - - ko:K07091,ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_114774_2 686578.AFFX01000011_gene2665 1.13e-21 90.1 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the UPF0102 family yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_114774_3 1049564.TevJSym_aj00440 3.5e-153 455.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1J4Z4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M lipoprotein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_37422_1 525897.Dbac_2289 2.96e-39 147.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MAT9@213115|Desulfovibrionales 28221|Deltaproteobacteria T SMART ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_108591_1 1444306.JFZC01000034_gene2697 8.81e-27 107.0 COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,4HFMW@91061|Bacilli,26NVJ@186821|Sporolactobacillaceae 91061|Bacilli O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_179861_1 529507.PMI1120 3.95e-14 82.4 COG3209@1|root,COG4104@1|root,COG3209@2|Bacteria,COG4104@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3Z39C@583|Proteus 1236|Gammaproteobacteria M RHS protein - - - - - - - - - - - - DUF4150,PAAR_motif,RHS,RHS_repeat,Tox-HNH-EHHH k59_55967_1 550540.Fbal_1194 3.98e-63 201.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type spermidine putrescine transport system, permease component II potC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351 - ko:K11070,ko:K11074 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - iSBO_1134.SBO_1939 BPD_transp_1 k59_55967_2 870187.Thini_0479 5.61e-121 352.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,460H1@72273|Thiotrichales 72273|Thiotrichales P Putrescine transport system permease potH - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_101516_1 595494.Tola_3171 6.89e-24 102.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1Y5F6@135624|Aeromonadales 135624|Aeromonadales IQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_101516_2 749222.Nitsa_0768 9.08e-60 196.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42NK6@68525|delta/epsilon subdivisions,2YMCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_179865_1 946235.CAER01000060_gene3266 4.74e-05 45.4 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,4HA8Q@91061|Bacilli,23ITH@182709|Oceanobacillus 91061|Bacilli T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_44730_1 335543.Sfum_3100 3.05e-40 149.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales 28221|Deltaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_140547_1 1121889.AUDM01000005_gene1758 3.44e-76 241.0 COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1HX9D@117743|Flavobacteriia,2P01U@237|Flavobacterium 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH k59_75594_1 439235.Dalk_4346 1.15e-61 200.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIA8@213118|Desulfobacterales 28221|Deltaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_75594_2 1232437.KL661988_gene288 6.97e-76 234.0 COG1813@1|root,COG1917@1|root,COG1813@2|Bacteria,COG1917@2|Bacteria,1R8QC@1224|Proteobacteria,42NJP@68525|delta/epsilon subdivisions,2WMAB@28221|Deltaproteobacteria,2MIRS@213118|Desulfobacterales 28221|Deltaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_88888_1 335543.Sfum_1905 8.38e-114 338.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2MQTX@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_142920_1 335543.Sfum_0151 7.7e-65 214.0 COG0500@1|root,COG1216@1|root,COG1216@2|Bacteria,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,NTP_transf_5 k59_6878_1 521000.PROVRETT_06008 5.4e-48 177.0 28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,1RQIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_110561_1 96561.Dole_0235 1.22e-61 198.0 COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria,2MJ8J@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_6880_1 186497.PF0631 6.49e-14 78.6 COG1180@1|root,arCOG00936@2157|Archaea,2XX51@28890|Euryarchaeota,242Z7@183968|Thermococci 183968|Thermococci O 4Fe-4S single cluster domain - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_149475_1 700598.Niako_2442 1.26e-10 67.4 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1IR3V@117747|Sphingobacteriia 976|Bacteroidetes T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_52209_1 1304888.ATWF01000001_gene1470 1.48e-16 82.8 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2GFDI@200930|Deferribacteres 2|Bacteria T HD domain - - - - - - - - - - - - DUF3369,GAF,GAF_2,HD,PAS_3,PAS_9,Response_reg k59_78270_1 693986.MOC_5615 2.23e-06 48.5 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,1JRBM@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_65140_1 998088.B565_1898 6.48e-33 126.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1Y43H@135624|Aeromonadales 135624|Aeromonadales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_188343_1 933262.AXAM01000034_gene1559 1.45e-60 205.0 COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales 28221|Deltaproteobacteria T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_26344_1 228410.NE2238 5.23e-81 242.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2VTIQ@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_110566_1 926692.AZYG01000070_gene1685 6.01e-21 93.2 COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,3WC4G@53433|Halanaerobiales 186801|Clostridia E vitamin B12 dependent methionine synthase, activation metH2 - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Met_synt_B12 k59_110566_2 903814.ELI_0487 1.87e-18 84.7 COG1410@1|root,COG1410@2|Bacteria,1UV7K@1239|Firmicutes,25CEH@186801|Clostridia 186801|Clostridia E PFAM Pterin binding enzyme - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_65147_1 1304885.AUEY01000001_gene3242 6.92e-21 85.1 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MKFE@213118|Desulfobacterales 28221|Deltaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_65147_2 1121405.dsmv_3585 5.31e-52 164.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MKPD@213118|Desulfobacterales 28221|Deltaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_188345_1 1229172.JQFA01000004_gene901 2.13e-22 92.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales 1117|Cyanobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_188345_2 553385.JEMF01000050_gene2164 1.89e-38 136.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,1XJVW@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - DUF924 k59_52217_1 713586.KB900536_gene890 1.98e-148 424.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales 135613|Chromatiales L PFAM integrase - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_52217_2 713586.KB900536_gene1521 6.76e-43 142.0 COG2963@1|root,COG2963@2|Bacteria,1N3E0@1224|Proteobacteria,1S9T7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2963 Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_188346_1 1049564.TevJSym_az00090 1.16e-147 421.0 COG3301@1|root,COG3301@2|Bacteria,1MXQ9@1224|Proteobacteria,1RQIT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P reductase nrfD - - ko:K04015 - - - - ko00000 - - - NrfD k59_155940_2 1265313.HRUBRA_00751 8.69e-50 159.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1J66K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_155940_3 1198232.CYCME_1813 3.81e-11 63.5 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,45ZNZ@72273|Thiotrichales 72273|Thiotrichales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_413_1 351348.Maqu_2390 2.76e-170 492.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_130065_1 909663.KI867150_gene213 3.77e-60 207.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_110573_1 335543.Sfum_1830 1.93e-103 315.0 COG3581@1|root,COG3581@2|Bacteria,1N1N8@1224|Proteobacteria,42UB7@68525|delta/epsilon subdivisions,2WQ9V@28221|Deltaproteobacteria 28221|Deltaproteobacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k59_19800_1 768671.ThimaDRAFT_2779 1.68e-74 234.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WXNS@135613|Chromatiales 135613|Chromatiales S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 k59_13315_1 1286106.MPL1_02673 3.37e-126 407.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,45ZUQ@72273|Thiotrichales 72273|Thiotrichales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_13315_2 443143.GM18_0422 3.76e-209 637.0 COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity recC - 3.1.11.5 ko:K03583 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_V_gamma k59_168869_1 1298598.JCM21714_1051 9.91e-17 86.7 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,4H9S3@91061|Bacilli,47049@74385|Gracilibacillus 91061|Bacilli G Mannitol dehydrogenase C-terminal domain mtlD - 1.1.1.17 ko:K00009 ko00051,map00051 - R02703 RC00085 ko00000,ko00001,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_168869_2 1121472.AQWN01000004_gene849 2.24e-28 127.0 COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24BSX@186801|Clostridia,264DF@186807|Peptococcaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_168869_3 1394178.AWOO02000007_gene3112 1.39e-41 151.0 COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,4EN1S@85012|Streptosporangiales 201174|Actinobacteria HJ RimK-like ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_168869_5 1394178.AWOO02000007_gene3112 3.31e-29 119.0 COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,4EN1S@85012|Streptosporangiales 201174|Actinobacteria HJ RimK-like ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_168869_6 211165.AJLN01000033_gene2690 1.55e-94 297.0 COG0477@1|root,COG2814@2|Bacteria,1GCP6@1117|Cyanobacteria 1117|Cyanobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_194767_1 1033802.SSPSH_000272 8.21e-19 85.1 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_194767_2 243233.MCA1739 8.09e-161 458.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,1XDRX@135618|Methylococcales 135618|Methylococcales G Belongs to the HpcH HpaI aldolase family - - 4.1.3.24,4.1.3.25,4.1.3.34 ko:K01644,ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_65150_1 1232437.KL662077_gene1919 5.7e-97 295.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,2MJ4R@213118|Desulfobacterales 28221|Deltaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_97614_1 351348.Maqu_2768 2.67e-140 411.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,464MZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_104052_1 765911.Thivi_1958 1.23e-77 244.0 COG3395@1|root,COG3395@2|Bacteria,1QKU1@1224|Proteobacteria,1TIZB@1236|Gammaproteobacteria,1WXF7@135613|Chromatiales 135613|Chromatiales S Type III effector Hrp-dependent - - - - - - - - - - - - DUF1357_C,DUF1537 k59_26353_1 56780.SYN_00567 1.31e-45 159.0 COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_136533_1 1391646.AVSU01000058_gene1010 9.14e-54 186.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,25QPV@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_136533_2 335543.Sfum_1586 1.07e-53 179.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2MQBX@213462|Syntrophobacterales 28221|Deltaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_84858_3 765913.ThidrDRAFT_3506 7.01e-47 154.0 COG2010@1|root,COG2010@2|Bacteria,1NDHN@1224|Proteobacteria,1S700@1236|Gammaproteobacteria,1WYGG@135613|Chromatiales 135613|Chromatiales C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1 k59_84858_4 1131553.JIBI01000006_gene1123 6.94e-23 92.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,373F7@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM Cytochrome c, class I - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_188578_1 1366050.N234_36180 6.23e-164 469.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae 28216|Betaproteobacteria L Elements of external origin - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32 k59_169123_1 1223521.BBJX01000010_gene183 7.58e-82 251.0 28H75@1|root,2Z7JG@2|Bacteria,1MU3Y@1224|Proteobacteria,2VNKC@28216|Betaproteobacteria,4ABKP@80864|Comamonadaceae 28216|Betaproteobacteria S Phage major capsid protein E - - - - - - - - - - - - Phage_cap_E k59_169123_2 795666.MW7_0990 2.79e-31 112.0 2D3KU@1|root,32R6F@2|Bacteria,1MZ1Z@1224|Proteobacteria,2VTVC@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_20053_1 335543.Sfum_0207 2.03e-123 372.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MR8Q@213462|Syntrophobacterales 28221|Deltaproteobacteria C NADH-Ubiquinone oxidoreductase (complex I), chain 5 nuoL-2 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_130318_1 933262.AXAM01000025_gene3425 9.52e-74 239.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2MHWP@213118|Desulfobacterales 28221|Deltaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_45933_1 243090.RB661 8.76e-58 189.0 2CCV8@1|root,2Z7KX@2|Bacteria 2|Bacteria S EcsC protein family lasA - - - - - - - - - - - EcsC k59_91323_1 1405.DJ92_5264 5.62e-13 77.4 COG3591@1|root,COG3591@2|Bacteria,1VEDS@1239|Firmicutes,4HVX6@91061|Bacilli 91061|Bacilli E Belongs to the peptidase S1B family - - - - - - - - - - - - - k59_91323_3 911045.PSE_0624 9.96e-62 203.0 COG1502@1|root,COG1502@2|Bacteria,1N9CD@1224|Proteobacteria 1224|Proteobacteria I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_91323_4 1123255.JHYS01000003_gene2817 1.03e-40 142.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,4ADQQ@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_613_1 1232410.KI421422_gene2003 2.45e-31 119.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,43UVU@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM OmpA MotB domain protein pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_613_2 517417.Cpar_0640 5.74e-24 111.0 COG0823@1|root,COG0823@2|Bacteria,1FEIQ@1090|Chlorobi 1090|Chlorobi U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_26578_1 96561.Dole_2054 7.6e-54 181.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WJV1@28221|Deltaproteobacteria,2MIHF@213118|Desulfobacterales 28221|Deltaproteobacteria S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_20060_1 572477.Alvin_1982 1.08e-130 414.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_13527_1 509191.AEDB02000081_gene2495 2.73e-42 154.0 COG3547@1|root,COG3547@2|Bacteria,1TRSB@1239|Firmicutes,249AC@186801|Clostridia,3WIGU@541000|Ruminococcaceae 186801|Clostridia L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_32986_1 1049564.TevJSym_br00100 4.59e-55 186.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - - k59_84894_1 626522.GCWU000325_00106 3.07e-16 79.0 COG2820@1|root,COG2820@2|Bacteria,4NESQ@976|Bacteroidetes,2FP2V@200643|Bacteroidia,1WD5M@1283313|Alloprevotella 976|Bacteroidetes F Phosphorylase superfamily amn - 3.2.2.4 ko:K01241 ko00230,map00230 - R00182 RC00063,RC00318 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_123790_1 1121861.KB899931_gene163 9.25e-78 241.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2JQH4@204441|Rhodospirillales 204441|Rhodospirillales S Protein conserved in bacteria - - - - - - - - - - - - Metallophos,Metallophos_2 k59_123790_2 1150626.PHAMO_400004 5.91e-93 283.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2JPMU@204441|Rhodospirillales 204441|Rhodospirillales M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_169136_1 472759.Nhal_0808 1.98e-33 118.0 COG4691@1|root,COG4691@2|Bacteria,1N09T@1224|Proteobacteria,1SH18@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Plasmid stability protein - - - ko:K21495 - - - - ko00000,ko02048 - - - Arc k59_169136_2 472759.Nhal_0807 2.23e-60 189.0 COG4113@1|root,COG4113@2|Bacteria,1RIR6@1224|Proteobacteria,1SG9Z@1236|Gammaproteobacteria,1WZQV@135613|Chromatiales 135613|Chromatiales S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_39456_1 543913.D521_1380 4.37e-21 87.8 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,1KQQA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H MoaE protein moaE - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_39456_2 768671.ThimaDRAFT_3688 8.42e-24 92.8 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,1S8S1@1236|Gammaproteobacteria,1WZ9G@135613|Chromatiales 135613|Chromatiales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_39456_3 1049564.TevJSym_ao00100 2.84e-171 492.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0303 Molybdopterin biosynthesis enzyme moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_65439_2 95619.PM1_0227095 1.94e-18 83.6 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_130347_1 1123257.AUFV01000001_gene1885 2.01e-18 89.0 COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein acetylation - - - - - - - - - - - - - k59_130347_2 1049564.TevJSym_ad01270 2.01e-95 283.0 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1J63J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes nudF GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3126 NUDIX k59_130347_3 264462.Bd1631 3.91e-64 206.0 COG4912@1|root,COG4912@2|Bacteria,1QSBJ@1224|Proteobacteria,42QNI@68525|delta/epsilon subdivisions,2WN26@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation k59_130347_5 765913.ThidrDRAFT_3161 1.26e-84 259.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_33011_1 868864.Dester_1517 1.71e-51 177.0 COG0165@1|root,COG0165@2|Bacteria,2G3PT@200783|Aquificae 200783|Aquificae E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_7163_1 1047013.AQSP01000115_gene354 1.85e-104 310.0 COG0451@1|root,COG0451@2|Bacteria,2NP15@2323|unclassified Bacteria 2|Bacteria GM 3-beta hydroxysteroid dehydrogenase/isomerase family uxs - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_179929_1 1280681.AUJZ01000032_gene1793 6.12e-17 85.1 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,4BYZK@830|Butyrivibrio 186801|Clostridia L DNA polymerase family A - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_114861_1 1541065.JRFE01000034_gene6036 9.75e-17 87.4 COG2730@1|root,COG4305@1|root,COG2730@2|Bacteria,COG4305@2|Bacteria,1GI7Y@1117|Cyanobacteria,3VKW0@52604|Pleurocapsales 1117|Cyanobacteria G rare lipoprotein A - - - - - - - - - - - - CBM_2 k59_186841_1 1209989.TepiRe1_0710 9.28e-178 501.0 COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24BWG@186801|Clostridia 186801|Clostridia S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470,ko:K22232 ko00330,ko00562,map00330,map00562 - R01884,R11771 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_147435_1 768671.ThimaDRAFT_2275 2.18e-125 373.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1WXSP@135613|Chromatiales 135613|Chromatiales G alpha beta alpha domain I - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_44808_2 335543.Sfum_0827 0.000167 46.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFQ@28221|Deltaproteobacteria,2MRGA@213462|Syntrophobacterales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_4153_1 631362.Thi970DRAFT_03965 9.73e-66 202.0 2D4HK@1|root,32TH5@2|Bacteria,1N3UQ@1224|Proteobacteria,1SBUJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_4153_2 631362.Thi970DRAFT_03964 7.26e-90 268.0 COG1396@1|root,COG1396@2|Bacteria,1N3RQ@1224|Proteobacteria,1S3WE@1236|Gammaproteobacteria,1X115@135613|Chromatiales 135613|Chromatiales K Antitoxin component of bacterial toxin-antitoxin system, MqsA - - - - - - - - - - - - MqsA_antitoxin k59_4153_3 631362.Thi970DRAFT_03963 2.78e-84 252.0 2DHBG@1|root,2ZZ37@2|Bacteria,1RGFW@1224|Proteobacteria,1S5S9@1236|Gammaproteobacteria,1WZU3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_4153_4 266117.Rxyl_1791 3.23e-72 241.0 COG1743@1|root,COG1743@2|Bacteria 2|Bacteria L DNA methylAse - - - - - - - - - - - - DUF1156,N6_N4_Mtase k59_24492_1 316273.XCV1748 2.06e-19 87.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1X3J8@135614|Xanthomonadales 135614|Xanthomonadales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_24492_3 522306.CAP2UW1_3421 2.32e-60 194.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VSDI@28216|Betaproteobacteria 28216|Betaproteobacteria S protein SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_205505_1 685727.REQ_33380 3.29e-56 191.0 COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4FYUZ@85025|Nocardiaceae 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_108708_1 1265313.HRUBRA_01216 1.52e-49 169.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1J5A0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_147436_1 335543.Sfum_4055 9.11e-160 453.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MQ6C@213462|Syntrophobacterales 28221|Deltaproteobacteria E ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_63395_1 933262.AXAM01000051_gene2985 2.98e-68 211.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MJQ6@213118|Desulfobacterales 28221|Deltaproteobacteria EH TIGRFAM glutamine amidotransferase of anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2496 GATase k59_63395_2 96561.Dole_1567 1.89e-60 196.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria,2MIMY@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2495 GATase,Glycos_trans_3N,Glycos_transf_3 k59_50202_1 768671.ThimaDRAFT_0339 3.61e-168 484.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1WXGE@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome bd ubiquinol oxidase, subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_4155_1 1177179.A11A3_14100 1.5e-20 85.9 2E7X7@1|root,332BS@2|Bacteria,1NG4S@1224|Proteobacteria,1SP9U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized KleE stable inheritance protein - - - - - - - - - - - - KleE k59_24495_1 269799.Gmet_0354 1.3e-39 151.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,43TJB@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM glycosyl transferase family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_30642_1 349124.Hhal_2086 4.68e-31 119.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_186852_1 1049564.TevJSym_ai00520 3.25e-95 298.0 COG2199@1|root,COG4223@1|root,COG2199@2|Bacteria,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_75669_2 99598.Cal7507_3723 2.45e-75 235.0 2AAD4@1|root,30ZP1@2|Bacteria,1GAXN@1117|Cyanobacteria 1117|Cyanobacteria S PFAM T4 bacteriophage base plate protein - - - - - - - - - - - - T4_baseplate k59_4157_2 316067.Geob_0454 1.17e-35 129.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria,43T9A@69541|Desulfuromonadales 28221|Deltaproteobacteria D PFAM Cobyrinic acid a,c-diamide synthase soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_88996_2 1056820.KB900643_gene824 7.72e-13 80.1 COG2885@1|root,COG4547@1|root,COG5384@1|root,COG2885@2|Bacteria,COG4547@2|Bacteria,COG5384@2|Bacteria,1MX1F@1224|Proteobacteria,1RYU1@1236|Gammaproteobacteria,2PNMF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria HJM Cadherin repeats. - - - - - - - - - - - - Cadherin_3,DUF4347,OmpA k59_30643_2 1195246.AGRI_05387 6.98e-67 212.0 COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,467MF@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_19,TPR_2,TPR_8 k59_30643_3 402626.Rpic_4863 5.3e-20 87.8 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,1K11E@119060|Burkholderiaceae 28216|Betaproteobacteria K response regulator - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_153705_1 375286.mma_1013 2.14e-127 379.0 COG0641@1|root,COG0641@2|Bacteria,1NG2E@1224|Proteobacteria,2VMIE@28216|Betaproteobacteria 28216|Betaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_153705_2 375286.mma_1014 1.07e-118 356.0 COG0535@1|root,COG0535@2|Bacteria,1ND1B@1224|Proteobacteria,2VJRZ@28216|Betaproteobacteria 28216|Betaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_153705_3 314231.FP2506_02849 0.000121 50.1 COG3409@1|root,COG3409@2|Bacteria,1PF27@1224|Proteobacteria,2VCUD@28211|Alphaproteobacteria,2PK63@255475|Aurantimonadaceae 28211|Alphaproteobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_153705_4 5145.XP_001903703.1 3.22e-07 62.8 COG0666@1|root,KOG4177@2759|Eukaryota,3A67M@33154|Opisthokonta,3P67D@4751|Fungi,3QSH4@4890|Ascomycota,21862@147550|Sordariomycetes,3UBI3@5139|Sordariales 4751|Fungi M Ankyrin repeat - - - - - - - - - - - - Ank,Ank_2,Ank_4 k59_134586_1 335543.Sfum_2564 6.02e-90 278.0 COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MR7F@213462|Syntrophobacterales 28221|Deltaproteobacteria C CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD,FeS k59_134586_2 96561.Dole_3184 9.46e-10 58.5 COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit - - 2.3.1.169 ko:K14138 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R08433,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhC k59_147449_1 876044.IMCC3088_1349 8.35e-14 78.6 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J4N1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 comC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_44824_1 1485545.JQLW01000005_gene1194 1.27e-34 124.0 COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria 1224|Proteobacteria I PFAM phosphoesterase, PA-phosphatase related - - - - - - - - - - - - PAP2 k59_44824_3 1535422.ND16A_2864 3.41e-43 151.0 COG1994@1|root,COG1994@2|Bacteria,1QX3I@1224|Proteobacteria,1T362@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase M50B-like - - - - - - - - - - - - Peptidase_M50B k59_44824_4 1122194.AUHU01000006_gene566 2.31e-29 114.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,464S7@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2873 O-acetylhomoserine sulfhydrylase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - iJN746.PP_2528 Cys_Met_Meta_PP k59_82739_1 933262.AXAM01000042_gene1833 4.25e-84 255.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MIB0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM AAA ATPase central domain protein - - - - - - - - - - - - AAA,AAA_5 k59_96426_2 1131553.JIBI01000018_gene516 1.65e-195 606.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_16,TonB_dep_Rec k59_192698_1 278963.ATWD01000001_gene2770 9.19e-22 99.8 COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia 204432|Acidobacteriia KU Transcriptional regulatory protein, C terminal - - - - - - - - - - - - PD40,Trans_reg_C k59_198685_1 384765.SIAM614_29521 2.74e-65 213.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2TSE4@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_75681_1 1469557.JSWF01000033_gene1645 5.99e-95 291.0 COG5361@1|root,COG5361@2|Bacteria,4NE76@976|Bacteroidetes,1I8E2@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_44827_1 439235.Dalk_1499 1.25e-27 117.0 COG0784@1|root,COG3290@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions 1224|Proteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_192699_1 1469245.JFBG01000052_gene2167 5.77e-71 221.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,1RMK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Branched-chain amino acid transport - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_140655_1 1225184.ALXE01000036_gene27 1.49e-34 130.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_129004_1 1121405.dsmv_3813 1.82e-94 287.0 COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,42MUB@68525|delta/epsilon subdivisions,2WIX2@28221|Deltaproteobacteria,2MJ4V@213118|Desulfobacterales 28221|Deltaproteobacteria P Major facilitator superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_30795_2 1049564.TevJSym_ab01800 9.38e-235 656.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1J58A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0826 Collagenase and related proteases yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_30795_4 1304877.KI519399_gene6325 1.61e-12 76.6 COG5653@1|root,COG5653@2|Bacteria,1N3Z9@1224|Proteobacteria,2TRT5@28211|Alphaproteobacteria,3JUA5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_173041_1 572477.Alvin_1266 8.77e-109 322.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_56239_1 1049564.TevJSym_ac01400 2.27e-163 479.0 28N8G@1|root,2ZBCV@2|Bacteria,1NMB1@1224|Proteobacteria,1SMP0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_96649_1 1121423.JONT01000003_gene1062 3.82e-93 285.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae 186801|Clostridia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_50444_1 1121438.JNJA01000060_gene1624 5.44e-41 148.0 COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria 1224|Proteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_50444_2 1280953.HOC_19991 9.36e-20 89.7 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA replication protein - - - - - - - - - - - - IstB_IS21 k59_45072_1 1232410.KI421418_gene2422 8.41e-62 202.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_140943_2 1121939.L861_08755 8.18e-46 164.0 COG0457@1|root,COG0457@2|Bacteria,1PEMT@1224|Proteobacteria,1S5W3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 k59_140943_3 1231392.OCGS_1270 1.8e-35 132.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU type II secretion system protein - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_153895_1 706587.Desti_2572 4.31e-56 197.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria 28221|Deltaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_122569_1 1121405.dsmv_0317 8.41e-40 140.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_122569_2 290397.Adeh_0141 5.55e-53 179.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2YU4K@29|Myxococcales 28221|Deltaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_198941_1 396588.Tgr7_3083 5.03e-167 473.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1SZ87@1236|Gammaproteobacteria,1X2J8@135613|Chromatiales 135613|Chromatiales P PFAM ABC transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_198941_2 396588.Tgr7_3082 1.16e-163 464.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQPA@1236|Gammaproteobacteria,1X2CQ@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_45081_2 1089553.Tph_c09570 3.76e-14 75.1 COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia,42G65@68295|Thermoanaerobacterales 186801|Clostridia S PFAM alpha beta hydrolase - - - ko:K06889,ko:K07397 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4,Peptidase_S9 k59_63697_1 754476.Q7A_2190 1.9e-57 197.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,462C5@72273|Thiotrichales 72273|Thiotrichales I PFAM AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_115105_1 157783.LK03_11265 3.2e-06 48.1 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_115105_2 550540.Fbal_2007 1.23e-55 179.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_187109_1 553385.JEMF01000073_gene1512 1.71e-08 57.8 COG1309@1|root,COG1309@2|Bacteria,1NDGU@1224|Proteobacteria,1SB19@1236|Gammaproteobacteria,1XRJB@135619|Oceanospirillales 135619|Oceanospirillales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_187109_2 1120983.KB894570_gene1759 0.000563 43.1 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_187110_1 1322246.BN4_10710 1.43e-74 236.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2M9PA@213115|Desulfovibrionales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_147723_2 1150399.AQYK01000002_gene3209 5.83e-40 167.0 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae 201174|Actinobacteria G Repeats in polycystic kidney disease 1 (PKD1) and other proteins wcoG - - - - - - - - - - - Laminin_G_3,PKD k59_153903_1 207559.Dde_0370 7.62e-06 54.7 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - AAA_16,GAF,HAMP,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg,dCache_1 k59_82921_1 572477.Alvin_0490 1.46e-59 197.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales 135613|Chromatiales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_180155_1 765911.Thivi_1406 2.01e-283 788.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1WX3J@135613|Chromatiales 135613|Chromatiales H Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_45091_1 1397528.Q671_14960 5.51e-70 221.0 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XS39@135619|Oceanospirillales 135619|Oceanospirillales L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_180490_1 876044.IMCC3088_246 3.3e-79 242.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain chvI GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K02483,ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_141368_3 857087.Metme_3427 7.01e-123 361.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1XE46@135618|Methylococcales 135618|Methylococcales L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_56551_2 76114.p2B5 1.94e-83 254.0 COG3701@1|root,COG3701@2|Bacteria,1MVUC@1224|Proteobacteria,2VP60@28216|Betaproteobacteria 28216|Betaproteobacteria U VirB8 protein - - - ko:K20531 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - VirB8 k59_193152_1 644282.Deba_1846 7.51e-05 43.1 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42W2F@68525|delta/epsilon subdivisions,2WRUM@28221|Deltaproteobacteria 28221|Deltaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control ihfA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_51248_1 1089553.Tph_c22910 9.07e-12 70.9 COG3385@1|root,COG3385@2|Bacteria,1UKR9@1239|Firmicutes,25G1P@186801|Clostridia 186801|Clostridia L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_187789_1 1121481.AUAS01000001_gene4575 2.36e-33 122.0 COG1309@1|root,COG1309@2|Bacteria,4NNK5@976|Bacteroidetes,47PWM@768503|Cytophagia 976|Bacteroidetes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_13,TetR_N k59_154652_1 1473546.CH76_07370 6.75e-39 144.0 COG2826@1|root,COG2826@2|Bacteria,1TRSF@1239|Firmicutes,4HCMP@91061|Bacilli 91061|Bacilli L Integrase - - - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_4936_1 1049564.TevJSym_aw00300 2.84e-131 386.0 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_135497_2 1089550.ATTH01000001_gene1830 2.42e-12 67.4 COG1595@1|root,COG1595@2|Bacteria,4NSN4@976|Bacteroidetes 976|Bacteroidetes K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF k59_148378_2 1134912.AJTV01000003_gene1567 1.47e-45 155.0 2D0K9@1|root,32T8S@2|Bacteria,1MZRW@1224|Proteobacteria,2UDZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_18158_2 232346.JHQL01000003_gene153 4.53e-08 62.4 2DR8G@1|root,32UQM@2|Bacteria,1R7WP@1224|Proteobacteria,1RZNG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_115782_1 1379281.AVAG01000029_gene37 3.89e-90 283.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2M7R9@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_173682_2 477184.KYC_16647 7.69e-20 87.8 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,3T2B4@506|Alcaligenaceae 28216|Betaproteobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_102532_3 883.DvMF_1461 0.000128 43.9 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2M91Y@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_173686_1 237368.SCABRO_00510 1.33e-25 96.7 2E8Z8@1|root,3338U@2|Bacteria 2|Bacteria S Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox k59_173686_2 323261.Noc_0090 3.45e-32 117.0 COG4113@1|root,COG4113@2|Bacteria,1N169@1224|Proteobacteria,1SIUZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PIN domain - - - - - - - - - - - - PIN k59_135504_1 90675.XP_010442455.1 8.68e-20 95.9 COG1219@1|root,KOG0745@2759|Eukaryota,37QEP@33090|Viridiplantae,3GX48@35493|Streptophyta,3HX6W@3699|Brassicales 35493|Streptophyta O C-terminal, D2-small domain, of ClpB protein - GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0031974,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small k59_199701_2 765913.ThidrDRAFT_0732 5.2e-70 214.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1WYAU@135613|Chromatiales 135613|Chromatiales O TIGRFAM Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin k59_102534_1 118168.MC7420_4491 8.08e-85 267.0 COG1403@1|root,COG1403@2|Bacteria,1G2XW@1117|Cyanobacteria,1H9JX@1150|Oscillatoriales 1117|Cyanobacteria L HNH endonuclease - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_154667_1 62928.azo1248 2.42e-70 219.0 COG1433@1|root,COG1433@2|Bacteria,1PW6J@1224|Proteobacteria,2VNDT@28216|Betaproteobacteria,2KYDE@206389|Rhodocyclales 206389|Rhodocyclales S Dinitrogenase iron-molybdenum cofactor, N-terminal - - - - - - - - - - - - DIMCO_N,Nitro_FeMo-Co k59_25489_1 861299.J421_2435 2.52e-25 110.0 COG0477@1|root,COG0477@2|Bacteria,1ZT3N@142182|Gemmatimonadetes 2|Bacteria U Sugar (and other) transporter emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_180791_3 1163407.UU7_15260 5.09e-149 438.0 COG4715@1|root,COG4715@2|Bacteria 2|Bacteria S zinc ion binding CP_1020 - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_180791_4 398578.Daci_4847 1.16e-60 216.0 COG5094@1|root,COG5094@2|Bacteria,1R4FU@1224|Proteobacteria,2VK12@28216|Betaproteobacteria,4AD41@80864|Comamonadaceae 28216|Betaproteobacteria K RNA polymerase II transcriptional preinitiation complex assembly - - - - - - - - - - - - - k59_180791_5 1163407.UU7_15270 5.4e-210 586.0 COG0714@1|root,COG0714@2|Bacteria,1QDUZ@1224|Proteobacteria,1RQGT@1236|Gammaproteobacteria,1X9N3@135614|Xanthomonadales 135614|Xanthomonadales S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_5 k59_180791_6 1163407.UU7_15275 0.0 919.0 COG1916@1|root,COG1916@2|Bacteria,1Q79N@1224|Proteobacteria,1RZ2Q@1236|Gammaproteobacteria,1X9MQ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_180791_7 1163407.UU7_15280 4.71e-212 594.0 COG2425@1|root,COG2425@2|Bacteria,1MW56@1224|Proteobacteria,1RQ93@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Von willebrand factor, type a - - - - - - - - - - - - VWA_CoxE k59_180791_9 1085623.GNIT_2958 1.23e-12 67.8 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,465XQ@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_31452_1 247634.GPB2148_2471 1.63e-35 145.0 COG2273@1|root,COG3488@1|root,COG2273@2|Bacteria,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,1RRXK@1236|Gammaproteobacteria,1J53U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C thiol oxidoreductase - - - - - - - - - - - - CBM_6,DHOR,F5_F8_type_C,Glyco_hydro_16,Lipoprotein_15,TSP_3 k59_71069_1 880072.Desac_1829 1.89e-93 283.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MQWC@213462|Syntrophobacterales 28221|Deltaproteobacteria C oxidoreductase, alpha subunit korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_76626_1 314278.NB231_03590 8.95e-09 59.7 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1WY2W@135613|Chromatiales 135613|Chromatiales L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_206338_1 251221.35214536 1.1e-10 68.6 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1G4UJ@1117|Cyanobacteria 1117|Cyanobacteria CO Disulphide bond corrector protein DsbC - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_109630_1 1121405.dsmv_3405 1.64e-82 258.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_180792_1 498211.CJA_0214 6.3e-281 807.0 COG5498@1|root,COG5498@2|Bacteria,1R4DU@1224|Proteobacteria,1RR8D@1236|Gammaproteobacteria,1FG6G@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolase family 81 - - - - - - - - - - - - CBM_6,DUF5011,Glyco_hydro_81 k59_135523_1 1047013.AQSP01000140_gene2447 8.83e-97 294.0 COG3328@1|root,COG3328@2|Bacteria,2NQXQ@2323|unclassified Bacteria 2|Bacteria L COGs COG3328 Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_115796_1 909943.HIMB100_00011830 5.39e-11 68.2 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,4BQ9C@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_25498_1 1121434.AULY01000014_gene2712 1.21e-34 136.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2M98X@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_56861_1 335543.Sfum_2964 5.06e-58 189.0 2F2II@1|root,33VFH@2|Bacteria,1N6CV@1224|Proteobacteria,42UDX@68525|delta/epsilon subdivisions,2WR4C@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_193488_2 1265505.ATUG01000003_gene574 9.37e-48 166.0 COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria,2MK9F@213118|Desulfobacterales 28221|Deltaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 k59_141668_1 1121405.dsmv_1308 7.18e-68 212.0 COG1309@1|root,COG1309@2|Bacteria,1R7QV@1224|Proteobacteria,43AFI@68525|delta/epsilon subdivisions,2WINE@28221|Deltaproteobacteria,2MJ31@213118|Desulfobacterales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_64282_1 1232437.KL662020_gene705 6.36e-103 313.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_38651_1 765912.Thimo_0742 1.51e-136 393.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales 135613|Chromatiales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_38651_2 1049564.TevJSym_am00090 1.16e-32 118.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1J5T9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_173693_1 247490.KSU1_C1634 7.93e-185 535.0 COG0021@1|root,COG0021@2|Bacteria,2IXIA@203682|Planctomycetes 203682|Planctomycetes G Belongs to the transketolase family - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_193495_1 930166.CD58_25350 1.27e-42 147.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_193495_3 522306.CAP2UW1_3923 3.96e-31 117.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KQ3X@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_38657_1 572477.Alvin_1034 6.73e-61 206.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1WVZE@135613|Chromatiales 135613|Chromatiales G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_38657_2 953739.SVEN_5076 1.04e-61 205.0 COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria 201174|Actinobacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase k59_109639_1 342113.DM82_1795 9.23e-29 114.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KDQ8@119060|Burkholderiaceae 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_109639_2 1452718.JBOY01000038_gene2015 9.61e-66 209.0 COG4757@1|root,COG4757@2|Bacteria,1Q1V6@1224|Proteobacteria,1RT3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_4950_1 114615.BRADO6329 2.41e-207 597.0 COG2355@1|root,COG3568@1|root,COG2355@2|Bacteria,COG3568@2|Bacteria,1R8HG@1224|Proteobacteria,2UNI6@28211|Alphaproteobacteria,3K34W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Ricin-type beta-trefoil - - - - - - - - - - - - Jacalin,Ricin_B_lectin k59_206358_1 706587.Desti_5205 2.54e-89 285.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MQBA@213462|Syntrophobacterales 28221|Deltaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_25510_1 1049564.TevJSym_ax00430 9.34e-203 577.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1J5MS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_31480_2 631362.Thi970DRAFT_01410 1.83e-47 162.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1WXGQ@135613|Chromatiales 135613|Chromatiales S High frequency lysogenization protein HflD homolog hflD - - ko:K07153 - - - - ko00000 - - - DUF489 k59_25743_1 933262.AXAM01000030_gene825 1.73e-113 340.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,2MJ4J@213118|Desulfobacterales 28221|Deltaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - FHA,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3 k59_64727_2 382464.ABSI01000017_gene91 1.52e-09 59.3 COG4974@1|root,COG4974@2|Bacteria,46SKH@74201|Verrucomicrobia,2IUAT@203494|Verrucomicrobiae 2|Bacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_102908_2 713586.KB900536_gene2658 2.05e-132 389.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_102908_3 1049564.TevJSym_ax00390 4.77e-71 216.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1JBZG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_18683_1 383407.XOC_3449 4.29e-125 430.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,1X7UP@135614|Xanthomonadales 135614|Xanthomonadales M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat k59_148711_1 1049564.TevJSym_au00120 1.8e-134 390.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1J4KY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - iPC815.YPO2896,iYL1228.KPN_02862 Aminotran_5 k59_25749_1 111781.Lepto7376_4405 2.11e-28 118.0 COG0527@1|root,COG0527@2|Bacteria,1G095@1117|Cyanobacteria,1H9UH@1150|Oscillatoriales 1117|Cyanobacteria E aspartate kinase, monofunctional class lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iJN678.lysC AA_kinase,ACT,ACT_7 k59_109967_1 765911.Thivi_2263 4.09e-20 89.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_109967_2 635013.TherJR_0997 1.44e-70 245.0 COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_8,PAS_9 k59_25751_1 391615.ABSJ01000035_gene980 2.12e-64 203.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1J4E4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D cell division ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_25751_2 28258.KP05_15125 1.36e-11 64.7 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XIAH@135619|Oceanospirillales 135619|Oceanospirillales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_45337_2 1198232.CYCME_1173 4.47e-42 142.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,460WA@72273|Thiotrichales 72273|Thiotrichales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_129187_1 933262.AXAM01000023_gene654 5.08e-46 154.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2MJMY@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_154093_1 710685.MycrhN_3115 9.17e-07 56.2 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2GKEU@201174|Actinobacteria,2342I@1762|Mycobacteriaceae 201174|Actinobacteria V ABC transporter - - - ko:K01990,ko:K21397 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC_tran,FHA k59_89383_1 228410.NE0901 1.59e-87 288.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2WEJA@28216|Betaproteobacteria,374P7@32003|Nitrosomonadales 28216|Betaproteobacteria EO pdz dhr glgf - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_45340_1 335543.Sfum_3207 2.66e-48 165.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42PRS@68525|delta/epsilon subdivisions,2WK0H@28221|Deltaproteobacteria 28221|Deltaproteobacteria EH PFAM aminotransferase, class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_154094_1 880072.Desac_0836 7.53e-68 230.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_83064_1 1307759.JOMJ01000004_gene2450 8.08e-74 232.0 2DC6N@1|root,2ZD32@2|Bacteria,1Q0S4@1224|Proteobacteria,436UF@68525|delta/epsilon subdivisions,2X1IB@28221|Deltaproteobacteria,2MF4A@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_160955_2 1134474.O59_000001 6.22e-20 89.7 2EGAG@1|root,33A2B@2|Bacteria,1NHMK@1224|Proteobacteria,1SIY7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_160955_6 443143.GM18_0512 1.05e-278 781.0 COG1196@1|root,COG3593@1|root,COG1196@2|Bacteria,COG3593@2|Bacteria,1R5X9@1224|Proteobacteria,42WCV@68525|delta/epsilon subdivisions,2WSNK@28221|Deltaproteobacteria 28221|Deltaproteobacteria L AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_167111_1 123214.PERMA_0817 3.97e-11 69.3 COG3156@1|root,COG3156@2|Bacteria,2G4SA@200783|Aquificae 200783|Aquificae U Type II secretion system (T2SS), protein K - - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_70623_1 335543.Sfum_2527 1.35e-106 332.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MQ85@213462|Syntrophobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_4522_2 765913.ThidrDRAFT_0523 2e-117 345.0 COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,1S2ZV@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET ABC transporter substrate-binding protein moxJ - - - - - - - - - - - Ank_2,Ank_4,Ank_5,SBP_bac_3 k59_4522_3 595536.ADVE02000001_gene1888 1.4e-49 166.0 COG0607@1|root,COG0607@2|Bacteria,1MZG3@1224|Proteobacteria,2U1W0@28211|Alphaproteobacteria,37012@31993|Methylocystaceae 28211|Alphaproteobacteria P Rhodanese-like domain - - - - - - - - - - - - Rhodanese k59_193000_1 639283.Snov_0024 5.19e-27 115.0 COG3941@1|root,COG3941@2|Bacteria 2|Bacteria O tape measure - - - - - - - - - - - - TMP_2,Tape_meas_lam_C k59_96863_1 713586.KB900536_gene819 5.52e-125 371.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0027 rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_96863_2 478741.JAFS01000002_gene788 9.81e-55 176.0 COG1371@1|root,COG1371@2|Bacteria,46YT2@74201|Verrucomicrobia,37GUG@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_96863_3 1049564.TevJSym_ap00300 2.79e-48 158.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1J6XR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_199192_1 237368.SCABRO_02137 1.58e-40 149.0 COG0644@1|root,COG0644@2|Bacteria 2|Bacteria C geranylgeranyl reductase activity prnA - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_38048_1 686340.Metal_3490 5.48e-65 223.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XESV@135618|Methylococcales 135618|Methylococcales T Diguanylate cyclase - - - - - - - - - - - - CHASE8,EAL,GGDEF,PAS,PAS_3,Response_reg k59_129199_1 1323663.AROI01000006_gene2745 1.38e-19 89.7 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_89395_1 317013.NY99_09410 7.47e-174 495.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1S1RT@1236|Gammaproteobacteria,1XC8F@135614|Xanthomonadales 135614|Xanthomonadales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_89395_3 443143.GM18_0518 1.58e-113 337.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,42TVH@68525|delta/epsilon subdivisions,2WR7Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_173187_1 933262.AXAM01000029_gene2727 3.91e-65 219.0 COG0699@1|root,COG0699@2|Bacteria,1R3WJ@1224|Proteobacteria,42N0G@68525|delta/epsilon subdivisions,2WKFJ@28221|Deltaproteobacteria,2MJ5I@213118|Desulfobacterales 28221|Deltaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_180305_3 883126.HMPREF9710_00358 0.0 1146.0 COG0210@1|root,COG1112@1|root,COG0210@2|Bacteria,COG1112@2|Bacteria,1N8SW@1224|Proteobacteria,2VZZ0@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain - - - - - - - - - - - - AAA_12 k59_83073_1 75379.Tint_3088 4.83e-82 259.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,1KJ6D@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase hoxJ - 2.7.13.3 ko:K10125,ko:K19661 ko02020,map02020 M00504,M00772 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,cNMP_binding k59_102389_1 639030.JHVA01000001_gene37 8.57e-15 82.0 COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria,2JI1W@204432|Acidobacteriia 204432|Acidobacteriia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_4775_1 28229.ND2E_0716 7.44e-07 52.4 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,2Q7SH@267889|Colwelliaceae 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_17908_1 1121918.ARWE01000001_gene3559 1.57e-72 242.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1,sCache_2 k59_161242_1 1121033.AUCF01000039_gene420 4.47e-152 442.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2JR1Q@204441|Rhodospirillales 204441|Rhodospirillales G PQQ-like domain - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_25248_1 105559.Nwat_2185 1.89e-67 214.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales 135613|Chromatiales M Belongs to the NAD(P)-dependent epimerase dehydratase family - - 5.1.3.2,5.1.3.5 ko:K01784,ko:K12448 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R01473,R02984 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_187586_2 1380391.JIAS01000013_gene3782 3.49e-183 577.0 COG3755@1|root,COG3755@2|Bacteria,1R2G9@1224|Proteobacteria,2TZJP@28211|Alphaproteobacteria,2JZ28@204441|Rhodospirillales 204441|Rhodospirillales S Lysozyme inhibitor LprI - - - - - - - - - - - - LprI k59_70852_1 1198232.CYCME_0347 7.38e-59 204.0 COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,462AH@72273|Thiotrichales 72273|Thiotrichales F Adenylate cyclase, class-I - - 4.6.1.1 ko:K05851 ko00230,ko02026,ko05111,map00230,map02026,map05111 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - - Adenyl_cycl_N,Adenylate_cycl k59_83322_1 1121007.AUML01000034_gene1755 7.54e-27 113.0 COG1305@1|root,COG1305@2|Bacteria,4NZRT@976|Bacteroidetes,1I8DQ@117743|Flavobacteriia,2YGTM@290174|Aquimarina 976|Bacteroidetes E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_core k59_31309_1 1283300.ATXB01000001_gene1728 5.76e-63 193.0 arCOG05205@1|root,32ZUE@2|Bacteria,1REG3@1224|Proteobacteria,1SRG3@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_89655_3 1286631.X805_16120 2.59e-17 77.4 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,1KM98@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_89655_4 335659.S23_47240 5.07e-09 59.3 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2U13Y@28211|Alphaproteobacteria,3JVCN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_206165_1 880072.Desac_0499 1.88e-103 312.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_129508_1 1121405.dsmv_2225 1.49e-70 226.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria,2MNB1@213118|Desulfobacterales 28221|Deltaproteobacteria M peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_141462_1 867903.ThesuDRAFT_00562 3.83e-110 323.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,3WCDD@538999|Clostridiales incertae sedis 186801|Clostridia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_206169_1 1049564.TevJSym_bn00100 1.48e-17 78.2 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1J62V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the UPF0301 (AlgH) family yqgE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_206169_2 1049564.TevJSym_bn00110 1.51e-63 197.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1J6MD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_206169_3 1122201.AUAZ01000007_gene3723 1.44e-06 49.7 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,46DHY@72275|Alteromonadaceae 1236|Gammaproteobacteria F Phosphoribosyl transferase domain pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_135279_1 998674.ATTE01000001_gene871 2.01e-12 67.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,461U9@72273|Thiotrichales 72273|Thiotrichales C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4 k59_135279_2 1123400.KB904768_gene3406 1.3e-21 92.4 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,462Q6@72273|Thiotrichales 72273|Thiotrichales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_167405_1 335543.Sfum_3485 1.12e-76 241.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2MQBW@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2768 NTP_transferase k59_141465_1 1049564.TevJSym_be00030 5.86e-103 306.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1J5V7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Peptidase family U32 yhbV - - - - - - - - - - - Peptidase_U32 k59_141465_2 292415.Tbd_0439 2.25e-21 95.5 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria,1KSBZ@119069|Hydrogenophilales 119069|Hydrogenophilales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_123100_7 82654.Pse7367_2268 7.23e-60 191.0 COG1443@1|root,COG1443@2|Bacteria,1GDFS@1117|Cyanobacteria 1117|Cyanobacteria I NUDIX domain - - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_50980_1 909663.KI867149_gene3195 2.05e-78 241.0 COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,2MRUI@213462|Syntrophobacterales 28221|Deltaproteobacteria S Menaquinone biosynthesis mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_199527_1 83406.HDN1F_18050 1.96e-48 177.0 COG3451@1|root,COG3451@2|Bacteria,1MUEN@1224|Proteobacteria,1RPAY@1236|Gammaproteobacteria,1J9V0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U F pilus assembly Type-IV secretion system for plasmid transfer - - - - - - - - - - - - DUF87,TraC_F_IV k59_154470_1 1122135.KB893134_gene3780 2.76e-43 153.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_180637_1 675817.VDA_001527 3.5e-122 358.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1XVNR@135623|Vibrionales 135623|Vibrionales L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_187594_3 1005395.CSV86_09098 4.29e-26 105.0 2F6JN@1|root,33Z2J@2|Bacteria,1NZ1Q@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_173462_1 1121439.dsat_0637 6.06e-69 228.0 COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2WNKD@28221|Deltaproteobacteria,2MES5@213115|Desulfovibrionales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_173462_2 138119.DSY4133 3.58e-37 135.0 COG3381@1|root,COG3381@2|Bacteria,1VGZ7@1239|Firmicutes,24ZAG@186801|Clostridia,264CM@186807|Peptococcaceae 186801|Clostridia S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_89661_1 1049564.TevJSym_as00150 4.98e-60 206.0 COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acid phosphatase homologues lssY - - ko:K03975 - - - - ko00000 - - - LssY_C,PAP2,SNARE_assoc k59_38405_1 56780.SYN_00295 1.06e-54 194.0 COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Alpha amylase catalytic - - - - - - - - - - - - Alpha-amylase,GDE_C,GDE_N k59_148216_1 439235.Dalk_0857 3.94e-35 138.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_56672_1 177437.HRM2_22700 2.03e-38 146.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_89666_1 247490.KSU1_D0302 9.4e-95 294.0 COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes 203682|Planctomycetes E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_135288_1 290398.Csal_0236 2.15e-21 97.1 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,1RNIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Trehalose_PPase k59_157543_2 926559.JoomaDRAFT_1282 6.16e-40 137.0 COG5646@1|root,COG5646@2|Bacteria,4PGHP@976|Bacteroidetes,1I35M@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_157543_3 572480.Arnit_1643 5.54e-16 75.5 COG1247@1|root,COG1247@2|Bacteria,1R9WS@1224|Proteobacteria,42RZM@68525|delta/epsilon subdivisions,2YP9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_177117_1 1515746.HR45_18265 3.09e-86 265.0 COG3654@1|root,COG3654@2|Bacteria,1NMI4@1224|Proteobacteria 1224|Proteobacteria S Fic/DOC family - - - - - - - - - - - - Fic k59_27944_1 323261.Noc_0312 4.81e-88 276.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_47335_1 1249627.D779_3756 1.14e-73 229.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_47335_2 1049564.TevJSym_ad00120 2.8e-62 210.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_86264_1 177437.HRM2_25100 1.57e-28 109.0 COG0745@1|root,COG0745@2|Bacteria,1QWNF@1224|Proteobacteria,43BTF@68525|delta/epsilon subdivisions,2X747@28221|Deltaproteobacteria,2MPJS@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_80002_1 1049564.TevJSym_ba00090 2.1e-35 127.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1J6ZX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the skp family skp GO:0001530,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0019867,GO:0022417,GO:0022607,GO:0030288,GO:0030312,GO:0030313,GO:0031647,GO:0031975,GO:0032978,GO:0033036,GO:0034613,GO:0042597,GO:0042802,GO:0043163,GO:0043165,GO:0043170,GO:0044085,GO:0044091,GO:0044238,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0050821,GO:0051082,GO:0051179,GO:0051205,GO:0051234,GO:0051604,GO:0051641,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0097367,GO:1901564 - ko:K06142 - - - - ko00000 - - - OmpH k59_131900_1 521045.Kole_0200 7.85e-97 294.0 COG0004@1|root,COG0004@2|Bacteria,2GD3C@200918|Thermotogae 200918|Thermotogae P Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_8503_1 1218076.BAYB01000028_gene4703 3.23e-19 92.0 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,2VJK9@28216|Betaproteobacteria,1K00X@119060|Burkholderiaceae 28216|Betaproteobacteria O cytochrome c biogenesis protein resB - - ko:K07399 - - - - ko00000 - - - ResB k59_112237_1 179408.Osc7112_1054 5.69e-101 308.0 COG3335@1|root,COG3335@2|Bacteria,1GQVS@1117|Cyanobacteria,1HC3Z@1150|Oscillatoriales 2|Bacteria L Rhodopirellula transposase family protein - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_80003_1 395495.Lcho_0175 3.77e-10 60.1 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1KJNR@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_80003_2 864051.BurJ1DRAFT_2039 1.23e-104 320.0 COG2807@1|root,COG2807@2|Bacteria,1QU85@1224|Proteobacteria,2VNPC@28216|Betaproteobacteria 28216|Betaproteobacteria P Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_53727_1 1144325.PMI22_05448 1.69e-81 256.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_66662_2 105559.Nwat_2428 6.73e-46 152.0 2EIWF@1|root,33CMR@2|Bacteria,1NWKI@1224|Proteobacteria,1SP3I@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_164003_3 1415778.JQMM01000001_gene1432 8.37e-106 338.0 COG2199@1|root,COG3287@1|root,COG3287@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria,1JBUB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - FIST,FIST_C,GGDEF,PAS_9 k59_21635_1 243090.RB2558 3.17e-49 169.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_183848_1 1303692.SFUL_2032 1.87e-44 157.0 COG3211@1|root,COG3211@2|Bacteria,2GJKE@201174|Actinobacteria 201174|Actinobacteria G Bacterial protein of unknown function (DUF839) - - - - - - - - - - - - DUF839,PD40 k59_27955_1 234267.Acid_2554 3.32e-174 500.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_118948_1 768671.ThimaDRAFT_0998 1.48e-157 455.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_14595_1 335543.Sfum_1550 2.8e-187 559.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_105582_1 1144305.PMI02_05357 1.18e-94 294.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2K0RG@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_92988_1 525897.Dbac_2911 5.48e-12 68.9 COG0524@1|root,COG0524@2|Bacteria,1Q1GY@1224|Proteobacteria,42REZ@68525|delta/epsilon subdivisions,2WNHE@28221|Deltaproteobacteria,2MFYN@213115|Desulfovibrionales 28221|Deltaproteobacteria G pfkB family carbohydrate kinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_92988_2 1123517.JOMR01000001_gene1375 1.74e-17 82.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,4607W@72273|Thiotrichales 72273|Thiotrichales M sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_8514_1 937777.Deipe_1286 5.92e-34 132.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GAF_2,GGDEF,Response_reg k59_98975_1 1254432.SCE1572_44930 3.79e-21 97.1 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AQK@68525|delta/epsilon subdivisions,2X64H@28221|Deltaproteobacteria,2Z00K@29|Myxococcales 28221|Deltaproteobacteria T HAMP domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_202973_1 933262.AXAM01000053_gene2714 1.77e-87 270.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales 28221|Deltaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261 ATP-grasp_2,Ligase_CoA k59_60359_1 283699.D172_2090 4.1e-55 178.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS116 IS110 IS902 - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_125434_1 933262.AXAM01000019_gene1095 8.9e-32 130.0 COG2203@1|root,COG2204@1|root,COG3852@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity regM - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_190080_1 631362.Thi970DRAFT_02094 5.66e-124 372.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales 135613|Chromatiales L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_144853_1 1385935.N836_21430 4.57e-36 141.0 COG1020@1|root,COG1020@2|Bacteria,1GBN8@1117|Cyanobacteria,1HH6H@1150|Oscillatoriales 1117|Cyanobacteria Q Condensation domain - - - - - - - - - - - - ADH_zinc_N,AMP-binding,AMP-binding_C,Condensation,KR,Nitroreductase,PP-binding k59_66669_1 1232683.ADIMK_3075 4.18e-90 273.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,464R9@72275|Alteromonadaceae 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters nifU - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_66669_2 580332.Slit_0806 4.3e-17 79.3 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VNE4@28216|Betaproteobacteria,44WC3@713636|Nitrosomonadales 28216|Betaproteobacteria E Beta-eliminating lyase nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5,Rhodanese k59_170877_1 1163617.SCD_n02058 2.52e-22 99.4 COG2199@1|root,COG3159@1|root,COG3159@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WEJC@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - DUF484,GGDEF k59_41150_1 1121405.dsmv_1014 3.62e-53 181.0 COG1925@1|root,COG1925@2|Bacteria,1PW7I@1224|Proteobacteria,42N77@68525|delta/epsilon subdivisions,2WKSU@28221|Deltaproteobacteria,2MI26@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system - - - - - - - - - - - - - k59_98976_1 1049564.TevJSym_ab01950 9.55e-194 546.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_183862_1 1267535.KB906767_gene702 1.59e-69 229.0 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_92992_1 335543.Sfum_0390 6.51e-178 520.0 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cluster binding protein - - - - - - - - - - - - CCG,Fer4_7,Fer4_8,LUD_dom k59_73133_1 225849.swp_1305 1.08e-20 89.4 2EFFQ@1|root,3398F@2|Bacteria,1NC1R@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_118964_1 1049564.TevJSym_as00710 3.09e-83 258.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404 GlutR_N,GlutR_dimer,Shikimate_DH k59_1741_1 1240350.AMZE01000017_gene3859 2.98e-19 92.0 COG0695@1|root,COG0695@2|Bacteria,1MWE2@1224|Proteobacteria,1RRRQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Integrating conjugative element protein - - - - - - - - - - - - - k59_98978_1 1121405.dsmv_1522 4.51e-46 160.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,42QTW@68525|delta/epsilon subdivisions,2WMNU@28221|Deltaproteobacteria,2MJYF@213118|Desulfobacterales 28221|Deltaproteobacteria G Major Facilitator Superfamily - - - ko:K02445 - - - - ko00000,ko02000 2.A.1.4.3 - - MFS_1 k59_137861_1 96561.Dole_1762 1.01e-44 160.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,2MJN5@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_53742_1 485915.Dret_1058 7.97e-44 149.0 COG0607@1|root,COG0607@2|Bacteria,1RA3A@1224|Proteobacteria,42QNH@68525|delta/epsilon subdivisions,2WMPB@28221|Deltaproteobacteria,2MACC@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Rhodanese domain protein - - - - - - - - - - - - MauE,Rhodanese k59_190087_1 1255043.TVNIR_0454 9.29e-101 301.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1WX3Q@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_183865_1 335543.Sfum_0108 5.21e-127 383.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MSIT@213462|Syntrophobacterales 28221|Deltaproteobacteria IQ AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_157553_1 765913.ThidrDRAFT_2926 2.68e-177 509.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RQ9N@1236|Gammaproteobacteria,1WWY3@135613|Chromatiales 135613|Chromatiales C PFAM Nickel-dependent hydrogenase, large subunit - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_157553_2 1283284.AZUK01000001_gene1626 1.03e-208 585.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RREW@1236|Gammaproteobacteria,1Y5SN@135624|Aeromonadales 135624|Aeromonadales C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_157553_3 1283284.AZUK01000001_gene1627 2.35e-298 840.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,PAS_9 k59_144864_1 1042377.AFPJ01000036_gene1233 1.6e-46 166.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_66674_1 582744.Msip34_1173 1.89e-52 177.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,2KKF7@206350|Nitrosomonadales 206350|Nitrosomonadales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_86292_1 903818.KI912268_gene1776 3.01e-27 113.0 COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria 57723|Acidobacteria T Response regulator receiver - - - - - - - - - - - - HTH_8,Sigma54_activat k59_8531_1 479433.Caci_7528 0.000374 50.1 COG2815@1|root,COG2815@2|Bacteria,2ID52@201174|Actinobacteria 201174|Actinobacteria S TIR domain - - - - - - - - - - - - TIR_2 k59_27959_1 933262.AXAM01000043_gene1185 2.02e-159 458.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,42Q0W@68525|delta/epsilon subdivisions,2WKD6@28221|Deltaproteobacteria,2MJD0@213118|Desulfobacterales 28221|Deltaproteobacteria S HipA N-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_27959_2 290317.Cpha266_2265 1.3e-38 133.0 COG1396@1|root,COG1396@2|Bacteria,1FFMJ@1090|Chlorobi 1090|Chlorobi K Helix-turn-helix domain - - - - - - - - - - - - - k59_27959_4 314282.PCNPT3_01365 3.16e-109 340.0 COG0438@1|root,COG0500@1|root,COG0438@2|Bacteria,COG2226@2|Bacteria,1RCC7@1224|Proteobacteria,1S51S@1236|Gammaproteobacteria,2QHC3@267894|Psychromonadaceae 1236|Gammaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_98983_1 706587.Desti_3270 7.19e-68 232.0 COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_112480_2 90814.KL370891_gene1641 1.33e-106 321.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,462DI@72273|Thiotrichales 72273|Thiotrichales L Helix-turn-helix domain - - - - - - - - - - - - HTH_38,rve k59_164209_3 329726.AM1_3921 6.18e-20 88.6 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - DAO,MTS,Methyltransf_31 k59_60639_1 709797.CSIRO_4236 2.78e-110 349.0 COG0326@1|root,COG0326@2|Bacteria 2|Bacteria O unfolded protein binding - - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3 k59_28201_1 335543.Sfum_0194 2.43e-11 63.5 COG1296@1|root,COG1296@2|Bacteria,1P6U3@1224|Proteobacteria,42QVQ@68525|delta/epsilon subdivisions,2WMW1@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM AzlC family protein - - - - - - - - - - - - AzlC k59_28201_2 335543.Sfum_0195 1.18e-43 144.0 COG4392@1|root,COG4392@2|Bacteria,1NEQP@1224|Proteobacteria,42VHX@68525|delta/epsilon subdivisions,2WRER@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Branched-chain amino acid transport protein (AzlD) - - - - - - - - - - - - AzlD k59_8805_1 243233.MCA1965 2.78e-226 632.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1XE8B@135618|Methylococcales 135618|Methylococcales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_8805_2 765910.MARPU_01750 2.97e-80 243.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_21962_1 335543.Sfum_0605 1.92e-95 297.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MR7G@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_73339_1 1049564.TevJSym_av00080 0.000122 43.9 2DTN4@1|root,32UVJ@2|Bacteria,1N2A5@1224|Proteobacteria,1SX01@1236|Gammaproteobacteria,1JB3B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_86556_1 313606.M23134_06237 3.39e-11 68.2 COG0500@1|root,COG0500@2|Bacteria,4NFKM@976|Bacteroidetes,47M99@768503|Cytophagia 976|Bacteroidetes Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,Methyltransf_31,TehB k59_119247_1 207559.Dde_0602 4.2e-38 145.0 COG5000@1|root,COG5000@2|Bacteria,1QUN4@1224|Proteobacteria,43BMS@68525|delta/epsilon subdivisions,2X76D@28221|Deltaproteobacteria,2MGW9@213115|Desulfovibrionales 28221|Deltaproteobacteria T Multi-sensor signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,sCache_3_2 k59_159045_2 933262.AXAM01000109_gene2062 1.14e-15 77.4 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MJIJ@213118|Desulfobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_87653_1 667014.Thein_0694 7.29e-116 345.0 COG1186@1|root,COG1186@2|Bacteria,2GGX5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_29276_1 325777.GW15_0206710 2.23e-51 187.0 COG0210@1|root,COG1112@1|root,COG1502@1|root,COG0210@2|Bacteria,COG1112@2|Bacteria,COG1502@2|Bacteria,1N8SW@1224|Proteobacteria,1S05Y@1236|Gammaproteobacteria,1XC3W@135614|Xanthomonadales 135614|Xanthomonadales IL AAA domain - - - - - - - - - - - - AAA_11,AAA_12,PLDc_2 k59_107200_1 234267.Acid_2941 6.29e-59 193.0 2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria 2|Bacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_15848_1 1120963.KB894491_gene1005 1.07e-06 45.4 2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria,1SGZR@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_15848_2 1049564.TevJSym_bf00120 4.41e-198 555.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1J6TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_4539,iSBO_1134.SBO_4033,iSbBS512_1146.SbBS512_E4507 HTS k59_178683_2 1049564.TevJSym_aj00310 1.26e-190 540.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_204300_1 335543.Sfum_2496 4.96e-77 238.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,42MIS@68525|delta/epsilon subdivisions,2WMK7@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_74325_1 880072.Desac_0433 4.14e-45 153.0 COG0589@1|root,COG0589@2|Bacteria,1N6DC@1224|Proteobacteria,42UXA@68525|delta/epsilon subdivisions,2WQF5@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_74325_2 880072.Desac_0432 2.38e-96 288.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - SpoIIAA-like,Usp k59_68416_1 2340.JV46_17000 1.63e-93 295.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_68416_2 1049564.TevJSym_aq00590 1.05e-178 503.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1J4QG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_185325_1 631362.Thi970DRAFT_01953 1.36e-86 257.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_87660_1 177437.HRM2_11850 6.42e-38 142.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_6,Pyr_redox_2 k59_107208_1 237368.SCABRO_01637 1.87e-98 308.0 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_133357_1 1121413.JMKT01000012_gene672 1.92e-49 176.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2M8HN@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - GAF_2,HTH_8,Sigma54_activat k59_100355_1 1049564.TevJSym_bv00090 4.97e-26 110.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1J6SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M involved in outer membrane biogenesis asmA - - ko:K07289 - - - - ko00000 - - - AsmA k59_62027_4 1380394.JADL01000009_gene3307 2.65e-71 224.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2V9V7@28211|Alphaproteobacteria,2JYEY@204441|Rhodospirillales 204441|Rhodospirillales S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_62027_5 948106.AWZT01000018_gene4708 6.61e-127 367.0 COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2VPP0@28216|Betaproteobacteria,1K047@119060|Burkholderiaceae 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF899) - - - - - - - - - - - - DUF899 k59_62027_6 1380394.JADL01000009_gene3303 1.36e-179 513.0 COG0745@1|root,COG0745@2|Bacteria,1MX29@1224|Proteobacteria,2TV8G@28211|Alphaproteobacteria,2JPZF@204441|Rhodospirillales 204441|Rhodospirillales KT RESPONSE REGULATOR receiver - - - - - - - - - - - - - k59_62027_7 443598.AUFA01000007_gene4549 9.33e-71 220.0 COG3391@1|root,COG3391@2|Bacteria,1N25Z@1224|Proteobacteria,2TUAK@28211|Alphaproteobacteria,3JUD4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S PQQ-like domain MA20_01585 - - - - - - - - - - - Glu_cyclase_2,PQQ_2 k59_204307_1 1049564.TevJSym_ak00150 1.84e-178 528.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_107212_1 1122621.ATZA01000059_gene4159 1.69e-70 226.0 COG5433@1|root,COG5433@2|Bacteria,4NHJC@976|Bacteroidetes,1IPH8@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_107213_2 998674.ATTE01000001_gene3699 7.58e-13 67.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,45ZNU@72273|Thiotrichales 72273|Thiotrichales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_139270_1 335543.Sfum_3466 2.06e-72 235.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2MR5A@213462|Syntrophobacterales 28221|Deltaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_159067_1 1121405.dsmv_3583 2.96e-117 338.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,2MIQ4@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_3005_1 572477.Alvin_1067 1.25e-69 231.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQIN@1236|Gammaproteobacteria,1WXV5@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,HATPase_c,HisKA,PAS_3,dCache_1 k59_55002_1 1121405.dsmv_3570 3.61e-129 378.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_100361_1 96561.Dole_2209 1.11e-46 154.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2MJUT@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_23027_1 485916.Dtox_2239 1.99e-83 257.0 28J8Y@1|root,2Z943@2|Bacteria,1UKQN@1239|Firmicutes,25G19@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_23027_2 522306.CAP2UW1_0186 3.23e-70 236.0 COG3464@1|root,COG3464@2|Bacteria 2|Bacteria - - - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_ISL3,zf-IS66 k59_43079_1 1499967.BAYZ01000080_gene893 4.61e-14 67.8 COG2944@1|root,COG2944@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K18830 - - - - ko00000,ko02048,ko03000 - - - HTH_3,TIR_2 k59_43079_2 279238.Saro_3306 1.67e-12 67.8 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2K0DQ@204457|Sphingomonadales 204457|Sphingomonadales S 2-nitropropane dioxygenase - - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO,ThiG k59_87676_1 1265313.HRUBRA_00889 2.13e-162 457.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_204311_1 639283.Snov_1749 4.61e-65 220.0 COG0277@1|root,COG0277@2|Bacteria,1QA8V@1224|Proteobacteria,2V8HI@28211|Alphaproteobacteria,3F20M@335928|Xanthobacteraceae 28211|Alphaproteobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_197498_1 1005395.CSV86_09652 3.97e-06 54.7 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YVSH@136845|Pseudomonas putida group 1236|Gammaproteobacteria T Signal transduction histidine kinase chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_152471_1 1499967.BAYZ01000028_gene1305 2.8e-94 285.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_48884_1 768671.ThimaDRAFT_3868 5.47e-47 154.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1WX8R@135613|Chromatiales 135613|Chromatiales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_87680_1 335543.Sfum_0828 8.28e-47 168.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2MR2G@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_185355_1 768671.ThimaDRAFT_3098 3.04e-80 251.0 COG1653@1|root,COG1653@2|Bacteria,1R5DC@1224|Proteobacteria,1S3CM@1236|Gammaproteobacteria,1X05G@135613|Chromatiales 135613|Chromatiales G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 k59_55006_2 557598.LHK_02912 2.86e-46 159.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,2KQB3@206351|Neisseriales 206351|Neisseriales C electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_3011_1 1454004.AW11_03836 7.5e-25 100.0 COG0741@1|root,COG0741@2|Bacteria,1N8BR@1224|Proteobacteria,2VMIJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Lytic transglycosylase catalytic trbN - - - - - - - - - - - SLT k59_3011_2 105559.Nwat_2446 1.87e-32 117.0 COG1961@1|root,COG1961@2|Bacteria,1R482@1224|Proteobacteria,1S2PK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_36069_1 1121405.dsmv_1658 1.45e-30 110.0 28T1G@1|root,2ZFAR@2|Bacteria,1P9FQ@1224|Proteobacteria,432CF@68525|delta/epsilon subdivisions,2WYI4@28221|Deltaproteobacteria,2MPCD@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_178704_2 713586.KB900536_gene883 4.3e-21 101.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 k59_107216_1 1123367.C666_10950 7.51e-76 232.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,2KW7A@206389|Rhodocyclales 206389|Rhodocyclales F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_107216_2 3988.XP_002536756.1 4.02e-40 147.0 2BGJX@1|root,2S19K@2759|Eukaryota,380MM@33090|Viridiplantae 33090|Viridiplantae O Redoxin - - - - - - - - - - - - Redoxin k59_107216_3 382464.ABSI01000012_gene2157 2.12e-11 60.1 2BFNH@1|root,329GX@2|Bacteria,46WJ5@74201|Verrucomicrobia 74201|Verrucomicrobia S Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_191674_2 1453501.JELR01000002_gene920 6.01e-89 268.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,467AP@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein, hemolysin III homolog yqfA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_120864_1 522373.Smlt1854 2.33e-78 254.0 COG4733@1|root,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,1RRUV@1236|Gammaproteobacteria,1X3BW@135614|Xanthomonadales 135614|Xanthomonadales S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_120864_2 1121935.AQXX01000096_gene2519 2.22e-64 197.0 28JTG@1|root,2Z9IR@2|Bacteria,1PCXZ@1224|Proteobacteria,1SIJB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_49078_1 1049564.TevJSym_ai00410 1.83e-246 717.0 COG4252@1|root,COG5002@1|root,COG4252@2|Bacteria,COG5002@2|Bacteria,1MUHS@1224|Proteobacteria,1RQR2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE2,HATPase_c,PAS_4,PAS_8 k59_172176_1 857087.Metme_3086 5.37e-34 119.0 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,1S9F8@1236|Gammaproteobacteria,1XGY5@135618|Methylococcales 135618|Methylococcales C Ferredoxin - - - - - - - - - - - - - k59_172176_2 768671.ThimaDRAFT_4661 1.59e-42 142.0 COG1146@1|root,COG1146@2|Bacteria,1QW5F@1224|Proteobacteria,1T4WS@1236|Gammaproteobacteria,1WYJJ@135613|Chromatiales 135613|Chromatiales C TIGRFAM ferredoxin III - - - - - - - - - - - - Fer4 k59_43407_1 290512.Paes_1268 9.68e-74 234.0 COG0079@1|root,COG0079@2|Bacteria,1FE4A@1090|Chlorobi 1090|Chlorobi E PFAM aminotransferase, class I and II - - 2.6.1.9,4.1.1.81 ko:K00817,ko:K04720 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243,R06530 RC00006,RC00517,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_43407_2 765913.ThidrDRAFT_2647 1.22e-23 100.0 COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,1RN84@1236|Gammaproteobacteria,1WXAF@135613|Chromatiales 135613|Chromatiales U Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_197698_1 1121405.dsmv_0205 3.61e-62 214.0 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales 28221|Deltaproteobacteria S metal-dependent phosphohydrolase 7TM intracellular region - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_29532_1 1453501.JELR01000001_gene3040 1.13e-58 193.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,46506@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_133528_1 243233.MCA0364 2.81e-17 80.1 COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales 135618|Methylococcales S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_133528_2 933262.AXAM01000106_gene2630 5.29e-135 400.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM Mammalian cell entry related domain protein pqiB - - ko:K06192 - - - - ko00000 - - - MlaD k59_165544_1 933262.AXAM01000002_gene543 5.89e-72 230.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TraB family protein - - - - - - - - - - - - TraB k59_139470_1 1232437.KL662031_gene2606 3.73e-25 96.3 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MKI6@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the UPF0109 family - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_139470_2 1232410.KI421413_gene925 1.71e-30 110.0 2CIAT@1|root,2ZCZZ@2|Bacteria,1P8SH@1224|Proteobacteria,432KT@68525|delta/epsilon subdivisions,2WYI7@28221|Deltaproteobacteria,43VNF@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_87875_1 1049564.TevJSym_ag00080 2.46e-273 750.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1J5A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_87875_2 1049564.TevJSym_ag00070 2.81e-139 397.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cytochrome C1 family petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_139471_2 880072.Desac_1842 2.49e-66 209.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2MQVR@213462|Syntrophobacterales 28221|Deltaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_178909_1 195253.Syn6312_2337 8.53e-104 315.0 COG4585@1|root,COG4585@2|Bacteria,1GC2D@1117|Cyanobacteria 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - DUF4325 k59_81683_1 1167006.UWK_02518 5.79e-64 200.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2MJC6@213118|Desulfobacterales 28221|Deltaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_81683_2 671143.DAMO_0070 3.34e-43 152.0 COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria 2|Bacteria L Phage integrase, N-terminal SAM-like domain xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_172181_1 1121272.KB903249_gene1451 3.77e-11 63.5 COG1309@1|root,COG1309@2|Bacteria,2GM45@201174|Actinobacteria,4DCTR@85008|Micromonosporales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_6,TetR_N k59_107464_1 565045.NOR51B_673 1.73e-57 179.0 COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria 1224|Proteobacteria L Plasmid maintenance system killer higB GO:0008150,GO:0008219,GO:0009987 - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_107464_2 565045.NOR51B_314 8.82e-50 159.0 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1S83W@1236|Gammaproteobacteria,1JBIM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_107464_3 323261.Noc_0673 4.68e-214 599.0 28IV0@1|root,2Z8TM@2|Bacteria,1QK38@1224|Proteobacteria,1S19C@1236|Gammaproteobacteria,1X0K3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_10302_1 1121405.dsmv_0969 3.22e-109 323.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales 28221|Deltaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_16082_1 289376.THEYE_A0758 7.72e-76 249.0 COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae 40117|Nitrospirae O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,Lon_C,Response_reg k59_62298_2 68219.JNXI01000017_gene7237 8.74e-41 150.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.28 ko:K00141 ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220 M00537,M00538 R01293,R01419,R05289,R05663,R05664,R07667 RC00075 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_68700_1 290317.Cpha266_2448 5.85e-52 171.0 COG2930@1|root,COG2930@2|Bacteria,1FDZ7@1090|Chlorobi 1090|Chlorobi S (twin-arginine translocation) pathway signal - - - - - - - - - - - - - k59_31631_2 631362.Thi970DRAFT_02472 4.78e-26 103.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_38791_1 933262.AXAM01000057_gene1546 4.75e-94 282.0 COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria,2MJIW@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_167972_1 1121405.dsmv_2856 2.94e-50 176.0 COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_136041_1 686578.AFFX01000005_gene4058 3.22e-39 148.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_200065_1 886293.Sinac_6831 5.06e-189 538.0 COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_57339_2 1116472.MGMO_15c00150 2.85e-163 468.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1XEPK@135618|Methylococcales 135618|Methylococcales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_32009_1 1286106.MPL1_04872 2.97e-139 402.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,46077@72273|Thiotrichales 72273|Thiotrichales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_32009_2 765913.ThidrDRAFT_3809 2.88e-100 295.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales 135613|Chromatiales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_51665_1 1123400.KB904750_gene690 8.64e-50 197.0 COG0823@1|root,COG2834@1|root,COG3386@1|root,COG0823@2|Bacteria,COG2834@2|Bacteria,COG3386@2|Bacteria,1QXUF@1224|Proteobacteria,1T5V1@1236|Gammaproteobacteria 1224|Proteobacteria GMU Cadherin domain - - - - - - - - - - - - Cadherin,DUF4214,DUF5122,HYR,VCBS k59_116167_1 1123261.AXDW01000009_gene151 5.88e-33 125.0 COG0500@1|root,COG2226@2|Bacteria,1NDW0@1224|Proteobacteria,1T5AQ@1236|Gammaproteobacteria,1X935@135614|Xanthomonadales 135614|Xanthomonadales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_12819_1 1453501.JELR01000002_gene1350 0.0 1671.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,465PA@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_12819_2 443906.CMM_1970 1.69e-37 131.0 COG3727@1|root,COG3727@2|Bacteria,2IKPY@201174|Actinobacteria,4FPXP@85023|Microbacteriaceae 201174|Actinobacteria L DNA mismatch endonuclease Vsr vsr - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - DUF559,NUDIX,Vsr k59_12819_3 1453501.JELR01000002_gene1348 3.25e-204 570.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Methyl-transferase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_12819_4 1333507.AUTQ01000152_gene4316 2.98e-31 110.0 COG3311@1|root,COG3311@2|Bacteria,1N779@1224|Proteobacteria,1SCHD@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG1910 Periplasmic molybdate-binding protein domain - - - - - - - - - - - - HTH_17 k59_136053_1 56107.Cylst_3721 3.2e-75 237.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1HJ2V@1161|Nostocales 1117|Cyanobacteria C PFAM Alanine dehydrogenase PNT, C-terminal domain pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_51671_1 1121422.AUMW01000013_gene1529 2.13e-44 160.0 COG0699@1|root,COG0699@2|Bacteria,1TR0Q@1239|Firmicutes,24BWJ@186801|Clostridia,261EP@186807|Peptococcaceae 186801|Clostridia S Dynamin family - - - - - - - - - - - - Dynamin_N k59_25828_1 1049564.TevJSym_aj00320 2.22e-151 440.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1J5GI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_25828_3 396588.Tgr7_0769 5.86e-129 380.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_90446_1 1111728.ATYS01000001_gene2273 7.25e-103 316.0 COG2425@1|root,COG2425@2|Bacteria,1R55U@1224|Proteobacteria,1RSPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K11089 ko05322,map05322 - - - ko00000,ko00001 - - - TROVE,VWA_CoxE k59_148788_1 857087.Metme_1124 0.0 1719.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_90449_1 304371.MCP_1037 3.45e-72 236.0 COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,2N96H@224756|Methanomicrobia 224756|Methanomicrobia J Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 infB - - ko:K03243 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2 k59_57363_1 1049564.TevJSym_ar00430 1.82e-95 307.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4MB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_12835_1 1125863.JAFN01000001_gene1160 2.54e-64 209.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_5470_1 383372.Rcas_4152 2.39e-12 66.2 COG0745@1|root,COG0745@2|Bacteria,2GBMP@200795|Chloroflexi,3782I@32061|Chloroflexia 32061|Chloroflexia T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_116192_2 933262.AXAM01000048_gene2590 9.17e-78 243.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales 28221|Deltaproteobacteria M SMART PDZ DHR GLGF domain protein rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_142149_1 1121405.dsmv_1268 2.25e-51 180.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MMIM@213118|Desulfobacterales 28221|Deltaproteobacteria G TIGRFAM alpha-glucan - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_77055_1 631362.Thi970DRAFT_03746 1.03e-61 204.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria 1224|Proteobacteria L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_102981_2 203122.Sde_3726 3.65e-311 860.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46C30@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Flavin containing amine oxidoreductase - - 1.3.99.23,5.2.1.13 ko:K09516,ko:K09835 ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110 M00097 R07163,R07512 RC01835,RC01960 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_102981_3 1463934.JOCF01000066_gene5451 3.35e-144 436.0 COG1233@1|root,COG1233@2|Bacteria,2GP0A@201174|Actinobacteria 201174|Actinobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_102981_4 203122.Sde_3725 0.0 3809.0 COG0300@1|root,COG1020@1|root,COG3321@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,465SE@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Non-ribosomal peptide synthetase - - - ko:K15395 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_102981_5 2340.JV46_16200 1.5e-29 117.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1J4PA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_200079_1 1399774.JDWH01000041_gene1720 5.45e-107 311.0 COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,1S08N@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Site-specific recombinases, DNA invertase Pin homologs - - - ko:K14060 - - - - ko00000 - - - HTH_7,Resolvase k59_161950_1 765912.Thimo_2201 1.04e-52 166.0 COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,1S9Q7@1236|Gammaproteobacteria,1WYV4@135613|Chromatiales 135613|Chromatiales S Txe YoeB family - - - ko:K19158 - - - - ko00000,ko01000,ko02048 - - - YoeB_toxin k59_161950_2 765912.Thimo_2202 1.61e-47 153.0 COG2161@1|root,COG2161@2|Bacteria,1N0JP@1224|Proteobacteria,1SA1E@1236|Gammaproteobacteria,1WZ4S@135613|Chromatiales 135613|Chromatiales D Antitoxin component of a toxin-antitoxin (TA) module - - - ko:K19159 - - - - ko00000,ko02048 - - - PhdYeFM_antitox k59_161950_4 1120925.F941_02225 2.57e-60 189.0 COG2050@1|root,COG2050@2|Bacteria,1RK46@1224|Proteobacteria,1S68C@1236|Gammaproteobacteria,3NJDA@468|Moraxellaceae 1236|Gammaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_110124_1 471852.Tcur_4584 3.13e-66 226.0 COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4EMM0@85012|Streptosporangiales 201174|Actinobacteria O HypF finger - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_181143_1 1121428.DESHY_160196___1 3.83e-56 190.0 COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,26027@186807|Peptococcaceae 186801|Clostridia H TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_161953_1 1265505.ATUG01000001_gene3293 8.71e-36 124.0 COG2044@1|root,COG2044@2|Bacteria,1RK3U@1224|Proteobacteria,42SYH@68525|delta/epsilon subdivisions,2WPGT@28221|Deltaproteobacteria,2MK3I@213118|Desulfobacterales 28221|Deltaproteobacteria S DsrE/DsrF-like family - - - ko:K06039 - - - - ko00000 - - - DrsE k59_161953_2 56780.SYN_00675 1.48e-50 162.0 COG3370@1|root,COG3370@2|Bacteria,1N3DX@1224|Proteobacteria,42UA2@68525|delta/epsilon subdivisions,2WQ2I@28221|Deltaproteobacteria 28221|Deltaproteobacteria O peroxiredoxin activity - - - - - - - - - - - - DrsE k59_116205_1 335543.Sfum_1723 1.44e-74 244.0 COG0070@1|root,COG0493@1|root,COG1145@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,2MR5X@213462|Syntrophobacterales 28221|Deltaproteobacteria C GXGXG motif - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF k59_5486_1 1125863.JAFN01000001_gene2314 9.78e-82 248.0 COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,42Q20@68525|delta/epsilon subdivisions,2WP8Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria M GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L k59_18789_1 314278.NB231_01274 5.52e-173 515.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_12859_2 765913.ThidrDRAFT_3178 3.7e-117 345.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_181145_1 768671.ThimaDRAFT_0807 1.76e-56 186.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1RQQB@1236|Gammaproteobacteria,1WYDA@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - - - - - - - - - - DUF1956,TetR_N k59_181145_2 768671.ThimaDRAFT_0806 6.61e-60 201.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,1WXVB@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_18790_1 1049564.TevJSym_ap00450 2.64e-190 553.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_77073_1 115417.EPrPW00000020998 7.44e-06 51.6 28KN3@1|root,2QT3M@2759|Eukaryota,1MG8S@121069|Pythiales 2759|Eukaryota S Transmembrane protein. Source PGD - - - - - - - - - - - - AA_permease_2 k59_155122_1 1121396.KB893100_gene4319 2.22e-68 234.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_90462_1 335543.Sfum_0362 4.44e-133 412.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WIYD@28221|Deltaproteobacteria,2MQ4W@213462|Syntrophobacterales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_174544_1 479433.Caci_3792 0.000102 47.0 COG5653@1|root,COG5653@2|Bacteria,2H2M1@201174|Actinobacteria 201174|Actinobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_174544_2 1502852.FG94_00491 3.18e-15 76.3 COG0438@1|root,COG0438@2|Bacteria,1MWVX@1224|Proteobacteria,2VN6U@28216|Betaproteobacteria,476MU@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyl transferases group 1 - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP k59_116636_1 1121405.dsmv_1665 1.44e-139 404.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2MMPY@213118|Desulfobacterales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_194428_1 1049564.TevJSym_aa00660 1.24e-145 419.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1J587@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the ribF family ribF GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0025,iJN746.PP_0602 FAD_syn,Flavokinase k59_103278_1 335543.Sfum_2401 1.98e-69 236.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1 k59_149004_1 177437.HRM2_44710 9.33e-73 234.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_168365_1 1173026.Glo7428_0792 8.52e-56 197.0 COG2217@1|root,COG2217@2|Bacteria,1G0JR@1117|Cyanobacteria 1117|Cyanobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC pacS GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_207009_1 857087.Metme_3216 6.31e-103 311.0 COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_168366_1 298653.Franean1_3164 4.15e-13 73.9 COG4467@1|root,COG4467@2|Bacteria,2IDK7@201174|Actinobacteria 201174|Actinobacteria S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,zf-IS66 k59_116650_1 270374.MELB17_01115 2.04e-96 294.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_149008_1 1411685.U062_01085 0.000214 43.5 2EPXK@1|root,33HI4@2|Bacteria,1NHK6@1224|Proteobacteria,1SH00@1236|Gammaproteobacteria,1JBBY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_5754_1 653733.Selin_1807 1.9e-57 197.0 COG1055@1|root,COG1055@2|Bacteria 2|Bacteria P arsenite transmembrane transporter activity CP_0904 - - - - - - - - - - - Na_H_antiport_3 k59_103295_1 642492.Clole_0588 2.13e-54 184.0 COG0583@1|root,COG0583@2|Bacteria,1TRYW@1239|Firmicutes,249AX@186801|Clostridia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_200369_1 469381.Dpep_1493 9.52e-24 101.0 COG0701@1|root,COG0701@2|Bacteria,3TAPB@508458|Synergistetes 508458|Synergistetes S Permease - - - - - - - - - - - - ArsP_1 k59_168384_1 1049564.TevJSym_ak00130 4.44e-119 353.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1J4H4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4669 UbiD k59_155482_2 342113.DM82_2998 6.16e-138 413.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2VKBE@28216|Betaproteobacteria 28216|Betaproteobacteria Q Flavin containing amine oxidoreductase crtI - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_155482_3 1480694.DC28_15245 1.78e-41 144.0 2ECZ8@1|root,336W9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_77569_1 192952.MM_1582 8.19e-25 97.4 COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia 224756|Methanomicrobia S PFAM NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_149019_1 1279009.ADICEAN_03679 0.000691 45.1 COG0640@1|root,COG0640@2|Bacteria,4NUW3@976|Bacteroidetes,47RXB@768503|Cytophagia 976|Bacteroidetes K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_174570_1 1121939.L861_20055 3.39e-56 187.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1XICQ@135619|Oceanospirillales 135619|Oceanospirillales P found to be peripherally associated with the inner membrane in Escherichia coli trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_174570_2 1049564.TevJSym_ag00980 6e-166 477.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1J4T7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iPC815.YPO3762,iSFV_1184.SFV_3651 TrkH k59_57758_1 399795.CtesDRAFT_PD4267 7.02e-17 79.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2VPEY@28216|Betaproteobacteria,4AA21@80864|Comamonadaceae 28216|Betaproteobacteria E Lysine exporter protein (Lyse ygga) leuE_1 - - - - - - - - - - - LysE k59_57758_2 1049564.TevJSym_an00090 1.35e-165 467.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,1RQ60@1236|Gammaproteobacteria,1J5AI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_103312_1 420247.Msm_1694 4.29e-14 79.0 COG1112@1|root,arCOG00803@2157|Archaea,2XUVX@28890|Euryarchaeota,23NQQ@183925|Methanobacteria 183925|Methanobacteria L Protein of unknown function (DUF4011) - - - - - - - - - - - - AAA_11,AAA_12,DUF3320,DUF4011 k59_103321_1 870187.Thini_1614 8.56e-62 207.0 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,1RQDM@1236|Gammaproteobacteria,4623T@72273|Thiotrichales 72273|Thiotrichales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_105927_2 765911.Thivi_2283 3.91e-257 736.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria,1WX5Q@135613|Chromatiales 135613|Chromatiales O associated with various cellular activities - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small k59_67047_1 1123401.JHYQ01000003_gene2126 1.91e-210 586.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,461QE@72273|Thiotrichales 72273|Thiotrichales S Alanine dehydrogenase/PNT, C-terminal domain - - - ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_67047_2 338963.Pcar_1091 8.41e-169 477.0 COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42PBT@68525|delta/epsilon subdivisions,2WMAY@28221|Deltaproteobacteria,43TIB@69541|Desulfuromonadales 28221|Deltaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_N,HTH_18 k59_67047_4 44251.PDUR_21255 3.96e-10 62.4 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli,26TK1@186822|Paenibacillaceae 91061|Bacilli L DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_22050_1 933262.AXAM01000016_gene149 1.57e-86 276.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_132264_1 472759.Nhal_3945 9.48e-55 175.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_125747_1 471852.Tcur_1164 6.13e-26 120.0 COG4995@1|root,COG4995@2|Bacteria,2I0C4@201174|Actinobacteria,4EQ7W@85012|Streptosporangiales 201174|Actinobacteria K CHAT domain - - - - - - - - - - - - CHAT k59_125747_5 290398.Csal_1325 2.73e-36 160.0 COG1196@1|root,COG1196@2|Bacteria,1R4S3@1224|Proteobacteria,1S05H@1236|Gammaproteobacteria,1XMX2@135619|Oceanospirillales 135619|Oceanospirillales D nuclear chromosome segregation - - - - - - - - - - - - - k59_125747_8 1111728.ATYS01000091_gene1311 1.09e-50 176.0 COG2378@1|root,COG2378@2|Bacteria,1MX81@1224|Proteobacteria,1T04Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - WYL k59_125747_9 314278.NB231_12836 7.85e-09 59.3 COG5606@1|root,COG5606@2|Bacteria,1NA3S@1224|Proteobacteria,1SE15@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_125747_10 1121939.L861_02140 1.03e-174 501.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RPQR@1236|Gammaproteobacteria,1XI4Z@135619|Oceanospirillales 135619|Oceanospirillales S HipA-like C-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_125747_11 1415755.JQLV01000001_gene3925 8.28e-24 94.0 COG1476@1|root,COG1476@2|Bacteria,1N2TN@1224|Proteobacteria,1S98W@1236|Gammaproteobacteria,1XKKK@135619|Oceanospirillales 135619|Oceanospirillales K DNA-binding protein - - - - - - - - - - - - HTH_3 k59_125747_14 1504981.KO116_1740 5.31e-10 61.6 COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,1RY9R@1236|Gammaproteobacteria,1XH7A@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 k59_47660_1 765912.Thimo_0459 2.15e-70 225.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WVZP@135613|Chromatiales 135613|Chromatiales L reverse transcriptase - - - - - - - - - - - - RVT_1 k59_184226_2 1049564.TevJSym_ba00100 0.0 976.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_184226_3 1049564.TevJSym_ba00120 6.34e-188 538.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1J565@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M zinc metalloprotease rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_184226_4 519989.ECTPHS_08483 1.92e-168 484.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_28286_1 90371.CY43_01865 2.77e-68 232.0 28JKJ@1|root,2Z9DD@2|Bacteria,1MUN2@1224|Proteobacteria,1RQIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage P22-like portal protein - - - - - - - - - - - - P22_portal k59_112550_1 1121405.dsmv_0568 7.6e-98 313.0 COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MINB@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidase M16C associated PREP - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_190406_2 314345.SPV1_06039 3.29e-43 157.0 2E15V@1|root,32WKS@2|Bacteria,1N30I@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_190406_3 1049564.TevJSym_aa02110 1.93e-51 170.0 COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1JBKE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein Slp family slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - ko:K07285 - - - - ko00000 - - - Slp k59_190406_4 1049564.TevJSym_aa02100 1.63e-39 138.0 COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer Membrane Lipoprotein slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - ko:K07285 - - - - ko00000 - - - Slp k59_80331_1 1201293.AKXQ01000003_gene2560 1.64e-53 183.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_86619_4 448385.sce1309 4.61e-72 218.0 COG1942@1|root,COG1942@2|Bacteria,1RDK8@1224|Proteobacteria 1224|Proteobacteria S Tautomerase enzyme Z012_06190 - - - - - - - - - - - Tautomerase_2 k59_119336_1 589865.DaAHT2_1395 3.53e-41 138.0 COG2944@1|root,COG2944@2|Bacteria,1N66H@1224|Proteobacteria,42UQW@68525|delta/epsilon subdivisions,2WQQF@28221|Deltaproteobacteria,2MKNP@213118|Desulfobacterales 28221|Deltaproteobacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_93424_2 391615.ABSJ01000038_gene412 7.19e-27 99.4 2EGU9@1|root,33AKF@2|Bacteria,1NJPN@1224|Proteobacteria 1224|Proteobacteria S Putative addiction module component - - - - - - - - - - - - Unstab_antitox k59_93424_3 46234.ANA_C11883 7.17e-20 84.0 COG3668@1|root,COG3668@2|Bacteria,1G7UC@1117|Cyanobacteria,1HSQF@1161|Nostocales 1117|Cyanobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_177520_3 1249627.D779_0234 4e-112 334.0 COG0438@1|root,COG0438@2|Bacteria,1QF9A@1224|Proteobacteria,1RMDT@1236|Gammaproteobacteria,1WW1R@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_157902_1 335543.Sfum_1942 1.16e-167 492.0 COG0377@1|root,COG0649@1|root,COG0852@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2MR1T@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoBCD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,Oxidored_q6 k59_86620_1 1049564.TevJSym_al00370 1.34e-116 343.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1J54Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_22059_1 439235.Dalk_2228 5.63e-76 243.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2WJMT@28221|Deltaproteobacteria,2MMV2@213118|Desulfobacterales 28221|Deltaproteobacteria F Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3169 PEPCK_ATP k59_14880_1 65393.PCC7424_3523 1.75e-20 99.0 COG2199@1|root,COG3829@1|root,COG4191@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1FZWU@1117|Cyanobacteria,3KHMA@43988|Cyanothece 1117|Cyanobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_145133_1 335543.Sfum_1863 1.53e-101 300.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MQ5V@213462|Syntrophobacterales 28221|Deltaproteobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_80340_1 880072.Desac_1462 1.6e-112 360.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_105944_1 1232683.ADIMK_1377 7.83e-66 209.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,465JZ@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_125771_1 118005.AWNK01000003_gene2219 1.01e-25 106.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria 2|Bacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_125771_2 118005.AWNK01000003_gene2218 1.85e-22 96.3 COG3581@1|root,COG3581@2|Bacteria 2|Bacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_60728_1 177439.DP0244 1.66e-33 121.0 29FA5@1|root,3027T@2|Bacteria,1REEQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_60728_2 1192868.CAIU01000026_gene3650 1.56e-19 84.3 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2TUNB@28211|Alphaproteobacteria,43J7T@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_34873_2 713587.THITH_02965 1.78e-51 168.0 COG2963@1|root,COG2963@2|Bacteria,1RIC7@1224|Proteobacteria,1T54X@1236|Gammaproteobacteria,1X2JY@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_145135_1 118166.JH976537_gene204 8.98e-12 69.7 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales 1117|Cyanobacteria T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_157911_1 933262.AXAM01000050_gene3487 3.29e-34 123.0 COG3688@1|root,COG3688@2|Bacteria,1N1NF@1224|Proteobacteria,42UMH@68525|delta/epsilon subdivisions,2WQJ5@28221|Deltaproteobacteria,2MKZN@213118|Desulfobacterales 28221|Deltaproteobacteria S YacP-like NYN domain - - - ko:K06962 - - - - ko00000 - - - NYN_YacP k59_105947_1 589865.DaAHT2_0431 1.41e-40 140.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2MM12@213118|Desulfobacterales 28221|Deltaproteobacteria O Hsp20/alpha crystallin family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_99275_1 1265505.ATUG01000002_gene1615 5.74e-10 61.2 COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 k59_99275_2 1265505.ATUG01000002_gene1616 7.69e-61 208.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales 28221|Deltaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 k59_164310_1 331678.Cphamn1_0473 3.84e-42 160.0 COG0493@1|root,COG0493@2|Bacteria,1FEHZ@1090|Chlorobi 2|Bacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - FeS,Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3 k59_28298_1 765912.Thimo_1050 5.03e-225 636.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_28298_2 1049564.TevJSym_ai00300 2.09e-53 179.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1J4VW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway, component PulF pilC GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009297,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032940,GO:0033036,GO:0042886,GO:0043711,GO:0044085,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0098776 - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_125776_1 1198232.CYCME_0863 2.88e-39 141.0 2FJPI@1|root,34BCN@2|Bacteria,1P178@1224|Proteobacteria,1SST9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_41613_1 443144.GM21_3075 4.58e-11 60.1 COG2963@1|root,COG2963@2|Bacteria,1N06K@1224|Proteobacteria 1224|Proteobacteria L COG2963, Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_99276_1 1408254.T458_24165 3e-45 158.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26QZ3@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,BPD_transp_1,OppC_N,oligo_HPY k59_80546_1 1121405.dsmv_0775 6.75e-66 214.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_4,Sugar_tr k59_86780_1 679200.HMPREF9333_01847 4.58e-12 71.6 COG2801@1|root,COG2801@2|Bacteria,1TRNK@1239|Firmicutes,24B7I@186801|Clostridia 186801|Clostridia L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_119567_1 335543.Sfum_0752 4.78e-13 68.6 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_190620_1 425400.LS65_01420 6.46e-18 87.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2YMF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_190620_2 439235.Dalk_1794 3.1e-15 76.3 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales 28221|Deltaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_145353_1 1348583.ATLH01000022_gene2237 9.69e-68 219.0 COG1044@1|root,COG1044@2|Bacteria,4NH6I@976|Bacteroidetes,1HXDW@117743|Flavobacteriia,1F7VV@104264|Cellulophaga 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_60933_2 1055815.AYYA01000066_gene1574 1.88e-11 63.9 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,3NJF8@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_106137_1 349521.HCH_06867 8.65e-73 252.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RYVF@1236|Gammaproteobacteria,1XRXC@135619|Oceanospirillales 135619|Oceanospirillales S Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - AAA_29,SbcCD_C k59_73572_1 795666.MW7_1053 6.14e-49 174.0 COG5281@1|root,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,2VIQC@28216|Betaproteobacteria,1K9FA@119060|Burkholderiaceae 28216|Betaproteobacteria L tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_73572_2 314262.MED193_12653 4.51e-19 86.3 COG2958@1|root,COG2958@2|Bacteria,1R6W9@1224|Proteobacteria,2U2HE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K09805 - - - - ko00000 - - - - k59_171313_1 1122599.AUGR01000012_gene902 2.48e-56 192.0 28K8N@1|root,2Z9WC@2|Bacteria,1R5V8@1224|Proteobacteria,1S3I5@1236|Gammaproteobacteria,1XIER@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3549) - - - - - - - - - - - - DUF3549 k59_93666_1 425104.Ssed_2790 1.88e-100 299.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,2Q9RW@267890|Shewanellaceae 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm2 - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_35117_1 706587.Desti_5385 5.25e-91 291.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_151784_1 247490.KSU1_C1150 1.65e-47 165.0 COG0845@1|root,COG0845@2|Bacteria,2IYR9@203682|Planctomycetes 203682|Planctomycetes M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_119568_1 305900.GV64_09180 4.91e-85 263.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1XHTX@135619|Oceanospirillales 135619|Oceanospirillales M Phospholipase pldA - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_86783_1 1123401.JHYQ01000024_gene1252 6.56e-92 274.0 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,45ZZT@72273|Thiotrichales 72273|Thiotrichales O Glutaredoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Glutaredoxin,Redoxin k59_134372_2 1279009.ADICEAN_00283 4.64e-31 119.0 COG2801@1|root,COG2801@2|Bacteria,4NF3Q@976|Bacteroidetes,47NB8@768503|Cytophagia 976|Bacteroidetes L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_147218_1 1121405.dsmv_0071 1.66e-89 275.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2MHP6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyridine nucleotide-disulphide oxidoreductase, FAD NAD(P)-binding domain, pyridine nucleotide-disulfide oxidoreductase dimerization region, FAD-dependent pyridine nucleotide-disulfide oxidoreductase lpdA-1 - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_75496_1 255470.cbdbA1487 1.5e-134 388.0 COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia 301297|Dehalococcoidia L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_153544_2 1049564.TevJSym_ab00160 3.91e-69 213.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1J64K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_69793_2 795359.TOPB45_1626 2.21e-135 394.0 COG0172@1|root,COG0172@2|Bacteria,2GGY4@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_179763_1 106370.Francci3_1018 3.06e-31 123.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales 201174|Actinobacteria L manually curated - - - - - - - - - - - - DDE_3,HTH_32 k59_166387_1 42565.FP66_08115 1.42e-79 253.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_101431_1 933262.AXAM01000004_gene2398 4.1e-70 231.0 COG0457@1|root,COG0683@1|root,COG0457@2|Bacteria,COG0683@2|Bacteria,1R8IG@1224|Proteobacteria,42N7H@68525|delta/epsilon subdivisions,2WIUQ@28221|Deltaproteobacteria,2MHTC@213118|Desulfobacterales 28221|Deltaproteobacteria E Periplasmic binding protein - - - ko:K07121 - - - - ko00000 - - - LppC,Peripla_BP_6,TPR_16,TPR_6 k59_50034_1 1288494.EBAPG3_13600 1.96e-06 46.6 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,373FJ@32003|Nitrosomonadales 28216|Betaproteobacteria S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_50034_2 519989.ECTPHS_06827 2.07e-57 186.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_63224_1 1123368.AUIS01000004_gene120 3.84e-39 147.0 COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_63224_2 1144319.PMI16_00261 4.09e-08 54.7 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHPI@28216|Betaproteobacteria,475S0@75682|Oxalobacteraceae 28216|Betaproteobacteria T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - EAL,GGDEF,HAMP,dCache_3 k59_166389_1 335543.Sfum_0736 9.77e-99 302.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2MQRE@213462|Syntrophobacterales 28221|Deltaproteobacteria E Pyridoxal-phosphate dependent enzyme tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_37333_1 105559.Nwat_0059 9.22e-54 191.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_30485_2 455436.DS989811_gene1797 3.2e-10 63.2 2E645@1|root,330T3@2|Bacteria,1NEGX@1224|Proteobacteria,1SC3K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_153551_1 1121405.dsmv_2821 3.12e-48 167.0 COG2214@1|root,COG2214@2|Bacteria,1RAR9@1224|Proteobacteria,42QSU@68525|delta/epsilon subdivisions,2WN19@28221|Deltaproteobacteria,2MI9S@213118|Desulfobacterales 28221|Deltaproteobacteria O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_153551_2 1120950.KB892784_gene193 6.45e-26 107.0 COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4DNHM@85009|Propionibacteriales 201174|Actinobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_96207_1 338966.Ppro_3708 1.77e-54 181.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_114693_1 1121878.AUGL01000010_gene1034 1.57e-33 121.0 COG1180@1|root,COG1180@2|Bacteria,1RA4Z@1224|Proteobacteria,1S34Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PFAM Radical SAM domain protein - - - - - - - - - - - - Fer4_14,Radical_SAM k59_114693_2 768671.ThimaDRAFT_4596 3.66e-37 134.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria,1WWKB@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_147232_1 1047013.AQSP01000126_gene2727 2.5e-29 105.0 COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria 2|Bacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_160311_2 1049564.TevJSym_ai00180 6.6e-147 423.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1J54T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 PseudoU_synth_2,S4 k59_11250_1 1121403.AUCV01000056_gene3012 1.48e-132 396.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_198516_3 1198452.Jab_2c09110 4.64e-46 171.0 COG0477@1|root,COG0477@2|Bacteria,1QV81@1224|Proteobacteria,2VYU8@28216|Betaproteobacteria,477S4@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Transmembrane secretion effector - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - MFS_1 k59_30489_2 555779.Dthio_PD1324 8.06e-51 164.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,42WCF@68525|delta/epsilon subdivisions,2WRES@28221|Deltaproteobacteria,2MFJ9@213115|Desulfovibrionales 28221|Deltaproteobacteria S Mycobacterial 4 TMS phage holin, superfamily IV - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_30489_3 706587.Desti_1460 4.87e-12 63.5 COG0655@1|root,COG0655@2|Bacteria,1QV9P@1224|Proteobacteria,42RJT@68525|delta/epsilon subdivisions,2WNM5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Flavodoxin domain - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_172730_1 187272.Mlg_0386 4.68e-30 117.0 2C87N@1|root,2ZCQ2@2|Bacteria,1RBNP@1224|Proteobacteria,1S2KA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3800) - - - - - - - - - - - - DUF3800 k59_82556_1 1193729.A1OE_1166 7.34e-38 133.0 COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2U5D3@28211|Alphaproteobacteria,2JT4E@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_55884_2 859657.RPSI07_0307 1.48e-89 269.0 COG1309@1|root,COG1309@2|Bacteria,1NM93@1224|Proteobacteria,2VQGN@28216|Betaproteobacteria,1KHQ2@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_55884_3 1031711.RSPO_c01870 5.18e-133 381.0 COG0778@1|root,COG0778@2|Bacteria,1RBXY@1224|Proteobacteria,2VX6P@28216|Betaproteobacteria,1KFKT@119060|Burkholderiaceae 28216|Betaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_55884_4 1217718.ALOU01000055_gene3516 3.79e-43 160.0 COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,1K1ID@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_55884_5 1122951.ATUE01000006_gene1388 0.0 1360.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,3NIN1@468|Moraxellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138,ko:K18303 ko01501,ko01503,map01501,map01503 M00642,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.17 - - ACR_tran k59_55884_11 317025.Tcr_0334 2.32e-316 897.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,45ZT7@72273|Thiotrichales 72273|Thiotrichales L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_44603_1 338963.Pcar_0359 3.13e-101 317.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,43S73@69541|Desulfuromonadales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_128553_1 879212.DespoDRAFT_00035 8.51e-79 263.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_198519_1 672.VV93_v1c21130 6.54e-14 77.8 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1XV5E@135623|Vibrionales 135623|Vibrionales M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_3996_1 156889.Mmc1_0795 2.91e-14 69.7 COG1309@1|root,COG1309@2|Bacteria,1RF0W@1224|Proteobacteria,2U709@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_3996_2 1049564.TevJSym_aa00840 2.7e-83 254.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1J4RB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141 - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_179972_5 879630.E1A2Q9_9CAUD 0.000108 45.1 4QHMI@10239|Viruses,4QUW2@35237|dsDNA viruses no RNA stage,4QTVD@28883|Caudovirales,4QIHK@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_30688_1 63737.Npun_DF046 2.38e-157 463.0 COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HKMU@1161|Nostocales 1117|Cyanobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_153742_1 272134.KB731325_gene525 5.93e-66 215.0 COG5659@1|root,COG5659@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - DDE_5 k59_140696_2 1049564.TevJSym_aa01740 1.97e-208 593.0 COG1226@1|root,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,Na_H_Exchanger,TrkA_C,TrkA_N k59_82751_1 1499967.BAYZ01000017_gene6233 7.58e-104 308.0 COG0693@1|root,COG0693@2|Bacteria 2|Bacteria S protein deglycation - - - - - - - - - - - - DJ-1_PfpI,ThiJ_like k59_82751_2 1463861.JNXE01000002_gene6555 2.04e-18 90.5 COG5485@1|root,COG5485@2|Bacteria,2IEYF@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_82751_3 29495.EA26_08825 3.65e-46 152.0 COG3631@1|root,COG3631@2|Bacteria 2|Bacteria S light absorption - - - - - - - - - - - - SnoaL,SnoaL_2 k59_82751_4 29495.EA26_08830 6.02e-100 293.0 COG0693@1|root,COG0693@2|Bacteria,1QTGZ@1224|Proteobacteria,1SVZC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_82751_5 1184609.KILIM_090_00160 1.17e-74 226.0 COG0346@1|root,COG0346@2|Bacteria,2IHCN@201174|Actinobacteria 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K08234 - - - - ko00000 - - - Glyoxalase,Glyoxalase_4 k59_82751_6 573061.Clocel_1101 2.02e-294 828.0 COG2942@1|root,COG2942@2|Bacteria,1USA9@1239|Firmicutes,24YSW@186801|Clostridia 186801|Clostridia G 2-epimerase - - - - - - - - - - - - - k59_82751_7 582515.KR51_00004660 3.52e-150 445.0 COG1523@1|root,COG1523@2|Bacteria,1G0PW@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_4192_1 82995.CR62_08025 4.47e-72 251.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,3ZZIT@613|Serratia 1236|Gammaproteobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_89047_1 1236517.BAKO01000098_gene539 4.15e-05 50.8 COG3464@1|root,COG3464@2|Bacteria,4NY0R@976|Bacteroidetes,2FU92@200643|Bacteroidia 976|Bacteroidetes L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3 k59_101660_1 1195246.AGRI_05102 2.4e-14 71.6 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,466JV@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2500,iBWG_1329.BWG_2264,iECDH10B_1368.ECDH10B_2666,iECDH1ME8569_1439.ECDH1ME8569_2426,iEcDH1_1363.EcDH1_1169,iJO1366.b2500,iJR904.b2500,iY75_1357.Y75_RS13050 Formyl_trans_N k59_205564_1 1165841.SULAR_03817 2.61e-82 269.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_140698_1 59894.ENSFALP00000010796 2.48e-09 59.3 2CHIC@1|root,2QWKE@2759|Eukaryota,38DAH@33154|Opisthokonta,3BJXB@33208|Metazoa,3D3WI@33213|Bilateria,482RR@7711|Chordata,499BM@7742|Vertebrata,4GUUS@8782|Aves 33208|Metazoa S protein C1orf50 homolog C1orf50 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - - - - - - - - - - DUF2452 k59_140698_2 631362.Thi970DRAFT_03885 3.62e-47 157.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1WXHM@135613|Chromatiales 135613|Chromatiales IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_70099_2 765912.Thimo_1116 1.55e-35 129.0 29WEY@1|root,30I0T@2|Bacteria,1RGK1@1224|Proteobacteria,1S5PH@1236|Gammaproteobacteria,1WY8Q@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4381) - - - - - - - - - - - - DUF4381 k59_70099_3 1049564.TevJSym_bh00110 1.44e-145 420.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1J577@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_186907_1 1049564.TevJSym_bl00140 4.93e-261 721.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_56081_1 933262.AXAM01000014_gene275 2.43e-77 246.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_24549_1 323261.Noc_0132 3.9e-24 102.0 2DBSQ@1|root,2ZATE@2|Bacteria,1N58C@1224|Proteobacteria,1SAPH@1236|Gammaproteobacteria,1X12X@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_24549_2 395495.Lcho_0656 5.77e-43 144.0 COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,2VITQ@28216|Betaproteobacteria,1KN4K@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Conserved hypothetical ATP binding protein - - - ko:K06945 - - - - ko00000 - - - ATP_bind_1 k59_186908_2 391615.ABSJ01000050_gene1235 3.36e-47 153.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1J6FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU PilZ domain pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_166626_1 861299.J421_1867 2.34e-92 294.0 COG1429@1|root,COG1429@2|Bacteria 2|Bacteria H ligase activity, forming nitrogen-metal bonds cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel,Glyco_hydro_63 k59_50256_1 631362.Thi970DRAFT_03510 6.68e-06 48.5 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales 135613|Chromatiales O TIGRFAM Cytochrome c-type biogenesis protein CcmI - - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_50256_2 1341157.RF007C_06285 0.000447 45.4 COG0480@1|root,COG3688@1|root,COG0480@2|Bacteria,COG3688@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,3WH08@541000|Ruminococcaceae 186801|Clostridia J elongation factor G tetP - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP k59_13606_1 933262.AXAM01000030_gene822 2.93e-10 60.1 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R7R@68525|delta/epsilon subdivisions,2WMT0@28221|Deltaproteobacteria,2MJMX@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - GerE,HATPase_c,HisKA,PAS,Response_reg k59_13606_2 1304885.AUEY01000033_gene1921 7.91e-33 124.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WP0E@28221|Deltaproteobacteria,2MJVK@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_156263_1 1121448.DGI_0817 2.25e-12 72.4 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE,DUF3365,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_136820_1 765910.MARPU_08750 4.24e-65 206.0 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM conserved - - - - - - - - - - - - DUF2461 k59_130399_1 584708.Apau_0641 7.21e-24 102.0 COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,3TBVJ@508458|Synergistetes 508458|Synergistetes Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_130399_2 1121878.AUGL01000017_gene1760 6.7e-26 103.0 2E69N@1|root,330XJ@2|Bacteria,1R3JE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_143270_2 420662.Mpe_A3251 7.88e-48 168.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,1KIZI@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Lipid A biosynthesis acyltransferase htrB_2 - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_143270_3 1049564.TevJSym_ab00910 9.53e-202 585.0 COG2304@1|root,COG2304@2|Bacteria,1MVJ2@1224|Proteobacteria,1RMUF@1236|Gammaproteobacteria,1J5FC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S von Willebrand factor type A domain - - - - - - - - - - - - VWA,VWA_3 k59_143270_5 768671.ThimaDRAFT_0729 4.33e-17 74.7 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1WYK5@135613|Chromatiales 135613|Chromatiales S PFAM Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_182234_1 1232437.KL662064_gene4059 3.47e-111 335.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42NWT@68525|delta/epsilon subdivisions,2X5DA@28221|Deltaproteobacteria,2MMYJ@213118|Desulfobacterales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_169203_1 1278309.KB907103_gene1051 5.63e-22 92.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1XHIX@135619|Oceanospirillales 135619|Oceanospirillales L exodeoxyribonuclease III xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_169203_2 1049564.TevJSym_ab00680 1.37e-118 346.0 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,1RMTD@1236|Gammaproteobacteria,1J4EP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0246 family yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_169203_3 1123368.AUIS01000003_gene1770 3.47e-104 310.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,2NCWV@225057|Acidithiobacillales 225057|Acidithiobacillales L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_52513_1 391615.ABSJ01000030_gene806 7.76e-23 96.3 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1J4MQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_52513_2 1049564.TevJSym_ah00720 1.03e-100 301.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1J5NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_52513_3 1049564.TevJSym_ah00710 3.28e-89 270.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1J4GT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_104349_1 765911.Thivi_2803 1.97e-156 443.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1X0I7@135613|Chromatiales 135613|Chromatiales S CbbQ/NirQ/NorQ C-terminal - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_123873_1 879212.DespoDRAFT_00528 6.25e-20 87.8 COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MJJ0@213118|Desulfobacterales 28221|Deltaproteobacteria S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_65521_1 416269.APL_0787 2.68e-48 169.0 COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,1RYD6@1236|Gammaproteobacteria,1Y7HT@135625|Pasteurellales 135625|Pasteurellales S AAA domain - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_39522_1 1419583.V466_24045 3.12e-35 124.0 COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,1SCNB@1236|Gammaproteobacteria,1YQBU@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Protein of unknown function (DUF423) ygdD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF423 k59_26667_2 1173028.ANKO01000017_gene217 9.27e-237 671.0 COG0028@1|root,COG0028@2|Bacteria,1G2XN@1117|Cyanobacteria 1117|Cyanobacteria EH Belongs to the TPP enzyme family - - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_26667_3 1184609.KILIM_090_00100 3.01e-101 298.0 COG0693@1|root,COG0693@2|Bacteria,2I8UU@201174|Actinobacteria 201174|Actinobacteria EGP ThiJ/PfpI family-like - - - - - - - - - - - - ThiJ_like k59_188688_1 1123371.ATXH01000013_gene1529 1.53e-131 382.0 COG0152@1|root,COG0152@2|Bacteria,2GH07@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_188692_1 886293.Sinac_6050 3.24e-34 131.0 2DMFF@1|root,32R5F@2|Bacteria 2|Bacteria S IMG reference gene - - - - - - - - - - - - - k59_104359_1 945713.IALB_0542 1.47e-103 308.0 COG0181@1|root,COG0181@2|Bacteria 2|Bacteria H hydroxymethylbilane synthase activity hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 ko:K01749,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R03165,R03194 RC00003,RC00871,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iHN637.CLJU_RS15760,iPC815.YPO3849 Porphobil_deam,Porphobil_deamC k59_149837_1 380394.Lferr_0287 4.72e-35 135.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_156488_1 96561.Dole_0013 4.9e-77 246.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_175909_1 713586.KB900536_gene83 8e-29 112.0 COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,1WZ46@135613|Chromatiales 135613|Chromatiales S PFAM electron transport protein SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_26930_2 768671.ThimaDRAFT_2574 2.31e-108 327.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales 135613|Chromatiales T response regulator glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_72262_1 575540.Isop_3290 2.83e-17 85.5 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_143525_1 1380390.JIAT01000010_gene3702 1.63e-23 105.0 COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4CS9K@84995|Rubrobacteria 84995|Rubrobacteria T Histidine kinase - - - - - - - - - - - - GAF,HisKA_3 k59_201968_1 349521.HCH_05420 2.53e-40 139.0 2D3H4@1|root,32TEZ@2|Bacteria,1MYWS@1224|Proteobacteria,1S858@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_201968_2 1366050.N234_24410 1.07e-12 67.8 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,2VHJ7@28216|Betaproteobacteria,1K18B@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM SpoVR family protein spoVR2 - - ko:K06415 - - - - ko00000 - - - SpoVR k59_810_1 1121405.dsmv_0048 6.53e-110 330.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJF9@28221|Deltaproteobacteria,2MHRZ@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_7454_1 314225.ELI_14895 1.77e-36 125.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2K5CA@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_104584_1 289376.THEYE_A1271 9.35e-23 94.0 COG1801@1|root,COG1801@2|Bacteria 2|Bacteria L Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_182510_1 760192.Halhy_1923 3.31e-63 207.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_195219_1 522772.Dacet_2541 2.64e-26 104.0 COG1024@1|root,COG1024@2|Bacteria,2GFDF@200930|Deferribacteres 200930|Deferribacteres I enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_33319_1 880072.Desac_0544 1.11e-110 353.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_39812_1 251229.Chro_3991 1.86e-25 101.0 COG0500@1|root,COG2226@2|Bacteria,1G3V3@1117|Cyanobacteria,3VKIZ@52604|Pleurocapsales 1117|Cyanobacteria Q COGs COG2226 Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_65735_1 1049564.TevJSym_ac00320 1.22e-201 577.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,1RQCS@1236|Gammaproteobacteria,1J71N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_163010_1 177437.HRM2_23710 3.04e-12 65.9 COG1633@1|root,COG1633@2|Bacteria,1MY6B@1224|Proteobacteria,42TCR@68525|delta/epsilon subdivisions,2WP9M@28221|Deltaproteobacteria,2MKDD@213118|Desulfobacterales 28221|Deltaproteobacteria S Ferritin-like domain - - - - - - - - - - - - Rubrerythrin k59_163010_2 865938.Weevi_0380 5.53e-24 101.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,1HXN0@117743|Flavobacteriia 976|Bacteroidetes C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_13774_1 1294142.CINTURNW_0226 1.36e-47 171.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae 186801|Clostridia S CBS domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_13774_2 765913.ThidrDRAFT_0850 1.61e-32 129.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales 135613|Chromatiales P PFAM Na Picotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_78911_2 411684.HPDFL43_15712 6.93e-11 65.9 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,43HT4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Inositol monophosphatase hisN - 3.1.3.15,3.1.3.25,3.1.3.93 ko:K01092,ko:K18649 ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00114,M00131 R01185,R01186,R01187,R03013,R07674 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_124105_4 1458275.AZ34_15930 2.61e-158 461.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9V8@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator yfhA - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_117674_1 880072.Desac_0433 3.08e-78 242.0 COG0589@1|root,COG0589@2|Bacteria,1N6DC@1224|Proteobacteria,42UXA@68525|delta/epsilon subdivisions,2WQF5@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_169497_1 1120953.AUBH01000005_gene2477 4.93e-81 257.0 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,46D8K@72275|Alteromonadaceae 1236|Gammaproteobacteria I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_26937_1 1049564.TevJSym_ak00560 2.12e-146 438.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_46230_1 1049564.TevJSym_ad00780 2.55e-141 416.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_175922_1 500632.CLONEX_00944 2.91e-24 97.4 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_175922_2 880072.Desac_1442 2.09e-44 147.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2MQJ8@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_78915_1 1207063.P24_02001 4.81e-81 247.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2JPSB@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein, beta subunit etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_39822_2 237368.SCABRO_02415 4.87e-60 197.0 COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes 203682|Planctomycetes P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_91637_1 335543.Sfum_1184 1.39e-63 213.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - - k59_124108_1 1198452.Jab_1c02300 4.39e-35 129.0 COG0619@1|root,COG0619@2|Bacteria,1R4KM@1224|Proteobacteria,2VQX3@28216|Betaproteobacteria 28216|Betaproteobacteria P Cobalt transport protein - - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_124108_2 1304883.KI912532_gene999 2.89e-44 147.0 COG1930@1|root,COG1930@2|Bacteria,1RK68@1224|Proteobacteria,2VUH8@28216|Betaproteobacteria,2KXHU@206389|Rhodocyclales 206389|Rhodocyclales P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiN - - ko:K02009 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18 - - CbiN k59_124108_3 1304883.KI912532_gene1000 1.55e-60 192.0 COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria,2VNDD@28216|Betaproteobacteria,2KV2J@206389|Rhodocyclales 206389|Rhodocyclales P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiM - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_59314_1 981369.JQMJ01000004_gene2240 2.27e-79 258.0 COG2303@1|root,COG2303@2|Bacteria,2GK9F@201174|Actinobacteria,2NF2F@228398|Streptacidiphilus 201174|Actinobacteria E GMC oxidoreductase choE - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_59314_2 1192759.AKIB01000051_gene943 1.17e-35 134.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K24H@204457|Sphingomonadales 204457|Sphingomonadales L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_182527_1 665571.STHERM_c14100 2.22e-11 66.2 COG0232@1|root,COG0232@2|Bacteria,2J69E@203691|Spirochaetes 203691|Spirochaetes F PFAM Metal-dependent phosphohydrolase, HD dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_169503_1 1049564.TevJSym_ba00080 5.75e-72 231.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1J4TE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_117678_1 765910.MARPU_13570 7.72e-73 238.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_117678_2 765912.Thimo_0764 2.26e-106 316.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator, LysR - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_137058_1 517418.Ctha_0920 6.41e-105 309.0 COG1117@1|root,COG1117@2|Bacteria 2|Bacteria P ATPase-coupled phosphate ion transmembrane transporter activity pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_7470_1 686578.AFFX01000001_gene1545 5.91e-81 262.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_20298_1 335543.Sfum_0808 1.84e-48 166.0 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MSDJ@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_13787_1 768671.ThimaDRAFT_1391 1.04e-14 70.1 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales 135613|Chromatiales S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_13787_2 1049564.TevJSym_ak00860 1.58e-80 249.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1J55A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Arabinose 5-phosphate isomerase kdsD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4519,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iPC815.YPO3577,iSFV_1184.SFV_3227,iSFxv_1172.SFxv_3550,iYL1228.KPN_03607,iZ_1308.Z4560 CBS,SIS k59_26946_1 1049564.TevJSym_bs00020 6.44e-44 157.0 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_150116_4 640081.Dsui_2250 3.58e-135 401.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1R53C@1224|Proteobacteria,2VNCZ@28216|Betaproteobacteria,2KW0J@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_150116_6 1049564.TevJSym_bi00340 9.77e-63 195.0 COG0517@1|root,COG0517@2|Bacteria,1R28V@1224|Proteobacteria,1T5JI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_169505_1 335543.Sfum_2174 1.64e-170 492.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MQSK@213462|Syntrophobacterales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_201990_1 706587.Desti_4262 3.2e-14 72.8 COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 k59_191200_5 1396858.Q666_08385 5.18e-85 254.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,466UU@72275|Alteromonadaceae 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010604,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031437,GO:0031439,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903311,GO:1903313,GO:1903506,GO:2000112,GO:2001141 - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_191200_6 1441930.Z042_14840 8.51e-67 208.0 COG3797@1|root,COG3797@2|Bacteria,1PUJV@1224|Proteobacteria,1SXU1@1236|Gammaproteobacteria,404WJ@613|Serratia 1236|Gammaproteobacteria S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 k59_106880_1 933262.AXAM01000038_gene896 2.01e-66 209.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2MIKY@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_126920_1 335543.Sfum_3188 1.24e-14 71.6 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,42TJR@68525|delta/epsilon subdivisions,2WRDG@28221|Deltaproteobacteria,2MQQB@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_126920_2 335543.Sfum_3187 1.48e-37 127.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2MS6A@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_22807_1 1547437.LL06_18885 1.19e-15 75.5 COG3620@1|root,COG3620@2|Bacteria,1MYVA@1224|Proteobacteria,2UI2K@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 k59_22807_2 1219072.VHA01S_046_00190 2.55e-24 95.9 COG4453@1|root,COG4453@2|Bacteria,1N0BK@1224|Proteobacteria,1S8UN@1236|Gammaproteobacteria,1XYE0@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_22807_3 641524.ADICYQ_2317 3.25e-54 183.0 COG3177@1|root,COG3177@2|Bacteria,4NH7D@976|Bacteroidetes 976|Bacteroidetes S Pfam Fic DOC family - - - - - - - - - - - - Fic k59_81183_1 1121405.dsmv_1458 7.64e-125 371.0 COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales 28221|Deltaproteobacteria I Carboxyl transferase domain gcdA - 4.1.1.70 ko:K01615 ko00362,ko00650,ko01120,map00362,map00650,map01120 - R03028 RC00832 ko00000,ko00001,ko01000,ko02000 3.B.1.1.3 - - Carboxyl_trans k59_126924_1 96561.Dole_0344 2.92e-60 206.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB-2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_100032_1 2340.JV46_17900 1.23e-29 108.0 COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_100032_2 1049564.TevJSym_ah00230 6.32e-243 674.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1J4R1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2368 Seryl_tRNA_N,tRNA-synt_2b k59_100032_4 1049564.TevJSym_ah00250 3.07e-83 253.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1JA0E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Inhibitor of apoptosis-promoting Bax1 yccA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090 - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_158776_1 1278307.KB906978_gene3791 9.01e-43 159.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RRGT@1236|Gammaproteobacteria,2QJ18@267894|Psychromonadaceae 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE3,DUF3369,HATPase_c,HisKA,Response_reg k59_94547_1 335543.Sfum_0642 1.18e-77 246.0 COG4191@1|root,COG4191@2|Bacteria,1MY5P@1224|Proteobacteria,42MTA@68525|delta/epsilon subdivisions,2WJ9Q@28221|Deltaproteobacteria,2MR6C@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - 4HB_MCP_1,CHASE3,HAMP,HATPase_c,HisKA k59_106889_1 439235.Dalk_1371 4.49e-129 384.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_42663_2 1049564.TevJSym_an00380 7.44e-84 262.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J4EJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the pyruvate kinase family pykA GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 PK,PK_C k59_29017_1 992406.RIA_2052 1.18e-28 107.0 COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1HYH3@117743|Flavobacteriia 976|Bacteroidetes L DNA-3-methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_138965_1 933262.AXAM01000055_gene1260 6.14e-107 322.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2MHTS@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1,NUDIX k59_152265_1 1469245.JFBG01000008_gene758 2.32e-64 211.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_35785_2 96561.Dole_2613 1.03e-59 189.0 COG1592@1|root,COG1592@2|Bacteria,1RCBN@1224|Proteobacteria,42QSP@68525|delta/epsilon subdivisions,2WMSS@28221|Deltaproteobacteria,2MJJU@213118|Desulfobacterales 28221|Deltaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_94758_1 498211.CJA_0589 2.76e-42 166.0 COG2982@1|root,COG2982@2|Bacteria,1QVU8@1224|Proteobacteria,1T2J0@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - He_PIG,OMP_b-brl k59_94758_2 1345695.CLSA_c32650 7.24e-07 53.1 COG4191@1|root,COG4191@2|Bacteria,1UM8G@1239|Firmicutes,25GC2@186801|Clostridia 186801|Clostridia T Membrane-associated sensor domain - - - - - - - - - - - - HATPase_c,MASE3 k59_54881_1 1121405.dsmv_3796 2e-126 375.0 COG3316@1|root,COG3316@2|Bacteria,1QWDK@1224|Proteobacteria,43CXP@68525|delta/epsilon subdivisions,2X85T@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66 k59_48727_1 335543.Sfum_0797 1.38e-46 166.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MQU1@213462|Syntrophobacterales 68525|delta/epsilon subdivisions C PFAM 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - DUF4445,Fer2 k59_178578_1 1121396.KB892913_gene116 1.03e-48 168.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales 28221|Deltaproteobacteria S Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_54883_2 1123371.ATXH01000012_gene1456 1.89e-75 236.0 COG0778@1|root,COG0778@2|Bacteria,2GHT9@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_29157_1 765911.Thivi_3343 6.17e-159 456.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_152358_2 999411.HMPREF1092_00693 1.48e-39 150.0 COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HD,HD_5,PAS,PAS_4,PAS_8 k59_68313_1 203122.Sde_2340 2.3e-85 268.0 2CCCE@1|root,32V9R@2|Bacteria,1N4YI@1224|Proteobacteria,1STWC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_171976_2 1502852.FG94_03815 1.93e-78 244.0 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria,4777A@75682|Oxalobacteraceae 28216|Betaproteobacteria S Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_171976_3 243231.GSU1539 2.25e-104 309.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,43T0E@69541|Desulfuromonadales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_9926_1 1265505.ATUG01000002_gene2391 9.14e-155 436.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 k59_74219_3 272624.lpg2911 1.41e-42 164.0 COG2939@1|root,COG2939@2|Bacteria,1Q92K@1224|Proteobacteria,1T6SV@1236|Gammaproteobacteria,1JE6M@118969|Legionellales 118969|Legionellales M Serine carboxypeptidase - - 3.4.16.5 ko:K13289 ko04142,ko04614,map04142,map04614 - - - ko00000,ko00001,ko01000,ko01002,ko03110,ko04131,ko04147 - - - Peptidase_S10 k59_15764_1 765913.ThidrDRAFT_0840 1.7e-99 308.0 COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,1MXFN@1224|Proteobacteria,1RMZC@1236|Gammaproteobacteria,1X07M@135613|Chromatiales 135613|Chromatiales G TIGRFAM Phosphotransferase system, fructose IIC component - - - - - - - - - - - - PTS_IIB k59_15764_2 765913.ThidrDRAFT_0839 3.36e-143 413.0 COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,1RP6K@1236|Gammaproteobacteria,1X2EI@135613|Chromatiales 135613|Chromatiales H belongs to the carbohydrate kinase PfkB family - - - - - - - - - - - - PfkB k59_158948_2 349521.HCH_05414 1.68e-50 173.0 COG2304@1|root,COG2304@2|Bacteria,1RGCN@1224|Proteobacteria,1S5GI@1236|Gammaproteobacteria,1XPSH@135619|Oceanospirillales 135619|Oceanospirillales S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 k59_204203_1 330084.JNYZ01000022_gene3803 9.94e-47 169.0 COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4E27Y@85010|Pseudonocardiales 201174|Actinobacteria C Cytokinin dehydrogenase 1, FAD and cytokinin binding - - - - - - - - - - - - Cytokin-bind,FAD_binding_4 k59_204203_3 1265313.HRUBRA_01991 0.000399 43.1 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,1RRE0@1236|Gammaproteobacteria,1J5JG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C and related enzymes - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_74221_1 713586.KB900536_gene2496 7.75e-46 160.0 COG0392@1|root,COG0392@2|Bacteria,1N8EI@1224|Proteobacteria,1S99A@1236|Gammaproteobacteria,1X0SH@135613|Chromatiales 135613|Chromatiales S lysyltransferase activity - - - - - - - - - - - - - k59_127172_1 404589.Anae109_3714 7.87e-42 139.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_81349_3 1000565.METUNv1_03745 1.22e-130 380.0 COG0476@1|root,COG0476@2|Bacteria,1QUMS@1224|Proteobacteria,2VN2Y@28216|Betaproteobacteria,2KUIK@206389|Rhodocyclales 206389|Rhodocyclales H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 - - - - - - - - - - - - ThiF k59_133230_1 204773.HEAR1468 3.05e-60 200.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,473G9@75682|Oxalobacteraceae 28216|Betaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_22925_1 1121405.dsmv_1954 3.48e-47 159.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MJ2R@213118|Desulfobacterales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1,1.2.7.7 ko:K00170,ko:K00187 ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R07160,R08034,R08566,R08567 RC00004,RC00250,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_22925_2 1125863.JAFN01000001_gene2834 2.95e-07 52.8 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_35966_1 99598.Cal7507_3737 4.71e-19 86.7 COG3299@1|root,COG3299@2|Bacteria,1G3VV@1117|Cyanobacteria 1117|Cyanobacteria S protein, phage tail-like region - - - - - - - - - - - - Baseplate_J k59_35966_2 926560.KE387023_gene1991 3.09e-35 124.0 COG3628@1|root,COG3628@2|Bacteria 2|Bacteria - - - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k59_35966_3 448385.sce2096 6.6e-48 155.0 2CE1N@1|root,32RYY@2|Bacteria,1PNV2@1224|Proteobacteria,4357N@68525|delta/epsilon subdivisions,2WZIQ@28221|Deltaproteobacteria,2Z28B@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_35966_4 666681.M301_2206 9.96e-34 124.0 COG3501@1|root,COG3501@2|Bacteria,1R540@1224|Proteobacteria,2VS00@28216|Betaproteobacteria 28216|Betaproteobacteria S Baseplate assembly protein - - - - - - - - - - - - - k59_35966_5 114615.BRADO4381 1.74e-106 325.0 COG3500@1|root,COG3500@2|Bacteria,1Q2U5@1224|Proteobacteria,2U6FR@28211|Alphaproteobacteria,3K3VD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Late control gene D protein - - - - - - - - - - - - - k59_35966_6 448385.sce2093 6.26e-13 64.3 COG1652@1|root,COG1652@2|Bacteria,1N0XA@1224|Proteobacteria,435I8@68525|delta/epsilon subdivisions,2WZVX@28221|Deltaproteobacteria,2Z2UY@29|Myxococcales 28221|Deltaproteobacteria S LysM domain - - - - - - - - - - - - - k59_74225_2 1120948.KB903217_gene1410 1.29e-12 63.2 COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4E6MN@85010|Pseudonocardiales 201174|Actinobacteria K TIGRFAM DNA binding domain, excisionase family xis - - - - - - - - - - - HTH_17 k59_74225_3 1236976.JCM16418_789 8.22e-28 104.0 2FB2B@1|root,34390@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_139139_1 1125863.JAFN01000001_gene802 3.51e-138 410.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_185218_1 439235.Dalk_1445 4.06e-107 341.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MHZ6@213118|Desulfobacterales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_94782_1 558169.AGAV01000031_gene3359 0.000349 49.3 COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,4HDFR@91061|Bacilli 91061|Bacilli L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_158960_1 332101.JIBU02000048_gene3628 7.87e-48 160.0 COG0655@1|root,COG0655@2|Bacteria,1V2A8@1239|Firmicutes,24G7D@186801|Clostridia,36I9P@31979|Clostridiaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_35970_1 562973.HMPREF0059_00440 4.08e-48 167.0 COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4D39S@85005|Actinomycetales 201174|Actinobacteria S ATPase family associated with various cellular activities (AAA) moxR2 - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_165246_1 396588.Tgr7_0950 2.12e-98 304.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales 135613|Chromatiales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_165246_3 472759.Nhal_3499 2.33e-24 94.7 COG0724@1|root,COG0724@2|Bacteria,1NDEM@1224|Proteobacteria,1SFDX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM RNA recognition motif - - - - - - - - - - - - RRM_1 k59_165246_4 998674.ATTE01000001_gene1024 2.43e-24 93.2 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,46183@72273|Thiotrichales 72273|Thiotrichales K 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_165246_5 290512.Paes_2153 1.21e-121 352.0 COG0518@1|root,COG0518@2|Bacteria,1FE7U@1090|Chlorobi 1090|Chlorobi F PFAM glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_29173_1 1232437.KL661976_gene4974 1.36e-68 220.0 COG0484@1|root,COG0484@2|Bacteria,1R1BK@1224|Proteobacteria,43D8A@68525|delta/epsilon subdivisions,2X8EW@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Class III cytochrome C family - - - - - - - - - - - - Cytochrom_CIII k59_185225_1 1049564.TevJSym_aj00240 4.16e-126 369.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1J5BU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_152381_1 525897.Dbac_0926 9.58e-12 64.3 COG0600@1|root,COG0600@2|Bacteria,1N0FV@1224|Proteobacteria,43BJT@68525|delta/epsilon subdivisions,2X5VX@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K15599 ko02010,map02010 M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 - - BPD_transp_1 k59_152381_2 525897.Dbac_0925 1.47e-43 151.0 COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,42M17@68525|delta/epsilon subdivisions,2WMCN@28221|Deltaproteobacteria 28221|Deltaproteobacteria P NMT1/THI5 like - - - ko:K15598 ko02010,map02010 M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 - - NMT1 k59_146248_1 1049564.TevJSym_bg00170 3.56e-37 127.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1J6PI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_146248_2 768671.ThimaDRAFT_1585 6.61e-144 416.0 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,1RYHJ@1236|Gammaproteobacteria,1WXZG@135613|Chromatiales 135613|Chromatiales K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_89550_1 45351.EDO41218 5.42e-21 91.7 COG0039@1|root,KOG1496@2759|Eukaryota,38G9H@33154|Opisthokonta,3BCK0@33208|Metazoa 33208|Metazoa C Malate dehydrogenase MDH1 GO:0000166,GO:0003674,GO:0003824,GO:0004470,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006091,GO:0006094,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016051,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019318,GO:0019319,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0036094,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046364,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576 1.1.1.37 ko:K00025 ko00020,ko00270,ko00620,ko00630,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04964,map00020,map00270,map00620,map00630,map00710,map01100,map01110,map01120,map01130,map01200,map04964 M00009,M00011,M00012,M00168,M00171 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_89550_2 375286.mma_1948 2.24e-163 470.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,2W0HG@28216|Betaproteobacteria,4727U@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4478) - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_12137_1 550540.Fbal_0035 1.9e-40 141.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily yrdA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 - - - - - - - - - - Hexapep k59_12137_2 1026882.MAMP_02151 1.35e-63 199.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,460MN@72273|Thiotrichales 72273|Thiotrichales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_56560_3 471854.Dfer_0837 2.14e-18 83.6 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,47Q96@768503|Cytophagia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_148085_1 1049564.TevJSym_ax00240 2.95e-106 335.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1JC1F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - 4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_173386_1 933262.AXAM01000051_gene2986 1.1e-58 198.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales 28221|Deltaproteobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_122986_1 1029823.AFIE01000100_gene3655 3.88e-05 53.9 COG3464@1|root,COG3464@2|Bacteria,1N2KA@1224|Proteobacteria,1RQVJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_161123_1 1122194.AUHU01000005_gene960 4.24e-195 554.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,466QE@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3344 Retron-type reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_154325_1 1521187.JPIM01000075_gene2837 4.57e-111 338.0 COG0366@1|root,COG0366@2|Bacteria,2G7QC@200795|Chloroflexi,376X0@32061|Chloroflexia 32061|Chloroflexia G SMART alpha amylase, catalytic sub domain - - 2.4.1.4 ko:K05341 ko00500,map00500 - R01823 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_56564_2 317025.Tcr_1091 2.99e-71 225.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,460B4@72273|Thiotrichales 72273|Thiotrichales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_17801_1 717785.HYPMC_1744 3.87e-71 233.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria,3N6ST@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_135169_1 1049564.TevJSym_aa00080 8.46e-141 400.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1J4GK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_56565_2 257310.BB0808 9.45e-87 259.0 2BJSR@1|root,32E4W@2|Bacteria,1RH3N@1224|Proteobacteria,2W200@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2778) - - - - - - - - - - - - DUF2778 k59_161129_1 1121405.dsmv_1519 1.88e-85 263.0 COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria,2MHKX@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_154332_1 1307759.JOMJ01000003_gene1353 4.61e-10 63.9 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MHC1@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg,SBP_bac_3,sCache_3_2 k59_154332_2 313612.L8106_05311 4.85e-08 55.1 COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHU4@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - ko:K19694 - - - - ko00000,ko01001,ko02022 - - - 7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,dCache_1 k59_135173_1 395493.BegalDRAFT_0885 9.43e-100 303.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,45ZWZ@72273|Thiotrichales 72273|Thiotrichales O PFAM Peptidase family M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_70753_3 1232683.ADIMK_1391 4.96e-30 123.0 COG0369@1|root,COG3182@1|root,COG0369@2|Bacteria,COG3182@2|Bacteria,1MWYV@1224|Proteobacteria,1RY05@1236|Gammaproteobacteria,465H6@72275|Alteromonadaceae 1236|Gammaproteobacteria P Flavodoxin cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,FAD_binding_6,Flavodoxin_1,NAD_binding_1,PepSY_TM k59_199388_1 335543.Sfum_2466 8.78e-60 204.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MR9S@213462|Syntrophobacterales 28221|Deltaproteobacteria C CoA binding domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_129409_1 880072.Desac_1217 1.71e-116 355.0 COG0466@1|root,COG0466@2|Bacteria,1R6HF@1224|Proteobacteria,42QHZ@68525|delta/epsilon subdivisions,2WJNZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Response regulator receiver - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,Lon_C,Response_reg k59_64033_2 946483.Cenrod_1961 7.31e-48 169.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,4AJA8@80864|Comamonadaceae 28216|Betaproteobacteria L Group II intron, maturase-specific domain - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,Intron_maturas2,RVT_1 k59_161130_1 1502851.FG93_05502 5.61e-40 146.0 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,2TU8N@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_161130_2 1536769.P40081_28605 2.59e-93 282.0 COG0175@1|root,COG0175@2|Bacteria,1TZYA@1239|Firmicutes,4I97T@91061|Bacilli,27157@186822|Paenibacillaceae 91061|Bacilli EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_161130_3 702113.PP1Y_AT32175 6.31e-09 58.5 COG0175@1|root,COG0175@2|Bacteria,1NTRW@1224|Proteobacteria,2UPMD@28211|Alphaproteobacteria,2K3T4@204457|Sphingomonadales 204457|Sphingomonadales EH sulfate reduction - - - - - - - - - - - - - k59_193177_1 1121405.dsmv_2142 2.29e-66 224.0 COG2114@1|root,COG2114@2|Bacteria,1NQPW@1224|Proteobacteria 1224|Proteobacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - - k59_83265_1 439235.Dalk_2894 2.22e-74 245.0 COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,PAS,PAS_3,PAS_9,Response_reg k59_206089_3 1208920.CONE_0461 2.27e-08 62.4 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,1KPRQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_206089_4 756280.M4PSL5_9CAUD 1.92e-11 71.6 4QDTA@10239|Viruses,4QXN5@35237|dsDNA viruses no RNA stage,4QUAN@28883|Caudovirales,4QIEV@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_206089_5 1250232.JQNJ01000001_gene2918 1.69e-107 337.0 COG5511@1|root,COG5511@2|Bacteria 2|Bacteria F Phage portal protein, lambda family JD73_18735 - - - - - - - - - - - Phage_portal_2 k59_129413_1 880072.Desac_0544 5.46e-91 296.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_115475_1 1232437.KL661953_gene2313 5.49e-09 55.1 COG0426@1|root,COG0426@2|Bacteria,1RKK1@1224|Proteobacteria,42RRR@68525|delta/epsilon subdivisions,2WP60@28221|Deltaproteobacteria,2MK3X@213118|Desulfobacterales 28221|Deltaproteobacteria C Flavodoxin domain - - - - - - - - - - - - Flavodoxin_5 k59_115475_2 439235.Dalk_2368 1.53e-21 84.7 COG1592@1|root,COG1592@2|Bacteria 2|Bacteria C Rubrerythrin - - - ko:K19824 - - - - ko00000 - - - FeThRed_B,Rubrerythrin k59_115475_3 1121396.KB893066_gene1588 4.98e-34 122.0 COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MK9C@213118|Desulfobacterales 28221|Deltaproteobacteria P Iron-storage protein ftn - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k59_17823_1 1232410.KI421414_gene2924 8.9e-114 344.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,43RXM@69541|Desulfuromonadales 28221|Deltaproteobacteria S SpoVR like protein spoVR - - ko:K06415 - - - - ko00000 - - - SpoVR k59_206094_1 177439.DP0352 1.25e-92 288.0 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,42MFS@68525|delta/epsilon subdivisions,2X6YF@28221|Deltaproteobacteria,2MMQD@213118|Desulfobacterales 28221|Deltaproteobacteria E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1,cNMP_binding k59_102311_1 1189619.pgond44_03088 3.69e-23 97.4 COG0463@1|root,COG0463@2|Bacteria,4NGYU@976|Bacteroidetes,1HXFJ@117743|Flavobacteriia,4C2IZ@83612|Psychroflexus 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_64034_1 243159.AFE_2412 1.76e-154 463.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,1RNSN@1236|Gammaproteobacteria 1236|Gammaproteobacteria GT COG0574 Phosphoenolpyruvate synthase pyruvate phosphate dikinase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 2.7.9.2 ko:K01007,ko:K21787 ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00374,M00837,M00838 R00199,R11662,R11673 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_148116_1 335543.Sfum_1154 2.4e-67 210.0 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1MVQY@1224|Proteobacteria,42REC@68525|delta/epsilon subdivisions,2WNN1@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,HTH_3 k59_76340_1 153721.MYP_379 4.16e-47 162.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,47Q96@768503|Cytophagia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_17824_1 228410.NE1168 2.03e-105 325.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPI8@28216|Betaproteobacteria,372CD@32003|Nitrosomonadales 28216|Betaproteobacteria I PFAM Prenyltransferase squalene oxidase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_115682_1 1173264.KI913949_gene2968 9.56e-40 147.0 COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1G06G@1117|Cyanobacteria,1H70X@1150|Oscillatoriales 1117|Cyanobacteria H Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit cobL - 2.1.1.132 ko:K00595 ko00860,ko01100,map00860,map01100 - R05149 RC00003,RC01279 ko00000,ko00001,ko01000 - - - MTS,Methyltransf_4,TP_methylase k59_180753_1 234267.Acid_4207 5.2e-14 76.6 COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria 57723|Acidobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_154569_1 713587.THITH_08650 1.01e-65 208.0 COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,1RS8P@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Protein-disulfide isomerase VP2116 - - ko:K07396 - - - - ko00000 - - - DSBA,Thioredoxin_5 k59_76550_1 105559.Nwat_1170 4.09e-51 177.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RYB4@1236|Gammaproteobacteria,1WVUT@135613|Chromatiales 135613|Chromatiales CP PFAM NADH Ubiquinone plastoquinone - - - - - - - - - - - - Proton_antipo_M k59_51142_1 765910.MARPU_13555 3.9e-282 777.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales 135613|Chromatiales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_135424_1 1396858.Q666_10525 2.31e-32 124.0 COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria,466QM@72275|Alteromonadaceae 1236|Gammaproteobacteria U General secretion pathway protein J gspJ GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_206264_1 227377.CBU_1295 2.41e-20 84.7 COG4118@1|root,COG4118@2|Bacteria,1QTA8@1224|Proteobacteria,1SUJ0@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox k59_206264_2 398767.Glov_3572 1.04e-57 181.0 COG1487@1|root,COG1487@2|Bacteria,1N44Q@1224|Proteobacteria,42UNG@68525|delta/epsilon subdivisions,2WRVS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - PIN k59_102471_1 1121405.dsmv_0302 1.91e-74 238.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_180761_1 1027292.HMPREF9372_1664 5.41e-48 169.0 COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes,4HBAA@91061|Bacilli,26EMI@186818|Planococcaceae 91061|Bacilli P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_115693_1 1322246.BN4_10932 2.46e-13 75.5 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482,ko:K10819 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_9 k59_167502_1 1537994.JQFW01000021_gene1148 1.77e-12 62.4 COG4551@1|root,COG4551@2|Bacteria,1N05F@1224|Proteobacteria,1SBIZ@1236|Gammaproteobacteria,46B7E@72275|Alteromonadaceae 1236|Gammaproteobacteria S Phosphotyrosine protein phosphatase - - - - - - - - - - - - - k59_167502_2 1123319.AUBE01000014_gene5411 1.46e-42 155.0 2F8P4@1|root,3411J@2|Bacteria,2IBX6@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_51155_1 589865.DaAHT2_2431 2.24e-82 262.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42RS8@68525|delta/epsilon subdivisions,2X5QK@28221|Deltaproteobacteria,2MPFP@213118|Desulfobacterales 28221|Deltaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_167504_1 579138.Zymop_0966 2.66e-41 152.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,2KEP1@204457|Sphingomonadales 28211|Alphaproteobacteria K ATPase associated with various cellular activities, AAA_5 anfA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_25382_1 1234364.AMSF01000098_gene2680 3.1e-101 310.0 COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,1RYMI@1236|Gammaproteobacteria,1X5QQ@135614|Xanthomonadales 135614|Xanthomonadales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_56776_4 631362.Thi970DRAFT_01068 1.03e-237 665.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWPX@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_83437_1 335543.Sfum_1182 1.18e-07 55.1 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein hdrA - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Pyr_redox_2 k59_83437_2 335543.Sfum_1064 3.62e-62 197.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,42S2E@68525|delta/epsilon subdivisions,2WMT9@28221|Deltaproteobacteria,2MRV6@213462|Syntrophobacterales 28221|Deltaproteobacteria F Phosphoribosyl transferase domain pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_64235_3 1455608.JDTH01000002_gene1028 3.86e-43 159.0 COG0547@1|root,arCOG02012@2157|Archaea,2XU35@28890|Euryarchaeota,23TCP@183963|Halobacteria 183963|Halobacteria E Anthranilate phosphoribosyltransferase trpD2 - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_64235_6 331678.Cphamn1_0620 5.64e-37 143.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_109555_5 159087.Daro_2602 1.78e-97 295.0 COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,2VIVQ@28216|Betaproteobacteria,2KUCY@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_109555_9 1123518.ARWI01000001_gene85 3.49e-15 78.2 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,4606S@72273|Thiotrichales 72273|Thiotrichales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA k59_109557_1 1049564.TevJSym_av00130 9.1e-39 133.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1J6GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein, required for colicin V production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_109557_2 631362.Thi970DRAFT_04963 3.58e-33 125.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales 135613|Chromatiales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_180771_1 1121405.dsmv_2117 5.73e-20 85.9 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42QDS@68525|delta/epsilon subdivisions,2WMQ3@28221|Deltaproteobacteria,2MJQ8@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_135449_1 204669.Acid345_3056 4.29e-46 162.0 COG1972@1|root,COG1972@2|Bacteria,3Y2KI@57723|Acidobacteria,2JIKE@204432|Acidobacteriia 204432|Acidobacteriia F PFAM Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_182472_1 1049564.TevJSym_ar00180 7.63e-170 487.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1J51D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_111135_1 1049564.TevJSym_aw00320 9.03e-131 379.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_33291_1 1121440.AUMA01000003_gene2817 8.37e-59 198.0 COG3829@1|root,COG3829@2|Bacteria,1N1WB@1224|Proteobacteria,42P76@68525|delta/epsilon subdivisions,2WIU6@28221|Deltaproteobacteria,2M9BJ@213115|Desulfovibrionales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_98018_1 2340.JV46_14590 7.77e-114 353.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1J4ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_52764_2 187272.Mlg_1273 3.2e-17 80.5 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,1RRBY@1236|Gammaproteobacteria,1X06W@135613|Chromatiales 135613|Chromatiales S Nucleoside recognition - - - - - - - - - - - - Gate k59_39779_1 76114.p2B15 2.36e-100 322.0 COG4227@1|root,COG4643@1|root,COG4227@2|Bacteria,COG4643@2|Bacteria,1MU8I@1224|Proteobacteria,2VMTV@28216|Betaproteobacteria,2KZ44@206389|Rhodocyclales 206389|Rhodocyclales L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738 k59_26910_1 768671.ThimaDRAFT_1032 2.11e-137 418.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_188920_1 1392838.AWNM01000039_gene830 4.51e-71 223.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,3T390@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_124091_1 96561.Dole_2996 9.72e-42 141.0 COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,42R2R@68525|delta/epsilon subdivisions,2WMSJ@28221|Deltaproteobacteria,2MJRA@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulator, AsnC family - - - - - - - - - - - - HTH_24,HTH_AsnC-type k59_124091_2 933262.AXAM01000055_gene1249 3.97e-50 169.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2MITS@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_72243_1 93220.LV28_13710 1.1e-24 102.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VH24@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF k59_20238_1 471223.GWCH70_2050 4.13e-85 275.0 COG2801@1|root,COG2801@2|Bacteria,1TT3E@1239|Firmicutes,4HCXM@91061|Bacilli,1WFU8@129337|Geobacillus 91061|Bacilli L DDE domain - - - - - - - - - - - - DDE_Tnp_IS240 k59_78889_1 1123277.KB893173_gene1814 6.53e-35 133.0 COG1835@1|root,COG1835@2|Bacteria,4NIVR@976|Bacteroidetes,47UHK@768503|Cytophagia 976|Bacteroidetes I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_143503_1 580332.Slit_1044 4.69e-60 207.0 COG2199@1|root,COG5002@1|root,COG2199@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - CHASE4,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_143503_2 1096930.L284_06440 7.9e-13 65.1 COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria 1224|Proteobacteria K PFAM helix-turn-helix domain protein - - - - - - - - - - - - HTH_3,HTH_31 k59_39780_1 765913.ThidrDRAFT_0306 8.72e-273 765.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_169466_1 1121405.dsmv_3469 6.16e-67 213.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,42TQG@68525|delta/epsilon subdivisions,2WQG8@28221|Deltaproteobacteria,2MNQJ@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Smr protein MutS2 - - - - - - - - - - - - Smr k59_137024_1 1304883.KI912532_gene990 2.02e-38 134.0 COG2073@1|root,COG2073@2|Bacteria,1MWE6@1224|Proteobacteria,2VP0M@28216|Betaproteobacteria,2KUBU@206389|Rhodocyclales 206389|Rhodocyclales H Cobalamin synthesis G N-terminal cbiGa - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_N,CbiG_mid k59_137024_2 1304883.KI912532_gene991 1.55e-65 207.0 COG2243@1|root,COG2243@2|Bacteria,1MV3G@1224|Proteobacteria,2VK3F@28216|Betaproteobacteria,2KVCN@206389|Rhodocyclales 206389|Rhodocyclales H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_117644_1 292.DM42_2303 1.6e-16 81.3 COG0304@1|root,COG0304@2|Bacteria,1NP8M@1224|Proteobacteria,2VJDN@28216|Betaproteobacteria,1K4FF@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - Ketoacyl-synt_2 k59_117644_2 1304275.C41B8_01932 3.26e-13 69.7 COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,1SFAZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I dehydratase - - - - - - - - - - - - - k59_117644_3 913325.N799_06950 9.83e-103 305.0 COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,1RMCB@1236|Gammaproteobacteria,1X4MA@135614|Xanthomonadales 135614|Xanthomonadales IQ Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_117644_4 697282.Mettu_3252 1.58e-31 118.0 COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,1T2CN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glycosyl Transferase - - - - - - - - - - - - Glycos_transf_2 k59_13759_1 1049564.TevJSym_aa01300 9.08e-71 229.0 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1J5VY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N COG3951 Rod binding protein flgJ GO:0003674,GO:0005198 - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_188933_1 1163617.SCD_n02039 2.29e-47 172.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_98029_1 62928.azo2887 1.03e-30 125.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,2KVBE@206389|Rhodocyclales 206389|Rhodocyclales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_150097_1 909663.KI867150_gene357 5.53e-81 261.0 COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_7442_4 1049564.TevJSym_aa00890 1.22e-200 569.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1J6RI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Insulinase (Peptidase family M16) - - 2.7.7.6 ko:K00960,ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_78890_2 1283300.ATXB01000001_gene963 4.08e-21 102.0 COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,1SCA6@1236|Gammaproteobacteria,1XFD4@135618|Methylococcales 135618|Methylococcales N PFAM Flagellar hook-length control protein - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k59_85161_1 1366050.N234_09705 7.03e-104 307.0 COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,2VI8R@28216|Betaproteobacteria,1K1PX@119060|Burkholderiaceae 28216|Betaproteobacteria C Cob(II)yrinic acid a,c-diamide reductase bluB - 1.13.11.79,2.1.1.107 ko:K02303,ko:K04719 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R03194,R09083 RC00003,RC00435,RC00871,RC02413 ko00000,ko00001,ko00002,ko01000 - - - Nitroreductase k59_85161_2 1123354.AUDR01000012_gene1700 3.4e-215 605.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria,1KRQV@119069|Hydrogenophilales 119069|Hydrogenophilales H CobB/CobQ-like glutamine amidotransferase domain - - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,GATase_3 k59_85161_4 1122134.KB893650_gene1040 4.01e-85 256.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1XJ63@135619|Oceanospirillales 135619|Oceanospirillales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_85161_5 1049564.TevJSym_ba00050 4.42e-165 474.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1J4YZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_104578_1 498211.CJA_3399 6.67e-08 53.9 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1FFRG@10|Cellvibrio 1236|Gammaproteobacteria T Bacterial regulatory protein, Fis family prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_104578_2 1049564.TevJSym_av00250 2.6e-95 303.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,1RQYZ@1236|Gammaproteobacteria,1J5CS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Transmembrane exosortase (Exosortase_EpsH) - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_52780_1 335543.Sfum_2139 1.57e-58 191.0 COG1226@1|root,COG1226@2|Bacteria,1MYKU@1224|Proteobacteria,42SR3@68525|delta/epsilon subdivisions,2WP9S@28221|Deltaproteobacteria,2MS72@213462|Syntrophobacterales 28221|Deltaproteobacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - - - - - - - - - - TrkA_N k59_188934_1 1249627.D779_1234 3.14e-114 343.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales 135613|Chromatiales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_143512_1 1245469.S58_42420 5.12e-14 83.6 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,2TU4W@28211|Alphaproteobacteria,3JW62@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_156485_1 1121405.dsmv_3647 1.12e-50 165.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,42R1J@68525|delta/epsilon subdivisions,2WQE8@28221|Deltaproteobacteria,2MKCS@213118|Desulfobacterales 28221|Deltaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_156485_2 933262.AXAM01000079_gene2205 3.4e-31 115.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2MHWH@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_26927_2 1049564.TevJSym_ai00430 4.25e-38 133.0 COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,1S4AS@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_143514_1 1121405.dsmv_3354 1.24e-51 171.0 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,42QXT@68525|delta/epsilon subdivisions,2WN0R@28221|Deltaproteobacteria,2MJ9Y@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_806_1 203122.Sde_0046 9.05e-47 162.0 COG2267@1|root,COG2267@2|Bacteria,1N0W6@1224|Proteobacteria,1S931@1236|Gammaproteobacteria 1236|Gammaproteobacteria I carboxylic ester hydrolase activity - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_169481_1 203275.BFO_0051 9.14e-24 104.0 COG3385@1|root,COG3385@2|Bacteria,4NXT2@976|Bacteroidetes,2FRVS@200643|Bacteroidia,2319R@171551|Porphyromonadaceae 976|Bacteroidetes L hmm pf01609 - - - - - - - - - - - - DDE_Tnp_1_4 k59_52782_1 765913.ThidrDRAFT_2759 7.97e-177 503.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,1RQ8X@1236|Gammaproteobacteria,1WW6F@135613|Chromatiales 135613|Chromatiales C Belongs to the NifD NifK NifE NifN family - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_65821_4 1049564.TevJSym_be00290 2.08e-213 597.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1J4WT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_189087_1 498211.CJA_2081 6.79e-11 66.2 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R59Q@1224|Proteobacteria,1RSPW@1236|Gammaproteobacteria,1FGBM@10|Cellvibrio 1236|Gammaproteobacteria PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_202114_1 502025.Hoch_3702 8.26e-51 181.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_27041_1 1121405.dsmv_2437 6.95e-54 174.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MKKC@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_27041_2 1304885.AUEY01000054_gene164 1.56e-07 51.6 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_143686_1 1121396.KB893088_gene355 4.76e-25 109.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_33459_1 1121405.dsmv_3755 9.23e-26 99.8 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2MJW2@213118|Desulfobacterales 28221|Deltaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_59430_1 1379698.RBG1_1C00001G1457 1.28e-17 83.6 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_98148_1 396588.Tgr7_2382 1.68e-94 286.0 COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria,1RXE1@1236|Gammaproteobacteria,1WZVQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source - - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_85282_2 1049564.TevJSym_br00030 2.98e-07 56.6 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,Fer4_8,RnfC_N,SLBB k59_195303_1 1161401.ASJA01000016_gene1378 7.04e-16 75.9 COG0225@1|root,COG0225@2|Bacteria,1R5GQ@1224|Proteobacteria,2VGNN@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA_2 - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_195303_2 395493.BegalDRAFT_3323 1.15e-21 98.6 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNI8@1236|Gammaproteobacteria,463US@72273|Thiotrichales 72273|Thiotrichales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_124258_1 56780.SYN_00324 1.27e-65 211.0 COG1633@1|root,COG1633@2|Bacteria 2|Bacteria S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin,POR,Rubrerythrin k59_202119_1 1049564.TevJSym_by00080 2.2e-62 200.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1J4NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_202119_2 1385517.N800_02635 1.07e-20 91.3 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_124262_1 356829.BITS_1716 0.000441 44.7 COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4D0RN@85004|Bifidobacteriales 201174|Actinobacteria T Inner membrane component of T3SS, cytoplasmic domain fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - - - - - - - - - - FHA,Yop-YscD_cpl k59_130808_2 1049564.TevJSym_ad00090 9.92e-22 86.3 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1J7AC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_130808_3 301.JNHE01000027_gene3012 3.47e-16 74.3 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1YDEK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_7615_2 398767.Glov_3675 5.04e-31 129.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2WKBQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria P TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_143705_1 335283.Neut_1444 1.14e-16 84.7 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VUP7@28216|Betaproteobacteria,374K3@32003|Nitrosomonadales 28216|Betaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.7.65 ko:K13069,ko:K21085 ko02026,map02026 - R08057 - ko00000,ko00001,ko01000 - - - CHASE7,GGDEF,HAMP k59_104704_1 1049564.TevJSym_ad01540 9.79e-13 66.6 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1J5PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q E COG1126 ABC-type polar amino acid transport system, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_104704_2 118163.Ple7327_1176 0.000158 52.0 COG1463@1|root,COG1463@2|Bacteria,1G1A7@1117|Cyanobacteria,3VHYB@52604|Pleurocapsales 1117|Cyanobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component ycf22 - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_104704_3 1049564.TevJSym_ad01560 9.48e-31 118.0 COG3009@1|root,COG3009@2|Bacteria,1PDJY@1224|Proteobacteria,1SFZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_901_1 1454004.AW11_03317 4.29e-114 352.0 COG1404@1|root,COG1404@2|Bacteria,1ND93@1224|Proteobacteria,2VKTR@28216|Betaproteobacteria 28216|Betaproteobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_195308_1 396588.Tgr7_0941 1.31e-78 256.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_33471_1 1049564.TevJSym_az00070 1.28e-183 537.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family phsA - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_33471_2 1049564.TevJSym_az00080 1.2e-08 53.9 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1RPUU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Tetrathionate reductase, subunit B ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_27059_2 629265.PMA4326_12553 7.23e-08 52.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1Z6SZ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_182689_4 243233.MCA2451 5.28e-55 181.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1XEJ2@135618|Methylococcales 135618|Methylococcales M epimerase dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_46381_1 335543.Sfum_1778 4.94e-43 147.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2MQCC@213462|Syntrophobacterales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_52936_1 653733.Selin_1858 4.56e-75 252.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria 2|Bacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_119490_1 1449076.JOOE01000002_gene759 4.25e-17 80.9 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K1V7@204457|Sphingomonadales 204457|Sphingomonadales C CoA binding domain ferA - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_119490_2 909613.UO65_2349 1.52e-60 198.0 COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4E0X0@85010|Pseudonocardiales 201174|Actinobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_80473_1 1122609.AUGT01000020_gene1015 1.01e-14 80.1 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,2HE4H@201174|Actinobacteria,4DTK0@85009|Propionibacteriales 201174|Actinobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_80473_3 1244869.H261_12381 4.34e-39 140.0 COG0407@1|root,COG0407@2|Bacteria,1R9IN@1224|Proteobacteria 1224|Proteobacteria H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_9041_2 631362.Thi970DRAFT_04553 1.41e-87 262.0 296YQ@1|root,2ZU7A@2|Bacteria,1RDAE@1224|Proteobacteria,1S6SJ@1236|Gammaproteobacteria,1X06C@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_9041_3 395495.Lcho_1136 6.96e-52 178.0 COG3005@1|root,COG3005@2|Bacteria,1QZ6I@1224|Proteobacteria,2VPS8@28216|Betaproteobacteria 28216|Betaproteobacteria C Class III cytochrome C family - - - - - - - - - - - - Cytochrom_CIII k59_9041_5 717231.Flexsi_1638 1.55e-50 163.0 COG3152@1|root,COG3152@2|Bacteria,2GGNJ@200930|Deferribacteres 200930|Deferribacteres S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_67237_1 329726.AM1_6260 4.96e-99 305.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3YK@1117|Cyanobacteria 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_23 k59_164426_1 335543.Sfum_1615 3.86e-86 261.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MRC6@213462|Syntrophobacterales 28221|Deltaproteobacteria S AAA domain (Cdc48 subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_22157_2 334545.CCMG01000010_gene795 2.68e-12 63.9 COG2026@1|root,COG2026@2|Bacteria 2|Bacteria DJ nuclease activity - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_177682_1 1278971.AOGF01000045_gene639 2.52e-25 105.0 COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,1SZQV@1236|Gammaproteobacteria,1YAXA@135625|Pasteurellales 1236|Gammaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595 k59_196576_1 879212.DespoDRAFT_03493 2.3e-20 93.6 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WM56@28221|Deltaproteobacteria,2MHKW@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,Response_reg k59_190547_2 1278309.KB907099_gene2739 1.73e-47 155.0 COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S6BG@1236|Gammaproteobacteria,1XMEE@135619|Oceanospirillales 135619|Oceanospirillales S Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - RelE k59_190547_3 1453501.JELR01000001_gene3002 5e-47 152.0 COG2944@1|root,COG2944@2|Bacteria,1RK75@1224|Proteobacteria,1S96V@1236|Gammaproteobacteria,468X4@72275|Alteromonadaceae 1236|Gammaproteobacteria K Helix-turn-helix domain - - - ko:K07726 - - - - ko00000,ko03000 - - - MqsA_antitoxin k59_47821_1 880072.Desac_1210 3.84e-68 221.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2MQ9R@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_67239_1 768671.ThimaDRAFT_2786 3.17e-21 90.9 28P4X@1|root,2ZC02@2|Bacteria,1RB0B@1224|Proteobacteria,1S2S5@1236|Gammaproteobacteria,1WY6M@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - DUF2764 k59_67239_2 1049564.TevJSym_aa02450 9.37e-187 537.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_28430_1 335543.Sfum_1723 2.43e-97 305.0 COG0070@1|root,COG0493@1|root,COG1145@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,2MR5X@213462|Syntrophobacterales 28221|Deltaproteobacteria C GXGXG motif - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF k59_190549_1 395495.Lcho_3778 4.19e-90 281.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1KK3V@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Belongs to the 5'-nucleotidase family soxB - 3.1.3.5,3.6.1.45 ko:K11751,ko:K17224 ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120 M00595 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151 RC00017,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C k59_99402_1 526222.Desal_3560 3.55e-135 389.0 COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,42NEK@68525|delta/epsilon subdivisions,2WJPT@28221|Deltaproteobacteria,2M87E@213115|Desulfovibrionales 28221|Deltaproteobacteria S Dienelactone hydrolase family - - - ko:K06889 - - - - ko00000 - - - DLH,Peptidase_S15 k59_73515_1 394221.Mmar10_2651 8.14e-05 43.9 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,2U7ND@28211|Alphaproteobacteria,43XV6@69657|Hyphomonadaceae 28211|Alphaproteobacteria K COG1846 Transcriptional regulators - - - - - - - - - - - - MarR k59_73515_2 1536773.R70331_26890 2.37e-77 238.0 COG1335@1|root,COG1335@2|Bacteria,1V641@1239|Firmicutes,4HRMB@91061|Bacilli,2714I@186822|Paenibacillaceae 91061|Bacilli Q isochorismatase - - - - - - - - - - - - Isochorismatase k59_73515_3 395494.Galf_0110 9.44e-83 262.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,44VGN@713636|Nitrosomonadales 28216|Betaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein rnfF - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_86713_1 1049564.TevJSym_ab01210 4.26e-102 321.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_86713_2 596151.DesfrDRAFT_2958 5.51e-15 79.3 COG2197@1|root,COG2197@2|Bacteria,1PTWI@1224|Proteobacteria,436RK@68525|delta/epsilon subdivisions,2X1EM@28221|Deltaproteobacteria,2MEW7@213115|Desulfovibrionales 28221|Deltaproteobacteria K Autoinducer binding domain - - - - - - - - - - - - Autoind_bind,GerE k59_86713_3 857087.Metme_1124 2.85e-186 601.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_86713_4 1266909.AUAG01000009_gene629 1.18e-62 209.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1S43R@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_86713_5 1049564.TevJSym_ad00970 0.0 1016.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1J4JP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_86713_7 768671.ThimaDRAFT_4007 1.17e-53 174.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1WY2K@135613|Chromatiales 135613|Chromatiales S TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR - - - - - - - - - - - - PHB_acc,PHB_acc_N k59_80476_1 519989.ECTPHS_06737 8.21e-168 486.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1WX7Y@135613|Chromatiales 135613|Chromatiales HJ Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - - - - - - - - - - ATP-grasp_3,RLAN,RimK k59_80476_2 1249627.D779_3424 5.82e-47 162.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales 135613|Chromatiales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_47822_1 335543.Sfum_1375 5.97e-123 362.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_47822_2 161156.JQKW01000013_gene129 1.32e-51 167.0 COG0698@1|root,COG0698@2|Bacteria,2GH7Z@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Ribose/Galactose Isomerase - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_60885_2 1049564.TevJSym_bc00130 4.39e-190 532.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360 ACP_syn_III,ACP_syn_III_C k59_60885_3 1049564.TevJSym_bc00120 5.33e-181 510.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1J57J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:0090407,GO:1901576 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcDH1_1363.EcDH1_2557,iSFxv_1172.SFxv_1246,iY75_1357.Y75_RS05695 FA_synthesis k59_60885_4 1415779.JOMH01000001_gene1696 2.95e-14 66.2 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1X8C1@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_119507_1 56780.SYN_02026 4.49e-44 163.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MQ85@213462|Syntrophobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_184397_1 394.NGR_a03040 8.53e-72 218.0 COG1487@1|root,COG1487@2|Bacteria,1MZQC@1224|Proteobacteria,2U73E@28211|Alphaproteobacteria,4BE5H@82115|Rhizobiaceae 28211|Alphaproteobacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase vapC - - ko:K07062 - - - - ko00000,ko01000,ko02048 - - - PIN k59_184397_2 1123366.TH3_17454 1.87e-43 142.0 COG4691@1|root,COG4691@2|Bacteria,1N8BI@1224|Proteobacteria,2UBTT@28211|Alphaproteobacteria,2JTXE@204441|Rhodospirillales 204441|Rhodospirillales S Plasmid stability protein - - - ko:K21495 - - - - ko00000,ko02048 - - - Arc k59_93584_2 13035.Dacsa_0642 2.13e-07 55.8 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - HNH,HNH_5,RRXRR k59_9058_1 439235.Dalk_2279 4.26e-125 388.0 COG1033@1|root,COG4191@1|root,COG1033@2|Bacteria,COG4191@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - GGDEF,LolA_like,MMPL,cNMP_binding k59_164439_1 1265505.ATUG01000001_gene4444 4.16e-52 187.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,42W78@68525|delta/epsilon subdivisions,2WRWC@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3' - - - ko:K03556 - - - - ko00000,ko03000 - - - BTAD,GerE k59_138347_1 497964.CfE428DRAFT_0179 1.84e-66 219.0 COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia 74201|Verrucomicrobia L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_171287_3 1395571.TMS3_0120335 4.68e-41 164.0 COG1475@1|root,COG1475@2|Bacteria,1P9JB@1224|Proteobacteria,1RS4J@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - Arg_repressor,ParBc k59_158015_1 1307759.JOMJ01000003_gene1692 1.48e-75 243.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBF@1224|Proteobacteria,42RAR@68525|delta/epsilon subdivisions,2WN52@28221|Deltaproteobacteria,2MAC7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - GAF,GAF_2,SpoIIE k59_47825_2 313612.L8106_02312 1.47e-13 67.8 COG2929@1|root,COG2929@2|Bacteria,1G8FA@1117|Cyanobacteria,1HHKT@1150|Oscillatoriales 1117|Cyanobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_47825_3 1255043.TVNIR_2870 2.01e-72 231.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1WXT0@135613|Chromatiales 135613|Chromatiales S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_203446_1 1232410.KI421416_gene2687 1.04e-87 261.0 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42PGG@68525|delta/epsilon subdivisions,2WIM1@28221|Deltaproteobacteria,43S3U@69541|Desulfuromonadales 28221|Deltaproteobacteria H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_184398_1 118168.MC7420_5670 1.69e-58 196.0 COG3875@1|root,COG3875@2|Bacteria,1G82E@1117|Cyanobacteria,1HDBH@1150|Oscillatoriales 1117|Cyanobacteria S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 k59_184398_2 644282.Deba_0869 2.24e-55 186.0 COG1149@1|root,COG1149@2|Bacteria,1QWNA@1224|Proteobacteria,43BT8@68525|delta/epsilon subdivisions,2X73X@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_119514_1 1049564.TevJSym_aa02310 1.88e-230 641.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1J4D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_145307_1 1049564.TevJSym_ah00850 2.73e-103 328.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_86724_2 1304885.AUEY01000009_gene1930 2.98e-43 146.0 28NQ4@1|root,2ZBPU@2|Bacteria,1RCN1@1224|Proteobacteria,42QPC@68525|delta/epsilon subdivisions,2WMVS@28221|Deltaproteobacteria,2MJR9@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_99419_1 765177.Desmu_0503 6.05e-19 86.7 COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota 28889|Crenarchaeota G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_177707_1 1278307.KB906974_gene1806 3.95e-84 289.0 COG0642@1|root,COG0834@1|root,COG4251@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QIRM@267894|Psychromonadaceae 1236|Gammaproteobacteria T ATP-binding region, ATPase domain protein domain protein - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - CHASE,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_41774_1 933262.AXAM01000081_gene2257 2.74e-152 446.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MIQB@213118|Desulfobacterales 28221|Deltaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_47826_1 159087.Daro_4173 1.9e-95 301.0 COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,2KUKB@206389|Rhodocyclales 206389|Rhodocyclales IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_9066_1 1121405.dsmv_0343 6.63e-81 254.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MI2A@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_3528 Seryl_tRNA_N,tRNA-synt_2b k59_60903_1 1499967.BAYZ01000060_gene5986 1.01e-42 154.0 COG1243@1|root,COG1243@2|Bacteria 2|Bacteria BK radical SAM domain protein - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Fer4_14,Radical_SAM,Radical_SAM_C k59_28444_1 195253.Syn6312_1033 8.03e-92 271.0 arCOG06889@1|root,32RJ7@2|Bacteria 2|Bacteria S PFAM MTH538 TIR-like domain - - - - - - - - - - - - DUF1863 k59_126169_1 195250.CM001776_gene952 8.06e-104 310.0 COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus 1117|Cyanobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_138471_1 1301098.PKB_4797 5.83e-141 410.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB k59_138471_3 768671.ThimaDRAFT_4232 3.55e-132 387.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1WX1N@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_196723_1 1002340.AFCF01000027_gene1270 2.77e-12 72.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,34DWS@302485|Phaeobacter 28211|Alphaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). mcpP - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,NIT,PAS_4,PAS_8,PAS_9,dCache_1 k59_126171_1 880072.Desac_1024 3.19e-63 206.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria,2MQRV@213462|Syntrophobacterales 28221|Deltaproteobacteria EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_41991_1 1121924.ATWH01000003_gene1639 6.04e-36 134.0 COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,4FNT9@85023|Microbacteriaceae 201174|Actinobacteria S KR domain - - - ko:K07124 - - - - ko00000 - - - adh_short k59_132598_1 1049564.TevJSym_br00020 2e-194 587.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_47984_1 706587.Desti_4197 2.43e-159 460.0 COG1304@1|root,COG1304@2|Bacteria,1P72V@1224|Proteobacteria,42NSD@68525|delta/epsilon subdivisions,2WJRW@28221|Deltaproteobacteria,2MR3Y@213462|Syntrophobacterales 28221|Deltaproteobacteria C Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_184494_4 314278.NB231_12134 2.78e-46 167.0 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,1S1M0@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_22295_1 656519.Halsa_1804 1.42e-16 83.6 COG1462@1|root,COG1462@2|Bacteria 2|Bacteria M curli production assembly transport component CsgG - - - ko:K06214,ko:K13586 ko04112,map04112 - - - ko00000,ko00001,ko02044 - - - CsgG k59_192301_1 1437824.BN940_15161 2.27e-121 379.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,3T1IE@506|Alcaligenaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_49823_1 1121413.JMKT01000012_gene502 4.95e-171 485.0 COG1509@1|root,COG1509@2|Bacteria,1P6YH@1224|Proteobacteria,42MQW@68525|delta/epsilon subdivisions,2WJUR@28221|Deltaproteobacteria,2MCV8@213115|Desulfovibrionales 28221|Deltaproteobacteria E TIGRFAM lysine 2,3-aminomutase YodO family protein - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - LAM_C k59_160126_1 272560.BPSS1632 0.0 1069.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae 28216|Betaproteobacteria Q amino acid adenylation domain protein - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase k59_128348_1 1453501.JELR01000001_gene2432 9.64e-112 339.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,464CA@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_101213_1 714943.Mucpa_0355 3.37e-18 81.3 2CFGC@1|root,33FFI@2|Bacteria,4NZ32@976|Bacteroidetes 976|Bacteroidetes S sptr putative - - - - - - - - - - - - - k59_44378_1 472759.Nhal_2225 2.67e-121 360.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1X07Y@135613|Chromatiales 135613|Chromatiales E TIGRFAM amidase, hydantoinase carbamoylase - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_16827_1 642492.Clole_3793 1.8e-45 156.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_16827_2 713586.KB900536_gene2498 4.61e-25 102.0 COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,1RYY5@1236|Gammaproteobacteria,1WW1F@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_134196_1 1049564.TevJSym_ak00150 1.85e-142 434.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_75299_1 1255043.TVNIR_2442 7.08e-116 336.0 COG0338@1|root,COG0338@2|Bacteria,1QDNB@1224|Proteobacteria,1RXZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase - - - - - - - - - - - - MethyltransfD12 k59_37127_2 768671.ThimaDRAFT_1693 1.79e-125 370.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1WXRH@135613|Chromatiales 135613|Chromatiales S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_49827_2 1049564.TevJSym_ab01910 1.14e-111 340.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ygaD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_44383_1 933262.AXAM01000039_gene1156 8.38e-90 276.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II secretion system pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_69597_1 335543.Sfum_3952 2.46e-24 98.2 COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MRHW@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM CBS domain - - - ko:K04767 - - - - ko00000 - - - CBS k59_69597_2 933262.AXAM01000060_gene2881 6.46e-11 59.7 COG2204@1|root,COG2204@2|Bacteria,1R1JI@1224|Proteobacteria,43D9S@68525|delta/epsilon subdivisions,2X8GC@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_140232_2 1049564.TevJSym_bb00350 1.71e-54 173.0 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1JBM2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like k59_140232_3 446471.Xcel_0121 0.00098 48.5 COG0596@1|root,COG0596@2|Bacteria,2GKT5@201174|Actinobacteria,4F4DP@85017|Promicromonosporaceae 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_140232_6 748280.NH8B_3251 7.67e-106 326.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,2KPYG@206351|Neisseriales 206351|Neisseriales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_37128_1 1121396.KB893101_gene563 1.34e-25 100.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,42SHZ@68525|delta/epsilon subdivisions,2WPFZ@28221|Deltaproteobacteria,2MK53@213118|Desulfobacterales 28221|Deltaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_24100_1 90813.JQMT01000001_gene764 2.22e-93 288.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,45ZW1@72273|Thiotrichales 72273|Thiotrichales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_30300_1 909663.KI867150_gene2034 9.11e-73 228.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2MQFE@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_172637_1 159087.Daro_1690 1.25e-115 342.0 COG1903@1|root,COG1903@2|Bacteria,1MXU3@1224|Proteobacteria,2VITG@28216|Betaproteobacteria,2KUJC@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_179599_1 1415780.JPOG01000001_gene1953 7.5e-44 164.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales 1236|Gammaproteobacteria T Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_179599_2 1318628.MARLIPOL_06959 2.6e-90 295.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,4658X@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_179599_3 566466.NOR53_1919 1.71e-103 328.0 COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria,1J9WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - AMIN k59_82356_1 1121405.dsmv_3459 5.72e-64 204.0 COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,42PMZ@68525|delta/epsilon subdivisions,2WMF7@28221|Deltaproteobacteria,2MJ13@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ApbE family - - - ko:K09740 - - - - ko00000 - - - - k59_160134_2 1524467.IV04_15480 8.43e-142 418.0 COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria,404FK@613|Serratia 1236|Gammaproteobacteria E GMC oxidoreductase - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_30301_1 642492.Clole_1552 1.8e-55 183.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_30301_2 1232437.KL661960_gene3068 7.1e-34 124.0 COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,42TPF@68525|delta/epsilon subdivisions,2WR03@28221|Deltaproteobacteria,2MJRQ@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_55783_1 1049564.TevJSym_ar00020 4.12e-145 417.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_140251_1 1049564.TevJSym_af00910 2.33e-30 115.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_160139_1 335543.Sfum_3063 6.47e-69 223.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MQ40@213462|Syntrophobacterales 28221|Deltaproteobacteria M PDZ domain (Also known as DHR or GLGF) ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_63049_2 1123242.JH636434_gene4517 3.43e-30 109.0 COG3464@1|root,COG3464@2|Bacteria,2J3VD@203682|Planctomycetes 203682|Planctomycetes L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3 k59_63049_4 396588.Tgr7_1770 2.7e-45 167.0 2E0WK@1|root,32WDJ@2|Bacteria,1NPZY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_82364_1 335543.Sfum_1371 3.3e-42 148.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_82364_2 1123371.ATXH01000038_gene1356 3.73e-90 275.0 COG0332@1|root,COG0332@2|Bacteria,2GHJ2@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_172649_1 395964.KE386496_gene2524 7.28e-100 304.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3ND04@45404|Beijerinckiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_128379_1 1173027.Mic7113_1202 7.98e-70 230.0 COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,1H8T3@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Prolyl oligopeptidase family dap2 - - - - - - - - - - - PD40,Peptidase_S9 k59_108288_1 1249627.D779_3677 3.67e-118 351.0 COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria,1WWDM@135613|Chromatiales 135613|Chromatiales CP PFAM NADH Ubiquinone plastoquinone - - - ko:K12141 - - - - ko00000,ko01000 - - - Proton_antipo_M k59_192334_1 1382306.JNIM01000001_gene2590 1.12e-56 185.0 COG0353@1|root,COG0353@2|Bacteria,2G6CT@200795|Chloroflexi 200795|Chloroflexi L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_198383_2 1123400.KB904764_gene2454 1.15e-42 149.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RY7B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M TIGRFAM RHS repeat-associated core domain wapA - - - - - - - - - - - NHL,RHS_repeat k59_134217_1 768671.ThimaDRAFT_2942 9e-122 367.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1WXU8@135613|Chromatiales 135613|Chromatiales C oxidoreductase, alpha subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N,Transketolase_C k59_140266_1 1298858.AUEL01000001_gene4623 3.72e-30 124.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity opsX GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02841,ko:K02849,ko:K12982 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_172650_1 335543.Sfum_3724 1.97e-94 297.0 COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM DAHP synthetase I KDSA - - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,DAHP_synth_1,PDT k59_114556_1 1049564.TevJSym_ac01920 9.6e-56 186.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1J4C1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_69632_1 105559.Nwat_2012 1.89e-77 237.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1WXEP@135613|Chromatiales 135613|Chromatiales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_69632_2 396588.Tgr7_1253 1.74e-21 92.8 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_166411_2 880072.Desac_0314 5.15e-47 159.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - CdhD,MTHFR k59_24313_1 1049564.TevJSym_ar00620 7.38e-156 442.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_24313_2 1049564.TevJSym_ar00610 5.01e-15 71.6 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,1S85V@1236|Gammaproteobacteria,1JAMH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_128582_2 1415779.JOMH01000001_gene879 4.78e-11 64.3 COG2885@1|root,COG2885@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family mopB - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_140500_1 177437.HRM2_15050 1.74e-24 107.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,42Z0I@68525|delta/epsilon subdivisions,2WUFE@28221|Deltaproteobacteria,2MN2T@213118|Desulfobacterales 28221|Deltaproteobacteria P heavy metal translocating P-type ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_63265_1 1121405.dsmv_3039 2.53e-92 284.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2MHNC@213118|Desulfobacterales 28221|Deltaproteobacteria J 3'-5' exonuclease rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_147273_1 1288826.MSNKSG1_16711 3.01e-53 179.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,465MY@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0281 Malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_44647_1 933262.AXAM01000015_gene66 9.06e-103 309.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2MI8E@213118|Desulfobacterales 28221|Deltaproteobacteria J Protein of unknown function (DUF933) - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_50077_1 1121405.dsmv_1256 8.22e-63 202.0 COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria,2MIJG@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS_4,PAS_9 k59_11294_1 1049564.TevJSym_ag00400 8.83e-111 326.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_101464_2 1123033.ARNF01000014_gene1493 1.13e-46 191.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3NJV2@468|Moraxellaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_96261_1 933262.AXAM01000053_gene2714 7.41e-29 112.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales 28221|Deltaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261 ATP-grasp_2,Ligase_CoA k59_122096_1 1232410.KI421420_gene3215 6.36e-122 359.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,42QBB@68525|delta/epsilon subdivisions,2WKEZ@28221|Deltaproteobacteria,43T67@69541|Desulfuromonadales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_75548_1 1479237.JMLY01000001_gene1375 4.96e-56 182.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_75548_2 546268.NEISUBOT_03712 2.03e-52 172.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KPIK@206351|Neisseriales 206351|Neisseriales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_153601_1 396588.Tgr7_2114 3.12e-81 266.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_101472_1 1121033.AUCF01000001_gene1937 5.5e-05 44.3 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,2JR9D@204441|Rhodospirillales 204441|Rhodospirillales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_207241_1 1265505.ATUG01000002_gene1153 8.44e-136 399.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2MJ61@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3395 Aldedh k59_19422_1 439235.Dalk_3445 1.59e-49 172.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2MJW6@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_174858_1 1499967.BAYZ01000019_gene6299 6.01e-67 208.0 COG1633@1|root,COG1633@2|Bacteria 2|Bacteria S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - Rubrerythrin k59_207243_1 1095769.CAHF01000011_gene2313 2.18e-26 114.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,4727X@75682|Oxalobacteraceae 28216|Betaproteobacteria N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_207243_2 323261.Noc_2366 5.95e-10 58.5 COG1334@1|root,COG1334@2|Bacteria,1NH9T@1224|Proteobacteria,1SH7I@1236|Gammaproteobacteria,1WZAY@135613|Chromatiales 135613|Chromatiales N PFAM Flagellar protein FlaG protein - - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG k59_103668_1 96561.Dole_2441 1.71e-09 55.5 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria 28221|Deltaproteobacteria U TIGRFAM preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_103668_2 118005.AWNK01000010_gene361 2.04e-09 61.2 COG0342@1|root,COG0342@2|Bacteria 2|Bacteria U P-P-bond-hydrolysis-driven protein transmembrane transporter activity secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_77753_2 309799.DICTH_0773 1.27e-12 69.7 COG1384@1|root,COG1384@2|Bacteria 2|Bacteria J tRNA binding lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_6179_1 1049564.TevJSym_bb00150 4.27e-72 223.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1J61K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3166 Tfp pilus assembly protein PilN pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_6179_2 1049564.TevJSym_bb00160 6.2e-74 226.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_77758_1 1304885.AUEY01000002_gene339 3.82e-13 73.9 COG0484@1|root,COG0484@2|Bacteria,1QXUZ@1224|Proteobacteria,43C7N@68525|delta/epsilon subdivisions,2X7HY@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 k59_174880_1 1049564.TevJSym_bc00080 3.94e-146 431.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1J4MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CI COG5016 Pyruvate oxaloacetate carboxyltransferase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_58052_1 243924.LT42_01135 0.000252 40.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding rsmE - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_58052_2 177437.HRM2_36950 7.46e-23 102.0 COG1344@1|root,COG1344@2|Bacteria,1N1QF@1224|Proteobacteria,42TTV@68525|delta/epsilon subdivisions,2WRHH@28221|Deltaproteobacteria,2MIYN@213118|Desulfobacterales 28221|Deltaproteobacteria N Bacterial flagellin N-terminal helical region - - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_207267_1 857087.Metme_3215 1.95e-108 318.0 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RQJ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase k59_207267_2 1120966.AUBU01000012_gene52 6.21e-15 74.3 COG0624@1|root,COG0624@2|Bacteria,4NJEK@976|Bacteroidetes,47N41@768503|Cytophagia 976|Bacteroidetes E Peptidase family M20/M25/M40 - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_200741_1 395963.Bind_3641 7.09e-29 117.0 COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria,3NA76@45404|Beijerinckiaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 pldB - 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_200741_2 319795.Dgeo_0005 4.56e-29 117.0 COG0469@1|root,COG0469@2|Bacteria,1WJAC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Belongs to the pyruvate kinase family pykF - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_58054_1 56780.SYN_01984 3.26e-51 169.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MQHN@213462|Syntrophobacterales 28221|Deltaproteobacteria F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_58054_2 1167006.UWK_02894 1.03e-49 166.0 COG1014@1|root,COG1014@2|Bacteria,1N53C@1224|Proteobacteria,42S8J@68525|delta/epsilon subdivisions,2WQ37@28221|Deltaproteobacteria,2MPU7@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_200749_1 1121405.dsmv_3712 2.82e-90 283.0 28I62@1|root,2Z896@2|Bacteria,1MWB8@1224|Proteobacteria,42P7E@68525|delta/epsilon subdivisions,2WKM1@28221|Deltaproteobacteria,2MIBX@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_77776_1 1449126.JQKL01000008_gene293 1.01e-78 251.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,267RV@186813|unclassified Clostridiales 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_174900_1 768671.ThimaDRAFT_2328 4.01e-190 559.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_207276_4 1174528.JH992892_gene6539 7.39e-28 112.0 COG4974@1|root,COG4974@2|Bacteria,1G67I@1117|Cyanobacteria 1117|Cyanobacteria L Phage integrase family - - - ko:K07358 - - - - ko00000 - - - Phage_integrase k59_58079_1 635013.TherJR_0480 3.68e-34 134.0 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,2637H@186807|Peptococcaceae 186801|Clostridia L PFAM Integrase catalytic - - - - - - - - - - - - HTH_28,Mu-transpos_C,rve k59_174913_1 1279017.AQYJ01000027_gene1550 5.73e-66 226.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,1RPQ2@1236|Gammaproteobacteria,464BZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria icmF - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N k59_6247_1 416591.Tlet_0800 4.01e-25 102.0 COG0559@1|root,COG0559@2|Bacteria,2GC1K@200918|Thermotogae 200918|Thermotogae E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_200780_2 1049564.TevJSym_av00230 3.47e-53 172.0 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,1S35N@1236|Gammaproteobacteria,1JBY8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Polysaccharide biosynthesis/export protein wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_78216_1 335543.Sfum_1228 9.91e-127 390.0 COG0532@1|root,COG3266@1|root,COG0532@2|Bacteria,COG3266@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MQ8J@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_136464_1 1304885.AUEY01000001_gene3214 4.22e-106 314.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2WJY8@28221|Deltaproteobacteria,2MIM2@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_91086_2 713587.THITH_04365 4.67e-29 110.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1WVYN@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_26282_1 1121923.GPUN_1416 8.73e-13 67.4 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,46498@72275|Alteromonadaceae 1236|Gammaproteobacteria E Methionine aminopeptidase map GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_65100_1 933262.AXAM01000046_gene127 4.83e-61 198.0 2E769@1|root,331Q7@2|Bacteria,1NEM5@1224|Proteobacteria,42WHJ@68525|delta/epsilon subdivisions,2WS1T@28221|Deltaproteobacteria,2MM54@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_58715_1 1055815.AYYA01000046_gene1934 0.000133 49.7 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,3NN5N@468|Moraxellaceae 1236|Gammaproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_110513_1 933262.AXAM01000018_gene1005 7.64e-64 211.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_32700_2 626887.J057_18415 4.32e-73 229.0 COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,1RPCX@1236|Gammaproteobacteria,466V7@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterised protein family UPF0066 yaeB GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0089715,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 - - - - - - - - - - UPF0066 k59_103992_1 1121422.AUMW01000010_gene1058 2.71e-07 48.5 2EG8N@1|root,33A0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_52158_1 1049564.TevJSym_aq00560 5.87e-243 684.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_123487_1 335543.Sfum_0942 1.16e-10 67.4 COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K02482,ko:K10819 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9 k59_45664_1 1121438.JNJA01000001_gene2528 1.53e-79 254.0 COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2WKZ8@28221|Deltaproteobacteria,2MGZY@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - 2.4.1.212 ko:K00752,ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.10,4.D.1.1.2,4.D.1.1.3,4.D.1.1.4,4.D.1.1.5 GT2 - Glyco_tranf_2_3,Glycos_transf_2 k59_97558_1 401053.AciPR4_3754 6.07e-28 115.0 COG0476@1|root,COG0476@2|Bacteria,3Y6YI@57723|Acidobacteria,2JKFS@204432|Acidobacteriia 204432|Acidobacteriia H ThiF family - - - - - - - - - - - - ThiF k59_130002_1 1121035.AUCH01000035_gene1722 1.22e-29 127.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria,2KXCF@206389|Rhodocyclales 206389|Rhodocyclales M RHS Repeat - - - - - - - - - - - - RHS_repeat k59_201334_1 1121405.dsmv_0078 3.44e-110 335.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales 28221|Deltaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_6839_1 667014.Thein_0308 2.68e-56 193.0 COG0457@1|root,COG1032@1|root,COG0457@2|Bacteria,COG1032@2|Bacteria,2GI0E@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_32704_1 1232437.KL661966_gene3170 0.000188 45.8 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,42M22@68525|delta/epsilon subdivisions,2WM8F@28221|Deltaproteobacteria,2MPV2@213118|Desulfobacterales 28221|Deltaproteobacteria NT Cache domain mcp64H-1 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_4,dCache_1 k59_155892_1 258533.BN977_05641 4.8e-18 90.1 COG0661@1|root,COG0661@2|Bacteria,2GN97@201174|Actinobacteria,236HC@1762|Mycobacteriaceae 201174|Actinobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_188316_1 765912.Thimo_3206 1.58e-52 180.0 COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria,1WWDM@135613|Chromatiales 135613|Chromatiales CP PFAM NADH Ubiquinone plastoquinone - - - ko:K12141 - - - - ko00000,ko01000 - - - Proton_antipo_M k59_65115_1 1499967.BAYZ01000190_gene3817 2.58e-56 189.0 COG1249@1|root,COG1249@2|Bacteria 2|Bacteria C cell redox homeostasis merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_65115_2 596151.DesfrDRAFT_1155 3.32e-18 83.2 COG1957@1|root,COG1957@2|Bacteria,1QYX6@1224|Proteobacteria,43D4Z@68525|delta/epsilon subdivisions,2X8BM@28221|Deltaproteobacteria,2MHFV@213115|Desulfovibrionales 28221|Deltaproteobacteria F Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_32707_1 56780.SYN_03044 5.22e-39 141.0 COG4254@1|root,COG4254@2|Bacteria,1QVB5@1224|Proteobacteria,42XP1@68525|delta/epsilon subdivisions,2X71D@28221|Deltaproteobacteria 28221|Deltaproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_181813_4 90814.KL370891_gene521 2.61e-52 165.0 COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,1S99Z@1236|Gammaproteobacteria,4617I@72273|Thiotrichales 72273|Thiotrichales S TIGRFAM toxin-antitoxin system, toxin component, Txe YoeB family - - - ko:K19158 - - - - ko00000,ko01000,ko02048 - - - YoeB_toxin k59_181813_5 1385935.N836_23180 2.05e-36 124.0 COG2161@1|root,COG2161@2|Bacteria,1G8D2@1117|Cyanobacteria,1HCF6@1150|Oscillatoriales 1117|Cyanobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - ko:K19159 - - - - ko00000,ko02048 - - - PhdYeFM_antitox k59_201338_1 765913.ThidrDRAFT_0561 9.43e-148 432.0 COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,1RNM2@1236|Gammaproteobacteria,1X05Q@135613|Chromatiales 135613|Chromatiales C TIGRFAM formylmethanofuran dehydrogenase subunit B - - 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - - k59_201338_2 765913.ThidrDRAFT_0562 4.83e-80 249.0 COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,1RQC1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S beta-ribofuranosylaminobenzene 5'-phosphate synthase - - - - - - - - - - - - GHMP_kinases_C,GHMP_kinases_N k59_6854_1 177437.HRM2_01750 3.07e-111 337.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MHPU@213118|Desulfobacterales 28221|Deltaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_175306_2 886293.Sinac_7402 1.01e-65 244.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,2IXFD@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_175306_3 998088.B565_3225 3.93e-14 71.6 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1Y3KU@135624|Aeromonadales 135624|Aeromonadales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_110527_2 768671.ThimaDRAFT_4051 2.77e-26 107.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_382_1 56780.SYN_01040 2.32e-125 381.0 COG1038@1|root,COG1038@2|Bacteria,1R7P1@1224|Proteobacteria,42PQ3@68525|delta/epsilon subdivisions,2WJK5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Conserved carboxylase domain - - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_45678_1 631362.Thi970DRAFT_01790 5.12e-111 369.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXCR@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS_9 k59_84602_1 439235.Dalk_2476 7.49e-06 53.5 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales 28221|Deltaproteobacteria KLT PFAM Protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase,cNMP_binding k59_78237_1 706587.Desti_5385 7.66e-98 306.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_194736_1 497965.Cyan7822_5247 1.25e-113 379.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3KGDE@43988|Cyanothece 1117|Cyanobacteria T PAS fold-4 domain protein - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_194736_2 748247.AZKH_4491 5.54e-77 244.0 COG3221@1|root,COG3221@2|Bacteria,1MX7I@1224|Proteobacteria,2VP4Q@28216|Betaproteobacteria,2KXM5@206389|Rhodocyclales 206389|Rhodocyclales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_188322_1 522306.CAP2UW1_1910 5.13e-138 412.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_150713_1 926549.KI421517_gene506 1.37e-71 226.0 COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,47MAV@768503|Cytophagia 976|Bacteroidetes E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_14195_1 765911.Thivi_0635 8.25e-07 50.1 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1WW5F@135613|Chromatiales 135613|Chromatiales C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_72687_2 1208321.D104_05590 1.1e-22 96.3 28J26@1|root,2Z8YT@2|Bacteria,1R7S5@1224|Proteobacteria,1RNDH@1236|Gammaproteobacteria,1XMRH@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 k59_72687_4 1163617.SCD_n00988 1.04e-99 298.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2VPZ0@28216|Betaproteobacteria 28216|Betaproteobacteria G deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_33907_4 177437.HRM2_45400 1.64e-29 129.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,42P16@68525|delta/epsilon subdivisions,2WMD4@28221|Deltaproteobacteria,2MPWE@213118|Desulfobacterales 28221|Deltaproteobacteria KL SWIM zinc finger - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_183143_1 1049564.TevJSym_ad00930 7.55e-126 374.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1J4GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_85710_1 1232683.ADIMK_4065 2.07e-20 88.2 COG1433@1|root,COG1433@2|Bacteria,1PW6J@1224|Proteobacteria,1S0X4@1236|Gammaproteobacteria,46BCI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Dinitrogenase iron-molybdenum cofactor, N-terminal - - - - - - - - - - - - DIMCO_N,Nitro_FeMo-Co k59_85710_2 697282.Mettu_3331 9.71e-36 121.0 COG1145@1|root,COG1145@2|Bacteria,1N859@1224|Proteobacteria,1SEBQ@1236|Gammaproteobacteria,1XGQG@135618|Methylococcales 135618|Methylococcales C PFAM 4Fe-4S ferredoxin, iron-sulphur binding, subgroup - - - - - - - - - - - - Fer4 k59_40478_1 1337936.IJ00_04290 9.18e-23 94.7 COG3897@1|root,COG3897@2|Bacteria,1GB73@1117|Cyanobacteria 1117|Cyanobacteria S Methyltransferase - - - - - - - - - - - - Methyltransf_16 k59_40478_2 550540.Fbal_1627 2.81e-31 110.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Cold shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_92306_1 1304885.AUEY01000074_gene594 2.95e-124 378.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2MHVB@213118|Desulfobacterales 28221|Deltaproteobacteria J glycyl-tRNA synthetase, beta glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1263_1 316067.Geob_1422 2.74e-78 248.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,43RZH@69541|Desulfuromonadales 28221|Deltaproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_14200_1 456442.Mboo_1526 1.45e-25 105.0 COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,2NACZ@224756|Methanomicrobia 224756|Methanomicrobia G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_183144_1 380358.XALC_0492 6.53e-31 117.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_183144_2 1249627.D779_0844 3.01e-94 286.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_202522_1 56780.SYN_01264 7.42e-39 134.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MQJI@213462|Syntrophobacterales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_40481_1 1121403.AUCV01000012_gene4110 5.11e-43 167.0 COG0308@1|root,COG3016@1|root,COG0308@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WQAR@28221|Deltaproteobacteria,2MPWA@213118|Desulfobacterales 28221|Deltaproteobacteria EO Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2,Peptidase_M1 k59_176493_1 765912.Thimo_0426 3.16e-99 302.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1WWI5@135613|Chromatiales 135613|Chromatiales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_14201_1 335543.Sfum_3083 1.44e-123 364.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MQ6K@213462|Syntrophobacterales 28221|Deltaproteobacteria F PFAM AICARFT IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_85714_1 519989.ECTPHS_01999 3.81e-36 137.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_85714_2 1240350.AMZE01000018_gene1123 9.27e-07 49.3 2A94G@1|root,30Y8M@2|Bacteria,1PK46@1224|Proteobacteria,1TB78@1236|Gammaproteobacteria,1YZ1E@136845|Pseudomonas putida group 1236|Gammaproteobacteria - - - - - ko:K06950 - - - - ko00000 - - - - k59_20937_4 1078085.HMPREF1210_00388 4.29e-50 171.0 COG0596@1|root,COG0596@2|Bacteria,1V18A@1239|Firmicutes,4HEMC@91061|Bacilli,26I5F@186818|Planococcaceae 91061|Bacilli S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_20937_5 1105031.HMPREF1141_2283 2.15e-41 142.0 COG0346@1|root,COG0346@2|Bacteria,1UFVG@1239|Firmicutes,24K09@186801|Clostridia,36IUZ@31979|Clostridiaceae 186801|Clostridia E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_20937_6 981223.AIED01000017_gene980 4.5e-64 198.0 COG1942@1|root,COG1942@2|Bacteria,1N2V3@1224|Proteobacteria,1SFKB@1236|Gammaproteobacteria,3NN6Y@468|Moraxellaceae 1236|Gammaproteobacteria S Tautomerase enzyme - - - - - - - - - - - - Tautomerase_2 k59_20937_7 224911.27354692 3.45e-131 396.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TV11@28211|Alphaproteobacteria,3JWJD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433,ko:K21801 ko00380,ko00970,ko01100,map00380,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_20937_8 765912.Thimo_0957 2.69e-65 209.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1WYF0@135613|Chromatiales 135613|Chromatiales L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_183153_1 391613.RTM1035_09833 6.35e-43 154.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_111750_1 1049564.TevJSym_ai00820 6.09e-34 122.0 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_7983_1 1158292.JPOE01000002_gene3740 2.82e-177 500.0 COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,1KPA2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Phage integrase SAM-like domain - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_7983_2 1158292.JPOE01000002_gene3741 1.8e-160 457.0 COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2VMDS@28216|Betaproteobacteria,1KKD9@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_7983_3 1123392.AQWL01000031_gene2131 1.2e-160 457.0 COG0582@1|root,COG0582@2|Bacteria,1NZ72@1224|Proteobacteria 1224|Proteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_202536_1 1527444.ucyna2_00497 2.29e-06 54.3 COG0260@1|root,COG0260@2|Bacteria,1G079@1117|Cyanobacteria 1117|Cyanobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_124780_1 323261.Noc_2004 9.55e-19 79.7 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales 135613|Chromatiales S Membrane fusogenic activity - - - ko:K09806 - - - - ko00000 - - - BMFP k59_124780_2 523791.Kkor_0072 2.41e-72 226.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XIJ5@135619|Oceanospirillales 135619|Oceanospirillales O ATPase with chaperone activity comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_20946_2 236097.ADG881_1944 1.13e-23 99.8 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1XJCT@135619|Oceanospirillales 135619|Oceanospirillales O Thioredoxin domain-containing protein trx-1 - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_85722_1 1123401.JHYQ01000003_gene2126 1.74e-206 576.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,461QE@72273|Thiotrichales 72273|Thiotrichales S Alanine dehydrogenase/PNT, C-terminal domain - - - ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_72708_1 1123399.AQVE01000001_gene559 3.66e-154 447.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,45ZWZ@72273|Thiotrichales 72273|Thiotrichales O PFAM Peptidase family M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_98505_1 760117.JN27_02760 1.97e-18 84.3 COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,2VSZR@28216|Betaproteobacteria,476BF@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterised protein family (UPF0149) - - - ko:K07039 - - - - ko00000 - - - SEC-C,UPF0149 k59_98505_2 675814.VIC_003093 9.78e-77 237.0 COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,1XUQY@135623|Vibrionales 135623|Vibrionales S Belongs to the UPF0502 family yceH - - ko:K09915 - - - - ko00000 - - - DUF480 k59_150737_2 1121374.KB891585_gene1832 3.88e-13 77.0 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_150737_3 1049564.TevJSym_ah00850 2.58e-19 86.3 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_79602_1 1121441.AUCX01000010_gene174 6.53e-06 48.9 COG3467@1|root,COG3467@2|Bacteria,1QZ40@1224|Proteobacteria,43CEW@68525|delta/epsilon subdivisions,2X7PV@28221|Deltaproteobacteria,2MHI5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_79602_2 999415.HMPREF9943_00742 4.27e-46 154.0 COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,3VQI5@526524|Erysipelotrichia 526524|Erysipelotrichia O Antioxidant, AhpC TSA family - - - - - - - - - - - - AhpC-TSA k59_105115_1 243233.MCA2507 1.47e-67 206.0 COG2346@1|root,COG2346@2|Bacteria,1QBDD@1224|Proteobacteria,1S8K7@1236|Gammaproteobacteria,1XF6Z@135618|Methylococcales 135618|Methylococcales C Group 1 truncated hemoglobin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_92329_2 62928.azo2959 3.74e-11 61.2 COG0599@1|root,COG0599@2|Bacteria,1P85X@1224|Proteobacteria,2W5YK@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_92329_3 870187.Thini_2670 1.88e-13 73.6 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,1S5DM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_92329_4 1246474.ANBE01000026_gene1798 2.43e-62 199.0 arCOG04078@1|root,2Z8UN@2|Bacteria,2IH5X@201174|Actinobacteria 201174|Actinobacteria S Protoglobin - - - - - - - - - - - - Protoglobin k59_92329_5 857087.Metme_3575 2.15e-10 61.2 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales 135618|Methylococcales C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_195647_1 1212548.B381_09321 4.36e-33 123.0 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,1RMM9@1236|Gammaproteobacteria,1Z0US@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S May be involved in the transport of PQQ or its precursor to the periplasm pqqB GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_195647_2 998674.ATTE01000001_gene3352 2.3e-146 416.0 COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,1RP1V@1236|Gammaproteobacteria,461R8@72273|Thiotrichales 72273|Thiotrichales H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_195647_3 765913.ThidrDRAFT_0530 1.07e-31 113.0 2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,1SCEZ@1236|Gammaproteobacteria,1WZFP@135613|Chromatiales 135613|Chromatiales S coenzyme PQQ synthesis pqqD - - ko:K06138 - - - - ko00000 - - - PqqD k59_189611_1 933262.AXAM01000031_gene3016 3.98e-06 48.5 2EDMA@1|root,337H4@2|Bacteria,1N9ES@1224|Proteobacteria,42VB1@68525|delta/epsilon subdivisions,2WRQZ@28221|Deltaproteobacteria,2MKGP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_189611_2 335543.Sfum_0041 3.23e-39 140.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2WJ57@28221|Deltaproteobacteria,2MQCX@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_27462_1 1049564.TevJSym_ax00410 9.42e-238 671.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3 k59_176519_1 1121422.AUMW01000006_gene691 8.2e-98 300.0 COG1960@1|root,COG1960@2|Bacteria,1TQC8@1239|Firmicutes,24Z4H@186801|Clostridia 186801|Clostridia C PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_163557_2 349163.Acry_0249 0.0007 48.1 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2JQUC@204441|Rhodospirillales 204441|Rhodospirillales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_170273_1 1380391.JIAS01000015_gene111 2.98e-51 175.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,2U1M9@28211|Alphaproteobacteria,2JYEI@204441|Rhodospirillales 204441|Rhodospirillales M ATP-grasp domain - - - - - - - - - - - - Dala_Dala_lig_C k59_131331_2 768671.ThimaDRAFT_2217 2.96e-229 642.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_59892_1 439235.Dalk_5256 4.49e-148 428.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MNIW@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_137458_2 1121430.JMLG01000016_gene381 1.02e-47 155.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_92332_1 1279009.ADICEAN_03421 3.04e-117 352.0 COG1032@1|root,COG1032@2|Bacteria,4NFPW@976|Bacteroidetes,47N80@768503|Cytophagia 976|Bacteroidetes C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_157034_2 1335757.SPICUR_09465 2.87e-122 369.0 28JFR@1|root,2Z99N@2|Bacteria,1R7C5@1224|Proteobacteria,1RZYU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_157034_3 1123228.AUIH01000053_gene3847 1.26e-28 111.0 2EKB4@1|root,33E1H@2|Bacteria,1NJTI@1224|Proteobacteria,1SP34@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_157034_4 383407.XOC_0148 4.18e-40 158.0 COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria,1RY3P@1236|Gammaproteobacteria,1X4BF@135614|Xanthomonadales 135614|Xanthomonadales L exonuclease - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_20967_2 573413.Spirs_3848 1.54e-13 72.4 COG3437@1|root,COG3920@1|root,COG3437@2|Bacteria,COG3920@2|Bacteria 2|Bacteria T Histidine kinase pdtaS - 2.7.13.3 ko:K00936,ko:K02030,ko:K07814,ko:K11527 - M00236,M00839 - - ko00000,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - HATPase_c,HATPase_c_2,H_kinase_N,HisKA,HisKA_2,PAS,Response_reg k59_137459_1 1265505.ATUG01000002_gene1161 4.45e-77 238.0 COG0407@1|root,COG0407@2|Bacteria,1PXIF@1224|Proteobacteria,42SKI@68525|delta/epsilon subdivisions,2WPBF@28221|Deltaproteobacteria,2MKAD@213118|Desulfobacterales 28221|Deltaproteobacteria H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_107162_1 998674.ATTE01000001_gene2066 8.8e-13 72.0 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Type IV pilus biogenesis stability protein PilW pilF - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - LysM,TPR_12,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8 k59_2968_1 543728.Vapar_5982 2.45e-24 105.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2VKSJ@28216|Betaproteobacteria,4ACTJ@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_2968_2 395494.Galf_0998 3.12e-25 102.0 2F1SA@1|root,33USF@2|Bacteria,1NVHZ@1224|Proteobacteria,2W20M@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_2968_3 765913.ThidrDRAFT_3877 7.43e-07 49.3 COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,1RNUG@1236|Gammaproteobacteria,1WY4E@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - - - - - - - - - - - Oxidored_q6 k59_191639_1 1049564.TevJSym_ac01250 1.04e-37 140.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1J5DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_191639_2 1122134.KB893650_gene574 4.85e-16 77.4 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1XI7V@135619|Oceanospirillales 135619|Oceanospirillales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_81619_1 96561.Dole_0429 2.77e-20 87.0 COG3678@1|root,COG3678@2|Bacteria,1NKPX@1224|Proteobacteria,438FB@68525|delta/epsilon subdivisions,2X3QB@28221|Deltaproteobacteria,2MMEE@213118|Desulfobacterales 28221|Deltaproteobacteria NPTU Heavy-metal resistance - - - ko:K07803 ko02020,map02020 - - - ko00000,ko00001,ko03110 - - - Metal_resist k59_87834_1 1304885.AUEY01000020_gene3514 4.74e-13 69.7 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_87834_2 335543.Sfum_0006 3.39e-69 220.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2MQCV@213462|Syntrophobacterales 28221|Deltaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_10220_1 1121405.dsmv_3107 5.67e-116 355.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MJ5T@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_191641_1 768671.ThimaDRAFT_4529 1.46e-80 249.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_95091_1 439235.Dalk_5190 4.97e-107 328.0 COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_165475_2 871585.BDGL_001417 4.94e-31 113.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,3NNJH@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin,Rhodanese k59_165475_3 95619.PM1_0206425 1.67e-06 48.9 COG5007@1|root,COG5007@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding yrbA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - BolA k59_165475_4 1232683.ADIMK_4065 4.04e-29 111.0 COG1433@1|root,COG1433@2|Bacteria,1PW6J@1224|Proteobacteria,1S0X4@1236|Gammaproteobacteria,46BCI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Dinitrogenase iron-molybdenum cofactor, N-terminal - - - - - - - - - - - - DIMCO_N,Nitro_FeMo-Co k59_55082_2 2340.JV46_18600 8.38e-152 429.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1J5IF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iYL1228.KPN_02481 His_biosynth k59_23197_1 1049564.TevJSym_aq00450 1.04e-57 186.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1J4Q3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt k59_23197_2 1049564.TevJSym_aq00440 8.1e-317 868.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_36258_1 1121405.dsmv_3293 0.000166 42.7 COG4770@1|root,COG4770@2|Bacteria 2|Bacteria I CoA carboxylase activity pccA GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681 2.1.3.1,4.1.1.70,6.4.1.3 ko:K01615,ko:K01965,ko:K02160,ko:K17490 ko00061,ko00280,ko00362,ko00620,ko00630,ko00640,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00362,map00620,map00630,map00640,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00353,R00742,R01859,R03028 RC00040,RC00097,RC00367,RC00609,RC00832 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.3 - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_3111_1 1504981.KO116_3186 1.49e-18 81.3 2ENF2@1|root,33G2I@2|Bacteria,1NGH7@1224|Proteobacteria,1SIED@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_3111_2 1144325.PMI22_03541 1.07e-123 380.0 COG4974@1|root,COG4974@2|Bacteria,1RBV2@1224|Proteobacteria,1S4A9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L integrase family - - - - - - - - - - - - Phage_integrase k59_197641_2 1049564.TevJSym_aa01270 6.81e-159 448.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,1RMJ2@1236|Gammaproteobacteria,1J4WA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_197641_3 472759.Nhal_2328 2.14e-80 247.0 COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,1RNVX@1236|Gammaproteobacteria,1WWVR@135613|Chromatiales 135613|Chromatiales N TIGRFAM flagellar basal-body rod protein FlgF - - - ko:K02391 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_197644_1 1121405.dsmv_1706 6.16e-41 144.0 COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2MIE6@213118|Desulfobacterales 28221|Deltaproteobacteria EG PFAM EamA-like transporter family - - - - - - - - - - - - EamA k59_62218_1 1225184.ALXE01000039_gene3073 0.000242 42.7 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,3W0UJ@53335|Pantoea 1236|Gammaproteobacteria KT Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_62218_2 527002.yaldo0001_28400 7.51e-07 57.8 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1RQGM@1236|Gammaproteobacteria,41F6C@629|Yersinia 1236|Gammaproteobacteria T to Sensor protein of Enterobacteriaceae UniRef RepID Q9FA47_9ENTR tctE - 2.7.13.3 ko:K07645,ko:K07649 ko02020,ko02024,map02020,map02024 M00453,M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HAMP,HATPase_c,HisKA k59_139412_1 243159.AFE_0937 2.46e-84 262.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,2NCF3@225057|Acidithiobacillales 225057|Acidithiobacillales C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases k59_120805_3 1034943.BN1094_01236 3.75e-07 57.8 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1JD13@118969|Legionellales 118969|Legionellales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_120805_4 383407.XOC_0657 1.36e-40 140.0 2EN2S@1|root,33FQY@2|Bacteria,1NHAQ@1224|Proteobacteria,1STBD@1236|Gammaproteobacteria,1XAYI@135614|Xanthomonadales 135614|Xanthomonadales S Avidin family - - - - - - - - - - - - Avidin k59_120805_5 268407.PWYN_24025 1.22e-12 70.5 COG1670@1|root,COG1670@2|Bacteria,1V0KT@1239|Firmicutes,4HURK@91061|Bacilli,274T2@186822|Paenibacillaceae 91061|Bacilli J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_120805_6 246197.MXAN_0593 6.49e-60 209.0 COG1819@1|root,COG1819@2|Bacteria,1QWRW@1224|Proteobacteria 1224|Proteobacteria CG Belongs to the UDP-glycosyltransferase family crtX - 2.4.1.276 ko:K14596 ko00906,map00906 - R07574 RC00005,RC01992 ko00000,ko00001,ko01000,ko01003 - GT1 - Glyco_tran_28_C,UDPGT k59_178861_1 515635.Dtur_0748 9.13e-26 110.0 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity saeS - 2.7.13.3,4.6.1.1 ko:K01768,ko:K02484,ko:K07636,ko:K10681,ko:K10819,ko:K18350,ko:K20487 ko00230,ko01502,ko02020,ko02024,ko02025,ko04113,ko04213,map00230,map01502,map02020,map02024,map02025,map04113,map04213 M00434,M00468,M00652,M00657,M00695,M00816 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA k59_172144_1 1125863.JAFN01000001_gene3148 2.18e-44 162.0 COG0457@1|root,COG0501@1|root,COG0457@2|Bacteria,COG0501@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria 28221|Deltaproteobacteria O peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48,TPR_11,TPR_17 k59_133474_1 696369.KI912183_gene1805 2.39e-56 198.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,260Y1@186807|Peptococcaceae 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_152598_1 243233.MCA1899 1.12e-149 427.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XE1W@135618|Methylococcales 135618|Methylococcales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_49044_1 1356852.N008_19705 1.96e-34 137.0 COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,47KSG@768503|Cytophagia 976|Bacteroidetes E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_49044_2 314345.SPV1_09298 3.93e-316 875.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria 1224|Proteobacteria H Catalyzes the biosynthesis of agmatine from arginine speA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iIT341.HP0422,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283 Orn_Arg_deC_N k59_107408_1 1504672.669787300 2.72e-40 143.0 COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,4AAJH@80864|Comamonadaceae 28216|Betaproteobacteria S Virulence factor BrkB - - - - - - - - - - - - Virul_fac_BrkB k59_107408_2 1278307.KB907043_gene2383 2.97e-37 138.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,2QHY6@267894|Psychromonadaceae 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_29478_1 1245471.PCA10_46850 4.45e-23 93.2 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1YDPY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_29478_3 93220.LV28_11300 4.1e-17 82.4 2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,2VUU0@28216|Betaproteobacteria,1K3AV@119060|Burkholderiaceae 28216|Betaproteobacteria S CNP1-like family - - - - - - - - - - - - CNP1 k59_87854_1 1167006.UWK_01869 1.49e-141 417.0 28J96@1|root,2Z947@2|Bacteria,1R6TE@1224|Proteobacteria,42PZG@68525|delta/epsilon subdivisions,2WIKY@28221|Deltaproteobacteria,2MHY0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Oligopeptide transporter OPT superfamily - - - - - - - - - - - - - k59_133478_1 177439.DP2235 3.12e-17 84.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_95111_1 1401065.HMPREF2130_10730 8.03e-23 95.5 28HX7@1|root,2Z82Y@2|Bacteria,1R7X5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_16030_1 639282.DEFDS_0769 4.39e-240 672.0 COG0146@1|root,COG0146@2|Bacteria,2GGAB@200930|Deferribacteres 200930|Deferribacteres EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_62230_1 879212.DespoDRAFT_01479 4.48e-77 246.0 COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_81639_1 1123248.KB893316_gene4600 6.12e-14 83.6 COG1749@1|root,COG3055@1|root,COG1749@2|Bacteria,COG3055@2|Bacteria,4NTUT@976|Bacteroidetes 976|Bacteroidetes N Domain of unknown function (DUF4082) - - - - - - - - - - - - Cu-binding_MopE,DUF4082 k59_165501_1 398767.Glov_1680 1.03e-152 441.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_178870_2 765913.ThidrDRAFT_2928 3.21e-69 226.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,1WVWP@135613|Chromatiales 135613|Chromatiales T PFAM ATP-binding region - - 2.7.13.3 ko:K19661 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4 k59_10256_1 288000.BBta_1460 1.89e-137 410.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_43348_1 228399.appser1_6070 1.6e-32 123.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1Y77G@135625|Pasteurellales 135625|Pasteurellales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_204499_1 696281.Desru_0556 4.89e-71 229.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,2611T@186807|Peptococcaceae 186801|Clostridia C Belongs to the Glu Leu Phe Val dehydrogenases family gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0071704,GO:1901564 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_159269_1 880072.Desac_2367 1.5e-39 148.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria 1224|Proteobacteria T Adenylate cyclase - - - - - - - - - - - - - k59_133490_1 96561.Dole_0756 4.58e-80 250.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_95327_1 1397284.AYMN01000049_gene978 3.17e-10 66.6 COG4388@1|root,COG4388@2|Bacteria,1R5B8@1224|Proteobacteria,1RQUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_23410_1 1049564.TevJSym_al00380 3.49e-246 706.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1J4XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_191771_1 1049564.TevJSym_ab01990 2.31e-63 197.0 COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP synthase subunit C - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k59_191771_2 580332.Slit_2554 1.3e-16 76.6 COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,2W5EY@28216|Betaproteobacteria 28216|Betaproteobacteria C ATP synthase (F/14-kDa) subunit - - - - - - - - - - - - ATP-synt_F k59_191771_3 1049564.TevJSym_ab01970 8.89e-64 203.0 COG1390@1|root,COG1390@2|Bacteria,1R8BT@1224|Proteobacteria,1S1WN@1236|Gammaproteobacteria 1236|Gammaproteobacteria C V-type proton ATPase subunit E - - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E k59_191771_4 1049564.TevJSym_ab01960 5.38e-110 335.0 COG1155@1|root,COG1155@2|Bacteria,1R22G@1224|Proteobacteria 1224|Proteobacteria C ATPsynthase alpha/beta subunit N-term extension - - - - - - - - - - - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_68838_1 1266925.JHVX01000003_gene445 3.69e-23 97.1 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,372D3@32003|Nitrosomonadales 28216|Betaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family cbbR - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_68838_2 159087.Daro_3637 2.6e-10 60.1 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,2KV1C@206389|Rhodocyclales 206389|Rhodocyclales H RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site rbcL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_165660_1 933262.AXAM01000069_gene2684 1.01e-84 266.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_74673_1 1265505.ATUG01000001_gene4080 1.25e-36 133.0 COG0727@1|root,COG0727@2|Bacteria,1Q0JM@1224|Proteobacteria,42N6S@68525|delta/epsilon subdivisions,2WMTR@28221|Deltaproteobacteria,2MIXY@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_193685_1 243231.GSU2053 2.5e-89 281.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,43UAV@69541|Desulfuromonadales 28221|Deltaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA-2 - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_12595_1 909663.KI867150_gene487 1.45e-16 80.1 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2MQC9@213462|Syntrophobacterales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_161596_1 768671.ThimaDRAFT_2747 1.23e-40 167.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1R6BM@1224|Proteobacteria,1RRQG@1236|Gammaproteobacteria,1WWNE@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,Response_reg k59_161596_2 1123487.KB892841_gene4322 4.73e-12 62.8 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,2KW72@206389|Rhodocyclales 206389|Rhodocyclales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_76801_1 869213.JCM21142_41386 9.68e-31 117.0 COG2043@1|root,COG2043@2|Bacteria 2|Bacteria C Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_38842_1 1265505.ATUG01000002_gene1107 2.31e-28 108.0 COG1143@1|root,COG1143@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - - - - - - - - - - Fer4,Fer4_6 k59_167715_1 309807.SRU_2143 7.45e-45 165.0 COG1138@1|root,COG1138@2|Bacteria,4NGXI@976|Bacteroidetes,1FIPV@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Cytochrome c-type biogenesis protein CcmF C-terminal ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_206583_3 243231.GSU1945 7.04e-05 48.9 COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_3 k59_206583_4 768671.ThimaDRAFT_0366 9.84e-96 287.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1WVUK@135613|Chromatiales 135613|Chromatiales C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_141835_1 765914.ThisiDRAFT_2078 2.77e-66 221.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_148592_1 929558.SMGD1_1075 8.46e-11 65.5 COG2203@1|root,COG2203@2|Bacteria,1R0Y5@1224|Proteobacteria,42NT7@68525|delta/epsilon subdivisions,2YRW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GAF domain - - - - - - - - - - - - GAF k59_51436_1 1040989.AWZU01000004_gene7043 2.91e-27 113.0 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,3JUK3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_90154_1 439235.Dalk_2017 7.82e-16 82.0 COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2MJCH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_148598_1 1379698.RBG1_1C00001G0608 6.56e-24 105.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N k59_102727_1 1121918.ARWE01000001_gene1672 1.54e-35 123.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,42TVD@68525|delta/epsilon subdivisions,2WQPX@28221|Deltaproteobacteria,43SP9@69541|Desulfuromonadales 28221|Deltaproteobacteria L Belongs to the bacterial histone-like protein family ihfB - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_90156_2 1049564.TevJSym_bq00070 4.7e-106 325.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_76810_1 1049564.TevJSym_ae00330 2.11e-59 206.0 28IG4@1|root,2Z8HN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_25642_1 1049564.TevJSym_at00540 1.72e-85 262.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1J50S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, ATPase PilU uptC - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_25642_2 1049564.TevJSym_at00530 1.75e-17 82.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1J8TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_102733_1 1267535.KB906767_gene5379 2.15e-17 85.1 COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria,2JJPA@204432|Acidobacteriia 204432|Acidobacteriia L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1,RVT_N k59_180932_2 335543.Sfum_0378 1.59e-124 366.0 COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,42PYP@68525|delta/epsilon subdivisions,2WMA1@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_51450_1 555079.Toce_2133 3.95e-73 241.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_18471_1 1232437.KL662039_gene2059 4.56e-39 140.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MI5I@213118|Desulfobacterales 28221|Deltaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_173943_1 234267.Acid_5780 6.47e-10 70.1 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C k59_206587_1 1089553.Tph_c25320 1.05e-90 296.0 COG5421@1|root,COG5421@2|Bacteria,1UYTK@1239|Firmicutes,24G1G@186801|Clostridia,42J2Y@68295|Thermoanaerobacterales 186801|Clostridia L Domain of unknown function (DUF4277) - - - - - - - - - - - - DDE_Tnp_1,DUF4277 k59_18475_1 933262.AXAM01000013_gene1324 1.05e-14 75.5 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_64580_1 269482.Bcep1808_1783 1.99e-25 101.0 COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria,1K7NX@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_64580_2 1049564.TevJSym_ba00320 8.99e-73 224.0 28P01@1|root,2ZBWR@2|Bacteria,1RB5K@1224|Proteobacteria,1S2PB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_167731_1 690850.Desaf_2364 1.46e-121 367.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_167731_2 1123228.AUIH01000009_gene1940 9.48e-18 80.9 28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria,1S0GG@1236|Gammaproteobacteria,1XNAN@135619|Oceanospirillales 135619|Oceanospirillales S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_12628_1 59538.XP_005967236.1 3.01e-06 49.3 COG0621@1|root,KOG2492@2759|Eukaryota,38E0X@33154|Opisthokonta,3BEN9@33208|Metazoa,3CXYH@33213|Bilateria,485R3@7711|Chordata,4956Z@7742|Vertebrata,3J2G5@40674|Mammalia 59538.XP_005967236.1|- T CDK5 regulatory subunit associated protein 1 - - - - - - - - - - - - - k59_12628_2 555779.Dthio_PD1159 4.01e-28 115.0 COG0664@1|root,COG0664@2|Bacteria,1QZ42@1224|Proteobacteria,42XK7@68525|delta/epsilon subdivisions,2WSIV@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_31726_1 345341.KUTG_07242 6.85e-11 67.0 COG3469@1|root,COG3469@2|Bacteria,2GJH0@201174|Actinobacteria,4DZGS@85010|Pseudonocardiales 201174|Actinobacteria G Carbohydrate binding domain chiA - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - CBM_2,CBM_4_9,CBM_5_12,Glyco_hydro_18,fn3 k59_161630_2 5911.EAR99658 8.03e-06 56.2 COG2074@1|root,2QR37@2759|Eukaryota,3ZBWF@5878|Ciliophora 5878|Ciliophora G myo-inositol hexakisphosphate metabolic process - - - ko:K05715 - - R02664 RC00002,RC00017 ko00000,ko01000 - - - - k59_180938_1 1049564.TevJSym_at00530 0.0 931.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1J8TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_109808_1 713586.KB900536_gene1978 1.49e-91 280.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_109808_3 857087.Metme_1124 2.49e-144 481.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_57441_1 933262.AXAM01000014_gene268 1.42e-95 286.0 COG1032@1|root,COG1032@2|Bacteria,1MYYB@1224|Proteobacteria,42N3I@68525|delta/epsilon subdivisions,2WIPK@28221|Deltaproteobacteria,2MJDH@213118|Desulfobacterales 28221|Deltaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_206777_1 1137799.GZ78_00900 7.42e-12 62.4 COG1943@1|root,COG1943@2|Bacteria,1RI1H@1224|Proteobacteria,1T1BV@1236|Gammaproteobacteria,1XQ50@135619|Oceanospirillales 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_206777_2 1121035.AUCH01000004_gene429 0.0 2044.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_206777_3 1545915.JROG01000008_gene3461 0.000719 43.5 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2K0RQ@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_206777_4 445975.COLSTE_01696 8.25e-38 137.0 COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria,4CYFZ@84998|Coriobacteriia 84998|Coriobacteriia V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_206777_5 396588.Tgr7_1994 1.07e-05 52.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales 135613|Chromatiales V ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_90519_1 1366050.N234_10795 3.2e-242 703.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_90519_2 1449976.KALB_2150 1.32e-31 120.0 COG1309@1|root,COG1309@2|Bacteria,2HX7D@201174|Actinobacteria,4E321@85010|Pseudonocardiales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_13,TetR_C_6,TetR_N k59_161983_1 335543.Sfum_2499 1.93e-56 192.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,42NAN@68525|delta/epsilon subdivisions,2WKXF@28221|Deltaproteobacteria,2MR9R@213462|Syntrophobacterales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase k59_174297_1 395965.Msil_0241 1.64e-89 299.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,3NAE1@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_116256_1 1304885.AUEY01000001_gene3189 7.8e-96 290.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_116256_2 882.DVU_0533 2.51e-10 57.0 2AHWG@1|root,3189B@2|Bacteria,1NMDE@1224|Proteobacteria,42WZC@68525|delta/epsilon subdivisions,2WTDJ@28221|Deltaproteobacteria,2ME0P@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - - k59_194157_1 1236689.MMALV_16800 1.07e-42 158.0 COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,3F2HN@33867|unclassified Euryarchaeota 28890|Euryarchaeota L MCM OB domain mcm - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB k59_57458_1 387093.SUN_2303 9.12e-19 85.9 2DW5W@1|root,33YP2@2|Bacteria,1Q5AU@1224|Proteobacteria,430XF@68525|delta/epsilon subdivisions,2YS2U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_77136_1 1123399.AQVE01000012_gene2927 2.42e-08 60.8 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,460ZY@72273|Thiotrichales 72273|Thiotrichales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_12916_2 1120999.JONM01000037_gene2109 2.6e-100 322.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,2VKF9@28216|Betaproteobacteria,2KR53@206351|Neisseriales 206351|Neisseriales G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_51783_1 1195236.CTER_0666 2.15e-55 192.0 COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3WHC5@541000|Ruminococcaceae 186801|Clostridia L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_142227_1 1304885.AUEY01000037_gene2180 6.06e-53 176.0 COG0135@1|root,COG0135@2|Bacteria,1RFH8@1224|Proteobacteria,42RT5@68525|delta/epsilon subdivisions,2WNTK@28221|Deltaproteobacteria,2MK21@213118|Desulfobacterales 28221|Deltaproteobacteria E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_57464_1 439235.Dalk_1443 8.16e-74 239.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MPUA@213118|Desulfobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - MFS_1,OEP k59_32130_1 1116472.MGMO_56c00080 1.87e-71 225.0 28NP4@1|root,2ZBP4@2|Bacteria,1NK54@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_103030_1 1134413.ANNK01000176_gene2475 4.04e-37 137.0 COG1484@1|root,COG1484@2|Bacteria,1TQ6K@1239|Firmicutes,4HDG7@91061|Bacilli,1ZRPD@1386|Bacillus 91061|Bacilli L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_181203_1 573413.Spirs_1898 7.47e-05 44.7 COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes 203691|Spirochaetes S FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_12924_1 1134474.O59_002624 1.14e-93 301.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1FHVM@10|Cellvibrio 1236|Gammaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_90530_3 1231391.AMZF01000017_gene177 6.68e-37 131.0 COG1846@1|root,COG1846@2|Bacteria,1N150@1224|Proteobacteria,2VVF3@28216|Betaproteobacteria 28216|Betaproteobacteria K Regulatory protein MarR hcaR - - - - - - - - - - - MarR,MarR_2 k59_5544_2 247490.KSU1_B0541 5.78e-62 198.0 COG1238@1|root,COG1238@2|Bacteria,2J05B@203682|Planctomycetes 203682|Planctomycetes S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_142238_1 177437.HRM2_30880 9.94e-52 166.0 COG1908@1|root,COG1908@2|Bacteria,1N4XV@1224|Proteobacteria,42UTE@68525|delta/epsilon subdivisions,2WQE3@28221|Deltaproteobacteria,2MKMT@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_116284_1 1167006.UWK_02231 2.16e-74 239.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_174308_1 870187.Thini_1858 3.18e-49 178.0 COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,461QI@72273|Thiotrichales 72273|Thiotrichales S Belongs to the UPF0753 family - - - - - - - - - - - - DUF2309 k59_181212_1 335543.Sfum_3396 7.47e-16 75.5 COG0410@1|root,COG0410@2|Bacteria,1PFBJ@1224|Proteobacteria,42ZBI@68525|delta/epsilon subdivisions,2WUAI@28221|Deltaproteobacteria,2MRM9@213462|Syntrophobacterales 28221|Deltaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_181212_2 913865.DOT_3189 1.12e-36 134.0 COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,260FQ@186807|Peptococcaceae 186801|Clostridia E Branched-chain amino acid ATP-binding cassette transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_25845_2 1408438.JADD01000033_gene531 6.42e-93 306.0 COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,4H9Z7@91061|Bacilli 91061|Bacilli L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_21673_2 177437.HRM2_22100 7.31e-16 79.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_196114_1 1049564.TevJSym_aw00420 1.35e-53 179.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1S294@1236|Gammaproteobacteria,1J60E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_60377_1 269799.Gmet_0583 3.02e-144 434.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Spermine spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_170895_1 2340.JV46_08150 1.37e-90 305.0 COG3291@1|root,COG3291@2|Bacteria,1PDUK@1224|Proteobacteria,1S8QS@1236|Gammaproteobacteria,1JBTK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PKD domain - - - - - - - - - - - - PKD,PPC,Peptidase_M43 k59_125462_1 56780.SYN_02160 6.09e-37 136.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MQ57@213462|Syntrophobacterales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_125462_2 710393.HSUHS1_0071 3.94e-18 84.3 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2YMC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0566 DAP_epimerase k59_8549_1 50960.LS81_10005 3.97e-17 85.5 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2YMTU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_8549_2 1121403.AUCV01000012_gene4083 2.44e-13 72.4 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MICP@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_112280_1 686340.Metal_2521 1.06e-107 332.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales 135618|Methylococcales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_112280_3 765912.Thimo_3629 2.96e-116 341.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1WX0V@135613|Chromatiales 135613|Chromatiales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_112280_4 1049564.TevJSym_ai00080 2.75e-131 380.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1J4PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt k59_73159_1 1217705.F900_01885 2.93e-70 233.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase A - 3.1.21.4 ko:K21512 - - - - ko00000,ko01000 - - - Terminase_GpA k59_157572_1 522306.CAP2UW1_1620 2.27e-29 113.0 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VJXC@28216|Betaproteobacteria,1KQNM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_177152_1 477228.YO5_08983 1.13e-161 478.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1Z0JC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnD GO:0003674,GO:0003824,GO:0003994,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575 4.2.1.117,4.2.1.3 ko:K01681,ko:K20455 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900,R11263 RC00497,RC00498,RC00618,RC01152 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_34531_1 877455.Metbo_1606 1.61e-41 155.0 COG3177@1|root,arCOG03110@2157|Archaea,2XUN8@28890|Euryarchaeota,23PGE@183925|Methanobacteria 183925|Methanobacteria K Fic/DOC family - - - - - - - - - - - - Fic,HTH_24 k59_144894_1 555778.Hneap_0791 6.47e-95 286.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQPA@1236|Gammaproteobacteria,1X2CQ@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_73163_1 1123373.ATXI01000005_gene900 2e-19 92.4 COG1208@1|root,COG3178@1|root,COG1208@2|Bacteria,COG3178@2|Bacteria,2GHXN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria JM Ecdysteroid kinase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH,NTP_transferase k59_60383_1 879212.DespoDRAFT_02312 8.35e-96 293.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II secretion system pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_105617_1 948106.AWZT01000007_gene3536 8.91e-62 194.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1K11Z@119060|Burkholderiaceae 28216|Betaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_105617_2 314287.GB2207_01957 3.28e-09 55.8 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1J5XT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_170906_2 1469607.KK073769_gene5163 4.42e-26 102.0 COG3222@1|root,COG3222@2|Bacteria,1G536@1117|Cyanobacteria,1HJHU@1161|Nostocales 1117|Cyanobacteria S protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_47395_1 909663.KI867150_gene1836 6.75e-27 105.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,2MQ4G@213462|Syntrophobacterales 28221|Deltaproteobacteria J PFAM glycyl-tRNA synthetase, alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_2942 tRNA-synt_2e k59_27987_1 56780.SYN_00992 1.19e-67 207.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,2MQGG@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_27987_2 883112.HMPREF9707_00195 2.8e-17 75.1 COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,4HNUP@91061|Bacilli,27E4Z@186827|Aerococcaceae 91061|Bacilli J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_27987_3 644282.Deba_2929 4.07e-32 113.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,42TNS@68525|delta/epsilon subdivisions,2WR6G@28221|Deltaproteobacteria 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_131963_1 56110.Oscil6304_3385 1.01e-40 154.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG5002@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 2|Bacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg k59_131963_2 1038860.AXAP01000143_gene4098 2.79e-10 57.4 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,3K6ZS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT cheY-homologous receiver domain divK - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_21707_1 880073.Calab_0515 4.45e-72 229.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_105625_1 247490.KSU1_C1703 7.55e-52 177.0 COG4424@1|root,COG4424@2|Bacteria 2|Bacteria S carbohydrate metabolic process - - - - - - - - - - - - Sulfotransfer_1,Sulfotransfer_3 k59_119013_1 933262.AXAM01000029_gene2729 1.27e-74 231.0 COG0655@1|root,COG0655@2|Bacteria,1RCDV@1224|Proteobacteria,42R2V@68525|delta/epsilon subdivisions,2WN0P@28221|Deltaproteobacteria,2MJJM@213118|Desulfobacterales 28221|Deltaproteobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_66716_1 1123228.AUIH01000091_gene569 3.81e-34 135.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_170915_1 1232437.KL661982_gene3741 6.97e-14 69.7 COG1456@1|root,COG1456@2|Bacteria,1R9BV@1224|Proteobacteria,42P65@68525|delta/epsilon subdivisions,2WMGX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Fe-S cluster domain protein - - - - - - - - - - - - DUF3786,FeS k59_170915_2 335543.Sfum_1907 6.02e-15 73.9 COG0583@1|root,COG0583@2|Bacteria,1N8HZ@1224|Proteobacteria,43AMN@68525|delta/epsilon subdivisions,2X61Q@28221|Deltaproteobacteria,2MQU7@213462|Syntrophobacterales 28221|Deltaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_184195_1 1249627.D779_3613 3.67e-89 274.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_184195_2 243233.MCA2744 1.46e-46 151.0 COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,1S3XZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Ribulose bisphosphate carboxylase, small chain - - 4.1.1.39 ko:K01602 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_small k59_119277_2 999547.KI421500_gene3551 6.85e-10 62.8 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2823D@191028|Leisingera 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_86581_1 13689.BV96_04745 4.56e-93 298.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - - - - - - - - - - rve k59_138134_1 648757.Rvan_2960 5.2e-23 99.8 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3N7RY@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_105905_1 1307759.JOMJ01000004_gene2844 1.41e-64 219.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2M7Z1@213115|Desulfovibrionales 28221|Deltaproteobacteria V ABC transporter, transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_112507_3 1439940.BAY1663_02252 1.59e-10 67.4 COG0457@1|root,COG2064@1|root,COG0457@2|Bacteria,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,1RTD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU type II secretion system protein tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_53950_1 396588.Tgr7_0485 4.24e-15 77.8 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1WX4D@135613|Chromatiales 135613|Chromatiales O PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_86582_1 765913.ThidrDRAFT_3584 1.58e-10 58.9 COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,1SHX0@1236|Gammaproteobacteria,1WZKQ@135613|Chromatiales 135613|Chromatiales T Belongs to the anti-sigma-factor antagonist family - - - - - - - - - - - - STAS k59_119279_1 879212.DespoDRAFT_02050 3.05e-53 177.0 COG3170@1|root,COG3170@2|Bacteria,1REZ7@1224|Proteobacteria,42RFW@68525|delta/epsilon subdivisions,2WNBB@28221|Deltaproteobacteria,2MK5J@213118|Desulfobacterales 28221|Deltaproteobacteria NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_119279_2 96561.Dole_1554 6.94e-26 105.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,42PNZ@68525|delta/epsilon subdivisions,2WM13@28221|Deltaproteobacteria,2MJSE@213118|Desulfobacterales 28221|Deltaproteobacteria C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_203269_2 97139.C824_04890 5.93e-72 219.0 COG1943@1|root,COG1943@2|Bacteria,1V53Y@1239|Firmicutes,25CMQ@186801|Clostridia,36VU7@31979|Clostridiaceae 186801|Clostridia L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_112510_1 439235.Dalk_3206 4.26e-71 225.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MIAD@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_8843_1 1123392.AQWL01000028_gene16 4.24e-68 207.0 COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2VSDW@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_8843_2 522306.CAP2UW1_4556 1.25e-50 161.0 COG5606@1|root,COG5606@2|Bacteria,1NA3S@1224|Proteobacteria,2VT34@28216|Betaproteobacteria 28216|Betaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_41539_2 1392489.JPOL01000002_gene1132 5.66e-21 90.5 COG0819@1|root,COG0819@2|Bacteria,4NG9P@976|Bacteroidetes,1HYXE@117743|Flavobacteriia,2XIPS@283735|Leeuwenhoekiella 976|Bacteroidetes K TENA/THI-4/PQQC family tenA - 3.5.99.2 ko:K03707 ko00730,ko01100,map00730,map01100 - R02133,R09993 RC00224,RC00652,RC02832 ko00000,ko00001,ko01000,ko03000 - - - TENA_THI-4 k59_86583_1 768671.ThimaDRAFT_2383 1.64e-15 71.2 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_86583_2 1049564.TevJSym_ai00970 2.67e-176 514.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_93371_1 395493.BegalDRAFT_1531 1.58e-07 51.6 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,1S274@1236|Gammaproteobacteria,463J5@72273|Thiotrichales 72273|Thiotrichales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_112516_1 1249627.D779_1318 5.73e-103 315.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_73379_2 272943.RSP_2403 1.58e-48 170.0 COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,1FCQV@1060|Rhodobacter 28211|Alphaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_47625_1 765912.Thimo_3238 7.67e-59 190.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,1S4H2@1236|Gammaproteobacteria,1WXZI@135613|Chromatiales 135613|Chromatiales C Hydrogenase expression formation protein - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_47625_2 697282.Mettu_4134 5.19e-25 98.2 COG0526@1|root,COG0526@2|Bacteria,1RJ41@1224|Proteobacteria,1T3Z2@1236|Gammaproteobacteria,1XGF3@135618|Methylococcales 135618|Methylococcales CO PFAM Hydrogenase-1 expression HyaE - - - ko:K03619 - - - - ko00000 - - - HyaE k59_177483_1 765912.Thimo_2695 5.07e-12 67.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_132227_1 1120998.AUFC01000023_gene2180 1.55e-64 211.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,3WD46@538999|Clostridiales incertae sedis 186801|Clostridia E Aminotransferase class-V csd2 - - - - - - - - - - - Aminotran_5 k59_53961_1 643648.Slip_1606 3.87e-42 149.0 COG1484@1|root,COG1484@2|Bacteria,1UYIT@1239|Firmicutes,24DFX@186801|Clostridia,42KKU@68298|Syntrophomonadaceae 186801|Clostridia L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_99244_1 1345695.CLSA_c37020 1.37e-19 97.1 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_67038_1 1125863.JAFN01000001_gene3549 2.02e-91 293.0 COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,42UPY@68525|delta/epsilon subdivisions,2WQZZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_41552_1 1121405.dsmv_3553 5.17e-11 61.2 COG4232@1|root,COG4232@2|Bacteria,1PK9S@1224|Proteobacteria,42PV0@68525|delta/epsilon subdivisions,2WJPK@28221|Deltaproteobacteria,2MIJ0@213118|Desulfobacterales 28221|Deltaproteobacteria CO PFAM Cytochrome C biogenesis protein transmembrane region dsbD - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_41552_2 177437.HRM2_48270 9.71e-48 157.0 COG0526@1|root,COG0526@2|Bacteria,1N0R9@1224|Proteobacteria,42UD9@68525|delta/epsilon subdivisions,2WQ0H@28221|Deltaproteobacteria,2MK3U@213118|Desulfobacterales 28221|Deltaproteobacteria CO Thioredoxin trx-2 - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_203284_1 1009370.ALO_15232 1.65e-73 235.0 28MXM@1|root,2ZB4M@2|Bacteria,1UYF1@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_196421_1 96561.Dole_1634 2.52e-33 125.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria,2MI5R@213118|Desulfobacterales 28221|Deltaproteobacteria P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto k59_119304_1 1379698.RBG1_1C00001G0172 2.57e-31 120.0 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_171129_1 713586.KB900536_gene1581 3.57e-32 118.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1WYEN@135613|Chromatiales 135613|Chromatiales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_171129_2 765912.Thimo_3135 1.82e-42 147.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales 135613|Chromatiales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_159891_1 998088.B565_0220 2.14e-13 71.6 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1Y3QU@135624|Aeromonadales 135624|Aeromonadales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_159891_2 1121405.dsmv_0171 2.16e-104 329.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria,2MI96@213118|Desulfobacterales 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,UvrD_C_2 k59_121508_1 292415.Tbd_2670 6.52e-71 227.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,1KRQP@119069|Hydrogenophilales 119069|Hydrogenophilales T HD domain - - - ko:K13815 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko02022 - - - HD,Response_reg k59_23802_2 765912.Thimo_3476 2.93e-52 167.0 COG5642@1|root,COG5642@2|Bacteria,1N2DF@1224|Proteobacteria,1S93Q@1236|Gammaproteobacteria,1X10S@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_23802_3 765912.Thimo_3475 6.74e-95 285.0 28M8G@1|root,2ZAMM@2|Bacteria,1MVBT@1224|Proteobacteria,1RMAM@1236|Gammaproteobacteria,1X0EB@135613|Chromatiales 135613|Chromatiales S RES - - - - - - - - - - - - RES k59_23802_4 342113.DM82_6113 1.69e-26 103.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VQUX@28216|Betaproteobacteria,1KGZ4@119060|Burkholderiaceae 28216|Betaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_172478_1 880072.Desac_2293 9.01e-50 176.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MQ7E@213462|Syntrophobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_198141_1 1380356.JNIK01000014_gene3465 1.86e-09 56.6 2AHT8@1|root,3185S@2|Bacteria,2IMSB@201174|Actinobacteria,4EVC2@85013|Frankiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_198141_2 765912.Thimo_1841 1.19e-47 167.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1WXAB@135613|Chromatiales 135613|Chromatiales P TrkA-N domain - - - - - - - - - - - - Ion_trans_2,TrkA_N k59_36849_1 1089439.KB902240_gene863 3.07e-14 72.4 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,45ZTU@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_36849_2 1049564.TevJSym_aa01780 1.15e-29 118.0 COG1413@1|root,COG1413@2|Bacteria,1QXXK@1224|Proteobacteria,1T3JE@1236|Gammaproteobacteria,1JC18@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C lyase activity - - - - - - - - - - - - - k59_108002_1 1121937.AUHJ01000007_gene1953 7.36e-19 86.3 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_108002_2 1502770.JQMG01000001_gene1339 6.18e-13 70.1 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2VW9J@28216|Betaproteobacteria 28216|Betaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_49568_3 1049564.TevJSym_af00850 3.07e-193 543.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1J58P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2340 AIRS,AIRS_C k59_49568_5 1049564.TevJSym_af00870 2.57e-45 158.0 COG3170@1|root,COG3170@2|Bacteria,1RDXQ@1224|Proteobacteria,1T3YZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_146817_1 439235.Dalk_3419 4.32e-81 249.0 COG0467@1|root,COG0467@2|Bacteria,1R49F@1224|Proteobacteria,42P9V@68525|delta/epsilon subdivisions,2WPCD@28221|Deltaproteobacteria,2MIE8@213118|Desulfobacterales 28221|Deltaproteobacteria T Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - - - - - - - - - - AAA_25 k59_133993_2 1049564.TevJSym_ah00740 3.6e-188 531.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1J4WF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_192096_2 1049564.TevJSym_as00110 4.03e-60 192.0 2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF5063) - - - - - - - - - - - - DUF5063 k59_55532_1 1225785.CM001983_gene3011 4.88e-113 335.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,2JBTR@204037|Dickeya 1236|Gammaproteobacteria F Belongs to the CarA family carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_69239_1 614083.AWQR01000057_gene3653 3.29e-54 197.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4ADC1@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_7,PAS_9 k59_108007_1 870187.Thini_3925 2.68e-49 167.0 COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,460GH@72273|Thiotrichales 72273|Thiotrichales L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_3 k59_16607_1 765913.ThidrDRAFT_0569 1.42e-14 73.9 COG0720@1|root,COG0720@2|Bacteria,1NNVS@1224|Proteobacteria 1224|Proteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_16607_3 857087.Metme_2270 2.53e-55 190.0 COG1821@1|root,COG1821@2|Bacteria,1RBY6@1224|Proteobacteria,1SIJ0@1236|Gammaproteobacteria,1XEZB@135618|Methylococcales 135618|Methylococcales S PFAM ATP-grasp - - - - - - - - - - - - ATP-grasp_3 k59_36858_1 517418.Ctha_0919 4.24e-27 107.0 COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi 1090|Chlorobi P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_36858_2 517418.Ctha_0918 3.97e-70 219.0 COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi 1090|Chlorobi P TIGRFAM phosphate ABC transporter, inner membrane subunit PstC - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_186191_1 887898.HMPREF0551_1152 8.08e-32 130.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,1K1ZV@119060|Burkholderiaceae 28216|Betaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_134000_1 439235.Dalk_4262 1.59e-49 182.0 COG0664@1|root,COG1033@1|root,COG2199@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,COG3706@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - GGDEF,LolA_like,MMPL,cNMP_binding k59_44081_1 765912.Thimo_0329 1.32e-78 249.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_192107_1 1254432.SCE1572_25055 1.18e-65 228.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_139971_2 1166130.H650_22695 2.4e-38 144.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,3X24B@547|Enterobacter 1236|Gammaproteobacteria F DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_30054_1 1232410.KI421417_gene2808 1.11e-19 91.3 COG2801@1|root,COG2801@2|Bacteria,1NUYG@1224|Proteobacteria,42ZK0@68525|delta/epsilon subdivisions,2WUUJ@28221|Deltaproteobacteria,43URT@69541|Desulfuromonadales 28221|Deltaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_23,rve k59_11033_3 570967.JMLV01000008_gene1355 8.88e-106 314.0 COG1349@1|root,COG1349@2|Bacteria,1MUJG@1224|Proteobacteria,2TR8U@28211|Alphaproteobacteria,2JQ8B@204441|Rhodospirillales 204441|Rhodospirillales K DeoR C terminal sensor domain - - - ko:K02444 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_11033_4 1469245.JFBG01000044_gene1871 0.0 998.0 COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,1RQ8I@1236|Gammaproteobacteria,1X018@135613|Chromatiales 135613|Chromatiales G Bacterial extracellular solute-binding protein - - - ko:K17321 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - SBP_bac_1 k59_11033_5 1469245.JFBG01000044_gene1870 5.71e-142 413.0 COG3839@1|root,COG3839@2|Bacteria,1MX8G@1224|Proteobacteria,1T3B0@1236|Gammaproteobacteria,1X2WS@135613|Chromatiales 135613|Chromatiales G Belongs to the ABC transporter superfamily - - - ko:K17324 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - ABC_tran,TOBE_2 k59_11033_6 744980.TRICHSKD4_0403 1.07e-175 499.0 COG3839@1|root,COG3839@2|Bacteria,1MU7W@1224|Proteobacteria,2TQNF@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily MA20_44790 - - ko:K17325 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - ABC_tran,TOBE_2 k59_11033_7 744980.TRICHSKD4_0404 1.69e-165 467.0 COG1175@1|root,COG1175@2|Bacteria,1MVAZ@1224|Proteobacteria,2TRWF@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1175 ABC-type sugar transport systems permease components - - - ko:K17322 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - BPD_transp_1 k59_11033_8 1469245.JFBG01000044_gene1867 5.68e-166 467.0 COG0395@1|root,COG0395@2|Bacteria,1MVRG@1224|Proteobacteria,1RSNC@1236|Gammaproteobacteria,1X24V@135613|Chromatiales 135613|Chromatiales G Binding-protein-dependent transport system inner membrane component - - - ko:K17323 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - BPD_transp_1 k59_11033_9 1040983.AXAE01000011_gene3161 1.3e-25 98.2 COG5477@1|root,COG5477@2|Bacteria,1N7WT@1224|Proteobacteria,2UBTZ@28211|Alphaproteobacteria,43KN4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S small integral membrane protein - - - - - - - - - - - - DUF2160 k59_11033_10 698761.RTCIAT899_CH13185 4.48e-254 710.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,4B8DP@82115|Rhizobiaceae 28211|Alphaproteobacteria C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_11033_11 657322.FPR_13710 2.87e-40 152.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WRQU@541000|Ruminococcaceae 186801|Clostridia H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_44339_1 1121935.AQXX01000041_gene4651 1.75e-110 378.0 COG2931@1|root,COG4733@1|root,COG2931@2|Bacteria,COG4733@2|Bacteria,1PPUE@1224|Proteobacteria,1RQKW@1236|Gammaproteobacteria,1XR4B@135619|Oceanospirillales 135619|Oceanospirillales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_3808_1 582515.KR51_00035520 4.07e-83 255.0 COG0388@1|root,COG0388@2|Bacteria,1G1UJ@1117|Cyanobacteria 1117|Cyanobacteria S nitrilase - - 3.5.5.1,3.5.5.7 ko:K01501,ko:K01502 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05358,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC01336,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_3808_2 1123247.AUIJ01000022_gene276 2.41e-19 82.4 arCOG11477@1|root,32TJG@2|Bacteria,1MYXX@1224|Proteobacteria,2U9X3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_3808_3 1121918.ARWE01000001_gene3562 1.08e-27 110.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria 1224|Proteobacteria Q Methyl-transferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31,Ubie_methyltran k59_160114_3 314282.PCNPT3_03670 1.64e-87 266.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,2QJ9A@267894|Psychromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_160114_5 357804.Ping_2327 2.94e-134 398.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,2QJ72@267894|Psychromonadaceae 1236|Gammaproteobacteria P Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_147038_1 63737.Npun_F2381 5.34e-24 94.0 COG0724@1|root,COG0724@2|Bacteria,1G6TA@1117|Cyanobacteria,1HU16@1161|Nostocales 1117|Cyanobacteria S PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - - - - - - - - - - RRM_1 k59_147038_2 1121926.AXWO01000001_gene3374 1.87e-07 50.8 COG1278@1|root,COG1278@2|Bacteria,2GU26@201174|Actinobacteria 201174|Actinobacteria K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_128328_1 1049564.TevJSym_am00160 2.44e-46 165.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1J9QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_128328_2 2340.JV46_21830 2.09e-30 114.0 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1J6SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4426) PP5099 - - - - - - - - - - - DUF4426 k59_128328_3 1123354.AUDR01000018_gene1202 4.58e-14 71.2 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,1KRQF@119069|Hydrogenophilales 119069|Hydrogenophilales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_16807_1 616991.JPOO01000001_gene2807 1.06e-38 149.0 COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,4PKNJ@976|Bacteroidetes,1IJIK@117743|Flavobacteriia 976|Bacteroidetes T protein-glutamate methylesterase - - 2.1.1.80,3.1.1.61 ko:K00575,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_8,PAS_9 k59_172623_1 177437.HRM2_30480 5.98e-22 89.7 COG1664@1|root,COG1664@2|Bacteria,1QN6Q@1224|Proteobacteria,42SWT@68525|delta/epsilon subdivisions,2WPH2@28221|Deltaproteobacteria,2MK42@213118|Desulfobacterales 28221|Deltaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_172623_2 56780.SYN_02013 5.88e-52 169.0 COG1539@1|root,COG1539@2|Bacteria,1QVAP@1224|Proteobacteria,43BPU@68525|delta/epsilon subdivisions,2X712@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_101182_1 1184267.A11Q_1802 1.74e-05 48.1 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2MTEJ@213481|Bdellovibrionales,2WQIY@28221|Deltaproteobacteria 213481|Bdellovibrionales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_101182_2 1121405.dsmv_3387 3.24e-40 139.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2WPHH@28221|Deltaproteobacteria,2MJYY@213118|Desulfobacterales 28221|Deltaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_140225_1 1049564.TevJSym_au00640 6.55e-97 286.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1J4Y9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_140225_3 765910.MARPU_02810 2.64e-84 258.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales 135613|Chromatiales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_69564_1 335543.Sfum_0356 1e-124 373.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2MQ9M@213462|Syntrophobacterales 28221|Deltaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1259 ILVD_EDD k59_179580_1 1379281.AVAG01000007_gene1207 4.69e-16 72.8 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2M8QF@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_140226_1 706587.Desti_0073 2.11e-65 207.0 COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,42UXR@68525|delta/epsilon subdivisions,2WQCT@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_186430_1 1410620.SHLA_44c000310 9.77e-08 57.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2U6SH@28211|Alphaproteobacteria,4BKKS@82115|Rhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_4,TetR_N k59_160117_2 1049564.TevJSym_af00760 6.84e-86 257.0 COG2143@1|root,COG2143@2|Bacteria,1RB3S@1224|Proteobacteria,1S2A7@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like - - - - - - - - - - - - Thioredoxin_2 k59_69565_1 136084.Q9G0G5_9CAUD 2.98e-64 215.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_134180_1 1121413.JMKT01000008_gene1106 6.77e-46 166.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WPR9@28221|Deltaproteobacteria,2M7TV@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD k59_134180_2 43989.cce_3486 1.61e-34 127.0 COG2020@1|root,COG2020@2|Bacteria,1G5RJ@1117|Cyanobacteria 1117|Cyanobacteria O Protein of unknown function (DUF1295) - - - - - - - - - - - - PEMT k59_134180_3 1120966.AUBU01000003_gene1537 2.5e-16 76.3 COG2329@1|root,COG2329@2|Bacteria,4NS8X@976|Bacteroidetes,47RR3@768503|Cytophagia 976|Bacteroidetes S involved in biosynthesis of extracellular polysaccharides - - - - - - - - - - - - ABM k59_134180_4 697282.Mettu_2748 1.23e-36 127.0 2CJ4Q@1|root,32S97@2|Bacteria,1N0B9@1224|Proteobacteria,1S97T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ethyl tert-butyl ether degradation ethD - - - - - - - - - - - EthD k59_75279_3 2340.JV46_25840 1.08e-48 171.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_172626_1 1123355.JHYO01000031_gene1595 5.74e-82 258.0 COG0583@1|root,COG0583@2|Bacteria,1MX53@1224|Proteobacteria,2TTGX@28211|Alphaproteobacteria,370YB@31993|Methylocystaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_69567_1 933262.AXAM01000033_gene1642 2.05e-107 330.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 k59_198350_1 1380391.JIAS01000013_gene3781 9.33e-73 249.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JUYT@204441|Rhodospirillales 204441|Rhodospirillales S Alpha-2-Macroglobulin - - - - - - - - - - - - A2M,A2M_N,A2M_N_2 k59_128338_1 886293.Sinac_7016 5.01e-78 249.0 COG3344@1|root,COG3344@2|Bacteria,2IZ3V@203682|Planctomycetes 203682|Planctomycetes L reverse transcriptase - - - - - - - - - - - - RVT_1 k59_63028_1 1049564.TevJSym_bm00130 1.98e-261 732.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1J4GN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_69570_1 5297.GMQ_19917T0 9.34e-48 174.0 COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3NW85@4751|Fungi,3UXW6@5204|Basidiomycota,2YCQK@29000|Pucciniomycotina 4751|Fungi F Carbamoyl-phosphate synthase small chain, CPSase domain URA2 GO:0000050,GO:0003674,GO:0003824,GO:0003922,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006142,GO:0006206,GO:0006207,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009892,GO:0009987,GO:0016020,GO:0016021,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019219,GO:0019222,GO:0019627,GO:0019752,GO:0019856,GO:0031224,GO:0031323,GO:0031324,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045934,GO:0045984,GO:0046112,GO:0046394,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0055086,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0080090,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.2,6.3.5.5 ko:K01954,ko:K11541 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R01397,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC02750,RC02798,RC02850,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N k59_160123_1 331678.Cphamn1_0629 1.63e-53 181.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1FD5R@1090|Chlorobi 1090|Chlorobi H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_160123_2 56780.SYN_02372 2.77e-08 52.8 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2MQEK@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_55756_1 485913.Krac_7449 1.91e-71 237.0 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_205163_2 94624.Bpet4408 1.55e-18 86.3 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,2VJIH@28216|Betaproteobacteria,3T7Z7@506|Alcaligenaceae 28216|Betaproteobacteria S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_166201_1 1499967.BAYZ01000028_gene1307 2.11e-132 386.0 COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria 2|Bacteria U Branched-chain amino acid transport system / permease component livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_166201_2 1499967.BAYZ01000028_gene1308 3.13e-134 385.0 COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid ATP-binding cassette transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_16813_2 1120792.JAFV01000001_gene1101 2.68e-54 181.0 COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,2U80I@28211|Alphaproteobacteria,3708N@31993|Methylocystaceae 28211|Alphaproteobacteria S Histidine biosynthesis protein - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_117608_1 94624.Bpet0216 9.07e-20 84.3 COG3415@1|root,COG3415@2|Bacteria,1RFNA@1224|Proteobacteria,2WGVM@28216|Betaproteobacteria,3T7U2@506|Alcaligenaceae 1224|Proteobacteria L Transposase - - - - - - - - - - - - HTH_23,HTH_Tnp_1 k59_195201_1 1121405.dsmv_0058 2.73e-65 212.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42MWF@68525|delta/epsilon subdivisions,2WKAQ@28221|Deltaproteobacteria,2MIMD@213118|Desulfobacterales 28221|Deltaproteobacteria M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_124065_1 96561.Dole_0650 2.44e-113 350.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,42NCP@68525|delta/epsilon subdivisions,2WJSM@28221|Deltaproteobacteria,2MI5K@213118|Desulfobacterales 28221|Deltaproteobacteria M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_26886_2 177437.HRM2_32610 2.25e-06 49.7 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2MI4N@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_175861_1 1408444.JHYC01000003_gene660 6.6e-49 156.0 COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,1S99Z@1236|Gammaproteobacteria,1JF4A@118969|Legionellales 118969|Legionellales S YoeB-like toxin of bacterial type II toxin-antitoxin system yoeB - - ko:K19158 - - - - ko00000,ko01000,ko02048 - - - YoeB_toxin k59_175861_2 1380387.JADM01000023_gene1815 1.81e-20 82.8 COG2161@1|root,COG2161@2|Bacteria,1N6X6@1224|Proteobacteria,1SDQ0@1236|Gammaproteobacteria,1XPNR@135619|Oceanospirillales 135619|Oceanospirillales D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox k59_124066_1 1232410.KI421425_gene1546 1.2e-61 196.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales 28221|Deltaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_143489_1 663321.REG_1916 8.72e-41 137.0 COG3657@1|root,COG3657@2|Bacteria,1N74C@1224|Proteobacteria,1SCNC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S addiction module killer protein - - - - - - - - - - - - Gp49 k59_143489_2 291112.PAU_01619 1.92e-55 174.0 COG3636@1|root,COG3636@2|Bacteria,1N1JW@1224|Proteobacteria,1S97N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K addiction module antidote protein - - - - - - - - - - - - - k59_156457_1 768671.ThimaDRAFT_2343 2.25e-61 202.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_156457_2 1049564.TevJSym_ak00140 3.52e-122 362.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1J6JM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_156457_3 1049564.TevJSym_ak00150 2.56e-110 345.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_91813_2 1117319.PSPO_00792 4.13e-27 122.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_33491_1 439235.Dalk_3310 4.92e-86 265.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2MHY8@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_202147_1 1122194.AUHU01000003_gene2289 9.22e-21 87.4 COG3518@1|root,COG3518@2|Bacteria,1RG8W@1224|Proteobacteria,1S50E@1236|Gammaproteobacteria,4697Z@72275|Alteromonadaceae 1236|Gammaproteobacteria S Gene 25-like lysozyme - - - ko:K11897 - M00334 - - ko00000,ko00002,ko02044 - - - GPW_gp25 k59_202147_2 377629.TERTU_1651 3.96e-55 189.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,1RPK4@1236|Gammaproteobacteria,2PPQX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Pfam:T6SS_VipB vasA - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_111331_2 177437.HRM2_10310 7.64e-66 214.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2MI6E@213118|Desulfobacterales 28221|Deltaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_79103_1 1238182.C882_4461 1.44e-46 154.0 2B047@1|root,31SEM@2|Bacteria,1RHZY@1224|Proteobacteria,2UB51@28211|Alphaproteobacteria,2JT9B@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_182715_1 114615.BRADO2379 1e-26 100.0 COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2UET5@28211|Alphaproteobacteria,3JYU1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_182715_2 469381.Dpep_2383 4.47e-09 59.3 COG5001@1|root,COG5001@2|Bacteria,3TAJ9@508458|Synergistetes 508458|Synergistetes T GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,sCache_2 k59_79105_1 1049564.TevJSym_ad00500 5.24e-173 500.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter phaD - 1.6.5.3 ko:K00342,ko:K05561,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_124289_2 97139.C824_00307 5.28e-144 416.0 COG1192@1|root,COG1192@2|Bacteria,1VHM0@1239|Firmicutes,24FNK@186801|Clostridia,36QX2@31979|Clostridiaceae 186801|Clostridia D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_124289_3 1121285.AUFK01000018_gene748 2.98e-12 62.0 2EHXM@1|root,33BP4@2|Bacteria,4PGND@976|Bacteroidetes,1IHFD@117743|Flavobacteriia,3ZU54@59732|Chryseobacterium 976|Bacteroidetes S Protein of unknown function (DUF3606) - - - - - - - - - - - - DUF3606 k59_39984_1 1049564.TevJSym_ao00790 3.29e-235 657.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1J4IG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_39984_2 765912.Thimo_2787 3.03e-48 167.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_189139_1 926556.Echvi_2421 2.97e-19 89.0 COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,47JZG@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c k59_189139_2 589865.DaAHT2_0407 1.45e-11 65.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_65849_3 1173025.GEI7407_3297 6.88e-97 288.0 COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales 1117|Cyanobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_143746_1 335543.Sfum_2075 3.92e-156 453.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_137132_1 1049564.TevJSym_aj00410 4.99e-39 143.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1J51W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1032 Fe-S oxidoreductase ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_27062_1 1166948.JPZL01000003_gene619 1.76e-260 735.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1XHJ2@135619|Oceanospirillales 135619|Oceanospirillales C Domain of unknown function (DUF3483) - - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_27062_2 1122139.KB907862_gene795 7.8e-108 331.0 COG2025@1|root,COG2025@2|Bacteria,1MUQ5@1224|Proteobacteria,1RS2R@1236|Gammaproteobacteria,1XHQV@135619|Oceanospirillales 135619|Oceanospirillales C Electron transfer flavoprotein, alpha subunit - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_27062_3 1112217.PPL19_09436 6.22e-71 225.0 COG2086@1|root,COG2086@2|Bacteria,1N8JA@1224|Proteobacteria,1RP9A@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Electron transfer flavoprotein etfB-1 - - ko:K03521 - - - - ko00000 - - - ETF k59_65850_1 313628.LNTAR_25330 6.24e-30 119.0 COG1349@1|root,COG1349@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - 3.6.4.12 ko:K02444,ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - AlbA_2,DUF1670,DeoRC,HATPase_c_4,HTH_DeoR k59_195332_1 1163389.OOM_1620 0.000235 50.1 COG1087@1|root,COG1087@2|Bacteria,1QX2P@1224|Proteobacteria 1224|Proteobacteria M Nad-dependent epimerase dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_7645_1 247490.KSU1_D0400 2.75e-13 76.3 COG2204@1|root,COG2204@2|Bacteria 247490.KSU1_D0400|- T phosphorelay signal transduction system - - - - - - - - - - - - - k59_163144_1 1262449.CP6013_2827 1.06e-32 125.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae 186801|Clostridia K aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_163144_2 572477.Alvin_0557 0.0 1267.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJE@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_163144_3 1151116.Q7S_07840 2.44e-15 84.7 COG0845@1|root,COG0845@2|Bacteria,1PVWV@1224|Proteobacteria,1RMYG@1236|Gammaproteobacteria,3FFVQ@34037|Rahnella 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_52969_1 1049564.TevJSym_bt00100 3.97e-27 108.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria,1JBVR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain VPA0559 - - - - - - - - - - - FtsX,MacB_PCD k59_52969_2 1049564.TevJSym_bt00090 2.24e-62 204.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria,1JBVR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain VPA0559 - - - - - - - - - - - FtsX,MacB_PCD k59_202153_1 1121939.L861_08745 3.37e-44 159.0 COG4961@1|root,COG4961@2|Bacteria 2|Bacteria U PFAM TadE family protein - - - - - - - - - - - - Tad,Tad_C k59_202153_2 1169143.KB911053_gene2690 1.82e-07 55.1 COG4961@1|root,COG4961@2|Bacteria,1N247@1224|Proteobacteria,2VVE5@28216|Betaproteobacteria,1K8V9@119060|Burkholderiaceae 28216|Betaproteobacteria U PFAM TadE family protein tadG1 - - - - - - - - - - - TadE k59_91833_1 471855.Shel_24870 6.98e-08 58.9 COG0726@1|root,COG3291@1|root,COG0726@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - DUF5011,Polysacc_deac_1 k59_20507_1 1198114.AciX9_2245 7.1e-16 74.7 COG2963@1|root,COG2963@2|Bacteria,3Y86J@57723|Acidobacteria,2JN6K@204432|Acidobacteriia 204432|Acidobacteriia L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_20507_2 714943.Mucpa_5701 1.28e-21 93.2 COG2801@1|root,COG2801@2|Bacteria,4NIBY@976|Bacteroidetes,1ITSB@117747|Sphingobacteriia 976|Bacteroidetes L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_79108_1 754477.Q7C_257 3.43e-34 134.0 COG4585@1|root,COG4585@2|Bacteria,1RHF6@1224|Proteobacteria,1S8ER@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,LapD_MoxY_N k59_7650_1 335543.Sfum_1219 2.15e-54 181.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MQW6@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_169738_1 1047013.AQSP01000113_gene754 6.74e-67 223.0 COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria 2|Bacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_20508_1 1049564.TevJSym_ab00250 1.29e-56 188.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_20508_2 944546.ABED_0581 8.2e-70 232.0 COG4206@1|root,COG4206@2|Bacteria,1QUPS@1224|Proteobacteria,43CID@68525|delta/epsilon subdivisions,2YTCZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_46429_1 880072.Desac_1077 1.4e-141 412.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,42NJ3@68525|delta/epsilon subdivisions,2WKHX@28221|Deltaproteobacteria,2MQTA@213462|Syntrophobacterales 28221|Deltaproteobacteria O Uncharacterized protein family (UPF0051) - - - ko:K07033 - - - - ko00000 - - - UPF0051 k59_59477_3 1049564.TevJSym_bc00320 4.99e-39 134.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_72367_2 1121035.AUCH01000007_gene601 2.33e-50 169.0 COG2346@1|root,COG2346@2|Bacteria,1N1UU@1224|Proteobacteria,2VZUZ@28216|Betaproteobacteria 28216|Betaproteobacteria S COG2346, Truncated hemoglobins - - - - - - - - - - - - - k59_72367_5 883169.HMPREF9719_00307 4.37e-05 55.1 2DUUJ@1|root,33SC8@2|Bacteria,2I78V@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_72367_8 1128427.KB904821_gene4630 1.98e-06 60.1 COG0811@1|root,COG0811@2|Bacteria,1FZW7@1117|Cyanobacteria,1HF2W@1150|Oscillatoriales 1117|Cyanobacteria U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_72367_9 316274.Haur_0717 9.25e-30 136.0 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,2G5NM@200795|Chloroflexi,3755B@32061|Chloroflexia 200795|Chloroflexi KLT Serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_72367_10 1131269.AQVV01000001_gene1469 1.84e-20 106.0 COG0457@1|root,COG1262@1|root,COG0457@2|Bacteria,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - FGE-sulfatase,Pkinase k59_72367_14 1218352.B597_016375 1.63e-83 263.0 COG3239@1|root,COG3239@2|Bacteria,1P79B@1224|Proteobacteria,1RNY0@1236|Gammaproteobacteria,1Z2KI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_98187_1 401526.TcarDRAFT_2056 1.35e-36 140.0 COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,4H1VJ@909932|Negativicutes 909932|Negativicutes H Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_98187_2 335543.Sfum_0418 1.41e-67 209.0 COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2MQHM@213462|Syntrophobacterales 28221|Deltaproteobacteria S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_98187_3 880072.Desac_0856 4.83e-85 258.0 COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2MRJE@213462|Syntrophobacterales 28221|Deltaproteobacteria E DNA polymerase alpha chain like domain - - - - - - - - - - - - PHP k59_143766_1 1382356.JQMP01000004_gene488 1.23e-207 589.0 COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia 189775|Thermomicrobia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_202162_1 1280953.HOC_17876 4.11e-06 48.9 COG4575@1|root,COG4575@2|Bacteria,1NGZU@1224|Proteobacteria,2V708@28211|Alphaproteobacteria,43YSH@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF883) - - - - - - - - - - - - DUF883 k59_137229_3 768671.ThimaDRAFT_1995 1.42e-22 91.3 COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,1T4CE@1236|Gammaproteobacteria,1X1B8@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_137229_4 298386.PBPRA3572 9.68e-162 459.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XT68@135623|Vibrionales 135623|Vibrionales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_33648_1 519989.ECTPHS_12515 1.33e-97 303.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_27216_1 589924.Ferp_0912 2.57e-56 187.0 COG1180@1|root,arCOG00946@2157|Archaea 2157|Archaea C PFAM Radical SAM domain protein - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_202285_1 84531.JMTZ01000095_gene438 7.42e-14 70.9 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales 135614|Xanthomonadales L Helicase lhr1 - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_104865_1 251221.35210932 2.08e-61 206.0 COG3385@1|root,COG3385@2|Bacteria,1G3D9@1117|Cyanobacteria 1117|Cyanobacteria L Transposase DNA-binding - - - - - - - - - - - - DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_164398_2 1100720.ALKN01000045_gene283 5.96e-08 57.4 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,2VVPQ@28216|Betaproteobacteria,4AFBC@80864|Comamonadaceae 28216|Betaproteobacteria NU Pilus assembly protein fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_164398_3 1049564.TevJSym_am00350 7.75e-11 61.2 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,1J75A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU type IV pilus modification protein PilV pilV - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_73492_1 207559.Dde_1185 9.88e-91 283.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N16@68525|delta/epsilon subdivisions,2X73Y@28221|Deltaproteobacteria,2MBUH@213115|Desulfovibrionales 28221|Deltaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle dppA - - ko:K02035,ko:K12368 ko02010,ko02024,ko02030,map02010,map02024,map02030 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_2116_1 768671.ThimaDRAFT_4897 3.18e-34 130.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,1RRFT@1236|Gammaproteobacteria,1WZIC@135613|Chromatiales 135613|Chromatiales L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_80446_1 96561.Dole_2174 1.86e-77 245.0 COG2199@1|root,COG3437@1|root,COG3437@2|Bacteria,COG3706@2|Bacteria,1NTDW@1224|Proteobacteria,42N8P@68525|delta/epsilon subdivisions,2WKW9@28221|Deltaproteobacteria,2MIEQ@213118|Desulfobacterales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - HD,HD_5,Response_reg k59_67202_1 933262.AXAM01000039_gene1157 3.3e-44 159.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,43BS1@68525|delta/epsilon subdivisions,2X72V@28221|Deltaproteobacteria,2MPJD@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_106057_1 258594.RPA4424 1.56e-83 258.0 COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria,3JSGW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_106057_2 1128421.JAGA01000002_gene1359 9.2e-43 160.0 COG0520@1|root,COG0520@2|Bacteria,2NP4B@2323|unclassified Bacteria 2|Bacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_5 k59_106057_4 160799.PBOR_19450 3.53e-45 189.0 COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4HFCI@91061|Bacilli,2771J@186822|Paenibacillaceae 91061|Bacilli Q Polyketide synthase modules and related proteins - - - ko:K13612,ko:K13614 - - - - ko00000,ko01004,ko01008 - - - KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_93526_3 768671.ThimaDRAFT_3286 5.12e-07 58.9 COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,1SYJF@1236|Gammaproteobacteria,1WXTI@135613|Chromatiales 135613|Chromatiales S PFAM Ankyrin - - - - - - - - - - - - Ank_2,Ank_4,Ank_5 k59_73495_1 1291050.JAGE01000001_gene1385 4.63e-22 100.0 COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,3WI2J@541000|Ruminococcaceae 186801|Clostridia C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_14986_1 1255043.TVNIR_0152 9.19e-84 270.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales 135613|Chromatiales L DEAD DEAH box - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_203398_1 1049564.TevJSym_at00020 2.64e-137 391.0 COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,1RNZ8@1236|Gammaproteobacteria,1J9CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_203398_2 1049564.TevJSym_at00040 3.82e-216 601.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1J4IA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_22130_2 1049564.TevJSym_bt00080 1.8e-90 275.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria 1224|Proteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_119469_1 573569.F7308_1185 5.38e-76 245.0 COG3719@1|root,COG3719@2|Bacteria,1NRPM@1224|Proteobacteria,1RND8@1236|Gammaproteobacteria,462N0@72273|Thiotrichales 72273|Thiotrichales J Ribonuclease T2 family - - 3.1.27.1 ko:K01166 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_T2 k59_119469_2 1123355.JHYO01000027_gene2045 3.89e-128 390.0 COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,36XJA@31993|Methylocystaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9 k59_93534_1 1121405.dsmv_2622 7e-65 212.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42PZ6@68525|delta/epsilon subdivisions,2WKNQ@28221|Deltaproteobacteria,2MI1H@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid kinase family - - 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_112696_1 1123400.KB904795_gene1974 1.39e-40 151.0 COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria,1S2JX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_119472_1 396588.Tgr7_1852 4.21e-69 218.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1WW7E@135613|Chromatiales 135613|Chromatiales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_125885_1 880072.Desac_0501 9.42e-92 293.0 COG2202@1|root,COG2204@1|root,COG3290@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_93540_2 1121405.dsmv_0193 1.89e-23 94.4 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MK72@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_41711_4 498211.CJA_2502 7.7e-87 323.0 COG3210@1|root,COG3210@2|Bacteria,1QQD4@1224|Proteobacteria,1RZ1D@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Mandelate Racemase Muconate Lactonizing - - - - - - - - - - - - - k59_99390_2 298386.PBPRA1288 8.44e-42 142.0 2AWPR@1|root,31NKN@2|Bacteria,1QKBC@1224|Proteobacteria,1TIEU@1236|Gammaproteobacteria,1XZ07@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_151701_1 290317.Cpha266_2339 1.32e-58 194.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_15000_2 1449338.JQLU01000005_gene1650 5.46e-20 96.3 COG3845@1|root,COG3845@2|Bacteria,1UI2B@1239|Firmicutes,4ISBR@91061|Bacilli 91061|Bacilli P COG1122 ABC-type cobalt transport system, ATPase component - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran,CbiQ k59_171277_1 1121012.AUKX01000002_gene3413 2.22e-113 336.0 COG2801@1|root,COG2801@2|Bacteria,4NHJD@976|Bacteroidetes,1IABF@117743|Flavobacteriia 976|Bacteroidetes L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_29,rve,rve_3 k59_35019_1 1121090.KB894720_gene1908 1.59e-108 338.0 COG1061@1|root,COG1199@1|root,COG1061@2|Bacteria,COG1199@2|Bacteria,1URXJ@1239|Firmicutes,4HF1N@91061|Bacilli,1ZG9U@1386|Bacillus 91061|Bacilli L HELICc2 - - - - - - - - - - - - Helicase_C_2,ResIII k59_177670_1 1049564.TevJSym_ae00030 9.29e-160 478.0 COG0358@1|root,COG0358@2|Bacteria,1MWQW@1224|Proteobacteria 1224|Proteobacteria L Toprim domain - - - - - - - - - - - - Toprim_3 k59_54102_1 1265313.HRUBRA_00107 6.53e-25 103.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_54102_2 864051.BurJ1DRAFT_3137 1.42e-17 97.1 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria,1KNGG@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_54102_3 1049564.TevJSym_ak00330 1.22e-196 559.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1JBHG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - - - - - - - - - - ArsB,CitMHS k59_54102_4 1049564.TevJSym_ak00320 2.38e-52 170.0 2FHYC@1|root,349RC@2|Bacteria,1P31R@1224|Proteobacteria,1SRZR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_54102_5 1049564.TevJSym_ak00310 1.2e-24 98.2 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1J5CU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_60874_1 1411123.JQNH01000001_gene2890 2.03e-14 82.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,2TUGQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria OU periplasmic serine proteases (ClpP class) - - - - - - - - - - - - Peptidase_S49 k59_203414_1 1479235.KK366039_gene860 1.56e-95 303.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XIHW@135619|Oceanospirillales 135619|Oceanospirillales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom k59_15002_1 933262.AXAM01000013_gene1324 6.9e-19 90.1 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_164420_1 1117315.AHCA01000011_gene1450 7.51e-10 65.9 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2Q0AU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T Aerobic respiration control sensor protein arcB - 2.7.13.3 ko:K07648 ko02020,ko02026,map02020,map02026 M00456 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg k59_157987_2 258594.RPA2578 1.34e-29 127.0 COG0457@1|root,COG0457@2|Bacteria,1RIYN@1224|Proteobacteria,2UK8N@28211|Alphaproteobacteria,3K544@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S SGNH hydrolase-like domain, acetyltransferase AlgX - - - - - - - - - - - - ALGX k59_157987_3 596151.DesfrDRAFT_1712 1.81e-151 446.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WJ85@28221|Deltaproteobacteria,2M8UI@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM membrane bound O-acyl transferase MBOAT - - - ko:K19294 - - - - ko00000 - - - MBOAT k59_2143_1 396588.Tgr7_0375 1.55e-45 164.0 COG1538@1|root,COG1538@2|Bacteria,1RDNB@1224|Proteobacteria,1S535@1236|Gammaproteobacteria,1WXQ5@135613|Chromatiales 135613|Chromatiales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_35022_1 177437.HRM2_22100 1.49e-57 202.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_119489_1 1123489.AUAN01000002_gene741 3.39e-30 119.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4H2VA@909932|Negativicutes 909932|Negativicutes J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_60878_1 1123401.JHYQ01000014_gene855 1.24e-37 137.0 COG4305@1|root,COG4305@2|Bacteria,1MYW4@1224|Proteobacteria,1T01P@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - ko:K20628 - - - - ko00000 - - - Cellulase,DPBB_1 k59_93559_1 868595.Desca_2271 5.49e-34 134.0 COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25ZYA@186807|Peptococcaceae 186801|Clostridia L TIGRFAM single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1,Helicase_C k59_54107_1 1499967.BAYZ01000154_gene1471 2.06e-12 67.8 COG0406@1|root,COG0406@2|Bacteria,2NQ0Y@2323|unclassified Bacteria 2|Bacteria G Phosphoglycerate mutase family - - 3.1.3.73,5.4.2.12 ko:K02226,ko:K15634 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00122 R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000 - - - 6PF2K,His_Phos_1 k59_9175_1 706587.Desti_3107 5.87e-16 73.6 2EQZT@1|root,33IJD@2|Bacteria,1NKTX@1224|Proteobacteria,42XNG@68525|delta/epsilon subdivisions,2WTCK@28221|Deltaproteobacteria,2MQPM@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_9175_2 880072.Desac_1681 2.49e-96 291.0 COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria 1224|Proteobacteria J Methionyl-tRNA formyltransferase - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_119630_1 1173023.KE650771_gene3178 1.83e-18 79.7 COG3654@1|root,COG3654@2|Bacteria,1G781@1117|Cyanobacteria,1JJ3W@1189|Stigonemataceae 1117|Cyanobacteria S Fic/DOC family - - - ko:K07341 - - - - ko00000,ko02048 - - - Fic k59_119630_2 237368.SCABRO_00708 2.28e-89 264.0 COG1671@1|root,COG1671@2|Bacteria,2IZRB@203682|Planctomycetes 203682|Planctomycetes S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_73604_1 1121935.AQXX01000055_gene2904 5.47e-250 694.0 COG0507@1|root,COG3843@1|root,COG0507@2|Bacteria,COG3843@2|Bacteria,1MUTR@1224|Proteobacteria,1RQS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L MobA/MobL family - - - - - - - - - - - - MobA_MobL k59_73604_3 323850.Shew_0988 0.0 1038.0 COG0697@1|root,COG0697@2|Bacteria,1RE9G@1224|Proteobacteria,1S6YW@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG spore germination - - - - - - - - - - - - - k59_145419_1 177437.HRM2_46510 2.3e-70 217.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,42QRQ@68525|delta/epsilon subdivisions,2WMRU@28221|Deltaproteobacteria,2MJP2@213118|Desulfobacterales 28221|Deltaproteobacteria Q TIGRFAM methionine biosynthesis protein MetW - - - - - - - - - - - - MetW k59_145419_2 1322246.BN4_11777 3.33e-14 71.6 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2WJRJ@28221|Deltaproteobacteria,2M965@213115|Desulfovibrionales 28221|Deltaproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Homoserine_dh,NAD_binding_3 k59_184487_1 1307761.L21SP2_2654 1.3e-23 102.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_177785_1 1049564.TevJSym_ac01490 1.41e-93 278.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1J6BV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DSBA-like thioredoxin domain dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_35172_1 335543.Sfum_0771 2.55e-45 150.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2WP5B@28221|Deltaproteobacteria,2MQHT@213462|Syntrophobacterales 28221|Deltaproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_86843_1 158500.BV97_05755 1.49e-76 246.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_93734_1 156889.Mmc1_2502 1.06e-72 224.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2U2IN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C hydrogenase expression formation protein - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_93734_2 1187851.A33M_3096 7.48e-21 86.7 COG0298@1|root,COG0298@2|Bacteria,1N9Z3@1224|Proteobacteria,2UD5V@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Hydrogenase expression formation protein hupF hupF - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_93734_3 1188256.BASI01000005_gene2131 2.74e-23 98.2 COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2U0HG@28211|Alphaproteobacteria,3FEGD@34008|Rhodovulum 28211|Alphaproteobacteria C [NiFe]-hydrogenase assembly, chaperone, HybE hupJ - - - - - - - - - - - NiFe-hyd_HybE,Rubredoxin k59_196705_1 1121405.dsmv_3411 2.48e-12 68.2 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2MHKD@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_196705_2 56780.SYN_01739 1.55e-27 114.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2MQXI@213462|Syntrophobacterales 28221|Deltaproteobacteria M Penicillin-binding Protein dimerisation domain ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_151826_1 768671.ThimaDRAFT_0549 1.82e-219 622.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_99511_2 933262.AXAM01000062_gene952 3.47e-52 175.0 COG0394@1|root,COG0655@1|root,COG0394@2|Bacteria,COG0655@2|Bacteria,1NANP@1224|Proteobacteria,42Q16@68525|delta/epsilon subdivisions,2WIJ7@28221|Deltaproteobacteria,2MIC1@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red,LMWPc k59_203546_1 338963.Pcar_2495 1.12e-18 85.5 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,43UBA@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_47964_1 439235.Dalk_2056 2.95e-81 254.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,42SS9@68525|delta/epsilon subdivisions,2WPND@28221|Deltaproteobacteria,2MK6P@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM Alpha beta hydrolase fold-3 domain protein - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_119634_2 1121943.KB899992_gene2295 4e-122 360.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1XIB9@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_185389_1 1049564.TevJSym_an00290 1.08e-114 332.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1J4HC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_185389_2 1249627.D779_1436 9.83e-38 136.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales 135613|Chromatiales J Elongation factor P--(R)-beta-lysine ligase - - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_120645_5 1122135.KB893135_gene992 3.11e-40 140.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2TVFG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Lysine exporter protein (LYSE YGGA) - - - - - - - - - - - - LysE k59_23063_1 1396858.Q666_11855 1.25e-127 369.0 2DZ3G@1|root,32V6J@2|Bacteria,1N2Y8@1224|Proteobacteria,1S9EE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_127376_1 1121405.dsmv_3490 1.56e-78 243.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria,2MIMY@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2495 GATase,Glycos_trans_3N,Glycos_transf_3 k59_159108_1 439235.Dalk_2209 2.45e-76 240.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42NUP@68525|delta/epsilon subdivisions,2WKSD@28221|Deltaproteobacteria,2MNKG@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-1 - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_100401_1 1049564.TevJSym_aa01890 2.37e-133 391.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_43503_1 1049564.TevJSym_av00360 1.17e-39 149.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU general secretion pathway protein D xcsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_165606_1 1049564.TevJSym_ad01170 2.48e-146 440.0 COG5148@1|root,COG5148@2|Bacteria,1QTZE@1224|Proteobacteria,1RY3H@1236|Gammaproteobacteria,1J5W5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_139508_1 1500259.JQLD01000006_gene951 6.57e-17 81.6 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TS4B@28211|Alphaproteobacteria,4B8WV@82115|Rhizobiaceae 28211|Alphaproteobacteria S cobalamin synthesis protein p47K - - - - - - - - - - - CobW_C,cobW k59_139508_2 1265505.ATUG01000002_gene1094 1.68e-35 127.0 COG5423@1|root,COG5423@2|Bacteria,1N9C0@1224|Proteobacteria,42W42@68525|delta/epsilon subdivisions,2WR81@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284 k59_113856_1 1049564.TevJSym_ag00260 1.5e-93 280.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1J8TI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q ABC transporter mlaF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_113856_2 228410.NE1874 1.87e-43 144.0 COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,373AC@32003|Nitrosomonadales 28216|Betaproteobacteria C Ferredoxin fdx - - - - - - - - - - - 2Fe-2S_thioredx k59_113856_3 1049564.TevJSym_ag00300 4.96e-117 353.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1J56B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 k59_178978_1 1071073.KI530536_gene958 7.29e-55 187.0 COG3119@1|root,COG3119@2|Bacteria,1VAJC@1239|Firmicutes,4HGBS@91061|Bacilli,1ZGU6@1386|Bacillus 91061|Bacilli P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_159394_1 933262.AXAM01000009_gene1492 8.39e-62 203.0 COG1150@1|root,COG1150@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam k59_100601_1 883.DvMF_0705 5.73e-49 176.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MG9J@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_120985_1 1123504.JQKD01000021_gene5736 3.16e-103 305.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VIDM@28216|Betaproteobacteria,4AAPG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Amidohydrolase 2 - - 3.1.1.57 ko:K10221 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R04277 RC03110 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_120985_2 935863.AWZR01000001_gene1907 4.85e-76 228.0 COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,1S8CE@1236|Gammaproteobacteria,1XAYW@135614|Xanthomonadales 135614|Xanthomonadales S Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - - - - - - - - - - LigA k59_49152_1 1232437.KL661986_gene3654 2.23e-26 105.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_87940_1 555779.Dthio_PD1010 1.98e-58 193.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2M7X4@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam k59_87940_2 768704.Desmer_0628 8.34e-47 159.0 2CDHP@1|root,32RXU@2|Bacteria,1VQ7W@1239|Firmicutes,251NF@186801|Clostridia,265N8@186807|Peptococcaceae 186801|Clostridia S RsbT co-antagonist protein rsbRD N-terminal domain - - - - - - - - - - - - RsbRD_N k59_68768_1 1121022.ABENE_04845 3.06e-99 304.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_5 k59_29599_2 589865.DaAHT2_1468 2.49e-55 186.0 COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam k59_152718_1 1273711.A0A096VKG4_9CAUD 1.18e-14 80.9 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_10371_1 1227487.C474_04610 2.61e-61 198.0 COG1226@1|root,arCOG01964@2157|Archaea,2XW00@28890|Euryarchaeota,23TV4@183963|Halobacteria 183963|Halobacteria P COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_68777_1 429009.Adeg_0177 2.25e-49 180.0 COG1067@1|root,COG1674@1|root,COG1067@2|Bacteria,COG1674@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,42FSR@68295|Thermoanaerobacterales 186801|Clostridia O Endopeptidase La - - 3.4.21.53 ko:K04076 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_204607_1 1232437.KL662014_gene1324 1.2e-89 275.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MICP@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_95268_1 1049564.TevJSym_ap00500 3.27e-191 541.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH ubiquinone oxidoreductase subunit nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_95268_2 1268622.AVS7_00499 1.73e-14 73.6 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,4A9X6@80864|Comamonadaceae 28216|Betaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_29605_1 243231.GSU1722 1.71e-10 60.8 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WMNK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_29605_2 237368.SCABRO_02673 2.22e-32 127.0 COG0826@1|root,COG0826@2|Bacteria,2IYDC@203682|Planctomycetes 203682|Planctomycetes O Collagenase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_165612_1 929712.KI912613_gene1134 8.81e-34 132.0 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CQ6E@84995|Rubrobacteria 84995|Rubrobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_165612_2 1049564.TevJSym_ch00060 5.5e-95 286.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1J675@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_165612_3 948565.AFFP02000004_gene761 7.01e-06 46.6 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1Y7T1@135625|Pasteurellales 135625|Pasteurellales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_95269_2 1423807.BACO01000036_gene1033 3.38e-12 67.4 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,3FC7D@33958|Lactobacillaceae 91061|Bacilli I Enoyl-CoA hydratase/isomerase crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_81766_1 688269.Theth_1983 3.7e-41 148.0 COG0601@1|root,COG0601@2|Bacteria,2GCPY@200918|Thermotogae 200918|Thermotogae P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_49158_2 1157490.EL26_21520 4.61e-65 215.0 COG4974@1|root,COG4974@2|Bacteria,1TQ3R@1239|Firmicutes,4HD6N@91061|Bacilli,278SR@186823|Alicyclobacillaceae 91061|Bacilli L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_100608_2 768671.ThimaDRAFT_0539 3.04e-90 276.0 2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,1RYMW@1236|Gammaproteobacteria,1WWWK@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_23362_1 207559.Dde_1184 4.52e-151 434.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria,2MG57@213115|Desulfovibrionales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component dppB - - ko:K02033,ko:K12369 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_62374_1 247490.KSU1_D0158 2.19e-102 312.0 COG3666@1|root,COG3666@2|Bacteria,2J1Y1@203682|Planctomycetes 203682|Planctomycetes L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_113872_1 1232683.ADIMK_4172 4.81e-143 420.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,4656N@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_146516_2 1303518.CCALI_00985 1.02e-28 117.0 COG1480@1|root,COG1480@2|Bacteria 2|Bacteria O 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_197778_1 1049564.TevJSym_ag00870 2.36e-98 293.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,1RQT5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_197778_2 287.DR97_1072 5.72e-53 169.0 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1S5YX@1236|Gammaproteobacteria,1YG7B@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Pterin 4 alpha carbinolamine dehydratase phhB - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_10378_2 1049564.TevJSym_al00460 4.61e-126 372.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1J5MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 LpxK k59_62376_1 1123229.AUBC01000001_gene1478 6.17e-09 56.2 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,3JR6I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_62376_2 1121918.ARWE01000001_gene653 2.61e-55 174.0 COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_95274_1 338963.Pcar_3025 2.39e-75 233.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42NI8@68525|delta/epsilon subdivisions,2WKMZ@28221|Deltaproteobacteria,43U5P@69541|Desulfuromonadales 28221|Deltaproteobacteria P PFAM ABC transporter related - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_159402_1 1137281.D778_00222 2.11e-106 331.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia 976|Bacteroidetes M Membrane protein involved in D-alanine export - - - - - - - - - - - - MBOAT k59_113875_1 1121405.dsmv_0963 1.52e-91 281.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria,2MI34@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_172239_2 983917.RGE_09270 6.05e-33 136.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria,1KPDV@119065|unclassified Burkholderiales 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain qseC - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_127675_1 706587.Desti_4204 1.26e-186 528.0 COG0467@1|root,COG1476@1|root,COG1917@1|root,COG0467@2|Bacteria,COG1476@2|Bacteria,COG1917@2|Bacteria,1PE60@1224|Proteobacteria,42NFD@68525|delta/epsilon subdivisions,2WK1C@28221|Deltaproteobacteria,2MQST@213462|Syntrophobacterales 28221|Deltaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_55155_2 1150621.SMUL_2941 3.36e-77 238.0 COG0790@1|root,COG0790@2|Bacteria,1QWUU@1224|Proteobacteria 1224|Proteobacteria S T5orf172 - - - - - - - - - - - - T5orf172 k59_81770_1 498211.CJA_2509 1.22e-24 115.0 COG3210@1|root,COG3210@2|Bacteria,1QQD4@1224|Proteobacteria,1RZ1D@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Mandelate Racemase Muconate Lactonizing - - - - - - - - - - - - - k59_191736_1 1282876.BAOK01000001_gene2522 3.6e-22 94.0 2DNUQ@1|root,32Z94@2|Bacteria,1N568@1224|Proteobacteria,2UDMU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4281) - - - - - - - - - - - - DUF4281 k59_191736_2 1380355.JNIJ01000019_gene4597 5.61e-56 184.0 COG3644@1|root,COG3644@2|Bacteria,1RK12@1224|Proteobacteria,2U9IH@28211|Alphaproteobacteria,3JU7P@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2239) - - - ko:K09965 - - - - ko00000 - - - DUF2239 k59_191736_3 1562701.BBOF01000014_gene549 0.000692 45.8 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1KH1R@119060|Burkholderiaceae 28216|Betaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_191736_4 1123511.KB905872_gene1845 2.81e-34 130.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H53T@909932|Negativicutes 909932|Negativicutes L RNA-directed DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_191736_5 1079460.ATTQ01000045_gene6046 3.16e-67 213.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U28T@28211|Alphaproteobacteria,4BE1X@82115|Rhizobiaceae 28211|Alphaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_87962_1 338963.Pcar_2013 1.25e-48 169.0 COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,43T29@69541|Desulfuromonadales 28221|Deltaproteobacteria L nucleic acid binding OB-fold tRNA helicase-type yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon k59_43545_1 32049.SYNPCC7002_E0039 7.08e-129 391.0 COG2131@1|root,COG2131@2|Bacteria 2|Bacteria F dCMP deaminase activity - - 3.5.4.12,3.5.4.5 ko:K01489,ko:K01493 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00429 R01663,R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_127677_1 997884.HMPREF1068_01145 0.000123 46.6 COG1007@1|root,COG1007@2|Bacteria,4NF94@976|Bacteroidetes,2FNTS@200643|Bacteroidia,4AKJ3@815|Bacteroidaceae 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_127677_2 1202532.FF52_16759 5.04e-08 53.1 COG2905@1|root,COG2905@2|Bacteria,4NTDP@976|Bacteroidetes,1IC44@117743|Flavobacteriia,2NVVY@237|Flavobacterium 976|Bacteroidetes T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_68804_1 335543.Sfum_3172 5.15e-60 189.0 COG3829@1|root,COG3829@2|Bacteria,1QVJM@1224|Proteobacteria,43CC9@68525|delta/epsilon subdivisions,2X7N5@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PAS sensor protein - - - - - - - - - - - - PAS_4 k59_165629_1 1249627.D779_3656 6.96e-63 204.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RX39@1236|Gammaproteobacteria,1WXEH@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_95288_2 83406.HDN1F_20890 6.44e-16 82.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_179015_1 1547445.LO80_01895 2.16e-57 191.0 COG1708@1|root,COG1708@2|Bacteria,1PWC5@1224|Proteobacteria 1224|Proteobacteria S Nucleotidyltransferase - - - ko:K07076 - - - - ko00000 - - - HEPN,NTP_transf_2 k59_81873_1 1249627.D779_1706 1.91e-16 74.7 2E4UR@1|root,32ZP4@2|Bacteria,1N83W@1224|Proteobacteria,1SEK3@1236|Gammaproteobacteria,1WZ72@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_81873_2 395493.BegalDRAFT_1628 3.14e-83 255.0 COG1433@1|root,COG1433@2|Bacteria,1PW6J@1224|Proteobacteria,1S0X4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dinitrogenase iron-molybdenum cofactor nifY - - - - - - - - - - - DIMCO_N,Nitro_FeMo-Co k59_197928_2 1049564.TevJSym_ai00500 2.55e-135 393.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1J4KG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0109 QRPTase_C,QRPTase_N k59_62616_1 1236959.BAMT01000007_gene2615 2.14e-11 64.3 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,2KMJT@206350|Nitrosomonadales 206350|Nitrosomonadales C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_168153_2 96561.Dole_2664 1.73e-43 146.0 COG1661@1|root,COG1661@2|Bacteria,1NAWT@1224|Proteobacteria,42WJ4@68525|delta/epsilon subdivisions,2WRU1@28221|Deltaproteobacteria,2MNM8@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF296) - - - ko:K06934 - - - - ko00000 - - - DUF296 k59_155339_1 96561.Dole_2220 9.69e-69 218.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2MI9R@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_148948_1 1049564.TevJSym_ab01960 1.31e-145 426.0 COG1155@1|root,COG1155@2|Bacteria,1R22G@1224|Proteobacteria 1224|Proteobacteria C ATPsynthase alpha/beta subunit N-term extension - - - - - - - - - - - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_206845_1 710111.FraQA3DRAFT_2958 2.51e-15 80.1 COG3550@1|root,COG3550@2|Bacteria,2IBV4@201174|Actinobacteria 201174|Actinobacteria S HipA domain protein - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_206845_3 323261.Noc_2931 1.14e-41 148.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,1RNYG@1236|Gammaproteobacteria,1WXYY@135613|Chromatiales 135613|Chromatiales S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_206845_4 243265.plu2127 5.5e-46 150.0 COG1476@1|root,COG1476@2|Bacteria,1N7PK@1224|Proteobacteria,1SDGY@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_3 k59_206845_7 555088.DealDRAFT_1856 2.9e-07 53.5 COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,248YH@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - GyrI-like k59_77295_2 1121035.AUCH01000018_gene2751 1.1e-24 103.0 2EBVI@1|root,335UY@2|Bacteria,1R0Q7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_84204_1 207954.MED92_07121 3.81e-86 287.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XHW0@135619|Oceanospirillales 135619|Oceanospirillales NT helical bimodular (HBM) domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_84204_2 765912.Thimo_3237 1.31e-109 319.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,1RNTH@1236|Gammaproteobacteria,1WX4V@135613|Chromatiales 135613|Chromatiales C TIGRFAM Ni Fe-hydrogenase, b-type cytochrome subunit - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_18925_1 886293.Sinac_7397 2.12e-158 460.0 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_168167_1 1227457.C451_01233 8.4e-09 62.0 COG3039@1|root,arCOG02751@2157|Archaea,2XUAF@28890|Euryarchaeota,23UD8@183963|Halobacteria 183963|Halobacteria L COG3039 Transposase and inactivated derivatives, IS5 family - - - - - - - - - - - - DDE_Tnp_1 k59_116422_1 1042326.AZNV01000051_gene1271 6.07e-26 109.0 COG3203@1|root,COG3203@2|Bacteria,1RIIY@1224|Proteobacteria,2V9VT@28211|Alphaproteobacteria,4BA6Y@82115|Rhizobiaceae 28211|Alphaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_200184_1 1174504.AJTN02000035_gene3043 3.74e-46 162.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli,1ZQZX@1386|Bacillus 91061|Bacilli C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_206850_1 56780.SYN_01723 3.51e-60 207.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MQAI@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_194276_1 1249627.D779_3360 1.15e-107 333.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_206857_2 37682.EMT14609 7.45e-09 56.2 COG0428@1|root,COG2214@1|root,KOG0719@2759|Eukaryota,KOG2474@2759|Eukaryota,37ISQ@33090|Viridiplantae,3G8GJ@35493|Streptophyta,3KSPY@4447|Liliopsida,3IFEY@38820|Poales 35493|Streptophyta O DnaJ domain - - - ko:K07238,ko:K09529 - - - - ko00000,ko02000,ko03110 2.A.5.5 - - DnaJ k59_168174_1 985665.HPL003_27860 3.25e-09 60.8 COG1132@1|root,COG1132@2|Bacteria,1TSY4@1239|Firmicutes,4HAJQ@91061|Bacilli,26R59@186822|Paenibacillaceae 91061|Bacilli V ABC-type multidrug transport system, ATPase and permease yvcC3 - 3.6.3.44 ko:K02021,ko:K18104 ko01501,ko02010,map01501,map02010 M00700 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.123,3.A.1.21 - - ABC_membrane,ABC_tran k59_168174_2 1347392.CCEZ01000016_gene2971 3.48e-10 65.9 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36E8H@31979|Clostridiaceae 186801|Clostridia C Radical SAM domain protein - - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,NUDIX,PqqD,Radical_SAM,SPASM k59_168174_4 1121937.AUHJ01000021_gene1432 4.19e-11 63.2 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_155349_1 396588.Tgr7_0336 1.3e-143 415.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales 135613|Chromatiales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_206862_1 42099.EPrPV00000018532 0.000238 46.6 COG0169@1|root,KOG0692@2759|Eukaryota,1MCHP@121069|Pythiales 121069|Pythiales E Pentafunctional AROM polypeptide - - - - - - - - - - - - DHQ_synthase,DHquinase_I,EPSP_synthase,SKI,Shikimate_DH,Shikimate_dh_N k59_206862_2 243231.GSU1828 2.24e-14 70.5 COG1605@1|root,COG1605@2|Bacteria,1Q1RX@1224|Proteobacteria,42U9H@68525|delta/epsilon subdivisions,2WQ7P@28221|Deltaproteobacteria,43SMW@69541|Desulfuromonadales 28221|Deltaproteobacteria E Chorismate mutase type II - - 5.4.99.5 ko:K04093 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2 k59_206862_3 323259.Mhun_1034 5.36e-26 105.0 COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia 224756|Methanomicrobia E Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis aroB' - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_181373_2 1114970.PSF113_3165 1.86e-13 75.5 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria 1236|Gammaproteobacteria M rhs family - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_90662_1 999141.GME_19152 1.32e-21 98.2 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,1XH6I@135619|Oceanospirillales 135619|Oceanospirillales M Rhs family - - - - - - - - - - - - RHS,RHS_repeat,Tox-HNH-EHHH k59_90662_2 1280946.HY29_17560 6.45e-22 94.0 2F79Y@1|root,33ZR6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_174455_1 717231.Flexsi_1991 1.39e-15 82.4 COG3303@1|root,COG3303@2|Bacteria,2GG7G@200930|Deferribacteres 200930|Deferribacteres C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_57565_6 1122915.AUGY01000004_gene5574 2.44e-05 56.2 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - - - - - - - - - - - FHA,NB-ARC,PDZ,PDZ_2,PPC,Trypsin,Trypsin_2 k59_57565_7 483215.BACFIN_06596 7.17e-52 183.0 COG0438@1|root,COG0438@2|Bacteria,4NPNN@976|Bacteroidetes,2FRYN@200643|Bacteroidia,4AVK4@815|Bacteroidaceae 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_5675_1 1117108.PAALTS15_18173 6.01e-10 58.9 COG3391@1|root,COG4447@1|root,COG3391@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1,3.4.24.40 ko:K00505,ko:K01406 ko00350,ko00950,ko00965,ko01100,ko01110,ko01503,ko04916,map00350,map00950,map00965,map01100,map01110,map01503,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000,ko01002 - - - - k59_5675_2 99598.Cal7507_3739 2.65e-232 674.0 COG3292@1|root,COG3292@2|Bacteria,1G8JD@1117|Cyanobacteria 1117|Cyanobacteria T Two component regulator propeller - - - - - - - - - - - - Tail_P2_I k59_90666_1 880072.Desac_2147 4.72e-95 304.0 COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase large chain, oligomerisation - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0661 CPSase_L_D2,CPSase_L_D3,MGS k59_168180_2 1348657.M622_18840 2.33e-34 119.0 2EF4E@1|root,338XK@2|Bacteria,1N8F4@1224|Proteobacteria,2VXDI@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - NMN_transporter k59_168180_3 991905.SL003B_0644 4.3e-40 144.0 COG0582@1|root,COG0582@2|Bacteria,1MXNK@1224|Proteobacteria,2TUAT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase - - - - - - - - - - - - Phage_integrase k59_168180_5 472759.Nhal_3522 0.00044 41.2 COG4226@1|root,COG4226@2|Bacteria 2|Bacteria K protein encoded in hypervariable junctions of pilus gene clusters - - - - - - - - - - - - HicB k59_174457_1 644282.Deba_0655 8.3e-10 61.6 COG3103@1|root,COG4913@1|root,COG3103@2|Bacteria,COG4913@2|Bacteria,1R1CB@1224|Proteobacteria,43D8S@68525|delta/epsilon subdivisions,2X8FE@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial SH3 domain - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_142423_1 1121396.KB893067_gene1544 6.03e-31 116.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2WQQM@28221|Deltaproteobacteria,2MK2T@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM conserved - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_116464_2 1049564.TevJSym_as00060 1.76e-64 206.0 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1JBX4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_200205_2 279010.BL02338 9.19e-65 209.0 COG0500@1|root,COG2226@2|Bacteria,1TSAZ@1239|Firmicutes,4HFFF@91061|Bacilli,1ZCGP@1386|Bacillus 91061|Bacilli Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_200205_3 870187.Thini_3088 4.35e-53 178.0 COG0744@1|root,COG0744@2|Bacteria,1RDYG@1224|Proteobacteria 1224|Proteobacteria M Transglycosylase - - - - - - - - - - - - Transgly k59_200205_4 1123487.KB892839_gene175 1.21e-106 325.0 28PX9@1|root,30IY1@2|Bacteria,1NHH8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_32304_2 1415778.JQMM01000001_gene856 2.73e-86 266.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1J4HG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_155364_1 1132855.KB913035_gene144 1.59e-38 130.0 2AM36@1|root,31BX9@2|Bacteria,1P030@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_155364_2 335659.S23_57340 8.48e-58 201.0 COG1479@1|root,COG1479@2|Bacteria,1R63V@1224|Proteobacteria,2U1N6@28211|Alphaproteobacteria,3K1JC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function DUF262 - - - - - - - - - - - - DUF262 k59_18954_1 177437.HRM2_41800 2.54e-97 299.0 2DBU2@1|root,2ZB3S@2|Bacteria,1N1MT@1224|Proteobacteria,42VJX@68525|delta/epsilon subdivisions,2WSPP@28221|Deltaproteobacteria,2MNKM@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - DDE_Tnp_1_4 k59_142429_1 1265505.ATUG01000002_gene1612 6.05e-47 169.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2MIJB@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_58100_1 373903.Hore_11670 9.78e-48 175.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WA7U@53433|Halanaerobiales 186801|Clostridia L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_174940_1 765911.Thivi_3135 2.51e-53 177.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,1RY1X@1236|Gammaproteobacteria,1WW3S@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_174940_2 1049564.TevJSym_aw00310 7.13e-34 121.0 28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,1RS8I@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_58116_2 1049564.TevJSym_av00220 2.21e-15 75.5 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1J5KR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - 2.7.10.1 ko:K08252 - - - - ko00000,ko01000 - - - AAA_31 k59_200808_1 713586.KB900536_gene139 7.63e-98 290.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_58121_1 338963.Pcar_0596 3.36e-78 248.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,43S0N@69541|Desulfuromonadales 28221|Deltaproteobacteria P Divalent cation transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_174955_1 177437.HRM2_36780 3.04e-63 209.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_200834_1 754477.Q7C_1743 1.28e-51 164.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,460WX@72273|Thiotrichales 72273|Thiotrichales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_200834_2 314287.GB2207_11803 8.26e-10 58.5 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1J4FJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009987,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019058,GO:0019068,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0044183,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0097159,GO:0097367,GO:0101031,GO:1901265,GO:1901363,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_6311_1 439235.Dalk_0268 1.27e-74 241.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_207327_1 1223410.KN050846_gene2460 5.8e-16 82.8 COG2304@1|root,COG2911@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,4PKD0@976|Bacteroidetes,1HWKJ@117743|Flavobacteriia 976|Bacteroidetes U Large extracellular alpha-helical protein - - - - - - - - - - - - CHU_C,HYR,LRR_adjacent k59_58163_1 1121405.dsmv_2546 2.06e-25 108.0 COG0457@1|root,COG0457@2|Bacteria,1RDNA@1224|Proteobacteria,42Q5I@68525|delta/epsilon subdivisions,2WIX0@28221|Deltaproteobacteria,2MJTP@213118|Desulfobacterales 28221|Deltaproteobacteria T TPR repeat - - - - - - - - - - - - GGDEF,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8 k59_6341_1 323261.Noc_1631 2.01e-38 139.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWVI@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_58167_1 1049564.TevJSym_as00660 3.64e-212 614.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_6352_1 1306174.JODP01000013_gene7441 1.51e-72 229.0 COG0646@1|root,COG0646@2|Bacteria 2|Bacteria E methionine synthase metH - 2.1.1.13,2.1.1.5 ko:K00544,ko:K00548 ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R02821,R09365 RC00035,RC00113,RC00496,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_200892_1 224325.AF_0351 0.000107 44.3 COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,24648@183980|Archaeoglobi 183980|Archaeoglobi T recA bacterial DNA recombination protein - - - - - - - - - - - - ATPase k59_200892_2 1449357.JQLK01000001_gene1762 4.46e-25 104.0 COG0422@1|root,COG0422@2|Bacteria,1WIF4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_6387_1 1453501.JELR01000005_gene1714 3.79e-73 246.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,464QF@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_6400_1 331678.Cphamn1_1145 2.25e-38 142.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family int - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_200923_2 266264.Rmet_0556 3.47e-39 140.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2VQ5Z@28216|Betaproteobacteria,1K1U9@119060|Burkholderiaceae 28216|Betaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379,ko:K18360 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001 - - - FdhD-NarQ k59_6410_2 1123399.AQVE01000004_gene2538 1.61e-53 182.0 COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF697) - - - - - - - - - - - - DUF697,MMR_HSR1 k59_58229_1 686340.Metal_0706 2.12e-14 68.9 COG4639@1|root,COG4639@2|Bacteria,1N0U7@1224|Proteobacteria,1SC5J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - AAA_33 k59_58229_2 1121935.AQXX01000116_gene5170 1.88e-140 402.0 COG4021@1|root,COG4021@2|Bacteria,1MX0R@1224|Proteobacteria,1SKIR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tRNAHis guanylyltransferase - - - - - - - - - - - - Thg1,Thg1C k59_6421_2 1158292.JPOE01000006_gene3948 6.06e-18 77.0 COG3905@1|root,COG3905@2|Bacteria,1N39N@1224|Proteobacteria,2VUG6@28216|Betaproteobacteria 28216|Betaproteobacteria K .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - - - - - - - - - - - k59_6460_2 880072.Desac_1171 4.55e-182 514.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,2MQB1@213462|Syntrophobacterales 28221|Deltaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_58336_1 1167006.UWK_02832 3.26e-85 266.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42MIH@68525|delta/epsilon subdivisions,2WK3V@28221|Deltaproteobacteria,2MIQC@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM EAL domain - - - - - - - - - - - - EAL,HDOD k59_58336_2 177437.HRM2_32900 4.32e-11 62.4 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,42R83@68525|delta/epsilon subdivisions,2WN00@28221|Deltaproteobacteria,2MJHD@213118|Desulfobacterales 28221|Deltaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_71453_2 326427.Cagg_2365 1.99e-65 211.0 COG0444@1|root,COG0444@2|Bacteria,2G5PT@200795|Chloroflexi,3750T@32061|Chloroflexia 32061|Chloroflexia P TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_119548_1 765910.MARPU_16675 1.08e-84 270.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_35102_1 631362.Thi970DRAFT_03245 2.42e-83 260.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales 135613|Chromatiales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_22212_1 1049564.TevJSym_ai00300 1.4e-72 229.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1J4VW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway, component PulF pilC GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009297,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032940,GO:0033036,GO:0042886,GO:0043711,GO:0044085,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0098776 - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_112780_1 2340.JV46_21380 4.72e-141 408.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1J4G7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glycine cleavage system T protein gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_2953 GCV_T,GCV_T_C k59_151773_1 1121403.AUCV01000018_gene3185 2.42e-25 106.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg,dCache_1 k59_151773_2 1235788.C802_03122 5.67e-46 156.0 COG1335@1|root,COG1335@2|Bacteria,4NMQE@976|Bacteroidetes,2FSUI@200643|Bacteroidia,4ATXI@815|Bacteroidaceae 976|Bacteroidetes Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_119550_1 56780.SYN_02126 1.13e-130 382.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MQ79@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS-1 - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_145344_1 765869.BDW_03970 5.14e-09 62.8 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2MSR8@213481|Bdellovibrionales,2WJZF@28221|Deltaproteobacteria 213481|Bdellovibrionales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_164487_2 747365.Thena_0443 6.63e-37 128.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,42GWD@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_164487_3 396588.Tgr7_1143 3e-22 94.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1X29U@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_9096_2 667632.KB890179_gene152 5.73e-27 103.0 COG3620@1|root,COG3620@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - DUF4870,HTH_3,HTH_31 k59_190606_1 1219084.AP014508_gene1056 0.000358 48.9 COG1196@1|root,COG1196@2|Bacteria,2GBZE@200918|Thermotogae 200918|Thermotogae D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_93652_1 880072.Desac_0544 1.16e-45 164.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_93652_2 644282.Deba_0653 6e-49 172.0 COG1906@1|root,COG1906@2|Bacteria,1RAQQ@1224|Proteobacteria,42QZ0@68525|delta/epsilon subdivisions,2WMXK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF401) - - - ko:K09133 - - - - ko00000 - - - DUF401 k59_35106_1 96561.Dole_0773 3.91e-77 244.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,2MI35@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_171307_1 857087.Metme_4167 2.05e-45 180.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XGAS@135618|Methylococcales 135618|Methylococcales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_112781_1 1163617.SCD_n02706 4.79e-146 428.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_99451_1 1129374.AJE_08285 4.89e-13 74.7 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,4653Y@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_99451_2 1229205.BUPH_02884 9.61e-25 100.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1JZNK@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_132498_1 83406.HDN1F_35210 2.59e-49 157.0 COG3905@1|root,COG3905@2|Bacteria,1N8CE@1224|Proteobacteria,1SAXF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - RHH_1 k59_132498_2 391735.Veis_3353 9.32e-55 172.0 COG3668@1|root,COG3668@2|Bacteria,1N9C2@1224|Proteobacteria,2VTM0@28216|Betaproteobacteria,4AJM0@80864|Comamonadaceae 28216|Betaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_132498_3 1144325.PMI22_05792 6.98e-05 45.1 COG3905@1|root,COG3905@2|Bacteria,1MZPQ@1224|Proteobacteria,1S8Y6@1236|Gammaproteobacteria 1236|Gammaproteobacteria K copG family - - - - - - - - - - - - RHH_1 k59_196645_2 338969.Rfer_0255 1.07e-39 144.0 COG3303@1|root,COG3303@2|Bacteria,1NX4E@1224|Proteobacteria 1224|Proteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_106135_1 768671.ThimaDRAFT_4614 5.17e-39 144.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales 135613|Chromatiales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_106135_3 1121382.JQKG01000001_gene2270 1.54e-129 383.0 COG0722@1|root,COG0722@2|Bacteria,1WKXX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E DAHP synthetase I family - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_106135_5 1123248.KB893326_gene1444 3.75e-11 72.8 COG1749@1|root,COG2372@1|root,COG4625@1|root,COG5184@1|root,COG1749@2|Bacteria,COG2372@2|Bacteria,COG4625@2|Bacteria,COG5184@2|Bacteria,4NTUT@976|Bacteroidetes 976|Bacteroidetes N Domain of unknown function (DUF4082) - - - - - - - - - - - - Cu-binding_MopE,DUF4082 k59_106135_6 33035.JPJF01000008_gene1219 3.18e-11 68.9 COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia,3Y08M@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - DUF218 k59_106135_7 1049564.TevJSym_ab01780 8.19e-254 727.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMFB@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_47888_1 404380.Gbem_2041 2.57e-24 99.0 COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,42M7B@68525|delta/epsilon subdivisions,2WJUM@28221|Deltaproteobacteria,43T9V@69541|Desulfuromonadales 28221|Deltaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_47888_2 443143.GM18_2166 8.49e-11 62.0 COG1305@1|root,COG1305@2|Bacteria,1MY5V@1224|Proteobacteria,42M7B@68525|delta/epsilon subdivisions,2WJUM@28221|Deltaproteobacteria,43T9V@69541|Desulfuromonadales 28221|Deltaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_28485_1 272560.BPSS1453 5.91e-67 232.0 COG0019@1|root,COG4638@1|root,COG0019@2|Bacteria,COG4638@2|Bacteria,1MW3T@1224|Proteobacteria,2VR86@28216|Betaproteobacteria,1KE46@119060|Burkholderiaceae 28216|Betaproteobacteria EP Pyridoxal-dependent decarboxylase, C-terminal sheet domain nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC,Rieske,Ring_hydroxyl_A k59_126038_1 520709.F985_01742 1.19e-46 155.0 COG2050@1|root,COG2050@2|Bacteria,1RK46@1224|Proteobacteria,1S68C@1236|Gammaproteobacteria,3NJDA@468|Moraxellaceae 1236|Gammaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_126038_2 1265505.ATUG01000001_gene4392 5.78e-44 147.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_93919_3 1049564.TevJSym_ai00950 7.26e-49 158.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1J6BH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Endoribonuclease L-PSP tdcF - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_86977_1 983545.Glaag_3394 5.47e-46 157.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,464HA@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_158272_1 1095769.CAHF01000023_gene566 3.19e-85 266.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,4763B@75682|Oxalobacteraceae 28216|Betaproteobacteria M UDP binding domain - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_54377_3 156889.Mmc1_0793 3.25e-08 53.1 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,2U6FZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_151907_2 598467.BrE312_4495 7.54e-124 362.0 COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,1RPD9@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM NmrA family qorB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.6.5.2 ko:K19267 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - NAD_binding_10,NmrA k59_151907_3 218491.ECA4450 1.62e-55 176.0 COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,1S5WB@1236|Gammaproteobacteria,1MSI2@122277|Pectobacterium 1236|Gammaproteobacteria K HxlR-like helix-turn-helix ytfH - - - - - - - - - - - HxlR k59_151907_4 1121935.AQXX01000115_gene5004 2.3e-103 318.0 2AK3X@1|root,3369U@2|Bacteria,1N7U0@1224|Proteobacteria,1SD30@1236|Gammaproteobacteria,1XPZU@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_151907_5 349521.HCH_01997 4.67e-166 475.0 2CAGX@1|root,2Z7W4@2|Bacteria,1P64Q@1224|Proteobacteria,1RPYY@1236|Gammaproteobacteria,1XPMG@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_151907_6 1110502.TMO_0868 4.36e-116 342.0 COG2113@1|root,COG2113@2|Bacteria,1R5CU@1224|Proteobacteria,2U0AN@28211|Alphaproteobacteria,2JQF8@204441|Rhodospirillales 204441|Rhodospirillales E Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k59_151907_7 1121033.AUCF01000013_gene1585 3.43e-120 353.0 COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,2VF3T@28211|Alphaproteobacteria,2JZKV@204441|Rhodospirillales 204441|Rhodospirillales E Binding-protein-dependent transport system inner membrane component - - - ko:K02001 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1 k59_151907_8 748658.KB907318_gene1039 2.57e-108 328.0 COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,1RN2R@1236|Gammaproteobacteria,1WWUZ@135613|Chromatiales 135613|Chromatiales E glycine betaine - - 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran,CBS k59_61181_1 765912.Thimo_1963 7.17e-26 97.8 COG2841@1|root,COG2841@2|Bacteria,1N760@1224|Proteobacteria,1SCCY@1236|Gammaproteobacteria,1WYVF@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF465) - - - ko:K09794 - - - - ko00000 - - - DUF465 k59_61181_2 1049564.TevJSym_aq00330 7.58e-209 607.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1J4D7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG1305 Transglutaminase-like enzymes tgpA - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_61181_3 1049564.TevJSym_aq00340 2.46e-84 263.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1J60U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_61181_4 1163617.SCD_n01287 1.48e-104 312.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_3 moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_15244_2 1123373.ATXI01000001_gene579 6.92e-05 47.0 COG0589@1|root,COG0589@2|Bacteria,2GH02@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_106351_1 56780.SYN_00609 2.45e-110 338.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,2MQAC@213462|Syntrophobacterales 28221|Deltaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_171491_1 880072.Desac_1143 3.53e-130 401.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_86979_1 378806.STAUR_6049 1.4e-61 201.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2YTZQ@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_86979_2 1125863.JAFN01000001_gene969 1.53e-34 124.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_15246_2 28072.Nos7524_1228 4e-09 60.5 COG2214@1|root,COG2214@2|Bacteria,1G6E4@1117|Cyanobacteria 1117|Cyanobacteria O DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - - - - - - - - - - DnaJ k59_22397_1 187303.BN69_0596 0.000211 50.1 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria,36XMW@31993|Methylocystaceae 28211|Alphaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat protein MA20_34510 - - - - - - - - - - - Cytochrom_D1,Lactonase k59_61184_1 335543.Sfum_0679 2.58e-98 313.0 COG0617@1|root,COG0618@1|root,COG3620@1|root,COG0617@2|Bacteria,COG0618@2|Bacteria,COG3620@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MQAY@213462|Syntrophobacterales 28221|Deltaproteobacteria J tRNA nucleotidyltransferase poly(A) polymerase ccaA - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_73734_1 1049564.TevJSym_ab00640 2.8e-16 76.3 COG1136@1|root,COG1136@2|Bacteria,1RCXK@1224|Proteobacteria,1S7TZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria V abc transporter atp-binding protein attE - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_73734_2 1049564.TevJSym_ab00650 1.38e-180 522.0 COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S serine threonine protein kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - VWA,VWA_2 k59_132714_1 338963.Pcar_1080 2.78e-76 232.0 COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42SSF@68525|delta/epsilon subdivisions,2WPME@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_132714_2 1304885.AUEY01000009_gene1949 5.81e-121 357.0 COG4977@1|root,COG4977@2|Bacteria,1QTV9@1224|Proteobacteria,43CQR@68525|delta/epsilon subdivisions,2X7Y7@28221|Deltaproteobacteria,2MPPF@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_N,HTH_18 k59_99633_2 313606.M23134_04873 1.91e-30 112.0 COG1586@1|root,COG1586@2|Bacteria,4NVRA@976|Bacteroidetes,47RGR@768503|Cytophagia 976|Bacteroidetes E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_119802_1 706587.Desti_1171 6.16e-133 407.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2MREI@213462|Syntrophobacterales 28221|Deltaproteobacteria H Pyruvate phosphate dikinase, PEP - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_158277_1 1049564.TevJSym_aa00920 7.19e-29 104.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1J6N0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain fdx1 - - - - - - - - - - - Fer4 k59_151914_1 477228.YO5_01046 6.52e-90 279.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1Z3VI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Outer membrane efflux protein - - - ko:K18300 - M00641 - - ko00000,ko00002,ko01504,ko02000 1.B.17 - - OEP k59_184610_1 497965.Cyan7822_0252 4.29e-37 143.0 COG0312@1|root,COG0312@2|Bacteria,1G230@1117|Cyanobacteria,3KGN6@43988|Cyanothece 1117|Cyanobacteria L peptidase U62, modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_42131_1 1174528.JH992890_gene581 6.95e-33 128.0 COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,1JHHS@1189|Stigonemataceae 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,HNH,RVT_1,RVT_N k59_28653_1 335543.Sfum_2756 6.38e-67 225.0 COG0707@1|root,COG1413@1|root,COG0707@2|Bacteria,COG1413@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2MRPC@213462|Syntrophobacterales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_132715_1 177437.HRM2_39480 1.64e-32 134.0 COG3385@1|root,COG3385@2|Bacteria,1RM2A@1224|Proteobacteria,42WE3@68525|delta/epsilon subdivisions,2X6QW@28221|Deltaproteobacteria,2MN97@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_9302_2 1121011.AUCB01000020_gene3608 1.72e-63 210.0 COG1573@1|root,COG1573@2|Bacteria 2|Bacteria L deaminated base DNA N-glycosylase activity smuG - - ko:K10800 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_9302_3 1288494.EBAPG3_18660 1.79e-129 394.0 COG0402@1|root,COG0402@2|Bacteria,1R9S5@1224|Proteobacteria,2W13M@28216|Betaproteobacteria,37499@32003|Nitrosomonadales 28216|Betaproteobacteria F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_9302_4 1288494.EBAPG3_30940 1.03e-165 493.0 COG0793@1|root,COG0793@2|Bacteria,1R88N@1224|Proteobacteria,2W1SE@28216|Betaproteobacteria 28216|Betaproteobacteria M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k59_9302_5 1123393.KB891328_gene533 3.45e-54 183.0 COG0475@1|root,COG0475@2|Bacteria,1PK6S@1224|Proteobacteria,2VZ60@28216|Betaproteobacteria,1KTFQ@119069|Hydrogenophilales 119069|Hydrogenophilales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_119813_1 1121405.dsmv_2917 1.33e-27 107.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P3C@68525|delta/epsilon subdivisions,2WJW1@28221|Deltaproteobacteria,2MIUF@213118|Desulfobacterales 28221|Deltaproteobacteria F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_119813_2 1121422.AUMW01000017_gene1978 3.09e-16 81.3 COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia 186801|Clostridia S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase k59_15258_1 592316.Pat9b_3707 4.91e-47 169.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,3VZDG@53335|Pantoea 1236|Gammaproteobacteria G Alpha amylase catalytic region ycjM - 2.4.1.7 ko:K00690 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_160333_1 1158318.ATXC01000001_gene1096 1.76e-33 126.0 COG1465@1|root,COG1465@2|Bacteria,2G4EK@200783|Aquificae 200783|Aquificae E Belongs to the archaeal-type DHQ synthase family - - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_160333_2 880072.Desac_0652 2.4e-107 316.0 COG1830@1|root,COG1830@2|Bacteria,1MWJW@1224|Proteobacteria,42NP9@68525|delta/epsilon subdivisions,2WIP9@28221|Deltaproteobacteria,2MRSW@213462|Syntrophobacterales 28221|Deltaproteobacteria H DeoC/LacD family aldolase aroA' - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_153581_2 373994.Riv7116_0084 5.13e-40 138.0 COG2345@1|root,COG2345@2|Bacteria,1G44B@1117|Cyanobacteria,1HNC2@1161|Nostocales 1117|Cyanobacteria K Transcriptional regulator - - - ko:K07013 - - - - ko00000 - - - - k59_179796_2 1042377.AFPJ01000009_gene181 2.38e-08 55.8 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,4674R@72275|Alteromonadaceae 1236|Gammaproteobacteria S Hydrolase gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_44632_1 511062.GU3_06220 6.02e-92 283.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1Y3KP@135624|Aeromonadales 135624|Aeromonadales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_172747_1 391587.KAOT1_22021 2.66e-41 147.0 COG5285@1|root,COG5285@2|Bacteria,4NIIV@976|Bacteroidetes,1HZHD@117743|Flavobacteriia 976|Bacteroidetes Q Phytanoyl-CoA dioxygenase - - - - - - - - - - - - PhyH k59_128576_1 1210884.HG799470_gene14561 2.39e-40 150.0 COG3385@1|root,COG3385@2|Bacteria,2J32V@203682|Planctomycetes 203682|Planctomycetes L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_44633_1 387631.Asulf_01565 2.72e-56 181.0 COG1853@1|root,arCOG02017@2157|Archaea,2XXVW@28890|Euryarchaeota,24720@183980|Archaeoglobi 183980|Archaeoglobi S Flavin reductase like domain - - 1.16.1.10 ko:K18915 - - - - ko00000,ko01000 - - - Flavin_Reduct k59_134405_2 697282.Mettu_0209 7.91e-25 109.0 COG3209@1|root,COG4447@1|root,COG3209@2|Bacteria,COG4447@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XGAS@135618|Methylococcales 135618|Methylococcales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_55897_3 768671.ThimaDRAFT_1994 3.86e-28 111.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_153583_1 1395587.P364_0120485 9.4e-38 131.0 COG0454@1|root,COG0456@2|Bacteria,1VW2R@1239|Firmicutes,4I7IK@91061|Bacilli,26WWV@186822|Paenibacillaceae 91061|Bacilli K GNAT family acetyltransferase - - - - - - - - - - - - Acetyltransf_10 k59_88816_1 1089553.Tph_c26380 2.06e-13 68.9 COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24JKC@186801|Clostridia,42GW5@68295|Thermoanaerobacterales 186801|Clostridia G Phosphoglycerate mutase family - - 3.1.3.3 ko:K22305 ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130 - R00582 RC00017 ko00000,ko00001,ko01000 - - - His_Phos_1 k59_88816_2 335543.Sfum_3753 7.88e-05 44.7 COG0826@1|root,COG0826@2|Bacteria,1N4QJ@1224|Proteobacteria,42YJR@68525|delta/epsilon subdivisions,2WUQ1@28221|Deltaproteobacteria,2MR6V@213462|Syntrophobacterales 28221|Deltaproteobacteria O Peptidase family U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_192527_1 2340.JV46_19710 1.23e-92 281.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,1RSA6@1236|Gammaproteobacteria,1J9BK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pyridine nucleotide-disulphide oxidoreductase sqr - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_172748_1 880072.Desac_2529 1.57e-107 318.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MQBF@213462|Syntrophobacterales 28221|Deltaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_122074_3 314275.MADE_1009200 3.65e-47 159.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,466G2@72275|Alteromonadaceae 1236|Gammaproteobacteria L restriction endonuclease - - - - - - - - - - - - HNH_5 k59_122074_5 765913.ThidrDRAFT_3611 4.32e-30 125.0 COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1N26H@1224|Proteobacteria 1224|Proteobacteria T Sulfatase-modifying factor enzyme 1 - - - ko:K13730 ko05100,map05100 - - - ko00000,ko00001 - - - DUF4062,FGE-sulfatase,NACHT k59_166411_1 880072.Desac_0313 6.36e-41 140.0 COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_82776_3 1049564.TevJSym_ax00440 1.02e-52 168.0 COG1974@1|root,COG1974@2|Bacteria,1QUQ8@1224|Proteobacteria,1T20V@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_134654_1 933262.AXAM01000011_gene1756 5.45e-90 275.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MJ3H@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_17287_1 247490.KSU1_B0631 5.62e-41 152.0 COG0265@1|root,COG0265@2|Bacteria,2IY5I@203682|Planctomycetes 203682|Planctomycetes O PDZ domain (Also known as DHR - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_11564_1 1121468.AUBR01000036_gene1308 6.29e-69 235.0 COG2203@1|root,COG3437@1|root,COG3605@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3605@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales 186801|Clostridia T HD domain - - - - - - - - - - - - GAF_2,HD,PocR,SBP_bac_3 k59_114946_1 7668.SPU_002431-tr 2.3e-11 64.7 COG1132@1|root,KOG0055@2759|Eukaryota,38E88@33154|Opisthokonta,3B958@33208|Metazoa,3CVKH@33213|Bilateria 33208|Metazoa Q ATPase activity, coupled to transmembrane movement of substances pgp-2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016043,GO:0019915,GO:0031090,GO:0031410,GO:0031982,GO:0033036,GO:0043226,GO:0043227,GO:0043229,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0044840,GO:0044841,GO:0051179,GO:0051235,GO:0065007,GO:0065008,GO:0071840,GO:0097708 3.6.3.44 ko:K05658,ko:K05659 ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226 - - - ko00000,ko00001,ko01000,ko02000,ko04090,ko04147 3.A.1.201 - - ABC_membrane,ABC_tran k59_114946_2 207954.MED92_07076 1.99e-31 121.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XHB6@135619|Oceanospirillales 135619|Oceanospirillales M transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_192764_1 927704.SELR_06440 3.86e-26 104.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,4H22M@909932|Negativicutes 909932|Negativicutes D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_192764_2 398767.Glov_1922 3.88e-19 88.6 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_122347_1 1125863.JAFN01000001_gene1981 3.81e-80 249.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_37599_1 83406.HDN1F_16550 8.05e-14 71.2 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1J4ZW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_37599_2 1049564.TevJSym_au00260 3.71e-268 738.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1J4N7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_96499_1 1144275.COCOR_06580 2.88e-08 59.7 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver cqsS GO:0000155,GO:0000156,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K03413,ko:K10916 ko02020,ko02024,ko02030,ko05111,map02020,map02024,map02030,map05111 M00506,M00513 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,Response_reg k59_56106_3 1049564.TevJSym_ab00060 2.33e-76 237.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1J4FK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0835 Chemotaxis signal transduction protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_172925_1 1267533.KB906734_gene3895 1.52e-17 89.4 COG1721@1|root,COG1721@2|Bacteria 2|Bacteria E protein (some members contain a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - DUF11,DUF58 k59_82784_1 690850.Desaf_2591 4.41e-49 176.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_160628_1 234267.Acid_7639 1.22e-134 394.0 COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria 57723|Acidobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1,RVT_N k59_24580_1 177437.HRM2_12370 1.13e-67 229.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_198761_1 941449.dsx2_2172 1.55e-30 114.0 COG0500@1|root,COG2226@2|Bacteria,1RKJ7@1224|Proteobacteria,42T77@68525|delta/epsilon subdivisions,2WT2E@28221|Deltaproteobacteria,2M8S2@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_63528_1 1121405.dsmv_2616 2.25e-38 137.0 COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2MN1E@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_108801_6 1049564.TevJSym_ad00740 4.71e-75 232.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria,1J6JS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_37603_2 666686.B1NLA3E_13365 2.99e-24 103.0 COG1290@1|root,COG1290@2|Bacteria,1TP6M@1239|Firmicutes,4H9XV@91061|Bacilli,1ZB3U@1386|Bacillus 91061|Bacilli C COG1290 Cytochrome b subunit of the bc complex - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_N_2 k59_37603_3 330214.NIDE3889 1.67e-47 165.0 COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3J0Q6@40117|Nitrospirae 2|Bacteria C Cytochrome b/b6/petB qcrC - - ko:K00412,ko:K03888 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B,Cytochrome_CBB3 k59_17293_1 391009.Tmel_0335 3.6e-13 75.1 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,2GCKV@200918|Thermotogae 200918|Thermotogae T GAF domain - - - - - - - - - - - - GAF_2,HD k59_17293_2 118168.MC7420_7027 3.17e-07 59.7 COG1357@1|root,COG1357@2|Bacteria,1G7N7@1117|Cyanobacteria,1HH49@1150|Oscillatoriales 1117|Cyanobacteria S Pentapeptide repeats (9 copies) - - - - - - - - - - - - Pentapeptide k59_11582_1 338963.Pcar_2451 5.65e-08 59.3 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2WJ7J@28221|Deltaproteobacteria,43S9I@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_101701_1 2340.JV46_18690 5.35e-52 167.0 arCOG05193@1|root,2ZZSG@2|Bacteria,1REJB@1224|Proteobacteria,1SQYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_101701_2 203122.Sde_2346 9.25e-173 493.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,464W8@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_166637_1 335543.Sfum_2379 4.7e-73 276.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MR92@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR,Response_reg,dCache_1 k59_30739_1 105559.Nwat_0174 3.8e-69 221.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_147535_1 1122211.JMLW01000022_gene2549 3.84e-15 72.4 COG2963@1|root,COG2963@2|Bacteria,1NGD6@1224|Proteobacteria,1SGJ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - - k59_172931_1 909663.KI867150_gene1556 1.81e-08 53.9 arCOG05253@1|root,31CTK@2|Bacteria,1RIYS@1224|Proteobacteria,42T7T@68525|delta/epsilon subdivisions,2WP9R@28221|Deltaproteobacteria,2MQHS@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_56122_1 1247024.JRLH01000006_gene2694 2.1e-08 53.9 2DR0Q@1|root,339PT@2|Bacteria,1NM26@1224|Proteobacteria,1SJC7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_30746_1 933262.AXAM01000016_gene177 4.84e-82 270.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2MIWJ@213118|Desulfobacterales 28221|Deltaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_160634_1 1056820.KB900674_gene2592 8.92e-41 137.0 2BKDJ@1|root,332N0@2|Bacteria,1NEJT@1224|Proteobacteria,1RU7J@1236|Gammaproteobacteria,2PQE3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_160634_3 62928.azo0062 8.92e-48 167.0 COG0247@1|root,COG0247@2|Bacteria,1QV1F@1224|Proteobacteria,2WGPC@28216|Betaproteobacteria,2KYGB@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_192772_4 1499967.BAYZ01000181_gene4510 8.89e-56 177.0 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity - - 4.1.1.44 ko:K01607,ko:K04756 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD,Cupin_2 k59_192772_5 392500.Swoo_0090 5.24e-13 69.7 COG0454@1|root,COG0454@2|Bacteria,1QVZJ@1224|Proteobacteria,1T2PE@1236|Gammaproteobacteria,2QC1M@267890|Shewanellaceae 1236|Gammaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_180019_2 1121035.AUCH01000015_gene2501 1.13e-25 108.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_180019_4 572477.Alvin_1103 2.81e-80 263.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_128862_1 1249627.D779_1247 4.28e-114 339.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1WW2I@135613|Chromatiales 135613|Chromatiales HL Thiamine monophosphate synthase - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,NUDIX_4,TMP-TENI k59_128862_2 1049564.TevJSym_aj00200 2.1e-197 557.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1J4SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_166642_1 1255043.TVNIR_2170 4.07e-107 318.0 COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Coenzyme F420-reducing hydrogenase, gamma subunit hoxY - - - - - - - - - - - Oxidored_q6 k59_4259_1 1304885.AUEY01000005_gene843 6.07e-97 298.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2MIJK@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_186947_2 1123020.AUIE01000041_gene3194 5.89e-14 70.1 2DN7J@1|root,32VZC@2|Bacteria,1N6CR@1224|Proteobacteria,1SAGW@1236|Gammaproteobacteria,1YGRC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_188954_3 756280.S0A145_9CAUD 6.93e-35 124.0 4QFDE@10239|Viruses,4QY4P@35237|dsDNA viruses no RNA stage,4QRGG@28883|Caudovirales,4QJUH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_188954_4 908819.A0A0A0YUX9_9CAUD 1.44e-182 528.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_188954_6 756280.M4PSK7_9CAUD 1.8e-28 107.0 4QGG7@10239|Viruses,4QXGW@35237|dsDNA viruses no RNA stage,4QSB4@28883|Caudovirales,4QIVB@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_188954_9 908819.A0A0A0YPN2_9CAUD 4.7e-28 116.0 4QB9S@10239|Viruses,4QUXK@35237|dsDNA viruses no RNA stage,4QPW1@28883|Caudovirales,4QIMD@10662|Myoviridae 10662|Myoviridae S Phage major capsid protein E - - - - - - - - - - - - - k59_175946_1 391615.ABSJ01000046_gene2084 1.44e-31 121.0 COG0438@1|root,COG0438@2|Bacteria,1NMB5@1224|Proteobacteria,1RYZ0@1236|Gammaproteobacteria,1J9R3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_175946_2 1123242.JH636435_gene3017 1.44e-31 129.0 COG3344@1|root,COG3344@2|Bacteria,2IZ3V@203682|Planctomycetes 203682|Planctomycetes L reverse transcriptase - - - - - - - - - - - - RVT_1 k59_78932_1 1049564.TevJSym_al00520 2.42e-111 332.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1J578@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG4591 ABC-type transport system, involved in lipoprotein release, permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_156523_2 1049564.TevJSym_as00660 3.51e-105 336.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_39848_1 882378.RBRH_04258 1.74e-63 209.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VKHY@28216|Betaproteobacteria,1JZQ8@119060|Burkholderiaceae 28216|Betaproteobacteria L Group II intron, maturase-specific domain - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1,RVT_N k59_65763_1 1121405.dsmv_0036 1.5e-130 397.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_72302_1 1265505.ATUG01000002_gene1766 4.02e-97 296.0 COG0069@1|root,COG1143@1|root,COG0069@2|Bacteria,COG1143@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,2MHXF@213118|Desulfobacterales 28221|Deltaproteobacteria E Conserved region in glutamate synthase - - - - - - - - - - - - Fer4,Glu_synthase k59_137068_1 1121935.AQXX01000085_gene5323 4.81e-89 272.0 COG1199@1|root,COG1199@2|Bacteria,1MWW0@1224|Proteobacteria,1RRFA@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL HELICc2 - - - - - - - - - - - - DEAD,Helicase_C_2,ResIII k59_137068_2 1034943.BN1094_03680 3.04e-108 328.0 COG4974@1|root,COG4974@2|Bacteria,1RBKD@1224|Proteobacteria,1S2H8@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_150140_1 335543.Sfum_0098 2.19e-96 305.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MQZP@213462|Syntrophobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_26952_2 1250232.JQNJ01000001_gene2894 1.04e-167 501.0 COG5525@1|root,COG5525@2|Bacteria 2|Bacteria S Phage terminase large subunit (GpA) gpA - 3.1.21.4 ko:K21512 - - - - ko00000,ko01000 - - - Terminase_GpA k59_137069_1 338963.Pcar_1084 7.83e-79 245.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_59339_1 706587.Desti_4443 2.58e-12 64.3 COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_98070_1 1249627.D779_3192 1.98e-32 119.0 COG3258@1|root,COG3258@2|Bacteria,1MZJW@1224|Proteobacteria,1S2EF@1236|Gammaproteobacteria,1WY2H@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_91672_1 765911.Thivi_0600 8.48e-79 252.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_39853_1 458817.Shal_3467 1.01e-49 172.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - iJN746.PP_2845 Amidohydro_1,Urease_alpha k59_39853_2 2340.JV46_28580 5.83e-44 144.0 COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,1S8UP@1236|Gammaproteobacteria,1J6HY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the urease beta subunit family ureB GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009039,GO:0016787,GO:0016810,GO:0016811 3.5.1.5 ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_1322,iECO103_1326.ECO103_3798,iECO111_1330.ECO111_1228,iECSP_1301.ECSP_1250,iECs_1301.ECs1323,iUMNK88_1353.UMNK88_1200,iZ_1308.Z1144,iZ_1308.Z1583 Urease_beta k59_130701_1 631362.Thi970DRAFT_04270 1.49e-52 186.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1WWEX@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_20328_1 32042.PstZobell_11349 8.35e-144 408.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_163045_1 1121440.AUMA01000008_gene880 1.4e-08 62.8 COG0457@1|root,COG0457@2|Bacteria,1MYZU@1224|Proteobacteria,42SNQ@68525|delta/epsilon subdivisions,2WPHI@28221|Deltaproteobacteria,2M842@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Tetratricopeptide - - - - - - - - - - - - OmpA,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_843_1 335543.Sfum_1173 3.55e-84 274.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_6,Pyr_redox_2 k59_85197_2 296591.Bpro_3784 1.11e-13 78.2 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,2VJP3@28216|Betaproteobacteria,4ABZR@80864|Comamonadaceae 28216|Betaproteobacteria S Head morphogenesis protein spp1 gp7 - - - - - - - - - - - - Phage_Mu_F k59_130706_1 1334046.AYTB01000020_gene618 0.000381 45.1 COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,4HGEK@91061|Bacilli,26G0S@186818|Planococcaceae 91061|Bacilli K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_33347_1 765913.ThidrDRAFT_3866 1.33e-107 318.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,1RNYE@1236|Gammaproteobacteria,1WW73@135613|Chromatiales 135613|Chromatiales S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_33347_4 713586.KB900536_gene2658 1.23e-136 399.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 135613|Chromatiales L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_33347_5 243233.MCA0119 4.41e-43 146.0 COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria,1SZ10@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_33347_6 768671.ThimaDRAFT_2761 1.52e-123 363.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,1RMPE@1236|Gammaproteobacteria,1WWMI@135613|Chromatiales 135613|Chromatiales O ADP-ribosyl-(Dinitrogen reductase) hydrolase - - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_33347_7 1249627.D779_0997 1.31e-63 203.0 2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,1RSEH@1236|Gammaproteobacteria,1WXNG@135613|Chromatiales 135613|Chromatiales S PFAM NifQ - - - ko:K15790 - - - - ko00000 - - - NifQ k59_33347_8 1229172.JQFA01000002_gene2556 7.99e-31 114.0 COG1393@1|root,COG1393@2|Bacteria,1G68J@1117|Cyanobacteria,1HB71@1150|Oscillatoriales 1117|Cyanobacteria P Belongs to the ArsC family - - - - - - - - - - - - ArsC k59_33347_9 857087.Metme_1622 4.14e-10 56.2 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1XGGR@135618|Methylococcales 135618|Methylococcales C PFAM 4Fe-4S ferredoxin, iron-sulphur binding, subgroup - - - - - - - - - - - - - k59_65770_2 1410620.SHLA_126c000070 6.88e-37 136.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U0JQ@28211|Alphaproteobacteria,4BCSI@82115|Rhizobiaceae 28211|Alphaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_91682_1 1191523.MROS_0823 1.48e-05 47.0 COG0834@1|root,COG0834@2|Bacteria 2|Bacteria ET amino acid transport artP - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_91682_2 1267535.KB906767_gene598 1.24e-75 237.0 COG1899@1|root,COG1899@2|Bacteria,3Y5EW@57723|Acidobacteria 57723|Acidobacteria O Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_143607_1 911239.CF149_07139 1.62e-13 71.6 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 ko:K00969,ko:K01488 ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340 M00115 R00137,R01560,R02556,R03005 RC00002,RC00477 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612 CTP_transf_like k59_59353_2 404589.Anae109_2479 1.8e-31 117.0 COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_143608_1 1304880.JAGB01000002_gene2153 9.96e-20 87.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia 186801|Clostridia K TIGRFAM RNA polymerase sigma factor, sigma-70 family algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_105176_2 1121920.AUAU01000017_gene1216 1.04e-40 143.0 COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria 57723|Acidobacteria Q Hypothetical methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_85798_1 439235.Dalk_0990 2.16e-82 258.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2WK22@28221|Deltaproteobacteria,2MI2Y@213118|Desulfobacterales 28221|Deltaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_34022_1 706587.Desti_4065 9.76e-124 374.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MQ7E@213462|Syntrophobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_66275_1 370438.PTH_0252 3.65e-54 179.0 COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,260CU@186807|Peptococcaceae 186801|Clostridia S TIGRFAM TIGR00268 family protein - - - ko:K06864 - - - - ko00000 - - - ATP_bind_3,Asn_synthase,NAD_synthase,QueC k59_59946_1 526222.Desal_0722 6.58e-63 198.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WK9D@28221|Deltaproteobacteria,2MG2J@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein frdB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2395 Fer2_3,Fer4_7,Fer4_8 k59_79666_1 765910.MARPU_03805 4.43e-95 279.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1WX2D@135613|Chromatiales 135613|Chromatiales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_79666_2 1049564.TevJSym_aa00200 2.8e-31 110.0 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,1J78G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Ribosomal protein L30p/L7e rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_195689_1 1123355.JHYO01000011_gene1491 6.86e-58 195.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,36XRE@31993|Methylocystaceae 28211|Alphaproteobacteria T Sigma-54 interaction domain flbD - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_157102_1 207559.Dde_0402 2.91e-70 227.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2M9AE@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585,ko:K18145,ko:K18295 ko01501,ko01503,map01501,map01503 M00639,M00646,M00647,M00649,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,2.A.6.2.40,8.A.1,8.A.1.6 - - Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23 k59_105181_1 1279017.AQYJ01000029_gene3960 9.59e-85 275.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_189681_2 1123257.AUFV01000003_gene1268 2.84e-110 324.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S3J8@1236|Gammaproteobacteria,1XC9E@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2238) - - - - - - - - - - - - DUF2238 k59_189681_3 1249627.D779_3936 4.26e-48 157.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1WX7S@135613|Chromatiales 135613|Chromatiales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_27511_1 316067.Geob_2894 6.43e-65 211.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,43TS7@69541|Desulfuromonadales 28221|Deltaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_124875_1 398767.Glov_2843 4.22e-98 298.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,43W3F@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_59952_1 568816.Acin_0781 3.89e-59 194.0 COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,4H22D@909932|Negativicutes 909932|Negativicutes G fructose-1,6-bisphosphatase glpX - 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_163636_1 177437.HRM2_24110 2.66e-102 300.0 COG0655@1|root,COG0655@2|Bacteria,1QF4Z@1224|Proteobacteria,42QAY@68525|delta/epsilon subdivisions,2WMME@28221|Deltaproteobacteria,2MKKG@213118|Desulfobacterales 28221|Deltaproteobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_21080_1 933262.AXAM01000014_gene275 6e-74 235.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_183254_1 991905.SL003B_1747 3.67e-08 51.6 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,4BR31@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Ribosomal L29 protein rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_183254_2 1121405.dsmv_3580 3.12e-36 124.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,42TNS@68525|delta/epsilon subdivisions,2WR6G@28221|Deltaproteobacteria,2MKWR@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_183254_3 933262.AXAM01000052_gene2000 1.13e-28 105.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2WNEK@28221|Deltaproteobacteria,2MJSK@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_79678_1 247490.KSU1_B0100 9.38e-62 203.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_21085_1 335543.Sfum_0020 5.58e-66 223.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_118434_4 243231.GSU0485 1.44e-21 96.7 COG3222@1|root,COG3222@2|Bacteria,1RHCP@1224|Proteobacteria,43B9I@68525|delta/epsilon subdivisions,2X6NN@28221|Deltaproteobacteria,43SK2@69541|Desulfuromonadales 28221|Deltaproteobacteria S Guanylyl transferase CofC like - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_131419_1 665959.HMPREF1013_01560 5.11e-21 94.4 COG0477@1|root,COG2814@2|Bacteria,1TQKU@1239|Firmicutes,4HA5Q@91061|Bacilli,1ZCSQ@1386|Bacillus 91061|Bacilli EGP COG0477 Permeases of the major facilitator superfamily yybF - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1,Sugar_tr k59_131419_2 1232683.ADIMK_0806 3.14e-121 356.0 COG0583@1|root,COG0583@2|Bacteria,1NUAB@1224|Proteobacteria,1RNYQ@1236|Gammaproteobacteria,46AV3@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_42081_1 981336.F944_01838 1.32e-55 196.0 COG0726@1|root,COG1649@1|root,COG0726@2|Bacteria,COG1649@2|Bacteria,1MWR2@1224|Proteobacteria,1RP7J@1236|Gammaproteobacteria,3NJCW@468|Moraxellaceae 1236|Gammaproteobacteria G Hypothetical glycosyl hydrolase family 13 - - - ko:K11931 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - GHL13,Polysacc_deac_1 k59_86959_1 1232437.KL662020_gene705 1.05e-42 152.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_35281_2 335543.Sfum_0683 4.96e-52 173.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2MQHH@213462|Syntrophobacterales 28221|Deltaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.21,5.4.99.22 ko:K06178,ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_15228_1 439235.Dalk_2844 1.84e-57 199.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MI3D@213118|Desulfobacterales 28221|Deltaproteobacteria L UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_184583_1 1167006.UWK_01424 5.54e-58 193.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM,DctQ k59_28626_1 485913.Krac_12422 2.26e-24 106.0 COG0466@1|root,COG0466@2|Bacteria,2G5TZ@200795|Chloroflexi 200795|Chloroflexi O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_54368_1 1169161.KB897738_gene2508 9.06e-38 140.0 COG0382@1|root,COG0382@2|Bacteria,2IDNB@201174|Actinobacteria 201174|Actinobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_138565_1 1449126.JQKL01000027_gene2473 4.12e-54 179.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,2689A@186813|unclassified Clostridiales 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_138565_2 526222.Desal_3326 4.23e-12 69.7 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R6F@68525|delta/epsilon subdivisions,2WN2B@28221|Deltaproteobacteria,2M95Y@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HD_5,Response_reg k59_119775_1 177437.HRM2_22100 1.04e-154 481.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_99615_1 590409.Dd586_0398 3.5e-89 276.0 COG0732@1|root,COG0732@2|Bacteria,1RHRY@1224|Proteobacteria,1S6NB@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_67568_1 314225.ELI_14900 2.25e-113 333.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_42094_1 339670.Bamb_0760 5.13e-69 218.0 COG0451@1|root,COG0451@2|Bacteria,1MVPZ@1224|Proteobacteria,2VM2A@28216|Betaproteobacteria,1K0S3@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM NAD-dependent epimerase dehydratase - - 1.1.1.135,1.1.1.281 ko:K15856,ko:K22252 ko00051,ko00520,map00051,map00520 - R03396,R03397,R03398,R03399 RC00182 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_2329_1 1121405.dsmv_2951 7.51e-105 317.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_86964_2 330214.NIDE3721 2.59e-32 129.0 COG1570@1|root,COG1570@2|Bacteria,3J0S9@40117|Nitrospirae 40117|Nitrospirae L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_158262_1 1121378.KB899742_gene3652 9.85e-65 214.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_177924_1 349521.HCH_00361 5.62e-21 95.1 COG1357@1|root,COG1357@2|Bacteria,1MWKD@1224|Proteobacteria,1RY8C@1236|Gammaproteobacteria,1XNMU@135619|Oceanospirillales 135619|Oceanospirillales S Ion channel - - - - - - - - - - - - Ion_trans_2,Pentapeptide k59_112969_1 187272.Mlg_1810 1.21e-74 238.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_73721_1 1049564.TevJSym_aa01860 4.59e-57 184.0 COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,1RQ35@1236|Gammaproteobacteria,1J69Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG1051 ADP-ribose pyrophosphatase nuhA - - - - - - - - - - - NUDIX k59_54373_2 1121878.AUGL01000010_gene1010 9.73e-82 249.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane yjdF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08984 - - - - ko00000 - - - DUF2238 k59_164645_1 768671.ThimaDRAFT_1375 3.59e-198 556.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales 135613|Chromatiales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_164645_2 351746.Pput_0440 8.04e-92 275.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1YW6H@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Nucleotidyl transferase - GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.99 ko:K00966,ko:K00992 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_164645_3 1049564.TevJSym_ao00610 1.03e-68 223.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1J4M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S glutamate--cysteine ligase ybdK_1 - - - - - - - - - - - GCS2 k59_99619_1 706587.Desti_4439 4.11e-14 69.3 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - - - - - - - - - - CBS k59_22385_1 1120951.AUBG01000013_gene2566 9.39e-75 239.0 COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,1HYXT@117743|Flavobacteriia 976|Bacteroidetes L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_132711_1 1190603.AJYD01000005_gene3879 1.81e-62 216.0 COG2199@1|root,COG2199@2|Bacteria,1R4JZ@1224|Proteobacteria,1RW5E@1236|Gammaproteobacteria,1XV6H@135623|Vibrionales 135623|Vibrionales T diguanylate cyclase - - 2.7.7.65 ko:K20961 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_80713_1 547045.NEISICOT_03211 2.88e-09 57.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,2KQ92@206351|Neisseriales 206351|Neisseriales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_80713_2 1049564.TevJSym_am00780 9.46e-121 352.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1J4QD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_80713_3 765913.ThidrDRAFT_0158 1.72e-109 332.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria,1WW66@135613|Chromatiales 135613|Chromatiales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_138573_1 933262.AXAM01000038_gene910 1.64e-28 112.0 COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,2MKUK@213118|Desulfobacterales 28221|Deltaproteobacteria S Sporulation and spore germination - - - - - - - - - - - - Germane k59_138573_2 525897.Dbac_1012 6.46e-25 96.3 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,42TVD@68525|delta/epsilon subdivisions,2WQPX@28221|Deltaproteobacteria,2MCIY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the bacterial histone-like protein family ihfB - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_171489_1 439235.Dalk_1358 1.59e-94 287.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,42MZM@68525|delta/epsilon subdivisions,2WJG6@28221|Deltaproteobacteria,2MJ01@213118|Desulfobacterales 28221|Deltaproteobacteria S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_196804_1 1049564.TevJSym_ao00620 2.27e-115 341.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1J622@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_93919_1 1163408.UU9_01849 2.04e-39 134.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1X6XR@135614|Xanthomonadales 135614|Xanthomonadales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_106544_1 933262.AXAM01000004_gene2399 2.53e-43 151.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2MIJI@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_106544_2 177437.HRM2_22130 9.55e-25 103.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MINS@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_42311_1 1121396.KB893100_gene4316 1.95e-86 286.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_80886_2 644282.Deba_3157 1.31e-34 124.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,42V63@68525|delta/epsilon subdivisions,2WQCH@28221|Deltaproteobacteria 28221|Deltaproteobacteria K TIGRFAM transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 k59_35485_1 1167006.UWK_00078 1.66e-100 303.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,42QX9@68525|delta/epsilon subdivisions,2WKS8@28221|Deltaproteobacteria,2MIGQ@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1 k59_178124_2 1034347.CAHJ01000066_gene2936 0.000158 47.4 COG1395@1|root,COG1395@2|Bacteria,1UY6T@1239|Firmicutes,4HB70@91061|Bacilli,1ZG6Q@1386|Bacillus 91061|Bacilli K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_178124_3 1123228.AUIH01000091_gene569 2.4e-56 197.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_94134_1 933262.AXAM01000017_gene3124 7.05e-69 233.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,2MINK@213118|Desulfobacterales 28221|Deltaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_184731_4 365044.Pnap_2191 4.05e-27 104.0 COG1733@1|root,COG1733@2|Bacteria,1QVH2@1224|Proteobacteria,2W49M@28216|Betaproteobacteria 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_34 k59_184731_5 765914.ThisiDRAFT_0072 2.77e-35 144.0 COG3307@1|root,COG3307@2|Bacteria,1RHTF@1224|Proteobacteria,1S83H@1236|Gammaproteobacteria,1WYR0@135613|Chromatiales 135613|Chromatiales M PFAM O-Antigen - - - - - - - - - - - - Wzy_C k59_119993_1 1049564.TevJSym_at00080 2.05e-96 311.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_158459_1 1121405.dsmv_0056 6.34e-55 181.0 COG1141@1|root,COG3383@1|root,COG1141@2|Bacteria,COG3383@2|Bacteria,1RAIK@1224|Proteobacteria,42SGD@68525|delta/epsilon subdivisions,2WP4S@28221|Deltaproteobacteria,2MJN9@213118|Desulfobacterales 28221|Deltaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_4,Fer4,Fer4_7 k59_196928_1 765911.Thivi_1774 1.07e-49 171.0 COG1527@1|root,COG1527@2|Bacteria,1R7PV@1224|Proteobacteria,1S0C2@1236|Gammaproteobacteria,1WWZK@135613|Chromatiales 135613|Chromatiales C (C AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_94135_1 386456.JQKN01000002_gene2833 9.17e-70 219.0 COG1926@1|root,arCOG00041@2157|Archaea,2XWHP@28890|Euryarchaeota 28890|Euryarchaeota F phosphoribosyltransferases prt - - - - - - - - - - - Pribosyltran k59_158460_1 880072.Desac_1429 1.65e-47 157.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MRHQ@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_73863_1 335543.Sfum_2563 6.59e-86 262.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria,2MQ9E@213462|Syntrophobacterales 28221|Deltaproteobacteria E Pterin binding enzyme - - 2.1.1.258 ko:K15023 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R02289,R10243 RC00004,RC00113,RC01144,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_48267_1 1122599.AUGR01000001_gene73 2.52e-54 176.0 2CYUJ@1|root,32T4V@2|Bacteria,1N05D@1224|Proteobacteria,1SAMI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3015) - - - - - - - - - - - - DUF3015 k59_48267_2 203122.Sde_3811 1.42e-96 311.0 28J7E@1|root,2Z92U@2|Bacteria,1NAE1@1224|Proteobacteria,1RRQ0@1236|Gammaproteobacteria,464R0@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_61335_1 1049564.TevJSym_bf00260 7.57e-191 556.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1J56J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Small-conductance mechanosensitive channel kefA GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K05802,ko:K22051 - - - - ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 - - MS_channel,MscS_TM,MscS_porin k59_184735_1 1121406.JAEX01000005_gene2868 2.39e-81 256.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2M856@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - - - - - - - - - - Peripla_BP_6 k59_158461_2 1121468.AUBR01000012_gene2601 2.21e-66 204.0 2F0YS@1|root,33U0E@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_119999_1 1232437.KL662015_gene1286 1.98e-29 115.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WK0K@28221|Deltaproteobacteria,2MIH5@213118|Desulfobacterales 28221|Deltaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_61338_1 639282.DEFDS_1357 1.61e-15 79.7 COG1649@1|root,COG1649@2|Bacteria,2GEW5@200930|Deferribacteres 200930|Deferribacteres S Hypothetical glycosyl hydrolase family 13 - - - ko:K11931 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - GHL13 k59_48271_1 1121479.AUBS01000001_gene3191 3.94e-61 202.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_132847_1 877418.ATWV01000002_gene1103 8.78e-10 62.0 COG0664@1|root,COG0664@2|Bacteria,2J8WG@203691|Spirochaetes 203691|Spirochaetes T Cyclic nucleotide binding domain protein - - - - - - - - - - - - cNMP_binding k59_158463_1 96561.Dole_3031 2.52e-52 178.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2MJFR@213118|Desulfobacterales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N k59_184743_1 1121013.P873_07315 7.85e-36 135.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RMUV@1236|Gammaproteobacteria,1XA5I@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_4 k59_191011_1 740709.A10D4_12669 4.52e-79 242.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,1RPEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L protein homolog of phage Mu protein gp30 - - - - - - - - - - - - Phage_Mu_F k59_9469_1 1121396.KB893054_gene2414 7.93e-90 278.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MIGA@213118|Desulfobacterales 28221|Deltaproteobacteria T CheY-like receiver, AAA-type ATPase, and DNA-binding - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_203815_1 1049564.TevJSym_ac00470 5.96e-46 149.0 COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,1SCWV@1236|Gammaproteobacteria,1J6VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S FlhB HrpN YscU SpaS Family flhB2 - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 k59_67784_1 207954.MED92_13593 2.2e-66 209.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,1S3XS@1236|Gammaproteobacteria,1XJRS@135619|Oceanospirillales 135619|Oceanospirillales E PFAM Lysine exporter protein (LYSE YGGA) - - - - - - - - - - - - LysE k59_67784_2 316057.RPD_4322 1.15e-78 252.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,3K4HM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C 4Fe-4S single cluster domain nirJ - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_67784_3 304371.MCP_2388 1.04e-50 181.0 COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2NAAK@224756|Methanomicrobia 224756|Methanomicrobia S radical SAM domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_67784_8 1249627.D779_3545 1.38e-93 287.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RZYT@1236|Gammaproteobacteria,1WY5J@135613|Chromatiales 135613|Chromatiales O Peptidase M48 - - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_164838_1 1288298.rosmuc_03047 1.67e-80 262.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,2TR0Y@28211|Alphaproteobacteria,46QGW@74030|Roseovarius 28211|Alphaproteobacteria S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_132849_2 631362.Thi970DRAFT_01591 3.18e-40 140.0 COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1S53U@1236|Gammaproteobacteria,1WXF9@135613|Chromatiales 135613|Chromatiales D Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_28787_1 933262.AXAM01000030_gene801 1.97e-67 217.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2WM7G@28221|Deltaproteobacteria,2MJ9U@213118|Desulfobacterales 28221|Deltaproteobacteria EGP PFAM nucleoside H symporter - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_54519_2 1397284.AYMN01000103_gene3863 2.06e-30 122.0 COG3209@1|root,COG4104@1|root,COG3209@2|Bacteria,COG4104@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,404A4@613|Serratia 1236|Gammaproteobacteria M RHS Repeat - - - - - - - - - - - - AHH,DUF4150,EndoU_bacteria,PAAR_motif,RHS,RHS_repeat,Tox-HNH-EHHH k59_67787_1 1117647.M5M_00830 3.1e-32 121.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,1JA3N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_106565_1 880072.Desac_2520 1.98e-34 132.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,43CRY@68525|delta/epsilon subdivisions,2X7ZI@28221|Deltaproteobacteria 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GAF,GGDEF k59_48280_1 439481.Aboo_1152 9.02e-68 213.0 COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota 28890|Euryarchaeota J eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA eif2a GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K03237 ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168 - - - ko00000,ko00001,ko03012 - - - EIF_2_alpha,S1 k59_48280_2 439481.Aboo_1153 6.72e-16 70.9 COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,3F2UF@33867|unclassified Euryarchaeota 28890|Euryarchaeota J Ribosomal protein S27 rps27e GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02978 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S27e k59_35496_1 243233.MCA0962 2.88e-86 281.0 2DSG4@1|root,32UT2@2|Bacteria,1N47W@1224|Proteobacteria,1SEA4@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - PMT_2 k59_35496_2 1120953.AUBH01000012_gene416 1.78e-22 92.8 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,467DX@72275|Alteromonadaceae 1236|Gammaproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_113098_1 886379.AEWI01000043_gene3322 6.62e-106 332.0 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,2G2VR@200643|Bacteroidia,3XJN8@558415|Marinilabiliaceae 976|Bacteroidetes IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897,ko:K18660 ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280,R03383 RC00004,RC00014,RC00137 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,PP-binding k59_166965_1 1232437.KL662042_gene2011 3.81e-92 278.0 COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42Y9C@68525|delta/epsilon subdivisions,2WUJJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_166968_1 314345.SPV1_10376 2.27e-48 176.0 COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,1NWNJ@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - 2.1.1.80,3.1.1.61 ko:K03406,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HWE_HK,HisKA_2,HisKA_3,PAS,PAS_10,PAS_3,PAS_4,PAS_9 k59_166975_2 1123368.AUIS01000006_gene513 3.73e-34 131.0 COG3598@1|root,COG3598@2|Bacteria,1QVDX@1224|Proteobacteria,1T5QV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25 k59_160894_1 3880.AES97356 0.000127 43.9 KOG4853@1|root,KOG4853@2759|Eukaryota,37UN2@33090|Viridiplantae,3GJA7@35493|Streptophyta 35493|Streptophyta S mitotic sister chromatid biorientation - - - - - - - - - - - - - k59_37920_1 1322246.BN4_10933 3.26e-40 148.0 COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria,1R9WW@1224|Proteobacteria,42R68@68525|delta/epsilon subdivisions,2WMSV@28221|Deltaproteobacteria,2M9QN@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - HATPase_c,Response_reg k59_45209_2 1215915.BN193_04125 2.99e-50 184.0 COG0688@1|root,COG0688@2|Bacteria 2|Bacteria I phosphatidylethanolamine metabolic process psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_70474_1 706587.Desti_2953 4.64e-111 332.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MEG@68525|delta/epsilon subdivisions,2WMGY@28221|Deltaproteobacteria,2MRER@213462|Syntrophobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_166989_1 933262.AXAM01000016_gene191 8.33e-79 241.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2WMG9@28221|Deltaproteobacteria,2MJCA@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the BI1 family ybhL - - ko:K06890,ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_166999_1 335543.Sfum_0062 1.81e-72 228.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2WJ3G@28221|Deltaproteobacteria,2MQ5Z@213462|Syntrophobacterales 28221|Deltaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 ko:K00611,ko:K09065 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01398,R07245 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_122699_2 292415.Tbd_1114 4.22e-161 461.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria 28216|Betaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_37945_1 1232437.KL661985_gene3582 4.16e-20 88.2 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,42PDT@68525|delta/epsilon subdivisions,2WKER@28221|Deltaproteobacteria,2MIIP@213118|Desulfobacterales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_37945_2 1121405.dsmv_3526 1.06e-116 339.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2MJ8F@213118|Desulfobacterales 28221|Deltaproteobacteria E ABC transporter - - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_63801_1 1121396.KB892913_gene116 1.81e-33 129.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales 28221|Deltaproteobacteria S Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_45227_3 1049564.TevJSym_al00440 1.46e-128 371.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1J5FQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iPC815.YPO1400,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770 CTP_transf_3 k59_45227_4 1283300.ATXB01000001_gene2456 1.09e-22 88.2 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,1SCFF@1236|Gammaproteobacteria,1XFSG@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_141076_1 1049564.TevJSym_aw00180 2.29e-81 241.0 COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1J6HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P conserved protein involved in intracellular sulfur reduction tusD GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019417,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07235 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE k59_141076_2 1049564.TevJSym_aw00190 1.3e-245 675.0 COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria 1224|Proteobacteria C TIGRFAM sulfite reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr k59_115401_2 1117319.PSPO_06238 2.66e-16 75.5 2E7CE@1|root,331VM@2|Bacteria,1N6U9@1224|Proteobacteria,1SDQ6@1236|Gammaproteobacteria,2Q4WZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_135068_1 472759.Nhal_0304 6.85e-71 226.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1WWIX@135613|Chromatiales 135613|Chromatiales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_129298_1 933262.AXAM01000014_gene285 6.12e-73 234.0 COG0237@1|root,COG2043@1|root,COG0237@2|Bacteria,COG2043@2|Bacteria,1RCXT@1224|Proteobacteria,42RI5@68525|delta/epsilon subdivisions,2WPDF@28221|Deltaproteobacteria,2MK2V@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_31126_2 397948.Cmaq_0432 3.46e-27 108.0 COG1082@1|root,arCOG01902@2157|Archaea 2157|Archaea G COG1082 Sugar phosphate isomerases epimerases - - - - - - - - - - - - AP_endonuc_2 k59_199276_1 1158760.AQXP01000038_gene426 1.04e-168 493.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_56480_1 1049564.TevJSym_ad01570 2.54e-58 194.0 2EC19@1|root,3360G@2|Bacteria,1PBYU@1224|Proteobacteria,1SD34@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidoglycan-binding protein, CsiV - - - - - - - - - - - - CsiV k59_56480_2 498211.CJA_1764 6.19e-28 114.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1FGID@10|Cellvibrio 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_25086_1 1121405.dsmv_2738 3.21e-89 281.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_17722_1 272624.lpg2421 5.22e-88 268.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,1JFMM@118969|Legionellales 118969|Legionellales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_187422_8 713586.KB900536_gene2105 1.36e-137 399.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1WX3Q@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_102234_2 335543.Sfum_0200 7.2e-98 287.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2MQDB@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_102234_3 335543.Sfum_0199 6.93e-49 159.0 COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2MQKR@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_63974_1 690850.Desaf_3306 2.83e-23 99.0 COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,430FR@68525|delta/epsilon subdivisions,2WVKI@28221|Deltaproteobacteria,2MFEK@213115|Desulfovibrionales 28221|Deltaproteobacteria L manually curated - - - - - - - - - - - - DDE_Tnp_1_2,DUF4096 k59_154257_1 379731.PST_2958 2.6e-67 235.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,1RMV2@1236|Gammaproteobacteria,1Z045@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_2,sCache_2 k59_38199_1 1031711.RSPO_c02508 9.01e-49 176.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,2VIPB@28216|Betaproteobacteria,1K5WQ@119060|Burkholderiaceae 28216|Betaproteobacteria S terminase GpA - - - - - - - - - - - - Terminase_GpA k59_129325_2 1049564.TevJSym_ao00260 1.31e-118 365.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1J4G3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_115412_1 1121405.dsmv_3781 1.58e-64 209.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_129330_1 595460.RRSWK_03372 1.34e-46 170.0 COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IZND@203682|Planctomycetes 203682|Planctomycetes K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_154266_1 349521.HCH_02206 1.01e-11 65.1 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1XN1Z@135619|Oceanospirillales 135619|Oceanospirillales E Required for the activity of the bacterial periplasmic transport system of putrescine potD - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 k59_154266_2 998088.B565_1936 1.91e-45 154.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,1Y5H5@135624|Aeromonadales 135624|Aeromonadales P Binding-protein-dependent transport system inner membrane component potC - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k59_180425_2 631362.Thi970DRAFT_04432 3.25e-85 266.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria,1X28U@135613|Chromatiales 135613|Chromatiales P Sodium/hydrogen exchanger family - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_187435_1 765914.ThisiDRAFT_1928 3.3e-64 221.0 COG0574@1|root,COG1080@1|root,COG1372@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,COG1372@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_161086_1 335543.Sfum_1934 4.24e-94 289.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MRG9@213462|Syntrophobacterales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_122949_1 1249480.B649_06955 9.97e-117 345.0 2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,42QE2@68525|delta/epsilon subdivisions,2YNKM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S 5'-nucleotidase - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase k59_56500_1 671143.DAMO_2373 2.98e-105 319.0 COG1012@1|root,COG1012@2|Bacteria,2NNW6@2323|unclassified Bacteria 2|Bacteria C Aldehyde dehydrogenase family - - 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_83206_1 177437.HRM2_44710 3.01e-19 94.4 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_12084_1 522772.Dacet_0259 7.41e-63 200.0 COG0279@1|root,COG0279@2|Bacteria,2GFD6@200930|Deferribacteres 200930|Deferribacteres G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_206062_1 1121405.dsmv_0595 8.22e-06 47.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MIT8@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_206062_2 933262.AXAM01000056_gene3171 4.35e-20 87.8 2ADFT@1|root,3135W@2|Bacteria,1MY8W@1224|Proteobacteria,42SW3@68525|delta/epsilon subdivisions,2WPYE@28221|Deltaproteobacteria,2MK86@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_25095_3 1049564.TevJSym_ab00750 5.85e-206 582.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine - - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_102245_1 326297.Sama_0621 9.52e-16 72.8 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,1S97W@1236|Gammaproteobacteria,2QEGI@267890|Shewanellaceae 1236|Gammaproteobacteria P COG0226 ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - PBP_like_2 k59_102245_2 95619.PM1_0208435 1.08e-59 214.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMV2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_2,sCache_2 k59_187442_1 323261.Noc_2931 1.53e-228 635.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,1RNYG@1236|Gammaproteobacteria,1WXYY@135613|Chromatiales 135613|Chromatiales S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_129340_1 56780.SYN_02895 1.91e-33 132.0 COG0457@1|root,COG1462@1|root,COG0457@2|Bacteria,COG1462@2|Bacteria,1N4V4@1224|Proteobacteria,42WHI@68525|delta/epsilon subdivisions,2WRYH@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG k59_83212_1 404589.Anae109_2549 3.99e-22 94.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WRZW@28221|Deltaproteobacteria,2YWS5@29|Myxococcales 28221|Deltaproteobacteria O Peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_83212_2 1232437.KL661978_gene3862 1.46e-10 61.6 COG0457@1|root,COG0457@2|Bacteria,1R438@1224|Proteobacteria,42PQ9@68525|delta/epsilon subdivisions,2WJ0C@28221|Deltaproteobacteria,2MIBG@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Tetratricopeptide - - - - - - - - - - - - TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_141335_1 986075.CathTA2_1600 4.88e-87 283.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli 91061|Bacilli EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_206068_1 105559.Nwat_0540 2.62e-81 254.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_4680_1 498761.HM1_2430 7.14e-21 96.7 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia 186801|Clostridia KLT Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_38250_2 42256.RradSPS_0599 6.34e-30 116.0 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr fabG4 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_56508_1 104623.Ser39006_02892 1.08e-33 120.0 COG3620@1|root,COG3620@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_31 k59_129355_1 1049564.TevJSym_at00620 1.14e-54 180.0 2C5U9@1|root,2Z9NJ@2|Bacteria,1R8VZ@1224|Proteobacteria,1RWKX@1236|Gammaproteobacteria,1J6WW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_38515_1 96561.Dole_2040 9.24e-65 213.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MIPJ@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_187670_1 933262.AXAM01000017_gene3141 3e-42 150.0 COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,2MI1V@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_173570_1 1238450.VIBNISOn1_500001 1.4e-65 215.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XTA5@135623|Vibrionales 135623|Vibrionales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_173572_1 1167006.UWK_02593 9.35e-64 201.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2WNBY@28221|Deltaproteobacteria,2MJMK@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM acetolactate synthase, small subunit ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_18041_1 1121405.dsmv_3105 3.81e-100 293.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2MJ0K@213118|Desulfobacterales 28221|Deltaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_56724_1 1177928.TH2_10614 7.06e-73 226.0 COG1100@1|root,COG1100@2|Bacteria,1N5QS@1224|Proteobacteria,2TSKW@28211|Alphaproteobacteria,2JVNE@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain - - - - - - - - - - - - AAA_24 k59_56724_2 1122201.AUAZ01000004_gene3444 3.79e-14 68.6 2AK7J@1|root,31AXS@2|Bacteria,1N2Y5@1224|Proteobacteria,1T0SE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_64209_1 237368.SCABRO_03027 9.12e-69 211.0 COG0426@1|root,COG0426@2|Bacteria 2|Bacteria C nitric oxide reductase activity dfa1 - - - - - - - - - - - Flavin_Reduct,Flavodoxin_1,Lactamase_B k59_51091_1 1123253.AUBD01000001_gene1477 2.06e-51 172.0 28H75@1|root,2Z7JG@2|Bacteria,1MU3Y@1224|Proteobacteria,1S198@1236|Gammaproteobacteria,1X4KF@135614|Xanthomonadales 135614|Xanthomonadales S Phage major capsid protein E - - - - - - - - - - - - Phage_cap_E k59_201990_2 706587.Desti_4261 2e-17 77.8 COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria 1224|Proteobacteria C PFAM methyl-viologen-reducing hydrogenase delta subunit - - 1.8.98.5,1.8.98.6 ko:K14127 ko00680,map00680 - R00019,R11943,R11944 RC00011 ko00000,ko00001,ko01000 - - - FlpD k59_201990_3 1232437.KL662031_gene2525 5.37e-05 42.0 COG1908@1|root,COG1908@2|Bacteria,1NFTQ@1224|Proteobacteria,42VFD@68525|delta/epsilon subdivisions,2WS6S@28221|Deltaproteobacteria,2MNVT@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_137060_1 1232410.KI421425_gene1553 3.15e-74 249.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_46235_1 1168065.DOK_15828 1.28e-12 67.0 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,1RMV0@1236|Gammaproteobacteria,1J5YV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_46235_2 1304878.AUGD01000004_gene5055 2.02e-16 86.3 COG2207@1|root,COG2207@2|Bacteria,1NFPK@1224|Proteobacteria,2U1I2@28211|Alphaproteobacteria,3JUC8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K AraC-binding-like domain - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_144348_2 335543.Sfum_2611 3.25e-46 151.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MRZS@213462|Syntrophobacterales 28221|Deltaproteobacteria K PFAM zinc finger, DksA TraR C4-type dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_105138_1 1121405.dsmv_2774 1.04e-248 700.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_137472_1 1479237.JMLY01000001_gene152 1.74e-94 280.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,465C4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_137472_2 765910.MARPU_09735 3.23e-115 344.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,1WWTJ@135613|Chromatiales 135613|Chromatiales P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_66235_1 933262.AXAM01000009_gene1481 9.31e-74 233.0 28MQN@1|root,2ZAZG@2|Bacteria,1MVVQ@1224|Proteobacteria,42MMM@68525|delta/epsilon subdivisions,2WKA1@28221|Deltaproteobacteria,2MHKP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_92353_1 1192759.AKIB01000037_gene3262 2.76e-74 240.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2JZZ6@204457|Sphingomonadales 204457|Sphingomonadales L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_46863_1 525897.Dbac_1841 2.8e-103 308.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_170309_1 1046625.AFQY01000002_gene1490 0.000491 47.4 2EB0E@1|root,33518@2|Bacteria,1NJRB@1224|Proteobacteria,1SHV6@1236|Gammaproteobacteria,3NN96@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628 k59_85759_1 270374.MELB17_14216 3.38e-36 126.0 COG3609@1|root,COG3609@2|Bacteria,1N9NJ@1224|Proteobacteria,1SCVS@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain parD - - ko:K07746 - - - - ko00000,ko02048 - - - ParD_antitoxin k59_85759_2 270374.MELB17_14211 6.8e-48 154.0 COG3668@1|root,COG3668@2|Bacteria,1N75M@1224|Proteobacteria,1S67C@1236|Gammaproteobacteria,467UK@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the RelE toxin family - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_85759_5 518637.EUBIFOR_02430 0.000502 48.5 COG3316@1|root,COG3316@2|Bacteria,1VZPC@1239|Firmicutes,3VUVM@526524|Erysipelotrichia 526524|Erysipelotrichia L Transposase C of IS166 homeodomain - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_27476_2 641491.DND132_1713 1.04e-42 171.0 COG2199@1|root,COG2199@2|Bacteria,1PG19@1224|Proteobacteria,43462@68525|delta/epsilon subdivisions,2X1V2@28221|Deltaproteobacteria,2MEWP@213115|Desulfovibrionales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_27476_4 323848.Nmul_A0080 3.06e-60 191.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,371R6@32003|Nitrosomonadales 28216|Betaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_21004_1 658187.LDG_5056 2.75e-88 264.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,1JCQG@118969|Legionellales 118969|Legionellales L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_21004_2 573370.DMR_02230 7.9e-31 115.0 COG0346@1|root,COG0346@2|Bacteria,1NNHK@1224|Proteobacteria,42XGG@68525|delta/epsilon subdivisions,2WXTY@28221|Deltaproteobacteria,2MBU7@213115|Desulfovibrionales 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_21004_3 220664.PFL_3153 7.26e-13 67.8 COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,1RYN3@1236|Gammaproteobacteria,1YN2W@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_111788_3 1134474.O59_000930 2.41e-138 405.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1FFRT@10|Cellvibrio 1236|Gammaproteobacteria L FES mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_111788_4 765911.Thivi_3750 2.65e-24 92.8 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales 135613|Chromatiales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_21006_1 335543.Sfum_0020 8.21e-65 219.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_92365_1 1232410.KI421422_gene2081 1.9e-46 170.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2X5K8@28221|Deltaproteobacteria,43SE1@69541|Desulfuromonadales 28221|Deltaproteobacteria O Collagenase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k59_72752_1 1097668.BYI23_A023020 3.85e-07 60.1 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,1JZPN@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.2.3 ko:K07812 - - - - ko00000,ko01000,ko02000 5.A.3.4 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_170324_1 1232437.KL661965_gene3274 4.89e-61 208.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42NE4@68525|delta/epsilon subdivisions,2WJX6@28221|Deltaproteobacteria,2MIJZ@213118|Desulfobacterales 28221|Deltaproteobacteria T Single cache domain 3 - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,sCache_3_2 k59_92372_1 391595.RLO149_c010850 5.45e-138 399.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2TT3J@28211|Alphaproteobacteria,2P3Y3@2433|Roseobacter 28211|Alphaproteobacteria S Fic/DOC family - - - - - - - - - - - - DUF977,Fic,HTH_24,HTH_DeoR,Penicillinase_R k59_150785_1 266265.Bxe_C0490 1.33e-42 152.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - Transposase_20 k59_111791_1 1123228.AUIH01000091_gene569 5.92e-62 217.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_111791_2 1123228.AUIH01000091_gene568 1.32e-60 198.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XHYC@135619|Oceanospirillales 135619|Oceanospirillales L recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_195681_1 626887.J057_14745 5.65e-13 67.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,465V8@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component urtE - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_195681_2 1249627.D779_3415 1.34e-26 104.0 COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,1RSB2@1236|Gammaproteobacteria,1WX39@135613|Chromatiales 135613|Chromatiales O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureD - - ko:K03190 - - - - ko00000 - - - UreD k59_59927_1 439235.Dalk_0458 1.39e-91 279.0 COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,2MI4Y@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT k59_27494_1 667014.Thein_0383 1.41e-51 169.0 COG1126@1|root,COG1126@2|Bacteria 2|Bacteria E abc transporter atp-binding protein - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_27494_2 459349.CLOAM1807 2.17e-26 106.0 COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria 2|Bacteria D MreB/Mbl protein mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_98556_1 335543.Sfum_1940 1.18e-93 276.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42R5T@68525|delta/epsilon subdivisions,2WMVQ@28221|Deltaproteobacteria,2MRW5@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_98556_2 1121405.dsmv_1989 6.96e-09 55.8 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MJHM@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_118405_1 264198.Reut_A0518 4.18e-57 188.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,1K2JZ@119060|Burkholderiaceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_46888_1 402777.KB235904_gene4117 2.92e-106 323.0 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1H97S@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_59928_1 485915.Dret_0844 4.88e-42 155.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,2M953@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM peptidase M48 Ste24p - - - - - - - - - - - iAF987.Gmet_1238 Peptidase_M48,TPR_14,TPR_16,TPR_19 k59_111795_1 589865.DaAHT2_2030 3.5e-53 186.0 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_72759_2 1232410.KI421424_gene1698 1.96e-58 197.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_53327_1 589865.DaAHT2_0507 1.39e-152 443.0 COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2MHXE@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_40592_1 243233.MCA1611 3.22e-33 121.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1SGJW@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_170340_1 879212.DespoDRAFT_00445 2.09e-35 141.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales 28221|Deltaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_8045_1 264202.CF0480 1.2e-18 86.3 COG1136@1|root,COG1136@2|Bacteria,2JFYR@204428|Chlamydiae 204428|Chlamydiae V system ATP-binding protein LolD lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_163618_1 1028801.RG1141_CH14500 1.89e-52 180.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,2TSG7@28211|Alphaproteobacteria,4B9J6@82115|Rhizobiaceae 28211|Alphaproteobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes sthA - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_163618_2 590998.Celf_2650 4.24e-07 52.4 COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4F0VR@85016|Cellulomonadaceae 201174|Actinobacteria S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_34017_2 1115515.EV102420_14_01240 1.68e-15 81.6 COG3299@1|root,COG3299@2|Bacteria,1MW2X@1224|Proteobacteria,1RP82@1236|Gammaproteobacteria 1236|Gammaproteobacteria S homolog of phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_92386_1 96561.Dole_2313 2.63e-53 186.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma-54 interaction domain - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_195683_1 485916.Dtox_0383 4.95e-08 64.7 COG5421@1|root,COG5421@2|Bacteria,1VWS6@1239|Firmicutes,251RQ@186801|Clostridia 186801|Clostridia L Domain of unknown function (DUF4277) - - - - - - - - - - - - DDE_Tnp_1,DUF4277 k59_124862_2 96561.Dole_1244 1.41e-23 101.0 COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42P9Y@68525|delta/epsilon subdivisions,2WM6A@28221|Deltaproteobacteria,2MJCC@213118|Desulfobacterales 28221|Deltaproteobacteria NTU General secretory system II protein E domain protein - - - - - - - - - - - - GAF,GAF_2,T2SSE,T2SSE_N k59_72763_1 2340.JV46_06460 2.22e-137 400.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1J4FX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECUMN_1333.ECUMN_0566,iJN746.PP_2905 DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_189676_1 335543.Sfum_3649 2.25e-117 355.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales 28221|Deltaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_144377_1 1049564.TevJSym_ae00420 1.18e-192 549.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1J57H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG2148 Sugar transferases involved in lipopolysaccharide synthesis lthA - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_144377_2 396588.Tgr7_2028 3.65e-142 420.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1WW9A@135613|Chromatiales 135613|Chromatiales G PFAM carbohydrate kinase - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_176593_1 1121405.dsmv_2750 1.73e-49 173.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Starch synthase catalytic - - 2.4.1.21,3.2.1.1 ko:K00703,ko:K01176 ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973 M00565 R02108,R02112,R02421,R11262 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GH13,GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_150801_1 1379281.AVAG01000001_gene268 1.53e-85 264.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42N47@68525|delta/epsilon subdivisions,2WIKZ@28221|Deltaproteobacteria,2M8JX@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD qrcD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_183239_1 1122132.AQYH01000010_gene3981 3.72e-23 96.3 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria,4B7N6@82115|Rhizobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_40603_1 335543.Sfum_1225 3.36e-97 313.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_189803_3 366394.Smed_3492 1.44e-13 69.7 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,4B7RM@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ dehydrogenase linC - - - - - - - - - - - adh_short_C2 k59_79804_1 1249627.D779_1001 2.51e-74 241.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWES@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_195813_1 1123228.AUIH01000010_gene3993 1.46e-24 105.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1XI78@135619|Oceanospirillales 135619|Oceanospirillales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_53475_2 1538295.JY96_10690 2.07e-29 124.0 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2VS1K@28216|Betaproteobacteria,1KNXI@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2169) - - - - - - - - - - - - DUF2169 k59_1500_2 1049564.TevJSym_be00080 7.7e-78 238.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1J4EE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_150956_1 177437.HRM2_47440 6.28e-110 346.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_8210_1 1123377.AUIV01000007_gene1343 5.01e-36 139.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1X3CZ@135614|Xanthomonadales 135614|Xanthomonadales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_118595_1 316067.Geob_2145 7.18e-141 421.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,43SZI@69541|Desulfuromonadales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_170491_1 1121918.ARWE01000001_gene1126 1.76e-74 236.0 COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42UZB@68525|delta/epsilon subdivisions,2WQSS@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_137617_3 1049564.TevJSym_bc00280 0.0 1026.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1J4UC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Domain of unknown function (DUF1974) fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_137617_4 1049564.TevJSym_bc00290 6.64e-18 83.2 28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,1S2DJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_183460_1 393595.ABO_2580 2.44e-59 195.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XH6E@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_146248_3 2340.JV46_05410 5.47e-251 703.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_146248_5 425104.Ssed_3244 2.36e-35 135.0 2C3X5@1|root,32RCX@2|Bacteria,1RKW4@1224|Proteobacteria,1S6V7@1236|Gammaproteobacteria,2QEHU@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_68521_1 396588.Tgr7_0080 1.03e-93 295.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_152513_1 506534.Rhein_3578 1.41e-15 80.9 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1WZAN@135613|Chromatiales 135613|Chromatiales L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_23105_1 1384049.CD29_11550 1.39e-59 194.0 COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,4HASG@91061|Bacilli,3IZAV@400634|Lysinibacillus 91061|Bacilli E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_87749_1 1318628.MARLIPOL_07989 4.65e-143 411.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,46517@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518 Chorismate_synt k59_87749_2 1179778.PMM47T1_09911 7.88e-21 91.7 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU type I secretion outer membrane protein, TolC tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_15944_1 177437.HRM2_07800 1.79e-78 246.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MKDA@213118|Desulfobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_15944_2 177439.DP0743 5.01e-07 51.2 COG0589@1|root,COG0589@2|Bacteria,1N5PT@1224|Proteobacteria,42UH3@68525|delta/epsilon subdivisions,2WR0A@28221|Deltaproteobacteria,2MKTU@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_36145_2 338969.Rfer_0255 1.23e-39 144.0 COG3303@1|root,COG3303@2|Bacteria,1NX4E@1224|Proteobacteria 1224|Proteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_36145_3 1049564.TevJSym_ao00560 6.08e-75 224.0 COG0727@1|root,COG0727@2|Bacteria,1NXZE@1224|Proteobacteria,1SQVM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_36145_4 1049564.TevJSym_ao00570 1.16e-34 131.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4U6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_159155_1 930169.B5T_03190 2.38e-06 53.5 COG4932@1|root,COG4932@2|Bacteria,1QVU9@1224|Proteobacteria 1224|Proteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD,REJ k59_68524_1 889378.Spiaf_2779 2.39e-31 122.0 COG0455@1|root,COG0455@2|Bacteria,2J5K5@203691|Spirochaetes 203691|Spirochaetes D ATP-binding protein ylxH-2 - - ko:K04562 - - - - ko00000,ko02035 - - - CbiA,ParA k59_68524_2 1121405.dsmv_0591 5.31e-24 99.4 COG0370@1|root,COG0370@2|Bacteria,1QWMI@1224|Proteobacteria,43BSF@68525|delta/epsilon subdivisions,2X739@28221|Deltaproteobacteria,2MI8F@213118|Desulfobacterales 28221|Deltaproteobacteria P Transporter of a GTP-driven Fe(2 ) uptake system - - - - - - - - - - - - - k59_3048_1 1049564.TevJSym_ah00850 1.15e-102 333.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_100440_1 1499967.BAYZ01000048_gene2713 1.45e-161 477.0 COG2103@1|root,COG2103@2|Bacteria,2NP6Y@2323|unclassified Bacteria 2|Bacteria S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 k59_165413_1 269799.Gmet_1952 4.38e-66 208.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,43UAM@69541|Desulfuromonadales 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_165413_2 1434929.X946_3446 2.61e-33 127.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,1K0GR@119060|Burkholderiaceae 28216|Betaproteobacteria M transglycosylase slt - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - SLT k59_139351_1 289376.THEYE_A1932 7.73e-61 195.0 COG0461@1|root,COG0461@2|Bacteria,3J0T8@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_159162_1 880072.Desac_0177 2.55e-65 211.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2MQ4M@213462|Syntrophobacterales 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_120711_1 933262.AXAM01000159_gene2160 5.92e-105 317.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria,2MIWB@213118|Desulfobacterales 28221|Deltaproteobacteria E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_15950_2 1304880.JAGB01000005_gene2444 1.09e-63 213.0 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia 186801|Clostridia S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_48962_1 75379.Tint_1668 4.89e-20 97.8 2E7PP@1|root,33259@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Acetyltransf_9 k59_48962_2 1158292.JPOE01000002_gene1573 3.22e-47 162.0 COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria 1224|Proteobacteria F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE GO:0003674,GO:0003824,GO:0003952,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0033554,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_1772,iSFV_1184.SFV_1480,iSF_1195.SF1486,iSFxv_1172.SFxv_1676,iS_1188.S1603 NAD_synthase k59_62116_2 743720.Psefu_4348 3.98e-13 70.1 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1YW8P@136845|Pseudomonas putida group 1236|Gammaproteobacteria K sigma-54 specific transcriptional regulator - - - ko:K11914,ko:K12266 ko05132,map05132 - - - ko00000,ko00001,ko02044,ko03000 - - - HTH_8,Sigma54_activat,V4R,XylR_N k59_127437_1 1121374.KB891578_gene3225 3.8e-81 257.0 28HNB@1|root,2Z7WM@2|Bacteria,1MWQ1@1224|Proteobacteria,1RZ55@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_100449_1 870187.Thini_0345 1.57e-39 133.0 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0125 (RnfH) family yfjF - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_10159_1 311424.DhcVS_455 1.33e-45 166.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2G6D3@200795|Chloroflexi,34CXX@301297|Dehalococcoidia 301297|Dehalococcoidia S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33 k59_191595_1 1163617.SCD_n01616 1.69e-16 82.0 COG1639@1|root,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD k59_191595_2 1049564.TevJSym_be00060 3.31e-66 206.0 COG0535@1|root,COG0535@2|Bacteria,1QUQ6@1224|Proteobacteria,1T20T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_14,Radical_SAM k59_107315_1 671143.DAMO_0837 4.74e-13 67.8 COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria 2|Bacteria S ABC-2 family transporter protein yxlG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_107315_2 203124.Tery_2807 1.76e-36 146.0 COG3225@1|root,COG3225@2|Bacteria,1G0JN@1117|Cyanobacteria,1H8SY@1150|Oscillatoriales 1117|Cyanobacteria N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux k59_113658_1 345341.KUTG_04234 4.98e-98 292.0 COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria 201174|Actinobacteria C aldo keto reductase - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red k59_185464_2 679926.Mpet_0922 4.96e-49 167.0 COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia 224756|Methanomicrobia S TIGRFAM small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_204390_1 439235.Dalk_4694 1.86e-34 130.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_204390_2 1472716.KBK24_0115835 1.97e-58 195.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,1K1XB@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.2,1.4.1.3 ko:K00260,ko:K00261 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_95020_1 665571.STHERM_c20760 3.29e-16 80.5 COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes 203691|Spirochaetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_62129_1 933262.AXAM01000017_gene3108 4.17e-74 231.0 COG1533@1|root,COG1533@2|Bacteria,1Q22I@1224|Proteobacteria,42SVJ@68525|delta/epsilon subdivisions,2WPAY@28221|Deltaproteobacteria,2MIXI@213118|Desulfobacterales 28221|Deltaproteobacteria L Domain of unknown function (DUF1848) - - - - - - - - - - - - DUF1848 k59_152529_1 1170562.Cal6303_0240 1.66e-109 335.0 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,1HU7J@1161|Nostocales 1117|Cyanobacteria L PFAM Transposase IS116 IS110 IS902 family - - - - - - - - - - - - Transposase_20 k59_120735_1 1121405.dsmv_3066 1.16e-90 297.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MHU0@213118|Desulfobacterales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_113662_1 396595.TK90_2071 3.23e-92 283.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_68537_1 1294143.H681_21940 3.9e-127 371.0 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,1RQ8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit vanA - 1.14.13.82 ko:K03862 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001,ko01000 - - - Rieske k59_48965_2 675813.VIB_000196 1.85e-34 122.0 COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,1SFHC@1236|Gammaproteobacteria,1Y280@135623|Vibrionales 1236|Gammaproteobacteria L IS66 Orf2 like protein - - - - - - - - - - - - TnpB_IS66 k59_48965_3 1121396.KB893122_gene3040 5.19e-34 131.0 COG4974@1|root,COG4974@2|Bacteria,1RC0C@1224|Proteobacteria,42W1W@68525|delta/epsilon subdivisions,2WRTZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66 k59_172090_1 1179778.PMM47T1_23457 3.43e-19 85.9 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,1RSR1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Phosphonate ABC transporter phnE_2 - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_172090_2 292415.Tbd_2299 6.48e-126 365.0 COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,2VIEZ@28216|Betaproteobacteria 28216|Betaproteobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_172090_3 395494.Galf_2741 1.63e-157 447.0 COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,2WEZY@28216|Betaproteobacteria 28216|Betaproteobacteria P Phosphonate ABC transporter - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_172090_4 1304883.KI912532_gene819 1.19e-125 363.0 COG2188@1|root,COG2188@2|Bacteria,1PH3E@1224|Proteobacteria,2W9F3@28216|Betaproteobacteria,2KZ8D@206389|Rhodocyclales 206389|Rhodocyclales K UTRA - - - - - - - - - - - - GntR,UTRA k59_172090_5 272123.Anacy_3528 7.66e-67 209.0 COG1943@1|root,COG1943@2|Bacteria,1G631@1117|Cyanobacteria,1HNBT@1161|Nostocales 1117|Cyanobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_172090_7 509191.AEDB02000019_gene4469 2.73e-19 92.8 COG0732@1|root,COG0732@2|Bacteria,1TT1D@1239|Firmicutes,24A13@186801|Clostridia,3WKZ8@541000|Ruminococcaceae 186801|Clostridia V Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_172090_8 395494.Galf_1432 0.0 1304.0 COG0210@1|root,COG0514@1|root,COG0847@1|root,COG0210@2|Bacteria,COG0514@2|Bacteria,COG0847@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,44VG6@713636|Nitrosomonadales 28216|Betaproteobacteria L DEAD DEAH box helicase domain protein - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,UvrD-helicase,UvrD_C k59_172090_9 1121405.dsmv_1789 1.64e-26 98.6 COG1813@1|root,COG1813@2|Bacteria,1N9TB@1224|Proteobacteria,42WF0@68525|delta/epsilon subdivisions,2WRSW@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 k59_172090_10 1121405.dsmv_1803 1.78e-47 154.0 2EB38@1|root,33540@2|Bacteria,1NBMZ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_172090_11 223926.28809857 0.000481 51.2 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1XVCX@135623|Vibrionales 135623|Vibrionales S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_19,TPR_2,VWA_2 k59_172090_12 1049564.TevJSym_bh00100 4.53e-59 194.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1J59K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_16,TPR_2,VWA_2 k59_36176_1 1107311.Q767_01615 3.38e-41 155.0 COG1520@1|root,COG3291@1|root,COG3386@1|root,COG5306@1|root,COG1520@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5306@2|Bacteria,4NNUN@976|Bacteroidetes,1IKME@117743|Flavobacteriia,2NXAD@237|Flavobacterium 976|Bacteroidetes G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - He_PIG,I-set,Ig_3,SBBP k59_74432_1 1121405.dsmv_3238 4.25e-80 251.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_152531_1 903818.KI912268_gene2303 2.86e-70 221.0 COG0667@1|root,COG0667@2|Bacteria,3Y2TA@57723|Acidobacteria 57723|Acidobacteria C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_29412_1 694427.Palpr_2928 2.43e-28 116.0 COG5557@1|root,COG5557@2|Bacteria,4NF8T@976|Bacteroidetes,2FW4G@200643|Bacteroidia 976|Bacteroidetes C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_10173_1 933262.AXAM01000062_gene941 2.27e-50 167.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMP4@28221|Deltaproteobacteria,2MJMR@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_10173_2 933262.AXAM01000055_gene1262 1.2e-30 118.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MJBU@213118|Desulfobacterales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_95027_1 106370.Francci3_4499 7.51e-05 48.1 COG0664@1|root,COG0664@2|Bacteria,2IRJW@201174|Actinobacteria,4EVPM@85013|Frankiales 201174|Actinobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_15975_1 1121935.AQXX01000141_gene2061 1.73e-13 72.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_191603_1 767434.Fraau_0746 8.64e-44 152.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1X49Q@135614|Xanthomonadales 135614|Xanthomonadales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_191603_3 1122164.JHWF01000033_gene2270 1.98e-10 60.5 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1JDAB@118969|Legionellales 118969|Legionellales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_95194_1 207559.Dde_1183 9.22e-135 390.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,43B4R@68525|delta/epsilon subdivisions,2X5VN@28221|Deltaproteobacteria,2MGWB@213115|Desulfovibrionales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_62310_1 631362.Thi970DRAFT_03858 1.92e-51 177.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_62310_2 1049564.TevJSym_an00600 1.2e-144 416.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_29556_1 32057.KB217483_gene9341 5.13e-64 211.0 28PII@1|root,2ZC8H@2|Bacteria,1G86U@1117|Cyanobacteria,1HU8G@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF4255) - - - - - - - - - - - - DUF4255 k59_159335_2 96561.Dole_2451 2.33e-52 175.0 COG2177@1|root,COG2177@2|Bacteria,1R85B@1224|Proteobacteria,42PXG@68525|delta/epsilon subdivisions,2WKX3@28221|Deltaproteobacteria,2MIBU@213118|Desulfobacterales 28221|Deltaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_185635_1 1249627.D779_3657 9.7e-113 339.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWWZ@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB k59_100541_2 1121918.ARWE01000001_gene831 9.07e-35 138.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42ZN4@68525|delta/epsilon subdivisions,2WV34@28221|Deltaproteobacteria,43VPK@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL k59_100541_4 864051.BurJ1DRAFT_4174 1.87e-07 60.8 COG3391@1|root,COG3391@2|Bacteria,1MYI5@1224|Proteobacteria,2VNCM@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM NHL repeat containing protein - - - - - - - - - - - - - k59_100541_5 748247.AZKH_0380 3.24e-37 155.0 COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria,2VMWI@28216|Betaproteobacteria 28216|Betaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_49112_1 1131269.AQVV01000020_gene2194 3.15e-102 305.0 COG0601@1|root,COG0601@2|Bacteria 2|Bacteria P nitrogen compound transport oppB - - ko:K02033,ko:K13894 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_146445_1 335543.Sfum_2525 4.97e-113 339.0 COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MQYD@213462|Syntrophobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_10315_1 1323663.AROI01000018_gene615 1.24e-97 301.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_10315_2 1049564.TevJSym_ac00790 8.02e-127 379.0 COG4191@1|root,COG4191@2|Bacteria,1QUWB@1224|Proteobacteria,1T23G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase fleS - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_8 k59_10315_3 1049564.TevJSym_ac00800 3.18e-44 156.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1J5J8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_120914_1 357276.EL88_09435 3.55e-07 57.0 COG5360@1|root,COG5360@2|Bacteria,4PMG6@976|Bacteroidetes,2G0C2@200643|Bacteroidia,4AV5K@815|Bacteroidaceae 976|Bacteroidetes S Heparinase II/III N-terminus - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_165573_2 1120951.AUBG01000017_gene3331 1.22e-09 57.4 2CCSR@1|root,32RWC@2|Bacteria,4NUMI@976|Bacteroidetes,1I452@117743|Flavobacteriia 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_70962_2 909663.KI867150_gene2148 2.41e-22 99.4 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales 28221|Deltaproteobacteria I BadF BadG BcrA BcrD - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_141595_2 1279009.ADICEAN_04250 5e-09 58.9 COG0457@1|root,COG0457@2|Bacteria,4NKK4@976|Bacteroidetes,47UDJ@768503|Cytophagia 976|Bacteroidetes S Anaphase-promoting complex, cyclosome, subunit 3 - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 k59_115738_1 330214.NIDE4257 7.27e-78 241.0 COG2084@1|root,COG2084@2|Bacteria,3J0R5@40117|Nitrospirae 40117|Nitrospirae I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_135458_2 525897.Dbac_1840 9.61e-85 267.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_148342_1 1123371.ATXH01000019_gene589 6.96e-67 209.0 COG0778@1|root,COG0778@2|Bacteria,2GHTQ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Putative TM nitroreductase - - - - - - - - - - - - Nitroreductase k59_89807_1 987059.RBXJA2T_08880 8.84e-37 134.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1KIWW@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_89807_2 1218074.BAXZ01000006_gene1835 1.2e-207 600.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,1K44Y@119060|Burkholderiaceae 28216|Betaproteobacteria I synthetase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_109568_1 580327.Tthe_1350 3.73e-31 119.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,42EKR@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_115742_2 765913.ThidrDRAFT_3558 6.91e-141 417.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_18127_6 1249627.D779_0846 2.49e-44 156.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_199760_1 247490.KSU1_B0541 1.58e-37 131.0 COG1238@1|root,COG1238@2|Bacteria,2J05B@203682|Planctomycetes 203682|Planctomycetes S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_199760_2 933262.AXAM01000107_gene1506 3.99e-76 232.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2MHNG@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_173745_1 640081.Dsui_1821 8.53e-52 177.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VSDG@28216|Betaproteobacteria,2KZ0E@206389|Rhodocyclales 206389|Rhodocyclales I Steryl acetyl hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_173745_2 288000.BBta_6644 3.23e-70 222.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TUMG@28211|Alphaproteobacteria,3JSTH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.90 ko:K00055 ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220 M00537,M00538 R01763,R02611,R04304,R05282,R05347,R05348 RC00087,RC00116 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_89925_1 177437.HRM2_43150 1.48e-40 141.0 COG3467@1|root,COG3467@2|Bacteria,1N4RH@1224|Proteobacteria,42TKQ@68525|delta/epsilon subdivisions,2WQ06@28221|Deltaproteobacteria,2MKN9@213118|Desulfobacterales 28221|Deltaproteobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_51328_1 95619.PM1_0213245 8.68e-60 201.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_51328_2 1196083.SALWKB12_0809 0.000311 42.7 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,2VJPQ@28216|Betaproteobacteria,2KR5U@206351|Neisseriales 206351|Neisseriales Q isochorismatase family - - - - - - - - - - - - DUF2322,Isochorismatase k59_187838_1 1323663.AROI01000002_gene1147 6.51e-68 227.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_64335_1 1463821.JOGR01000019_gene1150 9.08e-60 228.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4EY4M@85014|Glycomycetales 201174|Actinobacteria L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_64335_3 309798.COPRO5265_0458 3.83e-30 123.0 COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,42FGC@68295|Thermoanaerobacterales 186801|Clostridia L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_51332_1 264462.Bd0743 3.83e-24 100.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2MUR4@213481|Bdellovibrionales,2WQA9@28221|Deltaproteobacteria 213481|Bdellovibrionales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_5011_1 926550.CLDAP_15220 2.84e-115 343.0 COG2224@1|root,COG2224@2|Bacteria,2G61J@200795|Chloroflexi 200795|Chloroflexi C PFAM isocitrate lyase and phosphorylmutase - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_115857_1 1122164.JHWF01000006_gene265 1.4e-33 127.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1JDE3@118969|Legionellales 118969|Legionellales K ParB-like nuclease domain parB_1 - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_115857_2 399795.CtesDRAFT_PD3392 1.01e-63 209.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2VJP8@28216|Betaproteobacteria,4ACKH@80864|Comamonadaceae 28216|Betaproteobacteria S Gp37Gp68 family - - - - - - - - - - - - DUF5131 k59_115857_3 1049564.TevJSym_ac00860 3.08e-19 86.7 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_193542_1 1278309.KB907099_gene2913 1.88e-72 245.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - - k59_135601_1 765912.Thimo_0219 1.48e-73 235.0 COG0642@1|root,COG0642@2|Bacteria,1R514@1224|Proteobacteria,1T1FM@1236|Gammaproteobacteria,1WZCU@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA k59_51334_1 497965.Cyan7822_1129 1.69e-67 221.0 COG3385@1|root,COG3385@2|Bacteria,1GK9H@1117|Cyanobacteria,3KKFV@43988|Cyanothece 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - - k59_38713_3 754477.Q7C_2235 1.91e-24 95.9 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,46193@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_135605_1 396588.Tgr7_0387 5.57e-17 78.6 2DGRB@1|root,2ZX02@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_5014_1 1049564.TevJSym_bb00230 3.21e-87 286.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_109701_1 335543.Sfum_1754 5.5e-14 70.1 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MRMI@213462|Syntrophobacterales 28221|Deltaproteobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_109701_2 880072.Desac_0030 5.31e-62 201.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2MR9V@213462|Syntrophobacterales 28221|Deltaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_64356_1 1122194.AUHU01000003_gene2408 4.24e-96 307.0 COG3507@1|root,COG3693@1|root,COG5297@1|root,COG3507@2|Bacteria,COG3693@2|Bacteria,COG5297@2|Bacteria,1R7BZ@1224|Proteobacteria,1S17S@1236|Gammaproteobacteria,466TT@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 10 - - - - - - - - - - - - CBM_2,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_43 k59_187848_1 335543.Sfum_0901 6.56e-262 728.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2MRDP@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2638 PEPCK_C,PEPCK_N k59_167613_1 1304888.ATWF01000001_gene1863 1.93e-42 158.0 COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,2GFVU@200930|Deferribacteres 200930|Deferribacteres T Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - HATPase_c,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_76714_1 644282.Deba_0277 8.09e-107 318.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Cell shape determining protein MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_141715_1 977880.RALTA_B1385 3.96e-62 208.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,1K5EU@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_148449_1 556268.OFAG_00826 3.84e-07 60.8 2DB7C@1|root,2Z7KN@2|Bacteria,1N20J@1224|Proteobacteria,2VXDC@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_56954_1 335543.Sfum_0643 2.52e-114 340.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRH1@213462|Syntrophobacterales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_89937_2 748247.AZKH_4414 2.27e-269 769.0 COG2199@1|root,COG2200@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,2WHQZ@28216|Betaproteobacteria 28216|Betaproteobacteria T PAS fold-4 domain protein - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheR,EAL,GAF_2,GGDEF,PAS_10 k59_89937_4 234267.Acid_5903 3.38e-31 118.0 COG3437@1|root,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_89937_5 748247.AZKH_0040 2.93e-66 226.0 COG0642@1|root,COG0745@1|root,COG3850@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2W8YU@28216|Betaproteobacteria,2KXXB@206389|Rhodocyclales 206389|Rhodocyclales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_64361_1 1304883.KI912532_gene994 7.27e-130 372.0 COG2082@1|root,COG2082@2|Bacteria,1MX1E@1224|Proteobacteria,2VNZM@28216|Betaproteobacteria,2KUIA@206389|Rhodocyclales 206389|Rhodocyclales H Precorrin-8X methylmutase CbiC CobH - - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiC k59_64361_2 1304883.KI912532_gene995 8.33e-160 454.0 COG2138@1|root,COG2138@2|Bacteria,1PRGR@1224|Proteobacteria,2VIJJ@28216|Betaproteobacteria,2KU6G@206389|Rhodocyclales 206389|Rhodocyclales S CbiX - - 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiX k59_167619_1 1049564.TevJSym_ab00250 1.76e-211 595.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_18282_3 1049564.TevJSym_ac01780 7.46e-129 372.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1J4IP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_180851_1 335543.Sfum_0677 8.19e-85 267.0 COG5016@1|root,COG5016@2|Bacteria 2|Bacteria C pyruvate - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01958,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_18289_1 880072.Desac_0968 2.02e-47 162.0 COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42SR1@68525|delta/epsilon subdivisions,2WP5P@28221|Deltaproteobacteria,2MQKJ@213462|Syntrophobacterales 28221|Deltaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_109703_2 710111.FraQA3DRAFT_2512 5.32e-93 285.0 COG0702@1|root,COG0702@2|Bacteria,2GJB8@201174|Actinobacteria 201174|Actinobacteria GM PFAM NmrA family protein - - 1.6.5.2 ko:K19267 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - NAD_binding_10,NmrA k59_89952_1 880072.Desac_0835 7.63e-55 180.0 COG1908@1|root,COG2512@1|root,COG1908@2|Bacteria,COG2512@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria,2MRBM@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_89952_2 880072.Desac_0834 1.46e-87 285.0 COG1145@1|root,COG1148@1|root,COG1145@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQVU@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_51342_1 713586.KB900536_gene2656 4.65e-113 338.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales 135613|Chromatiales L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_102590_2 485916.Dtox_2444 1.02e-07 57.0 COG5482@1|root,COG5482@2|Bacteria 2|Bacteria S Putative PD-(D/E)XK phosphodiesterase (DUF2161) - - - - - - - - - - - - - k59_148469_2 439235.Dalk_2893 1.49e-13 71.6 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,42NM0@68525|delta/epsilon subdivisions,2WM96@28221|Deltaproteobacteria,2MHSQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_180858_1 1211844.CBLM010000097_gene2419 9.55e-07 53.1 COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V3SK@1239|Firmicutes,3VPDT@526524|Erysipelotrichia 526524|Erysipelotrichia H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,HD k59_180858_2 335541.Swol_1257 2.93e-24 102.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,42JKW@68298|Syntrophomonadaceae 186801|Clostridia S TIGRFAM competence damage-inducible protein CinA cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_56980_1 207559.Dde_0310 3.16e-83 265.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2M7SH@213115|Desulfovibrionales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,Voltage_CLC k59_167627_1 1049564.TevJSym_bf00110 1.29e-59 191.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter - - - - - - - - - - - - - k59_135633_1 1049564.TevJSym_ab00030 0.0 1033.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_141727_1 1049564.TevJSym_ap00560 1.3e-87 283.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1J62R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_38734_1 1122236.KB905141_gene896 2.3e-32 128.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VMQS@28216|Betaproteobacteria,2KKDD@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM extracellular solute-binding protein family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_193563_1 679926.Mpet_2542 1.73e-78 258.0 COG1032@1|root,arCOG01364@2157|Archaea,2XVND@28890|Euryarchaeota 28890|Euryarchaeota C PFAM Radical SAM superfamily - - - - - - - - - - - - B12-binding,Radical_SAM k59_193563_2 1282360.ABAC460_04280 6.63e-09 66.2 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2U0BU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Radical SAM - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_5411_1 349521.HCH_06293 6.57e-39 143.0 COG0583@1|root,COG0583@2|Bacteria,1MV06@1224|Proteobacteria,1RPI0@1236|Gammaproteobacteria,1XJDH@135619|Oceanospirillales 135619|Oceanospirillales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_12798_2 1121935.AQXX01000078_gene1563 5.99e-126 364.0 2FCD8@1|root,344GV@2|Bacteria,1P0UK@1224|Proteobacteria,1SS0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_12798_3 1123228.AUIH01000102_gene3067 3.08e-29 114.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,1RQQA@1236|Gammaproteobacteria,1XKYJ@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_51628_1 1049564.TevJSym_ba00350 1.2e-92 298.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_174145_1 314345.SPV1_05148 1.02e-46 157.0 COG3791@1|root,COG3791@2|Bacteria 2|Bacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_174145_3 1036674.A28LD_0215 8.32e-33 115.0 2E32V@1|root,32Y33@2|Bacteria,1N9B0@1224|Proteobacteria,1SCHJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_12799_1 1121405.dsmv_0270 1.13e-39 140.0 COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_51631_1 497964.CfE428DRAFT_1688 1.65e-22 105.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,46TV0@74201|Verrucomicrobia 74201|Verrucomicrobia T ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_20461_1 765913.ThidrDRAFT_2461 1.34e-08 51.6 2BF40@1|root,328W7@2|Bacteria,1QN5F@1224|Proteobacteria,1SGP3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3096) - - - - - - - - - - - - DUF3096 k59_20461_2 748247.AZKH_3408 1.16e-198 566.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,2KURS@206389|Rhodocyclales 206389|Rhodocyclales J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_20461_4 472759.Nhal_0207 2.76e-140 404.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_65840_1 765910.MARPU_04485 7.07e-53 180.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_65840_2 195250.CM001776_gene4027 1.56e-49 171.0 COG1156@1|root,COG1156@2|Bacteria,1G2WR@1117|Cyanobacteria,1H2M5@1129|Synechococcus 1117|Cyanobacteria C ATP synthase alpha/beta family, nucleotide-binding domain - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_33475_1 395493.BegalDRAFT_1007 4.81e-94 284.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,46075@72273|Thiotrichales 72273|Thiotrichales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_79090_1 572477.Alvin_3061 3.21e-94 292.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WX0J@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_79090_2 1249627.D779_0813 4.78e-167 479.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WWHS@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_79090_3 748247.AZKH_0601 6.47e-29 114.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,2VQCX@28216|Betaproteobacteria,2KYUF@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_117834_1 716928.AJQT01000047_gene2149 3.09e-80 254.0 COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VFE8@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 k59_150255_1 1100720.ALKN01000030_gene1023 2.2e-11 69.7 COG0823@1|root,COG3291@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria 1224|Proteobacteria U PKD domain-containing protein - - - - - - - - - - - - PKD,REJ k59_13873_1 768671.ThimaDRAFT_2669 3e-08 52.8 COG0790@1|root,COG0790@2|Bacteria,1N293@1224|Proteobacteria,1SBGP@1236|Gammaproteobacteria,1WYX5@135613|Chromatiales 135613|Chromatiales S Sel1-like repeats. - - - - - - - - - - - - Sel1 k59_104709_1 1278309.KB907099_gene2913 3.66e-65 225.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - - k59_7625_1 1304888.ATWF01000002_gene26 9.09e-34 125.0 COG0687@1|root,COG0687@2|Bacteria,2GFTA@200930|Deferribacteres 200930|Deferribacteres E Bacterial extracellular solute-binding protein - - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 k59_39967_1 1123368.AUIS01000006_gene528 1.27e-93 287.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,1RZZW@1236|Gammaproteobacteria,2NDK2@225057|Acidithiobacillales 225057|Acidithiobacillales OU Peptidase family S49 - - - - - - - - - - - - Peptidase_S49 k59_150259_1 933262.AXAM01000003_gene2792 1.72e-82 259.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_182701_1 335543.Sfum_1329 3.76e-71 233.0 COG0348@1|root,COG1143@1|root,COG1152@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1152@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2MSKF@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5,Fer4_7 k59_65847_1 1307761.L21SP2_2030 2.93e-17 84.3 COG3666@1|root,COG3666@2|Bacteria,2J98U@203691|Spirochaetes 203691|Spirochaetes L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_130820_4 1120963.KB894521_gene5 7.16e-23 103.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,2Q12A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_79094_1 1444310.JANV01000170_gene2322 9.68e-41 154.0 COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,4HYEG@91061|Bacilli 91061|Bacilli S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,zf-IS66 k59_79096_2 1335757.SPICUR_09435 2.18e-37 131.0 COG5002@1|root,COG5002@2|Bacteria,1R2EY@1224|Proteobacteria,1T5PC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - PAS_9 k59_13880_1 1049564.TevJSym_br00020 2.99e-105 338.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_195430_1 563192.HMPREF0179_01787 8.03e-48 158.0 COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2WPFW@28221|Deltaproteobacteria,2MB1T@213115|Desulfovibrionales 28221|Deltaproteobacteria FG PFAM Histidine triad (HIT) protein - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - CwfJ_C_1,HIT k59_85441_1 335543.Sfum_0379 4.86e-98 296.0 COG1541@1|root,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,2MRDJ@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_176189_1 765911.Thivi_3368 4.38e-140 422.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_176189_2 631362.Thi970DRAFT_03309 3e-157 445.0 COG0500@1|root,COG2226@2|Bacteria,1R5JA@1224|Proteobacteria,1T3U6@1236|Gammaproteobacteria,1X2Q2@135613|Chromatiales 135613|Chromatiales H Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family - - 2.1.1.156 ko:K18896 ko00260,map00260 - R10060 RC00003,RC03038 ko00000,ko00001,ko01000 - - - Methyltransf_25 k59_176189_3 1445613.JALM01000007_gene546 2.36e-62 207.0 COG0500@1|root,COG2230@1|root,COG2226@2|Bacteria,COG2230@2|Bacteria,2IAU4@201174|Actinobacteria,4E21M@85010|Pseudonocardiales 201174|Actinobacteria MQ PFAM Methyltransferase domain - - 2.1.1.156,2.1.1.157 ko:K18896,ko:K18897 ko00260,map00260 - R10060,R10061 RC00003,RC03038,RC03040 ko00000,ko00001,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_150421_1 1232437.KL661985_gene3569 7.74e-12 64.7 COG1456@1|root,COG1456@2|Bacteria,1RGBW@1224|Proteobacteria,42S7W@68525|delta/epsilon subdivisions,2WNEP@28221|Deltaproteobacteria,2MKAQ@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786 k59_202262_1 572479.Hprae_1407 3.52e-36 140.0 COG3385@1|root,COG3385@2|Bacteria,1TY08@1239|Firmicutes,24EQW@186801|Clostridia 186801|Clostridia L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_189264_2 1356854.N007_19580 8.95e-13 69.3 COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,4HDCK@91061|Bacilli 91061|Bacilli U AAA domain - - - - - - - - - - - - AAA_22,RuvB_N k59_91963_2 395494.Galf_0106 1.78e-90 275.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2VQ46@28216|Betaproteobacteria,44UYG@713636|Nitrosomonadales 28216|Betaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_118003_1 1049564.TevJSym_ai00520 8.63e-39 147.0 COG2199@1|root,COG4223@1|root,COG2199@2|Bacteria,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_118003_4 1049564.TevJSym_ai00470 1.47e-54 171.0 COG2920@1|root,COG2920@2|Bacteria,1RITK@1224|Proteobacteria,1S609@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_118003_6 1123279.ATUS01000001_gene2416 5.21e-28 119.0 COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,1RZN8@1236|Gammaproteobacteria,1J93K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Opacity family porin protein - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_118003_7 1120999.JONM01000001_gene1157 1.07e-42 149.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KQ47@206351|Neisseriales 28216|Betaproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_143897_1 572477.Alvin_1219 1.78e-84 267.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_143897_4 1158182.KB905022_gene979 1.89e-86 259.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1WWKA@135613|Chromatiales 135613|Chromatiales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_111453_1 1049564.TevJSym_aa01810 2.39e-121 365.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_111453_2 580332.Slit_1289 3.53e-121 393.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE2,HATPase_c,HisKA,Hpt,Response_reg k59_111453_3 977880.RALTA_B1642 1.15e-97 302.0 COG0535@1|root,COG0535@2|Bacteria,1R6IV@1224|Proteobacteria,2VZ7C@28216|Betaproteobacteria,1KCUU@119060|Burkholderiaceae 28216|Betaproteobacteria S radical SAM domain protein - - - - - - - - - - - - - k59_7732_1 96561.Dole_0572 4.31e-25 104.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MHRQ@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_182844_1 314278.NB231_08948 6.98e-44 155.0 COG1597@1|root,COG1597@2|Bacteria,1RIZ6@1224|Proteobacteria,1S4KN@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_53089_1 1117319.PSPO_09964 2.69e-64 221.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q1ZW@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_163271_1 517418.Ctha_2533 2.3e-48 175.0 COG0653@1|root,COG0653@2|Bacteria,1FDBP@1090|Chlorobi 1090|Chlorobi U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_156767_1 96561.Dole_2758 1.01e-38 139.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,2MKHT@213118|Desulfobacterales 28221|Deltaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_13983_1 883.DvMF_1772 3.51e-13 66.2 COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria,2MH8W@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_13983_2 289376.THEYE_A0734 3.89e-49 161.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - Response_reg k59_85449_1 391596.PBAL39_18944 4.88e-42 151.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity - - - - - - - - - - - - DUF2974,DUF308 k59_85449_2 1499498.EV05_0886 8.32e-17 77.4 COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,1MKY5@1212|Prochloraceae 1117|Cyanobacteria F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_1036_1 1396141.BATP01000014_gene2731 1.75e-08 59.3 COG1539@1|root,COG1539@2|Bacteria,46VUG@74201|Verrucomicrobia,2IW51@203494|Verrucomicrobiae 203494|Verrucomicrobiae H Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_46528_1 335543.Sfum_1176 1.72e-102 307.0 COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 k59_189274_1 1116472.MGMO_49c00110 4.08e-09 58.9 COG3065@1|root,COG3065@2|Bacteria,1MZ8C@1224|Proteobacteria,1S9UB@1236|Gammaproteobacteria,1XFU8@135618|Methylococcales 135618|Methylococcales M Outer membrane lipoprotein Slp - - - ko:K07285 - - - - ko00000 - - - Slp k59_176197_1 870187.Thini_4414 7.71e-210 587.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_176197_2 768671.ThimaDRAFT_3597 3.1e-88 267.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1WW3I@135613|Chromatiales 135613|Chromatiales C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_150438_1 177437.HRM2_42130 3.46e-45 150.0 COG2944@1|root,COG2944@2|Bacteria,1N66H@1224|Proteobacteria,42UQW@68525|delta/epsilon subdivisions,2WQQF@28221|Deltaproteobacteria,2MKNP@213118|Desulfobacterales 28221|Deltaproteobacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_13986_2 1232437.KL662064_gene4060 8.73e-20 83.2 COG1917@1|root,COG1917@2|Bacteria,1N13F@1224|Proteobacteria,43BFG@68525|delta/epsilon subdivisions,2X6TV@28221|Deltaproteobacteria,2MKJZ@213118|Desulfobacterales 28221|Deltaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_202271_2 1192034.CAP_3197 2.24e-113 367.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,43C78@68525|delta/epsilon subdivisions,2WTIJ@28221|Deltaproteobacteria,2YYA7@29|Myxococcales 28221|Deltaproteobacteria Q PKS_DH - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_150439_1 439235.Dalk_4515 3.57e-65 216.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_33636_1 933262.AXAM01000001_gene361 6.89e-77 244.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MIA5@213118|Desulfobacterales 28221|Deltaproteobacteria L AAA ATPase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_91970_1 1168067.JAGP01000001_gene464 2.15e-44 154.0 COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,1T2CN@1236|Gammaproteobacteria,461HV@72273|Thiotrichales 72273|Thiotrichales S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_91970_2 760154.Sulba_2247 3.4e-31 115.0 2E65Y@1|root,330UM@2|Bacteria,1N8U3@1224|Proteobacteria,42VZJ@68525|delta/epsilon subdivisions,2YSEQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_91970_3 765913.ThidrDRAFT_3300 1.08e-36 135.0 COG1434@1|root,COG1434@2|Bacteria,1N8RS@1224|Proteobacteria,1SDWN@1236|Gammaproteobacteria,1WZ8P@135613|Chromatiales 135613|Chromatiales S DUF218 domain - - - - - - - - - - - - DUF218 k59_91970_4 977880.RALTA_B2238 1.47e-85 270.0 COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,2VH6J@28216|Betaproteobacteria,1K35D@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM monooxygenase FAD-binding - - - - - - - - - - - - Trp_halogenase k59_169895_1 1120936.KB907226_gene2819 5.57e-12 72.4 COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4EHAT@85012|Streptosporangiales 201174|Actinobacteria L RecG wedge domain recG GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon k59_104853_1 880071.Fleli_2325 8.17e-11 66.6 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes,47TCB@768503|Cytophagia 976|Bacteroidetes L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_104853_2 653045.Strvi_5955 1.55e-08 60.8 COG1846@1|root,COG1940@1|root,COG3415@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,COG3415@2|Bacteria,2GIU4@201174|Actinobacteria 201174|Actinobacteria GK ROK family - - - - - - - - - - - - HTH_23,HTH_29,MarR_2,ROK k59_176200_1 439235.Dalk_3072 2.98e-132 385.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,42NJ3@68525|delta/epsilon subdivisions,2WKHX@28221|Deltaproteobacteria,2MMT7@213118|Desulfobacterales 28221|Deltaproteobacteria O Uncharacterized protein family (UPF0051) - - - ko:K07033 - - - - ko00000 - - - UPF0051 k59_158168_1 335543.Sfum_0262 7.31e-15 72.4 COG0789@1|root,COG0789@2|Bacteria,1Q2SA@1224|Proteobacteria,438DW@68525|delta/epsilon subdivisions,2WXRH@28221|Deltaproteobacteria 28221|Deltaproteobacteria K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_2 k59_158168_2 1184609.KILIM_018_00260 8.9e-13 67.0 COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4F63W@85018|Dermatophilaceae 201174|Actinobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB2 - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_41995_1 765912.Thimo_2172 1.47e-122 357.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_93781_1 1232437.KL662036_gene2708 1.46e-46 153.0 COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria,2MK6D@213118|Desulfobacterales 28221|Deltaproteobacteria P Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_184497_1 408672.NBCG_01888 1.97e-14 72.8 COG0265@1|root,COG0265@2|Bacteria,2ICC4@201174|Actinobacteria 201174|Actinobacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - - k59_54292_1 56780.SYN_02863 5.24e-56 186.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,2MRJ5@213462|Syntrophobacterales 28221|Deltaproteobacteria F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_2269_1 1487923.DP73_08305 4.69e-50 177.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1UT78@1239|Firmicutes,24A6H@186801|Clostridia,26171@186807|Peptococcaceae 186801|Clostridia C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,Fer4_9,FlpD,Pyr_redox_2 k59_2269_2 1121428.DESHY_20175___1 8.42e-21 92.0 COG1148@1|root,COG1148@2|Bacteria,1TS8Y@1239|Firmicutes,24CXD@186801|Clostridia,2604G@186807|Peptococcaceae 186801|Clostridia C binding domain - - - ko:K16885 - - - - ko00000 - - - FAD_oxidored,Fer4,Fer4_10,Fer4_7,Fer4_9,NAD_binding_8,Pyr_redox_2 k59_28545_5 113355.CM001775_gene1785 2.72e-09 62.8 COG0652@1|root,COG2931@1|root,COG0652@2|Bacteria,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria 1117|Cyanobacteria Q Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - He_PIG,HemolysinCabind,Peptidase_M10_C k59_99530_1 378806.STAUR_4212 4.4e-30 126.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2WPVT@28221|Deltaproteobacteria,2YV10@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_106241_1 391896.A1I_06545 1.53e-48 166.0 COG2250@1|root,COG2250@2|Bacteria,1QYVH@1224|Proteobacteria,2TXZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S HEPN domain - - - - - - - - - - - - HEPN k59_190733_1 1121405.dsmv_2076 2.23e-31 117.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,42QPA@68525|delta/epsilon subdivisions,2WMPU@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_42000_1 1049564.TevJSym_ad01620 8.44e-199 569.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_9226_1 1120985.AUMI01000011_gene175 5.72e-98 300.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4H2A5@909932|Negativicutes 909932|Negativicutes E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 k59_203580_1 553204.CORAM0001_0500 2.05e-29 120.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,22M0N@1653|Corynebacteriaceae 201174|Actinobacteria C FAD linked oxidases, C-terminal domain eapA - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_2272_1 1266914.ATUK01000010_gene1148 1.38e-14 79.7 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1X2AP@135613|Chromatiales 135613|Chromatiales T Protein tyrosine kinase - - - - - - - - - - - - GAF,HDOD,Pkinase k59_2272_2 933262.AXAM01000049_gene3259 1.38e-13 69.7 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_99533_1 641491.DND132_1543 1.21e-62 203.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2M7R3@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_99533_2 1121405.dsmv_0145 7.48e-52 173.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2MJB7@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_184505_1 237368.SCABRO_03655 3.25e-12 63.5 COG3668@1|root,COG3668@2|Bacteria,2J4NM@203682|Planctomycetes 203682|Planctomycetes S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_80636_2 1049564.TevJSym_af00750 7.88e-43 155.0 COG1538@1|root,COG1538@2|Bacteria,1RDNB@1224|Proteobacteria,1S535@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_86892_1 1049564.TevJSym_bu00040 1.02e-128 401.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_42006_1 1121403.AUCV01000069_gene2314 1.06e-16 83.6 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WIRT@28221|Deltaproteobacteria,2MMKZ@213118|Desulfobacterales 28221|Deltaproteobacteria T Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_203583_1 1121403.AUCV01000013_gene3954 4.59e-94 303.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MHXW@213118|Desulfobacterales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_99534_2 313606.M23134_02290 2.61e-62 210.0 COG2303@1|root,COG2303@2|Bacteria,4NIU5@976|Bacteroidetes,47RDM@768503|Cytophagia 976|Bacteroidetes E GMC oxidoreductase - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_196741_1 56780.SYN_00187 6.32e-12 71.2 COG0810@1|root,COG0810@2|Bacteria,1Q5Z4@1224|Proteobacteria,43A9M@68525|delta/epsilon subdivisions,2X230@28221|Deltaproteobacteria,2MQPN@213462|Syntrophobacterales 28221|Deltaproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 k59_119675_3 84531.JMTZ01000020_gene3681 2.23e-12 67.4 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1X3JD@135614|Xanthomonadales 135614|Xanthomonadales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_67464_1 933262.AXAM01000038_gene909 7.98e-145 429.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2MIK2@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA-2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_138495_1 706587.Desti_4995 6.65e-58 194.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42KZ5@68525|delta/epsilon subdivisions,2WKK2@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM AMP-dependent synthetase and ligase - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_177854_1 1396858.Q666_11620 6.85e-256 716.0 COG0210@1|root,COG0210@2|Bacteria,1NBQK@1224|Proteobacteria,1S0VR@1236|Gammaproteobacteria,469DS@72275|Alteromonadaceae 1236|Gammaproteobacteria L UvrD-like helicase C-terminal domain - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_67470_1 933262.AXAM01000038_gene916 3.2e-33 129.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,2MI2N@213118|Desulfobacterales 28221|Deltaproteobacteria S SpoVR like protein spoVR - - ko:K06415 - - - - ko00000 - - - SpoVR k59_203586_1 1521187.JPIM01000024_gene697 8.72e-113 345.0 COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,376GY@32061|Chloroflexia 32061|Chloroflexia IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_35220_1 335543.Sfum_3743 2.8e-83 260.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2MQRN@213462|Syntrophobacterales 28221|Deltaproteobacteria M TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_9237_1 1287116.X734_00310 4.7e-51 171.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2TT3J@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Filamentation induced by cAMP protein fic - - - - - - - - - - - - DUF977,Fic,HTH_24,HTH_DeoR,Penicillinase_R k59_86903_1 768671.ThimaDRAFT_3100 2.65e-66 208.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1RMKG@1236|Gammaproteobacteria,1X24U@135613|Chromatiales 135613|Chromatiales G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_138497_1 1317124.DW2_10069 1.84e-26 111.0 COG5545@1|root,COG5545@2|Bacteria,1MVGK@1224|Proteobacteria,2U0ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria L virulence-associated E family protein - - - - - - - - - - - - Prim-Pol,Toprim_3,VirE k59_184509_1 765911.Thivi_0738 2.2e-78 259.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_184509_2 1049564.TevJSym_bj00110 6.01e-197 548.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1J51I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394 Aminotran_4 k59_132755_1 933262.AXAM01000008_gene1922 6.97e-99 307.0 COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MHPT@213118|Desulfobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_196822_2 909943.HIMB100_00018030 6.71e-20 89.4 2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2U7X0@28211|Alphaproteobacteria,4BSCS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2889) - - - - - - - - - - - - DUF2889 k59_196822_3 1225184.ALXE01000017_gene3697 8.74e-128 380.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_87029_1 572479.Hprae_1121 1.1e-59 203.0 COG2204@1|root,COG5564@1|root,COG2204@2|Bacteria,COG5564@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia 186801|Clostridia T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,PEP_hydrolase,Response_reg,Sigma54_activat k59_61238_1 880072.Desac_0826 2.36e-100 306.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_151938_1 1121935.AQXX01000102_gene1330 5.26e-75 256.0 COG3451@1|root,COG3451@2|Bacteria,1MUEN@1224|Proteobacteria,1RPAY@1236|Gammaproteobacteria 1236|Gammaproteobacteria U type IV secretory pathway, VirB4 components - - - - - - - - - - - - DUF87,TraC_F_IV k59_151938_3 1051646.VITU9109_10402 3.58e-41 161.0 COG3064@1|root,COG3064@2|Bacteria,1MXIR@1224|Proteobacteria,1T1FI@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Integrating conjugative element protein - - - - - - - - - - - - - k59_113021_2 768671.ThimaDRAFT_1263 8.91e-69 217.0 28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,1RNYB@1236|Gammaproteobacteria,1WW5I@135613|Chromatiales 135613|Chromatiales H PFAM Dinitrogenase reductase ADP-ribosyltransferase - - 2.4.2.37 ko:K05951 - - - - ko00000,ko01000 - - - DRAT k59_132756_1 1049564.TevJSym_bn00140 2.59e-155 449.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1J8GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Amidohydrolase family pyrC - 3.5.2.3,3.5.2.5 ko:K01465,ko:K01466 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00051,M00546 R01993,R02425 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_94010_1 243233.MCA2070 2.18e-32 140.0 COG2202@1|root,COG2203@1|root,COG2206@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3829@2|Bacteria,1RAQS@1224|Proteobacteria,1T3FU@1236|Gammaproteobacteria 1236|Gammaproteobacteria T HD domain - - - - - - - - - - - - HD,HD_5 k59_42197_1 1294143.H681_14985 5.46e-11 61.6 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria K response regulator - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_178006_2 880072.Desac_2716 2.73e-57 183.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,42SCN@68525|delta/epsilon subdivisions,2WP3E@28221|Deltaproteobacteria,2MQIG@213462|Syntrophobacterales 28221|Deltaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_119859_1 395493.BegalDRAFT_0782 9.64e-41 141.0 COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria,1S8SN@1236|Gammaproteobacteria 1236|Gammaproteobacteria K regulatory protein TetR - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_119859_3 743719.PaelaDRAFT_0264 2.32e-34 128.0 COG1595@1|root,COG1595@2|Bacteria,1V3G9@1239|Firmicutes,4I977@91061|Bacilli,2714A@186822|Paenibacillaceae 91061|Bacilli K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_119859_5 1209989.TepiRe1_2467 2.11e-44 153.0 COG1695@1|root,COG1695@2|Bacteria,1V1YA@1239|Firmicutes,24H08@186801|Clostridia,42GPY@68295|Thermoanaerobacterales 186801|Clostridia K Domain of unknown function (DUF2703) - - - - - - - - - - - - DUF2703 k59_119859_6 1049564.TevJSym_bm00210 1.4e-40 139.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_35364_1 1041146.ATZB01000109_gene4395 7.33e-54 181.0 COG4469@1|root,COG4469@2|Bacteria,1N4GZ@1224|Proteobacteria,2UE2H@28211|Alphaproteobacteria,4BK4G@82115|Rhizobiaceae 28211|Alphaproteobacteria S COG4469 Competence protein - - - - - - - - - - - - CoiA k59_73769_1 1249627.D779_3659 5.76e-97 285.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RZY6@1236|Gammaproteobacteria,1WX9M@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_184658_1 999541.bgla_1g03980 3.99e-73 230.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,1K4RQ@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_67685_1 880072.Desac_1556 2.7e-62 209.0 COG0151@1|root,COG0151@2|Bacteria,1NTMF@1224|Proteobacteria,42YB9@68525|delta/epsilon subdivisions,2WTMZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A k59_9352_1 1049564.TevJSym_ba00180 5.67e-77 237.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1J4Y4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_9352_2 1049564.TevJSym_ba00190 6.85e-153 432.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1J5AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_54449_1 1366050.N234_01100 1.98e-76 238.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,1K28G@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran k59_164733_1 1049564.TevJSym_bh00220 4.49e-97 285.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1J4UQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0131 Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_164733_2 1049564.TevJSym_bh00230 6.92e-26 100.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1J5UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_151944_1 1049564.TevJSym_ag00700 4.73e-103 300.0 COG1150@1|root,COG1150@2|Bacteria,1RHH3@1224|Proteobacteria,1S0VG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_8 k59_151944_2 1049564.TevJSym_ag00690 3.33e-94 295.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,1S0DI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 k59_145550_1 1048834.TC41_0415 4.46e-25 108.0 COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,4HDFR@91061|Bacilli 91061|Bacilli L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_2398_1 391625.PPSIR1_15410 1.21e-20 96.7 COG0300@1|root,COG3321@1|root,COG0300@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria 1224|Proteobacteria Q polyketide synthase - - - ko:K16396,ko:K16397,ko:K16398 ko01052,map01052 - - - ko00000,ko00001 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_203728_1 1121405.dsmv_1440 3.4e-65 217.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM ribonuclease II - - 3.1.13.1 ko:K01147,ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_119872_1 1283300.ATXB01000001_gene1388 2.27e-57 194.0 COG2204@1|root,COG2836@1|root,COG2204@2|Bacteria,COG2836@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XH0X@135618|Methylococcales 135618|Methylococcales T AAA domain (Cdc48 subfamily) - - - - - - - - - - - - HTH_8,Sigma54_activat k59_36664_1 95619.PM1_0206655 1.05e-35 134.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_191968_1 2340.JV46_28360 0.0 991.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1J4DD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_191968_3 391008.Smal_2976 6.92e-20 85.9 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1X76E@135614|Xanthomonadales 135614|Xanthomonadales NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 k59_191968_4 1049564.TevJSym_ah00390 6.33e-93 278.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1J5PS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_191968_5 1049564.TevJSym_ah00400 1.81e-133 386.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1J4EI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_62688_1 218491.ECA3260 9.36e-22 89.4 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1MQK7@122277|Pectobacterium 1236|Gammaproteobacteria F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_62688_2 1279009.ADICEAN_01461 2.82e-08 53.1 COG3549@1|root,COG3549@2|Bacteria,4NSZ2@976|Bacteroidetes,47RJA@768503|Cytophagia 976|Bacteroidetes S PFAM Plasmid maintenance system killer - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_62688_4 1121007.AUML01000020_gene1078 1.24e-31 135.0 COG2931@1|root,COG3591@1|root,COG2931@2|Bacteria,COG3591@2|Bacteria,4NX38@976|Bacteroidetes,1IKNH@117743|Flavobacteriia,2YGKC@290174|Aquimarina 976|Bacteroidetes EQ Trypsin-like serine protease - - - - - - - - - - - - MAM,Trypsin_2 k59_55560_2 765911.Thivi_0731 3.3e-53 172.0 2BW2S@1|root,32QYV@2|Bacteria,1RI5M@1224|Proteobacteria,1S614@1236|Gammaproteobacteria,1WYK8@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_55560_3 1049564.TevJSym_aw00040 1.02e-44 149.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1J6JC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) hslR GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_55560_4 572477.Alvin_1023 1.23e-16 73.6 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1WZFE@135613|Chromatiales 135613|Chromatiales O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_44122_1 933262.AXAM01000044_gene1408 1.22e-193 552.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_95841_1 69328.PVLB_26492 9.71e-117 348.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_30079_1 313628.LNTAR_23894 3.53e-119 360.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - - k59_23874_2 1430440.MGMSRv2_3859 6.98e-116 337.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2U40G@28211|Alphaproteobacteria,2JT3A@204441|Rhodospirillales 204441|Rhodospirillales C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_23874_3 1049564.TevJSym_bo00020 1.82e-86 271.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1J4H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_140014_1 565045.NOR51B_1830 3.82e-38 137.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1J54C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_153183_3 83406.HDN1F_17340 6.54e-105 306.0 COG1569@1|root,COG1569@2|Bacteria,1RCZE@1224|Proteobacteria,1S52X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PIN domain - - - - - - - - - - - - PIN_3 k59_88459_2 177437.HRM2_02370 1.01e-40 152.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MIEI@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_62929_1 1265313.HRUBRA_02298 2.16e-33 124.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function Z012_09445 - - - - - - - - - - - Peptidase_M48 k59_62929_2 1244869.H261_01617 6.08e-07 52.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2JPJ7@204441|Rhodospirillales 204441|Rhodospirillales S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_153187_1 572477.Alvin_0381 2.08e-66 210.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1WWM1@135613|Chromatiales 135613|Chromatiales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_172518_1 1049564.TevJSym_au00560 5.92e-78 244.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1J50G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_55563_4 383407.XOC_2640 1.66e-13 68.2 COG3636@1|root,COG3636@2|Bacteria,1N75D@1224|Proteobacteria,1SC8G@1236|Gammaproteobacteria,1X8JJ@135614|Xanthomonadales 135614|Xanthomonadales K Addiction module - - - - - - - - - - - - - k59_55563_5 682795.AciX8_1034 1.58e-25 98.2 COG3657@1|root,COG3657@2|Bacteria,3Y8XE@57723|Acidobacteria,2JNTS@204432|Acidobacteriia 204432|Acidobacteriia S addiction module killer protein - - - - - - - - - - - - Gp49 k59_49619_2 1163407.UU7_08508 2.11e-102 301.0 COG0741@1|root,COG0741@2|Bacteria,1RAHP@1224|Proteobacteria,1S2AD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M lytic transglycosylase activity - - - - - - - - - - - - - k59_108082_2 880072.Desac_0837 1.53e-44 152.0 COG0685@1|root,COG0685@2|Bacteria,1RBND@1224|Proteobacteria,42QTG@68525|delta/epsilon subdivisions,2WN5D@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_204986_1 546274.EIKCOROL_02335 7.01e-08 58.2 COG4648@1|root,COG4648@2|Bacteria,1N0PK@1224|Proteobacteria,2VS0M@28216|Betaproteobacteria,2KR89@206351|Neisseriales 206351|Neisseriales S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - IspA k59_204986_2 765913.ThidrDRAFT_3306 3.08e-136 429.0 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1WW0H@135613|Chromatiales 135613|Chromatiales S MMPL family - - - - - - - - - - - - MMPL k59_192143_1 1306174.JODP01000002_gene5661 9.08e-07 58.9 2ENB9@1|root,33FYW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_44139_1 335543.Sfum_3291 5.83e-114 345.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_82176_1 1177154.Y5S_01708 1.55e-36 130.0 COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria 1236|Gammaproteobacteria U biopolymer transport protein - - - - - - - - - - - - ExbD k59_82176_2 1232410.KI421425_gene1543 4.53e-31 121.0 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_16663_1 1121403.AUCV01000050_gene2107 1.24e-124 363.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42M9R@68525|delta/epsilon subdivisions,2WKSR@28221|Deltaproteobacteria,2MHKR@213118|Desulfobacterales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_36912_1 96561.Dole_1366 1.75e-32 124.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria,2MJYX@213118|Desulfobacterales 28221|Deltaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_114315_1 207954.MED92_12636 2.79e-29 114.0 COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,1S7CW@1236|Gammaproteobacteria,1XKD0@135619|Oceanospirillales 135619|Oceanospirillales S Pfam Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_88470_1 56780.SYN_03249 2.05e-78 246.0 COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_3663_1 1232437.KL662033_gene2670 4.28e-22 98.6 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,2MHNX@213118|Desulfobacterales 28221|Deltaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_10929_1 289376.THEYE_A0546 2.73e-46 154.0 COG1793@1|root,COG1793@2|Bacteria 2|Bacteria L dna ligase ligD - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_101016_2 1274374.CBLK010000085_gene4629 8.4e-48 171.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,4HA89@91061|Bacilli,26U47@186822|Paenibacillaceae 91061|Bacilli F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_204992_1 1121405.dsmv_2907 3.56e-83 257.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,42Q7U@68525|delta/epsilon subdivisions,2WPC0@28221|Deltaproteobacteria,2MJIV@213118|Desulfobacterales 28221|Deltaproteobacteria H ThiF family moeB - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_186260_1 1121921.KB898706_gene3370 4.33e-22 97.8 COG2885@1|root,COG3210@1|root,COG2885@2|Bacteria,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,1RSAX@1236|Gammaproteobacteria,2PNKN@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria U haemagglutination activity domain cupB5 - - - - - - - - - - - ESPR,Glug,Haemagg_act k59_69332_1 349521.HCH_06117 1.17e-131 396.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales 135619|Oceanospirillales V (ABC) transporter - - - ko:K11004,ko:K13409 ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133 M00325,M00339,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2,3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_101023_1 1049564.TevJSym_ac02060 4.2e-36 135.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1J4NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_134065_1 1449357.JQLK01000001_gene1285 4.05e-05 48.5 COG2010@1|root,COG2010@2|Bacteria,1WJ3M@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C PFAM Cytochrome C - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_114325_1 686340.Metal_0711 5.28e-102 307.0 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria,1XE7B@135618|Methylococcales 135618|Methylococcales A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_114325_2 1240350.AMZE01000022_gene1255 3.85e-12 65.1 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1YUWW@136845|Pseudomonas putida group 1236|Gammaproteobacteria S tRNA-splicing ligase RtcB rtcB GO:0003674,GO:0003824,GO:0003909,GO:0005488,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0030145,GO:0033554,GO:0034641,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:0140098,GO:1901360 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_153202_1 400682.PAC_15705279 6.04e-74 239.0 COG2025@1|root,COG2086@1|root,KOG3180@2759|Eukaryota,KOG3954@2759|Eukaryota,38C7G@33154|Opisthokonta 33154|Opisthokonta C electron transfer flavoprotein subunit alpha - - - - - - - - - - - - ETF,ETF_alpha k59_140047_1 1123399.AQVE01000004_gene2609 2e-118 351.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria,461NX@72273|Thiotrichales 72273|Thiotrichales S Type VI secretion protein, EvpB/VC_A0108, tail sheath - - - - - - - - - - - - VipB k59_101025_1 439235.Dalk_0047 1.2e-61 204.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales 28221|Deltaproteobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_192160_1 323261.Noc_2851 0.000226 42.4 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_192160_2 1265505.ATUG01000002_gene1896 1.69e-62 206.0 COG2308@1|root,COG2308@2|Bacteria,1NG4H@1224|Proteobacteria,42WK0@68525|delta/epsilon subdivisions,2WS0X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_75160_1 751945.Theos_0605 1.48e-23 96.7 COG0517@1|root,COG0517@2|Bacteria,1WI6I@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM CBS domain - - - ko:K04767 - - - - ko00000 - - - CBS k59_121613_1 928724.SacglDRAFT_01793 1.39e-19 94.4 COG0697@1|root,COG0697@2|Bacteria,2GNSA@201174|Actinobacteria,4E396@85010|Pseudonocardiales 201174|Actinobacteria EG DMT(Drug metabolite transporter) superfamily permease - - - - - - - - - - - - EamA k59_30111_1 1121396.KB892914_gene109 1.38e-94 300.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MJ0S@213118|Desulfobacterales 28221|Deltaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_44157_2 870187.Thini_2444 1.33e-81 255.0 COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,1SC6D@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_16683_2 1217720.ALOX01000026_gene3498 9.26e-30 119.0 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,2JTIS@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_49639_1 1120998.AUFC01000045_gene929 8.24e-07 52.8 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia 186801|Clostridia KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_36925_1 1214065.BAGV01000014_gene3064 1.98e-118 357.0 COG2425@1|root,COG2425@2|Bacteria,1R55U@1224|Proteobacteria,1RSPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K11089 ko05322,map05322 - - - ko00000,ko00001 - - - TROVE,VWA_CoxE k59_95884_1 1129794.C427_0640 1.25e-33 128.0 COG3637@1|root,COG3637@2|Bacteria,1QXK4@1224|Proteobacteria,1T3DI@1236|Gammaproteobacteria,46752@72275|Alteromonadaceae 1236|Gammaproteobacteria M Bacterial SH3 domain - - - - - - - - - - - - OMP_b-brl,SH3_3,SH3_4 k59_114332_1 948106.AWZT01000022_gene3685 1.85e-97 304.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2VJ02@28216|Betaproteobacteria,1K2C2@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - 1.17.99.1 ko:K05797 ko00623,ko01100,ko01120,map00623,map01100,map01120 - R02675,R11194 RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_186456_1 933262.AXAM01000008_gene1934 3.32e-84 258.0 COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales 28221|Deltaproteobacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_153369_1 1049564.TevJSym_ak00810 1.65e-159 462.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1J4HB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_121846_1 283699.D172_3448 1.08e-05 54.7 COG1462@1|root,COG1462@2|Bacteria,1QR7B@1224|Proteobacteria,1S1DD@1236|Gammaproteobacteria,2Q1M1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - CsgG,PG_binding_1 k59_69585_1 1165841.SULAR_00500 9.83e-57 196.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,42PHJ@68525|delta/epsilon subdivisions,2YNKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_37126_1 177437.HRM2_02370 2.83e-91 296.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MIEI@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_155276_1 335543.Sfum_1179 1.75e-117 352.0 COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales 28221|Deltaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 k59_25873_1 1049564.TevJSym_as00640 8.98e-83 271.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1J4D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_116363_1 314345.SPV1_06084 1.32e-78 241.0 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria 1224|Proteobacteria S PFAM conserved - - - - - - - - - - - - DUF2461 k59_116363_2 768671.ThimaDRAFT_3049 2.43e-206 591.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_148907_1 933262.AXAM01000034_gene1559 4.75e-60 200.0 COG0664@1|root,COG0664@2|Bacteria,1R8R8@1224|Proteobacteria,42PH6@68525|delta/epsilon subdivisions,2WKQJ@28221|Deltaproteobacteria,2MJ5X@213118|Desulfobacterales 28221|Deltaproteobacteria T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_148907_2 1122201.AUAZ01000043_gene1279 1.88e-41 152.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,46A76@72275|Alteromonadaceae 1236|Gammaproteobacteria P Sodium:sulfate symporter transmembrane region yfbS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_77252_2 1049564.TevJSym_as00340 6.3e-117 342.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_194215_1 1121015.N789_03655 1.72e-55 196.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1XCCP@135614|Xanthomonadales 135614|Xanthomonadales M COG3209 Rhs family protein - - - - - - - - - - - - - k59_194215_3 1121015.N789_03650 1.82e-39 134.0 2EGCA@1|root,33A43@2|Bacteria,1P3A1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_32221_1 118168.MC7420_6251 1.85e-36 142.0 COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria,1H8MG@1150|Oscillatoriales 1117|Cyanobacteria T GGDEF domain' - - - - - - - - - - - - CBS,CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_90610_1 335543.Sfum_0259 2.58e-115 353.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MR9G@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_194216_1 765911.Thivi_0099 1.3e-61 199.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_194216_2 765910.MARPU_15095 1.49e-09 55.1 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1WY82@135613|Chromatiales 135613|Chromatiales H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_148916_1 1242864.D187_006829 3.46e-51 185.0 COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria,43C6Z@68525|delta/epsilon subdivisions 1224|Proteobacteria IQ nonribosomal peptide - - - ko:K18660 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C,Condensation,Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_142327_1 861299.J421_5640 1.8e-44 160.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 2|Bacteria I Myo-inositol-1-phosphate synthase ino1_1 - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 k59_84168_1 335543.Sfum_0376 3.42e-56 182.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,2MQIP@213462|Syntrophobacterales 28221|Deltaproteobacteria M Bacterial lipid A biosynthesis acyltransferase htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_84168_2 1121405.dsmv_0518 1.18e-28 115.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM lipopolysaccharide heptosyltransferase II - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_174382_1 765913.ThidrDRAFT_0560 1.53e-84 266.0 COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1X07F@135613|Chromatiales 135613|Chromatiales C TIGRFAM Formylmethanofuran dehydrogenase, subunit A - - 1.2.7.12 ko:K00200 ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 k59_84170_2 1121405.dsmv_0655 7.49e-77 236.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,42MX4@68525|delta/epsilon subdivisions,2WKVB@28221|Deltaproteobacteria,2MHKN@213118|Desulfobacterales 28221|Deltaproteobacteria S ATPase associated with various cellular activities AAA_5 - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_25877_1 768671.ThimaDRAFT_4400 3.75e-216 607.0 COG3659@1|root,COG3659@2|Bacteria,1QMC3@1224|Proteobacteria,1S8GE@1236|Gammaproteobacteria,1WYNB@135613|Chromatiales 135613|Chromatiales M PFAM Carbohydrate-selective porin OprB - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_200154_1 555779.Dthio_PD3705 3.8e-94 284.0 2DB88@1|root,2Z7QT@2|Bacteria,1R0WJ@1224|Proteobacteria,42RMG@68525|delta/epsilon subdivisions,2WNWJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_200154_2 1540257.JQMW01000009_gene2977 1.03e-05 52.4 COG3599@1|root,COG3599@2|Bacteria,1TRNH@1239|Firmicutes,25EYI@186801|Clostridia,36K7J@31979|Clostridiaceae 186801|Clostridia D Transposase - - - - - - - - - - - - DDE_Tnp_IS66,zf-IS66 k59_18894_1 387631.Asulf_00353 7.09e-52 178.0 arCOG03874@1|root,arCOG03874@2157|Archaea,2Y7GA@28890|Euryarchaeota 28890|Euryarchaeota S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 k59_142344_1 573413.Spirs_4181 1.42e-122 356.0 COG0656@1|root,COG0656@2|Bacteria,2J5XV@203691|Spirochaetes 203691|Spirochaetes S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_84179_1 118161.KB235919_gene6402 1.06e-53 184.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_116401_1 232721.Ajs_4275 4.55e-10 56.6 COG1476@1|root,COG1476@2|Bacteria,1REV7@1224|Proteobacteria,2VRF1@28216|Betaproteobacteria 28216|Betaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_116401_2 717772.THIAE_04835 2.6e-10 56.6 COG3905@1|root,COG3905@2|Bacteria,1MZPQ@1224|Proteobacteria,1S8Y6@1236|Gammaproteobacteria 1236|Gammaproteobacteria K copG family - - - - - - - - - - - - RHH_1 k59_51849_1 28072.Nos7524_3258 5.32e-10 67.4 COG1572@1|root,COG1864@1|root,COG3209@1|root,COG3210@1|root,COG3291@1|root,COG3386@1|root,COG3391@1|root,COG1572@2|Bacteria,COG1864@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,1GQ08@1117|Cyanobacteria,1HRMZ@1161|Nostocales 1117|Cyanobacteria U PKD domain - - - - - - - - - - - - CARDB,Calx-beta,PKD,RHS_repeat k59_148936_1 1049564.TevJSym_bp00140 4.46e-29 113.0 COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1J630@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG3103 SH3 domain protein ygiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - ko:K07184 - - - - ko00000 - - - SH3_3 k59_148936_2 1479237.JMLY01000001_gene1496 7.95e-64 204.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,465TZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3,2.1.3.6,2.1.3.9 ko:K00611,ko:K09065,ko:K13252 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01398,R07245 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_25886_1 105559.Nwat_2213 2.03e-63 212.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1WWGJ@135613|Chromatiales 135613|Chromatiales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_174405_1 1049564.TevJSym_ac00420 3.65e-109 322.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1J5ER@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Polysaccharide biosynthesis protein capI - 5.1.3.25,5.1.3.6 ko:K08679,ko:K17947 ko00520,ko00523,ko01100,ko01130,map00520,map00523,map01100,map01130 - R01385,R10279 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_194237_1 439235.Dalk_3262 5.93e-61 190.0 COG0745@1|root,COG0745@2|Bacteria,1RINR@1224|Proteobacteria,42T1R@68525|delta/epsilon subdivisions,2WPHY@28221|Deltaproteobacteria,2MK8T@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_18906_1 396588.Tgr7_1950 6.11e-78 246.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0027 rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_142359_1 96561.Dole_0026 6.49e-68 218.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MIT8@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_142359_2 335543.Sfum_3972 1.06e-41 151.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,42ZIG@68525|delta/epsilon subdivisions,2WUZE@28221|Deltaproteobacteria 28221|Deltaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_77281_1 78398.KS43_09220 1.98e-32 124.0 arCOG14100@1|root,2Z924@2|Bacteria,1R4ME@1224|Proteobacteria,1T6CC@1236|Gammaproteobacteria,1MTDD@122277|Pectobacterium 1236|Gammaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_77281_2 561231.Pecwa_0451 7.44e-103 318.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RRBD@1236|Gammaproteobacteria,1MT2M@122277|Pectobacterium 1236|Gammaproteobacteria S Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_181321_1 243231.GSU2241 3.57e-123 362.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,43TPG@69541|Desulfuromonadales 28221|Deltaproteobacteria M NAD(P)H-binding uge - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_200165_1 933262.AXAM01000100_gene3390 2.78e-45 157.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,2MHS9@213118|Desulfobacterales 28221|Deltaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_200165_2 1121405.dsmv_3102 1.5e-11 63.9 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MHSK@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_148939_2 1380358.JADJ01000023_gene3895 5.49e-101 307.0 COG4974@1|root,COG4974@2|Bacteria,1RBMG@1224|Proteobacteria,1T3CP@1236|Gammaproteobacteria,1XRTU@135619|Oceanospirillales 135619|Oceanospirillales L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_116414_1 1163407.UU7_02567 4.57e-46 161.0 2EAUI@1|root,334W6@2|Bacteria 2|Bacteria S Novel toxin 15 - - - - - - - - - - - - Ntox15 k59_116414_2 686340.Metal_2427 6.82e-45 158.0 2EJ9B@1|root,33D0H@2|Bacteria,1NM2G@1224|Proteobacteria,1SRJJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_103602_1 179408.Osc7112_5898 2.76e-26 120.0 COG3464@1|root,COG3464@2|Bacteria,1G377@1117|Cyanobacteria,1HB17@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Transposase, IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_6109_1 948565.AFFP02000003_gene2064 2.26e-87 270.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1Y7R8@135625|Pasteurellales 135625|Pasteurellales P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 k59_6109_2 713586.KB900536_gene2679 1.25e-41 145.0 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1318) - - - - - - - - - - - - DUF1318 k59_207205_1 1049564.TevJSym_bh00080 6.96e-75 249.0 28JIE@1|root,2Z9BR@2|Bacteria,1R952@1224|Proteobacteria,1RRHU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD k59_207205_2 1049564.TevJSym_bh00090 7.16e-29 126.0 COG0457@1|root,COG0457@2|Bacteria,1PYTB@1224|Proteobacteria,1RSFQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Tetratricopeptide - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_16 k59_19397_4 1132836.RCCGE510_02626 6.36e-09 57.8 COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,2U71S@28211|Alphaproteobacteria,4BCTW@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_19397_6 717774.Marme_3931 1.7e-28 119.0 COG2207@1|root,COG2207@2|Bacteria,1R71R@1224|Proteobacteria,1RPUM@1236|Gammaproteobacteria,1XJZ8@135619|Oceanospirillales 135619|Oceanospirillales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_19397_8 5465.ENH79550 0.000795 44.3 KOG3178@1|root,KOG3178@2759|Eukaryota,39REH@33154|Opisthokonta,3P0F5@4751|Fungi,3QNI1@4890|Ascomycota,2124N@147550|Sordariomycetes,1EWKV@1028384|Glomerellales 4751|Fungi Q O-methyltransferase - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_57985_1 335543.Sfum_2566 1.29e-106 327.0 COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit - - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_207217_1 530564.Psta_3555 1.52e-60 195.0 COG1191@1|root,COG1191@2|Bacteria,2IX9S@203682|Planctomycetes 203682|Planctomycetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_77713_1 96561.Dole_3029 4.4e-70 233.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_57986_1 1320556.AVBP01000022_gene2094 7.7e-38 145.0 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,2U4TG@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ketoacyl-synt k59_207221_1 391626.OAN307_c48680 5.91e-79 243.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TS16@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG1484 DNA replication protein - - - - - - - - - - - - IstB_IS21 k59_103629_2 1049564.TevJSym_ah00560 2.35e-89 266.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1J7B7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosyl transferase domain hpt GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_200710_2 1049564.TevJSym_aw00330 1.36e-210 591.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N k59_6152_1 640511.BC1002_4161 2.51e-07 53.5 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VHHF@28216|Betaproteobacteria,1K2JB@119060|Burkholderiaceae 28216|Betaproteobacteria M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_58021_1 1283284.AZUK01000001_gene211 7.57e-43 144.0 2DNU1@1|root,32Z4S@2|Bacteria,1N8FB@1224|Proteobacteria,1SDR3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_111680_1 1232437.KL661988_gene177 7.29e-32 120.0 2DU0J@1|root,32UW9@2|Bacteria,1MZ9C@1224|Proteobacteria,42U2K@68525|delta/epsilon subdivisions,2WQ3B@28221|Deltaproteobacteria,2MKHZ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_156975_1 1049564.TevJSym_aj00810 1.08e-191 557.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1J907@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain ttrA - 1.8.5.5,1.8.5.6 ko:K08352,ko:K08357,ko:K21307 ko00920,ko01100,ko01120,ko02020,map00920,map01100,map01120,map02020 - R10149,R10150,R11487 RC00168,RC02823,RC03109 ko00000,ko00001,ko01000,ko02000 5.A.3.10,5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_33878_1 1049564.TevJSym_ab00650 3.84e-83 268.0 COG2304@1|root,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1RZHF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S serine threonine protein kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - VWA,VWA_2 k59_7917_1 1163617.SCD_n02434 6.4e-167 523.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria 28216|Betaproteobacteria G 4-alpha-glucanotransferase treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_7917_2 1121935.AQXX01000142_gene2347 8.94e-46 156.0 COG0123@1|root,COG0123@2|Bacteria 2|Bacteria BQ including yeast histone deacetylase and acetoin utilization protein - - 3.5.1.98 ko:K11418 ko05034,ko05165,ko05203,map05034,map05165,map05203 - - - ko00000,ko00001,ko01000,ko03036 - - - Hist_deacetyl k59_7917_3 1238450.VIBNISOn1_970105 7.37e-31 118.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RPVZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_183084_2 335543.Sfum_1167 5.19e-08 53.9 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,2MR0N@213462|Syntrophobacterales 28221|Deltaproteobacteria C ferredoxin oxidoreductase beta subunit - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1219_1 1333856.L686_09820 2.84e-25 107.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1Z24R@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_66147_1 335543.Sfum_2578 1.41e-151 442.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MQ65@213462|Syntrophobacterales 28221|Deltaproteobacteria A Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_79526_1 706587.Desti_0878 2.36e-09 57.4 COG1962@1|root,COG1962@2|Bacteria,1R7QQ@1224|Proteobacteria 1224|Proteobacteria H TIGRFAM N5-methyltetrahydromethanopterin coenzyme M methyltransferase subunit H - - 2.1.1.86 ko:K00584 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00357,M00567 R04347 RC00035,RC00113,RC02892 ko00000,ko00001,ko00002,ko01000 - - - MtrH k59_79526_2 1265505.ATUG01000002_gene1098 8.92e-46 160.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,2MP6C@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0016 URO-D k59_98456_1 1304885.AUEY01000002_gene347 1.06e-46 165.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_40446_1 871968.DESME_06975 1.62e-61 215.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,260UC@186807|Peptococcaceae 186801|Clostridia KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - CBS,HTH_8,PAS,PAS_9,Sigma54_activat k59_202478_1 396588.Tgr7_2181 3.17e-53 169.0 COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria,1WYQ6@135613|Chromatiales 135613|Chromatiales P Part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_46772_1 1121396.KB893105_gene1803 5.12e-90 272.0 COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MI2C@213118|Desulfobacterales 28221|Deltaproteobacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Radical_SAM k59_189544_1 1318628.MARLIPOL_16284 2.8e-41 145.0 2CDFF@1|root,32RXP@2|Bacteria,1N26W@1224|Proteobacteria,1SUQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_59819_1 106370.Francci3_2919 1.66e-08 58.9 COG3853@1|root,COG3853@2|Bacteria,2GNWN@201174|Actinobacteria 201174|Actinobacteria P Toxic anion resistance - - - - - - - - - - - - TelA k59_59819_2 349521.HCH_05410 4.42e-101 303.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,1XIZT@135619|Oceanospirillales 135619|Oceanospirillales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_79529_1 765912.Thimo_0181 6.63e-65 201.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1WY3G@135613|Chromatiales 135613|Chromatiales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_72666_1 765912.Thimo_2191 3.91e-12 65.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_72666_2 1205753.A989_03180 0.000197 42.4 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,1X7XK@135614|Xanthomonadales 135614|Xanthomonadales NU Belongs to the N-Me-Phe pilin family - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_85672_1 335543.Sfum_2687 1.01e-111 337.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales 28221|Deltaproteobacteria F PFAM Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_92256_1 335543.Sfum_1544 6.2e-93 275.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria,2MQF6@213462|Syntrophobacterales 28221|Deltaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_14171_1 1380387.JADM01000016_gene3784 8.3e-90 278.0 COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,1RZ1H@1236|Gammaproteobacteria,1XMQ5@135619|Oceanospirillales 135619|Oceanospirillales P Toxic anion resistance - - - - - - - - - - - - TelA k59_118288_1 1122176.KB903553_gene3616 1.19e-129 380.0 COG0688@1|root,COG0688@2|Bacteria,4NR69@976|Bacteroidetes 976|Bacteroidetes I Belongs to the phosphatidylserine decarboxylase family - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PSDC,PS_Dcarbxylase k59_118288_2 1129374.AJE_07256 3.88e-28 103.0 COG3668@1|root,COG3668@2|Bacteria,1RKAK@1224|Proteobacteria,1SD8T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_131276_1 765911.Thivi_3738 3.12e-117 363.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_189550_1 187303.BN69_1081 6.22e-116 377.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,36YC7@31993|Methylocystaceae 28211|Alphaproteobacteria S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_144258_1 765912.Thimo_3319 8.26e-85 272.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_7939_1 1121396.KB892913_gene117 3.82e-53 177.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2X5JU@28221|Deltaproteobacteria,2MPFA@213118|Desulfobacterales 28221|Deltaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_7939_2 136993.KB900627_gene545 1.69e-14 73.6 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1237_1 909663.KI867150_gene2391 5.23e-46 154.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MRIT@213462|Syntrophobacterales 28221|Deltaproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1237_2 1265505.ATUG01000003_gene453 3.76e-10 62.4 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria,2MJ5H@213118|Desulfobacterales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07644 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_79542_1 660470.Theba_0189 5.39e-24 108.0 COG5421@1|root,COG5421@2|Bacteria,2GE18@200918|Thermotogae 200918|Thermotogae L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_156999_2 1049564.TevJSym_ab00030 1.65e-27 110.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_1239_1 398580.Dshi_2295 2.42e-48 169.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_202491_1 56780.SYN_02215 1.45e-23 102.0 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_9 k59_53226_1 9818.XP_007935076.1 8.75e-14 72.4 COG0350@1|root,KOG4062@2759|Eukaryota,3A29E@33154|Opisthokonta,3BPUX@33208|Metazoa,3D0M7@33213|Bilateria,47Z3U@7711|Chordata,498MH@7742|Vertebrata,3JAU2@40674|Mammalia,356XW@311790|Afrotheria 33208|Metazoa L methylated-DNA--protein-cysteine methyltransferase MGMT GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003908,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006282,GO:0006304,GO:0006305,GO:0006306,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0007275,GO:0007584,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009008,GO:0009314,GO:0009605,GO:0009628,GO:0009636,GO:0009888,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010212,GO:0010243,GO:0010604,GO:0010941,GO:0014070,GO:0016740,GO:0016741,GO:0016765,GO:0019219,GO:0019222,GO:0030154,GO:0030162,GO:0030855,GO:0030879,GO:0031323,GO:0031325,GO:0031667,GO:0031974,GO:0031981,GO:0032259,GO:0032501,GO:0032502,GO:0033273,GO:0033554,GO:0034599,GO:0034641,GO:0035510,GO:0042221,GO:0042493,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043281,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044728,GO:0045471,GO:0045739,GO:0045935,GO:0046483,GO:0046677,GO:0046872,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0051246,GO:0051336,GO:0051593,GO:0051716,GO:0052547,GO:0052548,GO:0060255,GO:0060429,GO:0060548,GO:0060644,GO:0061180,GO:0065007,GO:0065009,GO:0070013,GO:0070887,GO:0071214,GO:0071310,GO:0071407,GO:0071478,GO:0071479,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097305,GO:0104004,GO:0140097,GO:1901360,GO:1901363,GO:1901698,GO:1901700,GO:2000116,GO:2000779,GO:2000781,GO:2001020,GO:2001022 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_53226_2 1515746.HR45_01840 1.55e-10 63.2 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,2QA4Z@267890|Shewanellaceae 1236|Gammaproteobacteria D Tyrosine recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_79543_1 1049564.TevJSym_ar00170 1.32e-14 70.5 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1J573@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_79543_2 1207076.ALAT01000147_gene407 6.8e-97 295.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1Z0UF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_40450_1 1249627.D779_2807 4.49e-106 331.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1WVVP@135613|Chromatiales 135613|Chromatiales K PFAM Tex-like protein N-terminal - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_40450_6 714943.Mucpa_6137 7.64e-14 73.9 28HPC@1|root,2Z7XD@2|Bacteria,4NYNG@976|Bacteroidetes,1IYND@117747|Sphingobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4337) - - - - - - - - - - - - DUF4337 k59_40450_7 573061.Clocel_1100 8.78e-49 174.0 COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,36E5I@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_144262_2 69042.WH5701_13770 3.12e-25 106.0 COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria,1GZ3E@1129|Synechococcus 1117|Cyanobacteria G 6-phosphogluconolactonase pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_144262_3 1049564.TevJSym_ad00930 1.91e-27 110.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1J4GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_72680_1 1123504.JQKD01000003_gene597 8.11e-25 109.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,4ABJ6@80864|Comamonadaceae 28216|Betaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin PilY1-like protein - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_131289_1 153721.MYP_2469 7.97e-30 122.0 COG5659@1|root,COG5659@2|Bacteria,4NQCF@976|Bacteroidetes,47UV4@768503|Cytophagia 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_20927_1 1049564.TevJSym_ac01970 2.7e-186 539.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J4XS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_195618_1 391625.PPSIR1_23199 3.02e-13 68.9 COG5018@1|root,COG5018@2|Bacteria,1RE77@1224|Proteobacteria,43DRQ@68525|delta/epsilon subdivisions,2WYQI@28221|Deltaproteobacteria,2Z0DA@29|Myxococcales 28221|Deltaproteobacteria L EXOIII - - - - - - - - - - - - RNase_T k59_27417_2 1049564.TevJSym_ah00930 1.25e-100 299.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1J7ZS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA soxA - 1.8.2.2 ko:K17222,ko:K19713 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - - k59_124734_1 1049564.TevJSym_av00420 2.32e-32 126.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1J66T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Bacterial sugar transferase rfbP GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0016740,GO:0016772,GO:0016780,GO:0043170,GO:0044238,GO:0071704 2.7.8.6 ko:K00996,ko:K16707 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 k59_124734_2 1049564.TevJSym_av00430 5.92e-262 726.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1J4CI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM k59_124734_3 1049564.TevJSym_av00440 1.92e-19 80.9 2E5B5@1|root,33039@2|Bacteria,1NDK8@1224|Proteobacteria,1SFKE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_150702_1 1236689.MMALV_00360 2.71e-51 166.0 COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,3F2PJ@33867|unclassified Euryarchaeota 28890|Euryarchaeota F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_53231_1 1442599.JAAN01000021_gene2358 1.2e-49 160.0 2BWGA@1|root,2ZC12@2|Bacteria,1RD78@1224|Proteobacteria,1S6F4@1236|Gammaproteobacteria,1XA4A@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_53231_2 1123368.AUIS01000006_gene515 2.37e-31 110.0 2E5DP@1|root,32SKX@2|Bacteria,1N1MD@1224|Proteobacteria,1SG74@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_53231_3 1122201.AUAZ01000004_gene3436 3.12e-55 179.0 COG0817@1|root,COG0817@2|Bacteria,1RCYK@1224|Proteobacteria,1S3HF@1236|Gammaproteobacteria 1236|Gammaproteobacteria L genomic island protein Bartonella henselae str. Houston-1 gi 49238285 emb CAF27499.1 and to - - - - - - - - - - - - - k59_20932_1 1485545.JQLW01000006_gene421 3.23e-05 47.8 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria 1224|Proteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_20932_2 1304885.AUEY01000010_gene1676 2.05e-24 99.4 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,42R3K@68525|delta/epsilon subdivisions,2WJNA@28221|Deltaproteobacteria,2MJFV@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_144263_1 765913.ThidrDRAFT_2281 3.27e-89 265.0 COG3516@1|root,COG3516@2|Bacteria,1RAZQ@1224|Proteobacteria,1RY42@1236|Gammaproteobacteria,1WYEI@135613|Chromatiales 135613|Chromatiales S Type VI secretion protein, VC_A0107 family - - - ko:K11901 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VipA k59_144263_2 765913.ThidrDRAFT_2280 1.03e-89 280.0 COG3515@1|root,COG3515@2|Bacteria,1NK35@1224|Proteobacteria,1RQHZ@1236|Gammaproteobacteria,1WYRE@135613|Chromatiales 135613|Chromatiales S ImpA, N-terminal, type VI secretion system - - - ko:K11902 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - ImpA_N k59_144263_3 287.DR97_3052 7e-24 102.0 COG3210@1|root,COG3501@1|root,COG3210@2|Bacteria,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,1YIPB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Gp5 C-terminal repeat (3 copies) - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Gp5_C,Phage_GPD k59_85694_1 472759.Nhal_3523 6.83e-33 119.0 2DHBG@1|root,2ZZ37@2|Bacteria,1RGFW@1224|Proteobacteria,1S5S9@1236|Gammaproteobacteria,1WZU3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_85694_2 472759.Nhal_3522 1.75e-61 194.0 COG4226@1|root,COG4226@2|Bacteria 2|Bacteria K protein encoded in hypervariable junctions of pilus gene clusters - - - - - - - - - - - - HicB k59_40459_1 1121406.JAEX01000007_gene2442 3.04e-25 106.0 COG2890@1|root,COG2890@2|Bacteria,1N5B4@1224|Proteobacteria,42VIS@68525|delta/epsilon subdivisions,2WR53@28221|Deltaproteobacteria,2M92A@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM methyltransferase small - - - - - - - - - - - - Methyltransf_16 k59_14192_1 765912.Thimo_3271 4.49e-18 86.7 COG0374@1|root,COG0374@2|Bacteria,1R6ND@1224|Proteobacteria,1RZ8Y@1236|Gammaproteobacteria,1WXJJ@135613|Chromatiales 135613|Chromatiales C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases k59_79557_1 1049564.TevJSym_aq00040 1.7e-73 233.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1J4NI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_92291_1 395493.BegalDRAFT_3086 6.79e-84 277.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,45ZTB@72273|Thiotrichales 72273|Thiotrichales C Domain of unknown function (DUF3400) - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_144268_1 105559.Nwat_0930 3.2e-51 169.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1WXKN@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_98483_1 909663.KI867150_gene2032 3.07e-37 144.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1PFBE@1224|Proteobacteria,42YSB@68525|delta/epsilon subdivisions,2WU00@28221|Deltaproteobacteria,2MR36@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HisKA k59_202507_1 1459636.NTE_01195 7.09e-10 57.8 COG1522@1|root,arCOG01117@2157|Archaea 1459636.NTE_01195|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_94067_3 1049564.TevJSym_ap00150 2.85e-124 374.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1J55U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase pcoA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_94067_4 1049564.TevJSym_ap00140 8.15e-132 377.0 COG3667@1|root,COG3667@2|Bacteria,1MXW6@1224|Proteobacteria,1RZEY@1236|Gammaproteobacteria,1J66N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Copper resistance protein B precursor (CopB) copB - - ko:K07233 - - - - ko00000 - - - CopB k59_94067_5 935261.JAGL01000003_gene3122 1.56e-39 156.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,43IGX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_61273_1 1248916.ANFY01000006_gene1981 2.12e-10 63.9 COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VFY5@28211|Alphaproteobacteria,2K1MD@204457|Sphingomonadales 204457|Sphingomonadales E Putative serine dehydratase domain - - 4.3.1.27 ko:K20757 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat k59_126499_1 572477.Alvin_0861 1.1e-37 134.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_190957_2 1121456.ATVA01000013_gene908 2.41e-15 76.3 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2M7QK@213115|Desulfovibrionales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_42253_2 1125863.JAFN01000001_gene167 8.22e-26 102.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42N2W@68525|delta/epsilon subdivisions,2WJRB@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter - - - - - - - - - - - - ABC_tran k59_73829_1 1128421.JAGA01000003_gene3571 1.2e-41 147.0 COG0755@1|root,COG0755@2|Bacteria,2NPGT@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmC GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm k59_196887_1 388051.AUFE01000166_gene71 5.24e-109 334.0 COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,2VMNS@28216|Betaproteobacteria,1KE34@119060|Burkholderiaceae 28216|Betaproteobacteria S Involved in initiation control of chromosome replication - - - - - - - - - - - - DDE_Tnp_IS66 k59_106490_1 335543.Sfum_1469 1.7e-113 334.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,2MRHZ@213462|Syntrophobacterales 28221|Deltaproteobacteria G Fructose-bisphosphate aldolase class-II fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_15331_1 1049564.TevJSym_an00690 4.58e-59 198.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1J531@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M M COG4775 Outer membrane protein protective antigen OMA87 tamA - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_15331_2 1049564.TevJSym_an00700 0.0 968.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1J546@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ytfN GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_113044_1 697282.Mettu_3020 1.84e-197 606.0 COG5635@1|root,COG5635@2|Bacteria,1N2JA@1224|Proteobacteria,1SN4A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Nacht domain - - - - - - - - - - - - - k59_42255_1 56780.SYN_01262 3.86e-134 388.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MQW9@213462|Syntrophobacterales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_145607_1 497321.C664_15303 4.27e-71 223.0 COG1010@1|root,COG1010@2|Bacteria,1MU79@1224|Proteobacteria,2VIG5@28216|Betaproteobacteria,2KUEX@206389|Rhodocyclales 206389|Rhodocyclales H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_145607_2 159087.Daro_1686 2.38e-58 184.0 COG2073@1|root,COG2073@2|Bacteria,1RHAC@1224|Proteobacteria,2VSRI@28216|Betaproteobacteria,2KWNX@206389|Rhodocyclales 206389|Rhodocyclales H Cobalamin synthesis G C-terminus cbiGb - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C k59_145607_3 1304883.KI912532_gene990 6.5e-100 295.0 COG2073@1|root,COG2073@2|Bacteria,1MWE6@1224|Proteobacteria,2VP0M@28216|Betaproteobacteria,2KUBU@206389|Rhodocyclales 206389|Rhodocyclales H Cobalamin synthesis G N-terminal cbiGa - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_N,CbiG_mid k59_87090_1 335543.Sfum_1225 2.34e-162 493.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_80859_1 717773.Thicy_0774 3.7e-165 477.0 COG4626@1|root,COG4626@2|Bacteria,1MW9D@1224|Proteobacteria,1RRNP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase - - - - - - - - - - - - - k59_80859_2 1537994.JQFW01000015_gene1603 2.81e-29 109.0 2E32Z@1|root,32Y37@2|Bacteria,1N9DU@1224|Proteobacteria,1SCBF@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_48224_1 465817.ETA_11060 1.78e-18 90.1 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,1RNZB@1236|Gammaproteobacteria,3X4CT@551|Erwinia 1236|Gammaproteobacteria K LysR family transcriptional regulator yfeR GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1990837 - ko:K17737 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_48224_2 1117647.M5M_00445 3.86e-87 280.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,1J58B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_9433_3 754477.Q7C_2327 4.18e-54 173.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,1S653@1236|Gammaproteobacteria,460W1@72273|Thiotrichales 72273|Thiotrichales N Belongs to the flagella basal body rod proteins family - - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_67759_1 1249627.D779_2820 1.36e-157 454.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1X2EF@135613|Chromatiales 135613|Chromatiales E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_94081_1 933262.AXAM01000020_gene34 1.71e-127 368.0 arCOG10401@1|root,2ZA7Y@2|Bacteria,1R45R@1224|Proteobacteria,42MDG@68525|delta/epsilon subdivisions,2WKTC@28221|Deltaproteobacteria,2MIT0@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_15335_1 1049564.TevJSym_ad01650 3.97e-28 106.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1J634@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO COG0526 Thiol-disulfide isomerase and thioredoxins ccmG - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_15335_2 1049564.TevJSym_ad01660 1.34e-59 201.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_42265_1 880072.Desac_1405 9.71e-54 179.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2WK8E@28221|Deltaproteobacteria,2MQDP@213462|Syntrophobacterales 28221|Deltaproteobacteria H PFAM UbiA prenyltransferase ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_190965_2 555778.Hneap_0029 7.48e-24 103.0 COG0524@1|root,COG2146@1|root,COG0524@2|Bacteria,COG2146@2|Bacteria,1MWX4@1224|Proteobacteria,1RQW6@1236|Gammaproteobacteria,1WWFX@135613|Chromatiales 135613|Chromatiales G PFAM PfkB domain protein - - 2.7.1.3 ko:K00846 ko00051,ko01100,ko01120,map00051,map01100,map01120 - R00866,R03819 RC00002,RC00017,RC00608 ko00000,ko00001,ko01000,ko04147 - - - PfkB k59_145610_1 1504672.669785679 4.12e-72 231.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,4AF3N@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase, mutator type - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_80863_1 1121406.JAEX01000009_gene2633 1.7e-14 67.4 COG1522@1|root,COG1522@2|Bacteria,1QX2E@1224|Proteobacteria,43BVU@68525|delta/epsilon subdivisions,2X76I@28221|Deltaproteobacteria,2MHA0@213115|Desulfovibrionales 28221|Deltaproteobacteria K sequence-specific DNA binding - - - - - - - - - - - - - k59_54486_1 1042377.AFPJ01000036_gene1233 1.54e-78 253.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_184712_1 702450.CUW_1434 2.02e-59 207.0 COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,3VTNX@526524|Erysipelotrichia 526524|Erysipelotrichia S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_99748_1 1121405.dsmv_0376 7.19e-75 237.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42Q99@68525|delta/epsilon subdivisions,2WJUI@28221|Deltaproteobacteria,2MKWA@213118|Desulfobacterales 28221|Deltaproteobacteria E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_190966_2 314345.SPV1_12290 1.71e-73 231.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria 1224|Proteobacteria BQ Including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_67761_2 105559.Nwat_1216 8.29e-41 136.0 COG2119@1|root,COG2119@2|Bacteria,1N85A@1224|Proteobacteria,1SAAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_138891_1 1121405.dsmv_2245 2.12e-47 171.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2MHZB@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_87335_1 1333856.L686_09305 2.6e-64 224.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1Z1JU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_145820_1 1122622.ATWJ01000007_gene1879 5.4e-23 103.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2GMEE@201174|Actinobacteria,4FFTD@85021|Intrasporangiaceae 201174|Actinobacteria E COG0411 ABC-type branched-chain amino acid transport systems ATPase component - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_9688_1 177437.HRM2_37370 1.36e-11 61.6 COG1406@1|root,COG1406@2|Bacteria,1RATZ@1224|Proteobacteria,42R2Q@68525|delta/epsilon subdivisions,2WP6F@28221|Deltaproteobacteria,2MJQ2@213118|Desulfobacterales 28221|Deltaproteobacteria N Chemotaxis phosphatase CheX - - - ko:K03409 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheX k59_9688_2 795359.TOPB45_1325 7.12e-54 172.0 COG0745@1|root,COG0745@2|Bacteria,2GHUW@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T Response regulator receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_9688_3 439235.Dalk_0899 4.19e-37 129.0 COG2204@1|root,COG2204@2|Bacteria,1QW8K@1224|Proteobacteria,42V8F@68525|delta/epsilon subdivisions,2WRMW@28221|Deltaproteobacteria,2MNUV@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_99951_1 883078.HMPREF9695_00202 1.55e-10 64.7 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3JWJH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter MA20_29500 - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_99951_2 1320556.AVBP01000010_gene3291 2.33e-26 110.0 COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,43HPP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family MA20_29495 - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_191185_1 1123400.KB904765_gene1381 2.45e-26 106.0 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyl Transferase - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 k59_191185_2 883126.HMPREF9710_01341 2.28e-140 411.0 COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,2VNQ8@28216|Betaproteobacteria,473SU@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyl transferase 4-like wbpZ - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_191185_3 1027273.GZ77_02315 2.68e-140 410.0 COG0438@1|root,COG0438@2|Bacteria,1P81Z@1224|Proteobacteria,1S2B8@1236|Gammaproteobacteria,1XN79@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_48478_1 335543.Sfum_0122 1.73e-108 341.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MQ7V@213462|Syntrophobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_54695_1 384765.SIAM614_05823 8.96e-11 65.9 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_94424_1 1047013.AQSP01000106_gene1765 4.73e-73 233.0 COG1509@1|root,COG1509@2|Bacteria,2NNY6@2323|unclassified Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2,5.4.3.9 ko:K01843,ko:K19810,ko:K19814 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_178296_1 443143.GM18_0908 2.69e-13 70.5 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria 28221|Deltaproteobacteria U SMART AAA ATPase - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22 k59_113276_1 1049564.TevJSym_ad00120 2.61e-92 293.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_61616_1 1122137.AQXF01000001_gene2636 4.01e-07 55.8 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P NHL repeat - - - - - - - - - - - - NHL k59_48482_1 926554.KI912617_gene4712 4.28e-20 86.7 COG3926@1|root,COG3926@2|Bacteria 2|Bacteria S Glycosyl hydrolase 108 - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_35710_1 859657.RPSI07_2271 1.68e-12 66.6 COG3210@1|root,COG3501@1|root,COG3210@2|Bacteria,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria,1K160@119060|Burkholderiaceae 28216|Betaproteobacteria M Rhs element Vgr - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Gp5_C,Phage_GPD k59_35710_2 1297569.MESS2_30021 2.71e-24 99.4 2CMCS@1|root,32SEB@2|Bacteria,1N3SA@1224|Proteobacteria,2UESY@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_35710_3 859657.RPSI07_2273 1.32e-193 545.0 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2VS1K@28216|Betaproteobacteria,1K98W@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2169) - - - - - - - - - - - - DUF2169 k59_138898_1 236097.ADG881_723 2.38e-19 79.7 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1XKHQ@135619|Oceanospirillales 135619|Oceanospirillales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_28946_1 349521.HCH_02778 0.0 1289.0 COG1361@1|root,COG4733@1|root,COG1361@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 1.3.98.1,3.2.1.21 ko:K00226,ko:K05349 ko00240,ko00460,ko00500,ko00940,ko01100,ko01110,map00240,map00460,map00500,map00940,map01100,map01110 M00051 R00026,R01867,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00051,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko00002,ko01000 - GH3 - Big_2,DUF916,Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,NPCBM_assoc,PA14 k59_178298_1 96561.Dole_2430 0.00064 50.1 COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,42Q43@68525|delta/epsilon subdivisions,2WKQF@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_203992_1 192952.MM_1752 2.23e-10 62.0 COG3390@1|root,arCOG02258@2157|Archaea,2XT3R@28890|Euryarchaeota,2N9P2@224756|Methanomicrobia 224756|Methanomicrobia S protein conserved in archaea - - - ko:K09746 - - - - ko00000 - - - - k59_203992_2 222984.JNCS01000003_gene3152 1.82e-30 120.0 COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,23RXQ@183963|Halobacteria 183963|Halobacteria L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins rpa1 - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - - k59_158707_1 553385.JEMF01000072_gene1505 1.59e-08 59.3 COG3177@1|root,COG3177@2|Bacteria 2|Bacteria D Filamentation induced by cAMP protein fic - - - - - - - - - - - - DUF4172,Fic k59_74012_3 1380391.JIAS01000011_gene4677 5.48e-82 258.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,2JRUD@204441|Rhodospirillales 204441|Rhodospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_126834_1 1121448.DGI_2963 9.43e-68 234.0 COG0834@1|root,COG2202@1|root,COG3829@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,1NWNJ@1224|Proteobacteria,43BSA@68525|delta/epsilon subdivisions,2X860@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PAS domain - - - - - - - - - - - - PAS_4 k59_171776_1 1167006.UWK_00372 2.99e-38 144.0 COG2206@1|root,COG2206@2|Bacteria,1RE2G@1224|Proteobacteria,42S6Z@68525|delta/epsilon subdivisions,2WNCP@28221|Deltaproteobacteria,2MNN1@213118|Desulfobacterales 28221|Deltaproteobacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_2706_1 391613.RTM1035_14412 5.97e-07 52.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria,46Q3F@74030|Roseovarius 28211|Alphaproteobacteria M COG2853 Surface lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_2706_2 1049564.TevJSym_an00750 2.28e-107 314.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_61622_1 1049564.TevJSym_ax00180 1.58e-49 170.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1JBWE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M NlpB/DapX lipoprotein bamC - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_61622_2 765912.Thimo_2965 2.1e-140 404.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_61622_3 314278.NB231_12364 1.61e-26 102.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_113285_1 381666.H16_A1621 0.000115 43.9 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_113285_2 381666.H16_A1622 5.72e-92 278.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria,1K39I@119060|Burkholderiaceae 28216|Betaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_109315_1 552811.Dehly_1440 2.7e-78 249.0 COG3666@1|root,COG3666@2|Bacteria,2G998@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_102204_1 335543.Sfum_3097 8.83e-62 216.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MR0U@213462|Syntrophobacterales 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_31114_1 768671.ThimaDRAFT_2793 9.23e-87 270.0 COG3039@1|root,COG3039@2|Bacteria,1P2FY@1224|Proteobacteria,1SRZF@1236|Gammaproteobacteria,1X1EC@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_129292_1 1304885.AUEY01000032_gene1991 2.38e-169 497.0 COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function DUF89 - - - - - - - - - - - - DUF89 k59_193092_2 1049564.TevJSym_as00070 5.68e-188 529.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1J549@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_187642_1 196367.JNFG01000214_gene1294 4.93e-39 143.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_187642_2 1121396.KB892913_gene116 7.69e-38 138.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales 28221|Deltaproteobacteria S Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_154532_2 96561.Dole_2313 5.24e-63 209.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MI74@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma-54 interaction domain - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_51045_1 1049564.TevJSym_ab00050 1.01e-40 144.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding sphX - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_17989_1 1265505.ATUG01000002_gene2201 6.39e-82 264.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM ribonuclease II - - 3.1.13.1 ko:K01147,ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_31357_1 1121035.AUCH01000002_gene1513 5.08e-80 261.0 COG4257@1|root,COG4257@2|Bacteria 2|Bacteria V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - DUF5011,MAM k59_31357_2 634500.EbC_40530 4.01e-83 265.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,3X5EQ@551|Erwinia 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_31357_3 1134474.O59_004242 3.22e-32 130.0 COG5498@1|root,COG5498@2|Bacteria,1R4DU@1224|Proteobacteria,1RR8D@1236|Gammaproteobacteria,1FG6G@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolase family 81 - - - - - - - - - - - - CBM_6,DUF5011,Glyco_hydro_81 k59_173539_2 195253.Syn6312_2673 3.35e-26 106.0 COG0717@1|root,COG0717@2|Bacteria 2|Bacteria F dUTP biosynthetic process - - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_167461_2 753084.F4YCI6_9CAUD 1.13e-11 63.5 4QAIJ@10239|Viruses,4QVZ9@35237|dsDNA viruses no RNA stage,4QPXI@28883|Caudovirales,4QM02@10699|Siphoviridae 10699|Siphoviridae S C-5 cytosine-specific DNA methylase - - - - - - - - - - - - - k59_51059_2 1167006.UWK_00291 1.76e-58 190.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2MIKY@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_129588_1 1249627.D779_0809 7.6e-105 317.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 9 - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_129588_2 748247.AZKH_0594 4.94e-141 412.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KWP5@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_173542_1 1232410.KI421417_gene2744 2.93e-39 139.0 COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,43TEZ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_76479_1 756272.Plabr_0785 1.93e-41 155.0 COG2373@1|root,COG2373@2|Bacteria,2IWRT@203682|Planctomycetes 203682|Planctomycetes S Large extracellular alpha-helical protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl k59_141548_1 314345.SPV1_06149 2.06e-47 159.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria 1224|Proteobacteria F Creatininase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_141548_2 314345.SPV1_06144 5.24e-55 183.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria 1224|Proteobacteria E glutamine synthetase - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_25322_1 1379281.AVAG01000031_gene106 2.36e-129 396.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales 28221|Deltaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_31364_1 391625.PPSIR1_07023 3.69e-19 90.9 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2YVNW@29|Myxococcales 28221|Deltaproteobacteria J 3'-5' exonuclease rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_109498_2 1054213.HMPREF9946_02986 2.02e-214 630.0 COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,2JW4A@204441|Rhodospirillales 204441|Rhodospirillales M Penicillin-Binding Protein C-terminus Family - - - - - - - - - - - - BiPBP_C,Transgly,Transpeptidase k59_109498_3 1248232.BANQ01000059_gene2078 1.62e-56 179.0 COG5646@1|root,COG5646@2|Bacteria,1N03F@1224|Proteobacteria,1SA9M@1236|Gammaproteobacteria,1XX2F@135623|Vibrionales 135623|Vibrionales S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_18003_1 232721.Ajs_4312 1.6e-27 105.0 2ED1F@1|root,336YE@2|Bacteria,1N7TE@1224|Proteobacteria,2VW3Q@28216|Betaproteobacteria 28216|Betaproteobacteria S Family of unknown function (DUF5338) - - - - - - - - - - - - DUF5338 k59_18003_2 1198232.CYCME_3039 1.06e-09 57.8 COG1192@1|root,COG1192@2|Bacteria,1R4EP@1224|Proteobacteria,1S10G@1236|Gammaproteobacteria 1236|Gammaproteobacteria D conjugal transfer protein TraL traL - - - - - - - - - - - ArsA_ATPase,CbiA k59_109499_1 572477.Alvin_2370 1.62e-17 80.9 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_109499_2 343509.SG0133 2.05e-30 110.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0046983,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_31366_1 1049564.TevJSym_bh00300 2.76e-106 316.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1J4ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_199570_1 1049564.TevJSym_aa01930 1.27e-44 166.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_193339_1 1396141.BATP01000020_gene17 1.66e-61 198.0 COG4313@1|root,COG4313@2|Bacteria,46UHV@74201|Verrucomicrobia,2IVEU@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_76481_1 671143.DAMO_1222 7.25e-66 219.0 COG2067@1|root,COG2067@2|Bacteria,2NPN1@2323|unclassified Bacteria 2|Bacteria I Membrane protein involved in aromatic hydrocarbon degradation fadL - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_56710_2 1005048.CFU_3473 1.23e-214 626.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2VP2B@28216|Betaproteobacteria,473G4@75682|Oxalobacteraceae 28216|Betaproteobacteria V Peptidase C39 family cvaB - - ko:K13409 ko02010,ko04626,map02010,map04626 M00339 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_70895_1 909663.KI867150_gene374 5.16e-56 198.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRGB@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_12338_2 477184.KYC_12728 0.0007 45.8 2DZDP@1|root,32V80@2|Bacteria,1NFT2@1224|Proteobacteria,2VVDX@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_199574_2 1453501.JELR01000002_gene1124 3.05e-08 57.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,4649M@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_199574_3 1321781.HMPREF1985_01653 2.4e-08 62.8 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,4H3SB@909932|Negativicutes 909932|Negativicutes L DNA topoisomerase - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_161323_1 1121405.dsmv_1445 9.03e-106 322.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_64198_1 765911.Thivi_3397 2.46e-123 363.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RX39@1236|Gammaproteobacteria,1WXEH@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_18020_1 1121403.AUCV01000043_gene96 2.55e-68 222.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MIGA@213118|Desulfobacterales 28221|Deltaproteobacteria T CheY-like receiver, AAA-type ATPase, and DNA-binding - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_135379_1 933262.AXAM01000001_gene421 2.98e-23 93.6 COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WS27@28221|Deltaproteobacteria,2MJQX@213118|Desulfobacterales 28221|Deltaproteobacteria D DivIVA protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA k59_135379_2 1121405.dsmv_0772 5.59e-60 194.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_4842_1 1279019.ARQK01000044_gene2338 0.000683 42.4 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SYRX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Protoglobin k59_4842_2 1121405.dsmv_0320 1.27e-156 456.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,42PTE@68525|delta/epsilon subdivisions,2WKRZ@28221|Deltaproteobacteria,2MIH0@213118|Desulfobacterales 28221|Deltaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO k59_148262_1 1469245.JFBG01000019_gene1149 9.44e-41 144.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,1RN9U@1236|Gammaproteobacteria,1WW68@135613|Chromatiales 135613|Chromatiales P phosphate binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_83378_1 933262.AXAM01000043_gene1174 7.44e-78 250.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2MIT4@213118|Desulfobacterales 28221|Deltaproteobacteria T Elongation factor Tu domain 2 typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_18022_1 234267.Acid_5170 6.88e-31 118.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 lgtF - - ko:K12984 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 - Glycos_transf_2 k59_115627_1 1123288.SOV_2c02930 2.18e-25 107.0 COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,4H2VF@909932|Negativicutes 909932|Negativicutes P Belongs to the bacterial solute-binding protein 9 family adcA - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_102444_1 517418.Ctha_2293 1.79e-68 221.0 COG5433@1|root,COG5433@2|Bacteria 2|Bacteria L transposase activity tnp4 - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_161325_3 1089552.KI911559_gene2888 9.3e-64 218.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria 28211|Alphaproteobacteria MU RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_148270_1 595460.RRSWK_03372 1.9e-24 109.0 COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IZND@203682|Planctomycetes 203682|Planctomycetes K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_12576_1 1163617.SCD_n01236 9.02e-13 69.3 COG3190@1|root,COG3190@2|Bacteria,1PQ30@1224|Proteobacteria,2VWHP@28216|Betaproteobacteria 28216|Betaproteobacteria N PFAM flagellar biosynthesis protein, FliO fliO - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO k59_12576_2 1049564.TevJSym_aw00550 3.16e-120 349.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,1RMYH@1236|Gammaproteobacteria,1J4NZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_154821_1 933262.AXAM01000004_gene2358 6.58e-32 118.0 COG2203@1|root,COG2203@2|Bacteria,1R6PX@1224|Proteobacteria,42NG9@68525|delta/epsilon subdivisions,2WKCE@28221|Deltaproteobacteria,2MING@213118|Desulfobacterales 28221|Deltaproteobacteria T ANTAR - - - - - - - - - - - - ANTAR,GAF_2 k59_115951_1 316067.Geob_1240 5.7e-131 400.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,43UIU@69541|Desulfuromonadales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF2344,Radical_SAM k59_25629_1 1316927.ATKI01000057_gene4510 8.01e-69 225.0 COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,1RQRZ@1236|Gammaproteobacteria,1YMC2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria V Inner membrane protein CreD creD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06143 - - - - ko00000 - - - CreD k59_25629_2 366394.Smed_1952 5.18e-43 147.0 2C10Z@1|root,32UBU@2|Bacteria,1N4XP@1224|Proteobacteria,2UIIU@28211|Alphaproteobacteria,4BETX@82115|Rhizobiaceae 28211|Alphaproteobacteria S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM k59_71280_1 1123228.AUIH01000091_gene569 1.04e-09 58.9 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_31691_1 1049564.TevJSym_au00220 1.91e-141 421.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_154826_1 665571.STHERM_c17490 6.28e-37 139.0 COG1482@1|root,COG1482@2|Bacteria,2J6VI@203691|Spirochaetes 203691|Spirochaetes G mannose-6-phosphate isomerase, class I manA - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI k59_38823_1 1034943.BN1094_02635 0.000328 48.1 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_206573_5 768671.ThimaDRAFT_0427 7.93e-19 81.3 2CK17@1|root,34BM4@2|Bacteria,1NZWZ@1224|Proteobacteria,1ST1W@1236|Gammaproteobacteria,1X1CW@135613|Chromatiales 135613|Chromatiales S Motility quorum-sensing regulator, toxin of MqsA - - - ko:K13651 - - - - ko00000,ko02048 - - - MqsR_toxin k59_206573_6 1255043.TVNIR_0728 9.4e-46 156.0 COG1396@1|root,COG1396@2|Bacteria,1N3RQ@1224|Proteobacteria,1S3WE@1236|Gammaproteobacteria,1X0XP@135613|Chromatiales 135613|Chromatiales K Antitoxin component of bacterial toxin-antitoxin system, MqsA - - - ko:K13655 - - - - ko00000,ko02048,ko03000 - - - MqsA_antitoxin k59_206573_7 768671.ThimaDRAFT_0425 7.09e-34 123.0 2DHBG@1|root,2ZZ37@2|Bacteria,1RGFW@1224|Proteobacteria,1S5S9@1236|Gammaproteobacteria,1WZU3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_125173_3 13035.Dacsa_2880 6.59e-13 75.5 COG1192@1|root,COG1192@2|Bacteria,1G2GG@1117|Cyanobacteria 1117|Cyanobacteria D involved in chromosome partitioning - - - - - - - - - - - - AAA_31 k59_125173_4 339670.Bamb_6603 3.3e-105 315.0 COG1475@1|root,COG1475@2|Bacteria,1R634@1224|Proteobacteria,2VPF5@28216|Betaproteobacteria 28216|Betaproteobacteria K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - KorB,KorB_C,ParBc k59_163880_2 880072.Desac_2446 4.08e-112 340.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MQ7N@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_21397_1 1122134.KB893651_gene1803 4.68e-60 187.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1XJJW@135619|Oceanospirillales 135619|Oceanospirillales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_112086_1 156889.Mmc1_0042 1.44e-76 237.0 COG1876@1|root,COG1876@2|Bacteria,1RB64@1224|Proteobacteria 1224|Proteobacteria M peptidase M15B and M15C DD-carboxypeptidase VanY - - - - - - - - - - - - VanY k59_131693_1 1049564.TevJSym_ac00800 5.04e-142 413.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1J5J8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_157371_1 1121396.KB893116_gene3147 1.03e-112 335.0 COG0589@1|root,COG0589@2|Bacteria,1N2PD@1224|Proteobacteria,42N6R@68525|delta/epsilon subdivisions,2WM1Y@28221|Deltaproteobacteria,2MMZR@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_66505_1 96561.Dole_1908 5.19e-74 234.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MI0G@213118|Desulfobacterales 28221|Deltaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_47192_1 1049564.TevJSym_ag01000 8.02e-104 313.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_40910_1 439235.Dalk_5190 1.3e-136 405.0 COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_137703_1 207954.MED92_04629 8.76e-07 49.7 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales 135619|Oceanospirillales J SAM-dependent - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_137703_2 103733.JNYO01000079_gene5096 7.68e-41 144.0 COG0693@1|root,COG0693@2|Bacteria,2I8UU@201174|Actinobacteria,4E2IC@85010|Pseudonocardiales 201174|Actinobacteria S ThiJ/PfpI family-like - - - - - - - - - - - - ThiJ_like k59_125180_1 1131553.JIBI01000009_gene1266 1.17e-47 164.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,3734D@32003|Nitrosomonadales 28216|Betaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family nemA GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_131695_1 589865.DaAHT2_1045 1.6e-32 124.0 COG2006@1|root,COG2006@2|Bacteria,1R9FE@1224|Proteobacteria,42QMT@68525|delta/epsilon subdivisions,2WKDC@28221|Deltaproteobacteria,2MJW3@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_92737_1 880073.Calab_2683 3.31e-92 289.0 COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_189878_1 403833.Pmob_1143 1.55e-26 116.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - 2.4.1.270 ko:K21369 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_21405_1 745718.JADT01000007_gene2726 7.77e-22 98.6 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes,1HY1X@117743|Flavobacteriia 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_53570_1 1131553.JIBI01000018_gene516 2.25e-88 307.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_16,TonB_dep_Rec k59_21406_1 1121403.AUCV01000028_gene2399 4.78e-27 105.0 COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,42VJM@68525|delta/epsilon subdivisions,2WRBG@28221|Deltaproteobacteria,2MNWE@213118|Desulfobacterales 28221|Deltaproteobacteria K ROS/MUCR transcriptional regulator protein - - - - - - - - - - - - ROS_MUCR k59_183582_1 439235.Dalk_4767 5.2e-128 379.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M8C@68525|delta/epsilon subdivisions,2WJIB@28221|Deltaproteobacteria,2MJ5E@213118|Desulfobacterales 28221|Deltaproteobacteria K sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,PAS,Sigma54_activat k59_112096_1 880072.Desac_0837 1.06e-71 224.0 COG0685@1|root,COG0685@2|Bacteria,1RBND@1224|Proteobacteria,42QTG@68525|delta/epsilon subdivisions,2WN5D@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_47196_1 587753.EY04_18310 2.4e-80 256.0 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,1S0MS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2169 k59_151076_1 631362.Thi970DRAFT_01390 5.21e-10 55.1 2E3CD@1|root,32YBP@2|Bacteria,1N8PD@1224|Proteobacteria,1SCSK@1236|Gammaproteobacteria,1WZ7C@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_151076_2 1049564.TevJSym_aw00240 4.12e-40 141.0 COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_144645_1 1049564.TevJSym_at00190 3.91e-67 208.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1J5X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_118724_1 1110502.TMO_1586 2.22e-51 171.0 COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,2TTCH@28211|Alphaproteobacteria,2JQCT@204441|Rhodospirillales 204441|Rhodospirillales S COG2041 Sulfite oxidase and related enzymes - - - - - - - - - - - - Oxidored_molyb k59_8309_2 670292.JH26_28480 2.21e-17 82.4 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_29,HTH_32,HTH_33 k59_183585_1 2340.JV46_14270 1.73e-33 123.0 COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP synthase subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_92750_1 1040989.AWZU01000004_gene7043 8.72e-09 57.8 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,3JUK3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_21417_1 1049564.TevJSym_ag00340 1.17e-47 166.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_21417_2 1049564.TevJSym_ag00350 9.21e-71 215.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1J64W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Redox protein regulator of disulfide bond formation yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_118727_2 1396418.BATQ01000110_gene4754 1.14e-22 97.8 COG3637@1|root,COG3637@2|Bacteria,46W5R@74201|Verrucomicrobia,2IU7G@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - Phenol_MetA_deg k59_34299_1 160492.XF_a0042 7.83e-16 76.3 COG3504@1|root,COG3504@2|Bacteria,1MVEF@1224|Proteobacteria,1RPUB@1236|Gammaproteobacteria,1X5JV@135614|Xanthomonadales 135614|Xanthomonadales U Conjugal transfer protein - - - ko:K20532 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - CagX k59_34299_2 76114.p2B7 1.18e-31 117.0 2AXJ9@1|root,31PJ9@2|Bacteria,1RIA1@1224|Proteobacteria,2VTH3@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Conjugal transfer, TrbH - - - - - - - - - - - - TrbH k59_34299_3 76114.p2B8 8e-45 162.0 COG2948@1|root,COG2948@2|Bacteria,1MU7U@1224|Proteobacteria,2VJA2@28216|Betaproteobacteria,2KXAH@206389|Rhodocyclales 206389|Rhodocyclales U Type IV secretory pathway, VirB10 - - - ko:K20533 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - TrbI k59_112101_1 643562.Daes_0742 2.81e-11 70.1 COG1315@1|root,COG1315@2|Bacteria,1R40D@1224|Proteobacteria,42MFE@68525|delta/epsilon subdivisions,2WP8Y@28221|Deltaproteobacteria,2M9CI@213115|Desulfovibrionales 28221|Deltaproteobacteria L Pfam:DUF342 - - - ko:K09749 - - - - ko00000 - - - FapA k59_137720_1 96561.Dole_0148 2.64e-60 204.0 COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Transglut_core k59_47209_1 472759.Nhal_3019 1.12e-49 173.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales 135613|Chromatiales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_47209_2 580332.Slit_1358 2.39e-29 114.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,44WHF@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_21422_1 933262.AXAM01000060_gene2888 8.71e-38 135.0 COG2204@1|root,COG2204@2|Bacteria,1MYQ1@1224|Proteobacteria,42TBS@68525|delta/epsilon subdivisions,2WNQA@28221|Deltaproteobacteria,2MJTT@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_125203_1 1049564.TevJSym_au00310 1.24e-12 70.5 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1J4CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O peptidyl-prolyl isomerase ppiD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_125203_2 1049564.TevJSym_au00320 6.84e-146 415.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1J5YR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECUMN_1333.ECUMN_1592 adh_short_C2 k59_112105_1 1123401.JHYQ01000015_gene1428 2.96e-125 365.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Required for the activity of the bacterial periplasmic transport system of putrescine potD - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 k59_157372_1 1049564.TevJSym_ab01430 1.14e-102 304.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1J72J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Peptidase C26 - - - - - - - - - - - - GATase k59_157372_2 318161.Sden_2376 1.01e-08 61.2 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S66I@1236|Gammaproteobacteria,2QBJI@267890|Shewanellaceae 1236|Gammaproteobacteria S ErfK YbiS YcfS YnhG IV02_27405 - - - - - - - - - - - YkuD k59_157372_4 1049564.TevJSym_bw00100 1.21e-74 227.0 2C20N@1|root,32SGJ@2|Bacteria,1N3M9@1224|Proteobacteria,1S9VG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_118732_1 1049564.TevJSym_ar00430 9.82e-219 637.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4MB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_53576_1 34007.IT40_20190 2.55e-112 338.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2PY5J@265|Paracoccus 28211|Alphaproteobacteria C Catalyzes the formation of succinate from succinate semialdehyde gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_53576_4 1232410.KI421415_gene2933 2.11e-43 157.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_21429_1 1121451.DESAM_21372 8.66e-14 77.4 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M83U@213115|Desulfovibrionales 28221|Deltaproteobacteria KT SMART protein phosphatase 2C domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,SpoIIE k59_170890_1 933262.AXAM01000022_gene3229 3.21e-67 219.0 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM ResB family protein - - - ko:K07399 - - - - ko00000 - - - ResB k59_21663_1 483219.LILAB_03850 1.06e-49 175.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42PI0@68525|delta/epsilon subdivisions,2WJ79@28221|Deltaproteobacteria,2YUU7@29|Myxococcales 28221|Deltaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_2 k59_125451_1 67267.JNXT01000015_gene3729 1.08e-09 62.4 COG0823@1|root,COG0823@2|Bacteria,2IC0F@201174|Actinobacteria 201174|Actinobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40 k59_14614_2 1322246.BN4_10446 1.92e-12 68.2 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2MCBQ@213115|Desulfovibrionales 28221|Deltaproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_118978_1 697282.Mettu_0993 9.86e-74 231.0 COG3385@1|root,COG3385@2|Bacteria,1NIWM@1224|Proteobacteria,1S5FT@1236|Gammaproteobacteria,1XFX0@135618|Methylococcales 135618|Methylococcales L PFAM Transposase - - - - - - - - - - - - DDE_5 k59_131940_3 426117.M446_6814 8.46e-167 497.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2TR0H@28211|Alphaproteobacteria,1JQZP@119045|Methylobacteriaceae 28211|Alphaproteobacteria KQ Sigma-54 interaction domain acoR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,HTH_Crp_2,Sigma54_activat k59_177139_6 1042876.PPS_4140 2.39e-09 61.2 COG2885@1|root,COG2885@2|Bacteria,1RGHU@1224|Proteobacteria,1S5H8@1236|Gammaproteobacteria,1YVWP@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,TSP_3 k59_177139_7 948106.AWZT01000012_gene1491 6.9e-31 115.0 COG0741@1|root,COG0741@2|Bacteria,1MZU4@1224|Proteobacteria,2VU6M@28216|Betaproteobacteria,1K54Y@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic hpa2 - - - - - - - - - - - SLT k59_177139_8 251229.Chro_2279 2.26e-35 128.0 COG0454@1|root,COG0456@2|Bacteria,1GCIE@1117|Cyanobacteria,3VKF6@52604|Pleurocapsales 1117|Cyanobacteria K PFAM Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_10 k59_177139_9 522306.CAP2UW1_0885 1.48e-22 90.1 COG4453@1|root,COG4453@2|Bacteria,1N7K8@1224|Proteobacteria,2VTUT@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_177139_10 2340.JV46_07750 2.72e-54 171.0 COG4679@1|root,COG4679@2|Bacteria,1MZ3N@1224|Proteobacteria,1S6QV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage-related protein - - - - - - - - - - - - Gp49 k59_34521_1 395019.Bmul_3210 1.18e-64 204.0 COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2VIZ5@28216|Betaproteobacteria,1K2IT@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.1.2.41,4.2.1.101 ko:K18383 ko00360,ko01100,ko01110,map00360,map01100,map01110 - R05772,R05773 RC00307,RC01468,RC01828 ko00000,ko00001,ko01000 - - - ECH_1 k59_34521_2 1123060.JONP01000036_gene3571 2.92e-09 57.8 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRI3@28211|Alphaproteobacteria,2JW87@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - 1.2.1.67 ko:K21802 ko00627,ko01120,map00627,map01120 - R05699 RC00075 ko00000,ko00001,ko01000 - - - Aldedh k59_41165_1 768671.ThimaDRAFT_0093 4.41e-103 315.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_53761_1 555079.Toce_1753 2.47e-45 156.0 COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia 186801|Clostridia C binding domain protein - - - - - - - - - - - - Fer4,Fer4_6 k59_170894_1 1121943.KB899994_gene1066 6.21e-217 608.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RN9K@1236|Gammaproteobacteria,1XRAV@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_21673_1 1265505.ATUG01000003_gene388 1e-14 67.0 COG1908@1|root,COG1908@2|Bacteria,1NGSG@1224|Proteobacteria,42XN0@68525|delta/epsilon subdivisions,2WTGE@28221|Deltaproteobacteria,2MM9B@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_178273_1 1469613.JT55_00105 7.03e-48 170.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,3FCGV@34008|Rhodovulum 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_67989_1 96561.Dole_0647 2.91e-46 163.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_67989_2 1167006.UWK_03138 5.52e-09 55.8 COG3937@1|root,COG3937@2|Bacteria,1N4MU@1224|Proteobacteria,42UUE@68525|delta/epsilon subdivisions,2WQEZ@28221|Deltaproteobacteria,2MKJF@213118|Desulfobacterales 28221|Deltaproteobacteria S granule-associated protein - - - - - - - - - - - - Phasin k59_2671_1 1049564.TevJSym_bv00110 2.87e-17 82.4 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1J5PE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_2671_2 768671.ThimaDRAFT_4841 1.96e-10 62.4 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_184923_1 1322246.BN4_20079 2.38e-67 227.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria,2M8UY@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_87318_2 933262.AXAM01000017_gene3138 2.87e-68 210.0 COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,42RM4@68525|delta/epsilon subdivisions,2WNU8@28221|Deltaproteobacteria,2MJYM@213118|Desulfobacterales 28221|Deltaproteobacteria K AsnC-type helix-turn-helix domain nirD - - - - - - - - - - - HTH_AsnC-type k59_42519_1 1121405.dsmv_2940 1.52e-30 115.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,42QNG@68525|delta/epsilon subdivisions,2WK8B@28221|Deltaproteobacteria,2MJ8V@213118|Desulfobacterales 28221|Deltaproteobacteria K UTRA domain - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_42519_2 1232437.KL662025_gene932 7.02e-40 142.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2MHP8@213118|Desulfobacterales 28221|Deltaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_197126_1 338963.Pcar_3052 3.03e-50 176.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_138879_1 765912.Thimo_1199 3.23e-147 435.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales 135613|Chromatiales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_138879_2 1049564.TevJSym_at00750 6.29e-36 125.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,1RPVD@1236|Gammaproteobacteria,1J5R6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050355 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - iJN746.PP_0538,iPC815.YPO3521 Pyrophosphatase k59_35689_1 765913.ThidrDRAFT_0569 1.36e-110 332.0 COG0720@1|root,COG0720@2|Bacteria,1NNVS@1224|Proteobacteria 1224|Proteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_191178_1 671143.DAMO_1319 5.58e-67 241.0 COG0457@1|root,COG3712@1|root,COG4773@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4773@2|Bacteria 2|Bacteria P Receptor - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - FecR,Plug,STN,TPR_16,TPR_8,TonB_dep_Rec k59_197129_1 279714.FuraDRAFT_2335 4.98e-96 298.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,2KQEB@206351|Neisseriales 206351|Neisseriales T PrkA AAA domain prkA - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_132982_1 880072.Desac_1111 6.27e-207 588.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MR7D@213462|Syntrophobacterales 28221|Deltaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_158678_1 439235.Dalk_3803 7.16e-59 198.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2MHUE@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_126796_1 1158150.KB906247_gene2330 8.95e-75 238.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales 135613|Chromatiales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_126796_2 1278309.KB907100_gene2175 1.11e-187 533.0 COG2199@1|root,COG3706@2|Bacteria,1N7HG@1224|Proteobacteria,1S2NP@1236|Gammaproteobacteria,1XJSG@135619|Oceanospirillales 135619|Oceanospirillales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_126796_3 493475.GARC_5049 1.33e-67 216.0 COG3916@1|root,COG3916@2|Bacteria,1RCQC@1224|Proteobacteria,1S3K2@1236|Gammaproteobacteria,465JC@72275|Alteromonadaceae 1236|Gammaproteobacteria QT Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_126796_5 287.DR97_215 2.21e-64 200.0 COG2703@1|root,COG2703@2|Bacteria,1RI40@1224|Proteobacteria,1S60H@1236|Gammaproteobacteria,1YGAC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_61588_1 118161.KB235919_gene6400 3.13e-26 105.0 COG3415@1|root,COG3415@2|Bacteria,1GEDQ@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_178275_1 1049564.TevJSym_be00310 5.8e-117 349.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RSPM@1236|Gammaproteobacteria,1J5AH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_178275_2 1134474.O59_003661 1.6e-17 83.2 COG3134@1|root,COG3134@2|Bacteria,1QSR8@1224|Proteobacteria,1RW9B@1236|Gammaproteobacteria,1FHC4@10|Cellvibrio 1236|Gammaproteobacteria S Outer membrane lipoprotein - - - - - - - - - - - - - k59_120205_1 472759.Nhal_1154 0.0 900.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WX0W@135613|Chromatiales 135613|Chromatiales N transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_120205_2 323261.Noc_2142 9.39e-38 135.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WX7H@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_42523_1 1049564.TevJSym_ag00110 5.84e-48 165.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_42523_2 1336245.JAGO01000010_gene687 2.7e-87 266.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,1XIMF@135619|Oceanospirillales 135619|Oceanospirillales S metal-binding protein - - - - - - - - - - - - NIF3 k59_106780_1 1121405.dsmv_1993 2.43e-114 351.0 COG0377@1|root,COG0649@1|root,COG0852@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,COG0852@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2MIC7@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoBCD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,Oxidored_q6 k59_81078_1 1004785.AMBLS11_12410 2.69e-68 239.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,1RPEA@1236|Gammaproteobacteria,46874@72275|Alteromonadaceae 1236|Gammaproteobacteria L protein, homolog of phage Mu protein gp30 - - - - - - - - - - - - Phage_Mu_F k59_120207_1 1304885.AUEY01000044_gene226 3.97e-87 263.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MJHB@213118|Desulfobacterales 28221|Deltaproteobacteria T helix_turn_helix, Lux Regulon - - - ko:K02479 - - - - ko00000,ko02022 - - - GerE,Response_reg k59_203978_1 933262.AXAM01000034_gene1558 1.42e-60 196.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2MITP@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_113264_3 1049564.TevJSym_ak00960 1.17e-61 197.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1J6KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 5-FTHF_cyc-lig k59_184939_1 335543.Sfum_1795 1.93e-123 367.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,2MRHE@213462|Syntrophobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_67999_1 572479.Hprae_0784 8.02e-62 214.0 COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WA6D@53433|Halanaerobiales 186801|Clostridia J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k59_204146_3 252305.OB2597_13438 0.000859 40.8 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2TRT7@28211|Alphaproteobacteria,2PDUJ@252301|Oceanicola 28211|Alphaproteobacteria O C-terminal, D2-small domain, of ClpB protein clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_158880_1 373903.Hore_01680 1.52e-71 231.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WADU@53433|Halanaerobiales 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_74174_1 1122201.AUAZ01000023_gene2989 8.12e-243 719.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,1RY2M@1236|Gammaproteobacteria,46772@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3 k59_127072_1 1220534.B655_0664 3.73e-12 72.4 COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,23PHJ@183925|Methanobacteria 183925|Methanobacteria P TIGRFAM Potassium uptake protein TrkH - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_35890_1 2340.JV46_26410 1.39e-09 58.2 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1J4KU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_35890_2 2340.JV46_26420 8.44e-183 516.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1JBV9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_152328_2 395961.Cyan7425_3096 1.92e-174 501.0 COG3328@1|root,COG3328@2|Bacteria,1G3YG@1117|Cyanobacteria 1117|Cyanobacteria L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_204147_1 1049564.TevJSym_al00480 5.57e-38 132.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1J5E2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_35891_1 519989.ECTPHS_05616 1.94e-07 54.7 COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1WXIG@135613|Chromatiales 135613|Chromatiales N Flagellar rod assembly protein muramidase FlgJ - - - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase,Rod-binding k59_94714_2 236097.ADG881_1512 2.59e-50 167.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales 135619|Oceanospirillales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_61822_1 1121396.KB892954_gene3520 4.51e-60 189.0 COG3791@1|root,COG3791@2|Bacteria,1PSHI@1224|Proteobacteria,42WTX@68525|delta/epsilon subdivisions,2WT7S@28221|Deltaproteobacteria,2MNCF@213118|Desulfobacterales 28221|Deltaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_106994_1 1049564.TevJSym_as00320 8.4e-17 79.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function Z012_09445 - - - - - - - - - - - Peptidase_M48 k59_106994_2 1049564.TevJSym_as00330 7.9e-118 346.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1J4QV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S stress-induced protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_120400_1 1121456.ATVA01000011_gene1345 1.63e-181 530.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg k59_191306_1 177437.HRM2_34450 6.37e-20 86.7 2CI36@1|root,32S77@2|Bacteria,1N2YG@1224|Proteobacteria,42UEU@68525|delta/epsilon subdivisions,2WQZY@28221|Deltaproteobacteria,2MKF2@213118|Desulfobacterales 28221|Deltaproteobacteria S Chemotaxis phosphatase CheX - - - - - - - - - - - - CheX k59_191306_2 883158.HMPREF9140_01566 4.15e-12 68.9 COG0457@1|root,COG0642@1|root,COG0745@1|root,COG2207@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,4NDXU@976|Bacteroidetes,2FMVV@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,PEPcase,Reg_prop,Response_reg,TPR_12,TPR_7,TPR_8,Y_Y_Y k59_29125_1 1049564.TevJSym_by00030 4.9e-291 820.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1J4T4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_74185_1 572477.Alvin_0252 3.42e-18 83.2 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_22863_2 443255.SCLAV_5614 2.45e-316 999.0 COG0300@1|root,COG1020@1|root,COG3321@1|root,COG0300@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - ko:K15395 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_22863_3 1157634.KB912999_gene4688 0.0 957.0 COG1020@1|root,COG1020@2|Bacteria 2|Bacteria Q D-alanine [D-alanyl carrier protein] ligase activity - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,NAD_binding_4,PP-binding,ketoacyl-synt k59_22863_4 159087.Daro_1440 1.36e-17 84.0 COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2VJY3@28216|Betaproteobacteria 28216|Betaproteobacteria E abc-type branched-chain amino acid transport - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6,TAT_signal k59_22863_5 944435.AXAJ01000001_gene27 1.86e-139 448.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1KIH6@119060|Burkholderiaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_146045_2 1249627.D779_3422 4.96e-142 410.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,1WVWJ@135613|Chromatiales 135613|Chromatiales E ABC transporter, urea - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_178520_2 857087.Metme_1124 2.08e-34 134.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_158896_1 706587.Desti_2062 1.45e-47 162.0 COG0662@1|root,COG1426@1|root,COG0662@2|Bacteria,COG1426@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - - - - - - - - - - Cupin_2,HTH_19,HTH_25,HTH_3,HTH_31 k59_191308_1 1049564.TevJSym_aw00130 3.68e-115 343.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_191308_2 2340.JV46_15460 1.69e-14 70.9 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - - - - - - - - - - - Nitrate_red_gam k59_165203_1 546273.VEIDISOL_01559 1.29e-47 161.0 COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,4H20D@909932|Negativicutes 909932|Negativicutes M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_165203_2 335543.Sfum_2075 1.7e-56 191.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_107000_1 519989.ECTPHS_14156 1.07e-63 198.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_61828_2 457425.XNR_3644 8.28e-17 80.1 COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria 201174|Actinobacteria L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_146048_1 1499967.BAYZ01000154_gene1466 1.54e-70 232.0 COG0699@1|root,COG0699@2|Bacteria 2|Bacteria T ATPase. Has a role at an early stage in the morphogenesis of the spore coat - - - - - - - - - - - - Dynamin_N k59_15727_1 868864.Dester_0355 5.45e-19 94.0 COG3005@1|root,COG3005@2|Bacteria,2G4KY@200783|Aquificae 200783|Aquificae C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_68272_1 933262.AXAM01000029_gene2733 6.45e-12 62.4 2EGQG@1|root,33AGM@2|Bacteria,1NHQK@1224|Proteobacteria,42X2Y@68525|delta/epsilon subdivisions,2WSU5@28221|Deltaproteobacteria,2MMG3@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4911) - - - - - - - - - - - - DUF4911 k59_152340_1 933262.AXAM01000030_gene826 3.2e-58 199.0 2EYTB@1|root,33S0H@2|Bacteria,1NRWZ@1224|Proteobacteria,42Y5M@68525|delta/epsilon subdivisions,2WU9Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_133200_1 485915.Dret_2002 1.43e-79 250.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_165205_2 1122919.KB905638_gene378 1.44e-76 236.0 COG3335@1|root,COG3335@2|Bacteria,1UZI4@1239|Firmicutes,4HRKC@91061|Bacilli,26SVE@186822|Paenibacillaceae 91061|Bacilli L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_165205_3 449447.MAE_20930 6.08e-15 72.0 COG3415@1|root,COG3415@2|Bacteria,1GA2F@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_113446_1 378806.STAUR_6173 1.29e-114 364.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions,2X5HM@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions O Peptidase inhibitor I9 - - 3.4.21.111 ko:K20754 - - - - ko00000,ko01000,ko01002 - - - Inhibitor_I9,Peptidase_S8 k59_54862_1 1121403.AUCV01000013_gene3954 9.07e-81 266.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MHXW@213118|Desulfobacterales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_100171_1 933262.AXAM01000086_gene2642 4.28e-19 82.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42R2A@68525|delta/epsilon subdivisions,2WMUK@28221|Deltaproteobacteria,2MJJX@213118|Desulfobacterales 28221|Deltaproteobacteria H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_100171_2 1304885.AUEY01000020_gene3496 9.39e-79 239.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,42S2E@68525|delta/epsilon subdivisions,2WMT9@28221|Deltaproteobacteria,2MITJ@213118|Desulfobacterales 28221|Deltaproteobacteria F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_129147_4 1123392.AQWL01000002_gene2106 9.53e-60 199.0 COG3637@1|root,COG3637@2|Bacteria,1RHUP@1224|Proteobacteria 1224|Proteobacteria M Domain of unknown function (DUF3943) VP1938 - - - - - - - - - - - DUF3943,OMP_b-brl k59_154026_1 1163617.SCD_n02546 1.29e-57 203.0 COG1629@1|root,COG4771@2|Bacteria,1QWR1@1224|Proteobacteria,2WI6D@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_37993_1 706587.Desti_2954 1.32e-92 289.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MR2Y@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_122734_1 768671.ThimaDRAFT_1572 1.16e-49 171.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_122734_2 765911.Thivi_1840 8.22e-237 662.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_122734_3 983545.Glaag_3586 1.23e-56 179.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,466ZQ@72275|Alteromonadaceae 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_173139_3 1049564.TevJSym_bc00200 1.52e-105 309.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1J5UI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c13120,ic_1306.c1370 Thymidylate_kin k59_154032_2 395961.Cyan7425_0788 5.91e-08 57.4 COG4191@1|root,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,3KJHE@43988|Cyanothece 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_76080_1 644968.DFW101_2946 1.31e-50 177.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,42P15@68525|delta/epsilon subdivisions,2WK8D@28221|Deltaproteobacteria,2MASN@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_7,rve k59_70575_1 335543.Sfum_0110 1.32e-52 183.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2MQH0@213462|Syntrophobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_70575_2 1125863.JAFN01000001_gene1681 1.7e-07 53.1 COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,42SAA@68525|delta/epsilon subdivisions,2WPCM@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM methyltransferase - - 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS,Methyltransf_31 k59_37999_1 298386.PBPRA3548 4.09e-67 212.0 COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,1SZQS@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_56361_1 45351.EDO37845 0.000264 49.7 2F0B0@1|root,2T1HC@2759|Eukaryota,3AUYV@33154|Opisthokonta,3C5AX@33208|Metazoa 33208|Metazoa S DOMON domain - - - - - - - - - - - - DOMON k59_102034_1 1121405.dsmv_2727 1.21e-252 714.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_89343_1 1122962.AULH01000001_gene1700 2.19e-05 51.6 COG4963@1|root,COG4963@2|Bacteria,1R9GH@1224|Proteobacteria,2U3XM@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Pilus assembly protein - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,Response_reg k59_89343_2 1121939.L861_08770 1.27e-13 72.8 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1XN1M@135619|Oceanospirillales 135619|Oceanospirillales U COG4962 Flp pilus assembly protein, ATPase CpaF - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_154033_2 1499967.BAYZ01000017_gene6233 4.77e-54 177.0 COG0693@1|root,COG0693@2|Bacteria 2|Bacteria S protein deglycation - - - - - - - - - - - - DJ-1_PfpI,ThiJ_like k59_199157_1 1232410.KI421425_gene1549 5.52e-55 195.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_24920_1 1121448.DGI_1023 0.000585 43.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,43DF9@68525|delta/epsilon subdivisions 1224|Proteobacteria T diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,HATPase_c,PAS_3,PAS_4,PAS_9 k59_24920_2 1479237.JMLY01000001_gene300 3.66e-99 298.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,4672Q@72275|Alteromonadaceae 1236|Gammaproteobacteria S ATPase (AAA superfamily) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_24920_3 1255043.TVNIR_3186 1.59e-25 105.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1X2QU@135613|Chromatiales 135613|Chromatiales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_187269_1 1122201.AUAZ01000004_gene3440 2.91e-88 275.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,4659W@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1061 DNA or RNA helicases of superfamily II - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_205874_1 931626.Awo_c07580 3.51e-52 179.0 COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia 186801|Clostridia S PFAM ferredoxin-dependent glutamate synthase - - - - - - - - - - - - Glu_synthase k59_96833_1 477228.YO5_06942 5.96e-15 71.6 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1Z38X@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU COG4968 Tfp pilus assembly protein PilE pilE - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_102047_1 439235.Dalk_5090 3.87e-69 233.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_11936_1 713587.THITH_06995 8.46e-17 80.5 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales 135613|Chromatiales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_45303_1 335543.Sfum_4069 1.12e-79 248.0 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_154041_1 96561.Dole_2551 1.3e-175 503.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2MHNI@213118|Desulfobacterales 28221|Deltaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_96834_1 1049564.TevJSym_be00280 7.4e-120 360.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1J55B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2885 Glu_cys_ligase k59_45305_1 1441629.PCH70_25300 1.56e-60 210.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - ko:K15659 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_83048_1 1134474.O59_000843 9.26e-21 95.1 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,1S133@1236|Gammaproteobacteria,1FFU4@10|Cellvibrio 1236|Gammaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - - k59_83048_2 1129794.C427_0652 2.27e-43 149.0 COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria,4681G@72275|Alteromonadaceae 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_129166_1 1049564.TevJSym_aw00450 3.17e-42 152.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J50D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0643 Chemotaxis protein histidine kinase and related kinases cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_129166_2 1283300.ATXB01000001_gene893 4.88e-48 164.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,1RNG2@1236|Gammaproteobacteria,1XGBX@135618|Methylococcales 135618|Methylococcales NT Chemotaxis phosphatase, CheZ - - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_205883_2 1049564.TevJSym_aq00400 1.21e-169 478.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_129168_1 1336234.JAGN01000042_gene485 4.32e-79 261.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,27F9T@186828|Carnobacteriaceae 91061|Bacilli L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_50624_1 1504981.KO116_3665 2.81e-07 55.8 COG4970@1|root,COG4970@2|Bacteria,1NGHS@1224|Proteobacteria,1SGGC@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU COG4970 Tfp pilus assembly protein FimT fimT - - ko:K08084,ko:K08085 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_173173_1 264732.Moth_1606 5.57e-134 394.0 COG0247@1|root,COG0247@2|Bacteria,1TSC1@1239|Firmicutes,24B10@186801|Clostridia,42FPP@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S dicluster domain hmeD - - - - - - - - - - - CCG,Fer4_8 k59_115483_1 1121875.KB907546_gene2238 2.49e-119 352.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_4720_1 765914.ThisiDRAFT_1039 4.03e-45 165.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_31234_1 1121013.P873_05425 5.38e-15 78.2 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1X377@135614|Xanthomonadales 135614|Xanthomonadales I desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_31234_2 713587.THITH_05495 3.54e-53 173.0 COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria,1SQTD@1236|Gammaproteobacteria 1236|Gammaproteobacteria DO anaphase-promoting complex-dependent catabolic process - - - - - - - - - - - - - k59_31234_4 765910.MARPU_14020 4.23e-10 66.2 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WXQZ@135613|Chromatiales 135613|Chromatiales L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_89581_2 933262.AXAM01000048_gene2601 2.81e-42 157.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_38307_1 123214.PERMA_1470 1.35e-71 231.0 COG0146@1|root,COG0146@2|Bacteria,2G3NG@200783|Aquificae 200783|Aquificae EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_135197_1 1403819.BATR01000195_gene6595 2.74e-105 324.0 COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia 74201|Verrucomicrobia L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_31245_2 1049564.TevJSym_ak00200 7.74e-49 164.0 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,1S5WF@1236|Gammaproteobacteria,1J6P4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0227) yqiA GO:0003674,GO:0003824,GO:0016787,GO:0016788 - ko:K07000 - - - - ko00000 - - - UPF0227 k59_25170_1 1123401.JHYQ01000007_gene544 4.84e-10 58.9 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,462Q6@72273|Thiotrichales 72273|Thiotrichales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_76355_1 1385935.N836_20955 3.74e-195 550.0 COG1156@1|root,COG1156@2|Bacteria,1G2WR@1117|Cyanobacteria,1H9DX@1150|Oscillatoriales 1117|Cyanobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_154370_1 1121413.JMKT01000009_gene1799 8.61e-31 117.0 COG0189@1|root,COG0189@2|Bacteria,1MWQA@1224|Proteobacteria,43B1R@68525|delta/epsilon subdivisions,2X6FW@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ RimK domain protein ATP-grasp - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_109357_3 1545915.JROG01000004_gene2032 5.23e-26 99.8 COG0640@1|root,COG0640@2|Bacteria,1N2P4@1224|Proteobacteria,2UFNP@28211|Alphaproteobacteria,2K5QX@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 k59_109357_4 1299327.I546_4374 2.47e-51 183.0 COG3000@1|root,COG3000@2|Bacteria,2IRWJ@201174|Actinobacteria 201174|Actinobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_109357_7 196367.JNFG01000199_gene3296 0.000807 49.3 COG3315@1|root,COG3315@2|Bacteria,1R810@1224|Proteobacteria,2WEN5@28216|Betaproteobacteria,1KHT0@119060|Burkholderiaceae 28216|Betaproteobacteria Q Leucine carboxyl methyltransferase - - - - - - - - - - - - LCM k59_89594_1 207559.Dde_3641 4.78e-64 216.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2M8PA@213115|Desulfovibrionales 28221|Deltaproteobacteria P transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_17840_1 1129374.AJE_02506 2.22e-75 234.0 2DNYB@1|root,32ZS8@2|Bacteria,1RF1E@1224|Proteobacteria,1S5M8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RloB-like protein - - - - - - - - - - - - RloB k59_17840_2 653733.Selin_2306 6.3e-180 515.0 COG1106@1|root,COG1106@2|Bacteria 2|Bacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K06926 - - - - ko00000 - - - AAA_21 k59_187526_1 1123393.KB891316_gene1510 3.82e-76 244.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,1KSI6@119069|Hydrogenophilales 119069|Hydrogenophilales S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_64062_1 639030.JHVA01000001_gene1589 1.6e-55 184.0 2CDI3@1|root,3416N@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_109367_1 1229780.BN381_10287 2.92e-17 84.0 COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,3UXDU@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_141405_1 338963.Pcar_2244 8.24e-108 338.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_180538_1 472759.Nhal_1079 3.58e-88 270.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria 1224|Proteobacteria Q Multi-copper - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_206126_1 498211.CJA_0327 2.03e-43 144.0 COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria,1S3V3@1236|Gammaproteobacteria 1236|Gammaproteobacteria FJ deaminase cdd - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k59_199419_1 472759.Nhal_3175 5.43e-44 154.0 COG1397@1|root,COG1397@2|Bacteria,1PMP6@1224|Proteobacteria,1TK5S@1236|Gammaproteobacteria,1WZKE@135613|Chromatiales 135613|Chromatiales O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_109372_1 472759.Nhal_3536 1.62e-20 97.1 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_193216_1 349124.Hhal_1707 1.76e-131 397.0 COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,1S0XD@1236|Gammaproteobacteria,1WXNC@135613|Chromatiales 135613|Chromatiales L DEAD DEAH box - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_135220_1 1407650.BAUB01000001_gene109 1.19e-19 90.1 COG1853@1|root,COG1853@2|Bacteria,1G2RV@1117|Cyanobacteria,1GYSV@1129|Synechococcus 1117|Cyanobacteria S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - - - - - - - - - - Flavin_Reduct k59_31274_1 357808.RoseRS_4186 6.66e-16 81.6 COG0607@1|root,COG0659@1|root,COG0607@2|Bacteria,COG0659@2|Bacteria,2G83D@200795|Chloroflexi,3764C@32061|Chloroflexia 32061|Chloroflexia P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - Rhodanese,STAS,Sulfate_transp k59_175016_2 1244869.H261_12401 7.97e-95 288.0 COG1410@1|root,COG1410@2|Bacteria,1NSVT@1224|Proteobacteria 1224|Proteobacteria E Pterin binding enzyme - - - - - - - - - - - - Pterin_bind k59_175016_3 1232410.KI421424_gene1698 1.07e-55 189.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_123178_1 1254432.SCE1572_13250 2.41e-60 217.0 COG0001@1|root,COG0604@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0604@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,43E1T@68525|delta/epsilon subdivisions,2X7HJ@28221|Deltaproteobacteria,2Z3M9@29|Myxococcales 28221|Deltaproteobacteria Q Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_90779_1 519989.ECTPHS_07331 1.96e-51 183.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_64860_1 768671.ThimaDRAFT_4604 3.21e-119 377.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_64863_1 439235.Dalk_0564 6.5e-76 243.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2MIPJ@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_71353_1 933262.AXAM01000061_gene1666 2.75e-94 300.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_162084_1 713586.KB900536_gene696 2.01e-48 172.0 COG4961@1|root,COG4961@2|Bacteria 2|Bacteria U PFAM TadE family protein - - - - - - - - - - - - Tad,TadE k59_110237_2 1122611.KB904029_gene5399 1.85e-52 176.0 COG1309@1|root,COG1309@2|Bacteria,2IIK3@201174|Actinobacteria,4EFUC@85012|Streptosporangiales 201174|Actinobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG k59_110237_4 1218352.B597_020850 4.4e-55 186.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1Z3VI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Outer membrane efflux protein - - - ko:K18300 - M00641 - - ko00000,ko00002,ko01504,ko02000 1.B.17 - - OEP k59_200950_1 933262.AXAM01000055_gene1248 1.85e-47 158.0 COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,42R2R@68525|delta/epsilon subdivisions,2WMSJ@28221|Deltaproteobacteria,2MJRA@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulator, AsnC family - - - - - - - - - - - - HTH_24,HTH_AsnC-type k59_155570_3 1346791.M529_11985 1e-22 96.3 COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,2UH3T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4381 Mu-like prophage protein gp46 - - - - - - - - - - - - GP46 k59_155570_5 870967.VIS19158_06225 1.04e-08 61.2 COG4384@1|root,COG4384@2|Bacteria,1MZ4H@1224|Proteobacteria,1S5VZ@1236|Gammaproteobacteria,1XYM5@135623|Vibrionales 135623|Vibrionales S Bacteriophage Mu Gp45 protein - - - - - - - - - - - - Phage_Mu_Gp45 k59_155570_7 690850.Desaf_0702 9.02e-26 116.0 COG4228@1|root,COG4228@2|Bacteria,1R4HU@1224|Proteobacteria,42Y6H@68525|delta/epsilon subdivisions,2WUJZ@28221|Deltaproteobacteria,2MAWZ@213115|Desulfovibrionales 28221|Deltaproteobacteria S DNA circulation - - - - - - - - - - - - DNA_circ_N k59_58370_1 525904.Tter_2546 7.22e-23 99.8 COG0589@1|root,COG0589@2|Bacteria,2NRGN@2323|unclassified Bacteria 2|Bacteria T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_162085_1 1265505.ATUG01000002_gene1353 6.49e-40 143.0 COG1024@1|root,COG1024@2|Bacteria,1N5AU@1224|Proteobacteria,42UMD@68525|delta/epsilon subdivisions,2WQDS@28221|Deltaproteobacteria,2MNJN@213118|Desulfobacterales 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_194454_1 998674.ATTE01000001_gene371 6.07e-105 337.0 COG4935@1|root,COG4935@2|Bacteria,1NJV7@1224|Proteobacteria,1RN7Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - Reprolysin_4 k59_194454_2 1049564.TevJSym_as00770 2.3e-42 143.0 2EPXR@1|root,33HI9@2|Bacteria,1NHEM@1224|Proteobacteria,1SGPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_194454_3 396588.Tgr7_0230 4.71e-37 134.0 COG0705@1|root,COG0705@2|Bacteria,1N8NS@1224|Proteobacteria,1SD4M@1236|Gammaproteobacteria,1X1C5@135613|Chromatiales 135613|Chromatiales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_194454_4 1249627.D779_0938 2.88e-107 317.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1WWEI@135613|Chromatiales 135613|Chromatiales H PFAM UBA THIF-type NAD FAD binding - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_194454_5 1049564.TevJSym_as00740 3.66e-58 183.0 2BG6F@1|root,32A39@2|Bacteria,1RI4Y@1224|Proteobacteria,1S5H3@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_194454_6 1279015.KB908457_gene2347 3.3e-82 256.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1Y3J6@135624|Aeromonadales 135624|Aeromonadales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_194454_7 1283300.ATXB01000001_gene591 1.95e-87 267.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1XEPW@135618|Methylococcales 135618|Methylococcales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_168558_1 754476.Q7A_414 2.88e-14 70.1 COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,1SH2G@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase - - - - - - - - - - - - PepSY k59_168558_2 1049564.TevJSym_ae00870 3.32e-55 180.0 COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria,1J75E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihaem cytochrome c - - - - - - - - - - - - DHC k59_181541_1 1089553.Tph_c18460 9.8e-41 139.0 COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,42G6R@68295|Thermoanaerobacterales 186801|Clostridia C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit hydC - 1.12.1.3,1.6.5.3 ko:K00334,ko:K18330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_181541_2 665956.HMPREF1032_01746 5.19e-20 87.4 COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,3WJHP@541000|Ruminococcaceae 186801|Clostridia C Ferredoxin - - 1.12.1.3 ko:K17992 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx k59_6521_1 1123073.KB899241_gene1926 1.05e-21 97.1 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria,1X4RA@135614|Xanthomonadales 135614|Xanthomonadales S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_175022_1 1049564.TevJSym_aq00120 1.96e-51 164.0 2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - MazG k59_175022_2 1049564.TevJSym_aq00110 8.79e-302 846.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1J4DP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_175022_3 342610.Patl_0009 5.37e-94 281.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,2PZDH@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J glycyl-tRNA synthetase, alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_123192_1 1278307.KB906973_gene1352 1.3e-73 241.0 COG3307@1|root,COG3307@2|Bacteria,1QR23@1224|Proteobacteria,1SMCP@1236|Gammaproteobacteria,2QHRI@267894|Psychromonadaceae 1236|Gammaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_200955_1 936136.ARRT01000005_gene199 7.12e-54 185.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_58389_1 469609.HMPREF0847_01566 1.39e-78 243.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,4HABJ@91061|Bacilli 91061|Bacilli E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_187998_1 96561.Dole_1481 2.16e-54 172.0 COG1433@1|root,COG1433@2|Bacteria,1MZ77@1224|Proteobacteria,42U3G@68525|delta/epsilon subdivisions,2WQ5N@28221|Deltaproteobacteria,2MKGB@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k59_90794_1 756499.Desde_2449 1.64e-07 57.8 COG2826@1|root,COG2826@2|Bacteria,1TRSF@1239|Firmicutes,248IJ@186801|Clostridia,262X4@186807|Peptococcaceae 186801|Clostridia L Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_162095_1 1049564.TevJSym_ac01030 2.91e-125 367.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9BP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_162095_2 1049564.TevJSym_ac01020 1.43e-154 451.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_142629_1 1049564.TevJSym_ab01930 4.04e-133 407.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1J4N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_45405_1 477974.Daud_1620 4.9e-28 108.0 COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,262VC@186807|Peptococcaceae 186801|Clostridia CO Redox-active disulfide protein - - - - - - - - - - - - Thioredoxin_3 k59_194462_2 1190603.AJYD01000097_gene2400 2.08e-105 316.0 28MAQ@1|root,2ZAPC@2|Bacteria,1PTEN@1224|Proteobacteria,1S3M7@1236|Gammaproteobacteria,1Y1CE@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_149126_1 631362.Thi970DRAFT_02969 6.22e-226 663.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1WXH7@135613|Chromatiales 135613|Chromatiales I SMART Phospholipid glycerol acyltransferase - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_123199_1 177437.HRM2_38930 2.78e-27 111.0 COG0784@1|root,COG2984@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Response_reg k59_123199_2 1265505.ATUG01000002_gene1272 4.44e-41 145.0 COG1600@1|root,COG1600@2|Bacteria,1RAYI@1224|Proteobacteria,42R4W@68525|delta/epsilon subdivisions,2WK0B@28221|Deltaproteobacteria,2MJVT@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - - - - - - - - - - - k59_181550_1 1049564.TevJSym_ao00740 1.44e-105 314.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1J4IH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell shape-determining protein mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963 - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_181550_2 314278.NB231_15868 2.61e-41 142.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_90805_1 1439940.BAY1663_02837 1.82e-71 228.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,1RSFD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein alpha chain nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_90805_2 870187.Thini_4010 7.53e-125 369.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,1RMV3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation nifK - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_200966_1 118161.KB235919_gene6402 2.6e-44 157.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_19500_1 933262.AXAM01000047_gene2344 9.84e-97 292.0 COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria,2MHKX@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_58404_1 395494.Galf_0781 4.18e-154 470.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,2WGI2@28216|Betaproteobacteria,44VD9@713636|Nitrosomonadales 28216|Betaproteobacteria EI Carbamoyl-phosphate synthetase large chain domain protein uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_49_1 96561.Dole_0298 4.19e-78 238.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2MIJ1@213118|Desulfobacterales 28221|Deltaproteobacteria KO TIGRFAM hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_97284_2 1123401.JHYQ01000003_gene2116 9.13e-50 172.0 COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF697) - - - - - - - - - - - - DUF697,MMR_HSR1 k59_149148_1 1049564.TevJSym_ak01000 2.31e-141 410.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_6537_2 1123228.AUIH01000091_gene569 4.37e-46 171.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_38937_1 1049564.TevJSym_aq00040 1.67e-84 260.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1J4NI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_188011_1 187272.Mlg_0847 6.01e-23 96.3 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales 135613|Chromatiales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_188011_2 351348.Maqu_0856 1.36e-37 127.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,467SE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_136157_1 1049564.TevJSym_ah00420 7.64e-82 249.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1J5F1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2564,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 PdxJ k59_162098_1 452637.Oter_3803 1.39e-127 377.0 COG0845@1|root,COG0845@2|Bacteria,46U1B@74201|Verrucomicrobia,3K78A@414999|Opitutae 414999|Opitutae M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_64893_1 1049564.TevJSym_ad00110 4.68e-122 357.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1J559@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSSON_1240.SSON_1444,iYL1228.KPN_02176 Phe_tRNA-synt_N,tRNA-synt_2d k59_19559_1 742741.HMPREF9475_02917 8.13e-21 92.4 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,221S4@1506553|Lachnoclostridium 186801|Clostridia G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_136198_1 1125863.JAFN01000001_gene2679 1.32e-49 164.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NZS@68525|delta/epsilon subdivisions,2WINI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_196870_1 933262.AXAM01000040_gene1230 1.02e-68 216.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MHWY@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535,ko:K13599 ko00540,ko01100,ko02020,map00540,map01100,map02020 M00060,M00498 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005,ko02022 - - - LpxC k59_87068_2 1056820.KB900643_gene824 6.2e-82 295.0 COG2885@1|root,COG4547@1|root,COG5384@1|root,COG2885@2|Bacteria,COG4547@2|Bacteria,COG5384@2|Bacteria,1MX1F@1224|Proteobacteria,1RYU1@1236|Gammaproteobacteria,2PNMF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria HJM Cadherin repeats. - - - - - - - - - - - - Cadherin_3,DUF4347,OmpA k59_87068_3 1049564.TevJSym_an00180 8.21e-184 518.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1J4QK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase pucG - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_203747_1 159087.Daro_4074 1.71e-63 195.0 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2VSQ1@28216|Betaproteobacteria,2KWPM@206389|Rhodocyclales 206389|Rhodocyclales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_151974_1 998088.B565_0539 5.78e-78 242.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1Y4SC@135624|Aeromonadales 135624|Aeromonadales P Zinc uptake ABC transporter, permease znuB - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_145591_1 1167006.UWK_01718 8.52e-40 140.0 COG1296@1|root,COG1296@2|Bacteria,1P6U3@1224|Proteobacteria,42QVQ@68525|delta/epsilon subdivisions,2WMW1@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM AzlC family protein - - - - - - - - - - - - AzlC k59_178051_1 861208.AGROH133_14339 2.72e-21 94.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4B9N5@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS,PAS_3,PAS_9 k59_178051_2 189753.AXAS01000010_gene7404 2.79e-63 202.0 COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3JQPG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_164777_1 1304284.L21TH_1784 4.65e-12 62.4 COG1918@1|root,COG1918@2|Bacteria,1UF53@1239|Firmicutes,24SUC@186801|Clostridia,36P9J@31979|Clostridiaceae 186801|Clostridia P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_164777_2 96561.Dole_0343 2.12e-24 94.0 COG1918@1|root,COG1918@2|Bacteria,1N8ZJ@1224|Proteobacteria,43AAA@68525|delta/epsilon subdivisions,2WT3F@28221|Deltaproteobacteria,2MM74@213118|Desulfobacterales 28221|Deltaproteobacteria P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_164777_3 1121439.dsat_1977 2.15e-26 108.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2M83R@213115|Desulfovibrionales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_138665_1 768671.ThimaDRAFT_3100 2.69e-77 238.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1RMKG@1236|Gammaproteobacteria,1X24U@135613|Chromatiales 135613|Chromatiales G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_138665_2 768671.ThimaDRAFT_3099 2.61e-95 286.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1RYI1@1236|Gammaproteobacteria,1X255@135613|Chromatiales 135613|Chromatiales G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_48412_1 698758.AXY_00450 2.01e-73 230.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H9NW@91061|Bacilli 91061|Bacilli L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_28903_1 335543.Sfum_2347 2.77e-08 54.3 COG0438@1|root,COG0438@2|Bacteria,1RA8H@1224|Proteobacteria,42RMM@68525|delta/epsilon subdivisions,2WNQY@28221|Deltaproteobacteria,2MQWR@213462|Syntrophobacterales 28221|Deltaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_28903_2 56780.SYN_02626 6.74e-100 302.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_197085_2 379066.GAU_3829 1.32e-10 60.1 2AGHX@1|root,316QI@2|Bacteria,1ZUUG@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_81031_1 795359.TOPB45_0410 6.64e-36 129.0 COG0802@1|root,COG0802@2|Bacteria,2GHFI@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_81031_2 933262.AXAM01000002_gene503 2.34e-45 161.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales 28221|Deltaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_113209_2 156578.ATW7_03392 1.26e-37 145.0 COG2199@1|root,COG3706@2|Bacteria,1QWCN@1224|Proteobacteria,1T2TW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T a CheY-like receiver domain and a - - - - - - - - - - - - Response_reg k59_9619_1 153721.MYP_4724 2.82e-47 162.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,47Q96@768503|Cytophagia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_178245_1 1265505.ATUG01000002_gene2768 6.81e-42 158.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,2MI31@213118|Desulfobacterales 28221|Deltaproteobacteria M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iAF987.Gmet_2474 OstA,OstA_2,OstA_C k59_184891_1 566466.NOR53_2715 2.13e-61 202.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,1T2D1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0025 NhaP-type Na H and K H antiporters - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_171706_1 1265505.ATUG01000002_gene1096 1.75e-60 204.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MPY1@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_22653_1 1318628.MARLIPOL_01570 1.26e-35 123.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,467YW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_22653_2 754476.Q7A_2836 1.25e-94 286.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_191142_1 909663.KI867150_gene2086 1.79e-23 108.0 COG3605@1|root,COG3605@2|Bacteria 2|Bacteria T phosphoenolpyruvate-protein phosphotransferase activity - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - GAF_2,GGDEF,HTH_30 k59_120158_1 335543.Sfum_2163 5.59e-111 328.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2MQWK@213462|Syntrophobacterales 28221|Deltaproteobacteria T PhoH-like protein phoH2 - - ko:K06217 - - - - ko00000 - - - PhoH k59_184893_1 1123368.AUIS01000003_gene1680 3.55e-35 128.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,2NBYJ@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_184893_2 641107.CDLVIII_1881 2.1e-23 94.7 COG1898@1|root,COG1898@2|Bacteria,1TRVB@1239|Firmicutes,248VX@186801|Clostridia,36DWD@31979|Clostridiaceae 186801|Clostridia M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS02630,iHN637.CLJU_RS02745 dTDP_sugar_isom k59_164962_1 177437.HRM2_39480 3.66e-17 88.2 COG3385@1|root,COG3385@2|Bacteria,1RM2A@1224|Proteobacteria,42WE3@68525|delta/epsilon subdivisions,2X6QW@28221|Deltaproteobacteria,2MN97@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_126754_1 1121441.AUCX01000014_gene561 7.84e-35 133.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42NTQ@68525|delta/epsilon subdivisions,2WITY@28221|Deltaproteobacteria,2M8YW@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_126754_2 1232410.KI421421_gene3825 1.64e-20 91.3 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_73974_1 1049564.TevJSym_ad01700 1.22e-81 246.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1J5R7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB k59_73974_2 1049564.TevJSym_ad01710 1.7e-116 335.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1J6FA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_9630_1 95619.PM1_0205600 3.28e-15 74.7 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_9630_2 396588.Tgr7_3208 1.67e-35 132.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales 135613|Chromatiales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_48426_1 1232437.KL662020_gene705 3.31e-79 250.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_99903_1 1123371.ATXH01000005_gene2134 4.96e-34 130.0 COG1566@1|root,COG1566@2|Bacteria,2GH9M@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria V HlyD membrane-fusion protein of T1SS - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_D23 k59_138850_4 314287.GB2207_07257 8.75e-66 206.0 COG1670@1|root,COG1670@2|Bacteria,1RGKF@1224|Proteobacteria,1S28M@1236|Gammaproteobacteria,1JAAP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Acetyltransferase (GNAT) domain rimL GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017198,GO:0018193,GO:0018209,GO:0019538,GO:0030920,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1990189 - ko:K03817 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_158634_1 933262.AXAM01000073_gene3364 5.34e-85 255.0 COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MI50@213118|Desulfobacterales 28221|Deltaproteobacteria F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_158634_2 187272.Mlg_1363 3.91e-08 54.7 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1WXKW@135613|Chromatiales 135613|Chromatiales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_191147_2 859657.RPSI07_2279 2.65e-81 257.0 COG1413@1|root,COG1413@2|Bacteria,1NUN2@1224|Proteobacteria,2VMQF@28216|Betaproteobacteria,1KB9X@119060|Burkholderiaceae 28216|Betaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2 k59_48431_1 1304885.AUEY01000011_gene1750 5.53e-58 202.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MHQJ@213118|Desulfobacterales 28221|Deltaproteobacteria OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_42481_1 1121405.dsmv_1954 4.56e-121 352.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2MJ2R@213118|Desulfobacterales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1,1.2.7.7 ko:K00170,ko:K00187 ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R07160,R08034,R08566,R08567 RC00004,RC00250,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_9636_1 617140.AJZE01000078_gene1847 2.1e-144 427.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_145785_1 1232410.KI421419_gene2478 2.35e-119 360.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,43RYP@69541|Desulfuromonadales 28221|Deltaproteobacteria C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2763 Aconitase,Aconitase_C k59_81043_2 94122.Shewana3_0168 9.38e-121 415.0 COG2931@1|root,COG3637@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3637@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2QA62@267890|Shewanellaceae 1236|Gammaproteobacteria MQ Dystroglycan-type cadherin domain protein - - - ko:K11005 - - - - ko00000,ko02000,ko02042 1.C.11 - - Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,VWA_2 k59_94351_1 1049564.TevJSym_bd00140 6.74e-197 582.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_54642_1 1121445.ATUZ01000013_gene1008 1.36e-45 154.0 COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,42S3C@68525|delta/epsilon subdivisions,2WNV0@28221|Deltaproteobacteria,2MBI2@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM isochorismatase hydrolase yddQ - - - - - - - - - - - Isochorismatase k59_126776_1 56780.SYN_00982 4.57e-91 285.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,2MQW8@213462|Syntrophobacterales 28221|Deltaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_106745_2 1056820.KB900638_gene66 3e-34 130.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_178249_1 1049564.TevJSym_an00080 1.52e-126 381.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_178249_3 857087.Metme_2403 5.58e-51 193.0 COG0642@1|root,COG0784@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_113230_1 1123228.AUIH01000026_gene3924 7.33e-12 73.2 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,1XMTD@135619|Oceanospirillales 135619|Oceanospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_113230_2 1049564.TevJSym_al00130 1.06e-65 208.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1J5QD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation ydiA GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_87297_1 1049564.TevJSym_at00030 8.03e-101 301.0 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_158647_1 1144305.PMI02_05061 2.24e-51 164.0 COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,2U9T4@28211|Alphaproteobacteria,2K6BF@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the urease beta subunit family ureB - 3.5.1.5 ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta k59_158647_2 1121403.AUCV01000019_gene3263 4.94e-122 364.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,42NUG@68525|delta/epsilon subdivisions,2WJM4@28221|Deltaproteobacteria,2MMK6@213118|Desulfobacterales 28221|Deltaproteobacteria E Urease alpha-subunit, N-terminal domain ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_48441_1 533240.CRC_01600 7.06e-41 148.0 COG0714@1|root,COG0714@2|Bacteria,1G09T@1117|Cyanobacteria,1HMFT@1161|Nostocales 1117|Cyanobacteria S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,AAA_5 k59_184904_1 1049564.TevJSym_av00360 3.06e-138 413.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4UY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU general secretion pathway protein D xcsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_184904_2 1049564.TevJSym_av00370 1.65e-166 480.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J57C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_99915_1 1049564.TevJSym_ag00990 9.31e-197 555.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1J4GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_132964_1 765912.Thimo_0851 1.79e-59 195.0 COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1WX0X@135613|Chromatiales 135613|Chromatiales Q Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family tpm - 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT k59_132964_2 435908.IDSA_11125 3.9e-38 135.0 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria,2QEY8@267893|Idiomarinaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_81327_1 439235.Dalk_5159 4.17e-63 205.0 COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,2MHU7@213118|Desulfobacterales 28221|Deltaproteobacteria G aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_81327_2 1121405.dsmv_0440 2.27e-22 89.4 2E9C8@1|root,333JY@2|Bacteria,1PAR4@1224|Proteobacteria,432FD@68525|delta/epsilon subdivisions,2WY2S@28221|Deltaproteobacteria,2MP8E@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_62616_2 1123518.ARWI01000001_gene1501 2.29e-43 142.0 COG0636@1|root,COG0636@2|Bacteria,1R359@1224|Proteobacteria,1T63K@1236|Gammaproteobacteria,461DV@72273|Thiotrichales 72273|Thiotrichales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_29795_2 1123399.AQVE01000002_gene2333 1.03e-50 165.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,460NZ@72273|Thiotrichales 72273|Thiotrichales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_55310_1 56780.SYN_03249 1.47e-135 397.0 COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,42TEG@68525|delta/epsilon subdivisions,2WPXW@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_74826_1 1049564.TevJSym_aj00810 2.74e-153 457.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1J907@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain ttrA - 1.8.5.5,1.8.5.6 ko:K08352,ko:K08357,ko:K21307 ko00920,ko01100,ko01120,ko02020,map00920,map01100,map01120,map02020 - R10149,R10150,R11487 RC00168,RC02823,RC03109 ko00000,ko00001,ko01000,ko02000 5.A.3.10,5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_197931_1 768710.DesyoDRAFT_3008 0.000221 44.3 COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,2612H@186807|Peptococcaceae 186801|Clostridia H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_197931_2 335543.Sfum_4045 1.6e-63 194.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,42SN5@68525|delta/epsilon subdivisions,2WP28@28221|Deltaproteobacteria,2MS1Y@213462|Syntrophobacterales 28221|Deltaproteobacteria C DsrC like protein dsrC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_23574_1 998674.ATTE01000001_gene3511 2.8e-67 214.0 COG1737@1|root,COG1737@2|Bacteria,1N3YS@1224|Proteobacteria,1S32Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_6,SIS k59_23574_2 1198232.CYCME_2313 3.56e-34 121.0 2CEN3@1|root,2ZX63@2|Bacteria,1P720@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 k59_23574_3 208439.AJAP_29220 1.06e-23 107.0 COG0596@1|root,COG0596@2|Bacteria,2GMYM@201174|Actinobacteria,4E938@85010|Pseudonocardiales 201174|Actinobacteria S TAP-like protein - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_191941_1 335543.Sfum_4053 9.23e-108 322.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MQ46@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_121230_2 870187.Thini_4450 9.24e-69 224.0 COG3220@1|root,COG3220@2|Bacteria,1R9AA@1224|Proteobacteria,1S3KZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_36625_1 1121403.AUCV01000016_gene4398 3.17e-86 275.0 COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,42SXG@68525|delta/epsilon subdivisions,2WP6Y@28221|Deltaproteobacteria,2MNMK@213118|Desulfobacterales 28221|Deltaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C,PAP2,SNARE_assoc k59_49369_1 1125863.JAFN01000001_gene224 3.06e-102 320.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2WJJV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_185933_1 1121405.dsmv_0654 1.51e-18 91.3 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,42P8Y@68525|delta/epsilon subdivisions,2WJYW@28221|Deltaproteobacteria,2MIZ7@213118|Desulfobacterales 28221|Deltaproteobacteria P Von Willebrand factor type A - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA k59_127861_1 1249627.D779_0545 3.83e-82 263.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RPVU@1236|Gammaproteobacteria,1WX41@135613|Chromatiales 135613|Chromatiales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_74834_1 748658.KB907316_gene580 4.67e-96 298.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1WW0Q@135613|Chromatiales 135613|Chromatiales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_88146_2 1249627.D779_3953 3.77e-81 253.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1WVWE@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_185939_2 96561.Dole_2854 2.43e-52 174.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,42M1U@68525|delta/epsilon subdivisions,2WKK5@28221|Deltaproteobacteria,2MINI@213118|Desulfobacterales 28221|Deltaproteobacteria G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_172340_1 765912.Thimo_2579 9.29e-30 117.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_172340_2 1049564.TevJSym_am00840 1.61e-27 101.0 2E3CN@1|root,32YBX@2|Bacteria,1N716@1224|Proteobacteria,1SEFN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_172340_3 910964.GEAM_1102 4.46e-71 220.0 COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S42B@1236|Gammaproteobacteria 1236|Gammaproteobacteria J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_172340_4 760192.Halhy_0471 5.19e-37 132.0 COG2159@1|root,COG2159@2|Bacteria,4NJP9@976|Bacteroidetes 976|Bacteroidetes S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_23584_1 1249627.D779_3420 1.46e-86 264.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria,1WX99@135613|Chromatiales 135613|Chromatiales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_23584_2 1249627.D779_3421 2.9e-93 288.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,1RQXD@1236|Gammaproteobacteria,1WVWT@135613|Chromatiales 135613|Chromatiales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K11960 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2,HEAT_2 k59_10599_1 1232410.KI421412_gene412 3.7e-52 174.0 COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43SCE@69541|Desulfuromonadales 28221|Deltaproteobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_165778_4 1117314.PCIT_19724 3.68e-277 791.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,2Q1W3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_69013_1 1049564.TevJSym_ao00450 6.25e-72 226.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1J4ZK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_55323_1 1049564.TevJSym_ad00680 6.25e-168 490.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria,1J5K4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_95535_1 673860.AciM339_0075 9.63e-08 49.7 COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,3F2TZ@33867|unclassified Euryarchaeota 28890|Euryarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoK - 2.7.7.6 ko:K03055 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb6 k59_10603_1 1125863.JAFN01000001_gene1981 3.52e-51 174.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_10603_2 1121918.ARWE01000001_gene974 6.01e-31 117.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,43BDC@68525|delta/epsilon subdivisions,2WK43@28221|Deltaproteobacteria 28221|Deltaproteobacteria ET Bacterial periplasmic substrate-binding proteins aapJ - - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_185949_2 1499683.CCFF01000016_gene811 1.62e-19 91.3 COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae 186801|Clostridia P Belongs to the sulfur carrier protein TusA family cdr - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k59_152951_1 1121403.AUCV01000034_gene3830 3.03e-22 99.4 COG0265@1|root,COG0265@2|Bacteria,1RINT@1224|Proteobacteria,42UDP@68525|delta/epsilon subdivisions,2WQQ6@28221|Deltaproteobacteria,2MNK8@213118|Desulfobacterales 28221|Deltaproteobacteria O Trypsin - - - - - - - - - - - - Trypsin_2 k59_43802_1 641107.CDLVIII_5310 6.35e-66 224.0 COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,24979@186801|Clostridia 186801|Clostridia S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_191946_2 1348114.OM33_21380 1.52e-32 117.0 2E98M@1|root,333H0@2|Bacteria,1N9JN@1224|Proteobacteria,1SQZT@1236|Gammaproteobacteria,2Q4SE@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_191946_3 1304883.KI912532_gene2145 3.92e-24 94.0 COG0440@1|root,COG0440@2|Bacteria,1N065@1224|Proteobacteria,2VV2S@28216|Betaproteobacteria,2KWWN@206389|Rhodocyclales 206389|Rhodocyclales E Acetolactate synthase small ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5 k59_191946_4 882.DVU_0360 2.05e-234 665.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42MV2@68525|delta/epsilon subdivisions,2WJ7U@28221|Deltaproteobacteria,2M839@213115|Desulfovibrionales 28221|Deltaproteobacteria H TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_29812_1 1440053.JOEI01000009_gene6037 2.41e-57 193.0 COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria 201174|Actinobacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase k59_204784_2 713586.KB900536_gene1196 5.57e-126 375.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1WXXP@135613|Chromatiales 135613|Chromatiales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_204784_3 768671.ThimaDRAFT_4091 6.38e-88 265.0 COG2009@1|root,COG2009@2|Bacteria,1R7RY@1224|Proteobacteria,1RSM4@1236|Gammaproteobacteria,1WWTS@135613|Chromatiales 135613|Chromatiales C succinate dehydrogenase - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_204784_4 765913.ThidrDRAFT_0493 2.22e-102 315.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RQXS@1236|Gammaproteobacteria,1WWR7@135613|Chromatiales 135613|Chromatiales C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_139724_2 1232437.KL662026_gene983 9.2e-12 61.2 2CFUP@1|root,33M5R@2|Bacteria,1NJ3N@1224|Proteobacteria,42XXS@68525|delta/epsilon subdivisions,2WTFC@28221|Deltaproteobacteria,2MMAK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_81897_1 1049564.TevJSym_aa02180 4.52e-80 241.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1J5XT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_36652_2 694429.Pyrfu_1439 2.32e-08 56.2 COG2524@1|root,arCOG00610@2157|Archaea,2XPSP@28889|Crenarchaeota 28889|Crenarchaeota K signal transduction protein with CBS domains - - - ko:K07744 - - - - ko00000 - - - CBS,HrcA_DNA-bdg k59_185955_1 795666.MW7_0983 2.87e-29 122.0 COG5283@1|root,COG5283@2|Bacteria,1R5FU@1224|Proteobacteria,2VPNW@28216|Betaproteobacteria 28216|Betaproteobacteria NU Phage-related minor tail protein - - - - - - - - - - - - - k59_146628_1 1122599.AUGR01000022_gene1657 1.03e-53 174.0 COG4665@1|root,COG4665@2|Bacteria,1RDYM@1224|Proteobacteria,1S58A@1236|Gammaproteobacteria,1XKUX@135619|Oceanospirillales 135619|Oceanospirillales Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_146628_2 998674.ATTE01000001_gene3514 2.51e-201 568.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,460BC@72273|Thiotrichales 72273|Thiotrichales Q transporter, dctM subunit - - - - - - - - - - - - DctM k59_16419_1 56780.SYN_00295 1.47e-86 286.0 COG0366@1|root,COG3408@1|root,COG0366@2|Bacteria,COG3408@2|Bacteria,1MWBZ@1224|Proteobacteria,43AE9@68525|delta/epsilon subdivisions,2X5U3@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Alpha amylase catalytic - - - - - - - - - - - - Alpha-amylase,GDE_C,GDE_N k59_146834_1 525897.Dbac_0332 1.77e-55 194.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,2M98V@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM MscS Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_16614_1 335543.Sfum_0008 1.38e-96 310.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MRBU@213462|Syntrophobacterales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_121537_1 765912.Thimo_0587 3e-92 278.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_121537_2 977880.RALTA_A1035 7.24e-100 290.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,1K10B@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_75092_1 1238182.C882_4103 1.19e-58 200.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2JPBE@204441|Rhodospirillales 204441|Rhodospirillales I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_75092_2 1238182.C882_4102 3.38e-17 79.7 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQCM@204441|Rhodospirillales 204441|Rhodospirillales I Belongs to the thiolase family - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_36868_1 768671.ThimaDRAFT_2890 4.54e-88 280.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_69257_1 335543.Sfum_1580 4.25e-71 216.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2MQGH@213462|Syntrophobacterales 28221|Deltaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_49572_1 1192034.CAP_5001 7.47e-20 97.1 2DBVB@1|root,2ZBAB@2|Bacteria,1R9T2@1224|Proteobacteria,43DGS@68525|delta/epsilon subdivisions,2X8NM@28221|Deltaproteobacteria,2Z2D4@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF3396) - - - - - - - - - - - - DUF3396 k59_49572_2 1006004.GBAG_0909 1e-60 216.0 COG0596@1|root,COG1196@1|root,COG0596@2|Bacteria,COG1196@2|Bacteria,1MY2P@1224|Proteobacteria,1RQQM@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - Abhydrolase_8,DUF3274,DUF4150 k59_49572_3 626418.bglu_1g23310 3.97e-21 93.2 COG0304@1|root,COG0304@2|Bacteria 2|Bacteria I 3-oxoacyl-[acyl-carrier-protein] synthase activity - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ketoacyl-synt k59_186200_1 1122149.BACN01000104_gene2008 0.000807 44.3 COG3293@1|root,COG3293@2|Bacteria,1U5ZT@1239|Firmicutes,4IFNT@91061|Bacilli,3F6RW@33958|Lactobacillaceae 91061|Bacilli L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DUF4096 k59_146836_1 264201.pc0884 8.58e-64 206.0 COG0082@1|root,COG0082@2|Bacteria,2JFU7@204428|Chlamydiae 204428|Chlamydiae E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_100997_1 207954.MED92_10084 4.38e-225 654.0 COG4694@1|root,COG4694@2|Bacteria,1PRHR@1224|Proteobacteria,1RWYP@1236|Gammaproteobacteria,1XQCB@135619|Oceanospirillales 135619|Oceanospirillales S AAA domain - - - - - - - - - - - - AAA_13 k59_100997_2 879212.DespoDRAFT_00374 1.18e-264 729.0 COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,42PFX@68525|delta/epsilon subdivisions,2WJS3@28221|Deltaproteobacteria,2MHR3@213118|Desulfobacterales 28221|Deltaproteobacteria L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C k59_100997_3 335283.Neut_2425 0.0 1636.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,2VKQ5@28216|Betaproteobacteria,371RS@32003|Nitrosomonadales 28216|Betaproteobacteria L Putative exonuclease SbcCD, C subunit sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C k59_100997_6 323850.Shew_0989 6.37e-28 110.0 COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria 1224|Proteobacteria L Conjugal transfer protein traA - - - - - - - - - - - AAA_30,MobA_MobL,TrwC k59_128138_1 1049564.TevJSym_aa01810 3.33e-246 693.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_128138_2 572477.Alvin_2539 2.33e-106 326.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_23841_1 1137799.GZ78_27900 1.54e-96 306.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria,1XHS7@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the ClpA ClpB family - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_16619_1 86416.Clopa_2892 2.41e-06 55.1 COG1589@1|root,COG1589@2|Bacteria,1VEMW@1239|Firmicutes,24QKM@186801|Clostridia,36GXB@31979|Clostridiaceae 186801|Clostridia D Essential cell division protein ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_55540_1 644282.Deba_2682 6.07e-37 130.0 COG0310@1|root,COG0310@2|Bacteria,1RJRC@1224|Proteobacteria,42QZ5@68525|delta/epsilon subdivisions,2WMQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM cobalamin (vitamin B12) biosynthesis CbiM - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_30057_2 631362.Thi970DRAFT_02209 1.88e-136 394.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales 135613|Chromatiales G PFAM Fructosamine - - - - - - - - - - - - Fructosamin_kin k59_10870_1 1121448.DGI_1559 6.02e-56 197.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2M88K@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_36871_1 1167006.UWK_01150 1.26e-95 299.0 COG2070@1|root,COG2070@2|Bacteria,1R8ZS@1224|Proteobacteria,42N1N@68525|delta/epsilon subdivisions,2WMIF@28221|Deltaproteobacteria,2MMMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_95829_1 1121097.JCM15093_14 1.23e-112 335.0 COG0436@1|root,COG0436@2|Bacteria,4NENS@976|Bacteroidetes,2FMU2@200643|Bacteroidia,4AKGF@815|Bacteroidaceae 976|Bacteroidetes E COG0436 Aspartate tyrosine aromatic aminotransferase aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_146839_1 1049564.TevJSym_ac00410 1.22e-198 559.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1J5G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpO - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_44095_1 1230343.CANP01000035_gene2592 5.4e-18 90.9 COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,1SNAF@1236|Gammaproteobacteria,1JE2M@118969|Legionellales 118969|Legionellales G Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - - k59_198179_1 933262.AXAM01000006_gene1837 7.4e-76 249.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2MPS7@213118|Desulfobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_62888_1 1265505.ATUG01000001_gene3565 6.49e-166 482.0 COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit - - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane k59_134002_1 2340.JV46_19080 0.0 1240.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1J8A6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_134002_2 2340.JV46_19090 1.19e-135 385.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RRAN@1236|Gammaproteobacteria,1J89Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain fdhB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_11,Fer4_4,Fer4_7 k59_17952_1 1041930.Mtc_0274 1.27e-72 232.0 COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota 28890|Euryarchaeota I Belongs to the HMG-CoA reductase family hmgA-1 - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_31334_1 1109445.AGSX01000050_gene2160 3.83e-13 70.9 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1Z11J@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_167421_1 765911.Thivi_1763 8.29e-44 153.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_167421_2 765912.Thimo_3031 3.88e-49 166.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_56675_1 1121430.JMLG01000004_gene880 1.86e-49 174.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia 186801|Clostridia I TIGRFAM Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_70862_2 1415778.JQMM01000001_gene288 5.64e-280 805.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J7PV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL,cNMP_binding k59_135303_1 398767.Glov_1019 1.31e-67 213.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2WK1K@28221|Deltaproteobacteria,43SU7@69541|Desulfuromonadales 28221|Deltaproteobacteria F TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0388 His_biosynth k59_135303_2 161156.JQKW01000012_gene66 4.36e-06 48.1 COG0824@1|root,COG0824@2|Bacteria,2GHY2@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_5110_2 56780.SYN_02963 2.69e-86 268.0 COG2309@1|root,COG2309@2|Bacteria,1MW2Y@1224|Proteobacteria,42P6P@68525|delta/epsilon subdivisions,2WJF8@28221|Deltaproteobacteria,2MQZ9@213462|Syntrophobacterales 28221|Deltaproteobacteria E Thermophilic metalloprotease (M29) - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 k59_173899_1 317619.ANKN01000225_gene906 3.69e-39 149.0 COG0642@1|root,COG0745@1|root,COG3221@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3221@2|Bacteria,1GQYF@1117|Cyanobacteria 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_18379_1 1049564.TevJSym_aq00800 5.25e-178 503.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1J53T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_64470_1 663278.Ethha_1523 1.29e-80 265.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3WGS6@541000|Ruminococcaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_206525_1 1049564.TevJSym_ak00890 4.11e-71 216.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1J5ZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_56991_1 713587.THITH_01080 1.71e-183 519.0 COG3177@1|root,COG3177@2|Bacteria,1NB0K@1224|Proteobacteria,1S0F4@1236|Gammaproteobacteria,1WZ0V@135613|Chromatiales 135613|Chromatiales S Fic/DOC family - - - - - - - - - - - - Fic k59_56991_2 765910.MARPU_09030 5.38e-93 277.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1WWMM@135613|Chromatiales 135613|Chromatiales S TIGRFAM channel protein, hemolysin III family - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_56991_3 1122236.KB905146_gene1896 8.28e-114 336.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2VMU5@28216|Betaproteobacteria,2KNMV@206350|Nitrosomonadales 206350|Nitrosomonadales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_56991_4 261292.Nit79A3_0026 0.0 3856.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,371PE@32003|Nitrosomonadales 28216|Betaproteobacteria G Glycosyl hydrolase 36 superfamily, catalytic domain - - - - - - - - - - - - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_56991_7 404589.Anae109_4033 9.19e-153 446.0 COG0025@1|root,COG0025@2|Bacteria 2|Bacteria P sodium:proton antiporter activity sod22 - - - - - - - - - - - Na_H_Exchanger k59_56991_10 631362.Thi970DRAFT_04763 1.46e-185 522.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RMF2@1236|Gammaproteobacteria,1X0ZR@135613|Chromatiales 135613|Chromatiales O HflC and HflK could regulate a protease - - - - - - - - - - - - Band_7 k59_56991_11 631362.Thi970DRAFT_04762 7.44e-152 437.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales 135613|Chromatiales O HflC and HflK could encode or regulate a protease - - - - - - - - - - - - Band_7 k59_56991_12 298653.Franean1_1404 5.11e-60 204.0 COG2801@1|root,COG2801@2|Bacteria,2GN25@201174|Actinobacteria 2|Bacteria L Integrase catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_32,rve_3 k59_135682_1 1125863.JAFN01000001_gene2679 1.86e-35 129.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NZS@68525|delta/epsilon subdivisions,2WINI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_167675_1 706587.Desti_5385 1.59e-44 164.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_154800_1 998674.ATTE01000001_gene239 6.49e-86 267.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,460KI@72273|Thiotrichales 72273|Thiotrichales P Biological Process cation transport (GO 0006812), Molecular Function solute hydrogen antiporter activity (GO 0015299), Cellular Component integral to membrane (GO 0016021), Biological Process transmembrane transport (GO 0055085) - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_206529_1 1121403.AUCV01000024_gene3424 4.26e-54 183.0 COG3875@1|root,COG3875@2|Bacteria,1RHU4@1224|Proteobacteria,42SM9@68525|delta/epsilon subdivisions,2WPUJ@28221|Deltaproteobacteria,2MKWW@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 k59_18385_1 309803.CTN_1455 2.71e-37 127.0 COG3450@1|root,COG3450@2|Bacteria,2GDFM@200918|Thermotogae 200918|Thermotogae S Enzyme of the cupin superfamily - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_187951_1 1108045.GORHZ_077_00020 1.01e-11 67.0 COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4GBIG@85026|Gordoniaceae 201174|Actinobacteria H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_167680_1 289376.THEYE_A0758 8.32e-75 244.0 COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae 40117|Nitrospirae O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,Lon_C,Response_reg k59_148518_1 1049564.TevJSym_an00340 4.83e-60 187.0 2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_148518_2 1049564.TevJSym_an00330 1.45e-53 172.0 2AAM4@1|root,30ZYM@2|Bacteria,1RFTG@1224|Proteobacteria,1S4UQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF2384 k59_148518_3 765910.MARPU_01155 9.48e-89 272.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1WXBJ@135613|Chromatiales 135613|Chromatiales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_102658_1 338963.Pcar_1385 4.3e-76 237.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_187952_1 1265505.ATUG01000002_gene2146 1.54e-168 485.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MB6@68525|delta/epsilon subdivisions,2WJMI@28221|Deltaproteobacteria,2MIMT@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acetyl-CoA hydrolase transferase ato-2 - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - iAF987.Gmet_1125 AcetylCoA_hyd_C,AcetylCoA_hydro k59_64483_1 1123508.JH636442_gene4266 4.04e-17 77.8 COG2128@1|root,COG2128@2|Bacteria,2IZDY@203682|Planctomycetes 203682|Planctomycetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_167688_1 338963.Pcar_1514 2.12e-51 176.0 COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,42NCT@68525|delta/epsilon subdivisions,2WKEG@28221|Deltaproteobacteria,43SUK@69541|Desulfuromonadales 28221|Deltaproteobacteria G Proposed homoserine kinase apgM - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_76787_1 795666.MW7_0977 0.0 1069.0 COG4733@1|root,COG4733@2|Bacteria,1MXB4@1224|Proteobacteria,2VJS7@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_76787_2 522373.Smlt1855 4.01e-26 97.8 2EK40@1|root,33DUE@2|Bacteria,1NJE0@1224|Proteobacteria,1SUTD@1236|Gammaproteobacteria,1X8XT@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_83673_1 1189620.AJXL01000217_gene3135 4.1e-06 57.4 COG3385@1|root,COG3385@2|Bacteria,4NIN4@976|Bacteroidetes,1IIBH@117743|Flavobacteriia 976|Bacteroidetes L Domain of unknown function (DUF4372) - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_18389_2 243233.MCA0929.1 2.51e-11 59.7 2CJ5C@1|root,32S99@2|Bacteria,1N1AR@1224|Proteobacteria,1SFAB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S crispr-associated protein - - - ko:K09951 - - - - ko00000,ko02048 - - - Cas_Cas2CT1978 k59_148521_1 96561.Dole_1172 2.04e-25 100.0 2DMM6@1|root,32SCC@2|Bacteria,1N68R@1224|Proteobacteria,42UEF@68525|delta/epsilon subdivisions,2WQ5H@28221|Deltaproteobacteria,2MKQI@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_148521_2 857087.Metme_0082 1.02e-11 65.9 COG0454@1|root,COG0456@2|Bacteria,1QZJR@1224|Proteobacteria,1S8SA@1236|Gammaproteobacteria,1XGZ5@135618|Methylococcales 135618|Methylococcales H PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - - k59_76788_1 1121396.KB893012_gene4012 1.13e-111 345.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2MHN2@213118|Desulfobacterales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_161569_1 1122201.AUAZ01000004_gene3441 2.56e-64 201.0 28HUJ@1|root,2Z819@2|Bacteria,1MW8B@1224|Proteobacteria,1S2QX@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_109789_1 933262.AXAM01000029_gene2753 2.98e-94 289.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MHS6@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_102667_1 1001585.MDS_2815 1.71e-129 383.0 COG3385@1|root,COG3385@2|Bacteria,1PQZT@1224|Proteobacteria,1TBQQ@1236|Gammaproteobacteria,1YIJZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_167699_1 1395571.TMS3_0118785 9.79e-42 149.0 28IJW@1|root,2Z8KR@2|Bacteria,1R45I@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_206552_1 1266914.ATUK01000010_gene1319 2.65e-118 357.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_161582_1 177437.HRM2_10540 3.57e-52 174.0 COG1102@1|root,COG1102@2|Bacteria,1R9XZ@1224|Proteobacteria,42R78@68525|delta/epsilon subdivisions,2WN7X@28221|Deltaproteobacteria,2MJR4@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_102672_1 1232410.KI421422_gene2071 2.61e-71 238.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,43S73@69541|Desulfuromonadales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_64501_1 887062.HGR_04838 1.43e-76 251.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,4AAN3@80864|Comamonadaceae 28216|Betaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_64501_2 2340.JV46_15280 1.67e-25 98.2 2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_64501_3 237368.SCABRO_03072 3.26e-59 190.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase cmoA GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 2.8.1.10 ko:K03149,ko:K15256 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000,ko03016 - - - Methyltransf_25,Methyltransf_31 k59_64503_1 880073.Calab_0683 1.09e-44 165.0 COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - Big_5,CarboxypepD_reg,DUF11,LRR_5,Peptidase_S8,SLH k59_90103_1 330214.NIDE2553 3.35e-58 194.0 COG2870@1|root,COG2870@2|Bacteria,3J0GT@40117|Nitrospirae 40117|Nitrospirae M Phosphomethylpyrimidine kinase - - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - PfkB k59_12564_1 909663.KI867150_gene2871 1.98e-68 223.0 COG3039@1|root,COG3039@2|Bacteria,1QY2X@1224|Proteobacteria 1224|Proteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6 k59_109795_1 985054.JQEZ01000009_gene3038 8.71e-101 332.0 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,4NCQD@97050|Ruegeria 28211|Alphaproteobacteria O Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_90109_1 643562.Daes_0245 4.07e-98 297.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,2M90B@213115|Desulfovibrionales 28221|Deltaproteobacteria BQ PFAM histone deacetylase superfamily - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_173925_1 706587.Desti_3053 6.06e-111 350.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_25625_1 1049564.TevJSym_ax00420 2.17e-97 298.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1J53S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_154816_2 448385.sce0655 2.16e-06 55.8 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales 28221|Deltaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,TPR_12 k59_135710_1 880072.Desac_1856 2.1e-63 208.0 COG0476@1|root,COG0476@2|Bacteria 2|Bacteria H Involved in molybdopterin and thiamine biosynthesis, family 2 - - - - - - - - - - - - ThiF k59_64516_1 237368.SCABRO_03668 2.61e-54 193.0 COG5421@1|root,COG5421@2|Bacteria,2J33B@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_77284_1 1089553.Tph_c14870 1.22e-46 160.0 COG3383@1|root,COG3383@2|Bacteria,1V1Y2@1239|Firmicutes,24FSX@186801|Clostridia,42I7W@68295|Thermoanaerobacterales 186801|Clostridia C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - 1.17.1.9,1.6.5.3 ko:K00123,ko:K00336 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_21,NADH-G_4Fe-4S_3 k59_77284_2 1121405.dsmv_1967 5.69e-164 478.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MMTC@213118|Desulfobacterales 28221|Deltaproteobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.12.1.3,1.6.5.3 ko:K00124,ko:K00335,ko:K05587,ko:K18331 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_142367_1 1121405.dsmv_2571 4.51e-60 196.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales 28221|Deltaproteobacteria E aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_142367_2 879212.DespoDRAFT_00691 2.08e-17 79.7 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MHVV@213118|Desulfobacterales 28221|Deltaproteobacteria E ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_168153_1 1121405.dsmv_1111 4.23e-25 101.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria,2MIWF@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM branched-chain amino acid aminotransferase ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_2853 Aminotran_4 k59_93329_4 1387312.BAUS01000004_gene1744 7.47e-69 218.0 COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2VRAJ@28216|Betaproteobacteria,2KNTK@206350|Nitrosomonadales 206350|Nitrosomonadales K Putative FMN-binding domain - - - ko:K07734 - - - - ko00000,ko03000 - - - FMN_bind_2 k59_93329_5 1121015.N789_10750 4.89e-47 155.0 COG3631@1|root,COG3631@2|Bacteria,1NAUM@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_93329_6 1026882.MAMP_02040 4.75e-65 207.0 COG0500@1|root,COG2226@2|Bacteria,1RF5Y@1224|Proteobacteria,1S57V@1236|Gammaproteobacteria,462C2@72273|Thiotrichales 72273|Thiotrichales Q methyltransferase - - - - - - - - - - - - - k59_203229_1 1131814.JAFO01000001_gene2089 2.42e-69 223.0 28HS3@1|root,2Z7ZE@2|Bacteria,1QH9A@1224|Proteobacteria,2TVB0@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_86557_1 671143.DAMO_2754 2.95e-10 65.1 COG1579@1|root,COG1579@2|Bacteria,2NPW0@2323|unclassified Bacteria 2|Bacteria S C4-type zinc ribbon domain CP_0228 - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 k59_53924_1 1049564.TevJSym_aa01930 1.58e-228 670.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_21967_1 1121405.dsmv_1757 5.22e-85 258.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2WK2V@28221|Deltaproteobacteria,2MI0R@213118|Desulfobacterales 28221|Deltaproteobacteria H PFAM Phosphomethylpyrimidine kinase thiD - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00941,ko:K14153,ko:K21219 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2909 Phos_pyr_kin,TMP-TENI,ThiP_synth k59_1937_2 314345.SPV1_06814 8.12e-15 74.7 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria 1224|Proteobacteria L Helicase - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SWIM k59_34817_1 1049564.TevJSym_ar00430 2.16e-83 273.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4MB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_132191_1 1162668.LFE_0927 9.67e-07 55.8 COG1538@1|root,COG1538@2|Bacteria,3J12K@40117|Nitrospirae 40117|Nitrospirae MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_47586_1 172045.KS04_07605 4.42e-27 114.0 COG1418@1|root,COG1418@2|Bacteria,4NFAG@976|Bacteroidetes,1HWWN@117743|Flavobacteriia,34PWJ@308865|Elizabethkingia 976|Bacteroidetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_93334_1 1502724.FF80_03107 3.2e-120 357.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_112493_1 257310.BB1322 2.53e-144 423.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,3T26T@506|Alcaligenaceae 28216|Betaproteobacteria C formate dehydrogenase fdsB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S,SLBB k59_60661_2 1121440.AUMA01000007_gene1260 3.77e-31 120.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WNUY@28221|Deltaproteobacteria,2M887@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_190344_1 156889.Mmc1_3185 6.51e-67 213.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2U7GG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator - - - ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_93335_1 1191523.MROS_2684 1.52e-47 167.0 COG3328@1|root,COG3328@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07497 - - - - ko00000 - - - Transposase_mut k59_196384_2 631362.Thi970DRAFT_02932 5.7e-131 391.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales 135613|Chromatiales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_93336_1 1121405.dsmv_3645 2.31e-65 225.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MI5C@213118|Desulfobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_34824_2 1342302.JASC01000003_gene3590 6.7e-05 47.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3ZVU6@60136|Sulfitobacter 28211|Alphaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_157839_1 1121439.dsat_0638 1.58e-111 327.0 COG0437@1|root,COG0437@2|Bacteria,1RCHX@1224|Proteobacteria,42S80@68525|delta/epsilon subdivisions,2X5D4@28221|Deltaproteobacteria,2MEPC@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding - - - - - - - - - - - - Fer4_11 k59_151517_1 1366050.N234_36435 2.49e-25 104.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_66998_1 1049564.TevJSym_at00760 1.02e-115 348.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1J5F2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_41519_1 1293054.HSACCH_00884 2.9e-26 105.0 COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,24AAC@186801|Clostridia,3WAFQ@53433|Halanaerobiales 186801|Clostridia BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_41519_2 1121405.dsmv_3532 6.38e-36 136.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42P6S@68525|delta/epsilon subdivisions,2WIWC@28221|Deltaproteobacteria,2MI1I@213118|Desulfobacterales 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_28226_1 1279017.AQYJ01000020_gene1347 2.91e-162 463.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,1RP49@1236|Gammaproteobacteria,4657W@72275|Alteromonadaceae 1236|Gammaproteobacteria E Saccharopine dehydrogenase HA62_29220 - 1.5.1.43,1.5.1.7 ko:K00290,ko:K13746 ko00300,ko00310,ko00330,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00330,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R09079,R09080 RC00053,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_184186_1 1116472.MGMO_134c00020 2.56e-65 208.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1XE8J@135618|Methylococcales 135618|Methylococcales K response regulator - - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_34830_1 768670.Calni_0806 2.17e-11 66.2 COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,2GEPU@200930|Deferribacteres 200930|Deferribacteres K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 k59_41523_1 1283300.ATXB01000001_gene946 6.13e-18 79.7 COG2913@1|root,COG2913@2|Bacteria,1QXS7@1224|Proteobacteria 1224|Proteobacteria J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_99227_1 357804.Ping_1164 3.49e-48 166.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L IS30 family ISPlu1B - - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_105899_1 998674.ATTE01000001_gene4168 2.37e-49 180.0 COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,1S2MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_28228_1 1121373.KB903665_gene3122 1.43e-05 51.6 COG3677@1|root,COG3677@2|Bacteria,4NJC5@976|Bacteroidetes 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_93347_1 925409.KI911562_gene2050 1.5e-11 68.9 COG3677@1|root,COG3677@2|Bacteria,4NJC5@976|Bacteroidetes,1IXDS@117747|Sphingobacteriia 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_145080_1 62928.azo2546 5.71e-115 344.0 COG0583@1|root,COG0583@2|Bacteria,1MXR1@1224|Proteobacteria,2VHKB@28216|Betaproteobacteria,2KWW3@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - ko:K19338 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_47610_1 304371.MCP_0919 1.23e-15 81.3 COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia 224756|Methanomicrobia S Predicted membrane protein (DUF2070) - - - ko:K08979 - - - - ko00000 - - - DUF2070 k59_164244_1 521011.Mpal_0018 1.84e-32 130.0 COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota 28890|Euryarchaeota L Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex rad50 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N k59_105901_1 765912.Thimo_3175 2.75e-97 290.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_14822_1 345219.Bcoa_1793 6.34e-08 57.8 COG3385@1|root,COG3385@2|Bacteria,1TPH7@1239|Firmicutes,4HB3I@91061|Bacilli,1ZE78@1386|Bacillus 91061|Bacilli L PFAM Transposase, IS4-like - - - - - - - - - - - - DDE_Tnp_1_4 k59_86755_3 883081.HMPREF9698_00875 8.68e-13 68.9 COG0584@1|root,COG0584@2|Bacteria,1TQ3Y@1239|Firmicutes,4HAI9@91061|Bacilli,27GBY@186828|Carnobacteriaceae 91061|Bacilli C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_196633_1 1233950.IW22_20200 5.94e-37 139.0 COG3385@1|root,COG3385@2|Bacteria,4P9J0@976|Bacteroidetes,1IM1V@117743|Flavobacteriia,3ZTV6@59732|Chryseobacterium 976|Bacteroidetes L transposase activity - - - - - - - - - - - - - k59_47863_1 1380391.JIAS01000013_gene3781 8.83e-83 278.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JUYT@204441|Rhodospirillales 204441|Rhodospirillales S Alpha-2-Macroglobulin - - - - - - - - - - - - A2M,A2M_N,A2M_N_2 k59_177734_1 713586.KB900536_gene631 1.3e-31 117.0 COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,1S7QS@1236|Gammaproteobacteria,1WYIE@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_177734_2 1173022.Cri9333_1181 4.76e-11 63.2 COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin k59_15061_1 63737.Npun_F1438 5.44e-38 141.0 COG1234@1|root,COG1234@2|Bacteria,1G1SW@1117|Cyanobacteria,1HTPW@1161|Nostocales 1117|Cyanobacteria L Helix-turn-helix of DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_4,HTH_Tnp_4 k59_73555_1 1167006.UWK_03272 1.99e-162 464.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MHTU@213118|Desulfobacterales 28221|Deltaproteobacteria E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_126008_1 945713.IALB_0228 7.8e-93 280.0 COG0113@1|root,COG0113@2|Bacteria 2|Bacteria H porphobilinogen synthase activity hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 ALAD k59_60920_2 673860.AciM339_1415 2.06e-72 240.0 COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,3F2ZT@33867|unclassified Euryarchaeota 28890|Euryarchaeota G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate apgM - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_60920_3 765913.ThidrDRAFT_2816 9.64e-87 278.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales 135613|Chromatiales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_158045_1 1049564.TevJSym_bp00060 1.19e-229 655.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_171306_1 768671.ThimaDRAFT_4175 8.71e-79 259.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_171306_2 1283300.ATXB01000001_gene1554 8.47e-58 185.0 COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,1S4E9@1236|Gammaproteobacteria,1XGES@135618|Methylococcales 135618|Methylococcales J ribosomal large subunit export from nucleus - - - - - - - - - - - - - k59_171306_4 456442.Mboo_0622 1.53e-19 93.6 COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia 224756|Methanomicrobia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis dbh - 2.7.7.7 ko:K04479 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_22209_1 765910.MARPU_08310 1.54e-184 531.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1WXBU@135613|Chromatiales 135613|Chromatiales P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_22209_2 765913.ThidrDRAFT_2893 1.74e-10 56.2 COG4890@1|root,COG4890@2|Bacteria,1PVJU@1224|Proteobacteria,1TK5Z@1236|Gammaproteobacteria,1WZP7@135613|Chromatiales 135613|Chromatiales S TIGRFAM Cyd operon protein YbgT - - 1.10.3.14 ko:K00424 ko00190,ko02020,map00190,map02020 M00153 - - ko00000,ko00001,ko01000 3.D.4.3 - - YbgT_YccB k59_22209_3 1121033.AUCF01000015_gene1492 1.39e-196 555.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,2JQ3X@204441|Rhodospirillales 204441|Rhodospirillales C oxidase, subunit cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_22209_4 1150469.RSPPHO_01253 7.58e-40 145.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2JPNF@204441|Rhodospirillales 204441|Rhodospirillales C oxidase, subunit cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_184412_1 1049564.TevJSym_aa00750 1.13e-89 275.0 COG1270@1|root,COG1270@2|Bacteria 2|Bacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_184412_3 472759.Nhal_3341 2.15e-82 248.0 COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,1S271@1236|Gammaproteobacteria,1X0PP@135613|Chromatiales 135613|Chromatiales S Conserved hypothetical ATP binding protein - - - ko:K06945 - - - - ko00000 - - - ATP_bind_1 k59_184412_5 713587.THITH_00875 1.07e-37 151.0 2DBSQ@1|root,2ZATE@2|Bacteria,1N58C@1224|Proteobacteria,1SAPH@1236|Gammaproteobacteria,1X12X@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_184412_8 768671.ThimaDRAFT_0992 9.03e-43 145.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_54163_1 1218352.B597_020845 0.0 1476.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1Z3UU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria U MMPL family mexF - - ko:K18299,ko:K19585 - M00641,M00767 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.16,2.A.6.2.47 - - ACR_tran k59_54163_2 391008.Smal_1567 1.17e-11 64.7 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1X38S@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18298,ko:K19586 - M00641,M00767 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.47,8.A.1 - - Biotin_lipoyl_2,HlyD_D23 k59_80532_1 768671.ThimaDRAFT_3125 4.25e-73 233.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WX0J@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_73557_1 1123269.NX02_29030 6.25e-15 81.3 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,2K2U3@204457|Sphingomonadales 204457|Sphingomonadales E C-terminus of AA_permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_9092_1 768671.ThimaDRAFT_2410 7.64e-28 107.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K13041 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_60923_1 880072.Desac_2476 1.28e-70 222.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,2MQ75@213462|Syntrophobacterales 28221|Deltaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_101706_3 1049564.TevJSym_ae00250 1.72e-63 202.0 2FG9E@1|root,3485S@2|Bacteria,1P398@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_134685_1 1033802.SSPSH_003561 7.71e-82 252.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_56221_2 1121937.AUHJ01000026_gene35 1.57e-80 245.0 2DMDM@1|root,32Q85@2|Bacteria,1RGD5@1224|Proteobacteria 1224|Proteobacteria S RES domain - - - - - - - - - - - - RES k59_56221_3 1121937.AUHJ01000026_gene34 3.89e-48 162.0 2EHM5@1|root,33BCX@2|Bacteria,1NECF@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_24717_1 318161.Sden_3218 2.06e-69 229.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,2Q8Z8@267890|Shewanellaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_24717_2 1049564.TevJSym_ab00760 3.95e-164 482.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria 1236|Gammaproteobacteria V DNA Recombination protein RmuC rmuC GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K09760 - - - - ko00000 - - - RmuC k59_153869_7 357804.Ping_0445 2.15e-94 316.0 COG5434@1|root,COG5434@2|Bacteria 2|Bacteria M polygalacturonase activity - - - - - - - - - - - - Beta_helix,CBM_35,Pectate_lyase_3 k59_134806_1 768671.ThimaDRAFT_2370 1.05e-66 217.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales 135613|Chromatiales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_134806_2 1049564.TevJSym_ag01060 8.11e-76 237.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1J4FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing LysM domain lysM - - - - - - - - - - - LysM k59_82891_1 1123037.AUDE01000034_gene3358 4.05e-07 52.4 COG3385@1|root,COG3385@2|Bacteria,4NQCC@976|Bacteroidetes,1I9PY@117743|Flavobacteriia 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_82891_2 1408433.JHXV01000029_gene3084 2.2e-10 62.8 COG3385@1|root,COG3385@2|Bacteria,4NQCC@976|Bacteroidetes,1I9PY@117743|Flavobacteriia 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_198912_1 2340.JV46_03750 1.48e-87 280.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1J4DW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_198912_2 1269813.ATUL01000017_gene2536 1.33e-32 117.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1WYM1@135613|Chromatiales 135613|Chromatiales U TIGRFAM preprotein translocase, YajC subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_198912_3 1120953.AUBH01000005_gene2477 3.1e-23 98.6 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,46D8K@72275|Alteromonadaceae 1236|Gammaproteobacteria I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_70296_1 335543.Sfum_2978 1.54e-30 112.0 2E47B@1|root,32Z37@2|Bacteria,1NC7T@1224|Proteobacteria,42VYF@68525|delta/epsilon subdivisions,2WRN2@28221|Deltaproteobacteria,2MSH3@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_96622_1 706587.Desti_5522 2.48e-60 195.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,43AWM@68525|delta/epsilon subdivisions,2X6AU@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_37755_1 675813.VIB_002050 1.11e-46 168.0 COG3677@1|root,COG3677@2|Bacteria,1N87H@1224|Proteobacteria,1RS9H@1236|Gammaproteobacteria,1XY3N@135623|Vibrionales 135623|Vibrionales L TniQ - - - - - - - - - - - - TniQ,TnsD k59_122529_4 491952.Mar181_1875 1.19e-27 107.0 COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1S6AR@1236|Gammaproteobacteria,1XK8T@135619|Oceanospirillales 135619|Oceanospirillales T Universal stress protein uspA - - ko:K06149 - - - - ko00000 - - - Usp k59_122529_6 1242864.D187_006392 3.62e-14 77.4 COG0642@1|root,COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria,2YUF6@29|Myxococcales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_108972_1 95619.PM1_0226640 4.62e-08 51.6 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0235 family yggU - - ko:K09131 - - - - ko00000 - - - DUF167 k59_108972_2 1049564.TevJSym_am00160 7.19e-114 346.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1J9QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_192882_2 1049564.TevJSym_ae00470 1e-312 880.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564 - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_192882_3 1049564.TevJSym_ae00480 7.94e-216 630.0 COG1444@1|root,COG1444@2|Bacteria,1NBA4@1224|Proteobacteria,1RPAM@1236|Gammaproteobacteria,1J585@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) tmcA GO:0000049,GO:0000154,GO:0002097,GO:0002101,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0051391,GO:0051392,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1904812,GO:1990882,GO:1990883,GO:1990884 2.3.1.193 ko:K06957 - - - - ko00000,ko01000,ko03016 - - - DUF1726,GNAT_acetyltr_2,Helicase_RecD,tRNA_bind_3 k59_89212_1 1268068.PG5_54460 3.61e-49 170.0 COG2199@1|root,COG3706@2|Bacteria,1RDI8@1224|Proteobacteria,1S436@1236|Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - GGDEF k59_89212_2 870187.Thini_0200 1.15e-114 343.0 COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,1RZ7R@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_180135_1 1121405.dsmv_0131 1.31e-108 328.0 COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MIFH@213118|Desulfobacterales 28221|Deltaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase,His_biosynth k59_50430_1 439235.Dalk_4397 6.83e-86 270.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MIJV@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_140932_1 1049564.TevJSym_aa01890 2.13e-122 367.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_56230_2 335543.Sfum_0150 2.13e-53 183.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2MRDR@213462|Syntrophobacterales 28221|Deltaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_4385_2 1249627.D779_4123 2.69e-31 112.0 2E0R6@1|root,32W9H@2|Bacteria,1N4U9@1224|Proteobacteria,1SC7F@1236|Gammaproteobacteria,1WZ37@135613|Chromatiales 135613|Chromatiales S NifZ domain - - - ko:K02597 - - - - ko00000 - - - NifZ k59_4385_3 580332.Slit_0804 2.57e-45 149.0 COG0316@1|root,COG0316@2|Bacteria,1MZTE@1224|Proteobacteria,2VUJT@28216|Betaproteobacteria,44WGU@713636|Nitrosomonadales 28216|Betaproteobacteria S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn k59_4385_4 768671.ThimaDRAFT_3597 3.6e-71 221.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1WW3I@135613|Chromatiales 135613|Chromatiales C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N k59_140934_1 228405.HNE_3446 8.01e-53 179.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_45063_1 1049564.TevJSym_ac01240 2.55e-114 336.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1J51G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2767 NAD_kinase k59_198925_1 697282.Mettu_4130 8.57e-17 84.3 COG3259@1|root,COG3259@2|Bacteria,1RFVW@1224|Proteobacteria,1T354@1236|Gammaproteobacteria,1XG2J@135618|Methylococcales 135618|Methylococcales C Nickel-dependent hydrogenase - - - - - - - - - - - - - k59_115090_2 1234664.AMRO01000003_gene636 4.59e-46 166.0 COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,4HCHQ@91061|Bacilli,1WE71@129337|Geobacillus 91061|Bacilli J RNA-binding PUA-like domain of methyltransferase RsmF rsmF - - - - - - - - - - - Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI k59_45064_1 314278.NB231_06611 3.93e-52 170.0 COG5433@1|root,COG5433@2|Bacteria,1RAHU@1224|Proteobacteria,1S1TZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Domain of unknown function (DUF4338) - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338 k59_11740_1 926569.ANT_00920 4.5e-28 117.0 COG2199@1|root,COG2199@2|Bacteria 2|Bacteria T diguanylate cyclase activity - - - - - - - - - - - - GAF_2,GGDEF,PAS_4,PAS_8,PAS_9 k59_11740_2 1238182.C882_4434 2.57e-22 100.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQI7@204441|Rhodospirillales 204441|Rhodospirillales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_134812_2 1049564.TevJSym_ao00390 1.78e-29 110.0 COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,1SGEP@1236|Gammaproteobacteria,1JBHN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PFAM VanZ - - - - - - - - - - - - VanZ k59_134812_3 1049564.TevJSym_ao00380 3.16e-29 116.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1J9K4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_192892_1 543632.JOJL01000001_gene7567 8.04e-12 70.1 COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DBGJ@85008|Micromonosporales 201174|Actinobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigA - - ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_89223_1 1121406.JAEX01000001_gene427 2.7e-59 194.0 2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MB2J@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_45067_1 335543.Sfum_3369 1.81e-88 290.0 COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2MQUA@213462|Syntrophobacterales 28221|Deltaproteobacteria L DSHCT - - - - - - - - - - - - DEAD,DSHCT,DUF3516,Helicase_C k59_187095_1 443143.GM18_0017 5.45e-51 177.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,42NZ4@68525|delta/epsilon subdivisions,2WQTT@28221|Deltaproteobacteria,43VJV@69541|Desulfuromonadales 28221|Deltaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_108983_2 1049564.TevJSym_ab00150 8.18e-111 346.0 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1JB0I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_70316_1 323097.Nham_1671 1.54e-42 142.0 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2U98B@28211|Alphaproteobacteria,3JYSH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the ArsC family MA20_27840 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_166818_1 880072.Desac_0306 2.3e-117 343.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2MQTU@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1986 Pan_kinase k59_166818_2 82654.Pse7367_1750 1.35e-11 66.6 COG1619@1|root,COG1619@2|Bacteria,1G059@1117|Cyanobacteria,1H7XC@1150|Oscillatoriales 1117|Cyanobacteria V microcin C7 resistance - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_141191_2 870187.Thini_3072 6.06e-48 159.0 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,45ZZT@72273|Thiotrichales 72273|Thiotrichales O Glutaredoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Glutaredoxin,Redoxin k59_24964_3 264732.Moth_0831 1.29e-20 101.0 COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,42IC3@68295|Thermoanaerobacterales 186801|Clostridia C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_24964_4 1487923.DP73_16310 1.64e-21 104.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,260S8@186807|Peptococcaceae 186801|Clostridia C PFAM Radical SAM scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_11989_1 1049564.TevJSym_am00440 1.24e-185 528.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1J4X4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1778,iPC815.YPO3335 Fumerase,Fumerase_C k59_187310_1 1121861.KB899934_gene517 3.19e-07 50.8 COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,2UBRM@28211|Alphaproteobacteria,2JTQT@204441|Rhodospirillales 204441|Rhodospirillales S YHS domain - - - - - - - - - - - - YHS k59_147923_3 257310.BB0485 6.88e-15 70.1 294HZ@1|root,2ZRXM@2|Bacteria,1P8SB@1224|Proteobacteria,2WDBW@28216|Betaproteobacteria,3T8ED@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_147923_6 1470593.BW43_00058 1.3e-145 422.0 COG3704@1|root,COG3704@2|Bacteria,1P5RF@1224|Proteobacteria 1224|Proteobacteria U Conjugal transfer protein virB6 - - ko:K03201 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbL k59_147923_7 380358.XALC_2641 6.45e-32 113.0 2DSAS@1|root,33F9P@2|Bacteria,1MZNZ@1224|Proteobacteria,1SSMW@1236|Gammaproteobacteria,1XBU5@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_147923_8 1532557.JL37_21410 4.24e-58 185.0 2CG3T@1|root,2ZFS2@2|Bacteria,1PB4W@1224|Proteobacteria,2WAKB@28216|Betaproteobacteria,3T621@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_147923_9 1219031.BBJR01000085_gene888 2.43e-126 364.0 COG5314@1|root,COG5314@2|Bacteria,1R6SS@1224|Proteobacteria,2VWXZ@28216|Betaproteobacteria,4AFD3@80864|Comamonadaceae 28216|Betaproteobacteria U Type IV secretion system proteins - - - ko:K03200 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS k59_56405_1 317025.Tcr_0879 3.35e-87 283.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_173200_2 1121441.AUCX01000008_gene2284 2.91e-32 118.0 2AD08@1|root,312N7@2|Bacteria,1NDC4@1224|Proteobacteria,42VQI@68525|delta/epsilon subdivisions,2WS8T@28221|Deltaproteobacteria,2MBKX@213115|Desulfovibrionales 28221|Deltaproteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_24972_1 1304885.AUEY01000016_gene3060 1.21e-33 133.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_195891_1 339670.Bamb_6627 4.17e-18 82.4 COG5314@1|root,COG5314@2|Bacteria,1MXYH@1224|Proteobacteria,2VKWT@28216|Betaproteobacteria,1K6WF@119060|Burkholderiaceae 28216|Betaproteobacteria U TRANSFER protein - - - ko:K20266 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - - k59_40903_2 1049564.TevJSym_ao00180 1.3e-146 416.0 COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RZ6E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM TIGR00266 family protein - - - - - - - - - - - - AIM24 k59_40903_3 1304888.ATWF01000001_gene2328 1.33e-07 52.0 COG1723@1|root,COG1723@2|Bacteria,2GGDK@200930|Deferribacteres 200930|Deferribacteres S Uncharacterised ACR, YagE family COG1723 - - - - - - - - - - - - DUF155 k59_157361_1 880072.Desac_0816 5.31e-69 221.0 COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_17 k59_34275_1 244582.JQAK01000001_gene2196 1.32e-08 53.5 28TNW@1|root,2ZFWC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_60180_2 335543.Sfum_0075 2.1e-56 191.0 COG1355@1|root,COG1355@2|Bacteria,1N5H1@1224|Proteobacteria,42TIN@68525|delta/epsilon subdivisions,2WR24@28221|Deltaproteobacteria,2MQK2@213462|Syntrophobacterales 28221|Deltaproteobacteria S Memo-like protein - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_92725_1 1255043.TVNIR_1189 7.62e-16 79.3 COG1653@1|root,COG1653@2|Bacteria,1R5DC@1224|Proteobacteria,1S3CM@1236|Gammaproteobacteria,1X05G@135613|Chromatiales 135613|Chromatiales G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 k59_92725_2 1278309.KB907102_gene92 1.11e-142 406.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1XIIM@135619|Oceanospirillales 135619|Oceanospirillales IQ reductase phbB - 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_92725_3 313612.L8106_28181 8.88e-23 109.0 COG0834@1|root,COG2199@1|root,COG0834@2|Bacteria,COG3706@2|Bacteria,1G7R7@1117|Cyanobacteria,1HC6K@1150|Oscillatoriales 1117|Cyanobacteria T COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain - - - - - - - - - - - - GGDEF,SBP_bac_3 k59_21395_1 641112.ACOK01000001_gene3568 3.8e-09 63.5 COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,3WGWG@541000|Ruminococcaceae 186801|Clostridia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_21743_1 398578.Daci_3267 1.33e-43 165.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4AA96@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9 k59_196200_1 1049564.TevJSym_aw00350 1.57e-06 51.2 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1J5N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_196200_2 713586.KB900536_gene333 3.87e-25 100.0 COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,1T20E@1236|Gammaproteobacteria,1X2SH@135613|Chromatiales 135613|Chromatiales G Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_60432_2 1049564.TevJSym_bc00170 1.73e-258 713.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1J5M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt k59_99038_1 485916.Dtox_4019 1.52e-65 213.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia 186801|Clostridia L Reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_73195_1 1101189.AQUO01000002_gene426 5.99e-43 149.0 COG0685@1|root,COG0685@2|Bacteria,1RHDY@1224|Proteobacteria,2U4I0@28211|Alphaproteobacteria,2PYRU@265|Paracoccus 28211|Alphaproteobacteria E Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_86365_1 323261.Noc_1747 4.76e-12 67.4 COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN - - - ko:K07003 - - - - ko00000 - - - MMPL k59_164069_1 658187.LDG_6378 4.25e-14 73.6 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1JDQX@118969|Legionellales 118969|Legionellales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF,Guanylate_cyc,PAS_9 k59_34586_1 1049564.TevJSym_af00210 1.04e-100 306.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1J4NW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_105664_1 56780.SYN_01191 8.84e-88 272.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MQY6@213462|Syntrophobacterales 28221|Deltaproteobacteria KT PFAM Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_93104_1 316067.Geob_2356 1.82e-123 363.0 COG4591@1|root,COG4591@2|Bacteria,1QXNJ@1224|Proteobacteria,43C4I@68525|delta/epsilon subdivisions,2X7EY@28221|Deltaproteobacteria,43TJA@69541|Desulfuromonadales 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_47417_1 795359.TOPB45_0317 1.79e-68 213.0 COG2220@1|root,COG2220@2|Bacteria 2|Bacteria S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - - - - - - - - - - Lactamase_B_3 k59_119043_1 880072.Desac_2350 1.37e-47 162.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,42PP6@68525|delta/epsilon subdivisions,2WJN2@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM PFAM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_1831_1 555778.Hneap_0412 1.75e-94 289.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1X26N@135613|Chromatiales 135613|Chromatiales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_8614_1 314345.SPV1_02207 1.43e-84 256.0 COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria 1224|Proteobacteria P ion transport protein ccaA - - ko:K08714 - - - - ko00000,ko02000 1.A.1.14 - - Ion_trans k59_41235_2 644282.Deba_1203 1.25e-45 155.0 COG2043@1|root,COG2043@2|Bacteria,1R8EH@1224|Proteobacteria,42Q2F@68525|delta/epsilon subdivisions,2WJZN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_60444_1 237368.SCABRO_02856 5.2e-29 119.0 28NDD@1|root,2ZBG6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1 k59_177225_2 658187.LDG_8608 3.3e-62 200.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1JDCG@118969|Legionellales 118969|Legionellales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_73202_1 795359.TOPB45_0627 1.03e-29 110.0 COG2905@1|root,COG2905@2|Bacteria,2GHVH@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_164081_1 340.xcc-b100_2967 3.03e-64 207.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1X449@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_60449_1 1049564.TevJSym_as00440 7.85e-140 416.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_183964_1 933262.AXAM01000016_gene146 6.12e-87 256.0 COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2MJMB@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_203053_2 765911.Thivi_1736 4.57e-29 108.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_53803_1 1336234.JAGN01000019_gene29 6.97e-13 74.7 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H9NZ@91061|Bacilli,27FSR@186828|Carnobacteriaceae 91061|Bacilli L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_144922_1 1049564.TevJSym_bb00160 4.58e-25 99.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_144922_2 1049564.TevJSym_bb00170 3.72e-60 192.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1J6N8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3168 Tfp pilus assembly protein PilP pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_144922_3 1049564.TevJSym_bb00180 0.0 922.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1J4IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway, component pilQ GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_144922_4 765911.Thivi_2858 4.12e-80 242.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1WWA2@135613|Chromatiales 135613|Chromatiales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_144922_5 765913.ThidrDRAFT_2189 6.52e-158 454.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_144922_6 1049564.TevJSym_bb00220 1.35e-33 141.0 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein - - - ko:K00666,ko:K03561,ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko01004,ko02000,ko03110 1.A.30.2.1 - - AMP-binding,AMP-binding_C,DUF1499,DUF4157 k59_144922_7 1049564.TevJSym_bb00230 3.86e-119 378.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_157661_1 335543.Sfum_2837 6.49e-11 67.8 COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,42QA2@68525|delta/epsilon subdivisions,2X7QC@28221|Deltaproteobacteria,2MQRX@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,MASE3,PAS_9 k59_41253_1 395493.BegalDRAFT_2888 2.73e-102 306.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales 72273|Thiotrichales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_125534_1 1049564.TevJSym_ad00570 1.24e-29 110.0 COG1633@1|root,COG1633@2|Bacteria,1RDK1@1224|Proteobacteria,1S55F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_125534_2 1049564.TevJSym_ad00560 6.8e-317 875.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2 k59_137950_1 1247726.MIM_c18670 5.07e-13 72.4 COG1028@1|root,COG1028@2|Bacteria,1RH9P@1224|Proteobacteria,2VNFB@28216|Betaproteobacteria,3T9NM@506|Alcaligenaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short k59_137950_2 933262.AXAM01000001_gene356 8.23e-54 176.0 2EFDI@1|root,3396C@2|Bacteria,1N9D7@1224|Proteobacteria,42W2W@68525|delta/epsilon subdivisions,2WR8J@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_137950_3 1121405.dsmv_3391 4.13e-134 403.0 COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2MIVJ@213118|Desulfobacterales 28221|Deltaproteobacteria C Fe-S cluster domain protein - - - - - - - - - - - - FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_28052_1 335543.Sfum_3598 1.54e-11 59.3 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2WRJR@28221|Deltaproteobacteria,2MS5B@213462|Syntrophobacterales 28221|Deltaproteobacteria CO Thioredoxin domain - - - - - - - - - - - - Thioredoxin_3 k59_28052_2 644282.Deba_0054 1.18e-47 156.0 COG4273@1|root,COG4273@2|Bacteria,1MZED@1224|Proteobacteria,42UH2@68525|delta/epsilon subdivisions,2WQNQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DGC domain protein - - - - - - - - - - - - DGC k59_41257_1 1254432.SCE1572_14660 1.07e-47 166.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_47437_1 1121405.dsmv_2750 1.17e-99 305.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Starch synthase catalytic - - 2.4.1.21,3.2.1.1 ko:K00703,ko:K01176 ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973 M00565 R02108,R02112,R02421,R11262 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GH13,GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_125538_1 2340.JV46_08510 3.2e-10 56.6 2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1JB6N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_125538_2 1157708.KB907450_gene5647 1.14e-18 88.2 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,2VINN@28216|Betaproteobacteria,4ABA4@80864|Comamonadaceae 28216|Betaproteobacteria L Exonuclease, RNase T and DNA polymerase III sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_170945_1 309799.DICTH_1693 9.05e-38 135.0 COG1913@1|root,COG1913@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 k59_170945_2 330214.NIDE3498 3.97e-79 263.0 COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria 2|Bacteria KT transcription factor binding fhlA GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat k59_1846_1 1049564.TevJSym_ab01650 0.0 1204.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1J54G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_60470_1 335543.Sfum_1230 8.25e-37 128.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria,2MQNU@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_60470_2 518766.Rmar_1711 9.28e-08 55.5 COG0618@1|root,COG0618@2|Bacteria,4NEXE@976|Bacteroidetes,1FIPH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S DHH family nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_183982_1 97139.C824_00570 7.86e-33 120.0 COG1943@1|root,COG1943@2|Bacteria,1V53Y@1239|Firmicutes,25CMQ@186801|Clostridia,36VU7@31979|Clostridiaceae 186801|Clostridia L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_53814_1 697282.Mettu_0751 1.54e-18 79.0 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1XFQ0@135618|Methylococcales 135618|Methylococcales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_53814_2 1123377.AUIV01000010_gene2202 2.7e-24 99.8 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1X40B@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_157667_1 1049564.TevJSym_ap00750 3.38e-123 360.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1J6GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin ybbN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077 - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_73208_1 1535422.ND16A_0733 6.77e-35 131.0 COG1575@1|root,COG1575@2|Bacteria,1QHA9@1224|Proteobacteria,1TEVV@1236|Gammaproteobacteria,2Q7F8@267889|Colwelliaceae 1236|Gammaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_203071_1 945713.IALB_1465 4.54e-56 197.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - CCG,Fer4_8 k59_53817_1 2340.JV46_28740 5.47e-51 180.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_125547_1 1944.JOAZ01000011_gene6307 9.97e-29 117.0 COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,418R1@629295|Streptomyces griseus group 201174|Actinobacteria T Tyrosine phosphatase family - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - Y_phosphatase3 k59_8645_1 439235.Dalk_0234 2.87e-33 132.0 COG3385@1|root,COG3385@2|Bacteria,1RCTP@1224|Proteobacteria,431NI@68525|delta/epsilon subdivisions,2WWWQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_28063_1 1210908.HSB1_33250 1.93e-13 68.9 COG1131@1|root,arCOG00194@2157|Archaea,2XTCU@28890|Euryarchaeota,23SM1@183963|Halobacteria 183963|Halobacteria E ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_28063_2 1049564.TevJSym_al00280 1.77e-96 290.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1J4P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_34856_4 1123393.KB891332_gene2814 1.61e-54 196.0 COG2206@1|root,COG2206@2|Bacteria,1MWDU@1224|Proteobacteria,2VIAF@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD_5 k59_107897_1 1049564.TevJSym_ac01150 3.02e-142 416.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1J51N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509 - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_19,TPR_7,TPR_8 k59_49491_2 1167006.UWK_01150 8.19e-52 181.0 COG2070@1|root,COG2070@2|Bacteria,1R8ZS@1224|Proteobacteria,42N1N@68525|delta/epsilon subdivisions,2WMIF@28221|Deltaproteobacteria,2MMMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S 2-Nitropropane dioxygenase - - - - - - - - - - - - - k59_165890_1 335543.Sfum_3062 4.37e-21 96.7 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2WNEI@28221|Deltaproteobacteria,2MRXM@213462|Syntrophobacterales 28221|Deltaproteobacteria S Divergent polysaccharide deacetylase yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_55439_2 933262.AXAM01000050_gene3477 7.65e-42 140.0 COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42T7I@68525|delta/epsilon subdivisions,2WPNZ@28221|Deltaproteobacteria,2MK3Z@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_186345_1 323261.Noc_2783 8.73e-17 76.3 COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1WZDQ@135613|Chromatiales 135613|Chromatiales S NTP binding protein (Contains STAS domain) - - - ko:K07122 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - STAS_2 k59_75228_1 485913.Krac_4010 9.16e-52 178.0 COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi 200795|Chloroflexi L sptr a7nhu5 - - - - - - - - - - - - DDE_5 k59_198285_1 575588.ACPN01000217_gene539 1.21e-27 111.0 COG3039@1|root,COG3039@2|Bacteria,1MXP1@1224|Proteobacteria,1RSBM@1236|Gammaproteobacteria,3NIY5@468|Moraxellaceae 1236|Gammaproteobacteria L There are 9 addittional ORFs identical to this one - - - - - - - - - - - - DDE_Tnp_1_3 k59_140151_1 143224.JQMD01000002_gene3442 9.99e-56 185.0 COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,1HYIB@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_128278_2 472759.Nhal_2251 1.11e-55 181.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1X0DE@135613|Chromatiales 135613|Chromatiales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_88551_1 1191523.MROS_0168 2.56e-96 294.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding yebA - - - - - - - - - - - OapA,Peptidase_M23 k59_3754_2 1121403.AUCV01000014_gene4615 1.78e-80 260.0 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - - - - - - - - - - HDOD,Response_reg k59_3754_3 1049564.TevJSym_af00900 7.42e-103 313.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S2RH@1236|Gammaproteobacteria,1JBJA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - HD_5,Response_reg k59_121718_2 1123322.KB904713_gene5177 2.36e-22 102.0 COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria 201174|Actinobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MFS_1,Thymidylate_kin k59_108141_2 1123400.KB904755_gene2592 1.32e-140 401.0 COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,1RY5U@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059,ko:K18335 ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R10690,R11671 RC00029,RC00089,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_108141_3 377629.TERTU_2684 3.21e-204 593.0 COG0663@1|root,COG2755@1|root,COG0663@2|Bacteria,COG2755@2|Bacteria,1Q0SI@1224|Proteobacteria,1S04W@1236|Gammaproteobacteria,2PPK5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Carbohydrate binding module (family 35) - - - - - - - - - - - - CBM_2 k59_205091_1 1266925.JHVX01000005_gene1870 1.57e-17 82.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,3728Q@32003|Nitrosomonadales 28216|Betaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_205091_2 550540.Fbal_0347 3.05e-71 229.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_16755_1 999550.KI421507_gene1978 3.74e-116 347.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG3335 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_44271_1 616991.JPOO01000001_gene4208 8.41e-12 73.2 COG0823@1|root,COG1520@1|root,COG2133@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1HX9D@117743|Flavobacteriia 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH k59_82273_1 338963.Pcar_1370 1.27e-71 231.0 COG0768@1|root,COG0768@2|Bacteria,1R7A0@1224|Proteobacteria,42MJC@68525|delta/epsilon subdivisions,2WJZ2@28221|Deltaproteobacteria,43T9I@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM penicillin-binding protein transpeptidase pbp4 - - - - - - - - - - - Transpeptidase k59_23995_1 215803.DB30_5754 5.21e-100 298.0 COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,42QYJ@68525|delta/epsilon subdivisions,2WN82@28221|Deltaproteobacteria,2YX3U@29|Myxococcales 28221|Deltaproteobacteria S Phenazine biosynthesis-like protein - - - - - - - - - - - - PhzC-PhzF k59_49739_1 883.DvMF_1567 1.19e-53 182.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2M8CC@213115|Desulfovibrionales 28221|Deltaproteobacteria C FAD linked oxidase glcD - 1.1.2.4,1.1.3.15 ko:K00102,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_49739_2 1121405.dsmv_1970 7.68e-19 79.3 COG2329@1|root,COG2329@2|Bacteria,1NBCH@1224|Proteobacteria,42VX2@68525|delta/epsilon subdivisions,2WRPB@28221|Deltaproteobacteria,2MM0B@213118|Desulfobacterales 28221|Deltaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_134135_1 1049564.TevJSym_aj00110 5.57e-67 215.0 COG2831@1|root,COG2831@2|Bacteria,1QW38@1224|Proteobacteria,1T2R4@1236|Gammaproteobacteria,1J75U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_23997_1 1232437.KL662057_gene3905 7.02e-47 158.0 COG2191@1|root,COG2191@2|Bacteria,1RBNI@1224|Proteobacteria,42QZP@68525|delta/epsilon subdivisions,2WMY0@28221|Deltaproteobacteria,2MJH4@213118|Desulfobacterales 28221|Deltaproteobacteria C FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - FmdE,zf-dskA_traR k59_153291_1 1499967.BAYZ01000093_gene4021 4.22e-76 240.0 COG1593@1|root,COG1593@2|Bacteria 2|Bacteria G mannitol 2-dehydrogenase activity - - - - - - - - - - - - DctM k59_128288_2 765913.ThidrDRAFT_2902 2.11e-34 118.0 COG2768@1|root,COG2768@2|Bacteria,1QVC1@1224|Proteobacteria,1T4SW@1236|Gammaproteobacteria,1WZ7M@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin - - - - - - - - - - - - Fer4 k59_128288_3 768671.ThimaDRAFT_1259 2.64e-31 110.0 COG5554@1|root,COG5554@2|Bacteria,1N7DQ@1224|Proteobacteria,1SD1T@1236|Gammaproteobacteria,1WYZ7@135613|Chromatiales 135613|Chromatiales Q PFAM NifT FixU - - - ko:K02593 - - - - ko00000 - - - NifT k59_128288_4 870187.Thini_4010 2.42e-172 493.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,1RMV3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation nifK - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_198302_1 251229.Chro_0078 1.49e-137 431.0 COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1G0XE@1117|Cyanobacteria,3VM88@52604|Pleurocapsales 1117|Cyanobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_49744_2 335543.Sfum_0388 4.5e-59 196.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MB6@68525|delta/epsilon subdivisions,2WJMI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Acetyl-CoA hydrolase transferase ato-2 - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - iAF987.Gmet_1125 AcetylCoA_hyd_C,AcetylCoA_hydro k59_140154_1 768066.HELO_4470 2.06e-72 232.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XI7M@135619|Oceanospirillales 135619|Oceanospirillales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_140154_2 765913.ThidrDRAFT_2150 9.32e-223 634.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales 135613|Chromatiales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_140154_3 477228.YO5_14830 1.1e-30 109.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1Z36Q@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K08998 - - - - ko00000 - - - Haemolytic k59_140154_4 396588.Tgr7_3320 8.69e-25 97.4 COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1WYV8@135613|Chromatiales 135613|Chromatiales J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_121739_1 1049564.TevJSym_ar00010 1.95e-58 186.0 COG3154@1|root,COG3154@2|Bacteria,1RB7T@1224|Proteobacteria,1RMJD@1236|Gammaproteobacteria,1J6X9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I SCP-2 sterol transfer family yhbT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - SCP2 k59_146995_1 177437.HRM2_22180 8.49e-61 196.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2MJMQ@213118|Desulfobacterales 28221|Deltaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_88561_2 1049564.TevJSym_au00100 1.06e-154 439.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1J5DH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0840 Hexapep,SATase_N k59_179531_1 1121403.AUCV01000003_gene1854 1.39e-43 148.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42S1G@68525|delta/epsilon subdivisions,2X6B6@28221|Deltaproteobacteria,2MJTV@213118|Desulfobacterales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_82277_2 99598.Cal7507_3726 1.34e-133 407.0 COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria,1HMQN@1161|Nostocales 1117|Cyanobacteria O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_75248_1 1249627.D779_2413 9.98e-153 443.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales 135613|Chromatiales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_128296_1 556268.OFAG_00889 6.69e-69 223.0 COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,2VK83@28216|Betaproteobacteria,4740A@75682|Oxalobacteraceae 28216|Betaproteobacteria M Glycosyl transferase family 21 pgaC - - ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2 k59_95974_2 1317124.DW2_08577 3.16e-27 110.0 COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2U0HG@28211|Alphaproteobacteria,2XP70@285107|Thioclava 28211|Alphaproteobacteria C Rubredoxin hupJ - - - - - - - - - - - NiFe-hyd_HybE,Rubredoxin k59_16776_1 519989.ECTPHS_00755 4.26e-160 454.0 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,1RRHZ@1236|Gammaproteobacteria,1WW8V@135613|Chromatiales 135613|Chromatiales S Fic/DOC family - - - - - - - - - - - - Fic k59_108169_1 1265505.ATUG01000001_gene4632 4.28e-74 231.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,42PRH@68525|delta/epsilon subdivisions,2WPXH@28221|Deltaproteobacteria,2MJR0@213118|Desulfobacterales 28221|Deltaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ,MobB k59_88566_1 911045.PSE_p0371 2.36e-06 53.1 COG1638@1|root,COG1638@2|Bacteria,1P3MK@1224|Proteobacteria,2TVQB@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_128301_1 762982.HMPREF9442_00599 3.14e-14 77.4 COG0188@1|root,COG0188@2|Bacteria,4NDWQ@976|Bacteroidetes,2FMCP@200643|Bacteroidia 976|Bacteroidetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_205114_1 1232410.KI421425_gene1554 6.69e-127 405.0 COG1361@1|root,COG1361@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_179538_1 338966.Ppro_3716 6.61e-49 164.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42R4P@68525|delta/epsilon subdivisions,2X5AT@28221|Deltaproteobacteria,43W1U@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_30220_1 314285.KT71_08620 1.78e-121 359.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1J9WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase, Mutator family - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_101136_1 1499686.BN1079_03248 6.09e-18 84.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - SpoIIM k59_101136_2 1278309.KB907101_gene518 2.17e-82 253.0 COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,1S566@1236|Gammaproteobacteria,1XK0Q@135619|Oceanospirillales 135619|Oceanospirillales S membrane protein domain - - - - - - - - - - - - RDD k59_101136_3 765912.Thimo_3435 4.19e-51 184.0 COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S0TC@1236|Gammaproteobacteria,1WWZI@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_147004_1 1049564.TevJSym_as00640 2.51e-147 449.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1J4D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_198321_1 1095769.CAHF01000006_gene1787 1.14e-07 58.2 COG0559@1|root,COG0559@2|Bacteria,1MXHF@1224|Proteobacteria,2VUM8@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_16780_2 28532.XP_010541068.1 3.88e-07 56.2 COG1073@1|root,KOG4667@2759|Eukaryota,37JBE@33090|Viridiplantae,3GB8U@35493|Streptophyta,3HW6N@3699|Brassicales 35493|Streptophyta I Esterase lipase thioesterase family protein - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_3777_1 1249627.D779_2414 1.84e-32 115.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1WYM5@135613|Chromatiales 135613|Chromatiales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_3777_3 2340.JV46_16770 4.92e-87 264.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1J5E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_205120_1 1232437.KL661978_gene3834 2.98e-34 124.0 COG3807@1|root,COG3807@2|Bacteria,1RIYJ@1224|Proteobacteria,42SNK@68525|delta/epsilon subdivisions,2WPNS@28221|Deltaproteobacteria,2MK8E@213118|Desulfobacterales 28221|Deltaproteobacteria S SH3 domain - - - - - - - - - - - - SH3_4 k59_134160_1 933262.AXAM01000014_gene233 6.64e-113 336.0 COG0003@1|root,COG0071@1|root,COG0003@2|Bacteria,COG0071@2|Bacteria,1MUTX@1224|Proteobacteria,42P0N@68525|delta/epsilon subdivisions,2WKQ0@28221|Deltaproteobacteria,2MJJ2@213118|Desulfobacterales 28221|Deltaproteobacteria P Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_160105_1 439235.Dalk_0681 1.3e-147 436.0 COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit - - 2.3.1.169 ko:K14138 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R08433,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhC k59_24260_1 335543.Sfum_3750 4.84e-51 180.0 COG0673@1|root,COG3494@1|root,COG0673@2|Bacteria,COG3494@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,2MR8J@213462|Syntrophobacterales 28221|Deltaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA,GFO_IDH_MocA_C k59_16993_1 1121405.dsmv_0507 3.62e-09 57.8 COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42YHK@68525|delta/epsilon subdivisions,2WUDF@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_147216_1 205918.Psyr_4211 8.11e-19 95.1 COG0747@1|root,COG0747@2|Bacteria,1R410@1224|Proteobacteria,1RRXP@1236|Gammaproteobacteria,1Z9DR@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_108472_2 393283.XP_007827499.1 6.31e-32 122.0 COG1878@1|root,2S85N@2759|Eukaryota,39NMP@33154|Opisthokonta,3PDMW@4751|Fungi 4751|Fungi S Putative cyclase - - - - - - - - - - - - Cyclase k59_128529_1 1278073.MYSTI_02313 1.19e-55 195.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YU3Z@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_134372_1 1150599.MPHLEI_00205 0.000175 44.7 COG2963@1|root,COG2963@2|Bacteria,2GRDS@201174|Actinobacteria,23EYP@1762|Mycobacteriaceae 201174|Actinobacteria L PFAM Transposase IS3 IS911family - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_168884_1 765913.ThidrDRAFT_1702 7.19e-86 260.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales 135613|Chromatiales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_168884_2 1049564.TevJSym_an00360 7.74e-30 108.0 COG0695@1|root,COG0695@2|Bacteria,1NGUN@1224|Proteobacteria 1224|Proteobacteria O Glutaredoxin - - - - - - - - - - - - DUF4124,Glutaredoxin k59_123569_1 1117319.PSPO_09959 4.81e-25 106.0 COG0845@1|root,COG0845@2|Bacteria,1R443@1224|Proteobacteria,1RYSM@1236|Gammaproteobacteria,2Q227@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_123569_2 28229.ND2E_0260 1.54e-22 98.2 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q5VA@267889|Colwelliaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_142960_1 1247726.MIM_c33950 5.45e-11 62.4 COG3209@1|root,COG3501@1|root,COG3209@2|Bacteria,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VK4D@28216|Betaproteobacteria 28216|Betaproteobacteria M Rhs element Vgr protein - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD,RHS,RHS_repeat k59_136553_1 232348.ADXL01000066_gene2681 4.26e-44 158.0 COG0367@1|root,COG0367@2|Bacteria,1G1WZ@1117|Cyanobacteria,1GZ2V@1129|Synechococcus 1117|Cyanobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_136553_2 545264.KB898754_gene1802 5.32e-24 99.0 COG0540@1|root,COG0540@2|Bacteria,1R3Q5@1224|Proteobacteria,1RYCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family - - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_117081_2 933262.AXAM01000019_gene1130 1.72e-26 105.0 COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2WN1F@28221|Deltaproteobacteria,2MJPS@213118|Desulfobacterales 28221|Deltaproteobacteria H TIGRFAM siroheme synthase cysG - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M k59_110594_1 391625.PPSIR1_40715 5.57e-84 256.0 COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,42YTV@68525|delta/epsilon subdivisions,2WTY1@28221|Deltaproteobacteria,2YYJ0@29|Myxococcales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - ko:K13775 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short k59_91180_1 1049564.TevJSym_am00220 1.54e-167 477.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1J564@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG5008 Tfp pilus assembly protein, ATPase PilU pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_91180_2 1049564.TevJSym_am00230 3.12e-51 167.0 2AB8D@1|root,310NU@2|Bacteria,1RFGC@1224|Proteobacteria,1S5A2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_91180_3 1049564.TevJSym_am00250 2.63e-44 146.0 COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1J6M4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria IV02_29925 - - - - - - - - - - - DUF1820 k59_91180_4 316067.Geob_3670 1.14e-08 68.6 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,43SWS@69541|Desulfuromonadales 28221|Deltaproteobacteria M RHS protein - - - - - - - - - - - - DUF4150,RHS,RHS_repeat k59_149504_1 472759.Nhal_3163 4.95e-27 114.0 293XF@1|root,2ZRCI@2|Bacteria,1RGQW@1224|Proteobacteria,1S41W@1236|Gammaproteobacteria,1WYA0@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_104086_2 1216007.AOPM01000080_gene1169 4.45e-94 289.0 COG3207@1|root,COG3207@2|Bacteria,1R4R2@1224|Proteobacteria,1RQMJ@1236|Gammaproteobacteria,2Q4KS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria Q Pyoverdine/dityrosine biosynthesis protein pvcA - - - - - - - - - - - DIT1_PvcA k59_104086_3 1124983.PFLCHA0_c09570 1.67e-146 428.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,1YMJH@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_104086_4 561229.Dd1591_3131 2.96e-150 454.0 COG2175@1|root,COG3207@1|root,COG2175@2|Bacteria,COG3207@2|Bacteria,1RJYX@1224|Proteobacteria,1S7ZT@1236|Gammaproteobacteria,2JD2J@204037|Dickeya 1236|Gammaproteobacteria Q Pyoverdine/dityrosine biosynthesis protein pvcA - - - - - - - - - - - DIT1_PvcA,TauD k59_130095_1 933262.AXAM01000008_gene1932 6.08e-159 460.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MIIC@213118|Desulfobacterales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_104087_1 1005048.CFU_0894 1.22e-14 75.9 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,475ME@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_104087_2 243159.AFE_2155 2.45e-178 505.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RYJX@1236|Gammaproteobacteria,2NC3C@225057|Acidithiobacillales 225057|Acidithiobacillales G Belongs to the RuBisCO large chain family - - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_181889_1 1121403.AUCV01000010_gene1383 2.61e-28 113.0 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria 28221|Deltaproteobacteria ET PFAM Extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_6920_1 1236542.BALM01000032_gene2165 7.59e-77 233.0 COG0645@1|root,COG0645@2|Bacteria,1QE18@1224|Proteobacteria,1TACC@1236|Gammaproteobacteria,2QEA8@267890|Shewanellaceae 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - AAA_33 k59_52236_2 1415630.U771_22422 5.47e-05 44.7 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K12287 - - - - ko00000,ko02044 - - - ESPR,IAT_beta,LRR_5,Laminin_G_3,SLH k59_181896_1 933262.AXAM01000028_gene3316 3.1e-150 435.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2MI0K@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_149516_1 1283300.ATXB01000002_gene2921 9.54e-100 308.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1XEW9@135618|Methylococcales 135618|Methylococcales C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_162482_1 1179778.PMM47T1_08506 1.39e-39 150.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_142962_1 272123.Anacy_2025 2.21e-05 53.9 COG2202@1|root,COG2203@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1GHCI@1117|Cyanobacteria,1HJUF@1161|Nostocales 1117|Cyanobacteria T Multi-sensor signal transduction histidine kinase - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9 k59_65184_2 411464.DESPIG_00504 1.02e-23 93.2 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,42TVD@68525|delta/epsilon subdivisions,2WQPX@28221|Deltaproteobacteria,2MCIY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the bacterial histone-like protein family ihfB - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_188368_1 1049564.TevJSym_aa02510 9.27e-227 634.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1J544@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_188368_2 1049564.TevJSym_aa02480 3.01e-125 367.0 COG0697@1|root,COG0697@2|Bacteria,1QQY8@1224|Proteobacteria,1RRQ6@1236|Gammaproteobacteria,1J7WK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_188368_3 1049564.TevJSym_aa02380 5.14e-68 214.0 COG2977@1|root,COG2977@2|Bacteria,1MZK2@1224|Proteobacteria,1S968@1236|Gammaproteobacteria,1J7DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Belongs to the P-Pant transferase superfamily pptA - - - - - - - - - - - ACPS k59_13352_1 643648.Slip_2357 1.88e-40 144.0 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,42JYZ@68298|Syntrophomonadaceae 186801|Clostridia S PFAM CBS domain containing protein acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_194792_1 439235.Dalk_1208 4.31e-156 459.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_182206_1 1049564.TevJSym_aa01280 1.13e-99 295.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,1S3XK@1236|Gammaproteobacteria,1J6EY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_149792_1 1163617.SCD_n01804 5.87e-233 646.0 28IVT@1|root,2Z8U5@2|Bacteria,1R7G9@1224|Proteobacteria,2W17G@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_78608_1 1049564.TevJSym_ac01160 4.78e-22 88.6 COG5416@1|root,COG5416@2|Bacteria,1NGPH@1224|Proteobacteria,1SGDB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Lipopolysaccharide assembly protein A domain - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_78608_2 1283300.ATXB01000001_gene963 4.08e-21 102.0 COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,1SCA6@1236|Gammaproteobacteria,1XFD4@135618|Methylococcales 135618|Methylococcales N PFAM Flagellar hook-length control protein - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k59_78608_4 765911.Thivi_4599 1.59e-84 256.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_143261_1 1046714.AMRX01000006_gene2748 1.41e-26 113.0 COG3203@1|root,COG3203@2|Bacteria,1Q1XX@1224|Proteobacteria,1RPIH@1236|Gammaproteobacteria,466UM@72275|Alteromonadaceae 1236|Gammaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_162794_1 1085623.GNIT_3442 2.63e-13 76.3 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,464UD@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009898,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016021,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0017004,GO:0019725,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0042221,GO:0042493,GO:0042592,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071502,GO:0071840,GO:0071944,GO:0098552,GO:0098562,GO:0140096 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - iECSE_1348.ECSE_4435 DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_104332_1 713586.KB900536_gene1209 4.72e-55 179.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,1WWR2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_117372_1 933262.AXAM01000021_gene478 1.13e-36 134.0 COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria,2MIH3@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - DUF3524,Glycos_transf_1 k59_117372_2 706587.Desti_0972 9.24e-22 94.7 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria 1224|Proteobacteria G Major facilitator Superfamily MA20_01130 - - - - - - - - - - - MFS_1 k59_110885_1 105559.Nwat_1969 9.35e-66 225.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYUH@1236|Gammaproteobacteria,1X2A1@135613|Chromatiales 135613|Chromatiales T SMART Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_156245_1 1178482.BJB45_07865 2.89e-19 88.2 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,1XH6I@135619|Oceanospirillales 135619|Oceanospirillales M Rhs family - - - - - - - - - - - - RHS,RHS_repeat,Tox-HNH-EHHH k59_20073_2 1283300.ATXB01000001_gene1819 1.04e-05 47.0 COG3630@1|root,COG3630@2|Bacteria,1NHYS@1224|Proteobacteria,1SGS8@1236|Gammaproteobacteria,1XFR3@135618|Methylococcales 135618|Methylococcales C oxaloacetate decarboxylase gamma chain oadG - 4.1.1.3 ko:K01573 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_gamma k59_20073_3 1304883.KI912532_gene2465 2.29e-26 102.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,2KW2F@206389|Rhodocyclales 206389|Rhodocyclales D Maf-like protein yceF - - ko:K06287 - - - - ko00000 - - - Maf k59_91393_1 1049564.TevJSym_bh00300 1.8e-99 299.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1J4ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_91393_2 631362.Thi970DRAFT_01572 2.65e-22 91.3 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1WZ88@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_91393_3 1118153.MOY_09595 2.47e-16 74.3 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XM7C@135619|Oceanospirillales 135619|Oceanospirillales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_59057_1 1487953.JMKF01000028_gene1283 8.44e-30 116.0 COG1974@1|root,COG1974@2|Bacteria,1G0V3@1117|Cyanobacteria,1H8XV@1150|Oscillatoriales 1117|Cyanobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_20074_1 368407.Memar_0288 1.81e-111 332.0 COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia 224756|Methanomicrobia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit atpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_46022_1 378806.STAUR_0336 1.2e-42 157.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria,2Z18Z@29|Myxococcales 28221|Deltaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_26662_1 1121405.dsmv_3405 3.18e-106 320.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_39507_1 933262.AXAM01000048_gene2593 1.57e-59 187.0 COG3807@1|root,COG3807@2|Bacteria,1RIYJ@1224|Proteobacteria,42SNK@68525|delta/epsilon subdivisions,2WPNS@28221|Deltaproteobacteria,2MK8E@213118|Desulfobacterales 28221|Deltaproteobacteria S SH3 domain - - - - - - - - - - - - SH3_4 k59_59058_1 1049564.TevJSym_aa01910 4.37e-67 206.0 COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,1S38T@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Sterol carrier protein - - - - - - - - - - - - - k59_136815_2 236097.ADG881_670 6.14e-56 181.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1XI9A@135619|Oceanospirillales 135619|Oceanospirillales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_13601_1 1173022.Cri9333_1535 3.91e-60 193.0 COG3222@1|root,COG3222@2|Bacteria,1G536@1117|Cyanobacteria,1HAJD@1150|Oscillatoriales 1117|Cyanobacteria S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_13601_2 362418.IW19_22915 2.36e-19 87.0 COG0363@1|root,COG0363@2|Bacteria,4NGB9@976|Bacteroidetes,1HY6P@117743|Flavobacteriia,2NVJY@237|Flavobacterium 976|Bacteroidetes G 6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_65510_1 177439.DP1129 2.26e-38 131.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MKFE@213118|Desulfobacterales 28221|Deltaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_65510_2 335543.Sfum_1559 2.05e-50 160.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MRYJ@213462|Syntrophobacterales 28221|Deltaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_197064_2 935845.JADQ01000007_gene1551 2.01e-86 265.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae 91061|Bacilli J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_67910_1 1049564.TevJSym_bl00090 2.8e-83 259.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1J5AS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_22632_1 1049564.TevJSym_ah00300 2.36e-109 317.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1J5Q9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_203896_1 1121405.dsmv_3221 2e-91 276.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2MI7D@213118|Desulfobacterales 28221|Deltaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_203896_2 933262.AXAM01000028_gene3300 6e-28 102.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2MKMM@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_9593_2 1167006.UWK_00817 3.02e-51 183.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MMWB@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_15446_1 1122917.KB899660_gene1741 0.000298 47.8 COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HAR9@91061|Bacilli,26SK7@186822|Paenibacillaceae 91061|Bacilli H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_15446_2 1321786.HMPREF1992_00237 4.05e-64 213.0 COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,4H26N@909932|Negativicutes 909932|Negativicutes M Glycosyltransferase group 2 family protein - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_15446_4 1276756.AUEX01000005_gene2823 6.31e-16 79.7 29DIQ@1|root,300GG@2|Bacteria,1RJVY@1224|Proteobacteria,2VTHH@28216|Betaproteobacteria,4AEF9@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3617) - - - - - - - - - - - - DUF3617 k59_15446_5 1283300.ATXB01000001_gene2146 3.82e-124 372.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RMQ0@1236|Gammaproteobacteria,1XFHJ@135618|Methylococcales 135618|Methylococcales K Aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2,GntR k59_106695_2 1049564.TevJSym_af00390 5.73e-191 535.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1J50Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdA GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0019438,GO:0019464,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045250,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0065007,GO:0065008,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385 Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_145748_1 1304885.AUEY01000034_gene1876 2.05e-42 147.0 COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,42UKY@68525|delta/epsilon subdivisions,2WR6E@28221|Deltaproteobacteria,2MPC5@213118|Desulfobacterales 28221|Deltaproteobacteria M Peptidoglycan-synthase activator LpoB - - - ko:K07337 - - - - ko00000 - - - LpoB k59_67912_1 983545.Glaag_1302 5.09e-69 225.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,465TJ@72275|Alteromonadaceae 1236|Gammaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB GO:0003674,GO:0003824,GO:0006935,GO:0008150,GO:0008984,GO:0009605,GO:0016787,GO:0016788,GO:0040011,GO:0042221,GO:0042330,GO:0050896,GO:0051723,GO:0052689,GO:0140096 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_67912_2 1049564.TevJSym_aw00450 7.7e-115 350.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J50D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0643 Chemotaxis protein histidine kinase and related kinases cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_9596_1 502025.Hoch_3218 8.27e-40 146.0 COG1451@1|root,COG1451@2|Bacteria,1P1X1@1224|Proteobacteria,4314C@68525|delta/epsilon subdivisions,2X3BB@28221|Deltaproteobacteria,2YV83@29|Myxococcales 28221|Deltaproteobacteria S nucleotide metabolic process - - - - - - - - - - - - - k59_171690_1 933262.AXAM01000022_gene3232 3.05e-100 314.0 COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,2MI3Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family qrcB - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_152109_1 1121405.dsmv_0450 1.37e-45 153.0 COG1014@1|root,COG1014@2|Bacteria,1N2W3@1224|Proteobacteria,42THX@68525|delta/epsilon subdivisions,2WQ6P@28221|Deltaproteobacteria,2MJX2@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase iorB-2 - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR k59_152109_2 1121405.dsmv_0449 1.48e-131 392.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,2MHUM@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA-2 - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_67913_1 697282.Mettu_3445 5.67e-85 263.0 COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,1RY8F@1236|Gammaproteobacteria,1XG36@135618|Methylococcales 135618|Methylococcales E 4-Hydroxyphenylpyruvate dioxygenase - - - - - - - - - - - - - k59_48398_1 1049564.TevJSym_aa02140 4.66e-132 392.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1J6IQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G MOFRL family ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_132930_5 1562701.BBOF01000023_gene715 2.68e-22 95.9 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K21K@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_132930_6 1218352.B597_020285 6.01e-75 234.0 COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria,1Z0TZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478 CobS k59_132930_7 765914.ThisiDRAFT_2629 1.03e-58 191.0 COG0406@1|root,COG0406@2|Bacteria,1MXUY@1224|Proteobacteria,1S1EF@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phosphoglycerate mutase family - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_132930_8 1049564.TevJSym_ad00630 3.73e-131 382.0 COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,1RNPV@1236|Gammaproteobacteria,1J4JU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169 DBI_PRT k59_94299_1 880072.Desac_0718 1.38e-71 231.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MRG9@213462|Syntrophobacterales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_54595_1 644282.Deba_2137 4.22e-05 45.8 COG0247@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0479@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Cysteine-rich - - - - - - - - - - - - CCG,Fer4_10,Fer4_17,Fer4_8 k59_54595_2 1166016.W5S_0240 3.55e-70 233.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1MQRJ@122277|Pectobacterium 1236|Gammaproteobacteria F bifunctional purine biosynthesis protein PurH purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_94304_1 204669.Acid345_1776 5.79e-20 94.4 COG2203@1|root,COG3829@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,RsbRD_N k59_113205_4 1249627.D779_4079 1.28e-95 285.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1WWM4@135613|Chromatiales 135613|Chromatiales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_73957_1 765913.ThidrDRAFT_2347 2.5e-27 105.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_73957_2 887898.HMPREF0551_2530 3.31e-35 138.0 COG0079@1|root,COG0141@1|root,COG0079@2|Bacteria,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,1JZTN@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_120140_1 765913.ThidrDRAFT_0838 1.23e-286 807.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WXBA@135613|Chromatiales 135613|Chromatiales G PEP-utilising enzyme, mobile - - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 k59_120140_2 270374.MELB17_21330 3.53e-07 49.3 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,46851@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3436 Transposase and inactivated derivatives - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_126729_1 1165841.SULAR_02878 9.41e-92 283.0 COG3211@1|root,COG3211@2|Bacteria,1NSHF@1224|Proteobacteria 1224|Proteobacteria S Phosphatase - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_22644_1 396588.Tgr7_0948 6.35e-36 133.0 COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,1T20G@1236|Gammaproteobacteria 1236|Gammaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_22644_2 519989.ECTPHS_10971 6.62e-193 545.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_158607_1 1049564.TevJSym_ae00460 1.99e-143 412.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria 1224|Proteobacteria C radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_28994_1 335543.Sfum_1824 5.24e-43 147.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42R5Z@68525|delta/epsilon subdivisions,2WMPN@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_61682_1 177437.HRM2_15730 3.74e-62 209.0 COG2203@1|root,COG4191@1|root,COG5000@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1R3RN@1224|Proteobacteria,42P11@68525|delta/epsilon subdivisions,2WJEK@28221|Deltaproteobacteria,2MN0A@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,HAMP,HATPase_c,PAS_4 k59_152238_1 754477.Q7C_1790 2.98e-106 333.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales 72273|Thiotrichales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_42632_1 1049564.TevJSym_ai00210 1.13e-110 335.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_178375_1 1049564.TevJSym_ak00860 3.4e-72 227.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1J55A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Arabinose 5-phosphate isomerase kdsD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4519,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iPC815.YPO3577,iSFV_1184.SFV_3227,iSFxv_1172.SFxv_3550,iYL1228.KPN_03607,iZ_1308.Z4560 CBS,SIS k59_178375_2 1049564.TevJSym_ak00870 3.57e-128 374.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1J4U9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P antiporter yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_100026_1 439235.Dalk_1014 3.01e-76 234.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria,2MJ93@213118|Desulfobacterales 28221|Deltaproteobacteria N PFAM MotA TolQ ExbB proton channel - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_9773_1 1177181.T9A_01434 1.02e-69 237.0 COG2303@1|root,COG2303@2|Bacteria,1QQ8F@1224|Proteobacteria,1SX7Q@1236|Gammaproteobacteria,1XP0Z@135619|Oceanospirillales 135619|Oceanospirillales E GMC oxidoreductase - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_42634_1 316067.Geob_3364 4.29e-66 206.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,43USN@69541|Desulfuromonadales 28221|Deltaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_197222_1 367336.OM2255_03562 3.68e-08 58.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_145909_1 1049564.TevJSym_ad00650 1.84e-93 288.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,1RP8G@1236|Gammaproteobacteria,1J5NJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_113337_1 2340.JV46_22160 1.09e-103 315.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1J4FJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0018995,GO:0022610,GO:0030430,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0050789,GO:0051082,GO:0051704,GO:0061077,GO:0065007,GO:0101031,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_185041_1 1499967.BAYZ01000009_gene5391 2.5e-90 286.0 COG2766@1|root,COG2766@2|Bacteria 2|Bacteria T protein kinase activity - - - - - - - - - - - - AAA_PrkA,PrkA k59_138940_1 1049564.TevJSym_av00380 6.77e-129 379.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1J7ED@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG1459 Type II secretory pathway, component PulF lspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_138940_2 1049564.TevJSym_av00390 2.94e-31 114.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_35770_1 1049564.TevJSym_bi00330 8.25e-294 828.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1J4WG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_178380_1 1265505.ATUG01000001_gene4456 1.16e-27 106.0 COG1633@1|root,COG1633@2|Bacteria,1N36M@1224|Proteobacteria,42UVX@68525|delta/epsilon subdivisions,2WQ53@28221|Deltaproteobacteria,2MMYP@213118|Desulfobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_178380_2 644282.Deba_1038 8.45e-30 118.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_29006_1 177437.HRM2_44350 4.14e-09 56.6 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein) - - - - - - - - - - - - rve k59_29006_2 177437.HRM2_48310 4.12e-52 167.0 2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria,2MMAB@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_106874_1 547042.BACCOPRO_01514 3.23e-23 101.0 COG0704@1|root,COG0704@2|Bacteria,4NNT5@976|Bacteroidetes,2FNP4@200643|Bacteroidia,4AM4G@815|Bacteroidaceae 976|Bacteroidetes P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_204060_1 439235.Dalk_1106 1.15e-18 89.7 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,42NJB@68525|delta/epsilon subdivisions,2WM62@28221|Deltaproteobacteria,2MI1G@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2333) - - - - - - - - - - - - DUF2333 k59_120281_1 933262.AXAM01000014_gene278 1.6e-46 170.0 COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X8IN@28221|Deltaproteobacteria,2MPP7@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_197227_1 933262.AXAM01000001_gene337 1.33e-88 267.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MJ4H@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_165099_1 314256.OG2516_13009 1.74e-17 86.3 COG1172@1|root,COG1172@2|Bacteria,1NB7E@1224|Proteobacteria,2U0TT@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Ribose xylose arabinose galactoside ABC-type transport systems permease components - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_94534_2 765910.MARPU_13435 5.88e-50 164.0 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,1S20Q@1236|Gammaproteobacteria,1WY8G@135613|Chromatiales 135613|Chromatiales L pfam nudix - - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_94534_4 1049564.TevJSym_be00260 6.54e-128 372.0 COG1443@1|root,COG1443@2|Bacteria,1QXSY@1224|Proteobacteria,1RPX8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I pfam nudix - - - - - - - - - - - - DUF4743,NUDIX k59_138949_1 1322246.BN4_20408 0.000947 42.7 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2M87I@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_138949_2 429009.Adeg_1431 1.27e-30 113.0 COG1145@1|root,COG1145@2|Bacteria,1UJS9@1239|Firmicutes,25F8M@186801|Clostridia,42GXW@68295|Thermoanaerobacterales 186801|Clostridia C NIL - - - - - - - - - - - - Fer4,NIL k59_133071_1 562743.JH976438_gene2178 0.000117 49.3 COG1376@1|root,COG1376@2|Bacteria,1V9XU@1239|Firmicutes,4HKDD@91061|Bacilli 91061|Bacilli M ErfK YbiS YcfS YnhG family protein ykuD - - - - - - - - - - - LysM,YkuD k59_191200_1 1168065.DOK_11102 4e-149 435.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Type I restriction-modification system methyltransferase subunit hsdM GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_191200_2 1028800.RG540_PA14910 2.76e-75 234.0 COG4849@1|root,COG4849@2|Bacteria,1RDHG@1224|Proteobacteria,2U2NW@28211|Alphaproteobacteria,4BIQE@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_191200_3 883078.HMPREF9695_02501 8.5e-63 200.0 28W7P@1|root,2ZI89@2|Bacteria,1N2SJ@1224|Proteobacteria,2U8WQ@28211|Alphaproteobacteria,3K5RK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_191200_4 32042.PstZobell_14207 0.0 1578.0 COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,1Z0HH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases hsdR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF4145,EcoEI_R_C,HSDR_N,Helicase_C,ResIII k59_166519_1 1121434.AULY01000008_gene261 8.05e-29 120.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2M7ZN@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_153695_1 1304883.KI912532_gene998 3.54e-36 130.0 COG0619@1|root,COG0619@2|Bacteria,1R4KM@1224|Proteobacteria,2VQX3@28216|Betaproteobacteria,2KXCM@206389|Rhodocyclales 206389|Rhodocyclales P Cobalt transport protein - - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_153695_2 1304883.KI912532_gene997 4.85e-129 374.0 COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,2VPJD@28216|Betaproteobacteria,2KWCB@206389|Rhodocyclales 206389|Rhodocyclales P Part of an ABC transporter complex. Responsible for energy coupling to the transport system - - - ko:K02006 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran k59_153695_3 159087.Daro_1693 2.96e-137 392.0 COG2875@1|root,COG2875@2|Bacteria,1MVYY@1224|Proteobacteria,2VHWE@28216|Betaproteobacteria,2KUT3@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the precorrin methyltransferase family - - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_134548_1 1121405.dsmv_0664 3.97e-107 318.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_30617_1 1232410.KI421425_gene1550 8.52e-97 301.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_4146_1 1123288.SOV_5c03850 8.65e-53 184.0 COG1260@1|root,COG1260@2|Bacteria,1UY87@1239|Firmicutes 1239|Firmicutes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 k59_140622_1 999141.GME_09484 9.74e-20 85.9 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1XIQH@135619|Oceanospirillales 135619|Oceanospirillales E ABC transporter ATP-binding protein - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_140622_2 323261.Noc_1640 1.02e-40 142.0 COG0569@1|root,COG0569@2|Bacteria,1RDDX@1224|Proteobacteria,1S3ZR@1236|Gammaproteobacteria,1WY9A@135613|Chromatiales 135613|Chromatiales C TrkA-N domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_128726_1 880070.Cycma_2642 3.46e-14 76.6 COG0860@1|root,COG0860@2|Bacteria,4NGKC@976|Bacteroidetes,47M2P@768503|Cytophagia 976|Bacteroidetes M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_172856_1 247490.KSU1_A0020 1.18e-50 182.0 COG0761@1|root,COG0761@2|Bacteria,2IXK4@203682|Planctomycetes 203682|Planctomycetes IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB,UbiA k59_179918_1 933262.AXAM01000022_gene3232 6.23e-20 87.8 COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,2MI3Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family qrcB - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_179918_2 933262.AXAM01000022_gene3231 4.16e-57 184.0 COG3474@1|root,COG3474@2|Bacteria,1QUNA@1224|Proteobacteria,42PVG@68525|delta/epsilon subdivisions,2WJ7N@28221|Deltaproteobacteria,2MIQK@213118|Desulfobacterales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrom_CIII,Cytochrome_C7 k59_147419_1 379066.GAU_3726 1.22e-28 114.0 COG3666@1|root,COG3666@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_205492_1 933262.AXAM01000104_gene1071 1.31e-134 392.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42PEQ@68525|delta/epsilon subdivisions,2WKWX@28221|Deltaproteobacteria,2MHQR@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - - - - - - - - - - HGD-D k59_17193_1 933262.AXAM01000032_gene687 1.99e-76 234.0 COG2974@1|root,COG2974@2|Bacteria,1N4GC@1224|Proteobacteria,42RPT@68525|delta/epsilon subdivisions,2WQUM@28221|Deltaproteobacteria,2MJSD@213118|Desulfobacterales 28221|Deltaproteobacteria L Putative exonuclease, RdgC - - - - - - - - - - - - RdgC k59_101605_1 933262.AXAM01000001_gene445 1.8e-75 253.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2MHQJ@213118|Desulfobacterales 28221|Deltaproteobacteria OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_50182_1 472759.Nhal_1236 8.94e-45 165.0 COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1X2NT@135613|Chromatiales 135613|Chromatiales S TIGRFAM hopanoid biosynthesis associated RND transporter like protein HpnN - - - ko:K07003 - - - - ko00000 - - - MMPL k59_134715_1 338963.Pcar_0794 1.46e-47 164.0 COG1479@1|root,COG1479@2|Bacteria,1R63V@1224|Proteobacteria,42QDT@68525|delta/epsilon subdivisions,2WQZH@28221|Deltaproteobacteria,43VUH@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function DUF262 - - - - - - - - - - - - DUF262 k59_134715_2 338963.Pcar_0795 2.14e-91 273.0 2CUGC@1|root,33KWR@2|Bacteria,1NKUD@1224|Proteobacteria,433NG@68525|delta/epsilon subdivisions,2WY34@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_37665_1 387093.SUN_1729 1.03e-82 246.0 COG1943@1|root,COG1943@2|Bacteria,1RF1K@1224|Proteobacteria,42VRT@68525|delta/epsilon subdivisions,2YQZ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COGs COG1943 Transposase and inactivated derivatives - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_63567_1 880072.Desac_0331 2.46e-118 353.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2MRHH@213462|Syntrophobacterales 28221|Deltaproteobacteria H Pyridoxal-phosphate dependent enzyme thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_4299_1 861299.J421_3883 2.05e-69 233.0 COG1429@1|root,COG1429@2|Bacteria 2|Bacteria H ligase activity, forming nitrogen-metal bonds cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel,Glyco_hydro_63 k59_96551_2 1178482.BJB45_20480 1.21e-58 191.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1XJ8Z@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_96551_3 1049564.TevJSym_aq00380 9.59e-115 335.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1J5A9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D ATPases involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_75802_1 177437.HRM2_36780 2.03e-67 221.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_89136_2 933262.AXAM01000073_gene3359 2.06e-58 189.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,2MI5J@213118|Desulfobacterales 28221|Deltaproteobacteria F CobB/CobQ-like glutamine amidotransferase domain purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_63568_2 335543.Sfum_1305 1.66e-29 116.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,42NZ8@68525|delta/epsilon subdivisions,2WK0Y@28221|Deltaproteobacteria,2MQIM@213462|Syntrophobacterales 28221|Deltaproteobacteria M Beta-lactamase enzyme family - - 3.4.16.4 ko:K07258,ko:K07262 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_24646_1 931276.Cspa_c52660 1.09e-108 327.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,36GDB@31979|Clostridiaceae 186801|Clostridia L PFAM transposase, mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_44968_1 1049564.TevJSym_ac01350 1.5e-63 203.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1J4TV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - APH k59_153833_1 448385.sce6293 6.2e-40 153.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,43BZX@68525|delta/epsilon subdivisions,2X7AP@28221|Deltaproteobacteria,2YXNP@29|Myxococcales 28221|Deltaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp k59_63570_1 439235.Dalk_1457 5.58e-39 146.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,2MHZ5@213118|Desulfobacterales 28221|Deltaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_172972_2 218491.ECA2492 6.53e-28 108.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1MRKM@122277|Pectobacterium 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_82841_1 1249627.D779_1625 3.15e-24 98.6 COG0310@1|root,COG0310@2|Bacteria,1RJRC@1224|Proteobacteria,1S6H0@1236|Gammaproteobacteria,1WX9R@135613|Chromatiales 135613|Chromatiales P PFAM Cobalt uptake substrate-specific transmembrane region - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_82841_2 765912.Thimo_0930 2.73e-43 150.0 COG0310@1|root,COG0310@2|Bacteria,1RIKP@1224|Proteobacteria,1T2DN@1236|Gammaproteobacteria,1WYPH@135613|Chromatiales 135613|Chromatiales P cobalt ion transport - - - ko:K16915 ko02010,map02010 M00246 - - ko00000,ko00001,ko00002,ko02000 - - - - k59_82841_3 641491.DND132_0335 2.66e-20 91.3 COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,42RU5@68525|delta/epsilon subdivisions,2WNB7@28221|Deltaproteobacteria,2MA26@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ cbiQ - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_17305_1 1121403.AUCV01000038_gene4226 1.63e-93 285.0 COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria 1224|Proteobacteria C atp synthase - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_17305_2 1121403.AUCV01000038_gene4227 2.16e-261 727.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,42NDR@68525|delta/epsilon subdivisions,2WJQ4@28221|Deltaproteobacteria 1224|Proteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA1 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_17305_3 522306.CAP2UW1_2681 6.74e-54 181.0 COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,1R6C0@1224|Proteobacteria,2VNRP@28216|Betaproteobacteria 28216|Betaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,DUF2934,OSCP k59_17305_4 1288826.MSNKSG1_00536 9.83e-39 130.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_17305_5 1121403.AUCV01000038_gene4230 2.78e-107 315.0 COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria 1224|Proteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_17305_6 1121403.AUCV01000038_gene4231 5.94e-34 119.0 2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria 1224|Proteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_17305_7 1121403.AUCV01000038_gene4232 9.26e-42 142.0 COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria 1224|Proteobacteria C atp synthase atpC_2 - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_17305_8 1415778.JQMM01000001_gene2175 5.66e-277 764.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1J56Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits - - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_115004_1 398767.Glov_2384 3.8e-21 94.4 2ATWF@1|root,31JFP@2|Bacteria,1RK55@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_37674_1 225937.HP15_1070 4.29e-49 179.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,469RS@72275|Alteromonadaceae 1236|Gammaproteobacteria S transport system, fused permease components - - - - - - - - - - - - DUF3394,DctM k59_50351_1 1499967.BAYZ01000154_gene1502 1.82e-39 148.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_186994_2 1007105.PT7_2199 1.86e-47 166.0 COG3935@1|root,COG3935@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DnaB_2 k59_186994_3 999141.GME_00982 3.55e-30 108.0 2EE35@1|root,334GI@2|Bacteria,1NCEI@1224|Proteobacteria,1T0V0@1236|Gammaproteobacteria,1XQXD@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_122437_1 485913.Krac_5503 1.43e-67 216.0 COG1484@1|root,COG1484@2|Bacteria,2G951@200795|Chloroflexi 200795|Chloroflexi L SPTR A5GDR9 IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_122437_2 879212.DespoDRAFT_01154 3.57e-117 360.0 COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria,2MQ06@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Integrase core domain - - - - - - - - - - - - rve k59_44976_1 706587.Desti_0451 1.27e-16 87.4 COG0784@1|root,COG3437@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_8,PAS_9,PocR,Response_reg k59_166714_2 1049564.TevJSym_ae00860 2.23e-38 133.0 COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,1S8J5@1236|Gammaproteobacteria,1JAXC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Domain of unknown function (DUF1924) shp - - - - - - - - - - - DUF1924 k59_115005_1 1049564.TevJSym_aa00670 1.22e-285 805.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1J4ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_89145_1 713586.KB900536_gene2860 4.79e-11 62.8 COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria 2|Bacteria S response to heat - - - ko:K06149,ko:K07090 - - - - ko00000 - - - TauE,Usp k59_89145_2 596151.DesfrDRAFT_0967 1.24e-17 82.4 2EGXE@1|root,33APK@2|Bacteria,1N7CV@1224|Proteobacteria,42WGR@68525|delta/epsilon subdivisions,2WRN7@28221|Deltaproteobacteria,2MD4M@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_147616_1 631362.Thi970DRAFT_04602 2.19e-42 151.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,1WXVB@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_147616_2 768671.ThimaDRAFT_0805 1.54e-21 93.2 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWSZ@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_198838_2 1121405.dsmv_0405 4.76e-55 187.0 COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,42RFD@68525|delta/epsilon subdivisions 1224|Proteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA2 - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_122444_1 321327.CYA_0822 2.71e-31 118.0 COG0164@1|root,COG0164@2|Bacteria,1G507@1117|Cyanobacteria,1H0B0@1129|Synechococcus 1117|Cyanobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_180048_2 765910.MARPU_00740 3.01e-132 380.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RSQ8@1236|Gammaproteobacteria,1WWKV@135613|Chromatiales 135613|Chromatiales C TIGRFAM Succinate dehydrogenase fumarate reductase iron-sulphur protein - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_180048_3 1049564.TevJSym_ah01000 2.57e-209 598.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1J4I0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_101777_1 526222.Desal_3560 6.35e-72 226.0 COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,42NEK@68525|delta/epsilon subdivisions,2WJPT@28221|Deltaproteobacteria,2M87E@213115|Desulfovibrionales 28221|Deltaproteobacteria S Dienelactone hydrolase family - - - ko:K06889 - - - - ko00000 - - - DLH,Peptidase_S15 k59_108887_1 472759.Nhal_2382 1.74e-117 355.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales 135613|Chromatiales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_70217_1 99598.Cal7507_3737 9.01e-100 317.0 COG3299@1|root,COG3299@2|Bacteria,1G3VV@1117|Cyanobacteria 1117|Cyanobacteria S protein, phage tail-like region - - - - - - - - - - - - Baseplate_J k59_63595_1 1121451.DESAM_22094 2.62e-90 296.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MXI@68525|delta/epsilon subdivisions,2X222@28221|Deltaproteobacteria,2M8BY@213115|Desulfovibrionales 28221|Deltaproteobacteria T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PAS_4,dCache_1 k59_37691_1 323848.Nmul_A1913 1.92e-07 51.2 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,372EG@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_37691_2 1123504.JQKD01000008_gene5452 8.14e-18 81.6 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,4ABED@80864|Comamonadaceae 28216|Betaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_205676_1 1121451.DESAM_21564 4.29e-59 206.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MG2T@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_17324_1 713586.KB900536_gene2120 2.05e-115 348.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales 135613|Chromatiales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_195444_4 315749.Bcer98_2619 1.03e-47 169.0 COG5377@1|root,COG5377@2|Bacteria,1TS2Y@1239|Firmicutes,4HAFK@91061|Bacilli,1ZBMA@1386|Bacillus 91061|Bacilli L YqaJ-like viral recombinase domain yqaJ - - - - - - - - - - - YqaJ k59_195444_5 343516.Q286Y0_9CAUD 1.9e-34 131.0 4QBP3@10239|Viruses,4QVAZ@35237|dsDNA viruses no RNA stage,4QPEQ@28883|Caudovirales,4QNVM@10744|Podoviridae 10744|Podoviridae S PDDEXK-like domain of unknown function (DUF3799) - - - - - - - - - - - - - k59_163281_1 1122619.KB892368_gene2390 8.98e-23 97.8 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,3T2EC@506|Alcaligenaceae 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_40180_1 1353537.TP2_00220 7.48e-57 191.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,2XP7H@285107|Thioclava 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hupL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_40180_2 1249627.D779_1538 3.45e-75 234.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1WWYJ@135613|Chromatiales 135613|Chromatiales C Hydrogenase (NiFe) small subunit HydA - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_33640_1 1304885.AUEY01000002_gene330 2.16e-39 140.0 COG1418@1|root,COG1418@2|Bacteria,1RGCM@1224|Proteobacteria,42RC5@68525|delta/epsilon subdivisions,2WNBA@28221|Deltaproteobacteria,2MJS4@213118|Desulfobacterales 28221|Deltaproteobacteria S mRNA catabolic process - - - - - - - - - - - - HD k59_85461_1 32057.KB217478_gene7447 7.6e-117 343.0 COG0667@1|root,COG0667@2|Bacteria,1G2QT@1117|Cyanobacteria,1HRA6@1161|Nostocales 1117|Cyanobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_189288_1 1049564.TevJSym_bl00220 1.16e-79 254.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_79260_1 1049564.TevJSym_aw00450 2.57e-94 297.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J50D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0643 Chemotaxis protein histidine kinase and related kinases cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_20629_1 690850.Desaf_1699 1.73e-47 172.0 COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2M9TK@213115|Desulfovibrionales 28221|Deltaproteobacteria C Fe-S cluster domain protein - - - - - - - - - - - - FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_143928_1 911045.PSE_3362 4.68e-19 88.6 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_32,rve,rve_3 k59_156816_1 1049564.TevJSym_at00590 1.48e-73 239.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1J4RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_118065_1 247633.GP2143_07864 2.12e-53 184.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1J4K9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_137262_1 1385935.N836_16225 1.23e-103 303.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_150475_1 1049564.TevJSym_ah00830 1.02e-236 674.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1J4U2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_150475_2 1121374.KB891585_gene1832 4.95e-15 82.4 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_176244_1 472759.Nhal_3413 7.3e-102 301.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X250@135613|Chromatiales 135613|Chromatiales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_33691_1 1249627.D779_0425 3.21e-38 128.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,1WYXU@135613|Chromatiales 135613|Chromatiales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_33691_2 1049564.TevJSym_ac00870 1.2e-72 221.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1J6EF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_33691_3 1049564.TevJSym_ac00860 1.67e-10 61.2 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_92024_1 1121405.dsmv_0504 4.1e-83 261.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria,2MIV1@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_104894_1 1121422.AUMW01000010_gene1084 8.19e-23 101.0 COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,267CA@186807|Peptococcaceae 186801|Clostridia C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_59655_1 1232437.KL662073_gene1725 1.36e-159 467.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_66021_1 670292.JH26_00425 2.87e-83 256.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_3 k59_202312_1 1415780.JPOG01000001_gene1953 5.79e-188 566.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales 1236|Gammaproteobacteria T Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_202312_2 1122134.KB893650_gene432 6.09e-53 175.0 COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria,1S8SN@1236|Gammaproteobacteria 1236|Gammaproteobacteria K regulatory protein TetR - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_202312_3 1049564.TevJSym_av00120 7.08e-187 531.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1J4HM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,GATase_7,Pribosyltran k59_131086_1 672.VV93_v1c25250 4.27e-44 151.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1XTAS@135623|Vibrionales 135623|Vibrionales I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050518,GO:0070567,GO:0071704,GO:1901576 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_131086_2 1042375.AFPL01000031_gene741 2.01e-14 68.6 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,46898@72275|Alteromonadaceae 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301 - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_59658_1 909663.KI867150_gene1321 9.08e-67 214.0 COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales 28221|Deltaproteobacteria KQ Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_20695_1 311424.DhcVS_792 4.55e-193 545.0 COG1900@1|root,COG1900@2|Bacteria,2GASV@200795|Chloroflexi,34DA0@301297|Dehalococcoidia 301297|Dehalococcoidia S Homocysteine biosynthesis enzyme, sulfur-incorporation - - - - - - - - - - - - HcyBio k59_137270_1 1121403.AUCV01000040_gene4305 6.18e-32 118.0 COG1785@1|root,COG1785@2|Bacteria,1P3CS@1224|Proteobacteria 1224|Proteobacteria P Alkaline phosphatase - - - - - - - - - - - - Alk_phosphatase k59_163332_1 261292.Nit79A3_3318 3.6e-25 121.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VMY9@28216|Betaproteobacteria,371V4@32003|Nitrosomonadales 28216|Betaproteobacteria M Insecticidal toxin complex protein TcaC - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS k59_104897_2 1122915.AUGY01000015_gene2623 7.27e-16 83.6 COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,26QDE@186822|Paenibacillaceae 91061|Bacilli EGP major facilitator superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_3,Sugar_tr k59_182912_1 340177.Cag_0028 7.86e-09 61.6 COG0760@1|root,COG0760@2|Bacteria,1FDC8@1090|Chlorobi 1090|Chlorobi M PFAM PpiC-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N,SurA_N_3 k59_182912_2 459495.SPLC1_S240820 4.04e-08 61.6 COG4783@1|root,COG4783@2|Bacteria,1G1TE@1117|Cyanobacteria,1H9TK@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_182912_3 998674.ATTE01000001_gene213 7.95e-59 186.0 COG0393@1|root,COG0393@2|Bacteria,1N6BK@1224|Proteobacteria,1SAFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_182912_4 998674.ATTE01000001_gene212 2.29e-53 169.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1T189@1236|Gammaproteobacteria,463TY@72273|Thiotrichales 72273|Thiotrichales S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 k59_182912_5 1049564.TevJSym_ap00360 5.19e-233 650.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1J4EQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_182912_6 207954.MED92_11939 9.25e-18 77.4 COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,1SCN4@1236|Gammaproteobacteria,1XM9P@135619|Oceanospirillales 135619|Oceanospirillales S Iron-binding zinc finger CDGSH type - - - - - - - - - - - - zf-CDGSH k59_1090_1 1192034.CAP_0838 2.67e-19 86.7 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJBM@28221|Deltaproteobacteria,2YTUN@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_1090_2 1280954.HPO_03714 3.55e-168 494.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,43W4P@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_53094_2 398767.Glov_3085 3.25e-40 170.0 28JHJ@1|root,2Z9B3@2|Bacteria,1NXYE@1224|Proteobacteria,430WY@68525|delta/epsilon subdivisions,2WVTK@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_53094_3 1410638.JHXJ01000008_gene373 9.87e-07 57.0 COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia,3WPTX@541000|Ruminococcaceae 186801|Clostridia S Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_25 k59_53094_4 95619.PM1_0204575 2.34e-49 174.0 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,1S4C3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the LOG family yvdD - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_53094_7 1123229.AUBC01000006_gene1017 7.4e-33 139.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TUPK@28211|Alphaproteobacteria,3JVM0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Mg-protoporphyrin IX monomethyl ester oxidative cyclase 66kD subunit bchE - 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,Fer4_12,Radical_SAM k59_46595_1 357804.Ping_0433 1.47e-85 275.0 COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,1T0KQ@1236|Gammaproteobacteria,2QHBY@267894|Psychromonadaceae 1236|Gammaproteobacteria S Heparinase II/III N-terminus - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_59660_1 1163617.SCD_n02256 9.45e-16 77.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase type 11 - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_59660_2 1191523.MROS_0495 4.69e-24 96.3 COG0053@1|root,COG0053@2|Bacteria 2|Bacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - 2.5.1.105 ko:K04088,ko:K06897 ko00790,map00790 M00742 R10339 RC00121 ko00000,ko00001,ko00002,ko01000 - - - Cation_efflux k59_150489_1 933262.AXAM01000015_gene85 3.56e-69 218.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2MHYU@213118|Desulfobacterales 28221|Deltaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_150489_2 933262.AXAM01000015_gene86 1.77e-26 103.0 COG0632@1|root,COG0632@2|Bacteria,1Q5HB@1224|Proteobacteria,42R4Y@68525|delta/epsilon subdivisions,2WMRB@28221|Deltaproteobacteria,2MJPI@213118|Desulfobacterales 28221|Deltaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_N k59_20698_1 768671.ThimaDRAFT_0282 1.02e-205 574.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales 135613|Chromatiales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_202316_1 481448.Minf_1829 8.08e-39 135.0 COG1182@1|root,COG1182@2|Bacteria,46T2N@74201|Verrucomicrobia,37H4R@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity acpD - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_176259_1 1049564.TevJSym_ai00140 7.77e-22 89.4 COG0242@1|root,COG0242@2|Bacteria,1QM3A@1224|Proteobacteria,1RZHN@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_176259_2 1123519.PSJM300_11540 8.05e-62 196.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1Z04D@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_124513_1 2340.JV46_21960 4.44e-37 139.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_124513_5 1401065.HMPREF2130_10730 2.49e-78 241.0 28HX7@1|root,2Z82Y@2|Bacteria,1R7X5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_124513_6 1401065.HMPREF2130_10735 1.35e-43 148.0 28NZB@1|root,2ZBW9@2|Bacteria,1RB60@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_124513_7 614083.AWQR01000040_gene772 3.97e-41 148.0 2CJ8Z@1|root,32WUG@2|Bacteria,1N1PS@1224|Proteobacteria,2VUYW@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_124513_9 272630.MexAM1_META1p3131 3.41e-67 216.0 COG1120@1|root,COG1120@2|Bacteria,1QPWJ@1224|Proteobacteria,2U1TK@28211|Alphaproteobacteria,1JTP0@119045|Methylobacteriaceae 28211|Alphaproteobacteria HP ABC transporter fecE - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_124513_10 323098.Nwi_3048 4.23e-08 54.3 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,3JWF5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_118085_1 1049564.TevJSym_ao00210 2.37e-63 196.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1J6H8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_163337_1 1324957.K933_16552 4.37e-15 81.3 COG3291@1|root,COG3979@1|root,arCOG02499@1|root,arCOG07560@1|root,arCOG02499@2157|Archaea,arCOG02508@2157|Archaea,arCOG07560@2157|Archaea,arCOG07581@2157|Archaea,2Y80Y@28890|Euryarchaeota,24124@183963|Halobacteria 183963|Halobacteria G COG3291 FOG PKD repeat - - - - - - - - - - - - PKD k59_59662_1 344747.PM8797T_20458 3.71e-55 184.0 COG0500@1|root,COG2226@2|Bacteria,2IXEP@203682|Planctomycetes 203682|Planctomycetes Q O-methyltransferase - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_53098_1 379066.GAU_3726 4.51e-24 100.0 COG3666@1|root,COG3666@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_27264_1 1049564.TevJSym_ah00500 3.62e-99 304.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1JBY1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_27264_2 76114.ebA5408 4.42e-60 190.0 COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KWDI@206389|Rhodocyclales 206389|Rhodocyclales S ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_27264_3 472759.Nhal_2856 3.04e-14 71.2 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_131098_1 1340493.JNIF01000003_gene2060 7.67e-69 234.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_20702_1 1121439.dsat_1401 8.78e-93 275.0 COG0243@1|root,COG0243@2|Bacteria,1MWPS@1224|Proteobacteria,42QIW@68525|delta/epsilon subdivisions,2WJPY@28221|Deltaproteobacteria,2MB0B@213115|Desulfovibrionales 28221|Deltaproteobacteria C molybdopterin oxidoreductase Fe4S4 - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,TAT_signal k59_195497_2 1318628.MARLIPOL_18308 7.09e-17 75.1 COG3609@1|root,COG3609@2|Bacteria,1NH8E@1224|Proteobacteria,1SYB0@1236|Gammaproteobacteria 1224|Proteobacteria K transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - ko:K07746 - - - - ko00000,ko02048 - - - ParD_antitoxin k59_195497_3 1056820.KB900654_gene3144 5.45e-46 159.0 COG4974@1|root,COG4974@2|Bacteria,1PZTE@1224|Proteobacteria,1RPTV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_131099_1 85643.Tmz1t_3538 2.43e-11 68.6 COG0845@1|root,COG0845@2|Bacteria,1RG7M@1224|Proteobacteria,2VTUZ@28216|Betaproteobacteria,2KY2N@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_118086_1 1121022.ABENE_15475 4.08e-44 150.0 2DHFK@1|root,32U96@2|Bacteria,1N6CG@1224|Proteobacteria,2UGMD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_169970_1 1502770.JQMG01000001_gene493 1.53e-159 464.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,2KMDP@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_169970_2 1121439.dsat_0258 4.7e-70 227.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2M7UU@213115|Desulfovibrionales 28221|Deltaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_169970_3 1004785.AMBLS11_03325 6.6e-140 422.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,46445@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_59667_1 247633.GP2143_04303 1.45e-71 237.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1J4T3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorB yfjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_73776_2 1049564.TevJSym_be00270 3.08e-53 186.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_178013_1 1249627.D779_1251 1.96e-52 171.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales 135613|Chromatiales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_178013_2 580332.Slit_2006 1.1e-05 55.8 COG0515@1|root,COG1639@1|root,COG2203@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,COG2203@2|Bacteria,1NJC4@1224|Proteobacteria,2VHRZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Metal-dependent hydrolase HDOD - - - - - - - - - - - - GAF_2,HDOD,Pkinase k59_164740_1 96561.Dole_0821 1.26e-23 98.2 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,42MJQ@68525|delta/epsilon subdivisions,2WTID@28221|Deltaproteobacteria,2MMFR@213118|Desulfobacterales 28221|Deltaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_94029_1 1120963.KB894500_gene116 2.6e-70 237.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RWPE@1236|Gammaproteobacteria,2Q1SY@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - 7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,Response_reg k59_138635_1 765912.Thimo_1097 2.81e-97 295.0 COG0460@1|root,COG2716@1|root,COG0460@2|Bacteria,COG2716@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_171556_2 1144343.PMI41_03108 3.39e-29 120.0 COG0477@1|root,COG0477@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily ycaD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08219 - - - - ko00000,ko02000 2.A.1.26 - - MFS_1,Sugar_tr k59_73779_1 1232437.KL662020_gene705 3.16e-29 115.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_42198_3 870187.Thini_3823 2.57e-190 553.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase k59_42198_4 1121939.L861_12595 3.02e-35 123.0 COG2329@1|root,COG2329@2|Bacteria,1QCV7@1224|Proteobacteria,1SDHZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_42198_6 580332.Slit_0877 1.5e-07 52.8 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,2VM9W@28216|Betaproteobacteria 28216|Betaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_196846_2 420662.Mpe_A1209 1.15e-41 143.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,1KM3E@119065|unclassified Burkholderiales 28216|Betaproteobacteria P subunit of a heme lyase ccmH - - ko:K02200 - - - - ko00000 - - - CcmH k59_184660_2 243265.plu3254 4.58e-21 88.6 COG3157@1|root,COG3157@2|Bacteria,1N1FT@1224|Proteobacteria,1RQRH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type VI secretion system effector hcp3 - - ko:K11903 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - T6SS_HCP k59_184660_3 1117314.PCIT_04285 6.15e-24 95.1 2905F@1|root,2ZMVB@2|Bacteria,1P5M8@1224|Proteobacteria,1SWC1@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_184660_5 795666.MW7_0998 5.58e-68 224.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,2VIPB@28216|Betaproteobacteria,1K5WQ@119060|Burkholderiaceae 28216|Betaproteobacteria S terminase GpA - - - - - - - - - - - - Terminase_GpA k59_94032_1 1049564.TevJSym_ag00090 1.34e-107 312.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_42200_1 223926.28808486 7.83e-06 51.6 COG3015@1|root,COG3015@2|Bacteria,1N97X@1224|Proteobacteria,1SEMN@1236|Gammaproteobacteria,1XXAR@135623|Vibrionales 135623|Vibrionales MP lipoprotein NlpE involved in copper resistance - - - - - - - - - - - - NlpE k59_80806_1 335543.Sfum_3688 2.83e-124 365.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42YGX@68525|delta/epsilon subdivisions,2WTHT@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_203739_1 179408.Osc7112_2555 2.32e-102 300.0 COG1335@1|root,COG1335@2|Bacteria,1G3QK@1117|Cyanobacteria,1HEG7@1150|Oscillatoriales 1117|Cyanobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_178024_1 1121918.ARWE01000001_gene3027 5.48e-40 136.0 2FDAJ@1|root,345CF@2|Bacteria,1P36N@1224|Proteobacteria,4314V@68525|delta/epsilon subdivisions,2WX3M@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_9374_1 338966.Ppro_0721 3.26e-58 186.0 COG5319@1|root,COG5319@2|Bacteria,1RKDX@1224|Proteobacteria,42SDV@68525|delta/epsilon subdivisions,2WPXR@28221|Deltaproteobacteria,43T4D@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_196853_1 555779.Dthio_PD1799 1.35e-67 232.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2M8T9@213115|Desulfovibrionales 28221|Deltaproteobacteria I ATPase BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_15311_1 1121430.JMLG01000009_gene473 9.32e-12 70.5 COG1280@1|root,COG1280@2|Bacteria,1V725@1239|Firmicutes,24KQ7@186801|Clostridia,261QM@186807|Peptococcaceae 186801|Clostridia E PFAM Lysine exporter protein (LYSE YGGA) - - - - - - - - - - - - LysE k59_152069_1 118163.Ple7327_1970 8.29e-58 213.0 COG2202@1|root,COG3829@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VMAA@52604|Pleurocapsales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_67871_1 933262.AXAM01000019_gene1105 3.3e-46 156.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WN14@28221|Deltaproteobacteria,2MJKK@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily ycbL - - - - - - - - - - - Lactamase_B k59_120059_1 215803.DB30_4823 1.24e-56 201.0 COG1475@1|root,COG1475@2|Bacteria,1RIT4@1224|Proteobacteria,4382V@68525|delta/epsilon subdivisions,2X3CV@28221|Deltaproteobacteria,2YVGI@29|Myxococcales 28221|Deltaproteobacteria K Domain of unknown function (DUF4150) - - - - - - - - - - - - DUF4150 k59_120059_2 1038922.PflQ2_2761 3.35e-18 84.3 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,1S1M0@1236|Gammaproteobacteria,1YNCV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria IQ synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_61441_1 1499967.BAYZ01000048_gene2700 3.13e-40 145.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2,MFS_3 k59_61441_2 330214.NIDE0207 2.54e-45 153.0 2E01F@1|root,32VQP@2|Bacteria 2|Bacteria S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_184799_1 396588.Tgr7_2114 6.41e-119 371.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_2566_1 754477.Q7C_2224 1.27e-46 160.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,460VI@72273|Thiotrichales 72273|Thiotrichales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_22594_1 472759.Nhal_3342 5.8e-30 125.0 2DBSQ@1|root,2ZATE@2|Bacteria,1N58C@1224|Proteobacteria,1SAPH@1236|Gammaproteobacteria,1X12X@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_106651_1 7739.XP_002586161.1 2.59e-11 70.9 KOG2177@1|root,KOG2177@2759|Eukaryota 7739.XP_002586161.1|- O zinc ion binding - - - ko:K11997 - - - - ko00000,ko04121 - - - - k59_2567_1 177437.HRM2_02300 7.51e-22 96.7 COG3366@1|root,COG3366@2|Bacteria,1NEIQ@1224|Proteobacteria,42P9X@68525|delta/epsilon subdivisions,2WM1E@28221|Deltaproteobacteria,2MHVZ@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Nucleoside recognition - - - - - - - - - - - - - k59_113170_1 1046724.KB889913_gene12 5.83e-97 291.0 COG3599@1|root,COG3599@2|Bacteria,1R4J6@1224|Proteobacteria,1T5JA@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_126650_1 768671.ThimaDRAFT_0204 9.16e-28 114.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_126650_2 454957.IA64_13370 1.93e-27 111.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales 135614|Xanthomonadales I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_191080_1 335543.Sfum_2564 6.88e-130 382.0 COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MR7F@213462|Syntrophobacterales 28221|Deltaproteobacteria C CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD,FeS k59_191081_1 671143.DAMO_0425 0.000622 43.1 COG3646@1|root,COG3646@2|Bacteria 2|Bacteria L Phage regulatory protein - - - - - - - - - - - - ORF6N k59_191081_2 880072.Desac_2678 1.97e-47 154.0 COG1553@1|root,COG1553@2|Bacteria,1NFRH@1224|Proteobacteria,42XP5@68525|delta/epsilon subdivisions,2WT3T@28221|Deltaproteobacteria 28221|Deltaproteobacteria P manually curated - - - ko:K06039 - - - - ko00000 - - - DrsE k59_164892_1 315456.RF_0336 3.41e-27 107.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,47F2K@766|Rickettsiales 766|Rickettsiales C COG1294 Cytochrome bd-type quinol oxidase, subunit 2 cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_164892_2 1232437.KL662047_gene5208 4.74e-74 236.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42P0J@68525|delta/epsilon subdivisions,2WJJQ@28221|Deltaproteobacteria,2MIYI@213118|Desulfobacterales 28221|Deltaproteobacteria C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_99848_1 404589.Anae109_3527 3.35e-32 125.0 COG1360@1|root,COG1360@2|Bacteria 2|Bacteria N Flagellar Motor Protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_73916_3 1279015.KB908457_gene2404 2.75e-37 128.0 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,1S91G@1236|Gammaproteobacteria,1Y5U1@135624|Aeromonadales 135624|Aeromonadales T Belongs to the BolA IbaG family - - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_73916_4 265072.Mfla_1158 4.95e-149 433.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VHQF@28216|Betaproteobacteria 28216|Betaproteobacteria O S6, chymotrypsin Hap - - 1.3.1.74 ko:K08070 - - - - ko00000,ko01000 - - - PDZ_2,Trypsin_2 k59_73916_9 1049564.TevJSym_bn00210 1.59e-118 347.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,1S21F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_73916_10 1049564.TevJSym_bn00220 4.86e-126 371.0 COG1638@1|root,COG1638@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K11688,ko:K21395 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_73916_12 1265505.ATUG01000001_gene4658 1.53e-30 116.0 COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,42TZJ@68525|delta/epsilon subdivisions,2WQB8@28221|Deltaproteobacteria,2MKJH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - - - - - - - - - - DctQ k59_158557_3 1033802.SSPSH_003034 1.4e-66 207.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0178 family yaiI - - ko:K09768 - - - - ko00000 - - - DUF188 k59_106660_1 1049564.TevJSym_bi00080 6.49e-195 576.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - DUF3365,EAL,GGDEF,PAS_3,PAS_9,Response_reg k59_22609_2 420662.Mpe_A0372 2.56e-38 135.0 2EVE0@1|root,33NUD@2|Bacteria,1NMKR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - zf-trcl k59_28850_1 880072.Desac_1394 1.83e-75 238.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MQA7@213462|Syntrophobacterales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_28850_2 335543.Sfum_0367 8.52e-64 205.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MQ9B@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_67881_1 380358.XALC_1285 1.83e-24 110.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1X3K8@135614|Xanthomonadales 135614|Xanthomonadales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 pilY - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_106661_1 335543.Sfum_3489 4.78e-128 384.0 COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,1QU25@1224|Proteobacteria,42YRH@68525|delta/epsilon subdivisions,2WUGB@28221|Deltaproteobacteria 28221|Deltaproteobacteria P NMT1/THI5 like - - - - - - - - - - - - NMT1 k59_54572_2 472759.Nhal_1604 7.25e-42 145.0 COG3577@1|root,COG3577@2|Bacteria,1MY8C@1224|Proteobacteria,1SBXM@1236|Gammaproteobacteria,1X0VU@135613|Chromatiales 135613|Chromatiales S gag-polyprotein putative aspartyl protease - - - - - - - - - - - - gag-asp_proteas k59_54572_3 1049564.TevJSym_bg00200 3.84e-237 660.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1J4G6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280 Aldedh k59_54572_4 1123399.AQVE01000004_gene2568 3.51e-57 186.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,460SF@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_54572_5 913325.N799_13980 2.24e-12 64.3 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1X6H0@135614|Xanthomonadales 135614|Xanthomonadales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_171678_4 1168065.DOK_11721 5.7e-26 102.0 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein pilL - - ko:K02487,ko:K18353 ko01502,ko02020,map01502,map02020 M00507,M00651 - - ko00000,ko00001,ko00002,ko01504,ko02022,ko02035 - - - TcpQ k59_171678_6 83406.HDN1F_18240 3.2e-120 374.0 COG3481@1|root,COG3481@2|Bacteria,1MUZY@1224|Proteobacteria,1RQUZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S relaxase traI - - - - - - - - - - - TraI_2,TraI_2_C k59_171678_7 1395571.TMS3_0120335 9.83e-43 166.0 COG1475@1|root,COG1475@2|Bacteria,1P9JB@1224|Proteobacteria,1RS4J@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - Arg_repressor,ParBc k59_158562_1 933262.AXAM01000005_gene2454 5.65e-67 213.0 COG0189@1|root,COG0189@2|Bacteria,1MWQA@1224|Proteobacteria,43B1R@68525|delta/epsilon subdivisions,2X6FW@28221|Deltaproteobacteria,2MJ6I@213118|Desulfobacterales 28221|Deltaproteobacteria HJ RimK-like ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_178185_1 1049564.TevJSym_aq00130 2.43e-75 231.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1J5X6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0241 Histidinol phosphatase and related phosphatases gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iJN746.PP_0059 Hydrolase_like k59_178185_2 472759.Nhal_0221 1.78e-75 238.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_178185_5 1123368.AUIS01000021_gene978 7.32e-33 129.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,2NCIP@225057|Acidithiobacillales 225057|Acidithiobacillales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N k59_61469_1 555779.Dthio_PD3122 5.3e-65 199.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2WNIG@28221|Deltaproteobacteria,2MBHM@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_35587_1 1121335.Clst_2624 3.77e-07 55.8 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3WGZ6@541000|Ruminococcaceae 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_164912_2 1049564.TevJSym_ak00680 9.7e-16 75.9 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1J5GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1530 Ribonucleases G and E rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_87245_2 1078085.HMPREF1210_00388 9.63e-49 168.0 COG0596@1|root,COG0596@2|Bacteria,1V18A@1239|Firmicutes,4HEMC@91061|Bacilli,26I5F@186818|Planococcaceae 91061|Bacilli S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_22624_1 1088721.NSU_0754 7.4e-06 53.1 COG5362@1|root,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2U236@28211|Alphaproteobacteria,2K93W@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM Phage - - - - - - - - - - - - - k59_203886_1 3055.EDP07994 0.00061 44.7 COG0318@1|root,COG3321@1|root,KOG1176@2759|Eukaryota,KOG1202@2759|Eukaryota,37NZS@33090|Viridiplantae,34PB6@3041|Chlorophyta 3041|Chlorophyta I AMP-binding enzyme C-terminal domain - - - - - - - - - - - - ADH_zinc_N_2,AMP-binding,AMP-binding_C,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_101732_1 768671.ThimaDRAFT_0226 1.29e-122 364.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales 135613|Chromatiales P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_89123_1 368407.Memar_2003 3.26e-60 207.0 COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia 224756|Methanomicrobia N PFAM type II secretion system protein E - - - ko:K07332 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_198813_1 335543.Sfum_0649 8.93e-80 264.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2MREI@213462|Syntrophobacterales 28221|Deltaproteobacteria H Pyruvate phosphate dikinase, PEP - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_4290_1 1198232.CYCME_0426 3.79e-63 201.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,46069@72273|Thiotrichales 72273|Thiotrichales E Belongs to the TrpC family trpC - 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS,PRAI k59_4290_2 1049564.TevJSym_ag00400 4.1e-42 147.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_63556_1 326298.Suden_1731 2.57e-64 209.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2YN9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM ABC transporter - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_114990_1 1123228.AUIH01000121_gene3492 2.33e-31 112.0 COG3436@1|root,COG3436@2|Bacteria,1RGZ6@1224|Proteobacteria,1S3VM@1236|Gammaproteobacteria,1XSA0@135619|Oceanospirillales 135619|Oceanospirillales L IS66 Orf2 like protein - - - - - - - - - - - - TnpB_IS66 k59_44954_1 864702.OsccyDRAFT_5075 5.5e-84 249.0 COG1943@1|root,COG1943@2|Bacteria,1G9TK@1117|Cyanobacteria,1HE74@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_205639_1 880072.Desac_2454 2.68e-24 97.4 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MQQN@213462|Syntrophobacterales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_205639_2 335543.Sfum_2584 2.12e-95 292.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MRD2@213462|Syntrophobacterales 28221|Deltaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_75793_1 316067.Geob_1388 1.48e-79 260.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,UvrD_C_2 k59_50339_1 1121405.dsmv_1597 1.14e-43 152.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,2MHT5@213118|Desulfobacterales 28221|Deltaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_50339_2 933262.AXAM01000002_gene547 3.05e-42 150.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_114996_1 335543.Sfum_1265 1.51e-31 125.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MQFN@213462|Syntrophobacterales 28221|Deltaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_140816_1 1049564.TevJSym_bd00260 4.93e-68 218.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 ko:K00113,ko:K11473 ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130 - R00475,R00848 RC00029,RC00042 ko00000,ko00001,ko01000 - - - CCG,Fer4_8 k59_45142_1 1168067.JAGP01000001_gene2122 7.46e-68 221.0 COG1960@1|root,COG1960@2|Bacteria,1NDQ8@1224|Proteobacteria,1S0J8@1236|Gammaproteobacteria,461EM@72273|Thiotrichales 72273|Thiotrichales I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_N k59_45142_2 545276.KB898728_gene171 3.23e-79 240.0 COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,1S50T@1236|Gammaproteobacteria,1X0TJ@135613|Chromatiales 135613|Chromatiales O OsmC-like protein - - - - - - - - - - - - OsmC k59_45142_3 1158760.AQXP01000050_gene504 4.29e-11 64.3 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_63732_2 1168065.DOK_15833 1.25e-74 233.0 COG0604@1|root,COG0604@2|Bacteria,1MU4N@1224|Proteobacteria,1RNSV@1236|Gammaproteobacteria,1J4IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_166903_1 1232410.KI421413_gene852 5.78e-52 167.0 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity pcaC - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_115160_2 439235.Dalk_2528 1.48e-33 122.0 2AKAT@1|root,31B1G@2|Bacteria,1N656@1224|Proteobacteria,42T13@68525|delta/epsilon subdivisions,2WPIE@28221|Deltaproteobacteria,2MKB7@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_160849_1 991905.SL003B_3002 2.94e-89 280.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,4BRAH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_160849_2 1163617.SCD_n01426 5.09e-75 240.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VN77@28216|Betaproteobacteria 28216|Betaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_160849_3 1122951.ATUE01000006_gene1391 1.13e-12 67.0 COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,1S7E9@1236|Gammaproteobacteria,3NJ2F@468|Moraxellaceae 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K18301 - M00642 - - ko00000,ko00002,ko01504,ko03000 - - - TetR_C_7,TetR_N k59_134883_1 1101189.AQUO01000002_gene146 5.58e-17 82.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2U7ZW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_134883_2 909663.KI867150_gene1507 1.06e-08 57.4 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,2MRP7@213462|Syntrophobacterales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family yjiL - - - - - - - - - - - BcrAD_BadFG k59_17478_1 1480694.DC28_10380 3.26e-28 111.0 COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes 203691|Spirochaetes S CBS domain - - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_141034_1 439235.Dalk_2420 1.45e-96 297.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria,2MIV1@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_56276_4 867903.ThesuDRAFT_00556 9.55e-274 775.0 COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WCDH@538999|Clostridiales incertae sedis 186801|Clostridia J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_56276_5 582744.Msip34_1173 1.86e-61 202.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,2KKF7@206350|Nitrosomonadales 206350|Nitrosomonadales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_134886_1 177437.HRM2_23760 6.55e-42 149.0 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MKDX@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_166911_1 909663.KI867150_gene2720 1.54e-110 333.0 COG0535@1|root,COG0535@2|Bacteria,1Q6NI@1224|Proteobacteria,433FI@68525|delta/epsilon subdivisions,2WXJT@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Radical SAM superfamily - - - - - - - - - - - - Radical_SAM k59_166911_2 1121918.ARWE01000001_gene974 3.91e-11 63.5 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,43BDC@68525|delta/epsilon subdivisions,2WK43@28221|Deltaproteobacteria 28221|Deltaproteobacteria ET Bacterial periplasmic substrate-binding proteins aapJ - - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_147778_1 335543.Sfum_3548 2.3e-107 326.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria,2MRUP@213462|Syntrophobacterales 28221|Deltaproteobacteria I 2-oxoacid dehydrogenases acyltransferase (catalytic domain) sucB - 2.3.1.12,2.3.1.61 ko:K00627,ko:K00658 ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00307 R00209,R02569,R02570,R02571,R08549 RC00004,RC02727,RC02742,RC02833,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2766 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_129088_1 1120999.JONM01000025_gene3021 1.71e-31 122.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM Forkhead-associated protein - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_205839_1 379066.GAU_2742 4.9e-21 91.7 COG0433@1|root,COG0433@2|Bacteria,1ZUJE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_141036_1 225937.HP15_3305 4.4e-28 107.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,465C4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG4149 ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_141036_2 1288826.MSNKSG1_12597 3.01e-33 122.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,4675T@72275|Alteromonadaceae 1236|Gammaproteobacteria P molybdenum ABC transporter, periplasmic modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_122673_1 237368.SCABRO_01129 1.53e-63 202.0 COG0119@1|root,COG0119@2|Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_89272_1 1049564.TevJSym_as00670 1.29e-144 432.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria,1J9WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - AMIN k59_89272_2 1255043.TVNIR_1353 2.87e-142 411.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF1329,DUF4367,LolA_like,MucB_RseB,Sigma70_r2,Sigma70_r4_2 k59_180223_1 335543.Sfum_4076 2.26e-06 48.1 COG1014@1|root,COG1014@2|Bacteria,1RBZA@1224|Proteobacteria,42QT3@68525|delta/epsilon subdivisions,2X6H9@28221|Deltaproteobacteria,2MS04@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM pyruvate ferredoxin flavodoxin oxidoreductase - - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR k59_180223_2 243231.GSU2053 1.87e-23 103.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,43UAV@69541|Desulfuromonadales 28221|Deltaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA-2 - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_166913_1 358220.C380_15430 3.65e-15 81.3 COG2199@1|root,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,2WEF3@28216|Betaproteobacteria,4ADFW@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_45154_2 857087.Metme_2353 9.48e-58 179.0 COG3668@1|root,COG3668@2|Bacteria,1PZK0@1224|Proteobacteria,1THTB@1236|Gammaproteobacteria,1XFN3@135618|Methylococcales 135618|Methylococcales S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_45154_3 261292.Nit79A3_3497 2.35e-09 55.8 2DRAI@1|root,33AYP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_4478_1 675814.VIC_002029 7.58e-09 63.5 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1XTTM@135623|Vibrionales 135623|Vibrionales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_141039_1 1129794.C427_0858 1.47e-31 112.0 2C7FC@1|root,32S1T@2|Bacteria,1N1DJ@1224|Proteobacteria,1S96F@1236|Gammaproteobacteria,468FD@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_205841_1 246194.CHY_0409 3.77e-15 77.8 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,42EMB@68295|Thermoanaerobacterales 186801|Clostridia S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_173101_1 335543.Sfum_2687 9.36e-103 314.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales 28221|Deltaproteobacteria F PFAM Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_45160_1 765913.ThidrDRAFT_0529 6.99e-176 497.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1WWJ4@135613|Chromatiales 135613|Chromatiales S Radical SAM superfamily pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_153951_1 1121405.dsmv_1991 3.35e-160 458.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit nuoF-2 - 1.6.5.3 ko:K00334,ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_82994_1 765912.Thimo_1087 3.87e-110 342.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_166921_1 177437.HRM2_46670 1.96e-35 130.0 COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2MI2R@213118|Desulfobacterales 28221|Deltaproteobacteria L A G-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_187202_2 1089439.KB902262_gene64 1.34e-09 57.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,4615I@72273|Thiotrichales 72273|Thiotrichales T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_134896_1 1121405.dsmv_2307 1.99e-32 123.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_134896_2 177437.HRM2_03780 3.35e-31 113.0 COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,42TXG@68525|delta/epsilon subdivisions,2WQI4@28221|Deltaproteobacteria,2MKN6@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_115178_1 1173021.ALWA01000006_gene3120 1.64e-141 440.0 COG1020@1|root,COG1020@2|Bacteria,1G3X6@1117|Cyanobacteria 1117|Cyanobacteria Q Thioesterase domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,PP-binding,Thioesterase k59_50530_1 335543.Sfum_4075 2.12e-103 319.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MR22@213462|Syntrophobacterales 28221|Deltaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_30885_2 1216007.AOPM01000047_gene2355 1.16e-84 272.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,2Q04U@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria I AMP-binding enzyme - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_30885_3 314345.SPV1_01772 2.94e-89 272.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria 1224|Proteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_205849_1 1116472.MGMO_104c00070 3.32e-35 130.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria 1224|Proteobacteria M PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_89282_1 305700.B447_03873 3.4e-76 249.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,2KV66@206389|Rhodocyclales 206389|Rhodocyclales U phosphate - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_70426_1 1041139.KB902746_gene3128 3.58e-09 58.2 COG0558@1|root,COG0558@2|Bacteria,1RE0I@1224|Proteobacteria,2U8YN@28211|Alphaproteobacteria,4B9WK@82115|Rhizobiaceae 28211|Alphaproteobacteria I CDP-alcohol phosphatidyltransferase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_70426_2 1496688.ER33_00555 3.98e-23 98.6 COG4589@1|root,COG4589@2|Bacteria,1GCQF@1117|Cyanobacteria 1117|Cyanobacteria S Belongs to the CDS family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_147798_1 96561.Dole_2817 9.74e-84 257.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MIJR@213118|Desulfobacterales 28221|Deltaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N k59_160868_3 268407.PWYN_12330 4.96e-22 95.5 COG5263@1|root,COG5263@2|Bacteria 2|Bacteria S dextransucrase activity - - - - - - - - - - - - CW_binding_1,Lyase_8,Lyase_8_C,Lyase_8_N,Pentapeptide_2,Peptidase_C69,SLH,WG_beta_rep k59_50537_1 1049564.TevJSym_aj00230 4.18e-122 354.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1J54C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_153960_1 926562.Oweho_2796 3.52e-14 78.6 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Big_5,LTD k59_122684_2 686340.Metal_2927 1.47e-46 171.0 2DBSQ@1|root,2ZATE@2|Bacteria,1N58C@1224|Proteobacteria,1SAPH@1236|Gammaproteobacteria,1XFMM@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_4597_1 443152.MDG893_14413 3.25e-166 486.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_46332_1 202956.BBNL01000001_gene1820 1.66e-06 49.3 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,3NJN7@468|Moraxellaceae 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_46332_2 880072.Desac_0010 5.12e-146 426.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2MQ49@213462|Syntrophobacterales 28221|Deltaproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_176024_1 1049564.TevJSym_ad01580 3.17e-218 635.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_182656_2 1049564.TevJSym_ak00920 8.8e-95 293.0 COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,1RZ26@1236|Gammaproteobacteria,1JAGM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_150214_1 1026882.MAMP_00270 8.48e-107 315.0 COG3658@1|root,COG3658@2|Bacteria,1PCRS@1224|Proteobacteria,1S5C0@1236|Gammaproteobacteria,463S4@72273|Thiotrichales 72273|Thiotrichales C Cytochrome b/b6/petB - - - - - - - - - - - - Ni_hydr_CYTB k59_150214_2 382464.ABSI01000012_gene2031 3.47e-52 179.0 COG3393@1|root,COG3393@2|Bacteria 2|Bacteria S Acetyltransferase (GNAT) family - - - ko:K06976 - - - - ko00000 - - - Acetyltransf_1,FR47 k59_150214_3 582899.Hden_3137 1.04e-32 118.0 COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2U87P@28211|Alphaproteobacteria 28211|Alphaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K04750 - - - - ko00000 - - - Glyoxalase k59_150214_4 1487953.JMKF01000042_gene2633 5.13e-05 51.2 COG3049@1|root,COG4188@1|root,COG3049@2|Bacteria,COG4188@2|Bacteria,1G5D4@1117|Cyanobacteria,1HASR@1150|Oscillatoriales 1117|Cyanobacteria M Alpha/beta hydrolase of unknown function (DUF1400) - - - - - - - - - - - - AAT,DUF1400 k59_79053_1 1049564.TevJSym_av00160 1.35e-154 449.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0008 Glutamyl- and glutaminyl-tRNA synthetases glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_111273_1 243233.MCA2593 9.27e-49 168.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,1RP8C@1236|Gammaproteobacteria,1XE2W@135618|Methylococcales 135618|Methylococcales H Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_111273_2 78245.Xaut_4098 3.08e-39 140.0 COG1891@1|root,COG1891@2|Bacteria,1QVM1@1224|Proteobacteria,2UEAB@28211|Alphaproteobacteria,3EZEP@335928|Xanthobacteraceae 28211|Alphaproteobacteria S 4-HFC-P synthase - - - - - - - - - - - - 4HFCP_synth k59_27025_2 96561.Dole_1617 6.01e-84 267.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2MIK2@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA-2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_91755_1 1049564.TevJSym_al00370 1.51e-28 110.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1J54Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_91755_2 765913.ThidrDRAFT_0967 5.08e-80 246.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_91755_3 1049564.TevJSym_al00350 4.78e-151 434.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1JA17@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_91755_4 1049564.TevJSym_al00340 2.79e-181 511.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1JA5R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O AIR synthase related protein, N-terminal domain hypE GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564 - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_163114_1 1267533.KB906734_gene4083 1.85e-08 55.1 COG5485@1|root,COG5485@2|Bacteria,3Y7UD@57723|Acidobacteria,2JN18@204432|Acidobacteriia 204432|Acidobacteriia S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_130780_1 1278309.KB907099_gene2930 1.47e-47 167.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,1T3FX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrome_C7 k59_130780_2 1049564.TevJSym_ar00350 1.11e-27 130.0 COG0484@1|root,COG0484@2|Bacteria,1Q629@1224|Proteobacteria,1RQ6X@1236|Gammaproteobacteria 1236|Gammaproteobacteria C heat shock protein binding - - - - - - - - - - - - - k59_124234_1 1265505.ATUG01000002_gene1099 2.15e-82 253.0 COG1962@1|root,COG1962@2|Bacteria,1R7QQ@1224|Proteobacteria,42YWK@68525|delta/epsilon subdivisions,2WUK4@28221|Deltaproteobacteria,2MP73@213118|Desulfobacterales 28221|Deltaproteobacteria H Tetrahydromethanopterin S-methyltransferase MtrH subunit - - - - - - - - - - - - MtrH k59_7593_1 1410618.JNKI01000003_gene2497 2.24e-46 154.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,4H3Z2@909932|Negativicutes 909932|Negativicutes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_7593_2 335543.Sfum_1571 9.15e-51 164.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2WQ8U@28221|Deltaproteobacteria,2MQK7@213462|Syntrophobacterales 28221|Deltaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_117794_1 1123401.JHYQ01000014_gene855 1.4e-68 214.0 COG4305@1|root,COG4305@2|Bacteria,1MYW4@1224|Proteobacteria,1T01P@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - ko:K20628 - - - - ko00000 - - - Cellulase,DPBB_1 k59_59417_2 1049564.TevJSym_aa01920 1.31e-210 589.0 COG0845@1|root,COG0845@2|Bacteria,1MWZ9@1224|Proteobacteria,1RM91@1236|Gammaproteobacteria,1JBVB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 k59_59417_3 1049564.TevJSym_aa01930 8.74e-77 255.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_883_2 690850.Desaf_3727 1.91e-126 372.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_202109_1 2340.JV46_05410 5.92e-72 234.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_150219_1 765913.ThidrDRAFT_0704 1.35e-113 347.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WX5R@135613|Chromatiales 135613|Chromatiales I aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_150219_2 2340.JV46_29200 1.86e-47 159.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1J4GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_98141_1 1049564.TevJSym_bd00260 2.59e-174 496.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 ko:K00113,ko:K11473 ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130 - R00475,R00848 RC00029,RC00042 ko00000,ko00001,ko01000 - - - CCG,Fer4_8 k59_98141_2 1288494.EBAPG3_16100 1.25e-61 191.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2VQ31@28216|Betaproteobacteria,37304@32003|Nitrosomonadales 28216|Betaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_156598_1 314345.SPV1_04948 2.84e-77 263.0 COG2203@1|root,COG2206@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3829@2|Bacteria,1RAQS@1224|Proteobacteria 1224|Proteobacteria T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - CBS,GAF,GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg k59_156598_2 396588.Tgr7_0126 2.95e-07 50.8 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1WY3D@135613|Chromatiales 135613|Chromatiales S Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep k59_137082_3 941449.dsx2_1827 5.59e-40 151.0 COG0438@1|root,COG0438@2|Bacteria,1R3TV@1224|Proteobacteria,42SVW@68525|delta/epsilon subdivisions,2WPMR@28221|Deltaproteobacteria,2MAH1@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_2,Glyco_trans_1_4 k59_137082_4 243159.AFE_0077 5.79e-89 278.0 COG2227@1|root,COG2227@2|Bacteria,1RHSX@1224|Proteobacteria 1224|Proteobacteria H Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_23 k59_137082_5 945713.IALB_0740 3.26e-89 289.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process rfbE - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_137082_6 1174528.JH992898_gene2012 5.96e-72 222.0 COG1898@1|root,COG1898@2|Bacteria,1G0QA@1117|Cyanobacteria,1JKJZ@1189|Stigonemataceae 1117|Cyanobacteria M dTDP-4-dehydrorhamnose 3,5-epimerase rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_137082_7 1121943.KB899994_gene1096 2.08e-162 460.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,1XHHZ@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_137082_8 1266908.AQPB01000056_gene2087 2.63e-111 331.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,1WXHP@135613|Chromatiales 135613|Chromatiales M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_137082_9 187272.Mlg_2317 6.05e-182 515.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,1WX1W@135613|Chromatiales 135613|Chromatiales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_137082_10 1049564.TevJSym_at00390 0.0 884.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 k59_137082_11 765912.Thimo_0056 1.09e-53 177.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales 135613|Chromatiales S Sterol-binding domain protein - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_137082_13 1049564.TevJSym_at00410 3.04e-156 441.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1J4ZD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_137082_14 1049564.TevJSym_at00420 5.01e-70 212.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1J6I8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein conserved in bacteria - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - DUF971 k59_176030_1 1499967.BAYZ01000163_gene6606 6.71e-78 259.0 COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K15836 - - - - ko00000,ko03000 - - - GAF_2,HTH_8,Response_reg,Sigma54_activat k59_13854_1 572477.Alvin_0495 1.7e-272 752.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_13854_2 1049564.TevJSym_bb00370 6.42e-136 398.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_13854_3 1121935.AQXX01000138_gene3183 4.61e-61 199.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1XJVK@135619|Oceanospirillales 135619|Oceanospirillales K Response regulator of the LytR AlgR family algR - - ko:K02477,ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_65821_3 1255043.TVNIR_2245 1.23e-65 207.0 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria 1236|Gammaproteobacteria H PFAM Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,TehB k59_176170_1 1064537.AGSO01000005_gene89 1.45e-07 55.1 COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4FCAI@85020|Dermabacteraceae 201174|Actinobacteria T ANTAR pdtaR GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 - ko:K22010 - M00839 - - ko00000,ko00002,ko02022 - - - ANTAR,Response_reg k59_91926_1 933262.AXAM01000047_gene2344 2.65e-87 267.0 COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria,2MHKX@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_20557_1 472759.Nhal_1898 3.76e-80 239.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_40105_1 1244869.H261_08558 2.91e-82 258.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2TT1X@28211|Alphaproteobacteria,2JQBE@204441|Rhodospirillales 204441|Rhodospirillales C LUD domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_46480_1 765911.Thivi_3617 3.19e-31 116.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales 135613|Chromatiales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_46480_2 1049564.TevJSym_as00200 2.86e-135 397.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1J4RZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_7703_1 1049564.TevJSym_au00560 7.48e-13 68.6 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1J50G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_7703_2 1565129.JSFF01000051_gene738 1.29e-106 311.0 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,2QB3U@267890|Shewanellaceae 1236|Gammaproteobacteria O Glutathione S-transferase, C-terminal domain gst5 - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_156727_3 572477.Alvin_2182 1.02e-75 249.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales 135613|Chromatiales O TIGRFAM Cytochrome c-type biogenesis protein CcmI - - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_189233_1 1049564.TevJSym_ak00730 3.49e-28 112.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_189233_2 765912.Thimo_2768 1.93e-18 85.5 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales 135613|Chromatiales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_169834_2 395495.Lcho_1651 3.64e-102 307.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,1KM0J@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_111436_1 472759.Nhal_2258 7.3e-86 267.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WX2Q@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23,OEP k59_130965_1 1049564.TevJSym_bn00130 1.5e-189 531.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1J4H1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_130965_2 765911.Thivi_3315 8.36e-06 47.4 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_79193_1 933262.AXAM01000004_gene2391 1.59e-69 217.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MJHB@213118|Desulfobacterales 28221|Deltaproteobacteria T helix_turn_helix, Lux Regulon - - - ko:K02479 - - - - ko00000,ko02022 - - - GerE,Response_reg k59_72422_1 1123389.ATXJ01000002_gene1408 5.65e-24 97.4 COG1403@1|root,COG1403@2|Bacteria,1WICD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_182807_1 103733.JNYO01000020_gene2004 1.66e-116 352.0 COG0465@1|root,COG0465@2|Bacteria,2I2U8@201174|Actinobacteria,4DYMK@85010|Pseudonocardiales 201174|Actinobacteria O ATPase family associated with various cellular activities (AAA) ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41,TPR_19,TPR_20 k59_156729_1 335543.Sfum_3689 5.33e-52 171.0 COG1309@1|root,COG1309@2|Bacteria,1PFBP@1224|Proteobacteria,43A4U@68525|delta/epsilon subdivisions,2X2CD@28221|Deltaproteobacteria,2MSAM@213462|Syntrophobacterales 28221|Deltaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_33581_1 1095769.CAHF01000011_gene2539 0.000284 48.9 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,47316@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454,ko:K12276 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_59564_1 1220534.B655_1770 4.29e-69 223.0 COG2303@1|root,arCOG02232@2157|Archaea,2Y89C@28890|Euryarchaeota,23NTI@183925|Methanobacteria 183925|Methanobacteria E PFAM Glucose-methanol-choline oxidoreductase, N-terminal - - - - - - - - - - - - GMC_oxred_N k59_67483_2 1232683.ADIMK_3579 1.16e-32 127.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465TA@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF domain dosP - 3.1.4.52 ko:K13243 - - R08991 RC00296 ko00000,ko01000 - - - EAL,GAF_2,GGDEF,MASE3,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_54318_1 411154.GFO_2935 3.34e-28 117.0 COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,1HWUI@117743|Flavobacteriia 976|Bacteroidetes P heavy metal translocating P-type ATPase silP - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_22318_1 240016.ABIZ01000001_gene3276 2.85e-30 117.0 COG1748@1|root,COG1748@2|Bacteria,46U4S@74201|Verrucomicrobia,2ITQI@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Saccharopine dehydrogenase C-terminal domain - - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_22318_2 1217712.F971_03707 1.01e-53 172.0 COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,1S60C@1236|Gammaproteobacteria,3NNJK@468|Moraxellaceae 1236|Gammaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_22318_4 1049564.TevJSym_ab01840 9.05e-72 218.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1J6Y3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2927 DNA polymerase III, chi subunit holC GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_22318_5 323848.Nmul_A0746 8.44e-27 108.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,372AV@32003|Nitrosomonadales 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_184514_1 1123228.AUIH01000121_gene3493 1.16e-67 224.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1XIK6@135619|Oceanospirillales 135619|Oceanospirillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_184514_2 270374.MELB17_24262 2.33e-21 87.4 COG2963@1|root,COG2963@2|Bacteria,1NGD6@1224|Proteobacteria,1SFD4@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_151878_1 1123237.Salmuc_02804 5.14e-22 101.0 2D2IW@1|root,32TCX@2|Bacteria,1N4MH@1224|Proteobacteria,2U5DM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1353) - - - - - - - - - - - - DUF1353 k59_177869_1 1198114.AciX9_1732 2.91e-27 114.0 COG3046@1|root,COG3046@2|Bacteria,3Y47V@57723|Acidobacteria,2JJ03@204432|Acidobacteriia 204432|Acidobacteriia S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_164596_1 485913.Krac_5974 4.14e-64 202.0 2CI52@1|root,2ZC5H@2|Bacteria,2G6K9@200795|Chloroflexi 200795|Chloroflexi - - - - - - - - - - - - - - - k59_164596_3 748280.NH8B_1775 8.23e-32 137.0 COG3115@1|root,COG3170@1|root,COG3115@2|Bacteria,COG3170@2|Bacteria,1QYE5@1224|Proteobacteria,2VJJ0@28216|Betaproteobacteria 28216|Betaproteobacteria DNU Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_164596_5 99598.Cal7507_3726 2.64e-136 408.0 COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria,1HMQN@1161|Nostocales 1117|Cyanobacteria O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_112905_1 1121434.AULY01000011_gene1785 1.12e-05 52.8 COG3728@1|root,COG3728@2|Bacteria,1RG2M@1224|Proteobacteria,433MN@68525|delta/epsilon subdivisions,2WXZI@28221|Deltaproteobacteria,2MBVH@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM Terminase small subunit - - - ko:K07474 - - - - ko00000 - - - Terminase_2 k59_112905_5 760192.Halhy_2791 5.8e-15 75.1 COG3550@1|root,COG3550@2|Bacteria,4P8S8@976|Bacteroidetes,1J020@117747|Sphingobacteriia 976|Bacteroidetes S peptidyl-serine autophosphorylation - - - - - - - - - - - - - k59_93825_1 706587.Desti_2519 1.09e-128 381.0 COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MQT5@213462|Syntrophobacterales 28221|Deltaproteobacteria C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_132649_1 13333.ERN05726 2.66e-26 108.0 COG0846@1|root,KOG1905@2759|Eukaryota,37JIC@33090|Viridiplantae,3GCS3@35493|Streptophyta 35493|Streptophyta BK NAD-dependent protein deacetylase - - 2.4.2.31 ko:K11416 ko04714,ko05230,map04714,map05230 - - - ko00000,ko00001,ko01000,ko03036 - - - SIR2 k59_119703_1 670292.JH26_24975 5.64e-39 141.0 COG0500@1|root,COG2226@2|Bacteria,1R79J@1224|Proteobacteria,2U421@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_42035_1 768671.ThimaDRAFT_1748 6.49e-110 323.0 COG0650@1|root,COG0650@2|Bacteria,1QE37@1224|Proteobacteria,1RZJC@1236|Gammaproteobacteria,1WWZT@135613|Chromatiales 135613|Chromatiales C pfam nadh - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_42035_2 1049564.TevJSym_ad00500 7.88e-59 198.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1J4RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP Proton-conducting membrane transporter phaD - 1.6.5.3 ko:K00342,ko:K05561,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_2281_3 1348583.ATLH01000017_gene2670 1.35e-56 213.0 COG3291@1|root,COG3291@2|Bacteria,4PKJH@976|Bacteroidetes,1IJAY@117743|Flavobacteriia,1FAMT@104264|Cellulophaga 976|Bacteroidetes E PKD domain - - - - - - - - - - - - Big_5,Malectin,PKD k59_158209_1 1173020.Cha6605_2100 5.49e-60 199.0 COG3344@1|root,COG3344@2|Bacteria,1G791@1117|Cyanobacteria 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_73683_1 1049564.TevJSym_ac01920 3.79e-23 99.8 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1J4C1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_73683_2 314285.KT71_17496 3.98e-12 65.5 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1J9SE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat-like domain yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_145475_1 1101191.KI912577_gene3293 4.03e-14 72.0 COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2U05J@28211|Alphaproteobacteria,1JT3M@119045|Methylobacteriaceae 28211|Alphaproteobacteria KT HD domain - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - HD_4 k59_9241_1 317025.Tcr_0436 1.89e-106 313.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,1S5NE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_9241_2 317025.Tcr_0435 5.31e-190 541.0 COG4591@1|root,COG4591@2|Bacteria,1RD9H@1224|Proteobacteria,1SZ4B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_9241_3 317025.Tcr_0434 3.78e-203 574.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain VPA0559 - - - - - - - - - - - FtsX,MacB_PCD k59_15178_1 1049564.TevJSym_bd00040 4.67e-123 362.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1J515@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Flavocytochrome c sulphide dehydrogenase, flavin-binding fccB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_15178_3 471874.PROSTU_04774 5.17e-81 248.0 COG0819@1|root,COG0819@2|Bacteria,1NY0S@1224|Proteobacteria,1SPY3@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_15178_4 537972.ABQU01000014_gene750 1.32e-83 263.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2YMRZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_15178_5 1177154.Y5S_03551 3.63e-33 128.0 COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,1RZ0R@1236|Gammaproteobacteria,1XJPU@135619|Oceanospirillales 135619|Oceanospirillales S PhzC PhzF - - - - - - - - - - - - PhzC-PhzF k59_15178_7 1536773.R70331_05225 6.06e-132 422.0 COG0574@1|root,COG0574@2|Bacteria,1UJVW@1239|Firmicutes 1239|Firmicutes G Pyruvate phosphate dikinase, PEP pyruvate binding domain protein - - 2.7.3.13,2.7.9.2 ko:K01007,ko:K22424 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_80661_1 1219080.VEZ01S_01_00990 1.59e-37 142.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XUFQ@135623|Vibrionales 135623|Vibrionales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_151887_1 439235.Dalk_4111 3.39e-91 291.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MHSK@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_28575_1 187272.Mlg_0386 2e-22 95.9 2C87N@1|root,2ZCQ2@2|Bacteria,1RBNP@1224|Proteobacteria,1S2KA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3800) - - - - - - - - - - - - DUF3800 k59_196747_1 1049564.TevJSym_ba00030 4.86e-62 212.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_196747_4 640081.Dsui_0532 1.95e-96 286.0 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,2VM7I@28216|Betaproteobacteria,2KVDE@206389|Rhodocyclales 206389|Rhodocyclales H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids cobO - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Co_AT_N,CobA_CobO_BtuR k59_22325_1 1260251.SPISAL_06805 6.38e-216 602.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_158218_1 1537994.JQFW01000056_gene840 1.28e-133 388.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,464JN@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_112915_2 1190606.AJYG01000196_gene2099 5.06e-55 180.0 COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,1RP91@1236|Gammaproteobacteria,1XUQQ@135623|Vibrionales 135623|Vibrionales O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - ko:K03188 - - - - ko00000 - - - UreF k59_106277_1 517418.Ctha_1390 1.51e-96 300.0 COG1274@1|root,COG1274@2|Bacteria,1FDFQ@1090|Chlorobi 1090|Chlorobi H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_67509_1 1049564.TevJSym_bd00140 1.39e-95 308.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_145594_1 880072.Desac_0872 4.33e-56 184.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42MSC@68525|delta/epsilon subdivisions,2WJAH@28221|Deltaproteobacteria 28221|Deltaproteobacteria E ABC transporter related - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_2434_1 439235.Dalk_5170 2.95e-05 49.3 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MKDX@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_99718_1 656024.FsymDg_1553 2e-12 71.2 COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4ESGS@85013|Frankiales 201174|Actinobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_106477_1 1049564.TevJSym_as00280 0.000509 42.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_106477_2 765910.MARPU_15020 6.36e-171 484.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales 135613|Chromatiales T PFAM PhoH family protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_106477_3 1236541.BALL01000044_gene4031 1.49e-07 51.6 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,2QBMX@267890|Shewanellaceae 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_54471_2 1157708.KB907455_gene3468 2.95e-36 130.0 2CMCS@1|root,32SEB@2|Bacteria,1N3SA@1224|Proteobacteria,2VTVV@28216|Betaproteobacteria,4AFRC@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_54471_3 1396141.BATP01000024_gene839 6.9e-62 213.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,PG_binding_1 k59_54471_4 543728.Vapar_0538 2.49e-101 311.0 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2VS1K@28216|Betaproteobacteria,4AERZ@80864|Comamonadaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2169) - - - - - - - - - - - - DUF2169 k59_54471_5 330214.NIDE1991 5.26e-105 318.0 COG0304@1|root,COG0304@2|Bacteria 2|Bacteria I 3-oxoacyl-[acyl-carrier-protein] synthase activity - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ketoacyl-synt k59_54471_6 330214.NIDE1992 7.6e-54 179.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - - - - - - - - - - DUF4150,Tox-GHH2 k59_22498_2 401526.TcarDRAFT_0950 1.52e-16 86.7 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4H2F4@909932|Negativicutes 909932|Negativicutes T Histidine kinase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,sCache_like k59_42248_4 1129794.C427_5226 2.33e-13 66.2 2DBQY@1|root,2ZAHD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_42248_5 1190606.AJYG01000057_gene3878 8.4e-93 284.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1XVNR@135623|Vibrionales 135623|Vibrionales L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_164781_1 335543.Sfum_1583 8.89e-51 164.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MQIR@213462|Syntrophobacterales 28221|Deltaproteobacteria J PFAM ribosomal protein L17 rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_164781_2 335543.Sfum_1582 1.36e-115 340.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MR47@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_48217_1 1144343.PMI41_00534 4.54e-74 229.0 COG1309@1|root,COG1309@2|Bacteria,1R4IA@1224|Proteobacteria,2U4FJ@28211|Alphaproteobacteria,43KVB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_184700_1 203122.Sde_0444 2.36e-156 447.0 28IFP@1|root,2Z8HD@2|Bacteria,1RDUQ@1224|Proteobacteria,1S56N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3644) - - - - - - - - - - - - DUF3644 k59_94067_2 1049564.TevJSym_ap00150 1.08e-162 474.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1J55U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase pcoA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_173074_1 96561.Dole_2374 1.16e-120 352.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales 28221|Deltaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_140996_2 1385515.N791_07295 7.8e-52 176.0 COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,1T1K8@1236|Gammaproteobacteria,1X3DZ@135614|Xanthomonadales 135614|Xanthomonadales I The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_115149_1 765910.MARPU_15835 3.23e-21 99.4 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_109041_2 335543.Sfum_1573 2.04e-21 85.1 COG1841@1|root,COG1841@2|Bacteria,1QTFU@1224|Proteobacteria,43F36@68525|delta/epsilon subdivisions,2X37G@28221|Deltaproteobacteria,2MSA2@213462|Syntrophobacterales 28221|Deltaproteobacteria J PFAM ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_187160_1 1232437.KL662042_gene2012 2.55e-69 224.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2MMEZ@213118|Desulfobacterales 28221|Deltaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_96712_2 396588.Tgr7_0389 2.12e-67 215.0 2D80K@1|root,32TQ4@2|Bacteria,1N4HE@1224|Proteobacteria,1SC5V@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_180196_2 1399774.JDWH01000007_gene1687 1.2e-14 75.9 COG3209@1|root,COG4104@1|root,COG3209@2|Bacteria,COG4104@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - PAAR_motif,RHS,RHS_repeat,Tox-HNH-EHHH k59_101891_1 1191523.MROS_0139 2.51e-214 603.0 COG0017@1|root,COG0017@2|Bacteria 2|Bacteria J Asparaginyl-tRNA synthetase asnS GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_153943_1 765912.Thimo_2134 2.68e-71 233.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWES@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_70380_1 879212.DespoDRAFT_03401 6.85e-59 194.0 COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,2MI7M@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM phosphoesterase RecJ domain protein - - - - - - - - - - - - DHH,DHHA1 k59_63724_1 768671.ThimaDRAFT_3909 9.94e-88 267.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_63724_3 1430440.MGMSRv2_1032 4.81e-151 440.0 COG5424@1|root,COG5424@2|Bacteria,1NM66@1224|Proteobacteria,2UR4P@28211|Alphaproteobacteria,2JV56@204441|Rhodospirillales 204441|Rhodospirillales H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - - - - - - - - - - - - k59_63724_5 870187.Thini_2956 2.54e-57 183.0 COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,1S44Q@1236|Gammaproteobacteria,463JT@72273|Thiotrichales 72273|Thiotrichales K NikR C terminal nickel binding domain - - - - - - - - - - - - NikR_C,RHH_1 k59_63724_6 768671.ThimaDRAFT_4109 3.23e-128 371.0 COG5266@1|root,COG5266@2|Bacteria,1PVKN@1224|Proteobacteria,1RWJZ@1236|Gammaproteobacteria,1WXIW@135613|Chromatiales 135613|Chromatiales P PFAM Nickel transport complex, NikM subunit, transmembrane - - - ko:K02009 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18 - - DUF4198 k59_63724_8 765913.ThidrDRAFT_1669 1.18e-55 179.0 COG0310@1|root,COG0310@2|Bacteria,1RJRC@1224|Proteobacteria,1S6H0@1236|Gammaproteobacteria,1WX9R@135613|Chromatiales 135613|Chromatiales P PFAM Cobalt uptake substrate-specific transmembrane region - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_198996_1 1121377.KB906404_gene2963 1.78e-28 119.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity ywqA - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SWIM k59_89259_2 748247.AZKH_2581 2.17e-147 423.0 COG0583@1|root,COG0583@2|Bacteria,1MV06@1224|Proteobacteria,2VHGD@28216|Betaproteobacteria,2KUSF@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_89259_3 420662.Mpe_A0870 7.11e-92 281.0 COG0657@1|root,COG0657@2|Bacteria,1MW4D@1224|Proteobacteria,2VIHB@28216|Betaproteobacteria,1KNJG@119065|unclassified Burkholderiales 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_89259_4 398578.Daci_5137 1.07e-138 409.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VHW3@28216|Betaproteobacteria,4AA9A@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family bepF - - ko:K18901 - M00698 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_50501_1 349124.Hhal_2231 9.47e-09 55.8 COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,1T1HV@1236|Gammaproteobacteria,1X2QM@135613|Chromatiales 135613|Chromatiales S KR domain - - - - - - - - - - - - adh_short k59_50501_4 1049564.TevJSym_ar00050 1.17e-33 124.0 COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1J6N7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sporulation related domain dedD - - ko:K03749 - - - - ko00000 - - - SPOR k59_50501_5 1049564.TevJSym_ar00060 6.88e-148 434.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1J4MK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the folylpolyglutamate synthase family folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_1997,iSDY_1059.SDY_2514 Mur_ligase_C,Mur_ligase_M k59_75970_2 1150469.RSPPHO_02159 1e-33 124.0 COG1846@1|root,COG1846@2|Bacteria,1MZEJ@1224|Proteobacteria,2U8EI@28211|Alphaproteobacteria 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_75970_3 857087.Metme_1124 5.38e-163 512.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_109048_1 1316927.ATKI01000034_gene4592 1.56e-139 420.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1SKJU@1236|Gammaproteobacteria,1YSB6@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_147763_1 1049564.TevJSym_as00660 1.44e-13 69.7 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_147763_2 323848.Nmul_A0367 6.69e-57 189.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VQWS@28216|Betaproteobacteria,371ZC@32003|Nitrosomonadales 28216|Betaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_147763_3 1049564.TevJSym_bt00100 4.48e-161 464.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria,1JBVR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain VPA0559 - - - - - - - - - - - FtsX,MacB_PCD k59_205829_1 1121935.AQXX01000054_gene2930 1.11e-121 350.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1XKC3@135619|Oceanospirillales 135619|Oceanospirillales D COG1192 ATPases involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_205829_2 1121935.AQXX01000054_gene2931 2.25e-38 130.0 2EFZJ@1|root,339RR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_4462_1 335543.Sfum_2202 5.08e-23 92.4 COG0517@1|root,COG0517@2|Bacteria,1QUKQ@1224|Proteobacteria,42TPD@68525|delta/epsilon subdivisions,2WQQ5@28221|Deltaproteobacteria,2MRW0@213462|Syntrophobacterales 28221|Deltaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_4462_2 1232410.KI421412_gene179 2.24e-18 84.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria,43TCG@69541|Desulfuromonadales 28221|Deltaproteobacteria M HlyD family secretion protein - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_63922_5 1279017.AQYJ01000028_gene2261 1.1e-110 327.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,4664W@72275|Alteromonadaceae 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VP1287 - - - - - - - - - - - LolA_like k59_63922_6 1279017.AQYJ01000028_gene2260 3.92e-297 842.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,465BT@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_63922_8 1050202.KB913024_gene1718 2.02e-08 61.2 COG1309@1|root,COG1309@2|Bacteria,2I8MS@201174|Actinobacteria,409G5@622450|Actinopolysporales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_4623_1 1265505.ATUG01000003_gene324 3.51e-44 155.0 COG2768@1|root,COG2768@2|Bacteria,1R08Q@1224|Proteobacteria,43CRC@68525|delta/epsilon subdivisions,2X7YY@28221|Deltaproteobacteria,2MPKX@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - - - - - - - - - - Fer4 k59_115380_1 1123228.AUIH01000131_gene2866 1.71e-199 573.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,1XS1N@135619|Oceanospirillales 135619|Oceanospirillales L IS66 C-terminal element - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_135038_3 768671.ThimaDRAFT_2269 1.27e-13 72.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales 135613|Chromatiales C TIGRFAM cytochrome c oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_199250_1 1591073.A0A0B5CU19_9CAUD 0.000909 49.3 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098026 - - - - - - - - - - - k59_199250_4 658401.C7F4B8_9CAUD 2.6e-07 57.4 4QH5W@10239|Viruses,4QYFG@35237|dsDNA viruses no RNA stage,4QQD8@28883|Caudovirales,4QN2T@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_115381_1 941449.dsx2_1623 1.74e-86 269.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Q49@68525|delta/epsilon subdivisions,2X5E9@28221|Deltaproteobacteria,2M8TQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_167198_1 56780.SYN_01181 1.01e-51 176.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MQY6@213462|Syntrophobacterales 28221|Deltaproteobacteria KT PFAM Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_12039_1 525897.Dbac_0731 6.68e-17 75.5 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,42WWI@68525|delta/epsilon subdivisions,2WSR8@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_12039_2 138119.DSY4580 7.35e-17 80.1 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,266RX@186807|Peptococcaceae 186801|Clostridia L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_173285_1 96561.Dole_0430 2.07e-16 76.3 COG3462@1|root,COG3462@2|Bacteria,1Q55M@1224|Proteobacteria,42WZ8@68525|delta/epsilon subdivisions,2WSP8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_70671_1 1049564.TevJSym_aw00260 5.16e-13 63.9 COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_70671_2 768671.ThimaDRAFT_3391 1.54e-102 303.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales 135613|Chromatiales S PKHD-type hydroxylase - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_70671_3 768671.ThimaDRAFT_3392 4.29e-30 113.0 28QMK@1|root,2ZD39@2|Bacteria,1RAWM@1224|Proteobacteria,1S2FU@1236|Gammaproteobacteria,1WY0Y@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_17686_1 1265505.ATUG01000001_gene2861 1.73e-86 268.0 COG3829@1|root,COG3829@2|Bacteria,1N1WB@1224|Proteobacteria,42P76@68525|delta/epsilon subdivisions,2WIU6@28221|Deltaproteobacteria,2MIIW@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_96942_1 1405.DJ92_3566 0.000435 47.8 COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,1ZDDG@1386|Bacillus 91061|Bacilli EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_3,Sugar_tr k59_147974_1 582899.Hden_1340 2.67e-21 98.2 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_76227_1 519989.ECTPHS_12515 1.09e-33 130.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_199270_1 243231.GSU2033 6.98e-16 72.8 COG1476@1|root,COG1476@2|Bacteria,1NB6T@1224|Proteobacteria,42VWK@68525|delta/epsilon subdivisions,2WRMY@28221|Deltaproteobacteria,43VV4@69541|Desulfuromonadales 28221|Deltaproteobacteria K PFAM helix-turn-helix domain protein - - - - - - - - - - - - HTH_3 k59_25045_1 696281.Desru_1453 9.92e-10 65.1 COG1566@1|root,COG1566@2|Bacteria,1UJ4C@1239|Firmicutes,25G1C@186801|Clostridia,267E1@186807|Peptococcaceae 186801|Clostridia V PFAM secretion protein HlyD family protein - - - ko:K01993,ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_38145_3 1122201.AUAZ01000004_gene3434 5.92e-23 97.4 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1R7KV@1224|Proteobacteria,1RZ25@1236|Gammaproteobacteria,46BUU@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA methylase VP0394 - 2.1.1.72 ko:K00571,ko:K07319 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_38145_4 1068980.ARVW01000001_gene6726 8.65e-25 103.0 COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria,4DZCK@85010|Pseudonocardiales 201174|Actinobacteria S Carbon-nitrogen hydrolase - - 3.5.5.1 ko:K01501 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_56463_2 1198232.CYCME_0777 3.47e-20 95.5 COG1525@1|root,COG1525@2|Bacteria,1RKRQ@1224|Proteobacteria,1S5D6@1236|Gammaproteobacteria,463IG@72273|Thiotrichales 72273|Thiotrichales L Staphylococcal nuclease homologues - - - - - - - - - - - - SNase k59_147976_1 765910.MARPU_09845 2.44e-52 173.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_147976_2 1049564.TevJSym_ac01190 7.11e-190 536.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_56465_1 56780.SYN_00152 3.1e-83 265.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR61@213462|Syntrophobacterales 28221|Deltaproteobacteria C NADH ubiquinone oxidoreductase, NADH-binding - - 1.12.1.3,1.6.5.3 ko:K00124,ko:K00335,ko:K18331 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_193080_1 1121949.AQXT01000002_gene1462 6.83e-43 143.0 COG3422@1|root,COG3422@2|Bacteria,1N0S6@1224|Proteobacteria,2VCP9@28211|Alphaproteobacteria,43YYM@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1508) - - - - - - - - - - - - DUF1508 k59_4636_1 1385935.N836_21445 1.83e-12 73.2 COG0001@1|root,COG3321@1|root,COG0001@2|Bacteria,COG3321@2|Bacteria,1G25N@1117|Cyanobacteria,1HA4D@1150|Oscillatoriales 1117|Cyanobacteria HQ Acyl transferase domain in polyketide synthase (PKS) enzymes. mcyE - - ko:K16129 ko01054,map01054 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt k59_96962_1 880072.Desac_0826 1.07e-122 362.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_147982_1 1499967.BAYZ01000068_gene1960 6.32e-29 114.0 COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria 2|Bacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_4638_1 338966.Ppro_1142 9.65e-25 102.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,43TES@69541|Desulfuromonadales 28221|Deltaproteobacteria D integrase domain protein SAM domain protein xerD - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_25056_2 765913.ThidrDRAFT_4480 0.000316 48.9 2CGCV@1|root,31JER@2|Bacteria,1RJJ8@1224|Proteobacteria,1SA8N@1236|Gammaproteobacteria,1X0SG@135613|Chromatiales 135613|Chromatiales S Thrombospondin C-terminal region - - - - - - - - - - - - TSP_C k59_187417_4 742767.HMPREF9456_02037 9.72e-11 62.4 2EG79@1|root,339Z6@2|Bacteria,4NZPC@976|Bacteroidetes,2FY3M@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_161048_4 314282.PCNPT3_01345 4.79e-76 246.0 COG5653@1|root,COG5653@2|Bacteria,1N7WR@1224|Proteobacteria,1S762@1236|Gammaproteobacteria,2QHWB@267894|Psychromonadaceae 1236|Gammaproteobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_154235_1 1499967.BAYZ01000017_gene6234 9.33e-88 276.0 COG0028@1|root,COG0028@2|Bacteria,2NNMW@2323|unclassified Bacteria 2|Bacteria EH thiamine pyrophosphate protein TPP binding domain protein ilvB1 GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_91870_2 1137745.H6WFS7_9CAUD 1.43e-23 97.8 4QCXM@10239|Viruses,4QZZ5@35237|dsDNA viruses no RNA stage,4QT8U@28883|Caudovirales,4QJ27@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_202180_1 667014.Thein_1260 2.17e-93 293.0 COG1916@1|root,COG1916@2|Bacteria,2GGX4@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria - - - - - - - - - - - - - - - k59_195361_1 643648.Slip_1461 1.38e-35 130.0 COG5423@1|root,COG5423@2|Bacteria,1U3SS@1239|Firmicutes,258M0@186801|Clostridia,42KXB@68298|Syntrophomonadaceae 186801|Clostridia S Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284 k59_124344_1 335543.Sfum_0736 3.1e-44 155.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2MQRE@213462|Syntrophobacterales 28221|Deltaproteobacteria E Pyridoxal-phosphate dependent enzyme tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_124344_2 1033802.SSPSH_002028 2.74e-28 114.0 COG0584@1|root,COG0584@2|Bacteria,1QHQ6@1224|Proteobacteria,1S8CK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C glycerophosphoryl diester phosphodiesterase avrBs2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_189189_1 1123400.KB904748_gene343 1.07e-41 140.0 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,463BJ@72273|Thiotrichales 72273|Thiotrichales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_117918_1 246199.CUS_4650 7.16e-71 227.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,3WIAE@541000|Ruminococcaceae 186801|Clostridia L PFAM Transposase, Mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_143799_1 62928.azo2040 1.2e-42 143.0 28MWI@1|root,316EA@2|Bacteria,1PXEU@1224|Proteobacteria,2WB6Q@28216|Betaproteobacteria,2KZIS@206389|Rhodocyclales 206389|Rhodocyclales S plasmid encoded RepA protein - - - - - - - - - - - - RepA_C k59_143799_2 402626.Rpic_4337 7.19e-30 107.0 COG3668@1|root,COG3668@2|Bacteria,1MZIN@1224|Proteobacteria,2VUR2@28216|Betaproteobacteria 28216|Betaproteobacteria S Plasmid stabilization - - - - - - - - - - - - ParE_toxin k59_65891_1 1499967.BAYZ01000048_gene2698 5.03e-131 384.0 COG2907@1|root,COG2907@2|Bacteria,2NS11@2323|unclassified Bacteria 2|Bacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_163190_2 1123228.AUIH01000065_gene3063 1.05e-11 61.2 2ENZF@1|root,33GKB@2|Bacteria,1NGMD@1224|Proteobacteria,1SHNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxin SymE, type I toxin-antitoxin system - - - ko:K19048 - - - - ko00000,ko02048 - - - SymE_toxin k59_163190_3 195250.CM001776_gene962 5.55e-33 118.0 COG3620@1|root,COG3620@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - DUF4870,HTH_3,HTH_31 k59_163190_4 1123228.AUIH01000091_gene569 6.98e-149 456.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_967_1 1121939.L861_08785 5.93e-152 450.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_967_2 1121939.L861_08790 1.59e-40 144.0 COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,1S6EP@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Pilus assembly protein CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_7683_1 1121422.AUMW01000014_gene1350 3.07e-13 73.2 COG0702@1|root,COG0702@2|Bacteria,1TWZS@1239|Firmicutes,24EGR@186801|Clostridia,266V5@186807|Peptococcaceae 186801|Clostridia M NmrA-like family - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_117919_1 338966.Ppro_3708 3.71e-63 204.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_124352_1 1049564.TevJSym_bp00060 9.04e-86 275.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_13923_2 159087.Daro_1765 4.58e-51 170.0 COG1556@1|root,COG1556@2|Bacteria,1RJ6A@1224|Proteobacteria,2VSIZ@28216|Betaproteobacteria,2KWQE@206389|Rhodocyclales 206389|Rhodocyclales S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_150341_1 765912.Thimo_2579 7.86e-38 139.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_150341_3 1049564.TevJSym_am00810 1.72e-70 216.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1J6ZE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_150341_4 1049564.TevJSym_am00800 4.49e-80 245.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_143801_3 1123368.AUIS01000006_gene546 4.11e-48 155.0 2BRYG@1|root,32KYR@2|Bacteria,1N0U5@1224|Proteobacteria,1SBY8@1236|Gammaproteobacteria,2NE3P@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_137170_1 205922.Pfl01_2212 1.9e-56 201.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YQ2C@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Condensation domain - - - ko:K15659 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_111523_2 1049564.TevJSym_aj00020 1.32e-74 229.0 2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,1S3S1@1236|Gammaproteobacteria,1JAD6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_79347_1 431943.CKL_0936 1.74e-42 147.0 COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HU5@186801|Clostridia,36DWS@31979|Clostridiaceae 186801|Clostridia S hmm pf02632 bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY k59_156853_1 351348.Maqu_2678 3.35e-16 75.1 COG4737@1|root,COG4737@2|Bacteria 2|Bacteria G Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - RelE k59_156853_2 472759.Nhal_2352 8.25e-52 165.0 COG2944@1|root,COG2944@2|Bacteria,1N05Y@1224|Proteobacteria,1SCCM@1236|Gammaproteobacteria,1WYCH@135613|Chromatiales 135613|Chromatiales K Helix-turn-helix XRE-family like proteins - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3 k59_124529_1 717231.Flexsi_0440 1.25e-56 188.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_118092_1 697282.Mettu_2858 1.76e-12 68.9 COG3335@1|root,COG3335@2|Bacteria,1R1IX@1224|Proteobacteria,1T547@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Transposase, Rhodopirellula-type - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_118092_2 1095752.HMPREF9969_2503 2.05e-60 206.0 COG3335@1|root,COG3335@2|Bacteria,4P3SJ@976|Bacteroidetes,2FXXE@200643|Bacteroidia 976|Bacteroidetes L Rhodopirellula transposase DDE domain - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_1105_1 335543.Sfum_3197 1.67e-121 368.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MQ7P@213462|Syntrophobacterales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_176274_1 935548.KI912159_gene3944 3.85e-72 233.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,43IWV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E PFAM Pyridoxal-dependent decarboxylase - - - - - - - - - - - - Pyridoxal_deC k59_182934_1 644282.Deba_2109 9.98e-55 192.0 COG4775@1|root,COG5616@1|root,COG4775@2|Bacteria,COG5616@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_111525_1 713586.KB900536_gene2656 1.23e-185 522.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales 135613|Chromatiales L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_150505_1 1201293.AKXQ01000001_gene2036 2.17e-53 197.0 COG0834@1|root,COG2202@1|root,COG4585@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - - - - - - - - - - - EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3 k59_79351_1 243231.GSU2414 4.2e-65 221.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,42N9P@68525|delta/epsilon subdivisions,2WJ0G@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_92070_1 1121405.dsmv_0327 1.9e-85 262.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria,2MIMS@213118|Desulfobacterales 28221|Deltaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_137283_1 120017.I2FQM7 2.79e-07 59.7 COG0642@1|root,KOG0519@2759|Eukaryota,38EIJ@33154|Opisthokonta,3NVY0@4751|Fungi,3UYEV@5204|Basidiomycota,3N2YH@452284|Ustilaginomycotina 4751|Fungi T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_72561_1 857087.Metme_3901 7.05e-59 205.0 COG2202@1|root,COG4251@1|root,COG5278@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_118095_1 1120998.AUFC01000017_gene114 1.85e-08 52.8 COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia 186801|Clostridia K Probable zinc-ribbon domain - - - - - - - - - - - - zf-trcl k59_33731_1 1049564.TevJSym_am00190 1.44e-79 245.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1J5GD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0282,ic_1306.c0493 F420_oxidored,P5CR_dimer k59_33731_2 243160.BMA2411 6.07e-86 262.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1JZTS@119060|Burkholderiaceae 28216|Betaproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_150507_3 287.DR97_4609 2.62e-53 173.0 2F7IQ@1|root,33ZZB@2|Bacteria,1NXMP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_92076_1 1249627.D779_1516 1.88e-80 256.0 COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,1RZXJ@1236|Gammaproteobacteria,1WXWR@135613|Chromatiales 135613|Chromatiales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_20723_1 1121405.dsmv_1000 2.46e-28 114.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,2MI7N@213118|Desulfobacterales 28221|Deltaproteobacteria J MiaB-like tRNA modifying enzyme mtaB - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_20723_2 1232437.KL662010_gene1608 1.93e-33 119.0 2EACD@1|root,334GB@2|Bacteria,1NETT@1224|Proteobacteria,42V8Z@68525|delta/epsilon subdivisions,2WRR6@28221|Deltaproteobacteria,2MKWJ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - - k59_20723_3 502025.Hoch_6589 9.15e-12 65.1 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_156855_1 1500897.JQNA01000002_gene5330 2.27e-05 51.2 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,2VMA0@28216|Betaproteobacteria,1K4WD@119060|Burkholderiaceae 28216|Betaproteobacteria V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_156855_2 485918.Cpin_6207 1.59e-14 70.1 COG1254@1|root,COG1254@2|Bacteria,4NVB4@976|Bacteroidetes,1ITWQ@117747|Sphingobacteriia 976|Bacteroidetes C Belongs to the acylphosphatase family acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_156855_3 1049564.TevJSym_af00720 4.78e-105 310.0 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,1RQ95@1236|Gammaproteobacteria,1J5WH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the SfsA family sfsA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K06206 - - - - ko00000 - - - SfsA k59_156855_4 686578.AFFX01000008_gene2710 3.44e-67 214.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_202349_2 1317124.DW2_10279 1.01e-34 135.0 COG0715@1|root,COG4191@1|root,COG0715@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2XN4X@285107|Thioclava 28211|Alphaproteobacteria PT ABC transporter, phosphonate, periplasmic substrate-binding protein dctS - 2.7.13.3 ko:K11711 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,Phosphonate-bd,dCache_1 k59_170002_2 248742.XP_005651052.1 1.64e-50 182.0 COG1026@1|root,KOG2019@2759|Eukaryota,37R6J@33090|Viridiplantae,34GSW@3041|Chlorophyta 3041|Chlorophyta O Peptidase M16C associated - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_79365_1 1265505.ATUG01000002_gene1567 9.42e-54 182.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42QB5@68525|delta/epsilon subdivisions,2WMMA@28221|Deltaproteobacteria,2MQ1A@213118|Desulfobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_27290_1 1049564.TevJSym_as00280 5.17e-118 347.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1J4E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_156857_1 765913.ThidrDRAFT_1375 1.86e-133 391.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1WWRM@135613|Chromatiales 135613|Chromatiales G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_156857_2 765913.ThidrDRAFT_2825 2.15e-28 113.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_7813_1 768671.ThimaDRAFT_0172 5.74e-125 359.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales 135613|Chromatiales C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_7813_2 765912.Thimo_0468 5.12e-21 86.3 COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1WZ6Q@135613|Chromatiales 135613|Chromatiales S Flavinator of succinate dehydrogenase - - - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 k59_7813_6 472759.Nhal_0560 6.25e-132 384.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales 135613|Chromatiales I PFAM Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_118110_1 1265505.ATUG01000001_gene4509 1.15e-117 350.0 COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2MJEK@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9 k59_92086_3 1209072.ALBT01000038_gene2370 2.51e-18 84.0 COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria,1FHB4@10|Cellvibrio 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_176298_1 296591.Bpro_0829 1.54e-39 145.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,4AACJ@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_14051_1 1123371.ATXH01000022_gene982 3.16e-121 362.0 COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,2GGYN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase,His_biosynth k59_53132_1 1049564.TevJSym_bk00230 1.4e-117 355.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_111551_1 319224.Sputcn32_0171 6.06e-24 94.7 COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,1SYEC@1236|Gammaproteobacteria,2QCFK@267890|Shewanellaceae 1236|Gammaproteobacteria K MerR, DNA binding merR - - ko:K08365 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_118112_1 439235.Dalk_1508 1.13e-28 111.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria,2MJHK@213118|Desulfobacterales 28221|Deltaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_118112_2 443152.MDG893_14243 2.54e-32 115.0 COG2963@1|root,COG2963@2|Bacteria,1N8W3@1224|Proteobacteria,1SEAC@1236|Gammaproteobacteria,46CX7@72275|Alteromonadaceae 1236|Gammaproteobacteria L Helix-turn-helix domain - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_53134_1 279714.FuraDRAFT_1968 1.02e-73 241.0 COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,2VNHI@28216|Betaproteobacteria 28216|Betaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Tail_P2_I k59_92091_2 1049564.TevJSym_ae00050 2.08e-81 247.0 COG4974@1|root,COG4974@2|Bacteria,1QXTU@1224|Proteobacteria 1224|Proteobacteria L integrase family - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_integrase k59_27298_1 1458357.BG58_09410 2.42e-22 104.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VMJI@28216|Betaproteobacteria,1K0C1@119060|Burkholderiaceae 28216|Betaproteobacteria M Rhs_assc_core RHS repeat-associated core domain protein - - - - - - - - - - - - Colicin-DNase,PAAR_motif,RHS,RHS_repeat k59_170016_1 1049564.TevJSym_aw00100 9.27e-138 394.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein dsrO - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_59679_2 1049564.TevJSym_aa01880 1.37e-152 443.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GAF,GAF_2,GGDEF,HD,PAS_4,Response_reg,SpoIIE k59_59679_4 572477.Alvin_1096 1.05e-18 85.1 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1WWVD@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_144063_2 765911.Thivi_3406 3.64e-54 184.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_81726_1 1121405.dsmv_2329 3.53e-72 232.0 COG5000@1|root,COG5000@2|Bacteria,1QWMS@1224|Proteobacteria,43BSR@68525|delta/epsilon subdivisions,2X73I@28221|Deltaproteobacteria,2MPJM@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_10337_1 335543.Sfum_0155 1.29e-80 246.0 COG1774@1|root,COG1774@2|Bacteria,1MZBX@1224|Proteobacteria,42NE3@68525|delta/epsilon subdivisions,2WK98@28221|Deltaproteobacteria,2MQEI@213462|Syntrophobacterales 28221|Deltaproteobacteria S PSP1 C-terminal conserved region - - - - - - - - - - - - PSP1 k59_120938_1 56780.SYN_02123 3.11e-25 99.4 COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,1N731@1224|Proteobacteria,42VC4@68525|delta/epsilon subdivisions,2WRDM@28221|Deltaproteobacteria,2MQMC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Rubredoxin - - - - - - - - - - - - Flavin_Reduct,Rubredoxin k59_120938_2 1121439.dsat_2723 6.52e-36 122.0 COG1773@1|root,COG1773@2|Bacteria,1NES3@1224|Proteobacteria,42VN9@68525|delta/epsilon subdivisions,2WRT2@28221|Deltaproteobacteria,2MCJQ@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - - - - - - - - - - Rubredoxin k59_120938_3 706587.Desti_4439 2e-12 64.7 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - - - - - - - - - - CBS k59_191708_1 177437.HRM2_01760 1.36e-96 296.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2MJ8E@213118|Desulfobacterales 28221|Deltaproteobacteria P Domain of unknown function (DUF3333) pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_191708_2 1121448.DGI_1886 7.8e-11 61.6 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2M8CM@213115|Desulfovibrionales 28221|Deltaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_107489_1 292415.Tbd_1174 4.8e-127 408.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria 28216|Betaproteobacteria G 4-alpha-glucanotransferase treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_3194_1 593750.Metfor_0945 6.96e-14 77.8 COG0642@1|root,arCOG02348@1|root,arCOG02350@1|root,arCOG02353@1|root,arCOG02385@1|root,arCOG02348@2157|Archaea,arCOG02350@2157|Archaea,arCOG02353@2157|Archaea,arCOG02385@2157|Archaea,arCOG06193@2157|Archaea,2Y7U3@28890|Euryarchaeota,2NAXF@224756|Methanomicrobia 2157|Archaea T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - BAT,GAF_2,HATPase_c,HTH_10,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_55133_1 1049564.TevJSym_bs00010 1.74e-63 203.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1J4VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D recombinase XerD - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_146470_1 1291050.JAGE01000001_gene2182 5.07e-90 273.0 COG2801@1|root,COG2801@2|Bacteria,1V8EJ@1239|Firmicutes,24MA4@186801|Clostridia 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,HTH_8,rve k59_127626_1 765912.Thimo_1740 1.88e-69 227.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_178960_1 1121456.ATVA01000012_gene2676 1.27e-31 124.0 COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2M7W6@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,TSP_3,VWA,VWA_2 k59_204574_1 1121405.dsmv_2186 3.82e-19 88.2 COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MHMD@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the ClpX chaperone family - - - - - - - - - - - - AAA_2,ClpB_D2-small k59_204574_2 933262.AXAM01000007_gene2043 4.53e-119 350.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria,2MI1Z@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - ko:K22226 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_191710_1 1049564.TevJSym_aj00080 1.39e-56 182.0 COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1JADW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_191710_2 626887.J057_16760 7.32e-58 185.0 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,4677J@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Thioredoxin-like resA - - - - - - - - - - - AhpC-TSA,Redoxin k59_68739_1 880072.Desac_2147 0.0 1478.0 COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase large chain, oligomerisation - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0661 CPSase_L_D2,CPSase_L_D3,MGS k59_81732_1 1049564.TevJSym_ah00480 2.06e-96 294.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1J5T0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rlmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070041,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_3198_1 1162668.LFE_0371 1.59e-27 113.0 COG0582@1|root,COG0582@2|Bacteria,3J133@40117|Nitrospirae 2|Bacteria L Belongs to the 'phage' integrase family rci - - - - - - - - - - - Phage_integrase k59_172211_1 1238182.C882_4440 4.41e-40 149.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,2JPEV@204441|Rhodospirillales 204441|Rhodospirillales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_185674_1 56780.SYN_00324 1.98e-36 131.0 COG1633@1|root,COG1633@2|Bacteria 2|Bacteria S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin,POR,Rubrerythrin k59_43495_1 59919.PMM0125 1.1e-09 60.8 COG1122@1|root,COG1122@2|Bacteria,1G0FZ@1117|Cyanobacteria,1MM8N@1212|Prochloraceae 1117|Cyanobacteria P ATP-binding component - - - ko:K16786 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_29581_1 631362.Thi970DRAFT_01601 3.9e-203 591.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_68745_1 1408473.JHXO01000007_gene637 2.63e-06 50.1 2DYN6@1|root,34ADX@2|Bacteria,4NW34@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_68745_2 1116472.MGMO_56c00080 3.58e-74 233.0 28NP4@1|root,2ZBP4@2|Bacteria,1NK54@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_178964_1 875328.JDM601_1297 3.45e-23 91.3 COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,23ANR@1762|Mycobacteriaceae 201174|Actinobacteria J 50S ribosomal protein L31 rpmE GO:0008150,GO:0040007 - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_178964_2 553385.JEMF01000019_gene1022 1.12e-06 51.6 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1XHU3@135619|Oceanospirillales 135619|Oceanospirillales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_16127_1 1397527.Q670_03300 8.41e-26 106.0 COG1488@1|root,COG1488@2|Bacteria,1MWA2@1224|Proteobacteria,1RPPA@1236|Gammaproteobacteria,1XN1B@135619|Oceanospirillales 135619|Oceanospirillales H Nicotinate phosphoribosyltransferase (NAPRTase) family - - 2.4.2.12 ko:K03462 ko00760,ko01100,ko04621,map00760,map01100,map04621 - R01271 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_16127_2 270374.MELB17_10618 1.42e-09 56.2 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,46851@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3436 Transposase and inactivated derivatives - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_62354_1 1121035.AUCH01000009_gene868 2.92e-09 57.8 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,2KV81@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_62354_2 1049564.TevJSym_bt00150 2.91e-43 147.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria 1236|Gammaproteobacteria O O-Methyltransferase pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_197754_2 1049564.TevJSym_af00200 3.83e-06 47.4 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1J4G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 GATase,GMP_synt_C,NAD_synthase k59_120964_1 999423.HMPREF9161_01721 5.72e-35 139.0 COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,4H2XV@909932|Negativicutes 909932|Negativicutes N Flagellar biosynthesis flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_107500_1 335543.Sfum_3724 1.21e-145 431.0 COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM DAHP synthetase I KDSA - - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,DAHP_synth_1,PDT k59_139500_3 1049564.TevJSym_bw00080 6.55e-07 50.8 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J5FV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_139500_5 1121007.AUML01000014_gene2883 3.59e-75 239.0 COG2175@1|root,COG2175@2|Bacteria,4NTK5@976|Bacteroidetes 976|Bacteroidetes Q Taurine catabolism dioxygenase TauD, TfdA family - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_139500_6 502025.Hoch_6016 1.35e-20 92.8 2CJNX@1|root,32SAE@2|Bacteria,1P2EN@1224|Proteobacteria,43DZ2@68525|delta/epsilon subdivisions,2WZ8W@28221|Deltaproteobacteria,2Z1KR@29|Myxococcales 28221|Deltaproteobacteria S FcoT-like thioesterase domain - - - - - - - - - - - - FcoT k59_139500_7 1463825.JNXC01000006_gene2163 8.1e-25 110.0 COG2175@1|root,COG2175@2|Bacteria,2HE90@201174|Actinobacteria,4E0QB@85010|Pseudonocardiales 201174|Actinobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_139500_9 1049564.TevJSym_bw00080 9.74e-124 365.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J5FV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_49144_2 1201293.AKXQ01000015_gene1424 1.27e-18 94.7 COG2199@1|root,COG3706@2|Bacteria,1N7HG@1224|Proteobacteria,1S2NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - GGDEF k59_49144_4 1049564.TevJSym_an00700 1e-23 99.8 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1J546@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ytfN GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_185679_1 1049564.TevJSym_ab02010 2.76e-32 124.0 COG1527@1|root,COG1527@2|Bacteria,1R7PV@1224|Proteobacteria,1S0C2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C (C AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_185679_2 765912.Thimo_1493 2.09e-30 111.0 2BU1D@1|root,32PA2@2|Bacteria,1N4TV@1224|Proteobacteria,1SBJ8@1236|Gammaproteobacteria,1WZ1H@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_62358_2 936596.HMPREF1495_1674 1.82e-07 50.1 COG2929@1|root,COG2929@2|Bacteria,1VE89@1239|Firmicutes,24N45@186801|Clostridia 186801|Clostridia S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - - - - - - - - - - BrnT_toxin k59_127646_1 335543.Sfum_2756 8.02e-50 177.0 COG0707@1|root,COG1413@1|root,COG0707@2|Bacteria,COG1413@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2MRPC@213462|Syntrophobacterales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_3209_1 1049564.TevJSym_aw00140 1.56e-118 343.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - - - - - - - - - - - Nitrate_red_gam k59_3209_2 2340.JV46_15470 1.23e-67 205.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1J6P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system tusE GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_55134_2 1049564.TevJSym_au00360 0.0 930.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1J5M4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_81747_1 882.DVU_2966 1.09e-15 77.4 COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria,2MH8W@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_81747_2 879212.DespoDRAFT_03292 4.02e-10 61.6 COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ2F@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS_8,PAS_9,Response_reg k59_133578_2 83406.HDN1F_01990 3.29e-25 98.6 COG3436@1|root,COG3436@2|Bacteria,1N638@1224|Proteobacteria,1SFHC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L IS66 Orf2 like protein - - - - - - - - - - - - TnpB_IS66 k59_133578_3 1535422.ND16A_0183 2.49e-157 466.0 COG3316@1|root,COG3316@2|Bacteria 1535422.ND16A_0183|- - - - - - - - - - - - - - - - k59_36592_2 399739.Pmen_4119 2.16e-62 207.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RPVU@1236|Gammaproteobacteria,1YE1K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain creC GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07641,ko:K07711 ko02020,ko02024,map02020,map02024 M00449,M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,dCache_3,sCache_3_2 k59_88116_1 1411685.U062_01922 5.3e-23 103.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1J5PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_88116_2 713586.KB900536_gene446 3.47e-22 97.1 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1WY25@135613|Chromatiales 135613|Chromatiales S protein conserved in bacteria - - - - - - - - - - - - TPR_21 k59_81855_1 1453501.JELR01000002_gene1350 6.66e-10 59.3 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,465PA@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0553 Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_81855_2 1453501.JELR01000002_gene1351 0.0 2090.0 COG1002@1|root,COG1002@2|Bacteria,1MWRH@1224|Proteobacteria,1RRRA@1236|Gammaproteobacteria,46B5M@72275|Alteromonadaceae 1236|Gammaproteobacteria V Type II restriction enzyme, methylase - - - - - - - - - - - - - k59_81855_3 1453501.JELR01000002_gene1352 0.0 2054.0 COG1200@1|root,COG1200@2|Bacteria,1QWSU@1224|Proteobacteria,1T3V6@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL Helicase conserved C-terminal domain - - - - - - - - - - - - Helicase_C k59_81855_4 314285.KT71_11394 1.14e-192 558.0 COG0210@1|root,COG0210@2|Bacteria,1MXSI@1224|Proteobacteria,1TCJ8@1236|Gammaproteobacteria,1JBJW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Nuclease-related domain - - - - - - - - - - - - NERD,UvrD_C_2 k59_81855_5 232721.Ajs_2204 0.0 1021.0 28HBW@1|root,2Z7NV@2|Bacteria,1N8Z2@1224|Proteobacteria,2VITM@28216|Betaproteobacteria,4AC15@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1998) - - - - - - - - - - - - DUF1998 k59_81855_6 189753.AXAS01000045_gene6079 6.74e-72 227.0 COG1502@1|root,COG1502@2|Bacteria,1NXTE@1224|Proteobacteria,2UR7F@28211|Alphaproteobacteria,3K2MY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Phospholipase D Active site motif - - - - - - - - - - - - PLDc_2 k59_139681_1 1322246.BN4_12484 3.12e-27 121.0 COG4191@1|root,COG4585@1|root,COG5000@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria,COG5000@2|Bacteria,1RB4Z@1224|Proteobacteria,42SHV@68525|delta/epsilon subdivisions,2X7QP@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,PAS_9 k59_23560_1 1049564.TevJSym_aw00590 1.72e-33 120.0 COG1580@1|root,COG1580@2|Bacteria,1N2N9@1224|Proteobacteria,1SAF0@1236|Gammaproteobacteria,1J6I3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_23560_2 1049564.TevJSym_aw00580 1.88e-45 156.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1J4Q8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_127843_1 530564.Psta_0173 9.9e-58 201.0 COG0501@1|root,COG3170@1|root,COG0501@2|Bacteria,COG3170@2|Bacteria,2IXM0@203682|Planctomycetes 203682|Planctomycetes O Zn-dependent protease with chaperone function - - - - - - - - - - - - Peptidase_M48 k59_152899_2 1049564.TevJSym_ar00240 3.75e-51 172.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1J5R9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_68956_1 886293.Sinac_5899 8.44e-67 219.0 COG4584@1|root,COG4584@2|Bacteria,2J4C3@203682|Planctomycetes 203682|Planctomycetes L PFAM Integrase core domain - - - - - - - - - - - - rve k59_100762_1 589873.EP13_03965 1.53e-20 94.0 COG3209@1|root,COG3209@2|Bacteria,1N3F8@1224|Proteobacteria,1SBPN@1236|Gammaproteobacteria,46CI6@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS k59_3355_2 1408419.JHYG01000001_gene1986 8.25e-40 147.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_197918_1 404589.Anae109_2221 9.83e-198 594.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_36599_1 1125863.JAFN01000001_gene3061 6.01e-85 264.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3395 Aldedh k59_18860_1 1174528.JH992890_gene581 1.15e-129 392.0 COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,1JHHS@1189|Stigonemataceae 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,HNH,RVT_1,RVT_N k59_162035_1 555779.Dthio_PD0080 1.28e-35 131.0 COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,42TNA@68525|delta/epsilon subdivisions,2WR5E@28221|Deltaproteobacteria,2MGBS@213115|Desulfovibrionales 28221|Deltaproteobacteria L integrase domain protein SAM domain protein - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_162035_2 1121396.KB892990_gene4484 1.25e-47 163.0 COG0582@1|root,COG0582@2|Bacteria,1NE6N@1224|Proteobacteria,42WWJ@68525|delta/epsilon subdivisions,2WSVR@28221|Deltaproteobacteria,2MNW7@213118|Desulfobacterales 28221|Deltaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_155267_1 1232410.KI421418_gene2358 3.72e-52 178.0 COG2303@1|root,COG2365@1|root,COG2303@2|Bacteria,COG2365@2|Bacteria,1RGE7@1224|Proteobacteria,42U1M@68525|delta/epsilon subdivisions,2WQE0@28221|Deltaproteobacteria,43W3C@69541|Desulfuromonadales 28221|Deltaproteobacteria T Dual specificity phosphatase, catalytic domain - - - - - - - - - - - - Y_phosphatase2 k59_174317_1 933262.AXAM01000036_gene2181 7.83e-65 223.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MI3P@213118|Desulfobacterales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_155268_1 1049564.TevJSym_ac00320 3.43e-42 153.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,1RQCS@1236|Gammaproteobacteria,1J71N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_116345_2 933262.AXAM01000085_gene1060 4.12e-15 76.6 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2MHW1@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF2344,Radical_SAM k59_116345_3 1121405.dsmv_3267 2.05e-35 133.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales 28221|Deltaproteobacteria J ribonuclease Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_168079_1 335543.Sfum_2077 7.54e-272 757.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria,2MR1W@213462|Syntrophobacterales 28221|Deltaproteobacteria I AMP-dependent synthetase and ligase - - 6.2.1.1,6.2.1.32 ko:K01895,ko:K08295 ko00010,ko00620,ko00627,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00627,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R00982,R01354 RC00004,RC00012,RC00043,RC00070,RC00174,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_103092_1 1071073.KI530549_gene3535 1.52e-22 102.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAXK@1386|Bacillus 91061|Bacilli C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively - - - - - - - - - - - - Aldedh k59_5605_1 1540257.JQMW01000009_gene2681 4e-34 132.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,36F7Z@31979|Clostridiaceae 186801|Clostridia L Reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_51818_3 1049564.TevJSym_aj00220 1.37e-85 261.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1J4NR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_181262_1 998674.ATTE01000001_gene4209 2.78e-86 267.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,463KW@72273|Thiotrichales 72273|Thiotrichales I Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,FA_desaturase k59_194191_2 1298593.TOL_0762 4.7e-43 145.0 COG0834@1|root,COG0834@2|Bacteria,1RHMR@1224|Proteobacteria 1224|Proteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - - - - - - - - - - - k59_32191_1 96561.Dole_0729 2.34e-41 136.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MKKE@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_32191_2 1121405.dsmv_3570 1.66e-33 125.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_116356_1 1049564.TevJSym_au00220 7.28e-220 628.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_142297_1 1122201.AUAZ01000022_gene3082 3.21e-156 443.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,1RR82@1236|Gammaproteobacteria,466BC@72275|Alteromonadaceae 1236|Gammaproteobacteria D The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_18880_1 393305.YE1177 1.2e-18 90.5 COG3846@1|root,COG3846@2|Bacteria,1MVFD@1224|Proteobacteria,1RNAC@1236|Gammaproteobacteria,41HBW@629|Yersinia 1236|Gammaproteobacteria U TrbL/VirB6 plasmid conjugal transfer protein trbL - - ko:K07344 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - TrbL k59_77232_1 706587.Desti_1609 6.98e-79 263.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MQ8P@213462|Syntrophobacterales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_116360_1 195250.CM001776_gene949 1.19e-101 327.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_77236_1 933262.AXAM01000029_gene2741 3.14e-71 235.0 COG0493@1|root,COG2878@1|root,COG0493@2|Bacteria,COG2878@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2WIVF@28221|Deltaproteobacteria,2MIVJ@213118|Desulfobacterales 28221|Deltaproteobacteria C Fe-S cluster domain protein - - - - - - - - - - - - FeS,Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_77236_2 1265505.ATUG01000002_gene2205 5.93e-14 68.6 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,42MCM@68525|delta/epsilon subdivisions,2WKRE@28221|Deltaproteobacteria,2MJ7J@213118|Desulfobacterales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_32203_1 1121405.dsmv_0072 5.02e-119 352.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria,2MIUA@213118|Desulfobacterales 28221|Deltaproteobacteria C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) sucB - 2.3.1.12,2.3.1.61 ko:K00627,ko:K00658 ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00307 R00209,R02569,R02570,R02571,R08549 RC00004,RC02727,RC02742,RC02833,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2766 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_90594_5 1236541.BALL01000011_gene1723 1.23e-33 128.0 2C3X5@1|root,32RCX@2|Bacteria,1RKW4@1224|Proteobacteria,1S73W@1236|Gammaproteobacteria,2QC0X@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_155274_2 1121015.N789_13715 2.33e-43 177.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1R6BM@1224|Proteobacteria,1RRQG@1236|Gammaproteobacteria,1X447@135614|Xanthomonadales 135614|Xanthomonadales T Response regulator receiver - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_155274_3 983545.Glaag_0929 8.81e-44 165.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,465BB@72275|Alteromonadaceae 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_200149_1 1499967.BAYZ01000028_gene1306 7.04e-20 86.3 COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid transport system / permease component livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_57505_2 1304885.AUEY01000072_gene1710 3.41e-49 165.0 COG2605@1|root,COG2605@2|Bacteria,1QW1A@1224|Proteobacteria,42N0X@68525|delta/epsilon subdivisions,2WK4R@28221|Deltaproteobacteria,2MKF9@213118|Desulfobacterales 28221|Deltaproteobacteria S GHMP kinases C terminal - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_77573_3 595494.Tola_2854 4.63e-36 127.0 COG3093@1|root,COG3093@2|Bacteria,1NHM7@1224|Proteobacteria,1ST35@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26 k59_77573_4 1122211.JMLW01000017_gene1555 1.43e-28 110.0 2DHBG@1|root,2ZZ37@2|Bacteria,1RGFW@1224|Proteobacteria,1S5S9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - SecB k59_77573_5 357809.Cphy_2161 3.53e-48 159.0 COG3837@1|root,COG3837@2|Bacteria,1V9M6@1239|Firmicutes,24HEN@186801|Clostridia,221B6@1506553|Lachnoclostridium 186801|Clostridia S Cupin domain - - - - - - - - - - - - Cupin_2 k59_77573_6 509191.AEDB02000034_gene2315 8.64e-56 207.0 COG0296@1|root,COG2730@1|root,COG3291@1|root,COG4193@1|root,COG4733@1|root,COG0296@2|Bacteria,COG2730@2|Bacteria,COG3291@2|Bacteria,COG4193@2|Bacteria,COG4733@2|Bacteria,1U53B@1239|Firmicutes,25KDY@186801|Clostridia,3WNUI@541000|Ruminococcaceae 186801|Clostridia G Carbohydrate binding module (family 6) - - - - - - - - - - - - CBM_6,Cellulase,Dockerin_1 k59_168419_1 177437.HRM2_20940 6.83e-143 424.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_103357_1 1173028.ANKO01000112_gene4887 1.37e-23 91.7 COG2336@1|root,COG2336@2|Bacteria,1G908@1117|Cyanobacteria,1HDBB@1150|Oscillatoriales 1117|Cyanobacteria T SpoVT / AbrB like domain - - - - - - - - - - - - MazE_antitoxin k59_103357_2 543728.Vapar_4244 4e-30 112.0 COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,2VTKH@28216|Betaproteobacteria,4AESN@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM death-on-curing family protein doc - - ko:K07341 - - - - ko00000,ko02048 - - - Fic k59_103357_3 911045.PSE_3217 5.55e-18 81.6 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_155501_7 1397527.Q670_03300 3.69e-217 612.0 COG1488@1|root,COG1488@2|Bacteria,1MWA2@1224|Proteobacteria,1RPPA@1236|Gammaproteobacteria,1XN1B@135619|Oceanospirillales 135619|Oceanospirillales H Nicotinate phosphoribosyltransferase (NAPRTase) family - - 2.4.2.12 ko:K03462 ko00760,ko01100,ko04621,map00760,map01100,map04621 - R01271 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_5830_1 36874.HQ34_03620 5.46e-47 161.0 COG1212@1|root,COG1212@2|Bacteria,4NG4B@976|Bacteroidetes,2FMHD@200643|Bacteroidia,22XG8@171551|Porphyromonadaceae 976|Bacteroidetes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_168432_1 331869.BAL199_18761 1.61e-19 91.7 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TRTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_103361_1 1121405.dsmv_1764 1.47e-108 334.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MIQB@213118|Desulfobacterales 28221|Deltaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_77581_1 706587.Desti_4731 1.67e-05 46.2 COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Metal-dependent phosphohydrolase, HD - - - ko:K06951 - - - - ko00000 - - - HD k59_77581_2 1229205.BUPH_08182 0.00059 43.5 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2VI52@28216|Betaproteobacteria,1K6AG@119060|Burkholderiaceae 28216|Betaproteobacteria C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_149070_1 1122963.AUHB01000006_gene2565 1.5e-20 89.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,36XQ9@31993|Methylocystaceae 28211|Alphaproteobacteria I Phosphatidylserine decarboxylase psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_149070_2 1123371.ATXH01000012_gene1441 4.99e-29 111.0 COG1183@1|root,COG1183@2|Bacteria,2GHN6@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria I CDP-alcohol phosphatidyltransferase - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_19194_2 1049564.TevJSym_av00330 8.36e-30 119.0 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1JB68@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_149071_1 335543.Sfum_1219 4.22e-105 314.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MQW6@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_5844_1 926561.KB900618_gene287 1.78e-64 213.0 COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,3WA61@53433|Halanaerobiales 186801|Clostridia S pyridine nucleotide-disulphide oxidoreductase dimerisation - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_19201_1 933262.AXAM01000001_gene422 5.27e-43 142.0 COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria,2MKPA@213118|Desulfobacterales 28221|Deltaproteobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_103379_1 935567.JAES01000017_gene2432 2.7e-29 115.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_174624_1 1049564.TevJSym_an00220 1.55e-26 106.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1J4J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_103380_1 335543.Sfum_3241 5.04e-56 179.0 arCOG05253@1|root,31CTK@2|Bacteria,1RIYS@1224|Proteobacteria,42T7T@68525|delta/epsilon subdivisions,2WP9R@28221|Deltaproteobacteria,2MQHS@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_155525_1 6211.A0A068XYS8 2.14e-07 58.5 COG2217@1|root,KOG0207@2759|Eukaryota,38BU3@33154|Opisthokonta,3BAGR@33208|Metazoa,3CT9U@33213|Bilateria 33208|Metazoa P copper-exporting ATPase activity ATP7B GO:0000041,GO:0000139,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0000902,GO:0000904,GO:0001101,GO:0001501,GO:0001505,GO:0001568,GO:0001666,GO:0001701,GO:0001775,GO:0001836,GO:0001889,GO:0001942,GO:0001944,GO:0001974,GO:0002009,GO:0002082,GO:0002164,GO:0002252,GO:0002263,GO:0002285,GO:0002286,GO:0002287,GO:0002292,GO:0002293,GO:0002294,GO:0002366,GO:0002376,GO:0002520,GO:0002521,GO:0003674,GO:0003824,GO:0004008,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005773,GO:0005774,GO:0005783,GO:0005794,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0005902,GO:0005903,GO:0005911,GO:0005923,GO:0006082,GO:0006139,GO:0006140,GO:0006163,GO:0006464,GO:0006520,GO:0006568,GO:0006570,GO:0006576,GO:0006584,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006801,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006874,GO:0006875,GO:0006878,GO:0006882,GO:0006915,GO:0006950,GO:0006955,GO:0006979,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007589,GO:0007591,GO:0007593,GO:0007595,GO:0007610,GO:0007623,GO:0007626,GO:0008047,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0008270,GO:0008284,GO:0008324,GO:0008361,GO:0008544,GO:0008637,GO:0009058,GO:0009059,GO:0009072,GO:0009100,GO:0009101,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009308,GO:0009628,GO:0009636,GO:0009653,GO:0009712,GO:0009713,GO:0009719,GO:0009725,GO:0009790,GO:0009791,GO:0009792,GO:0009888,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0010042,GO:0010043,GO:0010155,GO:0010243,GO:0010273,GO:0010288,GO:0010468,GO:0010591,GO:0010592,GO:0010941,GO:0010959,GO:0012501,GO:0012505,GO:0012506,GO:0014070,GO:0014074,GO:0014910,GO:0014911,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015677,GO:0015679,GO:0015680,GO:0016020,GO:0016021,GO:0016043,GO:0016323,GO:0016324,GO:0016358,GO:0016462,GO:0016530,GO:0016531,GO:0016532,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017016,GO:0017048,GO:0017076,GO:0017111,GO:0017144,GO:0018193,GO:0018205,GO:0018958,GO:0019219,GO:0019220,GO:0019222,GO:0019430,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019725,GO:0019752,GO:0019829,GO:0019899,GO:0021533,GO:0021549,GO:0021575,GO:0021587,GO:0021680,GO:0021692,GO:0021694,GO:0021695,GO:0021696,GO:0021697,GO:0021700,GO:0021702,GO:0021859,GO:0021860,GO:0021872,GO:0021879,GO:0021884,GO:0021953,GO:0021954,GO:0022008,GO:0022037,GO:0022404,GO:0022405,GO:0022607,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0022898,GO:0023052,GO:0030001,GO:0030003,GO:0030030,GO:0030054,GO:0030097,GO:0030098,GO:0030133,GO:0030135,GO:0030136,GO:0030139,GO:0030140,GO:0030141,GO:0030154,GO:0030182,GO:0030198,GO:0030199,GO:0030217,GO:0030234,GO:0030323,GO:0030324,GO:0030334,GO:0030335,GO:0030554,GO:0030659,GO:0030666,GO:0030670,GO:0030879,GO:0030900,GO:0030902,GO:0031069,GO:0031090,GO:0031175,GO:0031224,GO:0031226,GO:0031252,GO:0031253,GO:0031267,GO:0031323,GO:0031344,GO:0031346,GO:0031410,GO:0031526,GO:0031982,GO:0031984,GO:0032025,GO:0032409,GO:0032412,GO:0032501,GO:0032502,GO:0032535,GO:0032553,GO:0032555,GO:0032559,GO:0032588,GO:0032767,GO:0032879,GO:0032989,GO:0032990,GO:0033554,GO:0034220,GO:0034599,GO:0034614,GO:0034641,GO:0034645,GO:0034756,GO:0034757,GO:0034759,GO:0034760,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0035295,GO:0035434,GO:0035639,GO:0035710,GO:0036094,GO:0036119,GO:0036120,GO:0036211,GO:0036293,GO:0036294,GO:0036477,GO:0040012,GO:0040017,GO:0042093,GO:0042110,GO:0042127,GO:0042133,GO:0042221,GO:0042303,GO:0042325,GO:0042335,GO:0042414,GO:0042415,GO:0042417,GO:0042421,GO:0042423,GO:0042428,GO:0042430,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0042633,GO:0042981,GO:0042995,GO:0043005,GO:0043009,GO:0043025,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043200,GO:0043204,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043271,GO:0043296,GO:0043367,GO:0043412,GO:0043434,GO:0043436,GO:0043467,GO:0043473,GO:0043492,GO:0043523,GO:0043524,GO:0043588,GO:0043682,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044093,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045121,GO:0045177,GO:0045321,GO:0045335,GO:0045793,GO:0046034,GO:0046189,GO:0046483,GO:0046631,GO:0046632,GO:0046649,GO:0046677,GO:0046683,GO:0046686,GO:0046688,GO:0046872,GO:0046873,GO:0046903,GO:0046907,GO:0046914,GO:0046915,GO:0046916,GO:0048066,GO:0048067,GO:0048085,GO:0048251,GO:0048286,GO:0048365,GO:0048468,GO:0048471,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048584,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048730,GO:0048731,GO:0048732,GO:0048771,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0048878,GO:0050678,GO:0050679,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050878,GO:0050896,GO:0051020,GO:0051049,GO:0051051,GO:0051087,GO:0051128,GO:0051130,GO:0051171,GO:0051174,GO:0051179,GO:0051208,GO:0051216,GO:0051234,GO:0051235,GO:0051270,GO:0051272,GO:0051341,GO:0051353,GO:0051541,GO:0051542,GO:0051591,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055069,GO:0055070,GO:0055074,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0060003,GO:0060255,GO:0060322,GO:0060429,GO:0060491,GO:0060541,GO:0060548,GO:0061008,GO:0061448,GO:0061687,GO:0062012,GO:0065007,GO:0065008,GO:0065009,GO:0070160,GO:0070482,GO:0070848,GO:0070887,GO:0071229,GO:0071230,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0071279,GO:0071280,GO:0071281,GO:0071284,GO:0071287,GO:0071310,GO:0071363,GO:0071417,GO:0071450,GO:0071451,GO:0071453,GO:0071456,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0072503,GO:0072507,GO:0072521,GO:0072593,GO:0080090,GO:0080134,GO:0085029,GO:0090066,GO:0090662,GO:0097159,GO:0097164,GO:0097190,GO:0097237,GO:0097367,GO:0097435,GO:0097458,GO:0097501,GO:0097708,GO:0098588,GO:0098589,GO:0098590,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:0098772,GO:0098773,GO:0098791,GO:0098805,GO:0098857,GO:0098858,GO:0098862,GO:0098869,GO:0099131,GO:0099132,GO:0099503,GO:0120025,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0140104,GO:1900542,GO:1901135,GO:1901137,GO:1901160,GO:1901214,GO:1901215,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901615,GO:1901617,GO:1901652,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902743,GO:1902745,GO:1903034,GO:1903036,GO:1903136,GO:1903578,GO:1904062,GO:1904063,GO:1904732,GO:1904752,GO:1904754,GO:1904959,GO:1990169,GO:1990637,GO:1990748,GO:2000145,GO:2000147 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_103381_1 671143.DAMO_1522 7.16e-33 124.0 COG2267@1|root,COG2267@2|Bacteria,2NPTF@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family mhpC - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 k59_168462_2 765913.ThidrDRAFT_0127 3.26e-38 134.0 COG2105@1|root,COG2105@2|Bacteria,1RH3X@1224|Proteobacteria,1S68T@1236|Gammaproteobacteria,1WYAJ@135613|Chromatiales 135613|Chromatiales S PFAM AIG2-like - - - - - - - - - - - - GGACT k59_207043_1 1007105.PT7_3162 4.62e-216 611.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,3T1JS@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the mannose-6-phosphate isomerase type 2 family cpsB - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_57828_1 1307759.JOMJ01000003_gene1946 2.28e-19 82.0 COG0662@1|root,COG0662@2|Bacteria,1Q8SA@1224|Proteobacteria,432SV@68525|delta/epsilon subdivisions,2WY9Y@28221|Deltaproteobacteria,2MF5K@213115|Desulfovibrionales 28221|Deltaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_57828_2 1179778.PMM47T1_11417 8.26e-26 102.0 COG1443@1|root,COG1443@2|Bacteria,1P8AM@1224|Proteobacteria,1RQA3@1236|Gammaproteobacteria 1236|Gammaproteobacteria I NUDIX hydrolase yfcD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0565 NUDIX k59_5879_1 246197.MXAN_4000 3.72e-55 199.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_155538_1 1131462.DCF50_p2154 4.85e-09 58.2 COG5001@1|root,COG5001@2|Bacteria,1UNXG@1239|Firmicutes,25H4Z@186801|Clostridia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF k59_5885_1 379731.PST_2036 1.01e-77 254.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1Z0JC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnD GO:0003674,GO:0003824,GO:0003994,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575 4.2.1.117,4.2.1.3 ko:K01681,ko:K20455 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900,R11263 RC00497,RC00498,RC00618,RC01152 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_5885_2 93220.LV28_05265 8.79e-09 55.5 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VHJZ@28216|Betaproteobacteria,1K1TX@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the citrate synthase family prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_174652_1 397291.C804_03307 3.36e-22 97.4 COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24BUG@186801|Clostridia,27MU0@186928|unclassified Lachnospiraceae 186801|Clostridia G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_207048_1 335543.Sfum_1747 5.48e-46 153.0 2DWSR@1|root,341Q6@2|Bacteria,1Q538@1224|Proteobacteria,430G3@68525|delta/epsilon subdivisions,2WVK2@28221|Deltaproteobacteria,2MRYW@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_207048_2 1121405.dsmv_2460 2.54e-05 45.8 COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1R05R@1224|Proteobacteria,42QEV@68525|delta/epsilon subdivisions,2WMBG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_103406_1 1356854.N007_19685 9.05e-54 185.0 COG3385@1|root,COG3385@2|Bacteria,1TSH6@1239|Firmicutes,4HEX8@91061|Bacilli 91061|Bacilli L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_57838_1 390235.PputW619_3331 5.85e-05 50.4 28H5A@1|root,2Z7HX@2|Bacteria,1PFKH@1224|Proteobacteria,1RY1T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Integrating conjugative element protein - - - - - - - - - - - - TraU k59_57838_3 314285.KT71_17921 1.17e-23 101.0 COG3451@1|root,COG3451@2|Bacteria,1MUEN@1224|Proteobacteria,1RPAY@1236|Gammaproteobacteria,1J9V0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U F pilus assembly Type-IV secretion system for plasmid transfer - - - - - - - - - - - - DUF87,TraC_F_IV k59_57840_1 977880.pRALTA_0502 1.11e-31 124.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K6IH@119060|Burkholderiaceae 28216|Betaproteobacteria L Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_19244_1 443143.GM18_1091 2.27e-11 62.4 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42PGG@68525|delta/epsilon subdivisions,2WIM1@28221|Deltaproteobacteria,43S3U@69541|Desulfuromonadales 28221|Deltaproteobacteria H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_5911_1 237368.SCABRO_01324 4.47e-45 156.0 COG3267@1|root,COG3267@2|Bacteria,2IZGI@203682|Planctomycetes 203682|Planctomycetes U Type II secretory pathway component ExeA - - - - - - - - - - - - AAA_22 k59_174668_1 443144.GM21_0435 1.1e-70 239.0 COG1361@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TIGRFAM conserved repeat domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_111906_1 331678.Cphamn1_2310 5.79e-64 208.0 COG1609@1|root,COG1609@2|Bacteria 2|Bacteria K purine nucleotide biosynthetic process - - 5.3.1.12 ko:K01812,ko:K02529,ko:K16210 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000,ko02000,ko03000 2.A.2.5 - - DDE_Tnp_ISAZ013,Peripla_BP_3 k59_8126_1 335543.Sfum_0063 4.43e-94 288.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2MQ76@213462|Syntrophobacterales 28221|Deltaproteobacteria E TIGRFAM acetylornithine and succinylornithine argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_0204 Aminotran_3 k59_202682_1 1049564.TevJSym_at00080 1.75e-216 636.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_150890_1 690850.Desaf_1234 4.21e-102 313.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M915@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_144452_1 223926.28806096 4.4e-10 60.8 COG3772@1|root,COG3772@2|Bacteria,1N30X@1224|Proteobacteria,1SA8Q@1236|Gammaproteobacteria,1XY6Z@135623|Vibrionales 135623|Vibrionales S lysozyme VP1109 - - - - - - - - - - - - k59_144452_2 1336233.JAEH01000022_gene2137 7.82e-86 261.0 COG3409@1|root,COG3409@2|Bacteria,1PF8M@1224|Proteobacteria,1TKVK@1236|Gammaproteobacteria,2QE3F@267890|Shewanellaceae 1236|Gammaproteobacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - - k59_144452_7 765910.MARPU_03895 5.27e-114 332.0 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1X0JP@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate - - 4.1.99.12 ko:K02858 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R07281 RC01792,RC01815 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase k59_34125_1 754027.HMPREF9554_01606 4.17e-44 157.0 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2J5CT@203691|Spirochaetes 203691|Spirochaetes T HD domain protein - - - - - - - - - - - - GAF,HD k59_157215_1 1121403.AUCV01000006_gene403 2.05e-22 100.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2MHZA@213118|Desulfobacterales 28221|Deltaproteobacteria S CBS domain - - - - - - - - - - - - CBS,DUF21 k59_92515_1 933262.AXAM01000004_gene2362 1.52e-66 206.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,42SMU@68525|delta/epsilon subdivisions,2WP4P@28221|Deltaproteobacteria,2MK67@213118|Desulfobacterales 28221|Deltaproteobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_195762_1 1121456.ATVA01000011_gene1354 2.49e-54 183.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2M9HU@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_176718_1 177437.HRM2_36270 1.91e-14 67.4 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MK4M@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_176718_2 589865.DaAHT2_1452 7.35e-52 171.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2MJKX@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_40716_1 1049564.TevJSym_ao00190 4.51e-144 412.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1J5RX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074 Metallophos k59_124985_1 1121396.KB892902_gene2267 1.76e-80 253.0 COG3023@1|root,COG3023@2|Bacteria,1PD4C@1224|Proteobacteria,42PQW@68525|delta/epsilon subdivisions,2WK9V@28221|Deltaproteobacteria,2MI3K@213118|Desulfobacterales 28221|Deltaproteobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 k59_202692_1 377629.TERTU_2966 2.56e-55 188.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,2PMJY@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L Exonuclease C-terminal sbcB GO:0000175,GO:0000287,GO:0000738,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008852,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016829,GO:0016835,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0051575,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_8135_1 1121405.dsmv_3068 2.39e-69 216.0 COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42RVI@68525|delta/epsilon subdivisions,2WNVE@28221|Deltaproteobacteria,2MNBC@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - ko:K04767 - - - - ko00000 - - - CBS k59_195763_1 1123508.JH636442_gene3961 1.86e-17 87.8 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2IXFD@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_27594_1 1049564.TevJSym_al00520 1.79e-92 283.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1J578@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG4591 ABC-type transport system, involved in lipoprotein release, permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_27594_2 1049564.TevJSym_al00510 2.18e-49 163.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1J53N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778 - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_47013_2 391615.ABSJ01000029_gene1953 4.04e-26 117.0 COG1040@1|root,COG1040@2|Bacteria,1REX9@1224|Proteobacteria,1S568@1236|Gammaproteobacteria 1236|Gammaproteobacteria S competence protein - - - - - - - - - - - - - k59_47013_3 1005048.CFU_1160 8.57e-61 214.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VPBJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid k59_47013_4 1168065.DOK_15534 2.2e-92 285.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1J5A8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_73036_1 96561.Dole_0333 1.25e-30 119.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales 28221|Deltaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_131775_1 344747.PM8797T_03389 1.09e-122 367.0 COG2230@1|root,COG2230@2|Bacteria,2IYIJ@203682|Planctomycetes 203682|Planctomycetes M COG2230 Cyclopropane fatty acid synthase and related - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_92839_1 1049564.TevJSym_am00390 0.0 1112.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J5C9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_92839_3 1049564.TevJSym_am00410 1.02e-25 101.0 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1J715@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG4968 Tfp pilus assembly protein PilE - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_79904_1 880072.Desac_0995 4.93e-19 85.1 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_21501_1 439235.Dalk_4002 1.3e-47 164.0 COG0232@1|root,COG0232@2|Bacteria,1R6QQ@1224|Proteobacteria,42M0H@68525|delta/epsilon subdivisions,2WJ33@28221|Deltaproteobacteria,2MHN1@213118|Desulfobacterales 28221|Deltaproteobacteria F SMART metal-dependent phosphohydrolase HD region - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_21501_2 933262.AXAM01000005_gene2454 2.4e-125 363.0 COG0189@1|root,COG0189@2|Bacteria,1MWQA@1224|Proteobacteria,43B1R@68525|delta/epsilon subdivisions,2X6FW@28221|Deltaproteobacteria,2MJ6I@213118|Desulfobacterales 28221|Deltaproteobacteria HJ RimK-like ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_151131_1 1121445.ATUZ01000015_gene1924 5.77e-19 91.3 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2M928@213115|Desulfovibrionales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF2344,Radical_SAM k59_14537_1 335543.Sfum_1550 4.56e-166 503.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_144734_2 269799.Gmet_1210 1.74e-127 383.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cytochrome c peroxidase - - - - - - - - - - - - CCP_MauG,Cytochrom_C k59_144734_3 317025.Tcr_0783 1.27e-169 488.0 COG0225@1|root,COG0229@1|root,COG0526@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,COG0526@2|Bacteria,1MVUS@1224|Proteobacteria,1T0T1@1236|Gammaproteobacteria,460U4@72273|Thiotrichales 72273|Thiotrichales CO Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR,Thioredoxin_2 k59_125293_1 1232437.KL662060_gene4117 2.41e-20 87.0 COG0500@1|root,COG2226@2|Bacteria,1RK08@1224|Proteobacteria,42TCK@68525|delta/epsilon subdivisions,2X628@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Fibrillarin - - - - - - - - - - - - Methyltransf_25 k59_73040_1 1121405.dsmv_3247 7.4e-113 333.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2MI6H@213118|Desulfobacterales 28221|Deltaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_98886_1 309799.DICTH_1915 1.24e-37 140.0 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity tldE2 - - - - - - - - - - - PmbA_TldD k59_112154_1 765912.Thimo_3345 3.8e-29 107.0 2E35S@1|root,32Y5P@2|Bacteria,1N6WS@1224|Proteobacteria,1SD5T@1236|Gammaproteobacteria,1X269@135613|Chromatiales 135613|Chromatiales S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_112154_2 1026882.MAMP_03073 6.66e-44 177.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales 72273|Thiotrichales M PFAM AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA k59_14539_1 768710.DesyoDRAFT_1808 1.38e-05 50.1 COG0517@1|root,COG0517@2|Bacteria,1TQ4J@1239|Firmicutes,24B68@186801|Clostridia 186801|Clostridia S Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_27843_1 1049564.TevJSym_ae00330 1.54e-62 215.0 28IG4@1|root,2Z8HN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_27843_2 1049564.TevJSym_ae00330 5.56e-17 84.7 28IG4@1|root,2Z8HN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1660_1 335543.Sfum_1220 1.65e-72 239.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MR17@213462|Syntrophobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_170732_1 929713.NIASO_13490 1.21e-07 58.2 COG0304@1|root,COG0304@2|Bacteria,4NEU6@976|Bacteroidetes 976|Bacteroidetes IQ synthase - - - - - - - - - - - - Ketoacyl-synt_2,ketoacyl-synt k59_112155_1 1049564.TevJSym_ao00070 2.01e-140 409.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1J9E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3318 GDC-P k59_41013_1 1049564.TevJSym_ap00590 5.59e-289 790.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1J5C7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_41013_2 1049564.TevJSym_ap00580 6.1e-96 281.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1J746@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_41013_3 1049564.TevJSym_ap00570 4.9e-11 61.6 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J4GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_21511_1 1125863.JAFN01000001_gene2501 5.75e-18 78.2 COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2WRA3@28221|Deltaproteobacteria 28221|Deltaproteobacteria U PFAM Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_21511_2 338966.Ppro_1695 2.25e-99 297.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,43T81@69541|Desulfuromonadales 28221|Deltaproteobacteria F Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_177023_1 1178482.BJB45_18360 3.25e-85 262.0 COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1XHKB@135619|Oceanospirillales 135619|Oceanospirillales E Glutathionylspermidine synthase - - 3.5.1.78,6.3.1.8 ko:K01460 ko00480,ko01100,map00480,map01100 - R01917,R01918 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CHAP,GSP_synth k59_60286_1 1382356.JQMP01000003_gene1988 7.1e-118 347.0 COG1023@1|root,COG1023@2|Bacteria,2G5YD@200795|Chloroflexi,27XH5@189775|Thermomicrobia 189775|Thermomicrobia C 6-phosphogluconate dehydrogenase, C-terminal domain - - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_86173_1 443143.GM18_2688 2.18e-128 376.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_151139_1 1288494.EBAPG3_1040 1.52e-06 48.1 COG2954@1|root,COG2954@2|Bacteria,1PKQI@1224|Proteobacteria,2WAYU@28216|Betaproteobacteria,374IK@32003|Nitrosomonadales 28216|Betaproteobacteria S CYTH - GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0050355 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_151139_2 472759.Nhal_3055 5.39e-57 196.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales 135613|Chromatiales E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_177024_1 1504672.669784874 2.05e-99 300.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2VP2D@28216|Betaproteobacteria,4AEEG@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_86174_1 96561.Dole_2292 7.83e-71 234.0 COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1QTUE@1224|Proteobacteria,43BRM@68525|delta/epsilon subdivisions,2WM4A@28221|Deltaproteobacteria,2MHXR@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_34385_2 335543.Sfum_1278 1.6e-253 715.0 COG0427@1|root,COG0454@1|root,COG0427@2|Bacteria,COG0456@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MR2F@213462|Syntrophobacterales 28221|Deltaproteobacteria C acetyl-CoA - - - ko:K18122,ko:K18288 ko00650,ko00660,ko01100,ko01200,map00650,map00660,map01100,map01200 - R02407,R05336,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - iAF987.Gmet_2142,iAF987.Gmet_3304 AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3 k59_112163_1 1026882.MAMP_03024 4.5e-74 228.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,45ZPM@72273|Thiotrichales 72273|Thiotrichales E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_189990_1 199310.c3056 1.59e-90 276.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,3XMZ0@561|Escherichia 1236|Gammaproteobacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - iPC815.YPO2896,iYL1228.KPN_02862 Aminotran_5 k59_8408_2 864073.HFRIS_023810 1.18e-43 165.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1N17V@1224|Proteobacteria,2WEJE@28216|Betaproteobacteria,47337@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain cpxA - 2.7.13.3 ko:K02484,ko:K07640,ko:K07642 ko01503,ko02020,map01503,map02020 M00447,M00450,M00645,M00646,M00648,M00727,M00728 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_8408_4 765913.ThidrDRAFT_0878 1.48e-07 54.7 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1WWUY@135613|Chromatiales 135613|Chromatiales L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_8408_5 1265505.ATUG01000002_gene1297 3.8e-59 190.0 COG2267@1|root,COG2267@2|Bacteria,1QUAA@1224|Proteobacteria,42P6J@68525|delta/epsilon subdivisions,2WK3W@28221|Deltaproteobacteria,2MIVT@213118|Desulfobacterales 28221|Deltaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 k59_27862_1 439235.Dalk_2275 8.02e-44 150.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,2MJ8Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Hydrogenase (NiFe) small subunit HydA hydA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 ko:K00534,ko:K05927,ko:K06282,ko:K18008 ko00633,ko01120,map00633,map01120 - R00019,R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_27862_2 1123373.ATXI01000014_gene24 1.11e-29 116.0 COG0374@1|root,COG0374@2|Bacteria,2GH4N@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Nickel-dependent hydrogenase - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_183734_2 523791.Kkor_0311 8.45e-26 114.0 COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,1XJ1A@135619|Oceanospirillales 135619|Oceanospirillales E Thermolysin metallopeptidase, catalytic domain - - 3.4.24.25 ko:K08604 ko05110,ko05111,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002 - - - FTP,PPC,P_proprotein,PepSY,Peptidase_M4,Peptidase_M4_C k59_48692_3 706439.HMPREF9057_01080 1.22e-22 99.0 COG0077@1|root,COG0077@2|Bacteria,2II6N@201174|Actinobacteria 201174|Actinobacteria E Prephenate dehydratase - - 4.1.1.100 ko:K19546 ko01130,map01130 M00787 - - ko00000,ko00001,ko00002,ko01000 - - - PDT k59_48692_4 312309.VF_1078 2.44e-27 105.0 COG4954@1|root,COG4954@2|Bacteria,1RE0C@1224|Proteobacteria,1S3ZC@1236|Gammaproteobacteria,1Y17U@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF2000) - - - - - - - - - - - - DUF2000 k59_48692_6 1345695.CLSA_c20310 6.76e-74 236.0 COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,36GVW@31979|Clostridiaceae 186801|Clostridia EG Transporter Family - - - - - - - - - - - - EamA k59_171956_1 1049564.TevJSym_ad01190 2.59e-107 319.0 COG1639@1|root,COG1639@2|Bacteria,1PGTV@1224|Proteobacteria,1RX2M@1236|Gammaproteobacteria,1JB69@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_165218_1 95619.PM1_0215725 1.82e-68 223.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_68293_1 335543.Sfum_0458 1.82e-80 255.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MR53@213462|Syntrophobacterales 28221|Deltaproteobacteria I PFAM Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_87501_1 83406.HDN1F_35090 1.13e-35 135.0 2DB87@1|root,2Z7QE@2|Bacteria,1MWQ5@1224|Proteobacteria,1RPED@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3438) - - - - - - - - - - - - DUF3438 k59_87501_2 83406.HDN1F_35080 5.52e-38 137.0 2DB81@1|root,2Z7PS@2|Bacteria,1MY5A@1224|Proteobacteria,1RP4B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Integrating conjugative element protein - - - - - - - - - - - - DUF2895 k59_185170_1 1217718.ALOU01000006_gene1651 1.02e-89 298.0 COG0515@1|root,COG0515@2|Bacteria,1MWVZ@1224|Proteobacteria,2WEGS@28216|Betaproteobacteria,1KHS4@119060|Burkholderiaceae 28216|Betaproteobacteria KLT Serine threonine protein kinase - - - - - - - - - - - - DUF4384,Pkinase k59_185170_2 349521.HCH_04245 2.36e-37 142.0 COG1073@1|root,COG1073@2|Bacteria,1R8S6@1224|Proteobacteria,1S4WS@1236|Gammaproteobacteria,1XPZG@135619|Oceanospirillales 135619|Oceanospirillales S alpha beta - - - - - - - - - - - - - k59_185170_3 349521.HCH_04244 1.94e-155 471.0 COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,1MWPA@1224|Proteobacteria,1RRKA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M FOG TPR repeat SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Peptidase_C14,Sel1 k59_185170_4 765913.ThidrDRAFT_2276 9.31e-84 292.0 COG4625@1|root,COG4625@2|Bacteria,1RDX6@1224|Proteobacteria,1S53I@1236|Gammaproteobacteria,1WYNW@135613|Chromatiales 135613|Chromatiales S TIGRFAM outer membrane autotransporter barrel - - - - - - - - - - - - Autotransporter k59_185170_5 269798.CHU_0902 4.34e-20 103.0 COG2931@1|root,COG2931@2|Bacteria,4P7R1@976|Bacteroidetes,47X32@768503|Cytophagia 976|Bacteroidetes Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - k59_185170_6 1487953.JMKF01000027_gene1467 4.15e-130 407.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1G0YR@1117|Cyanobacteria,1H73E@1150|Oscillatoriales 1117|Cyanobacteria O Domain of unknown function (DUF4915) - - - - - - - - - - - - DUF4915,Glyco_transf_41,TPR_1,TPR_2,TPR_8 k59_146081_2 1198232.CYCME_1100 1.47e-37 136.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZQ6@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_171960_1 439235.Dalk_1820 6.62e-65 216.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2MISZ@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Cytochrome c, bacterial - - - - - - - - - - - - Cytochrom_CIII,Cytochrome_C554,Cytochrome_cB k59_81335_1 1123519.PSJM300_03890 4.02e-59 194.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1YZZW@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_165222_1 1047013.AQSP01000125_gene2640 3.87e-54 182.0 COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria 2|Bacteria G Major Facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1,Sugar_tr k59_2873_1 1120980.JQKH01000068_gene551 1.19e-47 168.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2VM59@28216|Betaproteobacteria,2KSHJ@206351|Neisseriales 206351|Neisseriales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6C k59_127142_1 933262.AXAM01000051_gene2978 7.28e-174 499.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MHQ6@213118|Desulfobacterales 28221|Deltaproteobacteria E D-isomer specific 2-hydroxyacid dehydrogenase catalytic - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_146084_1 439235.Dalk_2438 2.54e-20 91.3 COG0664@1|root,COG0664@2|Bacteria,1RCF4@1224|Proteobacteria,43BRQ@68525|delta/epsilon subdivisions,2X72K@28221|Deltaproteobacteria,2MJHW@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - DUF4388,cNMP_binding k59_146084_2 933262.AXAM01000016_gene168 6.95e-40 137.0 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2MI9K@213118|Desulfobacterales 28221|Deltaproteobacteria S Gtr1/RagA G protein conserved region mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf k59_54868_2 765911.Thivi_2459 3.28e-102 306.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,1S0NK@1236|Gammaproteobacteria,1WWZZ@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C - - - - - - - - - - - - Cytochrom_C k59_35941_1 477184.KYC_12283 9.36e-168 490.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,3T4S5@506|Alcaligenaceae 28216|Betaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_158929_1 1121405.dsmv_2298 7.27e-91 291.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CoA-binding domain protein acs - 6.2.1.13 ko:K01905,ko:K09181,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_100188_1 1123487.KB892834_gene2990 1.54e-58 211.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVEE@206389|Rhodocyclales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg k59_113471_1 765914.ThisiDRAFT_0180 6.85e-24 100.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_197391_1 1049564.TevJSym_bu00050 9.3e-156 474.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_171972_1 713586.KB900536_gene2881 3.68e-20 84.3 2EJPI@1|root,33DEC@2|Bacteria,1NM06@1224|Proteobacteria,1SHXW@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_171972_2 572477.Alvin_2173 1.47e-12 67.4 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales 135613|Chromatiales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_81346_1 1496688.ER33_14805 6.31e-90 280.0 COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,22TKK@167375|Cyanobium 1117|Cyanobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_152357_1 546274.EIKCOROL_00912 4.13e-50 179.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria,2KPS6@206351|Neisseriales 206351|Neisseriales S Phospholipase, patatin family - - - ko:K07001 - - - - ko00000 - - - Patatin k59_204192_1 118173.KB235910_gene4740 1.55e-67 211.0 COG1905@1|root,COG1905@2|Bacteria,1G54V@1117|Cyanobacteria,1HAJC@1150|Oscillatoriales 1117|Cyanobacteria C PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit hoxE - 1.6.5.3 ko:K05586 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx k59_204192_2 926550.CLDAP_28490 5.35e-56 191.0 COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi 200795|Chloroflexi C PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit hoxF - 1.6.5.3 ko:K00335,ko:K05587 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_9917_4 159087.Daro_1233 8.87e-173 492.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,2KV2R@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC1 - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_9917_5 1165841.SULAR_02168 2.33e-22 98.6 COG0500@1|root,COG2226@2|Bacteria,1RF5Y@1224|Proteobacteria,42U9R@68525|delta/epsilon subdivisions,2YRQQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q methyltransferase - - - - - - - - - - - - - k59_9917_6 1192034.CAP_3385 1.35e-151 453.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria 28221|Deltaproteobacteria H TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_107056_1 1123514.KB905899_gene2011 7.23e-32 116.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,460J4@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_74447_1 69328.PVLB_04425 9.2e-46 152.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S stringent starvation protein b sspB GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_74447_2 443218.AS9A_4559 8.16e-05 53.5 COG4221@1|root,COG4221@2|Bacteria,2GKK7@201174|Actinobacteria,233VT@1762|Mycobacteriaceae 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_74447_4 287.DR97_5631 2.89e-28 120.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RNQR@1236|Gammaproteobacteria,1YDE1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Putative methyltransferase ynbC GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704 - - - - - - - - - - Hydrolase_4,Methyltransf_20 k59_74447_5 927677.ALVU02000001_gene4017 8.32e-25 108.0 COG4589@1|root,COG4589@2|Bacteria,1GCQF@1117|Cyanobacteria 1117|Cyanobacteria S Belongs to the CDS family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_100504_1 313606.M23134_04935 5.25e-46 172.0 COG1538@1|root,COG1538@2|Bacteria,4NHGK@976|Bacteroidetes 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - ABC_sub_bind,OEP k59_68572_2 1049564.TevJSym_be00360 1.63e-120 360.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1J5VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction histidine kinase phoQ - 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c,PhoQ_Sensor k59_185494_1 96561.Dole_2273 1.22e-103 313.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MJ5M@213118|Desulfobacterales 28221|Deltaproteobacteria E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_165447_1 384676.PSEEN1134 2.9e-22 94.0 2C969@1|root,33MT5@2|Bacteria,1P4E5@1224|Proteobacteria,1SU8T@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_43272_1 335543.Sfum_2497 2.38e-71 229.0 COG4591@1|root,COG4591@2|Bacteria,1RD9H@1224|Proteobacteria,43AMQ@68525|delta/epsilon subdivisions,2X61T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_107356_1 1122201.AUAZ01000023_gene2989 1.51e-168 520.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,1RY2M@1236|Gammaproteobacteria,46772@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3 k59_107356_2 1122201.AUAZ01000023_gene2988 4.27e-130 374.0 28Q1W@1|root,2ZCK4@2|Bacteria,1RDIF@1224|Proteobacteria,1S4Y2@1236|Gammaproteobacteria,467SB@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_107356_3 1122201.AUAZ01000023_gene2987 1.85e-131 380.0 COG3703@1|root,COG3703@2|Bacteria,1PJ04@1224|Proteobacteria,1S2RZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P AIG2-like family - - - - - - - - - - - - AIG2_2 k59_139375_1 1524467.IV04_14525 1.18e-25 106.0 COG1974@1|root,COG1974@2|Bacteria,1RHIM@1224|Proteobacteria,1TB37@1236|Gammaproteobacteria,4058B@613|Serratia 1236|Gammaproteobacteria K Peptidase S24-like - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_29446_1 395493.BegalDRAFT_3308 3.16e-104 325.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,4601E@72273|Thiotrichales 72273|Thiotrichales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.117,4.2.1.3 ko:K01681,ko:K20455 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900,R11263 RC00497,RC00498,RC00618,RC01152 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_29446_2 2340.JV46_20120 2.15e-227 632.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,1J5BN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria prpF GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0071704,GO:0072329,GO:1901575 - ko:K09788 ko00640,map00640 - R11264 RC03405 ko00000,ko00001,ko01000 - - - PrpF k59_62181_1 368407.Memar_0463 4.12e-36 135.0 COG1180@1|root,arCOG00946@2157|Archaea 2157|Archaea C PFAM Radical SAM domain protein - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_3095_1 1049564.TevJSym_bh00300 1.04e-33 128.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1J4ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_10197_1 1049564.TevJSym_al00450 2.77e-07 47.8 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,1SCFF@1236|Gammaproteobacteria,1J7C9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0434 family ycaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09791 - - - - ko00000 - - - Trm112p k59_10197_3 1249627.D779_3854 1.51e-43 147.0 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1WYEK@135613|Chromatiales 135613|Chromatiales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_127488_1 991905.SL003B_1031 5.64e-134 397.0 COG0845@1|root,COG0845@2|Bacteria,1Q112@1224|Proteobacteria,2V906@28211|Alphaproteobacteria,4BSRF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_139376_1 794846.AJQU01000071_gene2084 2.2e-72 238.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 k59_23187_1 118163.Ple7327_3996 4.96e-120 353.0 COG2334@1|root,COG2334@2|Bacteria,1G1QD@1117|Cyanobacteria,3VHR8@52604|Pleurocapsales 1117|Cyanobacteria S PFAM Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_159225_1 1408254.T458_06295 3.34e-40 163.0 COG1404@1|root,COG1404@2|Bacteria,1UGHG@1239|Firmicutes,4HC8T@91061|Bacilli,26TIJ@186822|Paenibacillaceae 91061|Bacilli O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8,SLH k59_12986_2 1049564.TevJSym_aj00260 2.51e-08 56.6 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1J6NT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_168532_1 1049564.TevJSym_aj00730 1.03e-88 282.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1J4N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_9,Response_reg k59_168532_2 631362.Thi970DRAFT_03095 1.23e-26 106.0 28T0P@1|root,2ZF9Z@2|Bacteria,1RAUV@1224|Proteobacteria,1S23D@1236|Gammaproteobacteria,1WY26@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_168532_3 1049564.TevJSym_aa01980 8.12e-94 278.0 COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,1RPW4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_168532_4 768671.ThimaDRAFT_3277 6.54e-98 290.0 COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RMZN@1236|Gammaproteobacteria,1WWIN@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_168532_6 1049564.TevJSym_aa01930 4.8e-44 166.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_168535_2 1121456.ATVA01000003_gene3032 3.83e-10 58.5 2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42WSF@68525|delta/epsilon subdivisions,2WRK4@28221|Deltaproteobacteria,2ME1R@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_25_1 1379281.AVAG01000054_gene553 7.42e-08 52.8 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2M8XC@213115|Desulfovibrionales 28221|Deltaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_25_2 933262.AXAM01000048_gene2587 4.99e-48 162.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2WMWK@28221|Deltaproteobacteria,2MIZD@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_58360_1 96561.Dole_0001 1.7e-48 171.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,2MHNX@213118|Desulfobacterales 28221|Deltaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_19475_2 1254432.SCE1572_41685 2.42e-22 96.7 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,2YTT5@29|Myxococcales 28221|Deltaproteobacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_110225_1 105559.Nwat_1969 5.75e-70 243.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYUH@1236|Gammaproteobacteria,1X2A1@135613|Chromatiales 135613|Chromatiales T SMART Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_110225_2 105559.Nwat_1970 3.83e-73 229.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1WYN6@135613|Chromatiales 135613|Chromatiales K SMART cyclic nucleotide-binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_116700_1 386456.JQKN01000002_gene2817 5.53e-24 107.0 COG2208@1|root,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota,23PHZ@183925|Methanobacteria 183925|Methanobacteria T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - 5TM-5TMR_LYT,SpoIIE k59_142615_2 926560.KE387023_gene1882 2.4e-26 105.0 COG5640@1|root,COG5640@2|Bacteria,1WN2M@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Trypsin-like serine protease - - - - - - - - - - - - Trypsin k59_142618_1 1298593.TOL_1163 2.86e-245 686.0 COG2159@1|root,COG2159@2|Bacteria,1R8PV@1224|Proteobacteria,1S8J0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AIPR protein - - - - - - - - - - - - AIPR k59_142619_1 880072.Desac_0432 4.44e-80 249.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - SpoIIAA-like,Usp k59_116705_1 1458275.AZ34_10705 1.3e-35 129.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,2VJPP@28216|Betaproteobacteria,4AAIJ@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM UBA THIF-type NAD FAD binding protein moeB - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k59_116705_2 1123487.KB892866_gene1602 5.09e-176 546.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KUCK@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - CBS,CZB,EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_12990_2 1366050.N234_24790 1.58e-40 154.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VJ2Q@28216|Betaproteobacteria,1KC1W@119060|Burkholderiaceae 28216|Betaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_181523_1 879212.DespoDRAFT_02361 1.6e-07 56.2 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria,2MJ93@213118|Desulfobacterales 28221|Deltaproteobacteria N PFAM MotA TolQ ExbB proton channel - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_175016_1 1232410.KI421424_gene1696 1.81e-183 538.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,43TR4@69541|Desulfuromonadales 28221|Deltaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_162098_4 876044.IMCC3088_810 1.27e-36 149.0 COG4733@1|root,COG4733@2|Bacteria,1R55I@1224|Proteobacteria,1S5X2@1236|Gammaproteobacteria 1236|Gammaproteobacteria D cellulase activity - - - - - - - - - - - - - k59_162098_5 1298593.TOL_2660 2.36e-58 184.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S8W1@1236|Gammaproteobacteria,1XKRT@135619|Oceanospirillales 135619|Oceanospirillales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_149156_1 1304872.JAGC01000003_gene3744 1.2e-06 49.3 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2M8ZH@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM sulfate adenylyltransferase sat - 2.7.1.25,2.7.7.4 ko:K00958,ko:K13811 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_32475_2 1049564.TevJSym_ag00520 1.84e-97 290.0 COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,1S3KS@1236|Gammaproteobacteria,1JBXT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Cobalt uptake substrate-specific transmembrane region - - - - - - - - - - - - CbiM k59_32475_3 1049564.TevJSym_ag00550 3.11e-46 150.0 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SD3Y@1236|Gammaproteobacteria,1J6YA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_13013_1 349521.HCH_02680 4.73e-101 303.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,1XH2C@135619|Oceanospirillales 135619|Oceanospirillales M mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_13013_2 1265503.KB905165_gene1066 3.43e-68 214.0 2ABP6@1|root,31153@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_13013_3 1249627.D779_3959 2.77e-18 84.7 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_116746_1 1499967.BAYZ01000048_gene2700 3.97e-135 397.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2,MFS_3 k59_77862_2 1297570.MESS4_430180 0.000318 43.5 COG3609@1|root,COG3609@2|Bacteria,1NA19@1224|Proteobacteria,2U96N@28211|Alphaproteobacteria,43QT7@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Evidence 4 Homologs of previously reported genes of - - - ko:K07746 - - - - ko00000,ko02048 - - - ParD_antitoxin k59_77862_3 472759.Nhal_3643 1.55e-22 90.5 COG3668@1|root,COG3668@2|Bacteria,1N2I9@1224|Proteobacteria,1SBPZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S plasmid stabilization - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_136170_2 1042375.AFPL01000019_gene205 0.000289 43.1 COG0369@1|root,COG3182@1|root,COG0369@2|Bacteria,COG3182@2|Bacteria,1MWYV@1224|Proteobacteria,1RY05@1236|Gammaproteobacteria,465H6@72275|Alteromonadaceae 1236|Gammaproteobacteria P Flavodoxin cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,FAD_binding_6,Flavodoxin_1,NAD_binding_1,PepSY_TM k59_97286_3 203122.Sde_3266 3.63e-108 328.0 2E0EH@1|root,32W10@2|Bacteria,1NV08@1224|Proteobacteria,1SNIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_162099_1 1239962.C943_01122 1.01e-42 146.0 COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,47KE8@768503|Cytophagia 976|Bacteroidetes F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_162099_2 765911.Thivi_0961 9.63e-65 203.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1WY75@135613|Chromatiales 135613|Chromatiales H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis - - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_162099_3 686340.Metal_1060 8.39e-74 230.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales 135618|Methylococcales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_162099_4 472759.Nhal_1895 7.8e-168 481.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1X04S@135613|Chromatiales 135613|Chromatiales H S-adenosyl-L-homocysteine hydrolase, NAD binding domain - - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_149165_1 1265505.ATUG01000003_gene578 9.25e-97 289.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,rve k59_200987_1 1049564.TevJSym_ar00540 1.11e-69 227.0 COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,1J4RT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_200987_2 1049564.TevJSym_ar00550 4.43e-115 335.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RQAV@1236|Gammaproteobacteria,1J5S6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain walR - - - - - - - - - - - Response_reg,Trans_reg_C k59_200987_3 1049564.TevJSym_bk00230 4.7e-12 65.5 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_26018_1 1439940.BAY1663_04438 2.24e-105 318.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_116757_1 136993.KB900626_gene3082 2.85e-62 223.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,36YC7@31993|Methylocystaceae 28211|Alphaproteobacteria S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_19528_1 1049564.TevJSym_bd00350 7.07e-150 447.0 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1J6GE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - GAF,HDOD,Pkinase k59_19528_2 765910.MARPU_11455 0.000181 48.1 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,1S4H2@1236|Gammaproteobacteria,1WXZI@135613|Chromatiales 135613|Chromatiales C Hydrogenase expression formation protein - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_13026_2 2340.JV46_28910 1.99e-43 144.0 COG0607@1|root,COG0607@2|Bacteria,1QMXA@1224|Proteobacteria,1S6DI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_13026_3 1049564.TevJSym_ax00350 2.17e-43 141.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,1J6VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_162104_1 118173.KB235910_gene4621 4.84e-83 261.0 COG0297@1|root,COG0297@2|Bacteria,1G1YU@1117|Cyanobacteria,1H8IV@1150|Oscillatoriales 1117|Cyanobacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA2 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_162104_2 1249627.D779_2664 3.83e-59 197.0 COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_64881_2 1255043.TVNIR_1576 2.98e-243 675.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales 135613|Chromatiales C TIGRFAM isocitrate dehydrogenase, NADP-dependent - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh k59_64881_3 765911.Thivi_1117 2.67e-62 201.0 COG0642@1|root,COG0642@2|Bacteria,1QVPJ@1224|Proteobacteria,1T2G0@1236|Gammaproteobacteria,1WWWD@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c k59_64881_4 1249627.D779_4204 4.48e-136 413.0 COG0457@1|root,COG0784@1|root,COG0457@2|Bacteria,COG0784@2|Bacteria,1NNCT@1224|Proteobacteria,1RY9B@1236|Gammaproteobacteria,1WXKE@135613|Chromatiales 135613|Chromatiales T PFAM response regulator receiver - - - - - - - - - - - - Response_reg,TPR_16,TPR_19,TPR_8 k59_90833_1 748658.KB907321_gene813 8.25e-47 156.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1WZIV@135613|Chromatiales 135613|Chromatiales S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_90833_2 1049564.TevJSym_ab01230 4.28e-147 420.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_26020_1 666681.M301_1477 1.4e-145 422.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,2KKYZ@206350|Nitrosomonadales 206350|Nitrosomonadales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_136180_1 555779.Dthio_PD1204 1.32e-153 442.0 COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MABV@213115|Desulfovibrionales 28221|Deltaproteobacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_188027_1 439235.Dalk_2649 4.26e-58 191.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS-1 - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_103767_1 1049564.TevJSym_ba00030 0.0 1353.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_103767_2 1168065.DOK_16318 1.74e-217 608.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1J4Q7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016741,GO:0016742,GO:0016772,GO:0016774,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_1135 ATP-grasp,Epimerase k59_123231_1 1049564.TevJSym_ab01960 9.24e-100 306.0 COG1155@1|root,COG1155@2|Bacteria,1R22G@1224|Proteobacteria 1224|Proteobacteria C ATPsynthase alpha/beta subunit N-term extension - - - - - - - - - - - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_116763_1 1049564.TevJSym_bd00350 5.56e-81 263.0 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1J6GE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - GAF,HDOD,Pkinase k59_51956_1 589865.DaAHT2_1753 4.66e-117 356.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MN6X@213118|Desulfobacterales 28221|Deltaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_97289_1 1033806.HTIA_1017 9.96e-15 79.7 arCOG04041@1|root,arCOG04518@1|root,arCOG04518@2157|Archaea,arCOG07592@2157|Archaea,2Y8F4@28890|Euryarchaeota,241A5@183963|Halobacteria 183963|Halobacteria S transcriptional regulators - - - - - - - - - - - - - k59_201000_2 1040983.AXAE01000001_gene2987 6.89e-30 122.0 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,2U4TG@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ketoacyl-synt k59_142658_1 1049564.TevJSym_bh00130 1.24e-121 355.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_77881_1 1123401.JHYQ01000037_gene1654 6.16e-11 62.0 COG0412@1|root,COG0412@2|Bacteria,1RCWF@1224|Proteobacteria,1RY38@1236|Gammaproteobacteria,462RE@72273|Thiotrichales 72273|Thiotrichales Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_77881_2 685035.ADAE01000012_gene129 1.32e-25 102.0 COG3791@1|root,COG3791@2|Bacteria,1NC41@1224|Proteobacteria,2UGK2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - - k59_77881_3 743299.Acife_0205 3.2e-50 164.0 COG0454@1|root,COG0456@2|Bacteria,1N506@1224|Proteobacteria,1S97J@1236|Gammaproteobacteria,2NDC1@225057|Acidithiobacillales 225057|Acidithiobacillales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_77881_4 864073.HFRIS_022488 4.69e-13 70.9 COG0697@1|root,COG0697@2|Bacteria,1MVHN@1224|Proteobacteria,2VI21@28216|Betaproteobacteria,4736N@75682|Oxalobacteraceae 28216|Betaproteobacteria EG of the drug metabolite transporter (DMT) - - - - - - - - - - - - EamA k59_175039_1 748247.AZKH_2578 1.87e-128 396.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KUC8@206389|Rhodocyclales 206389|Rhodocyclales V Protein export membrane protein - - - ko:K18902 - M00698 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_175039_2 1280666.ATVS01000004_gene2506 2.01e-25 111.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,4BW3Y@830|Butyrivibrio 186801|Clostridia S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,DLH,FSH1,Hydrolase_4 k59_175039_4 454957.IA64_10990 2.37e-69 226.0 COG4748@1|root,COG4748@2|Bacteria,1MXDA@1224|Proteobacteria,1RSNI@1236|Gammaproteobacteria,1X9Y0@135614|Xanthomonadales 135614|Xanthomonadales S Type I restriction enzyme R protein N terminus (HSDR_N) - - - ko:K07504 - - - - ko00000 - - - HSDR_N k59_51958_1 2340.JV46_15720 2.56e-62 199.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1J54C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_87_1 1120970.AUBZ01000006_gene1209 7.3e-95 306.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,465DD@72275|Alteromonadaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_175041_1 1121405.dsmv_1436 6.99e-108 327.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_51967_1 338963.Pcar_1383 1.29e-56 194.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_6550_2 1300345.LF41_1785 3.23e-20 91.7 COG1266@1|root,COG1266@2|Bacteria,1R5RA@1224|Proteobacteria,1S0ZC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi k59_201021_1 768671.ThimaDRAFT_3755 2.51e-133 390.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_77906_1 269797.Mbar_A2771 1.59e-102 306.0 COG2133@1|root,arCOG02796@2157|Archaea,2Y6WR@28890|Euryarchaeota,2NACH@224756|Methanomicrobia 224756|Methanomicrobia G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_129794_1 1122201.AUAZ01000004_gene3448 1.88e-117 347.0 2DB8P@1|root,2Z7SB@2|Bacteria,1R765@1224|Proteobacteria,1SIAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_129794_2 1121935.AQXX01000096_gene2564 3.05e-44 146.0 COG1396@1|root,COG1396@2|Bacteria,1N6TH@1224|Proteobacteria,1SFCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_19,HTH_3,HTH_31 k59_129794_3 1122201.AUAZ01000004_gene3450 3.65e-104 311.0 COG2856@1|root,COG2856@2|Bacteria,1RAAQ@1224|Proteobacteria,1S4ZZ@1236|Gammaproteobacteria,468YC@72275|Alteromonadaceae 1236|Gammaproteobacteria E IrrE N-terminal-like domain - - - - - - - - - - - - Peptidase_M78 k59_149202_1 2340.JV46_15380 8.7e-52 174.0 28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - dsrS - - - - - - - - - - - - k59_149202_2 1049564.TevJSym_aw00070 3.92e-37 127.0 COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the HesB IscA family dsrR - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_194525_2 706587.Desti_1466 1.12e-86 263.0 COG1456@1|root,COG1456@2|Bacteria,1R9BV@1224|Proteobacteria,42P65@68525|delta/epsilon subdivisions,2WMGX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Fe-S cluster domain protein - - - - - - - - - - - - DUF3786,FeS k59_45510_1 1049564.TevJSym_ah00470 2.31e-09 57.0 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1318) - - - - - - - - - - - - DUF1318 k59_45510_2 1049564.TevJSym_ah00460 3.21e-173 516.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_45510_3 477228.YO5_05254 1.29e-57 180.0 COG2824@1|root,COG2824@2|Bacteria,1RGUU@1224|Proteobacteria,1S60W@1236|Gammaproteobacteria,1Z2YS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P Zn-ribbon-containing protein involved in phosphonate metabolism phnA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_147_1 880072.Desac_1091 1.55e-10 60.8 COG0310@1|root,COG0310@2|Bacteria,1RJRC@1224|Proteobacteria,42QZ5@68525|delta/epsilon subdivisions,2WMQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM cobalamin (vitamin B12) biosynthesis CbiM - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_147_2 439235.Dalk_2004 5.42e-22 93.2 COG2373@1|root,COG2373@2|Bacteria,1MYWP@1224|Proteobacteria,42SBT@68525|delta/epsilon subdivisions,2WPA3@28221|Deltaproteobacteria,2MK9A@213118|Desulfobacterales 28221|Deltaproteobacteria S Large extracellular alpha-helical protein - - - ko:K16915 ko02010,map02010 M00246 - - ko00000,ko00001,ko00002,ko02000 - - - - k59_6608_1 879212.DespoDRAFT_02599 4.39e-67 215.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2MIXK@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7_1,DZR,SHOCT,zinc_ribbon_2 k59_162199_1 1122201.AUAZ01000006_gene3903 4.42e-24 99.4 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RR72@1236|Gammaproteobacteria,46AB2@72275|Alteromonadaceae 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein, family 7 dctP GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015849,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702 - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_116837_1 565033.GACE_1724 2.2e-07 54.7 arCOG05636@1|root,arCOG05636@2157|Archaea,2Y231@28890|Euryarchaeota,246ID@183980|Archaeoglobi 183980|Archaeoglobi C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_162200_1 1125863.JAFN01000001_gene2311 1.51e-15 78.6 COG0215@1|root,COG0215@2|Bacteria 2|Bacteria J cysteine-tRNA ligase activity - - - - - - - - - - - - Peptidase_S51 k59_71446_2 323850.Shew_0995 1.94e-178 501.0 COG0582@1|root,COG0582@2|Bacteria,1QB64@1224|Proteobacteria,1RY8S@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_1,Phage_int_SAM_4,Phage_integrase k59_123320_1 1101190.ARWB01000001_gene1255 7.56e-79 244.0 COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,371CA@31993|Methylocystaceae 28211|Alphaproteobacteria J Formyl transferase, C-terminal domain - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_26087_1 1121451.DESAM_22068 2.24e-06 49.3 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2M8N0@213115|Desulfovibrionales 28221|Deltaproteobacteria ET PFAM Extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_142706_1 316274.Haur_2046 2.75e-32 126.0 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_181651_2 1056512.D515_04312 4.37e-58 184.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S5JT@1236|Gammaproteobacteria,1Y2RP@135623|Vibrionales 135623|Vibrionales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_168669_1 225937.HP15_2025 1.82e-44 150.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,465CK@72275|Alteromonadaceae 1236|Gammaproteobacteria F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 SAICAR_synt k59_97366_1 396588.Tgr7_1229 6.8e-37 142.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales 135613|Chromatiales T PFAM EAL domain - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_45523_1 237368.SCABRO_03764 6.49e-85 278.0 COG1033@1|root,COG1033@2|Bacteria,2IYET@203682|Planctomycetes 203682|Planctomycetes S of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_181657_1 626887.J057_07716 1.87e-62 206.0 COG0388@1|root,COG1247@1|root,COG0388@2|Bacteria,COG1247@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,4648Q@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_13086_1 545264.KB898751_gene2623 2.52e-129 372.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_64938_2 477228.YO5_06957 7.06e-10 67.8 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1SX1M@1236|Gammaproteobacteria,1Z3JE@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_64938_3 1049564.TevJSym_am00380 5.79e-46 160.0 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria,1J75C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Type IV pilus assembly protein PilX C-term pilX - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_116848_1 1049564.TevJSym_aj00240 1.27e-71 228.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1J5BU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_110328_1 406817.XNC1_2591 0.00013 43.1 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria 1236|Gammaproteobacteria K response regulator uvrY GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_110328_2 1049564.TevJSym_bm00100 5.37e-60 189.0 COG3151@1|root,COG3151@2|Bacteria,1MYG8@1224|Proteobacteria,1S7P6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09920 - - - - ko00000 - - - DUF1249 k59_110328_3 1049564.TevJSym_bm00090 4.06e-31 112.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_162207_1 1206726.BAFV01000063_gene4485 8.51e-40 149.0 COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4FWJS@85025|Nocardiaceae 201174|Actinobacteria C Elongator protein 3, MiaB family, Radical SAM pqqE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_97372_1 335543.Sfum_0927 3.02e-68 213.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42PAH@68525|delta/epsilon subdivisions,2WKSM@28221|Deltaproteobacteria,2MS4X@213462|Syntrophobacterales 28221|Deltaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356,ko:K03503 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_90919_1 1049564.TevJSym_ai00340 1.5e-55 192.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_136272_1 713586.KB900536_gene3002 4.25e-124 374.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales 135613|Chromatiales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_39020_1 926692.AZYG01000007_gene1363 1.13e-31 124.0 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WAJB@53433|Halanaerobiales 186801|Clostridia S phosphoesterase RecJ domain protein nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_194536_2 1049564.TevJSym_ai00810 5.84e-149 427.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1J54U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - iZ_1308.Z5639 UbiA k59_194536_3 1049564.TevJSym_ai00820 1.22e-11 63.2 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_175126_2 251229.Chro_3895 6.1e-06 52.4 COG0827@1|root,COG0827@2|Bacteria,1G7IJ@1117|Cyanobacteria,3VNEX@52604|Pleurocapsales 1117|Cyanobacteria L DNA restriction-modification system - - - - - - - - - - - - MTS k59_110343_1 543632.JOJL01000017_gene9925 2.33e-22 94.0 COG1309@1|root,COG1309@2|Bacteria,2IFAN@201174|Actinobacteria,4DF7G@85008|Micromonosporales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_181665_1 1264700.L0MYI2_9CAUD 1.28e-103 318.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_6630_1 323261.Noc_1997 1e-69 226.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXWZ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_142724_1 56780.SYN_02374 2.02e-72 241.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MQ60@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM leucyl-tRNA synthetase leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_52037_1 519989.ECTPHS_02399 9.78e-128 374.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_155711_1 207559.Dde_2090 2.31e-101 320.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2M7TC@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_188119_1 626887.J057_17880 4.56e-29 120.0 COG2199@1|root,COG2200@1|root,COG2204@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2204@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,4663N@72275|Alteromonadaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_66300_1 400668.Mmwyl1_3924 1.42e-58 192.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,1RPX5@1236|Gammaproteobacteria,1XITY@135619|Oceanospirillales 135619|Oceanospirillales C Aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_21107_1 631362.Thi970DRAFT_04119 9.29e-13 72.4 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_195708_1 399739.Pmen_0471 1.3e-05 48.9 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1YF0S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_59980_1 1123400.KB904802_gene3165 2.15e-125 368.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,45ZPQ@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_53374_1 1049564.TevJSym_ad00860 4.55e-13 67.4 COG1432@1|root,COG1432@2|Bacteria 2|Bacteria S NYN domain - - - - - - - - - - - - CSD,NYN k59_118462_1 1227457.C451_16123 1.86e-07 55.5 COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,23SY7@183963|Halobacteria 183963|Halobacteria G Hydroxypyruvate reductase - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_118462_2 1121405.dsmv_3149 6.83e-64 201.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,42SD7@68525|delta/epsilon subdivisions,2WPI5@28221|Deltaproteobacteria,2MIP3@213118|Desulfobacterales 28221|Deltaproteobacteria K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_79708_1 511051.CSE_08740 1.64e-31 116.0 COG0693@1|root,COG0693@2|Bacteria 2|Bacteria S protein deglycation pfpI - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_79708_2 1463820.JOGW01000010_gene1005 9.66e-12 66.6 COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria 201174|Actinobacteria G Belongs to the pyruvate kinase family pyk GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_124913_1 1121405.dsmv_2161 1.92e-146 429.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_131433_1 105559.Nwat_0720 3.36e-45 152.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1WXW6@135613|Chromatiales 135613|Chromatiales L PFAM NUDIX hydrolase nudE - - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_131433_2 1049564.TevJSym_ao00520 1.08e-132 382.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1J5ZG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313 Inositol_P k59_111840_1 1265505.ATUG01000002_gene1615 1.96e-166 488.0 COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 k59_85830_1 519989.ECTPHS_08558 5.37e-98 314.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_59982_1 1231391.AMZF01000006_gene2718 1.04e-14 75.9 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,2VI96@28216|Betaproteobacteria,3T2Y2@506|Alcaligenaceae 28216|Betaproteobacteria P Rieske [2Fe-2S] domain - - 1.14.12.7 ko:K18068 ko00624,ko01100,ko01120,ko01220,map00624,map01100,map01120,map01220 M00623 R03630 RC00951 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske k59_59982_2 113395.AXAI01000007_gene1331 7.28e-11 64.7 COG1802@1|root,COG1802@2|Bacteria,1Q85H@1224|Proteobacteria,2TUCE@28211|Alphaproteobacteria,3JR96@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K GntR family - - - - - - - - - - - - FCD,GntR k59_46958_1 1158165.KB898879_gene2703 1.24e-15 76.3 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,1RQ2B@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_105216_3 1206731.BAGB01000012_gene2723 1.74e-78 253.0 COG2303@1|root,COG2303@2|Bacteria,2GK9F@201174|Actinobacteria,4FV7Z@85025|Nocardiaceae 201174|Actinobacteria E Cholesterol oxidase - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_163669_1 595460.RRSWK_05984 2.71e-222 625.0 COG3344@1|root,COG3344@2|Bacteria,2J0GH@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_124915_1 457429.ABJI02000040_gene3857 3.37e-66 212.0 COG0426@1|root,COG0426@2|Bacteria,2GJT6@201174|Actinobacteria 201174|Actinobacteria C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Flavodoxin_1,Lactamase_B k59_144422_1 933262.AXAM01000034_gene1567 1.01e-16 77.8 COG1082@1|root,COG1082@2|Bacteria,1RB9A@1224|Proteobacteria,42QVE@68525|delta/epsilon subdivisions,2WMSP@28221|Deltaproteobacteria,2MJQN@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Xylose - - - - - - - - - - - - AP_endonuc_2 k59_144422_2 1121405.dsmv_1708 1.95e-29 112.0 COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,42TXY@68525|delta/epsilon subdivisions,2WQ4J@28221|Deltaproteobacteria,2MJUS@213118|Desulfobacterales 28221|Deltaproteobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_183291_2 247490.KSU1_B0604 3.8e-36 133.0 2EABA@1|root,334FH@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - TIG k59_92444_2 1123274.KB899408_gene3761 2.1e-18 81.6 COG1695@1|root,COG1695@2|Bacteria,2J842@203691|Spirochaetes 203691|Spirochaetes K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_92444_3 1121937.AUHJ01000024_gene67 2.42e-122 361.0 COG3177@1|root,COG3177@2|Bacteria,1MX0V@1224|Proteobacteria,1RQYT@1236|Gammaproteobacteria,465WD@72275|Alteromonadaceae 1236|Gammaproteobacteria S Filamentation induced by cAMP protein fic - - - - - - - - - - - - Fic k59_40641_1 519989.ECTPHS_12545 3.22e-124 382.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_40641_2 279714.FuraDRAFT_1389 1.07e-31 122.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,2KPBZ@206351|Neisseriales 206351|Neisseriales BQ histone deacetylase hda - - - - - - - - - - - Hist_deacetyl k59_53381_2 589924.Ferp_2487 1.62e-45 158.0 COG0123@1|root,arCOG00324@2157|Archaea,2Y2ST@28890|Euryarchaeota,246Y4@183980|Archaeoglobi 183980|Archaeoglobi BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_202650_1 56780.SYN_02714 9.85e-20 89.4 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MQRW@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_34074_1 933262.AXAM01000029_gene2745 1.01e-56 185.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MHVT@213118|Desulfobacterales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_34074_2 525146.Ddes_1240 2.16e-42 147.0 COG4659@1|root,COG4659@2|Bacteria,1PPK1@1224|Proteobacteria,42TAI@68525|delta/epsilon subdivisions,2WNZU@28221|Deltaproteobacteria,2M9S6@213115|Desulfovibrionales 28221|Deltaproteobacteria C Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_189701_2 319224.Sputcn32_0178 2.88e-56 181.0 COG0582@1|root,COG0582@2|Bacteria,1QRWN@1224|Proteobacteria,1SVK3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_79709_1 335541.Swol_1257 7.95e-08 55.1 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,42JKW@68298|Syntrophomonadaceae 186801|Clostridia S TIGRFAM competence damage-inducible protein CinA cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_79709_2 420324.KI911996_gene7808 3.18e-25 107.0 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,1JVB0@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM Phosphoglycerate mutase sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_124919_1 1396858.Q666_03595 6.43e-25 104.0 COG0730@1|root,COG0730@2|Bacteria,1RAG9@1224|Proteobacteria,1S2RX@1236|Gammaproteobacteria,466JN@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane transporter protein - - - - - - - - - - - - TauE k59_59984_1 1182590.BN5_00551 4.8e-51 173.0 COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,1S3SX@1236|Gammaproteobacteria,1YIH1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_59984_2 56780.SYN_01486 3.75e-48 162.0 COG0791@1|root,COG3087@1|root,COG0791@2|Bacteria,COG3087@2|Bacteria,1N0EE@1224|Proteobacteria,42V3C@68525|delta/epsilon subdivisions,2WRIP@28221|Deltaproteobacteria,2MSJ0@213462|Syntrophobacterales 28221|Deltaproteobacteria M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,SPOR k59_40642_1 215803.DB30_1314 3.7e-25 111.0 COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG5000@2|Bacteria,1RGKE@1224|Proteobacteria,43BX6@68525|delta/epsilon subdivisions,2WNRP@28221|Deltaproteobacteria,2YTVD@29|Myxococcales 28221|Deltaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HisKA,PAS,PAS_4 k59_53382_1 1485545.JQLW01000009_gene138 2.43e-110 334.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria 1224|Proteobacteria KLT serine threonine protein kinase prkC - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2,Pkinase k59_163673_1 1049564.TevJSym_cb00030 2.82e-11 61.6 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1J72N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG3030 Protein affecting phage T7 exclusion by the F plasmid fxsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 - ko:K07113 - - - - ko00000 - - - FxsA k59_163673_2 1049564.TevJSym_ac01750 5.81e-146 414.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J5NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Polyphosphate kinase 2 (PPK2) ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_150845_1 1049564.TevJSym_ai00520 4.08e-70 234.0 COG2199@1|root,COG4223@1|root,COG2199@2|Bacteria,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_183296_1 314278.NB231_00235 2.43e-79 246.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1SYQK@1236|Gammaproteobacteria,1X0BB@135613|Chromatiales 135613|Chromatiales M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_1400_1 1232683.ADIMK_2175 1e-06 55.8 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_144432_1 439235.Dalk_3080 1.7e-43 147.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2MJMY@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_195722_1 673860.AciM339_0903 2.52e-23 102.0 COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota,3F2ZE@33867|unclassified Euryarchaeota 28890|Euryarchaeota S Putative small multi-drug export protein - - - - - - - - - - - - Sm_multidrug_ex k59_124921_1 261292.Nit79A3_0232 2.14e-91 306.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_16,TonB_dep_Rec k59_1591_1 177437.HRM2_28730 3.55e-102 314.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2MHX0@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_92772_1 1307761.L21SP2_1853 3.99e-13 68.2 COG1469@1|root,COG1469@2|Bacteria,2J6BM@203691|Spirochaetes 203691|Spirochaetes S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_92772_2 933262.AXAM01000057_gene1540 5.02e-62 197.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,42MMC@68525|delta/epsilon subdivisions,2WN12@28221|Deltaproteobacteria,2MI8G@213118|Desulfobacterales 28221|Deltaproteobacteria D Belongs to the TtcA family ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_86088_1 1121441.AUCX01000002_gene2876 9.68e-19 80.9 COG1550@1|root,COG1550@2|Bacteria,1NEW6@1224|Proteobacteria,42V11@68525|delta/epsilon subdivisions,2WSHI@28221|Deltaproteobacteria,2MC56@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_60211_1 1121935.AQXX01000002_gene5834 5.33e-84 251.0 COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,1S08N@1236|Gammaproteobacteria,1XMAS@135619|Oceanospirillales 135619|Oceanospirillales L Resolvase, N terminal domain - - - - - - - - - - - - Resolvase k59_60211_2 398767.Glov_3698 6.31e-220 642.0 COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,42YHN@68525|delta/epsilon subdivisions,2WTYP@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase Tn3 family protein - - - - - - - - - - - - DDE_Tnp_Tn3,DUF4158 k59_125215_1 880073.Calab_1785 6.3e-97 305.0 COG0709@1|root,COG1104@1|root,COG0709@2|Bacteria,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine selD - 2.7.9.3,2.8.1.7 ko:K01008,ko:K04487 ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122 - R03595,R07460,R11528,R11529 RC00002,RC01789,RC02313,RC02878 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - AIRS,AIRS_C,Aminotran_5 k59_112108_1 1521187.JPIM01000061_gene990 6.67e-157 458.0 COG1960@1|root,COG1960@2|Bacteria,2G7V8@200795|Chloroflexi,375QJ@32061|Chloroflexia 32061|Chloroflexia C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_21432_1 443143.GM18_1679 9.53e-67 222.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,43TZI@69541|Desulfuromonadales 28221|Deltaproteobacteria KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_189906_2 298386.PBPRA3420 3.85e-110 330.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XT9Q@135623|Vibrionales 135623|Vibrionales F Belongs to the GARS family purD GO:0003674,GO:0003824,GO:0004637,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_1593_3 1121935.AQXX01000054_gene2934 5.9e-12 63.5 COG1196@1|root,COG1196@2|Bacteria,1QZ12@1224|Proteobacteria,1T3ZD@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Plasmid replication region DNA-binding N-term - - - - - - - - - - - - KfrA_N k59_47224_1 1121396.KB892913_gene165 3.65e-32 127.0 COG0466@1|root,COG0466@2|Bacteria,1R6HF@1224|Proteobacteria,42QHZ@68525|delta/epsilon subdivisions,2WJNZ@28221|Deltaproteobacteria,2MMKV@213118|Desulfobacterales 28221|Deltaproteobacteria O Subunit ChlI of Mg-chelatase - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,Lon_C,Response_reg k59_47224_2 1144313.PMI10_03252 1.13e-07 56.2 COG4251@1|root,COG4251@2|Bacteria,4NE3J@976|Bacteroidetes,1HXNX@117743|Flavobacteriia,2NU9V@237|Flavobacterium 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_202853_2 1395571.TMS3_0115040 1.61e-40 148.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon hdfR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_53578_1 1049564.TevJSym_bh00320 4.47e-159 451.0 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,1RYWC@1236|Gammaproteobacteria,1JB8E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_53578_2 754476.Q7A_296 2.97e-18 80.9 COG1357@1|root,COG1357@2|Bacteria,1MZAT@1224|Proteobacteria,1S9V6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pentapeptide - - - - - - - - - - - - Pentapeptide k59_53578_3 631362.Thi970DRAFT_01573 8.45e-33 127.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_98835_1 1123393.KB891329_gene1018 1.14e-14 85.9 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2W9ZC@28216|Betaproteobacteria,1KRZX@119069|Hydrogenophilales 119069|Hydrogenophilales M RHS protein - - - - - - - - - - - - RHS,RHS_repeat k59_105439_1 1120973.AQXL01000096_gene3002 1.46e-21 95.9 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1TSMG@1239|Firmicutes,4HBFH@91061|Bacilli,279IG@186823|Alicyclobacillaceae 91061|Bacilli S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_105439_4 1454004.AW11_03269 0.0 1109.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria 28216|Betaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_170650_1 1122604.JONR01000003_gene1380 1.06e-14 79.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1S0J1@1236|Gammaproteobacteria,1X67N@135614|Xanthomonadales 135614|Xanthomonadales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K13487 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - HAMP,MCPsignal k59_112113_1 1116472.MGMO_17c00070 1.54e-21 87.0 COG5572@1|root,COG5572@2|Bacteria,1PZ3H@1224|Proteobacteria,1SG80@1236|Gammaproteobacteria,1XGP5@135618|Methylococcales 135618|Methylococcales S Predicted integral membrane protein (DUF2282) - - - - - - - - - - - - DUF2282 k59_112113_2 1454202.PPBDW_20055___1 2.53e-67 214.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XTSI@135623|Vibrionales 135623|Vibrionales S protein conserved in bacteria - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_60212_1 335543.Sfum_1396 6.36e-135 412.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_1 k59_137729_1 1121935.AQXX01000112_gene5767 1.21e-11 65.5 COG2227@1|root,COG2227@2|Bacteria,1QYR4@1224|Proteobacteria,1T42Z@1236|Gammaproteobacteria,1XRWH@135619|Oceanospirillales 135619|Oceanospirillales H ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_23 k59_86094_1 1265505.ATUG01000001_gene3648 3.79e-34 120.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42W3M@68525|delta/epsilon subdivisions,2WP9C@28221|Deltaproteobacteria,2MK7D@213118|Desulfobacterales 28221|Deltaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_86094_2 335543.Sfum_2164 2.61e-135 410.0 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MR04@213462|Syntrophobacterales 28221|Deltaproteobacteria S 7TM-HD extracellular - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_73239_1 1123376.AUIU01000016_gene222 1.83e-17 81.6 COG1053@1|root,COG1053@2|Bacteria,3J0ZM@40117|Nitrospirae 40117|Nitrospirae C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_73239_2 1162668.LFE_1242 9.87e-34 120.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K21903 - - - - ko00000,ko03000 - - - HTH_20,HTH_24 k59_157702_1 1123401.JHYQ01000001_gene1783 1.12e-80 251.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales 72273|Thiotrichales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_112376_1 1125863.JAFN01000001_gene1434 1.61e-33 117.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_112376_2 349161.Dred_1950 4.04e-06 48.1 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,260DE@186807|Peptococcaceae 186801|Clostridia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_86424_1 1123371.ATXH01000016_gene1829 5.41e-36 135.0 COG2204@1|root,COG2204@2|Bacteria,2GH05@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_86424_2 1167006.UWK_02620 3.08e-44 160.0 COG0466@1|root,COG0466@2|Bacteria,1R6HF@1224|Proteobacteria,42QHZ@68525|delta/epsilon subdivisions,2WJNZ@28221|Deltaproteobacteria,2MMKV@213118|Desulfobacterales 28221|Deltaproteobacteria O Subunit ChlI of Mg-chelatase - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,Lon_C,Response_reg k59_14699_2 1121405.dsmv_1241 5.82e-25 96.7 COG2512@1|root,COG2512@2|Bacteria,1NB2J@1224|Proteobacteria,42VKV@68525|delta/epsilon subdivisions,2WS56@28221|Deltaproteobacteria,2MM6F@213118|Desulfobacterales 28221|Deltaproteobacteria S Transcriptional regulator - - - - - - - - - - - - - k59_164134_1 555088.DealDRAFT_1474 3.82e-42 147.0 COG2386@1|root,COG2386@2|Bacteria,1VDEP@1239|Firmicutes,24NJK@186801|Clostridia 186801|Clostridia O cytochrome c-type biogenesis protein CcmB - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_125591_1 706587.Desti_5385 8.36e-55 192.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_119085_1 1049564.TevJSym_ax00090 2.72e-274 765.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1J4ET@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_119085_3 1049564.TevJSym_ax00110 1.33e-77 237.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_93449_1 1121403.AUCV01000002_gene540 1.21e-121 355.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria,2MHTE@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_8925_1 933262.AXAM01000057_gene1547 3.95e-22 90.1 2DXKB@1|root,32V3M@2|Bacteria,1N4K4@1224|Proteobacteria,42UFV@68525|delta/epsilon subdivisions,2WQ77@28221|Deltaproteobacteria,2MKIC@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - ko:K09986 - - - - ko00000 - - - - k59_8925_2 1353276.JADR01000002_gene2084 2.17e-12 68.9 COG1076@1|root,COG1076@2|Bacteria,4NF1B@976|Bacteroidetes,1HYUI@117743|Flavobacteriia 976|Bacteroidetes O DnaJ domain protein - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_47682_1 1499967.BAYZ01000095_gene4193 3.31e-55 190.0 COG0737@1|root,COG0737@2|Bacteria,2NQR9@2323|unclassified Bacteria 2|Bacteria F Belongs to the 5'-nucleotidase family ushA - 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Cytochrome_C554,Metallophos k59_14889_2 1535422.ND16A_3019 3.17e-17 75.5 COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,2Q78D@267889|Colwelliaceae 1236|Gammaproteobacteria S DNA gyrase inhibitor YacG yacG GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372 - ko:K09862 - - - - ko00000 - - - YacG k59_93453_1 1198232.CYCME_2050 6.09e-55 175.0 COG0720@1|root,COG0720@2|Bacteria,1RKBW@1224|Proteobacteria,1S7FX@1236|Gammaproteobacteria 1236|Gammaproteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_190427_1 768671.ThimaDRAFT_1579 1.61e-118 364.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_60744_1 517418.Ctha_2627 8.27e-21 97.1 COG0557@1|root,COG0557@2|Bacteria,1FDF5@1090|Chlorobi 1090|Chlorobi J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_164317_1 1049564.TevJSym_ac01270 5.42e-53 171.0 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1J6UK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0030674,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042221,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0045229,GO:0046677,GO:0050896,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0060090,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_164317_2 1049564.TevJSym_ac01260 1.32e-65 201.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1J6EA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_151607_2 1049564.TevJSym_ai00280 2.35e-22 93.6 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl k59_119365_1 999141.GME_10351 3.01e-08 53.9 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1XHVC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_119365_2 765911.Thivi_2592 3.46e-96 293.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_125788_1 289377.HL41_02700 4.17e-37 139.0 COG1489@1|root,COG1833@1|root,COG1489@2|Bacteria,COG1833@2|Bacteria,2GHI5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Sugar fermentation stimulation protein - - - ko:K06206 - - - - ko00000 - - - DUF123,SfsA k59_184245_1 1049564.TevJSym_bf00220 5.96e-250 694.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1J707@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Metal dependent phosphohydrolases with conserved 'HD' motif. dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_177542_1 1123269.NX02_19670 6.31e-102 311.0 COG0863@1|root,COG0863@2|Bacteria,1R3SK@1224|Proteobacteria,2U1D7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Pfam:Methyltransf_26 - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_145143_1 1049564.TevJSym_au00110 8.28e-66 202.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1J5XB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_41629_1 207559.Dde_1522 7.63e-10 64.3 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,43BMJ@68525|delta/epsilon subdivisions,2WUEV@28221|Deltaproteobacteria,2MH9E@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,dCache_1 k59_132283_1 1479237.JMLY01000001_gene3642 4.04e-62 200.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,46C13@72275|Alteromonadaceae 1236|Gammaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07098 - - - - ko00000 - - - Metallophos,Metallophos_2 k59_157929_1 1124780.ANNU01000043_gene331 5.75e-82 253.0 COG1073@1|root,COG1073@2|Bacteria,4NMZQ@976|Bacteroidetes 976|Bacteroidetes S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_93464_1 439235.Dalk_1444 3.02e-37 139.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42NTH@68525|delta/epsilon subdivisions,2WJ8N@28221|Deltaproteobacteria,2MIMX@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_8937_1 558169.AGAV01000014_gene1681 2.23e-06 53.9 COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli 91061|Bacilli P Membrane - - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - CitMHS k59_47694_1 2340.JV46_08150 2.74e-185 554.0 COG3291@1|root,COG3291@2|Bacteria,1PDUK@1224|Proteobacteria,1S8QS@1236|Gammaproteobacteria,1JBTK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PKD domain - - - - - - - - - - - - PKD,PPC,Peptidase_M43 k59_67102_1 1286632.P278_20120 1.54e-38 140.0 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HZ28@117743|Flavobacteriia 976|Bacteroidetes L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_41639_1 1049564.TevJSym_as00080 2.38e-82 248.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1J4YB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126,SHOCT k59_145154_1 760011.Spico_0620 1.73e-16 76.3 COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes 203691|Spirochaetes S PFAM Uncharacterised protein family (UPF0153) - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_145154_2 335543.Sfum_1957 3.64e-10 60.1 2EUFT@1|root,33MY2@2|Bacteria,1NMCP@1224|Proteobacteria,42XWX@68525|delta/epsilon subdivisions,2WTB3@28221|Deltaproteobacteria,2MQQ5@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_54030_2 485916.Dtox_1820 4.9e-222 622.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,2644N@186807|Peptococcaceae 186801|Clostridia L Group II intron, maturase-specific domain - - - - - - - - - - - - GIIM,RVT_1 k59_196489_2 483219.LILAB_31195 6.92e-50 173.0 COG4965@1|root,COG4965@2|Bacteria,1MYNG@1224|Proteobacteria,42UK9@68525|delta/epsilon subdivisions,2WQT2@28221|Deltaproteobacteria 28221|Deltaproteobacteria U flp pilus assembly protein - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_60766_1 582744.Msip34_2200 5.76e-35 132.0 28J59@1|root,2Z915@2|Bacteria,1MWN5@1224|Proteobacteria,2VZ9K@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_2050_1 398767.Glov_1611 5.2e-47 166.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,43SUM@69541|Desulfuromonadales 28221|Deltaproteobacteria C pyridine nucleotide-disulphide oxidoreductase dimerisation region lpdA-1 - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_22102_1 396588.Tgr7_2005 1.8e-137 401.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_125804_4 742741.HMPREF9475_04098 5.38e-20 90.1 COG3541@1|root,COG3541@2|Bacteria,1TT57@1239|Firmicutes,24EJG@186801|Clostridia,221M1@1506553|Lachnoclostridium 186801|Clostridia S Predicted nucleotidyltransferase - - - ko:K07074 - - - - ko00000 - - - Nuc-transf k59_184266_1 237368.SCABRO_01864 5.53e-100 303.0 COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes 203682|Planctomycetes Q Belongs to the MlaE permease family - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_41645_1 330214.NIDE1676 2.21e-15 76.6 COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae 40117|Nitrospirae O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase,ChlI,Lon_C k59_86650_1 641491.DND132_3165 1.23e-17 89.7 COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1Q0K1@1224|Proteobacteria,43EQ6@68525|delta/epsilon subdivisions,2X9KG@28221|Deltaproteobacteria,2MERK@213115|Desulfovibrionales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_119387_1 566466.NOR53_1227 4.88e-91 281.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J84T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C COG1012 NAD-dependent aldehyde dehydrogenases - - - - - - - - - - - - Aldedh k59_34911_1 933262.AXAM01000011_gene1755 8.86e-63 211.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,2MJ25@213118|Desulfobacterales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_9,Pyr_redox_2 k59_2051_1 467661.RKLH11_3891 1.73e-125 373.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria 1224|Proteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_203341_1 396588.Tgr7_0034 3.86e-165 493.0 COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WZVV@135613|Chromatiales 135613|Chromatiales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - 4HB_MCP_1,EAL,GGDEF,PAS,PAS_4 k59_22103_2 1547445.LO80_04355 1.66e-43 148.0 COG3153@1|root,COG3153@2|Bacteria,1QU4W@1224|Proteobacteria 1224|Proteobacteria S acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_157945_1 946483.Cenrod_2340 1.22e-35 132.0 COG3039@1|root,COG3039@2|Bacteria,1R64B@1224|Proteobacteria,2W09R@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_41648_1 243277.VC_2132 1.13e-22 95.1 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1XSQJ@135623|Vibrionales 135623|Vibrionales N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliG GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_41648_3 1049564.TevJSym_ac00730 1.94e-29 115.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1J55H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_28330_1 1469607.KK073768_gene2634 2.31e-136 410.0 COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,1HMIZ@1161|Nostocales 1117|Cyanobacteria LV Group II intron, maturase-specific domain - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,HNH,RVT_1,RVT_N k59_73430_1 96561.Dole_1524 1.64e-84 259.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2MI27@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_126627_1 1121405.dsmv_1373 7.59e-35 130.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,42MX3@68525|delta/epsilon subdivisions,2WKI4@28221|Deltaproteobacteria,2MI7Y@213118|Desulfobacterales 28221|Deltaproteobacteria M Transglycosylase SLT domain - - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_158515_1 1121405.dsmv_0480 1.3e-47 165.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_80952_1 765911.Thivi_3300 1.39e-99 290.0 COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,1S3TG@1236|Gammaproteobacteria,1X27P@135613|Chromatiales 135613|Chromatiales C Adenosine-5'-phosphosulfate reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4_9 k59_80952_2 765913.ThidrDRAFT_2078 1.11e-28 114.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales 135613|Chromatiales C reductase, alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_22571_1 189753.AXAS01000033_gene2792 2.58e-51 172.0 COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,2U71S@28211|Alphaproteobacteria,3JUB2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_22571_2 589873.EP13_10875 1.78e-51 180.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,465RV@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_22571_4 717774.Marme_3932 4.69e-66 207.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1XJPZ@135619|Oceanospirillales 135619|Oceanospirillales S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_22571_5 266264.Rmet_5070 9.61e-108 327.0 COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,2WHAV@28216|Betaproteobacteria 28216|Betaproteobacteria Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_22571_7 1158292.JPOE01000005_gene434 3.17e-109 341.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,1KN51@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase yfhK - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_48316_1 94122.Shewana3_2920 7.14e-40 144.0 2DMU5@1|root,32TQ2@2|Bacteria,1N4J1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_138780_1 880072.Desac_1833 5.44e-89 269.0 COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MQCI@213462|Syntrophobacterales 28221|Deltaproteobacteria D PFAM CobQ CobB MinD ParA nucleotide binding domain cooC - - ko:K07321 - - - - ko00000 - - - CbiA k59_2556_1 1232437.KL662014_gene1293 4.05e-42 157.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MINP@213118|Desulfobacterales 28221|Deltaproteobacteria NT PFAM chemotaxis sensory transducer - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HBM,MCPsignal k59_203870_1 1131269.AQVV01000022_gene2245 1.28e-85 271.0 COG0815@1|root,COG0815@2|Bacteria 2|Bacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_145679_1 451705.A9Q1V1_9CAUD 4.02e-05 49.3 4QC7Q@10239|Viruses,4QXT6@35237|dsDNA viruses no RNA stage,4QTR3@28883|Caudovirales,4QKCW@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_145679_3 1027273.GZ77_21170 1.23e-155 454.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,1S09Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_145679_4 1247963.JPHU01000005_gene409 3.58e-08 58.5 2DQ0G@1|root,3347W@2|Bacteria,1N9PC@1224|Proteobacteria,2UIWC@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_145679_7 224308.BSU26250 0.000162 43.5 COG4570@1|root,COG4570@2|Bacteria,1VF2H@1239|Firmicutes,4HJ0V@91061|Bacilli,1ZHF6@1386|Bacillus 91061|Bacilli L Endodeoxyribonuclease RusA rusA - - - - - - - - - - - RusA k59_28814_1 880073.Calab_2813 1.63e-38 147.0 COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria 2|Bacteria S 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_120049_1 743974.MBO_07533 1.83e-29 115.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,3NJI9@468|Moraxellaceae 1236|Gammaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_94221_1 1049564.TevJSym_ad00780 6.3e-145 425.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_184786_3 1136163.M565_ctg1P1162 1.98e-89 265.0 COG0454@1|root,COG0456@2|Bacteria,1QTY5@1224|Proteobacteria,1S6M9@1236|Gammaproteobacteria,1Y36G@135623|Vibrionales 135623|Vibrionales K Acetyltransferase (GNAT) domain - - - ko:K03825 - - - - ko00000,ko01000 - - - Acetyltransf_1 k59_184786_4 298386.PBPRA1917 6.21e-96 283.0 COG1896@1|root,COG1896@2|Bacteria,1MXEZ@1224|Proteobacteria,1RRQQ@1236|Gammaproteobacteria,1XUSC@135623|Vibrionales 135623|Vibrionales S hydrolases of HD superfamily - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_164875_1 323261.Noc_1548 4.86e-123 363.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1WW1A@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_164875_2 247633.GP2143_06883 2.24e-35 128.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1J55C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) rimK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_152060_1 1125863.JAFN01000001_gene1251 5.26e-50 165.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WRZW@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_132886_1 267608.RSc0095 1.53e-25 103.0 COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2VRBW@28216|Betaproteobacteria 28216|Betaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_132886_3 494416.AYXN01000029_gene1704 1.01e-48 161.0 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S66I@1236|Gammaproteobacteria,3NJMU@468|Moraxellaceae 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain IV02_27405 - - - - - - - - - - - YkuD k59_132886_6 118161.KB235922_gene3544 1.87e-53 172.0 COG5470@1|root,COG5470@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1330 k59_106631_1 349124.Hhal_0067 5.69e-16 76.6 COG1143@1|root,COG2878@1|root,COG1143@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_106631_2 94122.Shewana3_3158 6.7e-12 63.9 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria,2Q9DY@267890|Shewanellaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_87220_1 56780.SYN_01946 2.6e-80 244.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MQC6@213462|Syntrophobacterales 28221|Deltaproteobacteria EH TIGRFAM glutamine amidotransferase of anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2496 GATase k59_35546_1 335543.Sfum_1590 3.95e-85 266.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MR5R@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_99833_1 880072.Desac_0991 1.64e-38 137.0 COG1913@1|root,COG1913@2|Bacteria,1NEU5@1224|Proteobacteria,42WCP@68525|delta/epsilon subdivisions,2X5BA@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase family M54 - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 k59_191066_3 1249627.D779_1871 6.8e-08 51.6 2CHZ5@1|root,32Z62@2|Bacteria,1N8C1@1224|Proteobacteria,1SG1A@1236|Gammaproteobacteria,1WZ73@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_191066_4 1121937.AUHJ01000001_gene456 1.73e-06 49.3 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,465AY@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_61425_1 1160721.RBI_II00235 3.99e-24 99.4 COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24HZR@186801|Clostridia,3WJQC@541000|Ruminococcaceae 186801|Clostridia S phosphoglycolate phosphatase, bacterial - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_132887_1 298654.FraEuI1c_6846 1.5e-29 119.0 COG0270@1|root,COG0270@2|Bacteria,2I8R8@201174|Actinobacteria 201174|Actinobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_94225_1 700598.Niako_5919 2.97e-30 120.0 COG3547@1|root,COG3547@2|Bacteria,4NHYP@976|Bacteroidetes,1J0CZ@117747|Sphingobacteriia 976|Bacteroidetes L COGs COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_42350_1 1049564.TevJSym_ae01150 2.86e-80 248.0 COG0151@1|root,COG0151@2|Bacteria,1RB1U@1224|Proteobacteria,1S9GX@1236|Gammaproteobacteria 1236|Gammaproteobacteria F ATP-grasp domain - - - - - - - - - - - - - k59_67857_1 1131553.JIBI01000019_gene496 2.33e-86 273.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,371WD@32003|Nitrosomonadales 28216|Betaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10,6.3.2.13 ko:K01929,ko:K15792 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R02788,R04573,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_67857_2 1224318.DT73_07485 9.16e-53 181.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_152064_1 573370.DMR_01320 1.48e-62 200.0 COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42S1Y@68525|delta/epsilon subdivisions,2WP4J@28221|Deltaproteobacteria,2M9EU@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM AraC-type transcriptional regulator - - - - - - - - - - - - AraC_N,HTH_18 k59_120053_1 933262.AXAM01000050_gene3482 4.75e-167 493.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2MHTZ@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC transporter transmembrane region - - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_164881_1 335543.Sfum_1424 2.71e-64 211.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MQ90@213462|Syntrophobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_3528 Seryl_tRNA_N,tRNA-synt_2b k59_15424_1 880072.Desac_2468 2.97e-40 143.0 COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria,2MRQ9@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_145690_1 1249627.D779_0219 3.86e-43 152.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1WW96@135613|Chromatiales 135613|Chromatiales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_145690_2 1266914.ATUK01000017_gene549 8.78e-90 272.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales 135613|Chromatiales M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_87224_1 941449.dsx2_2883 1.38e-172 494.0 COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,42NT6@68525|delta/epsilon subdivisions,2WJ9R@28221|Deltaproteobacteria,2M8W4@213115|Desulfovibrionales 28221|Deltaproteobacteria S family UPF0324 - - - - - - - - - - - - Cons_hypoth698 k59_203879_3 998674.ATTE01000001_gene4334 1.41e-97 286.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,460F6@72273|Thiotrichales 72273|Thiotrichales H May be involved in the biosynthesis of molybdopterin - - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_2565_2 1049564.TevJSym_bv00110 3.91e-311 862.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1J5PE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_2565_3 1049564.TevJSym_bv00120 2.56e-25 95.1 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria,1JBJK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_127021_1 56780.SYN_01709 3.44e-122 356.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MQBF@213462|Syntrophobacterales 28221|Deltaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_120368_1 768671.ThimaDRAFT_1238 5.5e-52 189.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X0HH@135613|Chromatiales 135613|Chromatiales T Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB,EAL,GGDEF k59_120368_2 946483.Cenrod_1931 1.07e-58 193.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,4AD3Y@80864|Comamonadaceae 28216|Betaproteobacteria T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_139023_1 1298593.TOL_0761 2.65e-62 211.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1XIC0@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_139023_2 1049564.TevJSym_au00420 1.29e-27 100.0 2CHMQ@1|root,33I75@2|Bacteria,1NQE2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_139023_3 1120970.AUBZ01000001_gene3739 1.69e-49 174.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,464A9@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_15682_1 640081.Dsui_3002 2.33e-30 123.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K13040 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_87436_1 933262.AXAM01000027_gene2088 1.12e-43 145.0 COG1810@1|root,COG1810@2|Bacteria,1RG9Q@1224|Proteobacteria,42S52@68525|delta/epsilon subdivisions,2WNTC@28221|Deltaproteobacteria,2MK0C@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function - - - - - - - - - - - - DUF166 k59_191272_1 338966.Ppro_1409 1.78e-114 336.0 COG2518@1|root,COG2518@2|Bacteria,1RC4G@1224|Proteobacteria,43E9Z@68525|delta/epsilon subdivisions,2X7S5@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_31 k59_191272_2 56780.SYN_02213 5.55e-33 127.0 COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_171899_1 335543.Sfum_0115 1.6e-100 303.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,2MQT4@213462|Syntrophobacterales 28221|Deltaproteobacteria C ferredoxin oxidoreductase alpha subunit - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_94663_1 436114.SYO3AOP1_0465 0.00013 47.4 COG0664@1|root,COG0664@2|Bacteria,2G47S@200783|Aquificae 200783|Aquificae K Transcriptional regulator, Crp Fnr family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_204137_1 880072.Desac_0858 5.25e-120 350.0 COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,42TWC@68525|delta/epsilon subdivisions,2WQ80@28221|Deltaproteobacteria,2MR2I@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_197308_1 96561.Dole_0628 2.36e-16 73.9 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VWC@68525|delta/epsilon subdivisions,2WS5S@28221|Deltaproteobacteria,2MKV4@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_42750_1 1038859.AXAU01000030_gene6763 3.84e-24 107.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_165157_1 472759.Nhal_2889 2.71e-37 132.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,1SEYJ@1236|Gammaproteobacteria,1X2JC@135613|Chromatiales 135613|Chromatiales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_165157_2 472759.Nhal_2890 2.72e-73 223.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WXMA@135613|Chromatiales 135613|Chromatiales T Chemotaxis sensory transducer - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 k59_9867_1 1192034.CAP_0825 1.53e-09 70.9 COG2133@1|root,COG3055@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - - k59_171901_1 631362.Thi970DRAFT_03643 1.55e-71 238.0 COG4191@1|root,COG4191@2|Bacteria,1MXRR@1224|Proteobacteria,1RQ1E@1236|Gammaproteobacteria,1WW44@135613|Chromatiales 135613|Chromatiales T nitrogen fixation negative regulator NifL - - - - - - - - - - - - HATPase_c,PAS,PAS_9 k59_106960_1 1192034.CAP_6959 2.16e-36 140.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,2YUZJ@29|Myxococcales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_127036_1 635013.TherJR_0997 7.91e-35 136.0 COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_8,PAS_9 k59_146016_2 595536.ADVE02000001_gene3060 4.64e-190 563.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2TU4W@28211|Alphaproteobacteria,36Z5E@31993|Methylocystaceae 28211|Alphaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_2848_1 1443113.LC20_01830 5.16e-10 63.5 COG2131@1|root,COG2131@2|Bacteria,1QDAH@1224|Proteobacteria,1RRDW@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Deoxycytidylate deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_191282_1 690850.Desaf_1519 1.49e-51 172.0 COG1852@1|root,COG1852@2|Bacteria,1RAI2@1224|Proteobacteria,42QUD@68525|delta/epsilon subdivisions,2WMQ5@28221|Deltaproteobacteria,2M8MW@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function DUF116 - - - ko:K09729 - - - - ko00000 - - - DUF116 k59_120374_1 1395571.TMS3_0106935 2.99e-33 128.0 COG0834@1|root,COG0834@2|Bacteria,1RH2S@1224|Proteobacteria,1S84G@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_120374_2 1499967.BAYZ01000009_gene5334 5.84e-11 73.6 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,PocR k59_100121_1 2340.JV46_26220 7.82e-78 244.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1J4U5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436 S4,tRNA-synt_1b k59_197319_1 439235.Dalk_3266 5.84e-81 269.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_106964_1 439235.Dalk_0583 7.19e-80 245.0 COG0577@1|root,COG0577@2|Bacteria,1RC4T@1224|Proteobacteria,42QZ6@68525|delta/epsilon subdivisions,2WMU4@28221|Deltaproteobacteria,2MJPK@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX k59_106964_2 1232437.KL662011_gene1507 2.04e-21 92.8 COG0726@1|root,COG0726@2|Bacteria,1R5QW@1224|Proteobacteria,42R0U@68525|delta/epsilon subdivisions,2WN0F@28221|Deltaproteobacteria,2MJIM@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Polysaccharide deacetylase - - - - - - - - - - - - DUF2334,Polysacc_deac_1 k59_113410_1 269797.Mbar_A3057 9.3e-41 140.0 COG1513@1|root,arCOG01488@2157|Archaea,2XX3Y@28890|Euryarchaeota,2NA2H@224756|Methanomicrobia 224756|Methanomicrobia F MafB19-like deaminase - - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k59_113410_2 1049564.TevJSym_al00300 6.54e-148 426.0 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,1J4E1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_113410_3 68260.JOAY01000028_gene4097 4.06e-07 54.7 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_204141_1 886293.Sinac_4765 1.45e-10 73.9 COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,2J50K@203682|Planctomycetes 203682|Planctomycetes U Pkd domain containing protein - - 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - - k59_191284_1 644282.Deba_2839 6.02e-13 67.8 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.3 ko:K00124,ko:K00335,ko:K18331 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_191284_2 439235.Dalk_5090 1.72e-113 357.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_165172_1 156889.Mmc1_1519 5.3e-41 155.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K exporters of the RND superfamily MA20_16090 - - ko:K07003 - - - - ko00000 - - - MMPL k59_171914_1 1178482.BJB45_02405 1.11e-113 338.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XHS2@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamine synthetase family - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_48679_1 1168065.DOK_15444 2.39e-40 147.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1J50R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_48679_2 314278.NB231_10358 4.32e-20 100.0 COG0745@1|root,COG0745@2|Bacteria,1QW3Q@1224|Proteobacteria,1T2RQ@1236|Gammaproteobacteria,1X2NX@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - Response_reg k59_197322_1 929712.KI912613_gene3471 1.7e-14 79.3 COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4CPSV@84995|Rubrobacteria 84995|Rubrobacteria L May be involved in recombinational repair of damaged DNA - - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_9879_1 1304888.ATWF01000001_gene1124 7.31e-18 82.4 COG3118@1|root,COG3118@2|Bacteria,2GFRI@200930|Deferribacteres 200930|Deferribacteres O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_191288_1 96561.Dole_2692 1.38e-29 119.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,2MHZ5@213118|Desulfobacterales 28221|Deltaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_48680_1 933262.AXAM01000018_gene1005 4.95e-150 436.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_152323_2 519989.ECTPHS_00809 4.27e-51 166.0 COG1569@1|root,COG1569@2|Bacteria,1NJ68@1224|Proteobacteria 1224|Proteobacteria S nucleic acid-binding protein, contains PIN domain - - - - - - - - - - - - PIN_3 k59_152323_3 519989.ECTPHS_00804 4.49e-30 108.0 2EFWZ@1|root,339P8@2|Bacteria,1Q1AB@1224|Proteobacteria,1SVKF@1236|Gammaproteobacteria,1X20G@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_133164_1 1218084.BBJK01000149_gene7525 2.14e-31 125.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_120387_1 706587.Desti_5261 1.77e-28 114.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MRXQ@213462|Syntrophobacterales 28221|Deltaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_54823_1 335543.Sfum_0068 4.23e-76 249.0 COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_68240_1 1345697.M493_03980 4.98e-34 125.0 COG2181@1|root,COG2181@2|Bacteria,1UY97@1239|Firmicutes,4HD9W@91061|Bacilli,1WG6G@129337|Geobacillus 91061|Bacilli C Nitrate reductase gamma subunit narI - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam k59_94698_2 1121405.dsmv_3019 1.77e-59 195.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2MJBW@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_120389_1 1242864.D187_004407 1.91e-38 140.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria P TIGRFAM phosphate binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_15711_1 574966.KB898652_gene1789 6.68e-34 124.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1XHTY@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_15711_2 1049564.TevJSym_ba00180 3.4e-38 135.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1J4Y4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_191294_1 70601.3257433 1.87e-34 134.0 COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,242U3@183968|Thermococci 183968|Thermococci C aldehyde ferredoxin oxidoreductase aor - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_61815_4 1208321.D104_07060 4.52e-37 140.0 COG1266@1|root,COG1266@2|Bacteria,1P0IE@1224|Proteobacteria,1RS9M@1236|Gammaproteobacteria,1XMKU@135619|Oceanospirillales 135619|Oceanospirillales S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_61815_5 521719.ATXQ01000002_gene2595 1.92e-79 275.0 COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,1T1GM@1236|Gammaproteobacteria,1YFQY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_61815_8 344747.PM8797T_11074 3.4e-61 228.0 COG0004@1|root,COG5002@1|root,COG0004@2|Bacteria,COG5002@2|Bacteria,2IYBN@203682|Planctomycetes 203682|Planctomycetes P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,HATPase_c,HisKA k59_204146_1 530564.Psta_1836 1.09e-148 441.0 COG3519@1|root,COG3519@2|Bacteria,2IYES@203682|Planctomycetes 203682|Planctomycetes S TIGRFAM type VI secretion protein, VC_A0110 family - - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_204146_2 765911.Thivi_2284 1.24e-127 375.0 COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,1RRTG@1236|Gammaproteobacteria,1WY56@135613|Chromatiales 135613|Chromatiales S Pfam:T6SS_VasB - - - ko:K11895 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_TssG k59_107216_4 1122604.JONR01000031_gene1257 1.1e-68 229.0 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,1X2X6@135614|Xanthomonadales 135614|Xanthomonadales I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_74346_1 1049564.TevJSym_aw00510 1.55e-196 564.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1J4JH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_113575_1 1049564.TevJSym_ag01000 2.54e-116 345.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_100365_2 349521.HCH_02593 3.22e-31 120.0 28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,1XNCZ@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_152475_1 909663.KI867150_gene440 5.98e-47 173.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRI2@213462|Syntrophobacterales 28221|Deltaproteobacteria T Signal transduction response regulator, receiver domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_10067_1 1049564.TevJSym_aa00370 5.52e-307 855.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1J5G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C k59_159082_1 215803.DB30_5731 4.38e-80 254.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2YUFW@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_94915_1 740709.A10D4_12669 1.07e-63 204.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,1RPEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L protein homolog of phage Mu protein gp30 - - - - - - - - - - - - Phage_Mu_F k59_94915_2 232346.JHQL01000002_gene1065 1.22e-19 85.9 2DI40@1|root,301YS@2|Bacteria,1PYYE@1224|Proteobacteria,1TA5E@1236|Gammaproteobacteria,1XQC8@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_94915_4 161156.JQKW01000012_gene46 5.09e-192 544.0 28KJS@1|root,2ZA4R@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_94915_6 1202962.KB907192_gene2873 3.28e-133 389.0 2CGJI@1|root,2ZADZ@2|Bacteria,1R8KE@1224|Proteobacteria,1RS8Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_94915_9 933262.AXAM01000131_gene2022 3.39e-237 655.0 COG0775@1|root,COG0775@2|Bacteria,1R441@1224|Proteobacteria 1224|Proteobacteria F SEFIR domain - - - - - - - - - - - - SEFIR k59_178707_2 309799.DICTH_1779 7.04e-15 72.4 COG0375@1|root,COG0375@2|Bacteria 2|Bacteria S nickel cation binding hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_146201_2 1401065.HMPREF2130_11445 1.41e-133 382.0 28HX7@1|root,2Z82Y@2|Bacteria,1R7X5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_197508_1 1250006.JHZZ01000001_gene2165 1.01e-33 125.0 COG3124@1|root,COG3124@2|Bacteria,4NHQK@976|Bacteroidetes,1I1CI@117743|Flavobacteriia,3VVDB@52959|Polaribacter 976|Bacteroidetes S Acyl carrier protein phosphodiesterase acpH - - - - - - - - - - - ACP_PD k59_62036_2 314345.SPV1_10376 1.79e-72 256.0 COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,1NWNJ@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - 2.1.1.80,3.1.1.61 ko:K03406,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HWE_HK,HisKA_2,HisKA_3,PAS,PAS_10,PAS_3,PAS_4,PAS_9 k59_100371_1 1121405.dsmv_2130 1.19e-87 270.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2MHWE@213118|Desulfobacterales 28221|Deltaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_185368_1 247490.KSU1_B0100 2.23e-100 304.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_146203_1 760192.Halhy_1923 7.23e-67 218.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes 976|Bacteroidetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_48885_1 1167006.UWK_01299 9.87e-50 176.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_48885_3 573370.DMR_27290 1.69e-72 249.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2M7R7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_74354_1 1267535.KB906767_gene1704 2.46e-11 70.1 COG1032@1|root,COG1032@2|Bacteria,3Y3GN@57723|Acidobacteria,2JI34@204432|Acidobacteriia 204432|Acidobacteriia C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM k59_204324_1 335543.Sfum_3570 5.7e-83 258.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MQI@68525|delta/epsilon subdivisions,2WN1S@28221|Deltaproteobacteria,2MR7B@213462|Syntrophobacterales 28221|Deltaproteobacteria E Aminotransferase class I and II - - 2.6.1.2 ko:K00814 ko00220,ko00250,ko00710,ko01100,ko01120,ko01200,ko01210,ko01230,map00220,map00250,map00710,map01100,map01120,map01200,map01210,map01230 M00171 R00258 RC00006,RC00008 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_3021_1 883126.HMPREF9710_05203 2.09e-36 141.0 COG3210@1|root,COG3501@1|root,COG3210@2|Bacteria,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria,475MH@75682|Oxalobacteraceae 28216|Betaproteobacteria U Phage late control gene D protein (GPD) - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Gp5_C,Phage_GPD k59_197513_1 517418.Ctha_2569 1.62e-101 328.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,1FEWC@1090|Chlorobi 1090|Chlorobi C 2-oxoglutarate dehydrogenase N-terminus - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_204326_1 1249627.D779_0197 1.04e-136 397.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RYJX@1236|Gammaproteobacteria,1WWV5@135613|Chromatiales 135613|Chromatiales G Belongs to the RuBisCO large chain family - - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_133370_1 2340.JV46_19050 4.45e-160 472.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7 k59_133370_2 1469245.JFBG01000038_gene1816 1.98e-28 115.0 2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,1SDPA@1236|Gammaproteobacteria,1X1PN@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3306) - - - - - - - - - - - - DUF3306 k59_133370_3 998674.ATTE01000001_gene872 5.95e-43 147.0 COG0746@1|root,COG0746@2|Bacteria,1NBH1@1224|Proteobacteria,1SDF0@1236|Gammaproteobacteria,4635D@72273|Thiotrichales 72273|Thiotrichales H Protein of unknown function (DUF3305) - - - - - - - - - - - - DUF3305 k59_133370_4 870187.Thini_2554 1.05e-168 482.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,460AH@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_146208_1 1122135.KB893135_gene1031 8.34e-47 165.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_15891_1 439235.Dalk_2566 6.81e-10 58.9 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42R03@68525|delta/epsilon subdivisions,2WMTZ@28221|Deltaproteobacteria,2MJ7X@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - GerE,Response_reg k59_15891_2 439235.Dalk_2567 2.8e-57 199.0 COG3829@1|root,COG4191@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,1RCM9@1224|Proteobacteria,43CS1@68525|delta/epsilon subdivisions,2X7ZN@28221|Deltaproteobacteria,2MPMC@213118|Desulfobacterales 28221|Deltaproteobacteria T Cache domain - - - - - - - - - - - - HATPase_c,dCache_1 k59_81476_2 397291.C804_06302 4.89e-25 112.0 2946W@1|root,2ZRMA@2|Bacteria 2|Bacteria S IMG reference gene - - - - - - - - - - - - - k59_152476_1 1121935.AQXX01000041_gene4651 3.74e-190 583.0 COG2931@1|root,COG4733@1|root,COG2931@2|Bacteria,COG4733@2|Bacteria,1PPUE@1224|Proteobacteria,1RQKW@1236|Gammaproteobacteria,1XR4B@135619|Oceanospirillales 135619|Oceanospirillales Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_152476_4 1242864.D187_001800 1.04e-21 102.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria 28221|Deltaproteobacteria M RHS Repeat - - - - - - - - - - - - DUF4150,RHS,RHS_repeat,Transglut_core k59_87710_1 398767.Glov_2793 7.52e-35 125.0 COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,42PP1@68525|delta/epsilon subdivisions,2WM0A@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein hoxU - 1.6.5.3 ko:K05588 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_10,Fer4_9,NADH-G_4Fe-4S_3 k59_87710_2 429009.Adeg_0332 1.77e-21 94.4 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales 186801|Clostridia C NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding - - 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_178714_2 765911.Thivi_1037 2.34e-117 349.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_178714_3 1049564.TevJSym_ad00730 1.77e-71 219.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1J67X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_197525_1 1123371.ATXH01000013_gene1510 1.33e-67 228.0 COG0550@1|root,COG0550@2|Bacteria,2GH60@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L Bacterial DNA topoisomeraes I ATP-binding domain - - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_68480_1 999541.bgla_2g03850 6.34e-34 130.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1K363@119060|Burkholderiaceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_74370_1 1121448.DGI_0412 3.02e-41 145.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M9IV@213115|Desulfovibrionales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_11173_1 118168.MC7420_4348 3.48e-31 127.0 COG0642@1|root,COG2203@1|root,COG3437@1|root,COG4191@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H781@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_69710_1 1122194.AUHU01000016_gene1880 1.77e-16 87.4 COG3507@1|root,COG5297@1|root,COG3507@2|Bacteria,COG5297@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.4,3.2.1.78,3.2.1.91 ko:K01179,ko:K01218,ko:K19668 ko00051,ko00500,ko01100,ko02020,ko02024,map00051,map00500,map01100,map02020,map02024 - R01332,R02886,R06200,R11307,R11308 RC00467,RC00799 ko00000,ko00001,ko01000 - GH26,GH5,GH6,GH9 - CBM60,CBM_10,CBM_2,CBM_6,Cellulase,Glyco_hydro_11,Glyco_hydro_12,Glyco_hydro_26,Glyco_hydro_43,Glyco_hydro_45,Glyco_hydro_6,Malectin,PKD,Pec_lyase,RicinB_lectin_2 k59_16926_1 1541065.JRFE01000026_gene2161 6.15e-38 140.0 COG0530@1|root,COG0530@2|Bacteria,1G7C1@1117|Cyanobacteria 1117|Cyanobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_3923_1 674977.VMC_05770 1.98e-07 57.8 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_55858_1 330214.NIDE2247 5.85e-54 191.0 COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae 2|Bacteria L DNA-directed DNA polymerase dnaE-2 - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_134296_1 335543.Sfum_1917 3.65e-120 354.0 COG1077@1|root,COG1077@2|Bacteria,1R875@1224|Proteobacteria,42NJK@68525|delta/epsilon subdivisions,2WKDI@28221|Deltaproteobacteria,2MSIU@213462|Syntrophobacterales 28221|Deltaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_49949_1 1448139.AI20_14730 3.31e-14 74.7 29J9T@1|root,3067A@2|Bacteria,1RE8D@1224|Proteobacteria,1S4K6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2860) - - - - - - - - - - - - DUF2860 k59_101335_1 96561.Dole_3202 5.92e-99 297.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42NQF@68525|delta/epsilon subdivisions,2WKU3@28221|Deltaproteobacteria,2MIS8@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Iron-containing alcohol dehydrogenase - - 1.1.3.48 ko:K19714 - - R11394 RC03427 ko00000,ko01000,ko01005 - - - Fe-ADH k59_186562_1 264198.Reut_B3628 4.98e-20 99.4 COG2885@1|root,COG2885@2|Bacteria,1QUVV@1224|Proteobacteria,2WH8W@28216|Betaproteobacteria,1KG6M@119060|Burkholderiaceae 28216|Betaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_140368_1 56780.SYN_02626 4.92e-129 377.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_128451_1 1049564.TevJSym_ar00230 9.87e-157 454.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1J52S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_55976_1 1049564.TevJSym_aa01870 3.36e-62 207.0 COG1639@1|root,COG1639@2|Bacteria,1MXVB@1224|Proteobacteria,1RMNV@1236|Gammaproteobacteria,1J5JQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_4103_1 472759.Nhal_1425 9.89e-33 129.0 COG2199@1|root,COG4963@1|root,COG3706@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,1S66J@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Flp pilus assembly protein ATPase - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,CBP_BcsQ k59_166469_1 225937.HP15_321 3.62e-49 164.0 COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,46782@72275|Alteromonadaceae 1236|Gammaproteobacteria H COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK2 - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_108613_2 204536.SULAZ_0946 2.46e-26 104.0 COG0490@1|root,COG0490@2|Bacteria,2G45Z@200783|Aquificae 200783|Aquificae P TrkA-C domain protein - - - ko:K07228 - - - - ko00000 - - - TrkA_C k59_82642_1 1049564.TevJSym_ax00470 1.58e-104 312.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,1RSA6@1236|Gammaproteobacteria,1J9BK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pyridine nucleotide-disulphide oxidoreductase sqr - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_82642_2 1049564.TevJSym_ax00460 1.85e-29 106.0 2EPYJ@1|root,33HJ5@2|Bacteria,1NGGR@1224|Proteobacteria,1SI73@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_63335_1 396588.Tgr7_2492 0.000532 50.1 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWDP@135613|Chromatiales 135613|Chromatiales NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_4108_1 1047013.AQSP01000070_gene45 5.82e-54 175.0 COG1533@1|root,COG1533@2|Bacteria,2NPK6@2323|unclassified Bacteria 2|Bacteria L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_205444_1 335543.Sfum_2118 1.51e-109 332.0 COG0539@1|root,COG1093@1|root,COG0539@2|Bacteria,COG1093@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MR1P@213462|Syntrophobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_122177_1 933262.AXAM01000042_gene1834 2.67e-84 259.0 COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MID3@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - - - - - - - - - - - k59_186762_1 13689.BV96_00599 8.38e-10 59.3 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,2K0ZE@204457|Sphingomonadales 204457|Sphingomonadales S FldA protein - - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_186762_2 675812.VHA_002697 1.52e-64 219.0 COG3203@1|root,COG3203@2|Bacteria,1RE61@1224|Proteobacteria,1S5G1@1236|Gammaproteobacteria,1Y28K@135623|Vibrionales 135623|Vibrionales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_186762_3 1190606.AJYG01000069_gene690 3.2e-31 115.0 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,1SCQW@1236|Gammaproteobacteria,1XZ44@135623|Vibrionales 135623|Vibrionales P ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_37446_1 1121406.JAEX01000021_gene1455 2.9e-46 158.0 COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2M96M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 k59_24409_1 765910.MARPU_03820 1.3e-123 365.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_24409_2 765910.MARPU_03815 2.63e-12 63.5 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1WYR5@135613|Chromatiales 135613|Chromatiales J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_75598_2 754476.Q7A_2113 3.2e-36 140.0 COG2203@1|root,COG5001@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4609X@72273|Thiotrichales 72273|Thiotrichales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4 k59_101540_1 335543.Sfum_1180 1.82e-113 331.0 COG1908@1|root,COG1908@2|Bacteria,1RDMH@1224|Proteobacteria,42RX1@68525|delta/epsilon subdivisions,2WNT8@28221|Deltaproteobacteria 28221|Deltaproteobacteria CK Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD,HTH_5 k59_134501_1 420662.Mpe_A2763 2.38e-56 193.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KJ0P@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_50123_1 1121440.AUMA01000010_gene312 3.28e-51 164.0 COG0745@1|root,COG0745@2|Bacteria,1NBDV@1224|Proteobacteria,42UVC@68525|delta/epsilon subdivisions,2WQ45@28221|Deltaproteobacteria,2MBV0@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k59_50123_2 1121456.ATVA01000011_gene1357 1.14e-196 574.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_82651_1 1463920.JOGB01000036_gene6792 1.39e-47 172.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - BNR_2,CelD_N,Glyco_hydro_9,Laminin_G_3 k59_140576_2 96561.Dole_1520 4.33e-37 140.0 COG0745@1|root,COG2202@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MPJ3@213118|Desulfobacterales 28221|Deltaproteobacteria T PAS fold - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1,sCache_2 k59_101543_1 697282.Mettu_1061 7.63e-71 239.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales 135618|Methylococcales L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_96354_1 1521187.JPIM01000084_gene664 1.56e-34 137.0 COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,2G87Y@200795|Chloroflexi,376D4@32061|Chloroflexia 32061|Chloroflexia T diguanylate cyclase - - - - - - - - - - - - GAF_2,GGDEF,PAS_8 k59_122187_1 933262.AXAM01000039_gene1171 7.24e-52 180.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42NQY@68525|delta/epsilon subdivisions,2WISG@28221|Deltaproteobacteria,2MIXC@213118|Desulfobacterales 28221|Deltaproteobacteria HP MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_198606_1 1254432.SCE1572_24040 2.71e-05 53.9 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria,2YXD9@29|Myxococcales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg k59_37454_1 485913.Krac_9375 1.51e-48 171.0 COG3464@1|root,COG3464@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - UPF0236 k59_50126_1 1049564.TevJSym_af00550 4.97e-09 55.8 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1J4GH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iJN746.PP_4678,iLF82_1304.LF82_1103 IlvC,IlvN k59_114811_1 518766.Rmar_0015 2.44e-09 57.8 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,4NF8P@976|Bacteroidetes,1FIJX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_114811_2 1121451.DESAM_22222 1.73e-29 116.0 COG1541@1|root,COG1541@2|Bacteria,1N0HG@1224|Proteobacteria,42PT8@68525|delta/epsilon subdivisions,2WIY1@28221|Deltaproteobacteria,2M7S4@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_17156_1 1049564.TevJSym_as00020 4.41e-121 358.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_186780_1 96561.Dole_2348 1.35e-69 230.0 COG0507@1|root,COG1948@1|root,COG0507@2|Bacteria,COG1948@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MINC@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_63339_2 376686.Fjoh_4746 0.000154 48.1 COG1253@1|root,COG1253@2|Bacteria,4P5RF@976|Bacteroidetes,1IN7D@117743|Flavobacteriia,2NY91@237|Flavobacterium 976|Bacteroidetes S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_63339_3 913325.N799_12185 2.36e-43 147.0 COG3409@1|root,COG3409@2|Bacteria,1NJ0J@1224|Proteobacteria,1SQAT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall hydrolase - - - - - - - - - - - - - k59_63339_5 549.BW31_01500 3.49e-74 226.0 2AK67@1|root,31AW6@2|Bacteria,1RKU2@1224|Proteobacteria,1S6CF@1236|Gammaproteobacteria,3W1XG@53335|Pantoea 1236|Gammaproteobacteria S Type VI secretion system (T6SS), amidase effector protein 4 - - - - - - - - - - - - Tae4 k59_69938_1 177437.HRM2_10980 3.52e-70 228.0 COG5000@1|root,COG5000@2|Bacteria,1QWMS@1224|Proteobacteria,43BSR@68525|delta/epsilon subdivisions,2X73I@28221|Deltaproteobacteria,2MPJM@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_108644_1 314278.NB231_06211 4.66e-21 84.3 2EGMT@1|root,33ADY@2|Bacteria,1NH3I@1224|Proteobacteria,1SGAI@1236|Gammaproteobacteria,1WZTM@135613|Chromatiales 135613|Chromatiales S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N k59_44765_1 269799.Gmet_1393 1.96e-111 337.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_205456_2 1049564.TevJSym_ac00750 8.06e-164 465.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1J56V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliG GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_134515_2 1249627.D779_2748 3.62e-35 126.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1WZD5@135613|Chromatiales 135613|Chromatiales FG PFAM Histidine triad (HIT) protein - - - - - - - - - - - - HIT k59_63342_1 1049564.TevJSym_an00410 2.7e-197 563.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_153671_1 765914.ThisiDRAFT_2753 4.26e-67 216.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1WVUX@135613|Chromatiales 135613|Chromatiales M Lipid A biosynthesis lpxL - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_153671_2 1158756.AQXQ01000012_gene1847 8.7e-49 169.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales 135613|Chromatiales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_4126_1 765913.ThidrDRAFT_0611 5.34e-42 148.0 2CCJC@1|root,31PRJ@2|Bacteria,1R6D1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_4126_2 765913.ThidrDRAFT_0610 1.47e-147 420.0 COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,1RNF7@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Transport Permease Protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_4126_3 765913.ThidrDRAFT_0609 1.2e-96 290.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_4126_4 744980.TRICHSKD4_3854 2.3e-26 109.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat protein MA20_34510 - - - - - - - - - - - Cytochrom_D1,Lactonase k59_128681_1 879212.DespoDRAFT_00743 6.02e-18 87.0 COG1150@1|root,COG1150@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam k59_179890_1 561230.PC1_1872 2.54e-102 308.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1MSAN@122277|Pectobacterium 1236|Gammaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh k59_179890_2 1209072.ALBT01000035_gene1376 6.47e-77 238.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1FFYI@10|Cellvibrio 1236|Gammaproteobacteria J RNA pseudouridylate synthase rluE GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_179890_3 998674.ATTE01000001_gene1832 1.86e-164 471.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,45ZSN@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_205460_1 243164.DET1508 2.25e-39 132.0 COG2963@1|root,COG2963@2|Bacteria,2GAW0@200795|Chloroflexi,34DGC@301297|Dehalococcoidia 301297|Dehalococcoidia L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_4127_1 338963.Pcar_1385 1e-58 195.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_192625_1 1121441.AUCX01000009_gene2540 1.27e-38 140.0 COG3366@1|root,COG3366@2|Bacteria,1NEIQ@1224|Proteobacteria,42P9X@68525|delta/epsilon subdivisions,2WM1E@28221|Deltaproteobacteria,2M84E@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Nucleoside recognition - - - - - - - - - - - - - k59_56207_1 28229.ND2E_3900 3.48e-24 100.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,1SEDW@1236|Gammaproteobacteria,2Q71A@267889|Colwelliaceae 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_56207_2 501479.ACNW01000062_gene2740 1.05e-100 311.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_205696_1 1120963.KB894501_gene316 9.79e-27 103.0 COG2852@1|root,COG2852@2|Bacteria,1N7EJ@1224|Proteobacteria,1SF5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF559 k59_180092_2 1049564.TevJSym_br00050 1.56e-74 230.0 COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_198867_1 1121405.dsmv_1865 4.05e-38 143.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions,2WK5W@28221|Deltaproteobacteria,2MIDT@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Alpha amylase, catalytic treS - 2.4.1.4,2.4.1.7,3.2.1.1,5.4.99.16 ko:K00690,ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R00803,R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_91922_1 1304885.AUEY01000053_gene149 2.08e-22 100.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42SJA@68525|delta/epsilon subdivisions,2WPP4@28221|Deltaproteobacteria,2MK2H@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_27139_1 1307759.JOMJ01000004_gene2844 1.76e-179 529.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2M7Z1@213115|Desulfovibrionales 28221|Deltaproteobacteria V ABC transporter, transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_137196_1 521095.Apar_0878 1.6e-26 109.0 COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4CV18@84998|Coriobacteriia 84998|Coriobacteriia J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_130955_1 1304885.AUEY01000004_gene1001 5.88e-67 214.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2WIPW@28221|Deltaproteobacteria,2MI53@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Radical SAM domain protein yhcC-1 - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_990_1 1117647.M5M_14917 5.51e-23 105.0 COG2730@1|root,COG2730@2|Bacteria,1QU12@1224|Proteobacteria,1S0CV@1236|Gammaproteobacteria 1236|Gammaproteobacteria G endoglucanase engXCA - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,Cellulase k59_91924_1 886379.AEWI01000167_gene1009 6.46e-20 85.1 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - 2.1.1.72 ko:K07316,ko:K07495 - - - - ko00000,ko01000,ko02048 - - - DDE_5,DDE_Tnp_1 k59_92638_1 272134.KB731325_gene528 4.71e-33 131.0 COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,GGDEF,HATPase_c,HisKA,PAS_3,PAS_4,Pkinase,Response_reg,SpoIIE k59_72966_1 933262.AXAM01000031_gene3016 1.16e-47 155.0 2EDMA@1|root,337H4@2|Bacteria,1N9ES@1224|Proteobacteria,42VB1@68525|delta/epsilon subdivisions,2WRQZ@28221|Deltaproteobacteria,2MKGP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_60142_1 1249480.B649_11470 6.27e-57 190.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42NK6@68525|delta/epsilon subdivisions,2YMCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_157305_1 1410612.JNKO01000003_gene1597 2.87e-57 194.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,2PS5U@265975|Oribacterium 186801|Clostridia F CTP synthase N-terminus pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS01075 CTP_synth_N,GATase k59_112015_1 933262.AXAM01000021_gene464 9.61e-51 169.0 COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria,2MK70@213118|Desulfobacterales 28221|Deltaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_40835_1 1122137.AQXF01000005_gene1238 1.81e-99 299.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_8234_1 933262.AXAM01000139_gene294 6.6e-63 213.0 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_47109_1 1085623.GNIT_2963 1.92e-23 97.8 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,464S7@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2873 O-acetylhomoserine sulfhydrylase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - iJN746.PP_2528 Cys_Met_Meta_PP k59_79821_1 1320556.AVBP01000011_gene3420 3.55e-29 131.0 COG3447@1|root,COG5001@1|root,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,43RVC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_7,PAS_9,dCache_1 k59_72967_1 886293.Sinac_7422 0.000428 45.4 COG3344@1|root,COG3344@2|Bacteria,2IZGP@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_14409_4 882.DVU_1702 3.39e-90 273.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,42M5N@68525|delta/epsilon subdivisions,2X5TD@28221|Deltaproteobacteria,2MBXV@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_14409_5 637390.AFOH01000003_gene887 1.69e-20 92.4 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,2NC1J@225057|Acidithiobacillales 225057|Acidithiobacillales H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_131635_1 1125863.JAFN01000001_gene224 2e-80 261.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2WJJV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_27684_2 1049564.TevJSym_ai00030 2.69e-53 178.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria 1236|Gammaproteobacteria N ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_27684_3 1249627.D779_0903 1.1e-81 256.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1WY5A@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_137651_1 555778.Hneap_0971 4.07e-77 253.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6 ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_60149_1 1506994.JNLQ01000002_gene2255 2.63e-06 48.1 2EVBX@1|root,33NSE@2|Bacteria,1VKHC@1239|Firmicutes,24WCF@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_151000_1 933262.AXAM01000013_gene1318 1.27e-26 108.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_40843_1 880072.Desac_0544 6.34e-116 365.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MSJC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_189806_1 522772.Dacet_0951 3.34e-07 49.3 COG0724@1|root,COG0724@2|Bacteria,2GG4M@200930|Deferribacteres 200930|Deferribacteres S SMART RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_189806_2 1049564.TevJSym_at00570 1.65e-64 201.0 2CM34@1|root,32WDG@2|Bacteria,1N4BM@1224|Proteobacteria,1SAXK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2939) - - - - - - - - - - - - DUF2939 k59_189806_3 316057.RPD_1914 5.72e-05 52.4 COG2199@1|root,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,2U0TB@28211|Alphaproteobacteria,3JRD3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K21019 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GGDEF,MASE1,PAS,PAS_3,PAS_4 k59_189806_4 1049564.TevJSym_bb00330 0.0 1136.0 COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1J501@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Adenylate cyclase cyaA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 ko:K05851 ko00230,ko02026,ko05111,map00230,map02026,map05111 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365 Adenyl_cycl_N,Adenylate_cycl k59_189806_6 765911.Thivi_2388 5.3e-124 361.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1WVYQ@135613|Chromatiales 135613|Chromatiales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_189806_7 1049564.TevJSym_at00470 6.34e-89 269.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1J612@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yigA - - ko:K09921 - - - - ko00000 - - - DUF484 k59_60151_1 203119.Cthe_0917 9.21e-58 194.0 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,3WH6G@541000|Ruminococcaceae 186801|Clostridia J glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_8243_1 1049564.TevJSym_ag00240 2.62e-71 218.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1JAP2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q MlaD protein mlaD GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008289,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_8243_2 1049564.TevJSym_ag00230 4.24e-20 84.7 COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NTP binding protein (Contains STAS domain) yrbB - - ko:K07122 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - STAS_2 k59_8243_3 593907.Celgi_3197 2.94e-12 62.4 COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4F1DC@85016|Cellulomonadaceae 201174|Actinobacteria O Belongs to the thioredoxin family trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_163826_1 1502851.FG93_02933 1.72e-69 223.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,3JWF5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_27686_1 2340.JV46_19110 6.36e-40 139.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_27686_2 713587.THITH_02095 1.9e-70 228.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales 135613|Chromatiales C Prokaryotic cytochrome b561 - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_40844_2 926550.CLDAP_02040 6.12e-146 428.0 COG3385@1|root,COG3385@2|Bacteria,2G7UE@200795|Chloroflexi 200795|Chloroflexi L transposase activity - - - - - - - - - - - - - k59_202756_1 1121405.dsmv_2743 5.36e-121 357.0 COG0438@1|root,COG0438@2|Bacteria,1R4Q9@1224|Proteobacteria,42M0N@68525|delta/epsilon subdivisions,2WMAJ@28221|Deltaproteobacteria,2MI78@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_105377_1 765912.Thimo_0582 2.47e-117 342.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1WW6U@135613|Chromatiales 135613|Chromatiales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_112041_1 1123073.KB899241_gene3006 5.77e-62 202.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,1RP0Y@1236|Gammaproteobacteria,1X4JM@135614|Xanthomonadales 135614|Xanthomonadales L nadh pyrophosphatase nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_40848_1 439235.Dalk_3621 1.31e-111 335.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MI9Q@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_105381_1 177437.HRM2_02770 1.98e-89 275.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M11@68525|delta/epsilon subdivisions,2WK66@28221|Deltaproteobacteria,2MI46@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_60152_1 2340.JV46_25100 1.95e-35 121.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1J6RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_60152_2 395493.BegalDRAFT_2831 1.95e-52 170.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,46109@72273|Thiotrichales 72273|Thiotrichales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_98763_1 572477.Alvin_0284 4e-68 228.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1WWJW@135613|Chromatiales 135613|Chromatiales S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_98763_2 765913.ThidrDRAFT_1605 1.4e-94 291.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1WWQN@135613|Chromatiales 135613|Chromatiales H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_98763_3 1437824.BN940_02116 2.83e-20 94.7 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2VK1G@28216|Betaproteobacteria,3T43E@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33,6.3.4.15 ko:K01947,ko:K03525 ko00770,ko00780,ko01100,map00770,map00780,map01100 M00120 R01074,R02971,R03018,R04391,R05145 RC00002,RC00017,RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko00002,ko01000 - - - BPL_C,BPL_LplA_LipB,Pan_kinase k59_112042_1 429009.Adeg_1885 4.96e-23 97.8 COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S ferredoxin, iron-sulfur binding - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_72983_1 1408473.JHXO01000008_gene2597 2.15e-79 249.0 COG1708@1|root,COG2250@1|root,COG1708@2|Bacteria,COG2250@2|Bacteria,4NNCW@976|Bacteroidetes,2FRJR@200643|Bacteroidia 976|Bacteroidetes S HEPN domain - - - - - - - - - - - - HEPN k59_72983_2 998674.ATTE01000001_gene3340 1.79e-40 137.0 COG1848@1|root,COG1848@2|Bacteria,1QZUI@1224|Proteobacteria,1SAA0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PIN domain - - - - - - - - - - - - PIN_3 k59_21351_1 96561.Dole_2133 3.67e-85 265.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MIA5@213118|Desulfobacterales 28221|Deltaproteobacteria L AAA ATPase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_27697_1 335543.Sfum_2348 1.86e-79 248.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_98764_1 177439.DP0244 1.6e-43 146.0 29FA5@1|root,3027T@2|Bacteria,1REEQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_8258_1 1026882.MAMP_00725 1.5e-76 244.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_92680_1 945713.IALB_0171 1.1e-55 194.0 COG0474@1|root,COG0474@2|Bacteria 2|Bacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.2,3.6.3.6 ko:K01531,ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3,3.A.3.4 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_157328_1 1049564.TevJSym_ag00340 3.09e-153 452.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_183516_1 1249627.D779_0932 2.51e-91 300.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_183516_2 765913.ThidrDRAFT_1717 4.42e-76 236.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales 135613|Chromatiales I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_66472_1 880072.Desac_0836 1.36e-46 167.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_21355_1 768671.ThimaDRAFT_0112 3.13e-68 224.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_21355_2 395493.BegalDRAFT_0520 3.65e-27 112.0 COG5002@1|root,COG5002@2|Bacteria,1QTSA@1224|Proteobacteria,1T1PH@1236|Gammaproteobacteria,463U3@72273|Thiotrichales 72273|Thiotrichales T Two-component sensor kinase N-terminal - - - - - - - - - - - - 2CSK_N,HATPase_c,HisKA k59_92685_1 326298.Suden_0279 1.31e-55 193.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,42PHJ@68525|delta/epsilon subdivisions,2YNKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_98767_2 1123253.AUBD01000001_gene1665 3.08e-06 50.1 COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria,1X7P5@135614|Xanthomonadales 135614|Xanthomonadales C cytochrome - - - - - - - - - - - - Cytochrom_C k59_53546_1 1123261.AXDW01000004_gene2919 1.24e-33 127.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1X3DC@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the reversible hydration of fumarate to (S)- malate fumB - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_79851_3 745411.B3C1_11784 1.07e-06 48.1 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1J6NZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Recycling of diacylglycerol produced during the turnover of membrane phospholipid dgkA - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_1551_1 1128421.JAGA01000003_gene3683 2.68e-202 605.0 COG5297@1|root,COG5297@2|Bacteria,2NQDB@2323|unclassified Bacteria 2|Bacteria G CBD_II - - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_10,CBM_2,Glyco_hydro_6,PKD k59_202776_1 706587.Desti_3296 3.04e-15 76.6 COG1032@1|root,COG1032@2|Bacteria,1MUMS@1224|Proteobacteria,42QFG@68525|delta/epsilon subdivisions,2WK91@28221|Deltaproteobacteria 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_60340_1 497321.C664_00590 7.01e-22 94.7 2BJZ8@1|root,32EC2@2|Bacteria,1RF67@1224|Proteobacteria,2VUGD@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2380) - - - - - - - - - - - - DUF3280 k59_60340_2 1026882.MAMP_01526 5.77e-83 260.0 COG1665@1|root,COG1665@2|Bacteria,1RCBC@1224|Proteobacteria,1S28R@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - ko:K09717 - - - - ko00000 - - - NTP_transf_2 k59_139475_1 1049564.TevJSym_ac01950 2.54e-145 417.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1J4M5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_159320_1 709032.Sulku_1776 1.3e-45 179.0 COG0823@1|root,COG0823@2|Bacteria,1QXUF@1224|Proteobacteria,43234@68525|delta/epsilon subdivisions,2YTHN@29547|Epsilonproteobacteria 1224|Proteobacteria U Domain of unknown function (DUF4214) - - - - - - - - - - - - Cadherin,DUF4214,DUF5122,HYR,VCBS k59_55123_6 344747.PM8797T_25196 5.97e-136 390.0 COG0024@1|root,COG0024@2|Bacteria,2J1QY@203682|Planctomycetes 203682|Planctomycetes J Methionine aminopeptidase - - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_107468_1 476272.RUMHYD_02867 5.28e-11 67.4 COG3292@1|root,COG3292@2|Bacteria,1UICX@1239|Firmicutes,24ABD@186801|Clostridia,3Y1BC@572511|Blautia 186801|Clostridia T Psort location Extracellular, score - - - - - - - - - - - - Big_3_3 k59_197704_2 1188256.BASI01000007_gene2293 0.000629 45.8 COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,3FCYQ@34008|Rhodovulum 28211|Alphaproteobacteria M Transglycosylase SLT domain mltB - - ko:K00786,ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - PG_binding_1,SLT_2 k59_29543_2 1049564.TevJSym_af00320 6.43e-46 154.0 COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,1S7QS@1236|Gammaproteobacteria,1JA2I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_165554_1 344747.PM8797T_28014 1.52e-47 158.0 2F94S@1|root,341GA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_62305_1 485915.Dret_0751 2.13e-59 198.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2M838@213115|Desulfovibrionales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_3167_1 1121405.dsmv_2653 5.63e-103 306.0 COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,42RGI@68525|delta/epsilon subdivisions,2WNGP@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_28,HTH_33 k59_68704_1 1121405.dsmv_0315 2.66e-208 583.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MIY0@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM sodium ion-translocating decarboxylase, beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_127587_3 1411123.JQNH01000001_gene42 2.93e-46 166.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria HP TIGRFAM molybdenum cofactor synthesis domain MA20_10225 - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_152666_2 36630.CADNFIAP00003350 1.86e-11 64.3 COG2084@1|root,KOG0409@2759|Eukaryota,3ANX0@33154|Opisthokonta,3PEMC@4751|Fungi,3QY7Y@4890|Ascomycota,20KF5@147545|Eurotiomycetes,3SC82@5042|Eurotiales 4751|Fungi E NADP oxidoreductase coenzyme F420-dependent - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_2 k59_191682_2 998674.ATTE01000001_gene2811 1.16e-22 95.1 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,461G2@72273|Thiotrichales 72273|Thiotrichales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_68708_1 314278.NB231_09098 2.6e-41 148.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_165737_3 572477.Alvin_0283 2.28e-41 137.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales 135613|Chromatiales S RNA-binding protein - - - - - - - - - - - - RRM_1 k59_165737_4 1996.JOFO01000024_gene4245 1.35e-06 56.6 COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4EGNX@85012|Streptosporangiales 201174|Actinobacteria L helicase superfamily c-terminal domain rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_152883_1 555088.DealDRAFT_0080 5.38e-15 82.0 COG0675@1|root,COG0675@2|Bacteria,1TRNY@1239|Firmicutes,247T1@186801|Clostridia 186801|Clostridia L Transposase, IS605 OrfB family - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k59_107684_1 1049564.TevJSym_ch00070 9.6e-05 45.1 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1SZ5G@1236|Gammaproteobacteria,1JBU3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2,SpoIIE k59_107684_3 243233.MCA3058 1.52e-29 106.0 COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1XFQV@135618|Methylococcales 135618|Methylococcales S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_16334_1 593750.Metfor_2804 8.55e-09 62.4 COG0642@1|root,arCOG02350@1|root,arCOG02353@1|root,arCOG06940@1|root,arCOG02350@2157|Archaea,arCOG02353@2157|Archaea,arCOG06193@2157|Archaea,arCOG06940@2157|Archaea 2157|Archaea T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_113977_2 1049564.TevJSym_aa00330 2.12e-69 224.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1J4FQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP major facilitator superfamily yajR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr k59_133730_1 525897.Dbac_3209 8.24e-74 247.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales 28221|Deltaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_43707_1 1229205.BUPH_04912 2.13e-24 94.7 2E68H@1|root,330WQ@2|Bacteria,1ND48@1224|Proteobacteria,2W3M8@28216|Betaproteobacteria,1KAUX@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_43707_2 1198232.CYCME_3051 1.86e-20 89.7 2DBDN@1|root,2Z8N5@2|Bacteria,1R9H1@1224|Proteobacteria,1SM4V@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_197897_1 1191523.MROS_1569 3.31e-58 201.0 COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_152889_1 1049564.TevJSym_aj00810 1.19e-73 243.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1J907@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain ttrA - 1.8.5.5,1.8.5.6 ko:K08352,ko:K08357,ko:K21307 ko00920,ko01100,ko01120,ko02020,map00920,map01100,map01120,map02020 - R10149,R10150,R11487 RC00168,RC02823,RC03109 ko00000,ko00001,ko01000,ko02000 5.A.3.10,5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_152889_2 396588.Tgr7_0339 6.1e-37 130.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1WWTE@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S - - - ko:K00184,ko:K21308 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 5.A.3 - - Fer4_11,Fer4_4,Fer4_7 k59_133733_1 335543.Sfum_3063 9.84e-82 255.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MQ40@213462|Syntrophobacterales 28221|Deltaproteobacteria M PDZ domain (Also known as DHR or GLGF) ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_49324_1 338966.Ppro_1387 5.9e-113 344.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2WJPB@28221|Deltaproteobacteria,43T5J@69541|Desulfuromonadales 28221|Deltaproteobacteria H Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_95464_1 1211579.PP4_22440 1.56e-11 68.9 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RQ6B@1236|Gammaproteobacteria,1YVBW@136845|Pseudomonas putida group 1236|Gammaproteobacteria MU RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_185880_1 313596.RB2501_12562 1.43e-28 118.0 COG0457@1|root,COG0457@2|Bacteria,4NH87@976|Bacteroidetes,1HZMD@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_16337_1 555778.Hneap_0560 1.06e-134 392.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WY32@135613|Chromatiales 135613|Chromatiales P SMART Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_179133_1 1288963.ADIS_2558 2.53e-19 91.3 COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes,47KTS@768503|Cytophagia 976|Bacteroidetes O Zn-dependent protease with chaperone function - - 3.4.24.84 ko:K03799,ko:K06013 ko00900,ko01130,map00900,map01130 M00743 R09845 RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_43717_1 207954.MED92_06473 6.16e-59 205.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XIWS@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_139665_1 933262.AXAM01000023_gene660 3.7e-105 307.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42QSV@68525|delta/epsilon subdivisions,2WMZ5@28221|Deltaproteobacteria,2MI25@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM Sua5 YciO YrdC YwlC family protein yrdC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_185881_1 1249627.D779_1785 3.64e-131 411.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales 135613|Chromatiales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_159573_1 555778.Hneap_0793 2.99e-87 263.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,1RR9A@1236|Gammaproteobacteria,1WZVC@135613|Chromatiales 135613|Chromatiales S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_10532_1 1121405.dsmv_3142 1.94e-52 174.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MI18@213118|Desulfobacterales 28221|Deltaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_10532_2 1499967.BAYZ01000143_gene6132 1.09e-15 73.2 COG0764@1|root,COG0764@2|Bacteria 2|Bacteria I 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC k59_29759_2 1049564.TevJSym_ak00400 3.63e-101 306.0 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1J6CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_29759_4 1049564.TevJSym_ak00380 1.85e-296 824.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_23539_1 1049564.TevJSym_au00430 2.11e-79 256.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1J524@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_133736_1 335543.Sfum_0185 1.65e-96 295.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2MRVG@213462|Syntrophobacterales 28221|Deltaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_191894_1 1230341.MJ3_01817 7.34e-18 92.4 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,4HB35@91061|Bacilli 91061|Bacilli L Transposase IS116 IS110 IS902 - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_3349_2 1101195.Meth11DRAFT_1323 7.23e-23 92.8 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2VSJY@28216|Betaproteobacteria,2KMRX@206350|Nitrosomonadales 206350|Nitrosomonadales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_107703_1 1049564.TevJSym_aw00530 1.56e-12 66.2 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1J68A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_107703_2 1049564.TevJSym_aw00520 3.6e-116 345.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1J4V3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_49332_1 765913.ThidrDRAFT_0566 1.11e-75 236.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1S30B@1236|Gammaproteobacteria,1X0PA@135613|Chromatiales 135613|Chromatiales HJ Belongs to the RimK family - - - - - - - - - - - - RimK k59_49332_2 754476.Q7A_44 1.45e-17 81.3 COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,1S1PA@1236|Gammaproteobacteria,46221@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT mch - 3.5.4.27 ko:K01499 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03464 RC01870 ko00000,ko00001,ko00002,ko01000 - - - MCH k59_204731_1 203122.Sde_3420 1.21e-248 704.0 COG2730@1|root,COG5297@1|root,COG2730@2|Bacteria,COG5297@2|Bacteria,1PY25@1224|Proteobacteria,1SYWJ@1236|Gammaproteobacteria,4666R@72275|Alteromonadaceae 1236|Gammaproteobacteria G CBD_II - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_10,CBM_2,CBM_5_12_2,Cellulase,Glyco_hydro_11 k59_197904_1 485913.Krac_9327 2.32e-84 263.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_127829_1 1499967.BAYZ01000039_gene2238 8.65e-96 289.0 COG2070@1|root,COG2070@2|Bacteria,2NNYB@2323|unclassified Bacteria 2|Bacteria S Nitronate monooxygenase npd - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_16343_1 604331.AUHY01000088_gene1435 8.99e-10 59.3 COG1131@1|root,COG1131@2|Bacteria,1WI8V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V ABC-type multidrug transport system ATPase component - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_159581_1 383372.Rcas_0194 2.56e-40 148.0 COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi 200795|Chloroflexi L sptr a7nhu5 - - - - - - - - - - - - DDE_5 k59_204733_2 104623.Ser39006_02891 3.57e-44 166.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria,4058H@613|Serratia 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_172314_1 1049564.TevJSym_ai00310 8.2e-145 415.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1J5E9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02464,ko:K02654 ko03070,map03070 M00331 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15,3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_68944_1 335543.Sfum_0109 3.67e-50 169.0 COG2454@1|root,COG2454@2|Bacteria,1N6TV@1224|Proteobacteria,42VER@68525|delta/epsilon subdivisions,2WRI3@28221|Deltaproteobacteria,2MS7Y@213462|Syntrophobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF434) - - - - - - - - - - - - DUF434 k59_179136_3 545276.KB898725_gene687 4.53e-137 400.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_174576_1 439235.Dalk_4458 1.42e-63 237.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2204@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2204@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria,2MPM5@213118|Desulfobacterales 68525|delta/epsilon subdivisions T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_8,PAS_9,Response_reg k59_207018_7 98439.AJLL01000014_gene1638 8.97e-91 275.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_207018_8 870187.Thini_3587 1.96e-186 538.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,462AE@72273|Thiotrichales 72273|Thiotrichales L PFAM Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_168398_2 765910.MARPU_07620 1.38e-17 75.5 COG3242@1|root,COG3242@2|Bacteria,1PU4I@1224|Proteobacteria,1TK3B@1236|Gammaproteobacteria,1WZE8@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2065) - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_168398_4 1049564.TevJSym_bl00180 3.26e-155 449.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1J4H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_200420_2 1232437.KL662048_gene5095 1.13e-61 190.0 COG0599@1|root,COG0599@2|Bacteria,1NBJR@1224|Proteobacteria,42SYS@68525|delta/epsilon subdivisions,2WPQD@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_200420_3 59919.PMM0638 0.00043 45.8 COG0535@1|root,COG0535@2|Bacteria,1G18X@1117|Cyanobacteria,1MKFR@1212|Prochloraceae 1117|Cyanobacteria S Alternative locus ID - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_200423_1 485918.Cpin_4134 9.2e-09 56.6 COG2005@1|root,COG2005@2|Bacteria,4NUSR@976|Bacteroidetes,1ITYZ@117747|Sphingobacteriia 976|Bacteroidetes K PFAM Bacterial regulatory helix-turn-helix protein, lysR family - - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1 k59_200423_2 255470.cbdbA1032 2.21e-11 64.3 COG0745@1|root,COG0745@2|Bacteria,2G6JT@200795|Chloroflexi,34CJN@301297|Dehalococcoidia 301297|Dehalococcoidia K Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_57779_3 667121.ET1_07_00430 3.01e-99 303.0 2F1K9@1|root,33UKP@2|Bacteria,1NVFP@1224|Proteobacteria,1SPTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_57779_5 1286106.MPL1_03970 4.37e-31 112.0 COG3668@1|root,COG3668@2|Bacteria,1N75M@1224|Proteobacteria,1S67C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the RelE toxin family - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_57779_6 1121481.AUAS01000011_gene5081 7.64e-21 85.1 COG3609@1|root,COG3609@2|Bacteria,4NSHD@976|Bacteroidetes,47R4Z@768503|Cytophagia 976|Bacteroidetes K addiction module antidote protein, CC2985 family - - - ko:K07746 - - - - ko00000,ko02048 - - - ParD_antitoxin k59_168411_1 502025.Hoch_0005 1.37e-71 227.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2YU4F@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_174596_1 118168.MC7420_1869 2.22e-59 193.0 COG0714@1|root,COG0714@2|Bacteria,1G1UF@1117|Cyanobacteria,1H70F@1150|Oscillatoriales 1117|Cyanobacteria O PFAM ATPase family associated with various cellular activities (AAA) morR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_5812_1 1348657.M622_08280 1.54e-77 246.0 2C2F5@1|root,32WND@2|Bacteria,1N9J7@1224|Proteobacteria,2W66E@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_149051_1 1121396.KB893001_gene3951 1.84e-31 129.0 COG2067@1|root,COG2067@2|Bacteria,1NHG3@1224|Proteobacteria 1224|Proteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_77573_1 1415778.JQMM01000001_gene1204 2.64e-71 218.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1J5PI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_221_1 1121405.dsmv_0379 4.7e-82 261.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,TrkA_C,Voltage_CLC k59_221_2 933262.AXAM01000027_gene2086 1.2e-11 63.2 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2MJMQ@213118|Desulfobacterales 28221|Deltaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_188153_1 765913.ThidrDRAFT_3829 2.35e-44 151.0 COG4968@1|root,COG4968@2|Bacteria,1PSJQ@1224|Proteobacteria,1RVXT@1236|Gammaproteobacteria,1X1JD@135613|Chromatiales 135613|Chromatiales U Prokaryotic N-terminal methylation motif - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - N_methyl k59_188153_2 1042209.HK44_023805 2.44e-107 362.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YR88@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T CHASE - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - CHASE,EAL,GGDEF,PAS,PAS_4,PAS_9 k59_188153_3 1049564.TevJSym_aa02050 1.08e-78 242.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1J669@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG1214 Inactive homolog of metal-dependent proteases yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_194567_1 1121405.dsmv_0204 8.41e-101 301.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2MID1@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM PhoH family protein phoH2 - - ko:K06217 - - - - ko00000 - - - PhoH k59_194567_2 933262.AXAM01000002_gene508 7.19e-22 96.3 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales 28221|Deltaproteobacteria S metal-dependent phosphohydrolase 7TM intracellular region - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_32591_2 589865.DaAHT2_2039 1.27e-23 98.2 COG0637@1|root,COG0637@2|Bacteria,1QW0J@1224|Proteobacteria,43BQD@68525|delta/epsilon subdivisions,2X71F@28221|Deltaproteobacteria,2MPIT@213118|Desulfobacterales 28221|Deltaproteobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_39050_1 765912.Thimo_0705 3.92e-127 370.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_13123_1 439235.Dalk_5090 3.47e-99 318.0 COG1018@1|root,COG1148@1|root,COG1018@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_227_1 96561.Dole_0848 8.88e-91 281.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Starch synthase catalytic - - 2.4.1.21,3.2.1.1 ko:K00703,ko:K01176 ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973 M00565 R02108,R02112,R02421,R11262 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GH13,GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_32593_1 631362.Thi970DRAFT_04898 1.39e-133 409.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales 135613|Chromatiales U Hydrophobe Amphiphile Efflux-1 (HAE1) - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_64982_1 1301098.PKB_4381 3.89e-76 241.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_136306_1 28229.ND2E_3857 9.82e-40 166.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,CZB,DUF4118,EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Protoglobin k59_32596_1 335543.Sfum_1328 5.84e-61 201.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,43A0M@68525|delta/epsilon subdivisions,2X9UN@28221|Deltaproteobacteria,2MS7U@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red k59_181689_2 644282.Deba_0655 2.9e-07 54.3 COG3103@1|root,COG4913@1|root,COG3103@2|Bacteria,COG4913@2|Bacteria,1R1CB@1224|Proteobacteria,43D8S@68525|delta/epsilon subdivisions,2X8FE@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial SH3 domain - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_90993_1 1049564.TevJSym_bq00030 7.85e-36 133.0 COG1385@1|root,COG4660@1|root,COG1385@2|Bacteria,COG4660@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1J5UQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_19647_1 595537.Varpa_4916 0.000905 46.6 COG4970@1|root,COG4970@2|Bacteria,1NA9B@1224|Proteobacteria,2VV1S@28216|Betaproteobacteria,4AJN6@80864|Comamonadaceae 28216|Betaproteobacteria NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_26165_1 614083.AWQR01000009_gene588 3.91e-70 228.0 COG2203@1|root,COG2203@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,4ACU3@80864|Comamonadaceae 28216|Betaproteobacteria T Pfam:Pyridox_oxidase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF_2,Putative_PNPOx k59_235_1 395963.Bind_0317 1.14e-11 63.2 COG3177@1|root,COG3177@2|Bacteria,1NB0K@1224|Proteobacteria,2TTTS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Filamentation induced by cAMP protein fic - - - - - - - - - - - - Fic k59_6661_1 1274.HX89_12410 4.85e-05 46.6 COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,1ZVG1@145357|Dermacoccaceae 201174|Actinobacteria BQ Histone deacetylase domain acuC - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_6661_2 1304883.KI912532_gene988 2.44e-26 105.0 COG1010@1|root,COG1010@2|Bacteria,1MU79@1224|Proteobacteria,2VIG5@28216|Betaproteobacteria,2KUEX@206389|Rhodocyclales 206389|Rhodocyclales H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_58569_1 335543.Sfum_0455 8.44e-73 220.0 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,2MRYD@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase mceE - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_149280_1 1121405.dsmv_1068 8.97e-85 256.0 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria,2MJA7@213118|Desulfobacterales 28221|Deltaproteobacteria H PBP superfamily domain tupA - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_78060_1 1238182.C882_0562 1.93e-64 224.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2JQ7S@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_129842_1 1049564.TevJSym_aj00790 3.77e-51 171.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1RS3Q@1236|Gammaproteobacteria,1JB7K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DMSO reductase anchor subunit (DmsC) dmsC - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC k59_155761_1 546268.NEISUBOT_03712 3.35e-125 362.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,2KPIK@206351|Neisseriales 206351|Neisseriales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_155761_2 270374.MELB17_19199 4.84e-58 189.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_65004_1 1121405.dsmv_1078 3.41e-50 179.0 COG0243@1|root,COG0243@2|Bacteria,1R4RR@1224|Proteobacteria,42PA5@68525|delta/epsilon subdivisions,2WM0K@28221|Deltaproteobacteria,2MI3Z@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family qrcB - - ko:K08357 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_32607_2 768671.ThimaDRAFT_3125 1e-66 216.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WX0J@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_6679_1 880072.Desac_1764 2.31e-30 116.0 COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,42U66@68525|delta/epsilon subdivisions,2X374@28221|Deltaproteobacteria,2MS8Z@213462|Syntrophobacterales 28221|Deltaproteobacteria T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_78064_2 1499967.BAYZ01000080_gene894 8.03e-23 90.5 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_91002_1 335543.Sfum_3874 8.55e-59 199.0 COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MQBZ@213462|Syntrophobacterales 28221|Deltaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,cNMP_binding k59_65012_1 1122201.AUAZ01000003_gene1927 1.81e-54 184.0 COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,1T1FN@1236|Gammaproteobacteria,464T3@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG0477 Permeases of the major facilitator superfamily ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_194573_1 1049564.TevJSym_ab01930 2.48e-53 189.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1J4N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_168712_1 879212.DespoDRAFT_00640 5.57e-31 113.0 2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria,2MMAB@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_123385_1 663321.REG_0548 3.61e-273 791.0 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,1RPPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase group 1 wbdA1 - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_32611_1 1265505.ATUG01000001_gene4235 2.32e-61 204.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42N7Y@68525|delta/epsilon subdivisions,2WIX7@28221|Deltaproteobacteria,2MMU7@213118|Desulfobacterales 28221|Deltaproteobacteria KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_8,Sigma54_activat k59_103900_1 523791.Kkor_0311 1.51e-83 270.0 COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,1XJ1A@135619|Oceanospirillales 135619|Oceanospirillales E Thermolysin metallopeptidase, catalytic domain - - 3.4.24.25 ko:K08604 ko05110,ko05111,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002 - - - FTP,PPC,P_proprotein,PepSY,Peptidase_M4,Peptidase_M4_C k59_103900_2 722419.PH505_ay00080 8.44e-62 209.0 COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,2Q0GV@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E COG3227 Zinc metalloprotease (elastase) - - 3.4.24.25 ko:K08604 ko05110,ko05111,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002 - - - FTP,PPC,PepSY,Peptidase_M4,Peptidase_M4_C k59_84433_1 1382306.JNIM01000001_gene2696 3.4e-27 113.0 COG1488@1|root,COG1488@2|Bacteria,2G70D@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - - k59_97462_1 667014.Thein_1313 5.99e-42 152.0 COG0859@1|root,COG0859@2|Bacteria,2GGZ0@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_13153_1 1049564.TevJSym_bu00040 6.55e-302 863.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_184752_1 1454004.AW11_03317 2.41e-87 280.0 COG1404@1|root,COG1404@2|Bacteria,1ND93@1224|Proteobacteria,2VKTR@28216|Betaproteobacteria 28216|Betaproteobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_164842_1 1123376.AUIU01000015_gene450 4.08e-21 92.0 COG1399@1|root,COG1399@2|Bacteria,3J0UQ@40117|Nitrospirae 40117|Nitrospirae S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_132855_1 999611.KI421504_gene3168 0.000371 47.8 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,280ZF@191028|Leisingera 28211|Alphaproteobacteria O ClpX C4-type zinc finger clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_138740_1 1042377.AFPJ01000028_gene2144 0.000991 45.4 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,465D4@72275|Alteromonadaceae 1236|Gammaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_138740_2 1396858.Q666_11625 0.0 953.0 COG1196@1|root,COG3593@1|root,COG1196@2|Bacteria,COG3593@2|Bacteria,1MXAH@1224|Proteobacteria,1RWJE@1236|Gammaproteobacteria,46AGW@72275|Alteromonadaceae 1236|Gammaproteobacteria L AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 k59_138740_3 402626.Rpic_3174 1.85e-21 92.8 COG0210@1|root,COG0210@2|Bacteria,1NBQK@1224|Proteobacteria,2VHV5@28216|Betaproteobacteria,1K78E@119060|Burkholderiaceae 28216|Betaproteobacteria L UvrD-like helicase C-terminal domain - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_196949_1 335543.Sfum_1062 1.15e-94 282.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WK7S@28221|Deltaproteobacteria,2MQG1@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_158478_1 1167006.UWK_02735 2.45e-68 218.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2MIGE@213118|Desulfobacterales 28221|Deltaproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3391 Radical_SAM k59_106573_1 1122222.AXWR01000001_gene1866 3.44e-60 202.0 COG0123@1|root,COG0123@2|Bacteria,1WIFA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus BQ including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_132857_1 1244869.H261_12381 2.01e-91 281.0 COG0407@1|root,COG0407@2|Bacteria,1R9IN@1224|Proteobacteria 1224|Proteobacteria H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_191024_1 644282.Deba_1144 2.02e-37 130.0 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,42SXV@68525|delta/epsilon subdivisions,2WPSN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF1178) - - - - - - - - - - - - DUF1178 k59_22568_1 933262.AXAM01000043_gene1196 4.34e-106 312.0 COG1830@1|root,COG1830@2|Bacteria,1MWJW@1224|Proteobacteria,42NP9@68525|delta/epsilon subdivisions,2WIP9@28221|Deltaproteobacteria,2MIJY@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids aroA' - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_126582_1 706587.Desti_4800 1.54e-23 100.0 COG2202@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MSKU@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1,sCache_2 k59_48287_1 891968.Anamo_1973 1.53e-38 144.0 COG3328@1|root,COG3328@2|Bacteria,3TAQX@508458|Synergistetes 508458|Synergistetes L PFAM Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_106574_1 453591.Igni_0578 0.000219 47.0 COG0456@1|root,arCOG00833@2157|Archaea,2XR31@28889|Crenarchaeota 28889|Crenarchaeota K TIGRFAM ribosomal-protein-alanine acetyltransferase - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_54520_3 1168065.DOK_02291 4.94e-129 372.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,1JAW0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_68045_1 1121422.AUMW01000002_gene2164 1.59e-05 47.4 COG0839@1|root,COG0839@2|Bacteria,1VAQI@1239|Firmicutes,24NAC@186801|Clostridia,2626F@186807|Peptococcaceae 186801|Clostridia C Belongs to the complex I subunit 6 family ndhG - 1.6.5.3 ko:K00339,ko:K05578 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_68045_2 795797.C497_10988 4.47e-16 75.1 COG0713@1|root,arCOG03073@2157|Archaea,2XXW4@28890|Euryarchaeota,23W1K@183963|Halobacteria 183963|Halobacteria C NADH ubiquinone oxidoreductase subunit 11 or 4L (Chain K) nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_158721_1 88036.EFJ14476 8.95e-51 176.0 COG1806@1|root,2QQ1R@2759|Eukaryota,37NRA@33090|Viridiplantae,3GFS0@35493|Streptophyta 35493|Streptophyta S pyruvate, phosphate dikinase regulatory protein - GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.7.11.32,2.7.4.27 ko:K20115 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_54726_1 1008459.TASI_1294 3.55e-16 84.3 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,3T227@506|Alcaligenaceae 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_2724_1 477974.Daud_1279 5.17e-115 339.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260XK@186807|Peptococcaceae 186801|Clostridia CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate - - 1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 ko:K00052,ko:K07246 ko00290,ko00630,ko00650,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00630,map00650,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00215,R00994,R01751,R02545,R04426,R06180,R10052 RC00084,RC00105,RC00417,RC00594,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_42588_1 118168.MC7420_1035 7.46e-26 115.0 COG0642@1|root,COG2202@1|root,COG3605@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3605@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H71H@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_106833_1 697282.Mettu_2837 2.24e-43 149.0 COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,1S2CW@1236|Gammaproteobacteria,1XEB6@135618|Methylococcales 135618|Methylococcales S Thioesterase domain - - - - - - - - - - - - Abhydrolase_1 k59_191195_1 1144275.COCOR_02281 5.85e-187 604.0 COG1061@1|root,COG1061@2|Bacteria 2|Bacteria L Type III restriction enzyme res subunit - - - - - - - - - - - - DUF3854,DUF4379,Helicase_C,Methyltransf_8,ResIII,SNF2_N k59_191195_2 640081.Dsui_3277 2.83e-107 320.0 2E1SQ@1|root,32X2J@2|Bacteria,1N5BT@1224|Proteobacteria,2W260@28216|Betaproteobacteria 28216|Betaproteobacteria S T5orf172 domain - - - - - - - - - - - - T5orf172 k59_28962_1 1123371.ATXH01000027_gene155 7.48e-13 72.8 COG1381@1|root,COG1381@2|Bacteria,2GHRN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_158728_1 1379281.AVAG01000032_gene119 2.23e-22 96.7 COG0438@1|root,COG0438@2|Bacteria,1R8YI@1224|Proteobacteria,42N8I@68525|delta/epsilon subdivisions,2WIYJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_171798_1 1229205.BUPH_05533 1.74e-09 57.8 COG2963@1|root,COG2963@2|Bacteria,1N37Z@1224|Proteobacteria,2VUMC@28216|Betaproteobacteria,1K8VK@119060|Burkholderiaceae 28216|Betaproteobacteria L Elements of external origin - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_171798_2 765913.ThidrDRAFT_0640 4.7e-87 267.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales 135613|Chromatiales L PFAM integrase - - - - - - - - - - - - HTH_21,rve k59_133031_1 177439.DP1462 8.13e-10 65.1 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJ3M@28221|Deltaproteobacteria,2MJD4@213118|Desulfobacterales 28221|Deltaproteobacteria NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_138915_1 335543.Sfum_0020 4.72e-87 280.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_204022_1 1049564.TevJSym_ap00560 1.55e-62 214.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1J62R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_204022_2 1049564.TevJSym_ap00550 3.76e-47 160.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1J5UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_15564_2 1049564.TevJSym_aa00960 1.12e-78 272.0 COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_185004_2 404589.Anae109_1288 2.18e-76 232.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2Z08H@29|Myxococcales 28221|Deltaproteobacteria C Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_197185_1 207559.Dde_1895 4.17e-07 53.1 2D5BE@1|root,32TIP@2|Bacteria,1N5ZZ@1224|Proteobacteria,42TZP@68525|delta/epsilon subdivisions,2WQ1J@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_94485_1 653733.Selin_2484 8.75e-93 288.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_22760_1 395964.KE386496_gene421 4.38e-23 104.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3N9Y5@45404|Beijerinckiaceae 28211|Alphaproteobacteria T Integral membrane sensor signal transduction histidine kinase ragB - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_81135_1 485913.Krac_0317 3e-09 60.5 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_61652_1 768671.ThimaDRAFT_3831 2.47e-15 74.3 COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria,1WXWE@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_61652_2 1049564.TevJSym_br00040 2.19e-179 506.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1J55P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfD2 - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_68059_1 1049564.TevJSym_ax00230 3.29e-110 329.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1J555@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_133033_1 552811.Dehly_1284 1.11e-57 199.0 COG0209@1|root,COG0209@2|Bacteria,2G5PW@200795|Chloroflexi,34CT1@301297|Dehalococcoidia 301297|Dehalococcoidia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_48531_1 378806.STAUR_7113 7.95e-23 101.0 COG0642@1|root,COG2205@2|Bacteria,1QX4R@1224|Proteobacteria,4301I@68525|delta/epsilon subdivisions,2WVE5@28221|Deltaproteobacteria 28221|Deltaproteobacteria T MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - - - - - - - - - - HATPase_c,HisKA,MEDS k59_126866_2 1255043.TVNIR_1353 8.79e-107 322.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF1329,DUF4367,LolA_like,MucB_RseB,Sigma70_r2,Sigma70_r4_2 k59_61657_1 335543.Sfum_2387 9.78e-56 191.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2MSKS@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM major facilitator superfamily MFS_1 - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_42602_1 635013.TherJR_0179 2.87e-26 112.0 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,266W1@186807|Peptococcaceae 186801|Clostridia M PFAM PpiC-type peptidyl-prolyl cis-trans isomerase prsA - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_113318_1 795359.TOPB45_1601 5.21e-44 153.0 COG1013@1|root,COG1013@2|Bacteria,2GHBX@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_113318_2 1123371.ATXH01000004_gene1680 5.19e-14 72.8 COG0674@1|root,COG0674@2|Bacteria,2GGZK@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C ferredoxin oxidoreductase - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_138920_1 335543.Sfum_3505 1.22e-49 165.0 29HYV@1|root,304VW@2|Bacteria,1RDPY@1224|Proteobacteria,42RXW@68525|delta/epsilon subdivisions,2WNTT@28221|Deltaproteobacteria,2MS5G@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_138920_2 1121405.dsmv_2993 5.55e-21 87.4 COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria,2MPA2@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_165069_1 439235.Dalk_1424 1.23e-26 115.0 COG0697@1|root,COG0784@1|root,COG4191@1|root,COG0697@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MMRD@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_204027_1 1049564.TevJSym_ak00150 2.12e-125 389.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5KS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_120244_2 765910.MARPU_08030 1.17e-90 277.0 COG2138@1|root,COG2138@2|Bacteria,1R8AE@1224|Proteobacteria,1S06H@1236|Gammaproteobacteria,1WVZC@135613|Chromatiales 135613|Chromatiales S PFAM cobalamin (vitamin B12) biosynthesis CbiX - - - - - - - - - - - - CbiX k59_120244_3 1150626.PHAMO_380036 2.33e-284 791.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2JQZQ@204441|Rhodospirillales 204441|Rhodospirillales C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - 1.12.1.2 ko:K00124,ko:K18005 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S k59_120244_4 1316936.K678_14222 0.0 959.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1MUM1@1224|Proteobacteria,2TUBH@28211|Alphaproteobacteria,2JVC3@204441|Rhodospirillales 204441|Rhodospirillales C Iron only hydrogenase large subunit, C-terminal domain - - 1.12.1.2 ko:K18006 - - - - ko00000,ko01000 - - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,NADH-G_4Fe-4S_3 k59_120244_5 1150469.RSPPHO_00583 3.44e-238 666.0 COG0502@1|root,COG0502@2|Bacteria,1MXK0@1224|Proteobacteria,2U0XI@28211|Alphaproteobacteria,2JVY1@204441|Rhodospirillales 204441|Rhodospirillales C Biotin and Thiamin Synthesis associated domain - - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k59_120244_6 1150469.RSPPHO_00584 1.8e-208 590.0 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2TVZD@28211|Alphaproteobacteria,2JYUB@204441|Rhodospirillales 204441|Rhodospirillales E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_87385_1 1265505.ATUG01000002_gene1876 1.52e-50 171.0 COG0509@1|root,COG0509@2|Bacteria,1NRFW@1224|Proteobacteria,42ZAN@68525|delta/epsilon subdivisions,2WUQI@28221|Deltaproteobacteria,2MMY2@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H k59_87385_2 1265505.ATUG01000002_gene1875 7.72e-64 204.0 COG0509@1|root,COG0509@2|Bacteria,1RFR3@1224|Proteobacteria,42S58@68525|delta/epsilon subdivisions,2WNK3@28221|Deltaproteobacteria,2MN5C@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H k59_158739_1 56780.SYN_01441 8.02e-27 110.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MRA2@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_158739_2 1121430.JMLG01000031_gene1633 4.49e-06 48.5 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae 186801|Clostridia P pyridine nucleotide-disulphide oxidoreductase dimerisation - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_133041_2 29486.NJ56_11630 3.66e-45 149.0 COG3620@1|root,COG3620@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_31 k59_35753_1 1287276.X752_10945 1.67e-11 73.6 COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R3R7@1224|Proteobacteria,2U3BY@28211|Alphaproteobacteria,43NNM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Forkhead associated domain - - - ko:K11894 - - - - ko00000,ko02044 3.A.23.1 - - FHA k59_171803_2 1121957.ATVL01000010_gene149 3.44e-10 68.2 COG2259@1|root,COG2259@2|Bacteria,4NK73@976|Bacteroidetes,47QQ2@768503|Cytophagia 976|Bacteroidetes S Doxx family - - - - - - - - - - - - - k59_61667_1 1121406.JAEX01000002_gene805 1.13e-30 117.0 COG1035@1|root,COG1152@1|root,COG1035@2|Bacteria,COG1152@2|Bacteria,1R4GN@1224|Proteobacteria,42P9J@68525|delta/epsilon subdivisions,2WJ9S@28221|Deltaproteobacteria,2MGKM@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.17.1.9 ko:K00125 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer4,Fer4_17,FrhB_FdhB_C k59_61667_2 335543.Sfum_0821 6.74e-57 197.0 COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg k59_126879_1 452637.Oter_3802 3.89e-219 636.0 COG0841@1|root,COG0841@2|Bacteria,46SDW@74201|Verrucomicrobia,3K7E7@414999|Opitutae 414999|Opitutae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_2758_1 767817.Desgi_4687 3.5e-24 106.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,260S8@186807|Peptococcaceae 186801|Clostridia C PFAM Radical SAM scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_48550_1 96561.Dole_2808 5.77e-21 94.4 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2X72U@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_54741_1 626887.J057_08786 3.92e-43 180.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_113326_1 1122201.AUAZ01000002_gene1133 1.86e-68 218.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,4679W@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_197202_1 339670.Bamb_0758 4.13e-192 576.0 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,2VHEA@28216|Betaproteobacteria,1K2KJ@119060|Burkholderiaceae 28216|Betaproteobacteria M Glycosyl transferases group 1 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_51091_2 1123253.AUBD01000001_gene1478 6.19e-35 124.0 2A916@1|root,30Y54@2|Bacteria,1RF9B@1224|Proteobacteria,1SR1Q@1236|Gammaproteobacteria,1X766@135614|Xanthomonadales 135614|Xanthomonadales S Bacteriophage lambda head decoration protein D - - - - - - - - - - - - HDPD k59_115642_1 1121405.dsmv_1666 2.83e-177 531.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_173588_1 493475.GARC_4830 1.01e-59 200.0 COG0476@1|root,COG0476@2|Bacteria,1R4EI@1224|Proteobacteria,1SKFM@1236|Gammaproteobacteria,469DD@72275|Alteromonadaceae 1236|Gammaproteobacteria H ThiF family - - - - - - - - - - - - ThiF k59_12341_1 1454004.AW11_03335 2.69e-96 299.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1KPQ7@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_129617_2 1121918.ARWE01000001_gene188 4.13e-46 153.0 COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,42TD7@68525|delta/epsilon subdivisions,2WPIH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Predicted membrane protein (DUF2177) - - - - - - - - - - - - DUF2177 k59_129617_3 1499967.BAYZ01000048_gene2702 5.44e-113 331.0 COG3752@1|root,COG3752@2|Bacteria,2NR3R@2323|unclassified Bacteria 2|Bacteria S 3-oxo-5-alpha-steroid 4-dehydrogenase yfhH - 1.3.1.22 ko:K12343 ko00140,map00140 - R02208,R02497,R08954,R10242 RC00145 ko00000,ko00001,ko01000 - - - DUF1295 k59_109526_1 1470591.BW41_01682 2.72e-21 99.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,2K252@204457|Sphingomonadales 204457|Sphingomonadales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_38538_1 1265503.KB905160_gene2856 2.33e-82 256.0 COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,1RYNH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_6 k59_141572_1 870187.Thini_4021 1.56e-81 244.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,1S5CH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Nitrogen fixation protein - - - - - - - - - - - - DUF269 k59_141572_2 1396858.Q666_09970 1.64e-14 73.9 COG3086@1|root,COG3086@2|Bacteria,1N6QS@1224|Proteobacteria,1SCTM@1236|Gammaproteobacteria,468GR@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG3086 Positive regulator of sigma E activity rseC GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k59_141572_3 870187.Thini_4019 7.85e-70 215.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,1S50W@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Dinitrogenase iron-molybdenum cofactor nifX - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_141572_4 870187.Thini_3483 5.34e-238 666.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,1RPBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the NifD NifK NifE NifN family nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_141572_5 765911.Thivi_2740 3.31e-54 184.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,1RQ8X@1236|Gammaproteobacteria,1WW6F@135613|Chromatiales 135613|Chromatiales C Belongs to the NifD NifK NifE NifN family - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_4856_1 1121106.JQKB01000049_gene3059 1.06e-91 322.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_7,PAS_9,dCache_2 k59_70918_2 1049564.TevJSym_aa00220 3.11e-275 758.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1J5AU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_135411_1 443143.GM18_4034 2.83e-10 61.2 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_135411_2 1232410.KI421425_gene1549 2.27e-61 214.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_148279_1 42256.RradSPS_2196 2.05e-63 210.0 COG0415@1|root,COG0415@2|Bacteria 2|Bacteria L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_180741_1 1122997.AUDD01000003_gene510 3.26e-37 135.0 COG4832@1|root,COG4832@2|Bacteria,2GN4K@201174|Actinobacteria,4DQBQ@85009|Propionibacteriales 201174|Actinobacteria S GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like k59_180741_2 526222.Desal_2703 5.22e-84 261.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42RC6@68525|delta/epsilon subdivisions,2WN72@28221|Deltaproteobacteria,2MA1Z@213115|Desulfovibrionales 28221|Deltaproteobacteria K transcription activator, effector binding - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 k59_180741_4 1117943.SFHH103_02750 1.81e-114 334.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria,4BEAI@82115|Rhizobiaceae 28211|Alphaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003,ko:K05685 ko02010,map02010 M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 - - ABC_tran k59_187703_1 388399.SSE37_12374 5.73e-37 144.0 2C10Y@1|root,33VU3@2|Bacteria,1RFVX@1224|Proteobacteria,2U8EA@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_18079_1 273075.Ta0629 2.47e-19 87.0 COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2426J@183967|Thermoplasmata 183967|Thermoplasmata C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1,1.2.7.7 ko:K00170,ko:K00187 ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R07160,R08034,R08566,R08567 RC00004,RC00250,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_97228_1 56780.SYN_02036 2.07e-106 331.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2MQ7A@213462|Syntrophobacterales 28221|Deltaproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_102458_1 339671.Asuc_1458 2.85e-13 66.2 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1Y8VR@135625|Pasteurellales 135625|Pasteurellales J RNA-binding protein containing KH domain, possibly ribosomal protein VY92_07230 - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_102458_2 1049564.TevJSym_ap00690 2.86e-110 321.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1J4TW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_18082_1 314278.NB231_14168 8.65e-96 289.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WX7H@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_31381_1 2340.JV46_27210 2.37e-76 244.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7AF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_31381_3 1038869.AXAN01000247_gene2193 2.7e-07 53.1 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria,1K7N5@119060|Burkholderiaceae 28216|Betaproteobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_29,HTH_32,HTH_33 k59_64226_1 644282.Deba_0295 9.79e-07 51.6 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_187715_1 713586.KB900536_gene1629 3.4e-106 325.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_109551_1 1049564.TevJSym_as00660 3.01e-63 214.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family IV02_10640 - - ko:K07003 - - - - ko00000 - - - MMPL k59_109551_2 1255043.TVNIR_1352 6.02e-07 50.1 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria 1236|Gammaproteobacteria T N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - AMIN k59_141579_1 1049564.TevJSym_av00330 3.37e-48 169.0 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1JB68@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_187716_1 1484157.PSNIH2_13400 3.9e-121 365.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,1RY0J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_18099_1 351348.Maqu_0236 2.44e-112 330.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,46ABE@72275|Alteromonadaceae 1236|Gammaproteobacteria L DDE domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_70940_1 572477.Alvin_0546 4.55e-128 411.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_18105_1 552811.Dehly_0447 8.98e-118 350.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia 301297|Dehalococcoidia L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_18105_2 931627.MycrhDRAFT_6261 5.78e-09 56.2 COG2963@1|root,COG2963@2|Bacteria,2GRDS@201174|Actinobacteria,23EYP@1762|Mycobacteriaceae 201174|Actinobacteria L PFAM Transposase IS3 IS911family - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_135758_1 349521.HCH_00085 1.87e-33 145.0 COG3291@1|root,COG3291@2|Bacteria,1PFDE@1224|Proteobacteria,1RWU9@1236|Gammaproteobacteria,1XNU8@135619|Oceanospirillales 2|Bacteria M PKD domain - - 3.2.1.4,3.2.1.91 ko:K01179,ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R06200,R11307,R11308 RC00799 ko00000,ko00001,ko01000 - GH5,GH6,GH9 - CBM_10,CBM_2,Cadherin-like,Calycin_like,CelD_N,FIVAR,Glyco_hydro_9,PCMD,PKD,RicinB_lectin_2,SLH k59_173949_1 411473.RUMCAL_00855 2.44e-07 52.0 COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,248NH@186801|Clostridia,3WGYP@541000|Ruminococcaceae 186801|Clostridia E carboxynorspermidine decarboxylase nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC k59_173949_3 1283300.ATXB01000001_gene2260 1.38e-41 139.0 COG3744@1|root,COG3744@2|Bacteria,1QF34@1224|Proteobacteria,1TC5A@1236|Gammaproteobacteria,1XGTN@135618|Methylococcales 135618|Methylococcales S PIN domain - - - - - - - - - - - - PIN k59_5169_1 1049564.TevJSym_ac00800 5.08e-53 183.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1J5J8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat k59_5169_2 1049564.TevJSym_ac00820 1.8e-55 182.0 COG1716@1|root,COG1716@2|Bacteria,1PGN8@1224|Proteobacteria,1SEK2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T FHA domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_51463_2 1117314.PCIT_21699 4.21e-57 181.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,2Q26F@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_102742_1 706587.Desti_5386 1e-91 279.0 COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,42TZD@68525|delta/epsilon subdivisions,2WQIE@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Phosphonate ABC transporter, periplasmic - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_5171_1 765914.ThisiDRAFT_0663 5.55e-59 206.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Phosphonate-bd,Response_reg k59_199883_1 472759.Nhal_2359 4.26e-70 231.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_115959_2 596151.DesfrDRAFT_2451 4.84e-27 117.0 COG0535@1|root,COG0535@2|Bacteria,1R4I0@1224|Proteobacteria,42MFB@68525|delta/epsilon subdivisions,2X02W@28221|Deltaproteobacteria,2MA4M@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_115959_3 767434.Fraau_0287 2.02e-15 85.9 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1X32K@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the radical SAM superfamily. PqqE family pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_115959_4 580331.Thit_1567 1.01e-10 71.2 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,42EMK@68295|Thermoanaerobacterales 186801|Clostridia C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_115959_5 760154.Sulba_2459 3.63e-33 132.0 COG0535@1|root,COG0535@2|Bacteria,1PEYS@1224|Proteobacteria,42SNS@68525|delta/epsilon subdivisions,2YQGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - Radical_SAM,SPASM k59_115959_6 887929.HMP0721_1183 7.41e-37 147.0 COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,25ZHC@186806|Eubacteriaceae 186801|Clostridia C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_154865_1 879212.DespoDRAFT_00063 4.44e-42 144.0 COG0071@1|root,COG0071@2|Bacteria,1RE2H@1224|Proteobacteria,42RP0@68525|delta/epsilon subdivisions,2WNC4@28221|Deltaproteobacteria,2MK0Y@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_115962_1 1121405.dsmv_3545 7.06e-69 220.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2MJ5F@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM Bile acid sodium symporter arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_115962_2 335543.Sfum_3600 6.47e-35 123.0 COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MRPZ@213462|Syntrophobacterales 28221|Deltaproteobacteria C Putative Fe-S cluster - - - - - - - - - - - - FeS k59_161662_1 90813.JQMT01000001_gene1669 2.59e-165 468.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,463S8@72273|Thiotrichales 72273|Thiotrichales L Integrase core domain - - - - - - - - - - - - HTH_29,rve k59_18505_1 765913.ThidrDRAFT_1143 1.01e-52 176.0 COG3415@1|root,COG3415@2|Bacteria,1QWT2@1224|Proteobacteria,1T5A1@1236|Gammaproteobacteria,1X2VP@135613|Chromatiales 1236|Gammaproteobacteria L PFAM Transposase, Rhodopirellula-type - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_161663_2 247490.KSU1_C1421 4.28e-22 91.3 COG3666@1|root,COG3666@2|Bacteria 2|Bacteria - - - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_148617_1 2340.JV46_04030 4.03e-49 164.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,1J9MC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_148617_2 1313421.JHBV01000029_gene1910 5.97e-11 63.9 29525@1|root,2ZSEY@2|Bacteria,4P23W@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_148617_3 1131553.JIBI01000018_gene516 7.92e-34 141.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_16,TonB_dep_Rec k59_206595_1 395494.Galf_1309 1.31e-18 86.7 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_206595_2 395494.Galf_1307 3.71e-164 508.0 COG0642@1|root,COG0784@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2VJVN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE5,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_167762_1 765911.Thivi_4300 1.28e-43 161.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,1SBWP@1236|Gammaproteobacteria,1WZ1F@135613|Chromatiales 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_161666_1 1121405.dsmv_2608 4.03e-136 394.0 COG0498@1|root,COG0498@2|Bacteria 2|Bacteria E threonine synthase activity - - 2.5.1.76,4.2.3.1 ko:K01733,ko:K15527 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,PALP k59_57087_1 1049564.TevJSym_ak00700 9.02e-23 94.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1J5SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase ramA - 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_102765_1 314278.NB231_10293 1.29e-57 204.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales 135613|Chromatiales E PFAM NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_5198_1 416591.Tlet_0520 9.46e-36 128.0 COG1327@1|root,COG1327@2|Bacteria,2GCWA@200918|Thermotogae 200918|Thermotogae K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_5198_2 269799.Gmet_1622 1.16e-56 181.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,43U1G@69541|Desulfuromonadales 28221|Deltaproteobacteria F PFAM CMP dCMP deaminase zinc-binding comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_135794_1 765912.Thimo_2767 1.47e-29 107.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1WYUA@135613|Chromatiales 135613|Chromatiales G Phosphotransferase System - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_184104_2 1517416.IDAT_07865 1.05e-57 191.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria 1236|Gammaproteobacteria M rhs family - - - - - - - - - - - - RHS,RHS_repeat k59_99161_2 339670.Bamb_6596 3.05e-47 159.0 2921C@1|root,2ZPKK@2|Bacteria,1REBZ@1224|Proteobacteria,2VU5W@28216|Betaproteobacteria,1K886@119060|Burkholderiaceae 28216|Betaproteobacteria S Antirestriction protein - - - - - - - - - - - - Antirestrict k59_105811_1 408672.NBCG_02271 8.19e-15 75.9 COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4DR8I@85009|Propionibacteriales 201174|Actinobacteria K Uncharacterized ACR, COG1678 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_177360_1 335543.Sfum_3070 1.29e-225 644.0 COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MR2F@213462|Syntrophobacterales 28221|Deltaproteobacteria C acetyl-CoA - - - ko:K18122,ko:K18288 ko00650,ko00660,ko01100,ko01200,map00650,map00660,map01100,map01200 - R02407,R05336,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - iAF987.Gmet_2142,iAF987.Gmet_3304 AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3 k59_34747_1 439235.Dalk_0297 3.28e-25 106.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_41415_2 83406.HDN1F_31380 6.41e-116 332.0 COG0454@1|root,COG0454@2|Bacteria,1QUS5@1224|Proteobacteria,1S5GV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K -acetyltransferase - - - - - - - - - - - - Acetyltransf_10 k59_41415_3 243265.plu3889 7.66e-55 173.0 COG4453@1|root,COG4453@2|Bacteria,1N85C@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_14741_1 1121405.dsmv_2938 9.93e-102 313.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,42P5R@68525|delta/epsilon subdivisions,2WJDU@28221|Deltaproteobacteria,2MI4P@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_125665_1 111780.Sta7437_0512 2.02e-10 67.0 COG0517@1|root,COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4251@1|root,COG0517@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,3VJG3@52604|Pleurocapsales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_93271_1 1454004.AW11_03318 1.5e-156 447.0 COG0464@1|root,COG0464@2|Bacteria,1NF48@1224|Proteobacteria,2VK2M@28216|Betaproteobacteria 28216|Betaproteobacteria O PFAM AAA ATPase central domain protein - - - - - - - - - - - - AAA k59_93271_2 1454004.AW11_03317 1.59e-244 697.0 COG1404@1|root,COG1404@2|Bacteria,1ND93@1224|Proteobacteria,2VKTR@28216|Betaproteobacteria 28216|Betaproteobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_144998_1 555779.Dthio_PD2276 3.57e-148 428.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MEE0@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_144998_2 472759.Nhal_3099 1.08e-79 243.0 COG0438@1|root,COG0438@2|Bacteria,1RA8H@1224|Proteobacteria,1S3Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_73308_1 1121013.P873_02005 1.76e-17 82.4 COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,1SD4H@1236|Gammaproteobacteria,1X7SY@135614|Xanthomonadales 135614|Xanthomonadales G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_151460_1 742159.HMPREF0004_5165 1.09e-53 182.0 COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2VHM1@28216|Betaproteobacteria 28216|Betaproteobacteria EQ PFAM peptidase S58, DmpA - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_177372_1 1121447.JONL01000005_gene1412 3.14e-78 255.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2M9AS@213115|Desulfovibrionales 28221|Deltaproteobacteria C Formate dehydrogenase, alpha subunit - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016622,GO:0016903,GO:0018282,GO:0018289,GO:0018291,GO:0019538,GO:0022607,GO:0031163,GO:0032991,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0047111,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:1901564,GO:1902494 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_93279_1 105559.Nwat_0489 2.88e-26 105.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_119177_1 317025.Tcr_0864 1.43e-53 188.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,461T0@72273|Thiotrichales 72273|Thiotrichales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_196324_1 1380394.JADL01000010_gene4323 1.51e-229 653.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales 204441|Rhodospirillales C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_60598_1 396595.TK90_2582 4.42e-56 179.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales 135613|Chromatiales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_60598_2 1049564.TevJSym_bh00170 4.05e-176 496.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1J5A8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_60598_3 1049564.TevJSym_bh00150 2.39e-130 386.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1J5FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_34764_1 234267.Acid_0012 1.21e-25 111.0 COG0587@1|root,COG0587@2|Bacteria,3Y2TS@57723|Acidobacteria 57723|Acidobacteria L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_14752_1 745411.B3C1_13134 2.91e-59 188.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1J4HA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the SUA5 family yciO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Sua5_yciO_yrdC k59_14752_2 765911.Thivi_1152 5.53e-109 323.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1WXKB@135613|Chromatiales 135613|Chromatiales S pfam php - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_53902_3 1197719.A464_3144 1.8e-20 84.3 2B1GR@1|root,31TXQ@2|Bacteria,1QRRC@1224|Proteobacteria,1TC77@1236|Gammaproteobacteria,3ZNCP@590|Salmonella 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_53902_4 626418.bglu_1g23320 3.87e-120 358.0 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2VS1K@28216|Betaproteobacteria,1K98W@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2169) - - - - - - - - - - - - DUF2169 k59_21925_1 1304885.AUEY01000118_gene2868 5.96e-133 403.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_67116_1 1049564.TevJSym_bn00010 1.23e-79 258.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J59N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_106003_1 324925.Ppha_2544 5.95e-50 166.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_73432_1 1049564.TevJSym_ag00360 3.09e-98 288.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1J52V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_112616_1 880072.Desac_0501 2e-54 199.0 COG2202@1|root,COG2204@1|root,COG3290@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_171202_1 56780.SYN_00551 1.64e-84 272.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MQ74@213462|Syntrophobacterales 28221|Deltaproteobacteria M Penicillin-binding protein, dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_151625_1 768066.HELO_1537 1.53e-14 72.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XHS2@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamine synthetase family - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_151625_2 399739.Pmen_0677 4.2e-240 671.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1YF1V@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_151625_3 349521.HCH_06318 2.08e-209 587.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1XIWQ@135619|Oceanospirillales 135619|Oceanospirillales C alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_151625_4 745014.OMB55_00023330 1.3e-28 110.0 COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S2MK@1236|Gammaproteobacteria 1236|Gammaproteobacteria F glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_106008_1 335543.Sfum_2689 3.81e-130 396.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MQ5F@213462|Syntrophobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_177578_1 1121434.AULY01000007_gene1334 4.47e-17 80.1 COG2181@1|root,COG2181@2|Bacteria,1RADK@1224|Proteobacteria,42RA7@68525|delta/epsilon subdivisions,2WMPI@28221|Deltaproteobacteria,2M90P@213115|Desulfovibrionales 28221|Deltaproteobacteria C nitrate reductase activity hmcE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Nitrate_red_gam k59_177578_2 555779.Dthio_PD1031 8.24e-15 75.1 COG0247@1|root,COG0247@2|Bacteria,1R467@1224|Proteobacteria,42Z6B@68525|delta/epsilon subdivisions,2WU13@28221|Deltaproteobacteria,2MH5B@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17 k59_196503_1 331678.Cphamn1_0098 1.1e-82 258.0 COG0743@1|root,COG0743@2|Bacteria,1FD70@1090|Chlorobi 1090|Chlorobi I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_196503_2 1330700.JQNC01000003_gene367 1.91e-33 124.0 COG0575@1|root,COG0575@2|Bacteria,1WNDM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the CDS family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_67124_1 111105.HR09_03835 1.31e-26 110.0 COG0769@1|root,COG0769@2|Bacteria,4NE9W@976|Bacteroidetes,2FM8E@200643|Bacteroidia,22W0E@171551|Porphyromonadaceae 976|Bacteroidetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_164341_1 317025.Tcr_0334 2.1e-175 524.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,45ZT7@72273|Thiotrichales 72273|Thiotrichales L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_164341_2 1396858.Q666_15470 3.36e-139 407.0 COG0758@1|root,COG0758@2|Bacteria,1Q7YP@1224|Proteobacteria,1RYGJ@1236|Gammaproteobacteria,46ACG@72275|Alteromonadaceae 1236|Gammaproteobacteria LU DNA recombination-mediator protein A - - - - - - - - - - - - DNA_processg_A k59_93466_2 1443113.LC20_04021 1.76e-56 186.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,41DXK@629|Yersinia 1236|Gammaproteobacteria J Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_93466_5 768671.ThimaDRAFT_2358 3.55e-216 609.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1WXAG@135613|Chromatiales 135613|Chromatiales E PFAM sodium alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_93466_9 1249627.D779_1819 9.93e-20 85.1 COG0662@1|root,COG0662@2|Bacteria,1QUHG@1224|Proteobacteria,1T1Z6@1236|Gammaproteobacteria,1WZ1B@135613|Chromatiales 135613|Chromatiales G PFAM Cupin 2, conserved barrel - - - ko:K11312 - - - - ko00000 - - - Cupin_2 k59_125825_1 765912.Thimo_2397 4.4e-140 426.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_73440_1 177439.DP0650 1.11e-71 241.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_132314_1 555088.DealDRAFT_1856 2.28e-07 53.5 COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,248YH@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - GyrI-like k59_125828_1 760568.Desku_1358 5.4e-76 235.0 COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,26044@186807|Peptococcaceae 186801|Clostridia C Fe-S type, tartrate fumarate subfamily, alpha - - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase k59_80391_1 1331060.RLDS_01595 9.82e-39 146.0 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria,2K2T8@204457|Sphingomonadales 204457|Sphingomonadales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_41649_1 2340.JV46_12060 1.26e-152 451.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1J51W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1032 Fe-S oxidoreductase ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_41649_2 29486.NJ56_15245 5.53e-14 70.1 COG0633@1|root,COG0633@2|Bacteria,1QU91@1224|Proteobacteria,1T1VI@1236|Gammaproteobacteria,41GJ0@629|Yersinia 1236|Gammaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain yfaE - - ko:K11107 - - - - ko00000 - - - Fer2 k59_41649_3 1049564.TevJSym_aj00420 1.32e-62 196.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1J70E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the small heat shock protein (HSP20) family hspA - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_41649_5 1415780.JPOG01000001_gene2201 9.1e-67 217.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,1X5AX@135614|Xanthomonadales 135614|Xanthomonadales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_54038_1 323261.Noc_1063 3.34e-106 356.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,1S0ET@1236|Gammaproteobacteria 1236|Gammaproteobacteria PT FecR protein - - - - - - - - - - - - FecR,TPR_16,TPR_19,TonB_dep_Rec k59_73443_1 1304885.AUEY01000001_gene3312 2.38e-60 205.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_157963_1 1049564.TevJSym_ao00610 3.4e-136 400.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1J4M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S glutamate--cysteine ligase ybdK_1 - - - - - - - - - - - GCS2 k59_14933_1 335543.Sfum_2677 4.85e-42 156.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,42N57@68525|delta/epsilon subdivisions,2WJ82@28221|Deltaproteobacteria,2MRA8@213462|Syntrophobacterales 28221|Deltaproteobacteria F HELICc2 yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_112629_1 519989.ECTPHS_11095 2.62e-148 429.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1WWEG@135613|Chromatiales 135613|Chromatiales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_67140_1 498211.CJA_2530 4.41e-07 50.4 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1FGNC@10|Cellvibrio 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0000166,GO:0000900,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004829,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006435,GO:0006446,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0017076,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0030371,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032553,GO:0032555,GO:0032559,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045947,GO:0046483,GO:0046872,GO:0046914,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097367,GO:0106074,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iPC815.YPO2433,iSDY_1059.SDY_1814 HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_67140_2 765913.ThidrDRAFT_4145 3.61e-37 139.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWAU@135613|Chromatiales 135613|Chromatiales U Hydrophobe Amphiphile Efflux-1 (HAE1) - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_184289_3 1442599.JAAN01000030_gene2131 3.08e-68 225.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,1X4UP@135614|Xanthomonadales 135614|Xanthomonadales M secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_8977_1 1049564.TevJSym_bu00010 4.98e-293 814.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_73449_1 1121921.KB898713_gene1727 2.51e-09 62.4 COG0642@1|root,COG3300@1|root,COG2205@2|Bacteria,COG3300@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2PP80@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_9,Response_reg k59_171214_1 396588.Tgr7_2173 2.91e-78 247.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1WW79@135613|Chromatiales 135613|Chromatiales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_125841_1 1049564.TevJSym_aa01110 7.02e-143 412.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1J4CN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_132328_1 1049564.TevJSym_ax00230 2.57e-78 249.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1J555@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_93487_1 177437.HRM2_07800 1.52e-74 236.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MKDA@213118|Desulfobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_190471_2 1049564.TevJSym_ai00660 5.2e-317 892.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1J9D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - DsbC,GlcNAc_2-epim,Thioredox_DsbH k59_153242_1 1396418.BATQ01000120_gene3064 7.53e-32 116.0 COG4566@1|root,COG4566@2|Bacteria,46VMR@74201|Verrucomicrobia,2IW32@203494|Verrucomicrobiae 203494|Verrucomicrobiae T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_23977_1 983545.Glaag_0155 4.88e-107 322.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,465PV@72275|Alteromonadaceae 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_88516_3 1278307.KB907057_gene2644 4.51e-115 343.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_192203_1 870187.Thini_0800 1.49e-107 324.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_101079_1 234267.Acid_5892 2.32e-64 214.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - ko:K22318 - - - - ko00000 - - - B12-binding,Radical_SAM k59_44226_2 289377.HL41_05015 1.52e-05 46.6 COG1758@1|root,COG1758@2|Bacteria,2GHZJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_166099_2 1298867.AUES01000005_gene65 5.34e-29 116.0 COG4626@1|root,COG4626@2|Bacteria,1MW9D@1224|Proteobacteria,2TVMI@28211|Alphaproteobacteria,3JX3N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Terminase - - - - - - - - - - - - - k59_30161_1 1265505.ATUG01000002_gene2702 6.98e-90 267.0 COG0607@1|root,COG0607@2|Bacteria,1RA3A@1224|Proteobacteria,42QNH@68525|delta/epsilon subdivisions,2WMPB@28221|Deltaproteobacteria,2MJIC@213118|Desulfobacterales 28221|Deltaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - MauE,Rhodanese k59_69416_2 266809.PM03_00820 7.11e-09 60.1 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria 28211|Alphaproteobacteria U COG0457 FOG TPR repeat MA20_42300 - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_44227_1 439235.Dalk_4515 4.74e-127 380.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,43CRI@68525|delta/epsilon subdivisions,2X7Z7@28221|Deltaproteobacteria,2MIWI@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_198265_1 1286106.MPL1_12508 6.75e-236 653.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RWC8@1236|Gammaproteobacteria,460AJ@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - LeuA_dimer,PALP k59_198265_2 314282.PCNPT3_01385 1.39e-105 332.0 COG2244@1|root,COG2244@2|Bacteria,1RIXW@1224|Proteobacteria,1SGVV@1236|Gammaproteobacteria,2QH91@267894|Psychromonadaceae 1236|Gammaproteobacteria S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt_3 k59_198265_3 1278307.KB906973_gene1348 2.07e-94 295.0 COG0726@1|root,COG0726@2|Bacteria,1P78Y@1224|Proteobacteria,1TDBB@1236|Gammaproteobacteria,2QHKN@267894|Psychromonadaceae 1236|Gammaproteobacteria G polysaccharide deacetylase - - - - - - - - - - - - - k59_198265_4 1278307.KB906973_gene1354 5.54e-121 362.0 COG0438@1|root,COG0438@2|Bacteria,1RCC7@1224|Proteobacteria,1S51S@1236|Gammaproteobacteria,2QHC3@267894|Psychromonadaceae 1236|Gammaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_198265_5 1203190.CAJP01000003_gene507 5.54e-06 56.6 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,22KCT@1653|Corynebacteriaceae 201174|Actinobacteria M Glycosyltransferase, group 1 family protein pimB GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_134102_1 933262.AXAM01000083_gene762 2.64e-138 400.0 COG0426@1|root,COG0426@2|Bacteria,1R4UD@1224|Proteobacteria,43AF5@68525|delta/epsilon subdivisions,2X5UW@28221|Deltaproteobacteria,2MPG5@213118|Desulfobacterales 28221|Deltaproteobacteria C Flavodoxin roo - - - - - - - - - - - Flavodoxin_1,Lactamase_B,Lactamase_B_2 k59_128253_2 991.IW20_12590 3.52e-18 85.1 COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,1HXKY@117743|Flavobacteriia,2NTG5@237|Flavobacterium 976|Bacteroidetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_186323_1 396588.Tgr7_3080 1.09e-107 318.0 COG1082@1|root,COG1082@2|Bacteria,1Q3WR@1224|Proteobacteria,1S04R@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 k59_186323_2 396588.Tgr7_3090 6.46e-250 707.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,1WXE4@135613|Chromatiales 135613|Chromatiales J Allophanate hydrolase - - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - Amidase k59_160036_1 96561.Dole_1573 3.11e-108 328.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2MJ6V@213118|Desulfobacterales 28221|Deltaproteobacteria G Domain of unknown function (DUF4147) - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_55636_2 326297.Sama_1463 7.98e-54 181.0 COG3203@1|root,COG3203@2|Bacteria,1QYZC@1224|Proteobacteria,1T3Y7@1236|Gammaproteobacteria,2Q951@267890|Shewanellaceae 1236|Gammaproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD k59_30162_1 1453501.JELR01000001_gene2567 1.35e-56 206.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RYVF@1236|Gammaproteobacteria,465ZJ@72275|Alteromonadaceae 1236|Gammaproteobacteria S Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - AAA_29,SbcCD_C k59_146953_1 234267.Acid_2554 7.3e-150 436.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_128255_1 635013.TherJR_2804 7.04e-07 52.4 COG2199@1|root,COG3706@2|Bacteria,1V2QN@1239|Firmicutes,249KZ@186801|Clostridia 186801|Clostridia T TIGRFAM Diguanylate cyclase - - 2.7.7.65 ko:K18967 - - - - ko00000,ko01000,ko02000 9.B.34.1.1 - - 5TM-5TMR_LYT,GGDEF k59_88527_1 933262.AXAM01000013_gene1310 3.22e-67 228.0 COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MINB@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidase M16C associated PREP - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_30164_1 1123368.AUIS01000014_gene2323 3.45e-24 103.0 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,2NCU8@225057|Acidithiobacillales 225057|Acidithiobacillales S Glycosyltransferase like family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 k59_134104_1 1122599.AUGR01000002_gene3386 2.81e-84 258.0 2DP71@1|root,330U0@2|Bacteria,1R5A0@1224|Proteobacteria,1RS7S@1236|Gammaproteobacteria,1XM3N@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2971) - - - - - - - - - - - - DUF2971 k59_179491_2 243233.MCA1113 1.04e-104 313.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XDK1@135618|Methylococcales 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_44238_2 1049564.TevJSym_ci00020 6.72e-18 79.0 2DQWF@1|root,3392H@2|Bacteria,1N93V@1224|Proteobacteria,1SFNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2934) - - - - - - - - - - - - DUF2934 k59_108132_1 1049564.TevJSym_ac01130 2.6e-160 454.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1J5ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M UTP--glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_108132_2 1049564.TevJSym_ac01140 1.51e-110 324.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1J5PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 OMPdecase k59_153259_1 1121468.AUBR01000026_gene2939 2.68e-23 98.2 COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia 186801|Clostridia E Aminotransferase yhdR - 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_153259_2 877421.AUJT01000033_gene3399 1.05e-38 139.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,27QT0@186928|unclassified Lachnospiraceae 186801|Clostridia M GDP-mannose 4,6 dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_140137_1 1049564.TevJSym_as00390 1.52e-143 419.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1J4I5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component gtrB - - - - - - - - - - - DctM k59_88529_1 1049564.TevJSym_af00200 9.54e-184 522.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1J4G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 GATase,GMP_synt_C,NAD_synthase k59_172589_1 1121405.dsmv_0302 3.49e-12 68.2 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_172589_2 933262.AXAM01000066_gene1683 4.46e-62 196.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,2MI5W@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_198271_1 631362.Thi970DRAFT_01621 1.1e-121 357.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1WVWR@135613|Chromatiales 135613|Chromatiales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_198271_2 631362.Thi970DRAFT_01620 5.3e-109 316.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales 135613|Chromatiales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_186332_1 1177181.T9A_02072 3.95e-23 96.7 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XIUA@135619|Oceanospirillales 135619|Oceanospirillales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_186332_2 545276.KB898725_gene792 2.58e-60 198.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales 135613|Chromatiales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_75215_1 1408428.JNJP01000019_gene1642 2.81e-06 53.1 2AHIC@1|root,32DEZ@2|Bacteria,1N6KP@1224|Proteobacteria,42UJC@68525|delta/epsilon subdivisions,2WQYC@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_146961_1 631362.Thi970DRAFT_04361 2.8e-70 220.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1WVWF@135613|Chromatiales 135613|Chromatiales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_44242_2 1121396.KB893069_gene1383 1.05e-61 201.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2WMX3@28221|Deltaproteobacteria,2MJ86@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_114395_1 1049564.TevJSym_ad00560 3.47e-33 127.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2 k59_114395_2 768671.ThimaDRAFT_1751 1.27e-51 173.0 COG0649@1|root,COG0649@2|Bacteria,1R5JW@1224|Proteobacteria,1RT5B@1236|Gammaproteobacteria,1WXBK@135613|Chromatiales 135613|Chromatiales C belongs to the complex I 49 kDa subunit family - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_186333_1 1269813.ATUL01000003_gene2474 2e-57 203.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9 k59_37005_1 1380394.JADL01000008_gene3654 2.44e-07 50.4 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,2U835@28211|Alphaproteobacteria,2JS6A@204441|Rhodospirillales 204441|Rhodospirillales M Polysaccharide biosynthesis/export protein - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_37005_2 1049564.TevJSym_av00220 4.28e-72 231.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1J5KR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - 2.7.10.1 ko:K08252 - - - - ko00000,ko01000 - - - AAA_31 k59_23987_1 665942.HMPREF1022_01563 2.59e-33 132.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BR8@68525|delta/epsilon subdivisions,2X724@28221|Deltaproteobacteria,2MHBC@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Sigma54_activat k59_23987_6 329726.AM1_0523 3.72e-124 365.0 COG1834@1|root,COG1834@2|Bacteria,1G48J@1117|Cyanobacteria 1117|Cyanobacteria E amidinotransferase - - 2.1.4.1 ko:K00613 ko00260,ko00330,ko01100,map00260,map00330,map01100 M00047 R00565,R01989 RC00024,RC02749 ko00000,ko00001,ko00002,ko01000 - - - Amidinotransf k59_192227_2 330214.NIDE3773 6.16e-15 75.1 COG1067@1|root,COG1067@2|Bacteria,3J0X2@40117|Nitrospirae 40117|Nitrospirae O AAA domain - - - - - - - - - - - - AAA_32,Lon_C k59_101103_1 1049564.TevJSym_aa02150 1.83e-113 330.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1JA1Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF455) - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF455 k59_101103_3 1121921.KB898711_gene2102 2.5e-70 222.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,2PNDK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Calcineurin-like phosphoesterase superfamily domain lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 k59_82265_1 243231.GSU3245 2.16e-104 326.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase type-B family polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 k59_160223_1 5827.XP_004225007.1 1.04e-07 61.2 COG0664@1|root,KOG1113@2759|Eukaryota,3Y9W7@5794|Apicomplexa,3KAI4@422676|Aconoidasida,3YWQ0@5819|Haemosporida 422676|Aconoidasida T cAMP-dependent protein kinase - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005952,GO:0019899,GO:0019900,GO:0019901,GO:0032991,GO:0034236,GO:0042802,GO:0044424,GO:0044464,GO:0051018 - ko:K04739 ko04910,map04910 - - - ko00000,ko00001 - - - cNMP_binding k59_82449_1 886293.Sinac_0821 5.91e-87 276.0 COG0589@1|root,COG1914@1|root,COG0589@2|Bacteria,COG1914@2|Bacteria,2J0SG@203682|Planctomycetes 203682|Planctomycetes P Natural resistance-associated macrophage protein mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp k59_49957_1 439235.Dalk_3253 4.99e-113 334.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_114623_1 644282.Deba_1132 1.21e-77 256.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_55865_1 439235.Dalk_3266 6.88e-60 208.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_44482_2 1217715.F994_02760 2.08e-17 86.3 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,3NT02@468|Moraxellaceae 1236|Gammaproteobacteria M RHS Repeat - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_63150_1 314345.SPV1_07401 1.78e-51 174.0 COG2993@1|root,COG2993@2|Bacteria,1NU9D@1224|Proteobacteria 1224|Proteobacteria C Cytochrome C oxidase, mono-heme subunit/FixO - - - - - - - - - - - - FixO k59_172688_1 1049564.TevJSym_ar00460 3.12e-22 95.5 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1J589@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_172688_2 1049564.TevJSym_ar00470 5.61e-92 290.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_166311_1 713587.THITH_04600 8.15e-68 212.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales 135613|Chromatiales L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_186574_1 1121405.dsmv_3743 1.04e-23 97.4 COG0358@1|root,COG0358@2|Bacteria,1N8NW@1224|Proteobacteria,42WR7@68525|delta/epsilon subdivisions,2WS70@28221|Deltaproteobacteria,2MP12@213118|Desulfobacterales 28221|Deltaproteobacteria L Zinc finger, CHC2-type protein - - - - - - - - - - - - zf-CHC2 k59_37256_1 883126.HMPREF9710_05204 5.47e-40 151.0 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2VS1K@28216|Betaproteobacteria,476JZ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2169) - - - - - - - - - - - - DUF2169 k59_30406_1 335543.Sfum_1479 8.97e-94 291.0 COG2414@1|root,COG2414@2|Bacteria,1NT3Z@1224|Proteobacteria,42MU9@68525|delta/epsilon subdivisions,2WKD2@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_55866_1 522306.CAP2UW1_0154 4.92e-86 267.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2VH8K@28216|Betaproteobacteria 28216|Betaproteobacteria E l-serine dehydratase sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_153491_1 1144319.PMI16_03337 2.59e-37 137.0 COG3209@1|root,COG3209@2|Bacteria,1R1SB@1224|Proteobacteria 1224|Proteobacteria M Salmonella virulence plasmid 65kDa B protein - - - - - - - - - - - - SpvB k59_128464_1 1121405.dsmv_0928 2.77e-149 449.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42P9Y@68525|delta/epsilon subdivisions,2WM6A@28221|Deltaproteobacteria,2MJCC@213118|Desulfobacterales 28221|Deltaproteobacteria NTU General secretory system II protein E domain protein - - - - - - - - - - - - GAF,GAF_2,T2SSE,T2SSE_N k59_82460_2 28229.ND2E_3340 1.16e-35 130.0 COG0604@1|root,COG0604@2|Bacteria,1MU4N@1224|Proteobacteria,1RNSV@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_162765_2 519989.ECTPHS_02384 3.19e-36 125.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1WYPN@135613|Chromatiales 135613|Chromatiales C Iron--sulfur cluster insertion protein erpA erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_33031_1 376686.Fjoh_1627 6.67e-06 49.7 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1HYE4@117743|Flavobacteriia,2NT1B@237|Flavobacterium 976|Bacteroidetes T Belongs to the universal stress protein A family uspA - - - - - - - - - - - Usp k59_84919_1 933262.AXAM01000053_gene2707 6.43e-52 174.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2MJ69@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM aminotransferase class I and II - - 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_78582_1 1499967.BAYZ01000112_gene2965 2.58e-33 138.0 COG4262@1|root,COG4262@2|Bacteria 2|Bacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_52485_1 96561.Dole_3014 6.35e-67 206.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,42QRV@68525|delta/epsilon subdivisions,2WMUE@28221|Deltaproteobacteria,2MJY2@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_136775_1 879212.DespoDRAFT_00401 3.63e-29 115.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_136775_2 1265505.ATUG01000002_gene1424 1.31e-38 138.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2MJ27@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_13568_1 933262.AXAM01000010_gene1388 1.54e-79 244.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_7179_1 1535422.ND16A_0183 1.24e-153 456.0 COG3316@1|root,COG3316@2|Bacteria 1535422.ND16A_0183|- - - - - - - - - - - - - - - - k59_117342_1 395494.Galf_1850 1.67e-23 95.1 COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,2W5S7@28216|Betaproteobacteria,44WK1@713636|Nitrosomonadales 28216|Betaproteobacteria S VanZ like family - - - - - - - - - - - - VanZ k59_175611_1 748658.KB907312_gene1550 9.6e-15 75.5 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1WX1N@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_175611_2 1430440.MGMSRv2_0861 2.57e-27 100.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2UFC1@28211|Alphaproteobacteria,2JU9A@204441|Rhodospirillales 204441|Rhodospirillales P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_175611_3 768671.ThimaDRAFT_4230 1.06e-146 438.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales 135613|Chromatiales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_175611_6 1122929.KB908215_gene1124 1.81e-07 52.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator ttdR - - - - - - - - - - - HTH_1,LysR_substrate k59_201705_1 338963.Pcar_3003 4.88e-144 440.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_162773_1 177439.DP2923 7.26e-43 150.0 COG1207@1|root,COG1207@2|Bacteria,1RD3B@1224|Proteobacteria,42ZXX@68525|delta/epsilon subdivisions,2WV9N@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep k59_136776_1 335543.Sfum_0091 1.37e-98 290.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,42QVP@68525|delta/epsilon subdivisions,2WMT7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM cytochrome B561 cbcB - - - - - - - - - - - Ni_hydr_CYTB k59_136776_2 1265505.ATUG01000001_gene3093 7.6e-10 59.7 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2MISZ@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Cytochrome c, bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_C7,Cytochrome_cB k59_182192_1 765912.Thimo_1303 8.09e-99 298.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_182192_2 765910.MARPU_04660 3.38e-140 403.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_182192_3 187272.Mlg_0929 2.39e-213 601.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_182192_4 1049564.TevJSym_ad01480 2.7e-95 284.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1J5U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1391,iSDY_1059.SDY_2348 Cytidylate_kin k59_182193_1 526225.Gobs_1207 2.45e-71 236.0 COG1523@1|root,COG1523@2|Bacteria 2|Bacteria G belongs to the glycosyl hydrolase 13 family - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48,PUD k59_188657_1 525268.HMPREF0308_0312 5.25e-15 75.9 COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,22JYC@1653|Corynebacteriaceae 201174|Actinobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_110874_1 316067.Geob_2314 9.23e-75 246.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,43TNJ@69541|Desulfuromonadales 28221|Deltaproteobacteria T histidine kinase, HAMP ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_65491_1 1121439.dsat_2153 4.14e-15 76.3 COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2M7VF@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM UvrD REP helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_52489_1 587753.EY04_03915 1.06e-48 190.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Membrane yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_195047_1 395493.BegalDRAFT_0038 8.31e-88 279.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,45ZT3@72273|Thiotrichales 72273|Thiotrichales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_201712_1 768671.ThimaDRAFT_0047 1.52e-47 172.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_7182_1 283942.IL2306 4.32e-12 65.1 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,2QF55@267893|Idiomarinaceae 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3734,iSBO_1134.SBO_4018 URO-D k59_7182_2 1049564.TevJSym_at00060 3.01e-123 361.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_7182_3 886293.Sinac_0727 2.81e-107 334.0 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - 3.2.1.123 ko:K05991 - - - - ko00000,ko01000 - GH5 - Cellulase k59_136785_2 388401.RB2150_15371 9.24e-38 137.0 COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,2UC68@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Tail Collar - - - - - - - - - - - - Collar k59_136785_3 1049564.TevJSym_af00620 1.18e-74 239.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1J4UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_39497_1 207954.MED92_18058 2.26e-63 208.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,1RPAT@1236|Gammaproteobacteria,1XHZS@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1 k59_39497_2 1049564.TevJSym_aa02270 3.24e-157 447.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1J536@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0040011,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_20065_5 1234679.BN424_1840 1.83e-45 184.0 COG3064@1|root,COG3953@1|root,COG3064@2|Bacteria,COG3953@2|Bacteria 2|Bacteria M translation initiation factor activity - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k59_20065_15 261292.Nit79A3_1308 2.26e-53 182.0 COG4870@1|root,COG4870@2|Bacteria,1MV6S@1224|Proteobacteria 1224|Proteobacteria O cysteine protease - - - - - - - - - - - - Peptidase_C1 k59_20065_20 997296.PB1_16219 1.08e-20 89.7 29Z0F@1|root,30KXJ@2|Bacteria,1UB2E@1239|Firmicutes,4I24F@91061|Bacilli,1ZK0T@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_46179_1 1121405.dsmv_1752 4.03e-30 117.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42QB5@68525|delta/epsilon subdivisions,2WMMA@28221|Deltaproteobacteria,2MQ1A@213118|Desulfobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_13744_1 1049564.TevJSym_ac00940 1.85e-290 816.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1J4SW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_156461_2 335541.Swol_0796 1.15e-24 102.0 COG3058@1|root,COG3058@2|Bacteria,1VJXM@1239|Firmicutes,25DK9@186801|Clostridia,42KN0@68298|Syntrophomonadaceae 186801|Clostridia C Necessary for formate dehydrogenase activity - - - ko:K02380 - - - - ko00000 - - - FdhE k59_150070_1 631362.Thi970DRAFT_04876 5.68e-107 318.0 COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RZ6E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM TIGR00266 family protein - - - - - - - - - - - - AIM24 k59_150070_2 338966.Ppro_3114 4.32e-13 68.9 COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,42WF3@68525|delta/epsilon subdivisions,2WS14@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF533) - - - - - - - - - - - - DUF533 k59_195211_2 1380346.JNIH01000064_gene5212 1.36e-05 49.3 COG5301@1|root,COG5301@2|Bacteria,2ISHQ@201174|Actinobacteria 201174|Actinobacteria G cellulose 1,4-beta-cellobiosidase activity - - - - - - - - - - - - - k59_201931_1 196367.JNFG01000037_gene7588 6.87e-20 90.1 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K1DV@119060|Burkholderiaceae 28216|Betaproteobacteria MU TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_201931_2 1121396.KB893063_gene1210 1.66e-41 152.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales 28221|Deltaproteobacteria V Hydrophobe Amphiphile Efflux-1 (HAE1) Family bepE - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_169452_1 1499967.BAYZ01000074_gene2123 1.77e-51 178.0 COG0438@1|root,COG0438@2|Bacteria,2NQHY@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1,Glycos_transf_2 k59_137017_1 1049564.TevJSym_aa02130 3.01e-23 97.4 2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - MotA_ExbB k59_78879_1 1232437.KL661961_gene2972 2.04e-73 228.0 COG0005@1|root,COG0005@2|Bacteria,1R7BS@1224|Proteobacteria,42ZMM@68525|delta/epsilon subdivisions,2WUWV@28221|Deltaproteobacteria,2MPH3@213118|Desulfobacterales 28221|Deltaproteobacteria F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate deoD - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_79888_14 159087.Daro_2605 0.0 1017.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales 206389|Rhodocyclales C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_79888_15 349966.DJ58_2509 1.03e-11 72.8 COG5557@1|root,COG5557@2|Bacteria,1MWXD@1224|Proteobacteria,1S0B0@1236|Gammaproteobacteria,41FUE@629|Yersinia 1236|Gammaproteobacteria C Polysulphide reductase, NrfD ttrC - - ko:K08359 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - NrfD k59_79888_16 85643.Tmz1t_0385 1.36e-98 294.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VK6R@28216|Betaproteobacteria,2KVYG@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11,Fer4_4 k59_112148_1 887929.HMP0721_1340 8.29e-18 84.0 COG0398@1|root,COG0398@2|Bacteria,1V7NH@1239|Firmicutes,24HNU@186801|Clostridia,25WRN@186806|Eubacteriaceae 186801|Clostridia S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_8384_1 768671.ThimaDRAFT_0545 8.36e-176 515.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WWA1@135613|Chromatiales 135613|Chromatiales C aconitate hydratase - - 4.2.1.117 ko:K20455 ko00640,map00640 - R11263 RC01152 ko00000,ko00001,ko01000 - - - Aconitase,Aconitase_C k59_27834_2 1249627.D779_3015 4.74e-47 158.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria,1WZMS@135613|Chromatiales 135613|Chromatiales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_66557_1 1397527.Q670_11950 4.42e-30 115.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_66557_2 765912.Thimo_0558 8.85e-91 272.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales 135613|Chromatiales I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_66557_3 765912.Thimo_0559 8.76e-51 163.0 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1WYI8@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_189950_1 765913.ThidrDRAFT_3777 3.87e-158 450.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RPAX@1236|Gammaproteobacteria,1WZVR@135613|Chromatiales 135613|Chromatiales C Belongs to the LDH MDH superfamily. LDH family ldh - 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N k59_34358_1 933262.AXAM01000049_gene3259 1.33e-95 293.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_8388_1 870187.Thini_0288 9.43e-48 162.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,460TW@72273|Thiotrichales 72273|Thiotrichales S High frequency lysogenization protein hflD homolog hflD - - ko:K07153 - - - - ko00000 - - - DUF489 k59_202890_2 395495.Lcho_0079 0.0 876.0 COG4670@1|root,COG4670@2|Bacteria,1MX9F@1224|Proteobacteria,2VJU4@28216|Betaproteobacteria,1KKCA@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Malonate decarboxylase, alpha subunit, transporter mdcA - 2.3.1.187 ko:K13929 - - R08944 RC00012,RC00014 ko00000,ko01000,ko02000 3.B.1.1.4 - - Mal_decarbox_Al k59_125278_1 1117315.AHCA01000010_gene997 2.55e-154 444.0 COG3119@1|root,COG3119@2|Bacteria,1P73G@1224|Proteobacteria,1RYE9@1236|Gammaproteobacteria,2Q4SR@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P PFAM sulfatase - - - - - - - - - - - - DUF4994,Sulfatase,Sulfatase_C k59_53609_1 945543.VIBR0546_09474 8.36e-70 233.0 COG0582@1|root,COG0582@2|Bacteria,1R43H@1224|Proteobacteria,1RNI0@1236|Gammaproteobacteria,1Y2DP@135623|Vibrionales 135623|Vibrionales L Arm DNA-binding domain VP0380 - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_53609_2 225937.HP15_1434 2.27e-32 116.0 28VZK@1|root,2ZI0S@2|Bacteria,1P618@1224|Proteobacteria,1STA9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_53609_6 1209072.ALBT01000058_gene828 5.63e-64 202.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1FH39@10|Cellvibrio 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_53609_7 172088.AUGA01000071_gene7565 1.27e-07 51.2 2AHDU@1|root,317QW@2|Bacteria,1N5TG@1224|Proteobacteria 1224|Proteobacteria S Prophage CP4-57 regulatory protein (AlpA) - - - - - - - - - - - - Phage_AlpA k59_131770_1 439235.Dalk_3943 4.46e-145 444.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2MJ8R@213118|Desulfobacterales 28221|Deltaproteobacteria CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_137763_1 338969.Rfer_3870 3.05e-53 169.0 2BHIP@1|root,32BM3@2|Bacteria,1MZJ9@1224|Proteobacteria,2WFDP@28216|Betaproteobacteria 28216|Betaproteobacteria S Ethyl tert-butyl ether degradation - - - - - - - - - - - - EthD k59_137763_2 1248232.BANQ01000155_gene4184 2.37e-76 235.0 2D3H4@1|root,32TEZ@2|Bacteria,1MYWS@1224|Proteobacteria,1S858@1236|Gammaproteobacteria,1Y04F@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_137763_3 1049564.TevJSym_ag00710 1.14e-22 93.6 COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1S1T3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG k59_8390_1 160492.XF_1583 0.000949 41.2 2DBB8@1|root,2Z867@2|Bacteria,1NDFK@1224|Proteobacteria,1S055@1236|Gammaproteobacteria,1X65Y@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3383) - - - - - - - - - - - - DUF3383 k59_27840_1 1134474.O59_000935 6.79e-68 233.0 COG2730@1|root,COG3533@1|root,COG2730@2|Bacteria,COG3533@2|Bacteria,1R6KS@1224|Proteobacteria,1RWE9@1236|Gammaproteobacteria,1FHZG@10|Cellvibrio 1236|Gammaproteobacteria G CBD_II - - - - - - - - - - - - CBM_2 k59_1647_1 1265505.ATUG01000001_gene4512 2.17e-134 389.0 COG0462@1|root,COG0462@2|Bacteria,1R2XV@1224|Proteobacteria,42MD5@68525|delta/epsilon subdivisions,2WK1E@28221|Deltaproteobacteria,2MHPM@213118|Desulfobacterales 28221|Deltaproteobacteria EF Phosphoribosyl synthetase-associated domain - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_34364_1 880072.Desac_0487 9.3e-57 180.0 2DWSR@1|root,341Q6@2|Bacteria,1Q538@1224|Proteobacteria,430G3@68525|delta/epsilon subdivisions,2WVK2@28221|Deltaproteobacteria,2MRYW@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_21497_1 159087.Daro_2728 1.01e-20 94.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KV7D@206389|Rhodocyclales 206389|Rhodocyclales NT Cache_2 - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_2,sCache_2 k59_53613_1 690850.Desaf_3493 1.17e-40 155.0 2E2CM@1|root,32XHK@2|Bacteria,1PZ5F@1224|Proteobacteria,435QW@68525|delta/epsilon subdivisions,2X9C3@28221|Deltaproteobacteria,2MAMB@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_99015_1 335543.Sfum_3311 3.47e-67 216.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2MQ83@213462|Syntrophobacterales 28221|Deltaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_73171_1 1049564.TevJSym_bj00200 3.01e-25 103.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1J9PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1786_1 1142394.PSMK_26780 4.04e-24 107.0 COG0589@1|root,COG1808@1|root,COG0589@2|Bacteria,COG1808@2|Bacteria,2J3I1@203682|Planctomycetes 203682|Planctomycetes T Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_125482_1 1047013.AQSP01000091_gene642 2.81e-103 333.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain sfrB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944 1.12.1.3,1.17.1.10,1.6.5.3 ko:K00335,ko:K15022,ko:K18331 ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200 M00144,M00377 R00134,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_2080 2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB k59_112299_1 1116472.MGMO_3c00040 8.93e-39 140.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XFDE@135618|Methylococcales 135618|Methylococcales L PFAM RNA-directed DNA polymerase (reverse transcriptase) - - - - - - - - - - - - GIIM,RVT_1 k59_60401_1 1121441.AUCX01000016_gene2363 7.38e-26 114.0 COG2202@1|root,COG2984@1|root,COG3852@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,42NXV@68525|delta/epsilon subdivisions,2X6Z9@28221|Deltaproteobacteria,2MH91@213115|Desulfovibrionales 28221|Deltaproteobacteria T signal transduction histidine kinase - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3 k59_119021_1 760568.Desku_2045 5.46e-07 50.8 COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,24A2N@186801|Clostridia,261YJ@186807|Peptococcaceae 186801|Clostridia T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_119021_2 1242864.D187_008898 1.11e-24 104.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family hsfA - - ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_8577_1 2340.JV46_16620 9.03e-35 134.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SBMS@1236|Gammaproteobacteria,1JBHM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_183921_3 666681.M301_1907 1.21e-35 134.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VN53@28216|Betaproteobacteria,2KM14@206350|Nitrosomonadales 206350|Nitrosomonadales I PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding k59_131980_1 1232683.ADIMK_0778 3.56e-198 567.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,46DB9@72275|Alteromonadaceae 1236|Gammaproteobacteria T V4R - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - GAF_2,GGDEF,HTH_8,Sigma54_activat,V4R,XylR_N k59_105631_1 316067.Geob_2758 5.34e-96 293.0 COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,42R90@68525|delta/epsilon subdivisions,2WMUJ@28221|Deltaproteobacteria,43SZC@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-2 - - - - - - - - - - - MS_channel k59_86343_1 335543.Sfum_1970 6.88e-116 338.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MQGV@213462|Syntrophobacterales 28221|Deltaproteobacteria C Oxidoreductase NAD-binding domain hdrF - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_151289_1 75379.Tint_3087 2.62e-22 95.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KKE0@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Sigma-54 interaction domain hoxA - - ko:K19641 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_151289_2 1123399.AQVE01000006_gene3553 1.51e-124 364.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,460EX@72273|Thiotrichales 72273|Thiotrichales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_196148_1 880072.Desac_0311 1.36e-99 319.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Pyr_redox_2 k59_196152_1 330214.NIDE1251 3.95e-32 117.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_14635_1 497321.C664_11570 1.05e-42 148.0 COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2VID0@28216|Betaproteobacteria,2KY10@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_14635_4 1049564.TevJSym_af00270 2.72e-61 192.0 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_14635_5 1454004.AW11_03688 3.92e-37 131.0 COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2VVUF@28216|Betaproteobacteria 28216|Betaproteobacteria V Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_14635_6 1049564.TevJSym_af00290 3.7e-119 345.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1J4XN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_14635_7 572477.Alvin_1133 6.44e-250 697.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1WWJT@135613|Chromatiales 135613|Chromatiales H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_93090_2 177437.HRM2_43710 1.67e-28 107.0 COG3436@1|root,COG3436@2|Bacteria,1MYCD@1224|Proteobacteria,42TEE@68525|delta/epsilon subdivisions,2WPUG@28221|Deltaproteobacteria,2MPR3@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_164050_1 1056820.KB900699_gene1347 2.65e-95 316.0 COG0663@1|root,COG2273@1|root,COG3507@1|root,COG0663@2|Bacteria,COG2273@2|Bacteria,COG3507@2|Bacteria,1Q0SI@1224|Proteobacteria,1S04W@1236|Gammaproteobacteria,2PPK5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Carbohydrate binding module (family 35) - - - - - - - - - - - - CBM_2 k59_164050_2 33876.JNXY01000001_gene6079 3.31e-185 536.0 2DP8S@1|root,3311S@2|Bacteria,2IBQV@201174|Actinobacteria,4D9ZS@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_196174_1 1049564.TevJSym_av00260 1.13e-59 198.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_14650_1 1049564.TevJSym_bb00110 3.16e-207 580.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1J4ZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the citrate synthase family gltA GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_00727 Citrate_synt k59_14650_2 870187.Thini_0278 5.85e-69 222.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,4637B@72273|Thiotrichales 72273|Thiotrichales C Fe-S oxidoreductase - - - - - - - - - - - - CCG,Fer4_8 k59_66739_2 1049564.TevJSym_ab01380 1.94e-41 148.0 COG2885@1|root,COG2885@2|Bacteria,1RIG3@1224|Proteobacteria,1S5WW@1236|Gammaproteobacteria,1JAQP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF4398,OmpA k59_21735_1 1049564.TevJSym_bt00090 7.47e-109 328.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1S7I9@1236|Gammaproteobacteria,1JBVR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain VPA0559 - - - - - - - - - - - FtsX,MacB_PCD k59_21735_3 1049564.TevJSym_bt00070 2.41e-89 267.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1J5S9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030163,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0052689,GO:0071704,GO:0140098,GO:0140101,GO:1901564,GO:1901565,GO:1901575 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_21735_4 2340.JV46_16220 3.37e-74 230.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1J5QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_80071_2 870187.Thini_3302 4.72e-49 162.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,46090@72273|Thiotrichales 72273|Thiotrichales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_73185_1 1195246.AGRI_06457 4.96e-14 77.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,4643B@72275|Alteromonadaceae 1236|Gammaproteobacteria O peptidylprolyl isomerase ppiD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_164051_1 1565129.JSFF01000017_gene2879 2.96e-154 454.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,2Q92G@267890|Shewanellaceae 1236|Gammaproteobacteria P Citrate transporter nhaD - - - - - - - - - - - CitMHS k59_144918_1 604331.AUHY01000048_gene2130 3.79e-05 47.8 COG0517@1|root,COG0517@2|Bacteria,1WMQJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Domain in cystathionine beta-synthase and other proteins. - - - ko:K04767 - - - - ko00000 - - - CBS k59_86355_2 1056820.KB900643_gene824 4.66e-107 372.0 COG2885@1|root,COG4547@1|root,COG5384@1|root,COG2885@2|Bacteria,COG4547@2|Bacteria,COG5384@2|Bacteria,1MX1F@1224|Proteobacteria,1RYU1@1236|Gammaproteobacteria,2PNMF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria HJM Cadherin repeats. - - - - - - - - - - - - Cadherin_3,DUF4347,OmpA k59_28001_2 857087.Metme_3213 2.73e-19 85.5 2EK1K@1|root,33DS2@2|Bacteria,1NI6I@1224|Proteobacteria,1SH8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_28001_3 986075.CathTA2_0592 1.21e-13 72.4 COG0624@1|root,COG0624@2|Bacteria,1TQ0P@1239|Firmicutes,4HAE4@91061|Bacilli 91061|Bacilli E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases amaB_2 - 3.5.3.9 ko:K02083 ko00230,ko01120,map00230,map01120 - R02423 RC00064 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_73186_1 1232437.KL661956_gene2429 4.03e-41 137.0 COG5561@1|root,COG5561@2|Bacteria,1RH81@1224|Proteobacteria,42SY4@68525|delta/epsilon subdivisions,2WPAG@28221|Deltaproteobacteria,2MK3G@213118|Desulfobacterales 28221|Deltaproteobacteria S CGGC - - - - - - - - - - - - CGGC k59_53769_1 285514.JNWO01000001_gene4728 1.67e-103 324.0 COG1609@1|root,COG1609@2|Bacteria,2GK7G@201174|Actinobacteria 201174|Actinobacteria K Rhodopirellula transposase DDE domain - - - - - - - - - - - - DDE_Tnp_ISAZ013,HTH_Tnp_4 k59_80080_1 1278309.KB907104_gene867 8.37e-57 184.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1XIIP@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the TrpC family trpC - 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_73188_1 933262.AXAM01000029_gene2755 2.48e-108 320.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MJCB@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_73188_2 1111479.AXAR01000003_gene1736 1.53e-07 52.4 COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,4HA6Q@91061|Bacilli,279W3@186823|Alicyclobacillaceae 91061|Bacilli D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_99027_1 933262.AXAM01000018_gene999 1.38e-109 328.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MIN7@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_159437_1 886293.Sinac_2199 1.51e-42 155.0 COG4584@1|root,COG4584@2|Bacteria,2J4C3@203682|Planctomycetes 203682|Planctomycetes L PFAM Integrase core domain - - - - - - - - - - - - rve k59_29656_1 314260.PB2503_12544 3.85e-33 117.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_121059_1 519989.ECTPHS_04324 2.76e-47 155.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales 135613|Chromatiales U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_185742_1 335543.Sfum_1711 2.49e-08 54.7 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MQ9T@213462|Syntrophobacterales 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_159443_1 296591.Bpro_1647 2.83e-05 50.4 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,2WG0X@28216|Betaproteobacteria 28216|Betaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_113913_1 307480.IW16_05735 6.5e-32 124.0 28PYV@1|root,2ZCIC@2|Bacteria,4PE6Y@976|Bacteroidetes,1IEPQ@117743|Flavobacteriia,3ZPHK@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_49199_1 1460635.JCM19038_1766 1.34e-05 47.4 COG0425@1|root,COG0607@1|root,COG0425@2|Bacteria,COG0607@2|Bacteria,1V1GU@1239|Firmicutes,4HFR8@91061|Bacilli 91061|Bacilli OP Belongs to the sulfur carrier protein TusA family yrkF - - - - - - - - - - - Rhodanese,TusA k59_49199_2 177437.HRM2_46820 1.03e-48 166.0 COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,2MJ8M@213118|Desulfobacterales 28221|Deltaproteobacteria P Rubrerythrin - - - - - - - - - - - - Rhodanese,Rubrerythrin k59_152774_1 795666.MW7_2391 5.75e-52 174.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,1JZPC@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR family oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_10423_1 1121918.ARWE01000001_gene1254 6.34e-60 201.0 COG0084@1|root,COG0535@1|root,COG0084@2|Bacteria,COG0535@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,43S50@69541|Desulfuromonadales 28221|Deltaproteobacteria L TatD related DNase tatD - - ko:K03424 - - - - ko00000,ko01000 - - - Fer4_14,Radical_SAM,TatD_DNase k59_29661_1 43759.JNWK01000026_gene6972 1.03e-11 69.3 COG1032@1|root,COG1032@2|Bacteria,2I8XZ@201174|Actinobacteria 201174|Actinobacteria C Radical SAM - - - ko:K18564 ko00332,ko01130,map00332,map01130 - R10738 RC03266 ko00000,ko00001,ko01000 - - - B12-binding,Radical_SAM k59_127713_1 288000.BBta_1460 2.43e-113 345.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_87995_1 1192868.CAIU01000013_gene1558 4.61e-48 174.0 COG0491@1|root,COG1116@1|root,COG0491@2|Bacteria,COG1116@2|Bacteria,1MX4H@1224|Proteobacteria,2TR8F@28211|Alphaproteobacteria,43JA3@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_139571_2 765911.Thivi_3392 6.65e-77 245.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_159447_1 1049564.TevJSym_ap00460 1.24e-51 177.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_159447_2 1049564.TevJSym_ap00450 2.2e-09 57.4 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_107574_3 1123392.AQWL01000003_gene322 1.14e-119 369.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales 119069|Hydrogenophilales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_107574_4 1492737.FEM08_22380 1e-32 123.0 COG3952@1|root,COG3952@2|Bacteria,4NH8Q@976|Bacteroidetes,1HYST@117743|Flavobacteriia 976|Bacteroidetes S PFAM lipid A biosynthesis - - - - - - - - - - - - LAB_N k59_3278_1 933262.AXAM01000077_gene1704 4.54e-128 381.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,43BR1@68525|delta/epsilon subdivisions,2WIIS@28221|Deltaproteobacteria,2MIQ9@213118|Desulfobacterales 28221|Deltaproteobacteria P Catalyzes the synthesis of activated sulfate cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_49201_1 765913.ThidrDRAFT_2226 1.02e-69 222.0 COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,1RSB2@1236|Gammaproteobacteria,1WX39@135613|Chromatiales 135613|Chromatiales O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureD - - ko:K03190 - - - - ko00000 - - - UreD k59_55170_1 545264.KB898749_gene79 2.66e-64 198.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales 135613|Chromatiales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_55170_2 1049564.TevJSym_ar00210 5.1e-198 557.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1J4X2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Nucleoside H+ symporter hcaT - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_55170_3 349521.HCH_02421 1.22e-69 221.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XHJ7@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_10426_1 983545.Glaag_3267 2.82e-71 224.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,464H5@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_100657_1 335543.Sfum_1380 3.75e-161 461.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MQ94@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_121273_1 1278307.KB906971_gene1451 1.43e-05 46.6 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RNDN@1236|Gammaproteobacteria,2QIER@267894|Psychromonadaceae 1236|Gammaproteobacteria EK Alanine-glyoxylate amino-transferase lysN - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_121273_2 525373.HMPREF0766_14268 8.22e-23 101.0 COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,1IP66@117747|Sphingobacteriia 976|Bacteroidetes Q Methylase involved in ubiquinone menaquinone biosynthesis arsM - 2.1.1.137,2.1.1.79 ko:K00574,ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 k59_121273_3 1524467.IV04_08050 2.66e-10 60.1 COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,1S2EZ@1236|Gammaproteobacteria,3ZZWG@613|Serratia 1236|Gammaproteobacteria S phenazine biosynthesis protein yddE - - - - - - - - - - - PhzC-PhzF k59_81900_1 1088721.NSU_4947 3.38e-108 321.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,2K3CJ@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_10613_1 335543.Sfum_1218 1.6e-100 306.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MQ61@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_185962_1 66429.JOFL01000003_gene3204 4.65e-38 138.0 COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_121275_1 338963.Pcar_1232 3.38e-26 113.0 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,43SCT@69541|Desulfuromonadales 28221|Deltaproteobacteria S 7TM-HD extracellular - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_100820_1 1049564.TevJSym_by00040 7.06e-52 168.0 COG2888@1|root,COG2888@2|Bacteria,1PBSM@1224|Proteobacteria,1SWH0@1236|Gammaproteobacteria,1JBN5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Zinc-ribbon containing domain - - - - - - - - - - - - DUF1451 k59_100820_2 580340.Tlie_0667 8.64e-59 199.0 COG0563@1|root,COG0563@2|Bacteria,3TA8N@508458|Synergistetes 508458|Synergistetes F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_114040_1 394503.Ccel_2977 9.15e-139 400.0 COG2801@1|root,COG2801@2|Bacteria,1V8EJ@1239|Firmicutes,24MA4@186801|Clostridia,36HTH@31979|Clostridiaceae 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,HTH_8,rve k59_16423_1 1265505.ATUG01000002_gene2120 3.2e-84 276.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,2MHVS@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-2 - - - - - - - - - - - MS_channel k59_185965_1 880073.Calab_2026 1.4e-104 318.0 COG0696@1|root,COG0696@2|Bacteria,2NP1Y@2323|unclassified Bacteria 2|Bacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_172356_2 1249627.D779_0410 3.86e-74 226.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1WY23@135613|Chromatiales 135613|Chromatiales I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_172356_3 1049564.TevJSym_au00540 1.39e-61 206.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_204801_1 1236542.BALM01000011_gene3910 3.32e-34 128.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,2Q93R@267890|Shewanellaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_43824_1 568817.SCc_626 4.22e-36 133.0 COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,1RPV0@1236|Gammaproteobacteria,400GN@613|Serratia 1236|Gammaproteobacteria U UPF0056 membrane protein yhgN GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_121281_1 1121472.AQWN01000001_gene96 8.53e-119 353.0 COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,260NX@186807|Peptococcaceae 186801|Clostridia E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_133820_1 1121468.AUBR01000078_gene859 2.64e-67 231.0 COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,25D02@186801|Clostridia,42FJ4@68295|Thermoanaerobacterales 186801|Clostridia L COGs COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,Mu-transpos_C,rve k59_133820_2 1121468.AUBR01000078_gene860 1.52e-41 150.0 COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia,42FBN@68295|Thermoanaerobacterales 186801|Clostridia L IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_185967_1 1121935.AQXX01000093_gene3438 6.14e-55 186.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1XHUS@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_185967_2 1158762.KB898037_gene2201 5.99e-35 129.0 COG3203@1|root,COG3203@2|Bacteria,1RF3Y@1224|Proteobacteria,1S5AQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_88181_1 946483.Cenrod_0064 3.01e-09 58.9 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VJIW@28216|Betaproteobacteria,4AB7Y@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - rve k59_88181_2 1562701.BBOF01000090_gene517 9.87e-27 106.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VMVE@28216|Betaproteobacteria,1K5SK@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_81918_1 879212.DespoDRAFT_00794 3.16e-13 66.6 COG2191@1|root,COG2191@2|Bacteria,1RBNI@1224|Proteobacteria,42QZP@68525|delta/epsilon subdivisions,2WMY0@28221|Deltaproteobacteria,2MJH4@213118|Desulfobacterales 28221|Deltaproteobacteria C FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - FmdE,zf-dskA_traR k59_81918_2 1232410.KI421416_gene2675 2.72e-30 110.0 COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_55353_1 1210884.HG799470_gene14318 4.19e-32 128.0 COG5659@1|root,COG5659@2|Bacteria,2IWRG@203682|Planctomycetes 203682|Planctomycetes L best DB hits BLAST gb AAD45539.1 - - - - - - - - - - - - DDE_5 k59_159680_1 1049564.TevJSym_ar00370 7.1e-65 209.0 COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,1SBMD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - - k59_159680_2 580332.Slit_1447 3.53e-64 219.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2WHYC@28216|Betaproteobacteria,44WNC@713636|Nitrosomonadales 1224|Proteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7 k59_95575_1 335543.Sfum_2092 6.52e-61 202.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRFD@213462|Syntrophobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_29837_1 395965.Msil_1741 6.56e-69 226.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N9VZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase type 2 domain - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_29837_3 1123366.TH3_02050 6.85e-48 161.0 COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,2TTJC@28211|Alphaproteobacteria,2JRAK@204441|Rhodospirillales 204441|Rhodospirillales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - ko:K13775 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short k59_74874_1 261292.Nit79A3_0304 6.92e-65 209.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2WEH1@28216|Betaproteobacteria,3746K@32003|Nitrosomonadales 28216|Betaproteobacteria L SMART ATPase, AAA type, core - - - - - - - - - - - - IstB_IS21 k59_23620_1 99598.Cal7507_3740 3.11e-103 325.0 COG4447@1|root,COG4447@2|Bacteria,1G5IX@1117|Cyanobacteria 1117|Cyanobacteria S cellulose binding - - - - - - - - - - - - Beta_helix,Peptidase_S74 k59_88182_1 237368.SCABRO_02856 1.62e-95 308.0 28NDD@1|root,2ZBG6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1 k59_107814_1 933262.AXAM01000015_gene101 4.14e-174 501.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_114054_2 493475.GARC_0404 1.74e-17 81.6 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680 PALP k59_133828_2 1049564.TevJSym_be00180 5.57e-73 224.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1J6Q8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_165811_1 335543.Sfum_0005 8.23e-29 120.0 COG0501@1|root,COG5010@1|root,COG0501@2|Bacteria,COG5010@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria 28221|Deltaproteobacteria O peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48,TPR_11,TPR_17 k59_121295_1 880072.Desac_0598 4.24e-48 167.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2MRC7@213462|Syntrophobacterales 28221|Deltaproteobacteria D Cell cycle protein ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_121295_2 309807.SRU_0558 2.76e-09 58.9 COG0771@1|root,COG0771@2|Bacteria,4NEFF@976|Bacteroidetes,1FITH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_100832_2 1049564.TevJSym_ac01560 4.48e-191 564.0 COG2114@1|root,COG2114@2|Bacteria,1NQPW@1224|Proteobacteria 1224|Proteobacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - - k59_29845_1 933262.AXAM01000031_gene3014 3.25e-60 205.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales 28221|Deltaproteobacteria D DNA segregation ATPase, FtsK SpoIIIE family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_81919_1 1250232.JQNJ01000001_gene2915 2.22e-27 111.0 COG4379@1|root,COG4379@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_36662_2 2340.JV46_14730 7.34e-123 363.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1J56S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - ko:K07082 - - - - ko00000 - - - YceG k59_36662_3 187272.Mlg_1418 1.24e-79 249.0 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_179176_1 316274.Haur_0335 4.1e-07 61.6 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2G67H@200795|Chloroflexi,374SX@32061|Chloroflexia 200795|Chloroflexi KLT Serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_179176_4 697282.Mettu_3792 1.7e-196 576.0 COG3540@1|root,COG3540@2|Bacteria,1MW0G@1224|Proteobacteria,1RP8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Isoleucyl-tRNA synthetase - - - - - - - - - - - - PhoD k59_139764_1 1313172.YM304_19620 3.57e-30 123.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CMWT@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase alpha chain like domain dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_152974_1 357804.Ping_0441 4.4e-193 552.0 COG1541@1|root,COG1541@2|Bacteria,1QA98@1224|Proteobacteria,1T9JJ@1236|Gammaproteobacteria,2QI3N@267894|Psychromonadaceae 1236|Gammaproteobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - - k59_172368_1 1121380.JNIW01000010_gene1219 4.69e-07 54.3 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - ko:K06149 - - - - ko00000 - - - Usp k59_130021_1 631362.Thi970DRAFT_02466 1.16e-112 330.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1WW0D@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_130021_2 1049564.TevJSym_ak00830 6.77e-52 170.0 COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1J70Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm lptA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065 OstA k59_130021_3 326297.Sama_3085 7.64e-11 65.9 COG3117@1|root,COG3117@2|Bacteria,1RA1Y@1224|Proteobacteria,1SDZE@1236|Gammaproteobacteria,2Q9I0@267890|Shewanellaceae 1236|Gammaproteobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA lptC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0017089,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - iB21_1397.B21_03015,iECBD_1354.ECBD_0543,iECB_1328.ECB_03064,iECD_1391.ECD_03064 LptC k59_130021_4 2340.JV46_29440 3.18e-49 162.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1J685@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate kdsC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECO26_1355.ECO26_4302 Hydrolase_3 k59_52180_3 1238450.VIBNISOn1_890023 1.76e-53 181.0 COG1715@1|root,COG1715@2|Bacteria 2|Bacteria V Restriction endonuclease - - - ko:K07448 - - - - ko00000,ko02048 - - - Mrr_cat,TerD k59_117028_1 261292.Nit79A3_2501 2.84e-90 277.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHC7@28216|Betaproteobacteria,374M1@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Integrase, catalytic core - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_117028_2 1191523.MROS_2323 5.97e-31 112.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_168847_1 1049564.TevJSym_cb00050 9.56e-68 226.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_130022_1 1042377.AFPJ01000019_gene2504 2.06e-46 162.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,465K9@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_201348_1 765912.Thimo_3116 1.76e-60 204.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1WX75@135613|Chromatiales 135613|Chromatiales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_201348_2 1049564.TevJSym_aj00360 5.47e-99 305.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1J4BW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_149435_1 322710.Avin_07240 1.69e-07 56.2 2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_123508_1 56780.SYN_01481 4.8e-48 173.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MQZ2@213462|Syntrophobacterales 28221|Deltaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_78243_1 279714.FuraDRAFT_2443 5.1e-34 134.0 COG4388@1|root,COG4388@2|Bacteria,1PVXP@1224|Proteobacteria,2VZ7Q@28216|Betaproteobacteria 28216|Betaproteobacteria S Mu-like prophage I protein - - - - - - - - - - - - Mu-like_Pro k59_149437_1 34506.g5626 5.57e-42 157.0 COG0351@1|root,COG1278@1|root,KOG2598@2759|Eukaryota,KOG3070@2759|Eukaryota,38DYW@33154|Opisthokonta,3BZJ7@33208|Metazoa,3DDBF@33213|Bilateria 33208|Metazoa HK Phosphomethylpyrimidine kinase - - - - - - - - - - - - Phos_pyr_kin,PseudoU_synth_2,RNase_HII,S4 k59_104010_1 316067.Geob_2698 9.94e-45 159.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,43TZJ@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM peptidase M16 domain protein - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_104010_2 340099.Teth39_1200 3.12e-07 51.2 COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,42GTP@68295|Thermoanaerobacterales 186801|Clostridia F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_110544_1 279238.Saro_2413 9.17e-18 87.8 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2TR28@28211|Alphaproteobacteria,2K11Y@204457|Sphingomonadales 204457|Sphingomonadales G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1 k59_149442_1 933262.AXAM01000036_gene2185 4.16e-128 377.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales 28221|Deltaproteobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_84620_1 404589.Anae109_1281 2.88e-48 175.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_123522_1 1157708.KB907461_gene1684 1.7e-22 102.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4AAAJ@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM CoA-binding domain protein - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_26291_1 1049564.TevJSym_ax00380 1.28e-59 197.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_32722_1 1121456.ATVA01000018_gene410 2.21e-14 73.9 COG0475@1|root,COG0475@2|Bacteria,1RFKE@1224|Proteobacteria,43B2P@68525|delta/epsilon subdivisions,2X6GM@28221|Deltaproteobacteria,2M9P0@213115|Desulfovibrionales 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_32722_2 1304872.JAGC01000003_gene3474 4.78e-52 184.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,42N23@68525|delta/epsilon subdivisions,2WKW2@28221|Deltaproteobacteria,2M7Z1@213115|Desulfovibrionales 28221|Deltaproteobacteria V ABC transporter, transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_175314_1 930169.B5T_00738 1.57e-05 47.4 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,1XIDY@135619|Oceanospirillales 135619|Oceanospirillales E branched-chain amino acid - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_123716_1 526222.Desal_0072 1.64e-06 49.7 COG2191@1|root,COG2191@2|Bacteria,1RFFR@1224|Proteobacteria,42T0H@68525|delta/epsilon subdivisions,2WNH3@28221|Deltaproteobacteria,2MBFF@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Formylmethanofuran dehydrogenase, subunit E region - - 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - FmdE,zf-dskA_traR k59_123716_2 1265505.ATUG01000001_gene3573 9.6e-101 312.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_26532_1 882.DVU_0535 7.31e-48 165.0 COG0437@1|root,COG3064@1|root,COG0437@2|Bacteria,COG3064@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2M9HU@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_26532_2 96561.Dole_2252 9.87e-75 235.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_182094_1 1894.JOER01000001_gene5156 1.07e-39 150.0 COG3845@1|root,COG3845@2|Bacteria,2I2Y2@201174|Actinobacteria 201174|Actinobacteria P ABC transporter, ATP-binding protein - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_182094_2 796940.HMPREF9628_01508 1.58e-05 47.0 COG4732@1|root,COG4732@2|Bacteria,1V6HH@1239|Firmicutes,24JF7@186801|Clostridia,25TR7@186804|Peptostreptococcaceae 186801|Clostridia S Thiamine-precursor transporter protein (ThiW) thiW - - - - - - - - - - - ThiW k59_65391_1 1121405.dsmv_1751 1.99e-85 264.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42N64@68525|delta/epsilon subdivisions,2WJ73@28221|Deltaproteobacteria,2MIX5@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_7110_1 172088.AUGA01000059_gene4246 4.27e-42 154.0 COG4995@1|root,COG4995@2|Bacteria,1R6PK@1224|Proteobacteria,2U09I@28211|Alphaproteobacteria,3JWPV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S TIR domain - - - - - - - - - - - - TIR_2 k59_201584_1 1165841.SULAR_02878 1.16e-20 92.8 COG3211@1|root,COG3211@2|Bacteria,1NSHF@1224|Proteobacteria 1224|Proteobacteria S Phosphatase - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_169074_1 1232437.KL662001_gene4594 1.02e-58 204.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MICU@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_162685_1 933262.AXAM01000127_gene1028 3.42e-88 271.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM AICARFT IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_182097_1 1049564.TevJSym_ac01400 1.6e-159 469.0 28N8G@1|root,2ZBCV@2|Bacteria,1NMB1@1224|Proteobacteria,1SMP0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_143150_1 95619.PM1_0203700 4.43e-21 88.6 2E3XG@1|root,32YUI@2|Bacteria,1N8RF@1224|Proteobacteria,1SCJ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a - - - - - - - - - - - - PilZ k59_39416_1 56780.SYN_01191 2.75e-88 273.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MQY6@213462|Syntrophobacterales 28221|Deltaproteobacteria KT PFAM Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_175551_1 883126.HMPREF9710_04822 1.72e-76 238.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_32,rve,rve_3 k59_58962_1 574375.BAGA_11250 1.05e-41 145.0 COG2249@1|root,COG2249@2|Bacteria,1V8BU@1239|Firmicutes,4IQSZ@91061|Bacilli,1ZRNE@1386|Bacillus 91061|Bacilli S NAD(P)H dehydrogenase - - 1.6.5.2 ko:K00355 ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - Flavodoxin_2 k59_97745_1 870187.Thini_3017 2.1e-109 327.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,4609E@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_97745_2 1049564.TevJSym_bl00220 1.1e-110 340.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_583_1 228410.NE0621 6.69e-41 136.0 COG1359@1|root,COG1359@2|Bacteria,1PVN1@1224|Proteobacteria,2W4K2@28216|Betaproteobacteria,373DC@32003|Nitrosomonadales 28216|Betaproteobacteria C Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_149697_2 1049564.TevJSym_be00230 6.56e-56 177.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1SCFP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_149697_4 1049564.TevJSym_av00040 2.33e-284 788.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_32947_2 1049564.TevJSym_ag00510 2.81e-114 335.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_91302_1 349521.HCH_00777 5.34e-68 221.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RQ07@1236|Gammaproteobacteria,1XI0Z@135619|Oceanospirillales 135619|Oceanospirillales C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_20029_1 1049564.TevJSym_bc00200 9e-06 47.4 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1J5UI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c13120,ic_1306.c1370 Thymidylate_kin k59_20029_2 1166948.JPZL01000001_gene2378 3.79e-64 213.0 COG0470@1|root,COG0470@2|Bacteria,1R9U1@1224|Proteobacteria,1T1C8@1236|Gammaproteobacteria,1XRRK@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III, delta subunit, C terminal - - - - - - - - - - - - DNA_pol3_delta2,DNApol3-delta_C k59_20029_3 1245471.PCA10_37850 3.42e-59 185.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1YG5E@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NU PilZ domain pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_20029_4 1049564.TevJSym_bc00230 8.32e-93 278.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1J4XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0084 Mg-dependent DNase ycfH GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_13488_2 314278.NB231_16028 1.16e-123 367.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1WWIB@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_13488_3 1049564.TevJSym_ac00840 8.75e-101 306.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1J54Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_65403_2 765910.MARPU_03780 2.31e-96 284.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales 135613|Chromatiales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_156151_1 1249627.D779_0025 4.52e-111 352.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1WXH7@135613|Chromatiales 135613|Chromatiales I SMART Phospholipid glycerol acyltransferase - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_194957_1 933262.AXAM01000008_gene1944 3.13e-102 308.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_91309_1 706587.Desti_0881 2.72e-34 125.0 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42SFW@68525|delta/epsilon subdivisions,2WPH3@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids cobA - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_78521_1 96561.Dole_0156 2.08e-101 305.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42M0D@68525|delta/epsilon subdivisions,2WK8T@28221|Deltaproteobacteria,2MJ65@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_130307_1 349521.HCH_06867 7.14e-110 350.0 COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,1RYVF@1236|Gammaproteobacteria,1XRXC@135619|Oceanospirillales 135619|Oceanospirillales S Putative exonuclease SbcCD, C subunit - - - - - - - - - - - - AAA_29,SbcCD_C k59_130307_2 1209072.ALBT01000011_gene3152 1.19e-33 125.0 28P60@1|root,2ZC0V@2|Bacteria,1RC8V@1224|Proteobacteria,1S29Y@1236|Gammaproteobacteria,1FGYY@10|Cellvibrio 1236|Gammaproteobacteria S Domain of unknown function (DUF4194) - - - - - - - - - - - - DUF4194 k59_13497_1 314285.KT71_13350 1.84e-44 161.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1,Thioredoxin_4 k59_20033_1 335543.Sfum_2807 1.12e-46 173.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_9,Response_reg k59_182110_1 693661.Arcve_1359 8.98e-13 73.9 COG3291@1|root,COG3979@1|root,arCOG02499@1|root,arCOG02552@1|root,arCOG03439@1|root,arCOG02499@2157|Archaea,arCOG02552@2157|Archaea,arCOG03439@2157|Archaea,arCOG03504@2157|Archaea,arCOG07581@2157|Archaea,2XXWR@28890|Euryarchaeota 28890|Euryarchaeota P PFAM periplasmic copper-binding - - - - - - - - - - - - Beta_helix,NosD,PKD k59_7116_1 335543.Sfum_0536 8.2e-47 157.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MQEG@213462|Syntrophobacterales 28221|Deltaproteobacteria U TIGRFAM signal peptidase I lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_136709_1 1121405.dsmv_2307 2.48e-106 320.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MJ57@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_52433_1 765912.Thimo_1749 3.62e-69 221.0 28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria,1WX53@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_169107_1 272630.MexAM1_META1p3482 8.73e-09 59.3 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2UPJD@28211|Alphaproteobacteria,1JQYZ@119045|Methylobacteriaceae 28211|Alphaproteobacteria K PFAM regulatory protein LuxR - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_194960_1 1049564.TevJSym_ao00020 1.39e-183 521.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1J4IU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases visC - - ko:K03184,ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R06146,R08768,R08773,R08775 RC00046,RC01254,RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3,SE k59_20039_1 1288494.EBAPG3_30370 1.07e-37 139.0 COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2WAXX@28216|Betaproteobacteria,371M6@32003|Nitrosomonadales 28216|Betaproteobacteria C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_162701_1 1479235.KK366039_gene1179 1.82e-84 270.0 COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,1RMHC@1236|Gammaproteobacteria,1XIHV@135619|Oceanospirillales 135619|Oceanospirillales EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_4 k59_162701_2 207954.MED92_11024 1.8e-84 261.0 COG0583@1|root,COG0583@2|Bacteria,1N8HZ@1224|Proteobacteria,1RR4Z@1236|Gammaproteobacteria,1XJA7@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_188571_2 521098.Aaci_2770 8.65e-12 65.1 COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,4HKBQ@91061|Bacilli,27AE4@186823|Alicyclobacillaceae 91061|Bacilli T low molecular weight ywlE - 3.1.3.48,3.9.1.2 ko:K01104,ko:K20201 - - - - ko00000,ko01000 - - - LMWPc k59_7123_1 439235.Dalk_1918 7.67e-77 232.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2WNFM@28221|Deltaproteobacteria,2MJJG@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_7123_2 338963.Pcar_0698 3.2e-110 337.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,43S77@69541|Desulfuromonadales 28221|Deltaproteobacteria J Elongation factor G, domain IV fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_32976_1 385682.AFSL01000063_gene1561 3.68e-32 128.0 COG3014@1|root,COG3014@2|Bacteria,4NIIU@976|Bacteroidetes,2FQVB@200643|Bacteroidia,3XJT4@558415|Marinilabiliaceae 976|Bacteroidetes S Tetratricopeptide repeat - - - ko:K09859 - - - - ko00000 - - - TPR_2 k59_610_1 670487.Ocepr_0567 1.38e-68 233.0 COG2217@1|root,COG2217@2|Bacteria,1WJ55@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P ATPase P-type (Transporting), HAD superfamily, subfamily IC pacS - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_136722_1 1049564.TevJSym_ar00480 3.24e-107 315.0 COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1J6J0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_136722_2 1049564.TevJSym_ar00470 1.08e-157 461.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_84858_2 1049564.TevJSym_aa02190 1.51e-83 252.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria 1236|Gammaproteobacteria G PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - - - - - - - - - - Pro_isomerase k59_53462_1 1049564.TevJSym_ad01660 5.94e-162 471.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_53462_2 395493.BegalDRAFT_2462 1.58e-52 171.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 - ko:K02197 - - - - ko00000 - - iSSON_1240.SSON_2255 CcmE k59_53462_3 767434.Fraau_1055 7.89e-06 45.8 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1X8T1@135614|Xanthomonadales 135614|Xanthomonadales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - - CcmD k59_53462_4 1049564.TevJSym_ad01690 7.92e-24 96.7 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1J54R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm k59_66404_1 439235.Dalk_0888 1.02e-131 390.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MIZ1@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Starch synthase catalytic - - 2.4.1.21,3.2.1.1 ko:K00703,ko:K01176 ko00500,ko01100,ko01110,ko02026,ko04973,map00500,map01100,map01110,map02026,map04973 M00565 R02108,R02112,R02421,R11262 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GH13,GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_118577_1 702459.BBPR_0264 0.000233 53.5 COG0366@1|root,COG1196@1|root,COG0366@2|Bacteria,COG1196@2|Bacteria,2I615@201174|Actinobacteria,4CZVH@85004|Bifidobacteriales 201174|Actinobacteria G Glycosyl hydrolase 101 beta sandwich domain - - 3.2.1.97 ko:K17624 - - - - ko00000,ko01000 - GH101 - CarboxypepD_reg,F5_F8_type_C,FIVAR,Glyco_hyd_101C,Glyco_hydro_101 k59_118577_2 765912.Thimo_1917 8.63e-234 662.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1WVZE@135613|Chromatiales 135613|Chromatiales G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_125042_1 933262.AXAM01000034_gene1564 2.45e-33 129.0 28MH4@1|root,2ZAU2@2|Bacteria,1P8YP@1224|Proteobacteria,42MQK@68525|delta/epsilon subdivisions,2WKCY@28221|Deltaproteobacteria,2MJ4Z@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_27639_2 1219077.VAZ01S_122_00010 1.73e-78 238.0 28VHE@1|root,2ZHJV@2|Bacteria 2|Bacteria S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_40775_1 1244869.H261_12381 6.22e-23 96.7 COG0407@1|root,COG0407@2|Bacteria,1R9IN@1224|Proteobacteria 1224|Proteobacteria H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_40775_2 1232410.KI421424_gene1693 7.3e-100 295.0 COG5012@1|root,COG5012@2|Bacteria,1PXID@1224|Proteobacteria,42R7Q@68525|delta/epsilon subdivisions,2WN2K@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Methionine synthase B12-binding module cap domain protein - - - - - - - - - - - - B12-binding,B12-binding_2 k59_183443_1 643562.Daes_1765 1.67e-27 107.0 COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2M96M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 k59_183443_2 880073.Calab_2026 3.09e-108 327.0 COG0696@1|root,COG0696@2|Bacteria,2NP1Y@2323|unclassified Bacteria 2|Bacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_125044_1 224915.bbp_141 2.81e-12 71.6 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,37D2S@32199|Buchnera 1236|Gammaproteobacteria A ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_60094_1 1408433.JHXV01000007_gene2985 2.77e-71 233.0 COG3039@1|root,COG3039@2|Bacteria,4PKH0@976|Bacteroidetes 976|Bacteroidetes L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_163771_1 1049564.TevJSym_aj00510 5.32e-80 251.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1J6D6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter nhaD - - - - - - - - - - - CitMHS k59_27641_1 879212.DespoDRAFT_02343 4.66e-61 212.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS k59_34173_1 1449049.JONW01000013_gene4674 6.79e-06 48.5 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,2UC9Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Transcriptional regulator, ModE family mopB - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE k59_34173_2 1049564.TevJSym_bi00100 1.09e-126 374.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1J56U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 AA_kinase,Acetyltransf_1 k59_40778_1 765912.Thimo_1744 2.31e-06 49.3 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_40778_2 666681.M301_1847 2.02e-43 151.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2VN9Y@28216|Betaproteobacteria 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_21254_1 1121405.dsmv_2738 1.57e-88 281.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_118587_1 1121116.KB894765_gene686 2.06e-16 84.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,4AA94@80864|Comamonadaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_92590_1 314230.DSM3645_17685 1.18e-111 332.0 COG0039@1|root,COG0039@2|Bacteria,2IY7S@203682|Planctomycetes 203682|Planctomycetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_195810_2 395494.Galf_2621 6.2e-72 223.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria 28216|Betaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_66413_1 1232437.KL662038_gene2303 3.04e-76 249.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MHNT@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_144502_1 1049564.TevJSym_ah00130 3.67e-86 262.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1J583@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_144502_2 765912.Thimo_2449 3.48e-100 298.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales 135613|Chromatiales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_183451_1 1123377.AUIV01000022_gene1982 2.16e-15 75.1 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S1QJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_170487_1 1121405.dsmv_2046 3.61e-42 157.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_40783_1 1049564.TevJSym_ai00970 3.25e-223 635.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_27868_3 335543.Sfum_0110 1.95e-14 73.6 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2MQH0@213462|Syntrophobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_131810_1 1121403.AUCV01000040_gene4324 1.73e-88 290.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2MJ8R@213118|Desulfobacterales 28221|Deltaproteobacteria CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_190003_1 998674.ATTE01000001_gene4288 1.7e-80 240.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,460I6@72273|Thiotrichales 72273|Thiotrichales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_190003_2 765912.Thimo_2852 2.23e-23 90.5 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_41046_1 562970.Btus_0589 2.61e-27 109.0 COG0387@1|root,COG0387@2|Bacteria,1TQN2@1239|Firmicutes,4HB3X@91061|Bacilli,277X8@186823|Alicyclobacillaceae 91061|Bacilli P Sodium/calcium exchanger protein cax GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015085,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015368,GO:0015369,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051139,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - ko:K07300 - - - - ko00000,ko02000 2.A.19 - - Na_Ca_ex k59_41046_2 880072.Desac_0182 0.000395 43.5 COG0351@1|root,COG1992@1|root,COG0351@2|Bacteria,COG1992@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2WK2V@28221|Deltaproteobacteria,2MRF4@213462|Syntrophobacterales 28221|Deltaproteobacteria H Thiamine-phosphate synthase thiD - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00941,ko:K14153,ko:K21219 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2909 Phos_pyr_kin,TMP-TENI,ThiP_synth k59_66601_1 1049564.TevJSym_ad00860 1.86e-121 352.0 COG1432@1|root,COG1432@2|Bacteria 2|Bacteria S NYN domain - - - - - - - - - - - - CSD,NYN k59_112168_1 1318628.MARLIPOL_12709 3.56e-182 519.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,4644B@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG4962 Flp pilus assembly protein, ATPase CpaF tadA - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_112168_2 1318628.MARLIPOL_12704 1.09e-77 247.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,1S1QN@1236|Gammaproteobacteria,469CH@72275|Alteromonadaceae 1236|Gammaproteobacteria U Type II secretion system (T2SS), protein F tadB - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_73057_2 1049564.TevJSym_be00380 1.27e-29 108.0 COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SF76@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_73057_3 765913.ThidrDRAFT_1859 1.92e-131 385.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1WW4C@135613|Chromatiales 135613|Chromatiales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_73057_4 1283300.ATXB01000002_gene2567 2.65e-47 158.0 COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria,1XFJZ@135618|Methylococcales 135618|Methylococcales I COG0575 CDP-diglyceride synthetase - - - - - - - - - - - - CarS-like k59_27883_1 690850.Desaf_2080 1.7e-85 271.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2M845@213115|Desulfovibrionales 28221|Deltaproteobacteria BQ PFAM Histone deacetylase - - - - - - - - - - - - Acetyltransf_1,Hist_deacetyl k59_131831_1 484770.UFO1_1290 8.28e-90 281.0 COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,4H243@909932|Negativicutes 909932|Negativicutes F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,ThiI,tRNA_Me_trans k59_144764_1 1123393.KB891316_gene2094 1.15e-17 82.8 COG5581@1|root,COG5581@2|Bacteria,1N1D2@1224|Proteobacteria,2WBGA@28216|Betaproteobacteria,1KRV5@119069|Hydrogenophilales 119069|Hydrogenophilales M Flagellar protein YcgR - - - - - - - - - - - - PilZ,YcgR_2 k59_163958_2 1109445.AGSX01000039_gene204 3.45e-08 62.0 COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,1T1XV@1236|Gammaproteobacteria,1Z2BR@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T Cache 3/Cache 2 fusion domain - - 2.7.13.3 ko:K02480 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3,sCache_2 k59_163958_5 1353531.AZNX01000005_gene3327 5.43e-97 311.0 COG4287@1|root,COG4287@2|Bacteria,1NP5V@1224|Proteobacteria 1224|Proteobacteria O PhoPQ-activated pathogenicity-related protein pqaA - - - - - - - - - - - PhoPQ_related k59_163958_6 523791.Kkor_1525 2.56e-22 102.0 COG2984@1|root,COG2984@2|Bacteria,1NACH@1224|Proteobacteria,1SEI1@1236|Gammaproteobacteria,1XKXH@135619|Oceanospirillales 135619|Oceanospirillales S ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind k59_8442_1 765910.MARPU_06335 8.37e-100 303.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWTP@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K10126,ko:K10943 ko02020,ko05111,map02020,map05111 M00504,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_14544_6 306281.AJLK01000020_gene2978 1.21e-05 53.5 COG3409@1|root,COG3409@2|Bacteria,1GESW@1117|Cyanobacteria,1JIWW@1189|Stigonemataceae 1117|Cyanobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_41068_1 1190603.AJYD01000037_gene1242 0.000181 49.3 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1XTUZ@135623|Vibrionales 135623|Vibrionales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_131839_1 572546.Arcpr_0878 3.51e-21 89.0 COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,246AV@183980|Archaeoglobi 183980|Archaeoglobi K Transcriptional regulator, TrmB - - - - - - - - - - - - - k59_53666_1 1255043.TVNIR_3223 9.67e-140 403.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_125355_1 1439940.BAY1663_01811 2.13e-71 243.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_105540_1 349521.HCH_07064 4.78e-24 101.0 COG3677@1|root,COG3677@2|Bacteria,1N87H@1224|Proteobacteria,1T18J@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Tn7-like transposition protein D - - - - - - - - - - - - TniQ,TnsD k59_105540_2 1219072.VHA01S_031_00240 1.02e-89 284.0 COG2842@1|root,COG2842@2|Bacteria,1MV76@1224|Proteobacteria,1RPTQ@1236|Gammaproteobacteria,1XTBE@135623|Vibrionales 135623|Vibrionales S Bacterial TniB protein - - - - - - - - - - - - AAA_22 k59_79962_1 909663.KI867150_gene2398 3.5e-137 399.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MQ79@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS-1 - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_66625_1 1297569.MESS2_750022 7.72e-23 95.1 COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2UBM9@28211|Alphaproteobacteria,43JSN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q protein possibly involved in aromatic compounds catabolism - - - - - - - - - - - - 4HBT k59_131842_1 690850.Desaf_1226 7.95e-54 175.0 COG2204@1|root,COG2204@2|Bacteria,1RCHU@1224|Proteobacteria,42QWT@68525|delta/epsilon subdivisions,2WN23@28221|Deltaproteobacteria,2MAFK@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg,STAS,STAS_2 k59_177069_1 195250.CM001776_gene949 3.14e-71 239.0 COG0358@1|root,COG0358@2|Bacteria 2|Bacteria L DNA primase activity - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_53667_1 237368.SCABRO_01860 2.81e-37 141.0 COG2905@1|root,COG3290@1|root,COG2905@2|Bacteria,COG3290@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,HATPase_c_5,PAS,PAS_9,SpoIIE,cNMP_binding k59_41075_1 713586.KB900536_gene1962 5.88e-101 312.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase S15 cocE - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_47295_3 316273.XCV2181 8.48e-212 593.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,1RPW8@1236|Gammaproteobacteria,1X7F3@135614|Xanthomonadales 135614|Xanthomonadales Q Cytochrome P450 - - - - - - - - - - - - p450 k59_47295_4 316273.XCV2180 7.32e-43 142.0 COG0633@1|root,COG0633@2|Bacteria,1N1GV@1224|Proteobacteria,1SBNB@1236|Gammaproteobacteria,1X90P@135614|Xanthomonadales 135614|Xanthomonadales C 2Fe-2S iron-sulfur cluster binding domain - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_47295_5 1288494.EBAPG3_5740 9.39e-193 570.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,2VJDF@28216|Betaproteobacteria 28216|Betaproteobacteria M rhs element vgr protein - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD k59_139779_1 930166.CD58_11795 9.49e-182 531.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria 1224|Proteobacteria T Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_69080_1 1304275.C41B8_18316 2.04e-18 83.2 2DBKX@1|root,2Z9W9@2|Bacteria,1MX78@1224|Proteobacteria,1S1M6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3577) - - - - - - - - - - - - DUF3577 k59_16460_1 1167006.UWK_03157 4.21e-29 117.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Pyridine nucleotide-disulphide oxidoreductase bamE - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2 k59_204826_1 1121448.DGI_2643 5.22e-86 269.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_146645_1 335543.Sfum_3207 3.07e-59 194.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42PRS@68525|delta/epsilon subdivisions,2WK0H@28221|Deltaproteobacteria 28221|Deltaproteobacteria EH PFAM aminotransferase, class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_100839_1 754476.Q7A_1127 1.12e-117 342.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,45ZPM@72273|Thiotrichales 72273|Thiotrichales E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_95599_1 570952.ATVH01000014_gene2255 1.4e-73 246.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2JPTT@204441|Rhodospirillales 204441|Rhodospirillales C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_146651_1 1034769.KB910518_gene3243 1.25e-39 147.0 COG1903@1|root,COG1903@2|Bacteria,1TQ3M@1239|Firmicutes,4HBDG@91061|Bacilli,26R5X@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_69088_1 439235.Dalk_3789 3.68e-99 306.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,42P5R@68525|delta/epsilon subdivisions,2WJDU@28221|Deltaproteobacteria,2MI4P@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_186014_3 1121373.KB903664_gene2551 2.15e-42 150.0 COG0644@1|root,COG0644@2|Bacteria,4NEI6@976|Bacteroidetes,47MPG@768503|Cytophagia 976|Bacteroidetes C Tryptophan halogenase fixC - - - - - - - - - - - Trp_halogenase k59_152995_1 1232410.KI421421_gene3701 3.56e-23 93.2 COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,42U9S@68525|delta/epsilon subdivisions,2WQ1X@28221|Deltaproteobacteria,43SN2@69541|Desulfuromonadales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF882) ycbK - - - - - - - - - - - Peptidase_M15_2 k59_23649_1 880526.KE386488_gene168 4.26e-07 56.2 COG0582@1|root,COG0582@2|Bacteria,4NDZJ@976|Bacteroidetes,2FM4Q@200643|Bacteroidia,22UR0@171550|Rikenellaceae 976|Bacteroidetes L Arm DNA-binding domain - - - - - - - - - - - - Arm-DNA-bind_5,Phage_int_SAM_5,Phage_integrase k59_165837_1 1415780.JPOG01000001_gene1425 6.71e-113 337.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RNDN@1236|Gammaproteobacteria,1X5P2@135614|Xanthomonadales 135614|Xanthomonadales E Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs avtA - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_100847_1 323848.Nmul_A1150 7.68e-11 65.9 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales 28216|Betaproteobacteria CEH PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_62690_2 395494.Galf_1907 6.83e-112 335.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,44VRA@713636|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase,HTH_6,SIS k59_62690_3 987059.RBXJA2T_02000 2.67e-179 506.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,1KMH8@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Di-haem cytochrome c peroxidase ccp - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_133862_1 1346330.M472_10805 1.6e-48 177.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG4251@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,4NFBM@976|Bacteroidetes,1INN9@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,NIT,Response_reg k59_146660_1 1168065.DOK_02321 3.17e-117 347.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1J7R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_10685_1 765914.ThisiDRAFT_0962 1.67e-98 317.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_121340_1 1232410.KI421421_gene3768 4.94e-272 782.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,43S1Y@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_63012_3 765911.Thivi_0796 2.81e-229 684.0 COG4262@1|root,COG4262@2|Bacteria,1RFZS@1224|Proteobacteria,1S1NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_63012_4 1167006.UWK_02651 7.62e-22 104.0 COG1196@1|root,COG2885@1|root,COG1196@2|Bacteria,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WN8R@28221|Deltaproteobacteria,2MPGW@213118|Desulfobacterales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA,TSP_3 k59_63012_7 999541.bgla_2g00490 4.34e-10 58.9 COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,2VWGX@28216|Betaproteobacteria,1K8N0@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_63012_8 1117319.PSPO_06283 5.74e-107 319.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,1RZD9@1236|Gammaproteobacteria,2Q3ZC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NU Type II secretion system (T2SS), protein F tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_63012_9 1117319.PSPO_06278 1.17e-92 282.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,1S1QN@1236|Gammaproteobacteria,2Q4EG@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U Type II secretion system (T2SS), protein F tadB - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_63012_10 1177179.A11A3_11678 1.05e-234 666.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1XN1M@135619|Oceanospirillales 135619|Oceanospirillales U COG4962 Flp pilus assembly protein, ATPase CpaF - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_63012_11 568706.BN118_1005 1.04e-39 156.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VJZG@28216|Betaproteobacteria,3T2GP@506|Alcaligenaceae 28216|Betaproteobacteria U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_63012_12 392500.Swoo_0750 6.13e-26 112.0 COG3745@1|root,COG3745@2|Bacteria,1RDTQ@1224|Proteobacteria,1SD8S@1236|Gammaproteobacteria,2QEG9@267890|Shewanellaceae 1236|Gammaproteobacteria U Flp pilus assembly protein RcpC/CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_63012_16 1209072.ALBT01000009_gene3091 9.05e-76 247.0 COG4961@1|root,COG4961@2|Bacteria,1QVT9@1224|Proteobacteria,1T4AS@1236|Gammaproteobacteria 1236|Gammaproteobacteria U PFAM TadE family protein - - - - - - - - - - - - Tad k59_63012_17 1191460.F959_01150 5.38e-20 83.6 2E7CE@1|root,331VM@2|Bacteria,1N6U9@1224|Proteobacteria,1SDQ6@1236|Gammaproteobacteria,3NQ0M@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_205122_1 768671.ThimaDRAFT_1033 5.75e-99 302.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1WWSU@135613|Chromatiales 135613|Chromatiales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_69518_1 563040.Saut_1467 7.62e-08 54.7 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2YPDX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GatB Yqey family protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_95976_1 1286106.MPL1_00702 1.16e-42 141.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,460Q2@72273|Thiotrichales 72273|Thiotrichales K nitrogen regulatory protein P-II - - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_95976_2 765912.Thimo_0097 4.24e-219 615.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_95976_4 903503.MEPCIT_361 7.08e-16 74.7 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system tusE GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_95976_5 1049564.TevJSym_at00700 4.21e-78 255.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1J4YE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_82293_1 335543.Sfum_3055 8.92e-179 517.0 COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MR6M@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the ClpX chaperone family - - - - - - - - - - - - AAA_2,ClpB_D2-small k59_101145_1 879212.DespoDRAFT_01781 2.51e-11 69.7 COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria,2MHV1@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 k59_101145_2 987059.RBXJA2T_15658 1.25e-27 107.0 COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,2VKE3@28216|Betaproteobacteria,1KJ4I@119065|unclassified Burkholderiales 28216|Betaproteobacteria K regulatory - - - - - - - - - - - - TetR_N k59_186398_1 99598.Cal7507_5689 2.54e-22 96.7 COG0616@1|root,COG0616@2|Bacteria,1G1QV@1117|Cyanobacteria,1HIK1@1161|Nostocales 1117|Cyanobacteria OU TIGRFAM signal peptide peptidase SppA, 36K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_16792_1 335543.Sfum_0314 1.03e-61 202.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MRX0@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_192263_1 555778.Hneap_0157 6e-10 67.8 COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,1RJQP@1224|Proteobacteria,1SCDJ@1236|Gammaproteobacteria,1X11X@135613|Chromatiales 135613|Chromatiales S Lysin motif - - - - - - - - - - - - LysM,TPR_2,TPR_8 k59_192263_3 765913.ThidrDRAFT_2268 8.97e-73 230.0 COG3913@1|root,COG3913@2|Bacteria,1N01G@1224|Proteobacteria,1S6EQ@1236|Gammaproteobacteria,1WYTI@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2094) - - - ko:K11890 ko02025,map02025 - - - ko00000,ko00001,ko02044 - - - DUF2094 k59_114462_1 631362.Thi970DRAFT_04233 1.91e-153 448.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1X04D@135613|Chromatiales 135613|Chromatiales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_55723_1 335543.Sfum_2759 2.42e-96 293.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MQ82@213462|Syntrophobacterales 28221|Deltaproteobacteria F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - AIRC,GARS_A,GARS_C,GARS_N k59_186407_1 706587.Desti_3008 1.43e-53 190.0 COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1NU8B@1224|Proteobacteria,43D9U@68525|delta/epsilon subdivisions,2WIJG@28221|Deltaproteobacteria 2|Bacteria KT PFAM Bacterial regulatory protein, Fis family - - - ko:K17763 - - - - ko00000,ko03021 - - - GAF,GAF_2,HTH_8,PAS,PAS_3,PAS_4,PAS_9,STAS,Sigma54_activat,SpoIIE k59_121793_1 639282.DEFDS_1851 1.5e-32 126.0 COG0439@1|root,COG0439@2|Bacteria 2|Bacteria I biotin carboxylase activity - - - - - - - - - - - - ATP-grasp_3 k59_192267_1 1125863.JAFN01000001_gene469 2.43e-06 51.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria 1224|Proteobacteria T Bacterial regulatory protein, Fis family actB - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_140206_3 243233.MCA0072 1.7e-101 302.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales 135618|Methylococcales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_69543_1 439235.Dalk_0092 1.24e-47 175.0 COG1413@1|root,COG2199@1|root,COG3899@1|root,COG1413@2|Bacteria,COG2199@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain cpeY - 2.7.11.1,2.7.7.65 ko:K05385,ko:K12132,ko:K13590 ko00196,ko01100,ko04112,map00196,map01100,map04112 - - - ko00000,ko00001,ko00194,ko01000,ko01001 - - - AAA_16,EAL,GGDEF,Trans_reg_C k59_147033_1 439235.Dalk_3416 6.93e-60 199.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,42ZAR@68525|delta/epsilon subdivisions,2WU8I@28221|Deltaproteobacteria,2MN1D@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_179568_1 335543.Sfum_3479 7.02e-113 357.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MQ8P@213462|Syntrophobacterales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_108212_2 1198232.CYCME_0537 1.11e-46 160.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,45ZN5@72273|Thiotrichales 72273|Thiotrichales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_198334_1 933262.AXAM01000106_gene2631 1.28e-41 148.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales 28221|Deltaproteobacteria S Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_198334_2 933262.AXAM01000106_gene2631 2.26e-26 107.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales 28221|Deltaproteobacteria S Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_95990_3 713587.THITH_02840 4.33e-87 269.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales 135613|Chromatiales S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_186416_1 1163730.FFONT_1152 1.98e-21 91.7 arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota 28889|Crenarchaeota M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Rubrerythrin k59_37097_2 693661.Arcve_1735 2.58e-05 44.3 COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota,247FC@183980|Archaeoglobi 183980|Archaeoglobi S TRAM domain - - - - - - - - - - - - TRAM k59_195076_4 665952.HMPREF1015_01838 2.24e-31 129.0 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4HA0W@91061|Bacilli,1ZC8V@1386|Bacillus 91061|Bacilli L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_195076_5 477228.YO5_14850 9.08e-129 380.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1Z1QF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_195076_6 1049564.TevJSym_aq00270 2.04e-230 644.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1J5A3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_72039_1 477974.Daud_1944 3.02e-42 143.0 COG0778@1|root,COG0778@2|Bacteria,1V4ZI@1239|Firmicutes,24BD0@186801|Clostridia,261YM@186807|Peptococcaceae 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_72039_2 903814.ELI_4317 8.07e-48 164.0 COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,25WNA@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF554) - - - ko:K07150 - - - - ko00000 - - - DUF554 k59_65534_1 1049564.TevJSym_ac01650 1.22e-33 125.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1J4MD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component yadG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_65534_2 1049564.TevJSym_ac01640 8.97e-128 369.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1J4RI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0842 ABC-type multidrug transport system, permease component yadH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_65534_3 1049564.TevJSym_ab00900 1.56e-65 201.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_13616_1 99598.Cal7507_3916 9.54e-109 336.0 COG0318@1|root,COG0318@2|Bacteria,1G4CE@1117|Cyanobacteria,1HJ2S@1161|Nostocales 1117|Cyanobacteria IQ AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding k59_13616_2 194439.CT0309 2.32e-10 61.6 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1FEDY@1090|Chlorobi 1090|Chlorobi M Cupin 2, conserved barrel domain protein - - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_13616_3 754476.Q7A_1096 3.6e-242 676.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,46050@72273|Thiotrichales 72273|Thiotrichales G Phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_13616_4 264730.PSPPH_0954 6.43e-116 340.0 COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,1S0H9@1236|Gammaproteobacteria,1Z8RA@136849|Pseudomonas syringae group 1236|Gammaproteobacteria V ABC-2 type transporter wzm - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_13616_5 1179778.PMM47T1_16163 1.17e-135 395.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,1RN2T@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM ABC-type polysaccharide polyol phosphate transport system ATPase component wzt - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_39546_1 215803.DB30_0359 1.09e-05 53.5 COG3712@1|root,COG3712@2|Bacteria,1PBZ9@1224|Proteobacteria,433U5@68525|delta/epsilon subdivisions,2X3GP@28221|Deltaproteobacteria,2YW0J@29|Myxococcales 28221|Deltaproteobacteria PT FecR protein - - - - - - - - - - - - FecR,zf-HC2 k59_143289_1 388739.RSK20926_01837 5.07e-90 275.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2P4KV@2433|Roseobacter 28211|Alphaproteobacteria C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_46056_1 195253.Syn6312_1172 3.23e-10 60.1 28H88@1|root,2Z7K7@2|Bacteria,1GC0T@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_46056_3 1217658.F987_02146 1.34e-05 49.7 COG4387@1|root,COG4387@2|Bacteria,1N1K0@1224|Proteobacteria,1SFEH@1236|Gammaproteobacteria,3NP8E@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1320) - - - - - - - - - - - - DUF1320 k59_46056_4 740709.A10D4_12699 2.41e-08 55.8 COG5005@1|root,COG5005@2|Bacteria,1RCHJ@1224|Proteobacteria,1S31U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage virion morphogenesis - - - - - - - - - - - - Phage_tail_S k59_195077_1 1049564.TevJSym_ac01690 9.27e-59 187.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1JA86@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 k59_195077_2 1049564.TevJSym_ac01700 1.43e-178 519.0 COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T pfam chad - - - - - - - - - - - - CHAD,His_Phos_1 k59_620_1 1049564.TevJSym_ak00050 9.95e-99 294.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1J4EA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849 Porphobil_deam,Porphobil_deamC k59_620_2 768671.ThimaDRAFT_2332 1.6e-73 231.0 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_620_3 1049564.TevJSym_ak00070 3.13e-70 233.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1J63W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317 HemX k59_620_4 1049564.TevJSym_ak00080 1.57e-140 415.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1J5RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_620_5 335543.Sfum_2171 9.35e-103 325.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MR6I@213462|Syntrophobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_620_6 111781.Lepto7376_3661 4.36e-42 155.0 28JNF@1|root,2Z9ER@2|Bacteria,1G4IA@1117|Cyanobacteria,1HESS@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_620_8 443144.GM21_0559 9.69e-07 50.1 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - - - - - - - - - - PP-binding k59_620_9 1123321.KB905821_gene4318 7.63e-155 457.0 COG1020@1|root,COG1020@2|Bacteria,2GP0R@201174|Actinobacteria 201174|Actinobacteria Q Belongs to the ATP-dependent AMP-binding enzyme family - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_620_10 1449048.JQKU01000006_gene5160 1.36e-42 160.0 COG1960@1|root,COG1960@2|Bacteria,2I5JQ@201174|Actinobacteria,237K9@1762|Mycobacteriaceae 201174|Actinobacteria I PFAM Acyl-CoA oxidase dehydrogenase, type 1 - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_620_11 1463854.JOHT01000002_gene2314 1.38e-45 160.0 COG3208@1|root,COG3208@2|Bacteria,2GMY8@201174|Actinobacteria 201174|Actinobacteria Q Thioesterase - - - - - - - - - - - - Thioesterase k59_620_12 489825.LYNGBM3L_11280 7.6e-166 569.0 COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1H927@1150|Oscillatoriales 1117|Cyanobacteria Q Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - - - - - - - - - - ADH_N,ADH_zinc_N_2,AMP-binding,Abhydrolase_1,Acyl_transf_1,Hydrolase_4,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Sulfotransfer_3,ketoacyl-synt k59_620_13 426117.M446_0172 0.0 1451.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria,1JS6P@119045|Methylobacteriaceae 28211|Alphaproteobacteria CQ PFAM short-chain dehydrogenase reductase SDR - - - ko:K12436 - - - - ko00000,ko01004 - - - ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_620_14 91464.S7335_3862 0.0 1142.0 COG0318@1|root,COG0604@1|root,COG3321@1|root,COG0318@2|Bacteria,COG0604@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1H02I@1129|Synechococcus 1117|Cyanobacteria Q Q COG3321 Polyketide synthase modules and related proteins mcyG - - ko:K16127 ko01054,map01054 - - - ko00000,ko00001,ko01008 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_620_15 251229.Chro_3658 1.12e-300 879.0 COG1020@1|root,COG1020@2|Bacteria,1GBN8@1117|Cyanobacteria,3VKWD@52604|Pleurocapsales 1117|Cyanobacteria Q Condensation domain - - - ko:K12240 ko01053,map01053 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding k59_620_16 1463856.JOHY01000049_gene4888 4e-93 329.0 COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_72047_1 96561.Dole_1446 2.67e-81 266.0 COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MIQ1@213118|Desulfobacterales 28221|Deltaproteobacteria F ATP-grasp domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0661 CPSase_L_D2,CPSase_L_D3,MGS k59_123904_1 933262.AXAM01000016_gene182 9.01e-54 183.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_26699_1 156889.Mmc1_2506 5e-12 65.9 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C small subunit - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_130413_1 589865.DaAHT2_0484 1.05e-48 172.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_91405_1 1049564.TevJSym_ac00940 2.47e-95 301.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1J4SW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_91405_2 1049564.TevJSym_ab02100 1.37e-300 827.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_91405_3 1049564.TevJSym_ab02090 1.36e-185 522.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1J4SG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_143293_1 1499967.BAYZ01000018_gene6343 7.07e-84 261.0 COG0415@1|root,COG0415@2|Bacteria,2NQCC@2323|unclassified Bacteria 2|Bacteria L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_33109_2 322710.Avin_48710 2.13e-36 127.0 2BWYB@1|root,32W1H@2|Bacteria,1N1MW@1224|Proteobacteria,1SEGG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_33109_3 377629.TERTU_1548 1.82e-71 223.0 COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,1S0SJ@1236|Gammaproteobacteria,2PQ1V@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Glutathione S-transferase, N-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_2,GST_N_3 k59_33109_5 1056820.KB900674_gene2581 1.62e-21 87.0 2EKWN@1|root,33EK5@2|Bacteria,1NNJ5@1224|Proteobacteria,1SI4S@1236|Gammaproteobacteria,2PQHK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_33110_2 439235.Dalk_0645 2.98e-18 80.1 COG1516@1|root,COG1516@2|Bacteria,1PSYY@1224|Proteobacteria,42V8K@68525|delta/epsilon subdivisions,2WRH1@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_20091_3 1555208.A0A097EW18_9CAUD 2.22e-41 160.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_20091_8 1484479.DI14_04805 2.8e-123 370.0 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,4HCUQ@91061|Bacilli,3WF0I@539002|Bacillales incertae sedis 91061|Bacilli S Terminase RNAseH like domain - - - - - - - - - - - - Terminase_3,Terminase_3C k59_20091_9 97138.C820_00238 2.37e-33 139.0 2CEGT@1|root,2Z7ZB@2|Bacteria,1TP3Y@1239|Firmicutes,24CBJ@186801|Clostridia,36HMF@31979|Clostridiaceae 186801|Clostridia S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_20091_13 398512.JQKC01000052_gene2672 8.76e-61 203.0 2C8MZ@1|root,2ZA7T@2|Bacteria,1UFFD@1239|Firmicutes,24F4E@186801|Clostridia,3WN3M@541000|Ruminococcaceae 186801|Clostridia S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_39560_1 1049564.TevJSym_ao00380 2.74e-233 667.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1J9K4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_201758_3 1122915.AUGY01000047_gene1433 1.22e-06 56.2 COG1132@1|root,COG1132@2|Bacteria,1TQAN@1239|Firmicutes,4HBES@91061|Bacilli,26QHI@186822|Paenibacillaceae 91061|Bacilli V ABC-type multidrug transport system, ATPase and permease hetA - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_7257_1 998674.ATTE01000001_gene3341 1.77e-20 83.6 2AMWN@1|root,31CTF@2|Bacteria,1NEAZ@1224|Proteobacteria,1SHED@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_7257_2 1117318.PRUB_04511 1.2e-66 227.0 COG1413@1|root,COG1413@2|Bacteria,1MYD9@1224|Proteobacteria,1S622@1236|Gammaproteobacteria 1236|Gammaproteobacteria C lyase activity - - - - - - - - - - - - - k59_104385_1 1049564.TevJSym_an00390 1.93e-224 625.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1J4P4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_156567_2 690850.Desaf_3188 3.68e-28 118.0 COG5002@1|root,COG5002@2|Bacteria,1R6WE@1224|Proteobacteria,42P99@68525|delta/epsilon subdivisions,2WK5E@28221|Deltaproteobacteria,2M9XP@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11383 ko02020,map02020 M00505 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8 k59_117755_1 1121405.dsmv_1721 1.37e-73 235.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_7540_1 1049564.TevJSym_ab01210 7.56e-47 167.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_7540_2 1049564.TevJSym_ab01040 7.85e-23 96.3 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_202060_1 335543.Sfum_0588 1.38e-82 258.0 COG2704@1|root,COG2704@2|Bacteria,1MVHH@1224|Proteobacteria,42MDH@68525|delta/epsilon subdivisions,2WU9Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane - - - ko:K07791 - - - - ko00000,ko02000 2.A.13.1 - - DcuA_DcuB k59_873_2 1116472.MGMO_11c00730 8.39e-49 161.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria,1XF7D@135618|Methylococcales 135618|Methylococcales C Thioredoxin-like [2Fe-2S] ferredoxin - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - 2Fe-2S_thioredx k59_873_3 1158292.JPOE01000005_gene1259 1.38e-57 191.0 COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2VMWX@28216|Betaproteobacteria,1KJR6@119065|unclassified Burkholderiales 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_59384_1 335543.Sfum_0929 8.98e-96 310.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_111249_1 313606.M23134_07499 3.04e-50 171.0 COG0501@1|root,COG0501@2|Bacteria,4PA0G@976|Bacteroidetes,47SGP@768503|Cytophagia 976|Bacteroidetes O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_39886_1 1265505.ATUG01000001_gene3010 1.65e-61 206.0 COG3156@1|root,COG3156@2|Bacteria,1PZ6I@1224|Proteobacteria,42Q46@68525|delta/epsilon subdivisions,2WM8B@28221|Deltaproteobacteria,2MI8C@213118|Desulfobacterales 28221|Deltaproteobacteria U General secretion pathway protein K - - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_20391_1 1382306.JNIM01000001_gene1046 1.45e-20 93.2 COG4585@1|root,COG4585@2|Bacteria,2G6F0@200795|Chloroflexi 200795|Chloroflexi T histidine kinase, dimerisation and phosphoacceptor region - - - - - - - - - - - - HAMP,HATPase_c,HisKA_3,sCache_3_2 k59_20391_2 984262.SGRA_0603 4.1e-16 77.4 COG2197@1|root,COG2197@2|Bacteria,4NQNY@976|Bacteroidetes,1ISXA@117747|Sphingobacteriia 976|Bacteroidetes K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_27007_1 665571.STHERM_c03350 1.38e-50 171.0 COG2078@1|root,COG2078@2|Bacteria,2J7B9@203691|Spirochaetes 203691|Spirochaetes S AMMECR1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_130757_1 765913.ThidrDRAFT_1672 3.46e-117 341.0 COG1028@1|root,COG1028@2|Bacteria,1MW4W@1224|Proteobacteria,1RRSA@1236|Gammaproteobacteria,1WXS6@135613|Chromatiales 135613|Chromatiales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_130757_2 362663.ECP_1851 3.38e-19 86.3 COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,1RRDM@1236|Gammaproteobacteria,3XMQH@561|Escherichia 1236|Gammaproteobacteria S Belongs to the UPF0149 family yecA - - ko:K07039 - - - - ko00000 - - - SEC-C,UPF0149 k59_39890_1 177437.HRM2_30650 5.77e-63 205.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2MIPC@213118|Desulfobacterales 28221|Deltaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_42827_1 439235.Dalk_2732 3.94e-33 123.0 COG1321@1|root,COG1321@2|Bacteria,1RH2Z@1224|Proteobacteria,42U02@68525|delta/epsilon subdivisions,2X6HI@28221|Deltaproteobacteria,2MQ1G@213118|Desulfobacterales 28221|Deltaproteobacteria K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress k59_165210_1 335543.Sfum_3869 1.28e-130 382.0 COG1801@1|root,COG1801@2|Bacteria,1MXIQ@1224|Proteobacteria,42XHB@68525|delta/epsilon subdivisions,2WSKY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_133205_1 933262.AXAM01000010_gene1402 7.95e-91 274.0 COG0484@1|root,COG0705@1|root,COG0484@2|Bacteria,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MI6P@213118|Desulfobacterales 28221|Deltaproteobacteria O Rhomboid family - - - ko:K07059 - - - - ko00000 - - - DnaJ_C,Rhomboid k59_133205_2 335543.Sfum_3216 9.51e-34 124.0 COG1413@1|root,COG1413@2|Bacteria,1R6G4@1224|Proteobacteria,42T2X@68525|delta/epsilon subdivisions,2WPNC@28221|Deltaproteobacteria,2MRRI@213462|Syntrophobacterales 28221|Deltaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2,HEAT_EZ k59_15728_2 768671.ThimaDRAFT_3101 3.59e-148 431.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1WXRI@135613|Chromatiales 135613|Chromatiales E Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_54865_1 1279017.AQYJ01000029_gene3786 1.23e-11 63.9 COG4508@1|root,COG4508@2|Bacteria,1RAX1@1224|Proteobacteria,1RYFG@1236|Gammaproteobacteria,465HS@72275|Alteromonadaceae 1236|Gammaproteobacteria S dUTPase dut - - - - - - - - - - - dUTPase_2 k59_158913_1 398767.Glov_2700 2.61e-34 127.0 COG2199@1|root,COG3706@2|Bacteria,1RAKG@1224|Proteobacteria,42QYD@68525|delta/epsilon subdivisions,2WN6A@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_9 k59_94729_1 1111069.TCCBUS3UF1_3770 1.35e-54 175.0 COG1764@1|root,COG1764@2|Bacteria,1WJVD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O redox protein regulator of disulfide bond formation osmC - - ko:K04063 - - - - ko00000 - - - OsmC k59_171955_1 748658.KB907312_gene1608 1.34e-36 132.0 COG0705@1|root,COG0705@2|Bacteria,1RJYI@1224|Proteobacteria,1S0FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid k59_74202_1 439235.Dalk_0522 2.57e-110 332.0 COG1304@1|root,COG1304@2|Bacteria,1P72V@1224|Proteobacteria,42NSD@68525|delta/epsilon subdivisions,2WJRW@28221|Deltaproteobacteria,2MHNN@213118|Desulfobacterales 28221|Deltaproteobacteria C Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_42833_1 335543.Sfum_4070 8.24e-82 253.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_42833_2 941449.dsx2_2930 1.44e-05 47.0 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor livK-1 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iAF987.Gmet_1823 Peripla_BP_6 k59_94730_1 717774.Marme_2330 1.6e-06 56.6 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1XR5H@135619|Oceanospirillales 135619|Oceanospirillales KLT COG0515 Serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_113594_2 1121403.AUCV01000056_gene3012 4.62e-64 210.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_68485_1 335543.Sfum_1549 6.7e-158 484.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_15905_1 1179773.BN6_58700 2.22e-07 57.8 COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4E3GG@85010|Pseudonocardiales 201174|Actinobacteria Q Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_87725_1 439235.Dalk_5221 8.49e-67 228.0 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MI4C@213118|Desulfobacterales 28221|Deltaproteobacteria J CBS domain ccaA - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_185399_1 1121440.AUMA01000011_gene2420 9.25e-18 79.3 2B047@1|root,31SEM@2|Bacteria,1RHZY@1224|Proteobacteria,42V93@68525|delta/epsilon subdivisions,2WVVI@28221|Deltaproteobacteria,2MCS3@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_185399_2 1238182.C882_4460 4.44e-44 149.0 2ATAH@1|root,31ITJ@2|Bacteria,1RIQF@1224|Proteobacteria,2UD6U@28211|Alphaproteobacteria,2JTD0@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_178719_1 670307.HYPDE_28363 5.34e-147 429.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N7QG@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria T Sigma-54 interaction domain hoxA - - ko:K19641 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_74376_3 102129.Lepto7375DRAFT_2519 5.49e-26 117.0 COG3409@1|root,COG3409@2|Bacteria,1GQNA@1117|Cyanobacteria 1117|Cyanobacteria M Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_139321_1 1121405.dsmv_3269 6.92e-62 210.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MJ96@213118|Desulfobacterales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_15907_1 1121405.dsmv_1048 9.82e-67 213.0 COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,42N8A@68525|delta/epsilon subdivisions,2WKHD@28221|Deltaproteobacteria,2MIHV@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_15907_2 96561.Dole_2107 1.94e-16 74.3 28NQ4@1|root,2ZBPU@2|Bacteria,1RCN1@1224|Proteobacteria,42QPC@68525|delta/epsilon subdivisions,2WMVS@28221|Deltaproteobacteria,2MJR9@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_152485_1 1249627.D779_1200 5.31e-241 684.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_36120_2 1249480.B649_03920 8.42e-47 159.0 COG0656@1|root,COG0656@2|Bacteria,1PGB3@1224|Proteobacteria,42PPT@68525|delta/epsilon subdivisions,2YN3U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_43146_1 1187848.AJYQ01000008_gene532 2.36e-106 319.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1XTGB@135623|Vibrionales 135623|Vibrionales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC2 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_165374_3 317025.Tcr_0436 4.93e-16 76.6 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,1S5NE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_100409_1 1348583.ATLH01000003_gene3904 3.32e-40 142.0 2ABTU@1|root,311AE@2|Bacteria,4PG2G@976|Bacteroidetes,1IMK9@117743|Flavobacteriia,1F9WS@104264|Cellulophaga 976|Bacteroidetes - - - - - - - - - - - - - - - k59_87729_1 933262.AXAM01000053_gene2705 2.93e-20 93.6 COG3233@1|root,COG3233@2|Bacteria,1RB7V@1224|Proteobacteria,42RBC@68525|delta/epsilon subdivisions,2WMQB@28221|Deltaproteobacteria,2MJK1@213118|Desulfobacterales 28221|Deltaproteobacteria S deacetylase - - - - - - - - - - - - - k59_107264_1 279238.Saro_2801 4.36e-147 433.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2K1ZD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_62082_1 926569.ANT_12300 4.45e-52 168.0 COG3293@1|root,COG3293@2|Bacteria,2G9EK@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_146240_1 1265313.HRUBRA_02565 3.29e-60 197.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_74380_1 1121403.AUCV01000010_gene1393 8.05e-41 135.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2MKMM@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_197535_2 1049564.TevJSym_br00030 4.18e-255 707.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,Fer4_8,RnfC_N,SLBB k59_197535_3 1049564.TevJSym_br00040 5.85e-11 62.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1J55P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfD2 - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_178722_1 768671.ThimaDRAFT_0944 1.26e-152 440.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_107266_1 335543.Sfum_2659 9.5e-77 242.0 COG3287@1|root,COG3287@2|Bacteria,1Q5S5@1224|Proteobacteria,431QC@68525|delta/epsilon subdivisions,2WWE6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_43154_1 748247.AZKH_p0398 1.08e-19 94.0 COG2199@1|root,COG3290@1|root,COG2199@2|Bacteria,COG3290@2|Bacteria,1RGCV@1224|Proteobacteria,2W303@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - CBS,CHASE,EAL,GGDEF,MASE1,PAS,PAS_4,PAS_9,dCache_1 k59_81506_1 1417296.U879_12725 7.53e-19 87.4 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_3022_2 509191.AEDB02000073_gene2010 3.51e-151 449.0 COG2942@1|root,COG2942@2|Bacteria 2|Bacteria G 2-epimerase VPA0780 - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim k59_3022_4 1001585.MDS_3001 1.06e-52 168.0 COG3324@1|root,COG3324@2|Bacteria,1N0AD@1224|Proteobacteria,1S8YM@1236|Gammaproteobacteria,1YJFM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase k59_10122_1 398512.JQKC01000052_gene2672 2.91e-22 94.4 2C8MZ@1|root,2ZA7T@2|Bacteria,1UFFD@1239|Firmicutes,24F4E@186801|Clostridia,3WN3M@541000|Ruminococcaceae 186801|Clostridia S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_120672_1 325777.GW15_0212610 2.34e-60 194.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1S179@1236|Gammaproteobacteria,1X3AJ@135614|Xanthomonadales 135614|Xanthomonadales T response regulator creB - - ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_68503_1 1174528.JH992893_gene5967 6.38e-129 387.0 COG1523@1|root,COG1523@2|Bacteria,1G0PW@1117|Cyanobacteria,1JKNR@1189|Stigonemataceae 1117|Cyanobacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_23085_1 1249627.D779_0258 2.94e-87 278.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales 135613|Chromatiales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_139327_1 1049564.TevJSym_ak00930 4.45e-125 359.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1J5G3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_139327_2 1049564.TevJSym_ak00940 2.6e-50 174.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1J4D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_36131_1 381666.H16_A0644 5.34e-18 77.4 2E4CR@1|root,32Z86@2|Bacteria,1N7UZ@1224|Proteobacteria,2VVR1@28216|Betaproteobacteria,1KA55@119060|Burkholderiaceae 28216|Betaproteobacteria S formate dehydrogenase fdsD - 1.17.1.9 ko:K00126 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - FdsD k59_36131_2 663610.JQKO01000001_gene797 2.54e-26 107.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2TUD2@28211|Alphaproteobacteria,3NAYS@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_204351_1 203122.Sde_0210 9.55e-157 462.0 290SY@1|root,2ZNF1@2|Bacteria,1P75Z@1224|Proteobacteria,1SV0A@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_29353_1 1049564.TevJSym_af00330 8.29e-109 330.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1J5X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DUF3394,DctM k59_48938_1 682795.AciX8_1941 5.51e-12 66.2 COG0639@1|root,COG0639@2|Bacteria,3Y3U2@57723|Acidobacteria,2JIPQ@204432|Acidobacteriia 204432|Acidobacteriia T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_120681_1 335543.Sfum_0988 1.73e-51 167.0 COG0454@1|root,COG0456@2|Bacteria,1RF31@1224|Proteobacteria,42RUB@68525|delta/epsilon subdivisions,2WN97@28221|Deltaproteobacteria,2MS1U@213462|Syntrophobacterales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_204358_1 933262.AXAM01000050_gene3484 2.75e-79 244.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2WJ8V@28221|Deltaproteobacteria,2MI49@213118|Desulfobacterales 28221|Deltaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,UbiA k59_133378_1 1122139.KB907862_gene796 4.49e-19 86.7 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1XHJ2@135619|Oceanospirillales 135619|Oceanospirillales C Domain of unknown function (DUF3483) - - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_133378_2 1535422.ND16A_3520 0.0 1050.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,2Q7HD@267889|Colwelliaceae 1236|Gammaproteobacteria C FAD dependent oxidoreductase dgcA - - ko:K21833 - - - - ko00000 - - - Oxidored_FMN,Pyr_redox_2 k59_133378_3 511062.GU3_07865 3.66e-82 247.0 COG1719@1|root,COG1719@2|Bacteria,1NP13@1224|Proteobacteria,1RQKJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrocarbon binding protein HA62_24390 - - - - - - - - - - - - k59_133378_4 1038860.AXAP01000002_gene4865 4.71e-189 530.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,3K3P8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_133378_5 247634.GPB2148_3632 2.21e-282 782.0 COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,1S1SA@1236|Gammaproteobacteria,1J8ND@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Trimethylamine methyltransferase (MTTB) - - - - - - - - - - - - MTTB k59_133378_6 1469245.JFBG01000006_gene1584 1.56e-123 367.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP3X@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - ko:K21826 - - - - ko00000,ko03000 - - - DJ-1_PfpI,HTH_18 k59_133378_7 1089551.KE386572_gene3992 1.7e-74 244.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,4BPT2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Domain of unknown function (DUF4445) nqrF - - - - - - - - - - - DUF4445,Fer2 k59_120685_1 933262.AXAM01000001_gene326 3.5e-131 399.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_43173_1 1211112.ALJC01000025_gene3657 6.59e-51 179.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria 1224|Proteobacteria T Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_43173_2 1232683.ADIMK_0774 1.66e-32 127.0 COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,1SZVU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR k59_139339_1 1049564.TevJSym_bf00110 5.61e-76 236.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter - - - - - - - - - - - - - k59_191577_2 56780.SYN_02957 8.18e-49 164.0 28PW7@1|root,32EDN@2|Bacteria,1N0AP@1224|Proteobacteria,42UF5@68525|delta/epsilon subdivisions,2WQ2P@28221|Deltaproteobacteria,2MR6Z@213462|Syntrophobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 k59_133380_1 261292.Nit79A3_2525 8.97e-31 120.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,2VKGR@28216|Betaproteobacteria,373JR@32003|Nitrosomonadales 28216|Betaproteobacteria L Transposase IS200 like - - - - - - - - - - - - HTH_28,Y1_Tnp k59_100438_1 317025.Tcr_0935 3.63e-54 180.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,460RS@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_62103_1 472759.Nhal_0103 2.51e-129 385.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales 135613|Chromatiales P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG k59_94988_5 177437.HRM2_48280 1.98e-82 249.0 COG4232@1|root,COG4232@2|Bacteria,1PK9S@1224|Proteobacteria,42PV0@68525|delta/epsilon subdivisions,2WJPK@28221|Deltaproteobacteria,2MIJ0@213118|Desulfobacterales 28221|Deltaproteobacteria CO PFAM Cytochrome C biogenesis protein transmembrane region dsbD - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_197552_1 378806.STAUR_6262 3.1e-29 117.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2YWEZ@29|Myxococcales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_23104_1 1122603.ATVI01000006_gene709 1.21e-64 209.0 COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,1RPST@1236|Gammaproteobacteria,1X7PR@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_10141_1 1168289.AJKI01000022_gene1913 1.85e-26 108.0 COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia,3XKII@558415|Marinilabiliaceae 976|Bacteroidetes EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_185659_1 639282.DEFDS_1851 3.11e-47 166.0 COG0439@1|root,COG0439@2|Bacteria 2|Bacteria I biotin carboxylase activity - - - - - - - - - - - - ATP-grasp_3 k59_135836_1 706587.Desti_2454 5.9e-87 268.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0036094,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0048037,GO:0050660,GO:0050662,GO:0051259,GO:0051262,GO:0052890,GO:0055114,GO:0065003,GO:0071840,GO:0097159,GO:1901265,GO:1901363 1.3.8.10,1.3.8.11 ko:K19066,ko:K19067 ko00362,ko01120,map00362,map01120 - R09252,R10601 RC00248,RC02035 ko00000,ko00001,ko01000 - - iAF987.Gmet_3306 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_199908_1 443152.MDG893_00712 9.59e-135 405.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,465FX@72275|Alteromonadaceae 1236|Gammaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_148633_1 682795.AciX8_4563 1.21e-05 55.8 COG2706@1|root,COG2706@2|Bacteria,3Y76Q@57723|Acidobacteria,2JMA2@204432|Acidobacteriia 204432|Acidobacteriia G Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase k59_38884_1 1121439.dsat_2305 3.89e-89 270.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_57099_1 1283300.ATXB01000001_gene856 1.06e-81 253.0 COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1S09S@1236|Gammaproteobacteria,1XG9D@135618|Methylococcales 135618|Methylococcales G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - - k59_64648_1 177437.HRM2_42210 3.44e-54 177.0 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,42Q7J@68525|delta/epsilon subdivisions,2WJCK@28221|Deltaproteobacteria,2MIR8@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD,Thioredoxin k59_31769_1 1282876.BAOK01000001_gene1464 2.23e-45 166.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BPAA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_161717_1 671143.DAMO_1319 2.24e-74 259.0 COG0457@1|root,COG3712@1|root,COG4773@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4773@2|Bacteria 2|Bacteria P Receptor - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - FecR,Plug,STN,TPR_16,TPR_8,TonB_dep_Rec k59_154888_1 70601.3257456 1.58e-56 189.0 COG2421@1|root,arCOG01004@2157|Archaea,2XTXT@28890|Euryarchaeota,243Z4@183968|Thermococci 183968|Thermococci C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA k59_199914_2 1408254.T458_11695 2.43e-18 83.6 COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,4HH8Z@91061|Bacilli,26VNV@186822|Paenibacillaceae 91061|Bacilli J Acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - Acetyltransf_3 k59_5262_2 439481.Aboo_0006 2.29e-16 84.0 COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F381@33867|unclassified Euryarchaeota 28890|Euryarchaeota N Type II/IV secretion system protein - - - ko:K07332 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_135852_1 158190.SpiGrapes_1752 1.62e-40 152.0 COG1509@1|root,COG1509@2|Bacteria 2|Bacteria E lysine 2,3-aminomutase activity eam - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Radical_SAM k59_173975_2 1049564.TevJSym_af00340 3.43e-128 375.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1J5X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DUF3394,DctM k59_154890_1 768671.ThimaDRAFT_2785 8.87e-117 353.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WWAZ@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_90208_1 338966.Ppro_1849 1.28e-11 67.0 COG1729@1|root,COG1729@2|Bacteria,1NE9U@1224|Proteobacteria,42W04@68525|delta/epsilon subdivisions,2WSHK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_161724_1 941449.dsx2_1935 3.88e-91 283.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBF@1224|Proteobacteria,42RAR@68525|delta/epsilon subdivisions,2WN52@28221|Deltaproteobacteria,2MAC7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - GAF,GAF_2,SpoIIE k59_116005_1 1430440.MGMSRv2_2134 6.3e-15 72.4 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,2JQJ3@204441|Rhodospirillales 204441|Rhodospirillales P COG1108 ABC-type Mn2 Zn2 transport systems, permease components znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_116005_2 1279017.AQYJ01000027_gene1743 4.21e-94 285.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,465N4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system znuC GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363 - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934 ABC_tran k59_116005_3 743720.Psefu_4318 1.22e-59 189.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,1YXG7@136845|Pseudomonas putida group 1236|Gammaproteobacteria K Belongs to the Fur family zur - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_116005_4 266834.SMc04245 6.29e-82 258.0 COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,2TVXP@28211|Alphaproteobacteria,4B89M@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC-type Zn2 transport system, periplasmic component surface adhesin znuA - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_90210_1 933262.AXAM01000015_gene85 6.48e-118 346.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2MHYU@213118|Desulfobacterales 28221|Deltaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_180955_1 580332.Slit_0896 1.12e-65 211.0 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1Q14J@1224|Proteobacteria,2W9SH@28216|Betaproteobacteria,44WFR@713636|Nitrosomonadales 28216|Betaproteobacteria H TOBE domain - - - ko:K02019 - - - - ko00000,ko03000 - - - TOBE k59_180955_2 270374.MELB17_02520 1.03e-28 112.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,4675T@72275|Alteromonadaceae 1236|Gammaproteobacteria P molybdenum ABC transporter, periplasmic modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_167838_1 1049564.TevJSym_ad01690 3.57e-54 176.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1J54R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm k59_167838_2 1049564.TevJSym_ad01700 2.49e-44 150.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1J5R7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB k59_31788_1 1387312.BAUS01000004_gene1448 1.92e-99 298.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2VP54@28216|Betaproteobacteria,2KM8U@206350|Nitrosomonadales 206350|Nitrosomonadales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_173996_1 859657.RPSI07_2279 4.13e-36 134.0 COG1413@1|root,COG1413@2|Bacteria,1NUN2@1224|Proteobacteria,2VMQF@28216|Betaproteobacteria,1KB9X@119060|Burkholderiaceae 28216|Betaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2 k59_5280_1 859657.RPSI07_mp0179 7.87e-138 404.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VH71@28216|Betaproteobacteria,1K3ER@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family vdh - 1.2.1.67 ko:K21802 ko00627,ko01120,map00627,map01120 - R05699 RC00075 ko00000,ko00001,ko01000 - - - Aldedh k59_193807_1 571.MC52_20680 3.8e-52 181.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,1RNBP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage protein gp29 - - - - - - - - - - - - DUF935 k59_173997_1 1298608.JCM18900_12862 1.14e-23 101.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,3NR8W@468|Moraxellaceae 1236|Gammaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_173997_2 1122194.AUHU01000002_gene2547 9.07e-15 73.9 COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,1RQA9@1236|Gammaproteobacteria,46734@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_5283_1 335543.Sfum_3243 3.04e-23 101.0 COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42SJA@68525|delta/epsilon subdivisions 1224|Proteobacteria T histidine kinase, dimerisation and phosphoacceptor region - - - - - - - - - - - - HATPase_c,HisKA_3,PAS,PAS_4,PAS_9 k59_25686_1 1121935.AQXX01000131_gene2796 2.02e-45 150.0 2FCGX@1|root,344KC@2|Bacteria,1P0MG@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_25686_2 1157708.KB907450_gene6330 4.17e-100 295.0 COG3023@1|root,COG3023@2|Bacteria,1RJJT@1224|Proteobacteria,2VVER@28216|Betaproteobacteria,4AHVK@80864|Comamonadaceae 28216|Betaproteobacteria V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - - - - - - - - - - - Amidase_2 k59_102837_1 502025.Hoch_1413 1.16e-145 431.0 COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria,2Z20S@29|Myxococcales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_5287_1 1265505.ATUG01000003_gene725 9.01e-25 102.0 COG2427@1|root,COG2427@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1641) - - - - - - - - - - - - DUF1641 k59_174001_2 426117.M446_0273 8.44e-20 84.3 COG0607@1|root,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - Phosphonate-bd,Rhodanese k59_25689_1 880072.Desac_0501 2.89e-101 315.0 COG2202@1|root,COG2204@1|root,COG3290@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_12689_1 279714.FuraDRAFT_0923 7.12e-51 170.0 COG1309@1|root,COG1309@2|Bacteria,1RGQQ@1224|Proteobacteria,2VR87@28216|Betaproteobacteria,2KT11@206351|Neisseriales 206351|Neisseriales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_25690_2 1163407.UU7_00650 1.36e-34 125.0 COG0732@1|root,COG0732@2|Bacteria,1NFDW@1224|Proteobacteria,1SZZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria V restriction modification system DNA specificity - - - - - - - - - - - - Methylase_S k59_141941_1 1449346.JQMO01000003_gene6124 0.000516 47.8 COG3291@1|root,COG3291@2|Bacteria,2GKNE@201174|Actinobacteria 201174|Actinobacteria NU Collagenase - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - PKD,PPC,Peptidase_M9,Peptidase_M9_N k59_83840_2 398578.Daci_2948 3.59e-152 457.0 COG0457@1|root,COG1565@1|root,COG0457@2|Bacteria,COG1565@2|Bacteria,1NWVK@1224|Proteobacteria 1224|Proteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_5288_1 1120977.JHUX01000003_gene1292 6.37e-68 221.0 COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,1RY26@1236|Gammaproteobacteria,3NJHX@468|Moraxellaceae 1236|Gammaproteobacteria E Glycosyl transferase family, helical bundle domain ybiB GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - - - - - - - - - - Glycos_trans_3N,Glycos_transf_3 k59_5288_2 765910.MARPU_03115 1.46e-18 86.7 2E2KC@1|root,32XPP@2|Bacteria,1R4ZI@1224|Proteobacteria,1RZVK@1236|Gammaproteobacteria,1WWI9@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_161761_2 267608.RSc3236 6.54e-60 191.0 COG2197@1|root,COG2197@2|Bacteria,1NA3X@1224|Proteobacteria,2VWX0@28216|Betaproteobacteria,1KAW7@119060|Burkholderiaceae 28216|Betaproteobacteria KT phage-related functions and prophages - - - - - - - - - - - - HNH_3 k59_135895_2 879212.DespoDRAFT_01537 1.69e-17 80.9 COG0711@1|root,COG0711@2|Bacteria,1NA9K@1224|Proteobacteria,42VN2@68525|delta/epsilon subdivisions,2WR8C@28221|Deltaproteobacteria,2MKBA@213118|Desulfobacterales 28221|Deltaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpX - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_25692_1 748658.KB907321_gene848 6.41e-44 146.0 COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,1RRGB@1236|Gammaproteobacteria,1X08N@135613|Chromatiales 135613|Chromatiales K Bacterial regulatory protein, arsR family - - - - - - - - - - - - MarR_2 k59_25692_2 998674.ATTE01000001_gene589 1.54e-53 192.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_199945_1 56780.SYN_00126 1.05e-132 388.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MR4Y@213462|Syntrophobacterales 28221|Deltaproteobacteria NU Type IV secretion-system coupling protein DNA-binding domain pilT1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_25696_1 1158760.AQXP01000053_gene1523 4.74e-58 201.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WXKY@135613|Chromatiales 135613|Chromatiales T PFAM chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,HAMP,MCPsignal,NIT,PAS_3,PAS_8,PAS_9 k59_161767_1 1121403.AUCV01000026_gene2331 8.94e-41 143.0 COG1102@1|root,COG1102@2|Bacteria,1R82J@1224|Proteobacteria,42M5Z@68525|delta/epsilon subdivisions,2WMEJ@28221|Deltaproteobacteria,2MI55@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_180978_1 439235.Dalk_2357 3.26e-106 318.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_174026_1 439235.Dalk_4550 3.04e-05 54.3 COG3055@1|root,COG3209@1|root,COG3055@2|Bacteria,COG3209@2|Bacteria,1NK1N@1224|Proteobacteria 1224|Proteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - Laminin_G_3 k59_102858_3 1499967.BAYZ01000095_gene4055 9.75e-62 194.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - 2.3.1.82 ko:K18815 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_51811_1 935948.KE386495_gene1643 5.49e-21 93.6 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales 186801|Clostridia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_51811_2 521098.Aaci_0301 3.12e-19 89.4 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,278UP@186823|Alicyclobacillaceae 91061|Bacilli NU type II secretion system protein E pilB - - ko:K02243,ko:K02652 - M00429 - - ko00000,ko00002,ko02035,ko02044 3.A.14.1,3.A.15.2 - - T2SSE,T2SSE_N k59_162028_1 1040989.AWZU01000112_gene4443 3.49e-82 255.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JX5H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_5581_2 859657.RPSI07_0567 1.09e-92 285.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1K0VU@119060|Burkholderiaceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_18856_1 1166130.H650_11985 7.08e-126 374.0 COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,1RY7N@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT GfdT protein - - - - - - - - - - - - FIST,FIST_C k59_25847_1 247633.GP2143_05020 2.93e-24 103.0 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria,1J6QJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_25847_2 582744.Msip34_2621 2.25e-98 312.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VN53@28216|Betaproteobacteria,2KM14@206350|Nitrosomonadales 206350|Nitrosomonadales I PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding k59_25847_3 378806.STAUR_0147 1.24e-79 250.0 COG2175@1|root,COG2175@2|Bacteria 2|Bacteria Q oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - - - - - - - - - - AMP-binding,TauD k59_12926_1 1049564.TevJSym_ag00660 2.97e-289 815.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM von Willebrand factor type A - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - - k59_12926_2 768671.ThimaDRAFT_1450 9.82e-41 147.0 COG2854@1|root,COG2854@2|Bacteria,1NUHS@1224|Proteobacteria,1SN8R@1236|Gammaproteobacteria,1X0Q3@135613|Chromatiales 135613|Chromatiales Q MlaC protein - - - - - - - - - - - - MlaC k59_12926_3 768671.ThimaDRAFT_1449 2.3e-41 144.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1WY72@135613|Chromatiales 135613|Chromatiales O TIGRFAM clan AA aspartic protease, TIGR02281 family - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_103075_1 1123371.ATXH01000001_gene1266 3.38e-52 174.0 COG0189@1|root,COG0189@2|Bacteria,2GHFX@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_103075_2 1121405.dsmv_3672 1.71e-05 46.6 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - AIRC,GARS_A,GARS_C,GARS_N k59_25849_1 395493.BegalDRAFT_2355 7e-13 65.1 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,460Q7@72273|Thiotrichales 72273|Thiotrichales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_25849_2 243233.MCA1045 9.6e-60 189.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XF4V@135618|Methylococcales 135618|Methylococcales I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_46556_1 1120947.ATUX01000006_gene333 7.4e-33 133.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4D3AQ@85005|Actinomycetales 201174|Actinobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_27217_1 1121456.ATVA01000016_gene2013 5.24e-27 100.0 COG1917@1|root,COG1917@2|Bacteria,1N2Q9@1224|Proteobacteria,42UBE@68525|delta/epsilon subdivisions,2WQDI@28221|Deltaproteobacteria,2MCGD@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Cupin 2, conserved barrel - - - - - - - - - - - - AraC_binding,Cupin_2 k59_27217_2 768704.Desmer_1589 1.19e-10 64.7 COG0348@1|root,COG0348@2|Bacteria,1V312@1239|Firmicutes,25BT7@186801|Clostridia,263HZ@186807|Peptococcaceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5 k59_7755_1 1121396.KB893100_gene4319 3.4e-153 473.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_7,Pyr_redox_2 k59_118027_1 1049564.TevJSym_aa01160 1.04e-157 450.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1J57M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_118027_2 713586.KB900536_gene619 4.15e-77 239.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_118027_6 1049564.TevJSym_aa01200 1.18e-20 89.0 COG1261@1|root,COG1261@2|Bacteria,1N1SA@1224|Proteobacteria,1S8SQ@1236|Gammaproteobacteria,1J6IH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly flgA - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_40196_1 443144.GM21_1977 5.8e-62 193.0 COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,42U19@68525|delta/epsilon subdivisions,2WR05@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM thioesterase superfamily - - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT k59_72492_1 498761.HM1_2750 1.4e-73 233.0 COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia 186801|Clostridia E LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_169911_1 1121921.KB898708_gene1396 1.18e-17 84.7 COG0642@1|root,COG0642@2|Bacteria,1MURQ@1224|Proteobacteria,1RP9C@1236|Gammaproteobacteria,2PN31@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T PAS domain fleS - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_8 k59_169911_2 557598.LHK_02363 1.37e-05 47.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KQ9V@206351|Neisseriales 206351|Neisseriales T Sigma-54 interaction domain - - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_111474_1 1049564.TevJSym_ai00820 1.12e-26 103.0 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_111474_2 1049564.TevJSym_bj00160 4.95e-100 320.0 COG3420@1|root,COG3420@2|Bacteria,1QWWH@1224|Proteobacteria 1224|Proteobacteria P Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Beta_helix,NosD,W_rich_C k59_111474_3 1049564.TevJSym_ai00870 6.75e-17 79.7 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1J4VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_150457_1 1049564.TevJSym_ax00340 8.16e-97 283.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_131043_1 1121405.dsmv_3219 7.39e-68 219.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria,2MHR6@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_98306_1 339670.Bamb_6432 9.77e-27 101.0 COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2VU5B@28216|Betaproteobacteria,1K8GH@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 k59_91997_1 75379.Tint_0777 6.07e-112 339.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,1KJGK@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_72496_1 177437.HRM2_05410 3.36e-69 220.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,42NSB@68525|delta/epsilon subdivisions,2WIKP@28221|Deltaproteobacteria,2MJ70@213118|Desulfobacterales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_85462_3 1120970.AUBZ01000021_gene3248 4.04e-44 153.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,46768@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) ltg - - - - - - - - - - - DUF4124,SLT k59_85462_4 983545.Glaag_0853 3.89e-08 59.7 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,464S6@72275|Alteromonadaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_143945_1 1249627.D779_0261 4.12e-75 226.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales 135613|Chromatiales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_7762_1 319224.Sputcn32_0178 9.73e-25 100.0 COG0582@1|root,COG0582@2|Bacteria,1QRWN@1224|Proteobacteria,1SVK3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_79280_1 519989.ECTPHS_13927 1.45e-89 276.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWPX@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_176225_1 1316932.MHH_c19710 2.31e-91 276.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria,1Y7KV@135625|Pasteurellales 135625|Pasteurellales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_13988_1 1249627.D779_0634 8.89e-147 427.0 COG0247@1|root,COG0247@2|Bacteria,1QV1F@1224|Proteobacteria,1T3FB@1236|Gammaproteobacteria,1X2VQ@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_8 k59_137247_1 880072.Desac_0968 1.25e-14 73.2 COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42SR1@68525|delta/epsilon subdivisions,2WP5P@28221|Deltaproteobacteria,2MQKJ@213462|Syntrophobacterales 28221|Deltaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_137247_2 335543.Sfum_0510 1.42e-35 128.0 COG0500@1|root,COG2226@2|Bacteria,1R9JW@1224|Proteobacteria,42M76@68525|delta/epsilon subdivisions,2WK4P@28221|Deltaproteobacteria,2MQVD@213462|Syntrophobacterales 28221|Deltaproteobacteria Q Putative methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 k59_46565_1 1049564.TevJSym_ax00240 5.05e-119 375.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria,1JC1F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - 4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_156804_2 1049564.TevJSym_ad01640 1.89e-60 191.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1J6GH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - ko:K02200 - - - - ko00000 - - - CcmH k59_65994_1 1121405.dsmv_1011 9.8e-10 64.3 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2MPS7@213118|Desulfobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_33673_1 1121935.AQXX01000096_gene2550 8.37e-109 327.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,1S09Z@1236|Gammaproteobacteria,1XP1M@135619|Oceanospirillales 135619|Oceanospirillales KL DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_27232_1 1266909.AUAG01000063_gene1806 4.85e-126 373.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales 135613|Chromatiales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_143948_1 318996.AXAZ01000025_gene2362 1.89e-35 135.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,3JT38@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,rve k59_143948_2 398767.Glov_2865 7.01e-50 166.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_59641_1 335543.Sfum_0813 7.24e-74 236.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,42N09@68525|delta/epsilon subdivisions,2WIRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_33677_1 439235.Dalk_3802 9.82e-113 331.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria,2MK8B@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_104880_2 1386089.N865_00545 1.06e-19 90.5 COG0791@1|root,COG0791@2|Bacteria,2IFT3@201174|Actinobacteria,4FF29@85021|Intrasporangiaceae 201174|Actinobacteria M NlpC/P60 family - - 3.4.14.13 ko:K20742 - - - - ko00000,ko01000,ko01002 - - - NLPC_P60 k59_104880_3 1131269.AQVV01000003_gene672 2.68e-05 45.1 COG0119@1|root,COG0119@2|Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_124509_1 317936.Nos7107_2006 3.89e-83 254.0 COG0667@1|root,COG0667@2|Bacteria,1G1J4@1117|Cyanobacteria,1HM3F@1161|Nostocales 1117|Cyanobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_98317_1 195250.CM001776_gene952 8.82e-13 68.2 COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus 1117|Cyanobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_40226_1 589865.DaAHT2_0823 1.36e-70 239.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,43D5V@68525|delta/epsilon subdivisions,2X8CM@28221|Deltaproteobacteria,2MPN0@213118|Desulfobacterales 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - FeS,Fer2_4,Fer4,Fer4_20,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,Pyr_redox_2 k59_143964_1 247490.KSU1_D0002 1.74e-23 97.1 COG3065@1|root,COG3065@2|Bacteria 2|Bacteria M identical protein binding slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - ko:K07285 - - - - ko00000 - - - Slp k59_169943_1 933262.AXAM01000053_gene2709 2.25e-146 432.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MICJ@213118|Desulfobacterales 28221|Deltaproteobacteria I TIGRFAM methylmalonyl-CoA mutase, large subunit - - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_59650_1 1499967.BAYZ01000056_gene4918 1.17e-70 228.0 COG3829@1|root,COG3829@2|Bacteria,2NQFX@2323|unclassified Bacteria 2|Bacteria KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_85486_2 1049564.TevJSym_aj00280 5.48e-74 230.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1J4D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_60020_2 1348114.OM33_21730 2.63e-49 161.0 COG2303@1|root,COG2303@2|Bacteria,1RH5U@1224|Proteobacteria,1S60X@1236|Gammaproteobacteria,2Q2WF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - - k59_92486_1 156889.Mmc1_3409 2.05e-45 167.0 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG2202@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,1NC9X@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_1 k59_14344_2 323261.Noc_0414 1.52e-26 100.0 COG5450@1|root,COG5450@2|Bacteria,1N76R@1224|Proteobacteria,1SD4N@1236|Gammaproteobacteria,1X1CI@135613|Chromatiales 135613|Chromatiales K Bacterial antitoxin of type II TA system, VapB - - - - - - - - - - - - VapB_antitoxin k59_14344_3 1286106.MPL1_12703 1.44e-53 172.0 COG1487@1|root,COG1487@2|Bacteria,1RHIX@1224|Proteobacteria,1S6AM@1236|Gammaproteobacteria,462PP@72273|Thiotrichales 72273|Thiotrichales S PIN domain - - - - - - - - - - - - PIN k59_14344_6 1049564.TevJSym_at00520 6.97e-33 116.0 COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria,1J6Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S YcgL domain-containing protein ycgL - - ko:K09902 - - - - ko00000 - - - YcgL k59_21161_1 1232453.BAIF02000053_gene912 1.72e-23 100.0 COG2020@1|root,COG2020@2|Bacteria,1V3IZ@1239|Firmicutes,24FW3@186801|Clostridia,26BTS@186813|unclassified Clostridiales 186801|Clostridia O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - DUF218,PEMT k59_98650_1 720554.Clocl_2736 2.88e-35 124.0 COG4639@1|root,COG4639@2|Bacteria,1V3QX@1239|Firmicutes,24NUB@186801|Clostridia,3WK3J@541000|Ruminococcaceae 186801|Clostridia S AAA domain - - - - - - - - - - - - AAA_33 k59_98650_2 717773.Thicy_1386 5.33e-24 92.8 COG1396@1|root,COG1396@2|Bacteria,1NNTN@1224|Proteobacteria,1SIW9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_79738_1 1049564.TevJSym_cb00050 1.35e-124 379.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_79738_3 572477.Alvin_1907 7.26e-57 181.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1WY9Z@135613|Chromatiales 135613|Chromatiales I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_131490_1 859657.RPSI07_2273 9.11e-08 53.1 COG5351@1|root,COG5351@2|Bacteria,1R3ZF@1224|Proteobacteria,2VS1K@28216|Betaproteobacteria,1K98W@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2169) - - - - - - - - - - - - DUF2169 k59_131490_2 529507.PMI0754 1.14e-58 200.0 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,1S1M0@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_131490_3 215803.DB30_4823 3.9e-41 148.0 COG1475@1|root,COG1475@2|Bacteria,1RIT4@1224|Proteobacteria,4382V@68525|delta/epsilon subdivisions,2X3CV@28221|Deltaproteobacteria,2YVGI@29|Myxococcales 28221|Deltaproteobacteria K Domain of unknown function (DUF4150) - - - - - - - - - - - - DUF4150 k59_92494_1 309799.DICTH_0721 9.79e-84 273.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_202681_3 1219077.VAZ01S_017_00940 5.52e-46 153.0 2BUA7@1|root,32PJR@2|Bacteria,1RJ7R@1224|Proteobacteria,1S8H6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DoxX-like family - - - - - - - - - - - - DoxX_3 k59_202681_4 631362.Thi970DRAFT_03888 1.21e-29 112.0 2AJ09@1|root,319IA@2|Bacteria,1N2QV@1224|Proteobacteria,1SABP@1236|Gammaproteobacteria,1WZ9I@135613|Chromatiales 135613|Chromatiales S PFAM Plasmid pRiA4b ORF-3-like protein - - - - - - - - - - - - PRiA4_ORF3 k59_202681_6 768671.ThimaDRAFT_2930 1.95e-24 101.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1S1WF@1236|Gammaproteobacteria,1X0A4@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_202681_8 765912.Thimo_0365 3.41e-18 82.4 COG2267@1|root,COG2267@2|Bacteria,1QUAA@1224|Proteobacteria,1T1RD@1236|Gammaproteobacteria,1WYZI@135613|Chromatiales 135613|Chromatiales I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_131494_1 335543.Sfum_2063 2.66e-57 201.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MR7V@213462|Syntrophobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_137564_2 879212.DespoDRAFT_00073 3.24e-104 306.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2MJ0K@213118|Desulfobacterales 28221|Deltaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1434_1 1121405.dsmv_2223 2.77e-137 392.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2WKJ3@28221|Deltaproteobacteria,2MIDE@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM ABC transporter related lolD-2 - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1434_2 1121405.dsmv_2224 3.83e-42 158.0 COG0577@1|root,COG2234@1|root,COG0577@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,PA,Peptidase_M28 k59_60032_1 96561.Dole_2491 8.75e-72 228.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_157205_1 118168.MC7420_5670 3.4e-79 248.0 COG3875@1|root,COG3875@2|Bacteria,1G82E@1117|Cyanobacteria,1HDBH@1150|Oscillatoriales 1117|Cyanobacteria S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 k59_53434_1 1121405.dsmv_1451 4.42e-34 124.0 COG0489@1|root,COG0489@2|Bacteria,1R6AC@1224|Proteobacteria,42NTJ@68525|delta/epsilon subdivisions,2WM95@28221|Deltaproteobacteria,2MJ5Z@213118|Desulfobacterales 28221|Deltaproteobacteria D protein tyrosine kinase activity - - - - - - - - - - - - - k59_176710_1 525897.Dbac_1840 9.43e-88 275.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_185803_1 644282.Deba_1961 3.89e-84 265.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_191811_1 314278.NB231_06306 3.55e-114 343.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales 135613|Chromatiales H TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_191811_2 290397.Adeh_0828 2.89e-34 122.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2WNA5@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_107634_1 1121403.AUCV01000045_gene1140 1.32e-62 197.0 COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,42SKM@68525|delta/epsilon subdivisions,2WV6M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF1287) - - - ko:K09974 - - - - ko00000 - - - DUF1287 k59_107634_2 471852.Tcur_3248 1.05e-12 63.5 COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4EJSG@85012|Streptosporangiales 201174|Actinobacteria FG HIT domain hit - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_29700_1 96561.Dole_1849 2.75e-144 422.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,2MIAG@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_121106_1 765914.ThisiDRAFT_1514 2.47e-97 298.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_55195_5 1565129.JSFF01000006_gene2475 3.94e-58 201.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,2QAHI@267890|Shewanellaceae 1236|Gammaproteobacteria U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_172264_1 1168065.DOK_02511 1.14e-117 353.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,1J50K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar hook protein FlgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_172264_2 1049564.TevJSym_aa01260 3.83e-25 99.4 COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,1RNVX@1236|Gammaproteobacteria,1J5TK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N flagellar basal body flgF - - ko:K02391 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_204685_4 1089551.KE386572_gene1953 5.77e-133 399.0 COG2242@1|root,COG2242@2|Bacteria,1PEB4@1224|Proteobacteria,2TXFJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - - k59_204685_5 744872.Spica_0007 1.05e-05 53.9 COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes 203691|Spirochaetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_204685_6 1249627.D779_3691 6.01e-112 332.0 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,1RMV0@1236|Gammaproteobacteria,1WZHK@135613|Chromatiales 135613|Chromatiales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_179071_1 768671.ThimaDRAFT_1475 9.6e-18 88.6 COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,1RZMQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_29701_1 472759.Nhal_1154 2.89e-97 311.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WX0W@135613|Chromatiales 135613|Chromatiales N transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_68876_3 1049564.TevJSym_ah00200 5.07e-245 681.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1J4TM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_68876_4 95619.PM1_0200465 1.88e-27 113.0 COG3152@1|root,COG3152@2|Bacteria,1NBFY@1224|Proteobacteria,1SCJ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_68876_6 1049564.TevJSym_ar00390 2.13e-11 74.7 COG0666@1|root,COG0790@1|root,COG0666@2|Bacteria,COG0790@2|Bacteria,1N6ZB@1224|Proteobacteria 1224|Proteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_192060_2 1049564.TevJSym_ar00540 2.92e-101 312.0 COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,1J4RT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_95743_1 484019.THA_1190 1.08e-10 66.6 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2GCE3@200918|Thermotogae 200918|Thermotogae NT Signal transducing histidine kinase, homodimeric - GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k59_36811_2 1246445.ANAY01000010_gene1214 2.59e-08 57.8 COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4EIGT@85012|Streptosporangiales 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_139905_1 225117.XP_009366572.1 4.71e-21 91.3 2CV7H@1|root,2RRGK@2759|Eukaryota,383A9@33090|Viridiplantae,3GS0R@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_172457_1 1122604.JONR01000033_gene24 1.02e-16 77.4 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales 135614|Xanthomonadales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_172457_2 1049564.TevJSym_as00370 1.85e-104 306.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1J5SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212 Ham1p_like k59_172457_3 563040.Saut_1275 1.91e-178 520.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Sulfatase eptA - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_172457_4 1283300.ATXB01000001_gene2201 9.67e-52 175.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component gtrB - - - - - - - - - - - DctM k59_146774_1 203119.Cthe_2141 2.81e-168 483.0 COG0232@1|root,COG0232@2|Bacteria,1UYDF@1239|Firmicutes,24CBV@186801|Clostridia,3WJ29@541000|Ruminococcaceae 186801|Clostridia F Metal dependent phosphohydrolases with conserved 'HD' motif. - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_146774_2 1280694.AUJQ01000007_gene1082 2.11e-06 53.9 COG0265@1|root,COG0265@2|Bacteria,1UZ8K@1239|Firmicutes,24N2F@186801|Clostridia 186801|Clostridia O Trypsin-like peptidase domain - - - - - - - - - - - - Cu_amine_oxidN1,DUF5050,RsgI_N,Trypsin_2 k59_16557_1 317025.Tcr_0040 1.76e-66 205.0 COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria,1S40B@1236|Gammaproteobacteria,460XE@72273|Thiotrichales 72273|Thiotrichales P Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide cynS - 4.2.1.104 ko:K01725 ko00910,map00910 - R03546,R10079 RC00952 ko00000,ko00001,ko01000 - - - Cyanate_lyase k59_16557_2 1158762.KB898046_gene547 8.3e-105 312.0 COG1116@1|root,COG1116@2|Bacteria,1R8N0@1224|Proteobacteria,1RYBX@1236|Gammaproteobacteria,1WY77@135613|Chromatiales 135613|Chromatiales P ABC transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_16557_3 317025.Tcr_0033 3.73e-147 425.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RYYZ@1236|Gammaproteobacteria,461TG@72273|Thiotrichales 72273|Thiotrichales P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_29997_1 519989.ECTPHS_07027 1.07e-60 194.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1WW6U@135613|Chromatiales 135613|Chromatiales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_179331_1 1049564.TevJSym_af00400 7.04e-97 291.0 COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1J50Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdA GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0019438,GO:0019464,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045250,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0065007,GO:0065008,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385 Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_192067_1 1158756.AQXQ01000012_gene2038 3.07e-84 260.0 COG0540@1|root,COG0540@2|Bacteria,1R3Q5@1224|Proteobacteria,1RYCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family - - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_192067_2 857087.Metme_3219 4.2e-07 50.4 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales 135618|Methylococcales F PFAM Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_3549_5 1122201.AUAZ01000004_gene3398 6.91e-78 234.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,1SA7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_172462_2 316274.Haur_3400 0.000153 47.4 COG0406@1|root,COG0406@2|Bacteria,2G73Q@200795|Chloroflexi,37737@32061|Chloroflexia 32061|Chloroflexia G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_146778_1 1380391.JIAS01000014_gene1945 1.95e-175 499.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQCM@204441|Rhodospirillales 204441|Rhodospirillales I Belongs to the thiolase family - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_75030_1 316274.Haur_3999 5.06e-11 63.9 COG0581@1|root,COG0581@2|Bacteria,2G6BI@200795|Chloroflexi,374ZR@32061|Chloroflexia 32061|Chloroflexia P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_75030_2 1550073.JROH01000011_gene2036 1.04e-26 106.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,2JZZN@204457|Sphingomonadales 204457|Sphingomonadales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_179335_1 326297.Sama_3523 4.21e-68 223.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,2QB24@267890|Shewanellaceae 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,FAD_binding_3,NAD_binding_8 k59_121475_1 1049564.TevJSym_am00140 2.59e-49 163.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1J690@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Cytochrome C biogenesis protein transmembrane region braZ - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_82084_1 35754.JNYJ01000002_gene6755 2.27e-107 319.0 COG0524@1|root,COG0524@2|Bacteria,2HU2B@201174|Actinobacteria,4DAJP@85008|Micromonosporales 201174|Actinobacteria G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_139920_1 511145.b3706 2.32e-107 326.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,3XNA1@561|Escherichia 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_192070_1 1439940.BAY1663_04082 2.17e-24 105.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RMQ0@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs HA62_01445 - - - - - - - - - - - Aminotran_1_2,GntR k59_186143_1 1049564.TevJSym_an00050 9.71e-55 191.0 COG3221@1|root,COG4191@1|root,COG3221@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1J5WY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain fixL - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_128087_1 1278073.MYSTI_04523 2.29e-101 328.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,2YXV4@29|Myxococcales 28221|Deltaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_107968_1 589865.DaAHT2_2485 7.89e-77 246.0 COG5598@1|root,COG5598@2|Bacteria 2|Bacteria H trimethylamine methyltransferase mttB3 - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_165942_1 997346.HMPREF9374_0037 1.63e-32 122.0 COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4HAE2@91061|Bacilli,27BKT@186824|Thermoactinomycetaceae 91061|Bacilli C Electron transfer flavoprotein domain etfA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_95761_1 1214065.BAGV01000045_gene2030 2.55e-75 233.0 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - AHH,PAAR_motif,RHS,RHS_repeat k59_23784_1 292415.Tbd_2695 3.56e-30 115.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,1KRWY@119069|Hydrogenophilales 119069|Hydrogenophilales O Ribosomal RNA adenine dimethylase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_23784_2 1049564.TevJSym_bt00160 0.000592 41.6 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,1S7F3@1236|Gammaproteobacteria,1JAX1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_114216_1 439235.Dalk_2355 4.67e-05 43.9 COG1633@1|root,COG1633@2|Bacteria,1RGYD@1224|Proteobacteria,42T5E@68525|delta/epsilon subdivisions,2WPKD@28221|Deltaproteobacteria,2MKDK@213118|Desulfobacterales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_114216_2 573370.DMR_17610 4.16e-72 220.0 COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Desulfoferrodoxin ferrous iron-binding region dfx - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrod_N,Desulfoferrodox k59_88365_1 1047013.AQSP01000070_gene35 9.17e-55 172.0 COG3093@1|root,COG3093@2|Bacteria 2|Bacteria K addiction module antidote protein HigA vapL - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3,HTH_31 k59_88365_2 1047013.AQSP01000070_gene36 3.64e-55 172.0 COG3549@1|root,COG3549@2|Bacteria 2|Bacteria S RelE-like toxin of type II toxin-antitoxin system HigB - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin k59_36835_1 706587.Desti_1056 7.07e-99 301.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Pyridoxal-dependent decarboxylase - - 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - - EF-hand_7,Pyridoxal_deC k59_82089_1 439235.Dalk_4864 1.78e-32 116.0 2AT6X@1|root,31IPI@2|Bacteria,1RHW1@1224|Proteobacteria,42SHT@68525|delta/epsilon subdivisions,2WP67@28221|Deltaproteobacteria,2MK8G@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_62829_1 261292.Nit79A3_0032 8.93e-68 223.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2VKCX@28216|Betaproteobacteria,3722M@32003|Nitrosomonadales 28216|Betaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_100984_1 1123393.KB891333_gene2618 3.21e-96 290.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1KRAI@119069|Hydrogenophilales 119069|Hydrogenophilales C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_192073_1 1266909.AUAG01000001_gene1592 1.58e-14 73.9 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Type I secretion membrane fusion protein, HlyD hlyD - - ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_192073_2 1121935.AQXX01000111_gene5832 1.05e-109 338.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XIJU@135619|Oceanospirillales 135619|Oceanospirillales V (ABC) transporter - - - ko:K11004,ko:K13409 ko02010,ko03070,ko04626,ko05133,map02010,map03070,map04626,map05133 M00325,M00339,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2,3.A.1.110 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_107974_1 1049564.TevJSym_ad00140 1.88e-68 208.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria,1J6ER@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional VL23_01195 - - - - - - - - - - - MerR_1 k59_204912_1 309803.CTN_0742 5.45e-42 149.0 COG0157@1|root,COG0157@2|Bacteria,2GC5R@200918|Thermotogae 200918|Thermotogae H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1645 QRPTase_C,QRPTase_N k59_146793_1 1121396.KB892910_gene4172 2.51e-72 231.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_153129_1 1283300.ATXB01000002_gene2944 1.02e-27 113.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1XDVC@135618|Methylococcales 135618|Methylococcales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_107976_1 933262.AXAM01000010_gene1371 4.31e-27 108.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_128097_2 1125863.JAFN01000001_gene2152 9.36e-26 104.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_114218_1 1128421.JAGA01000004_gene2609 1.05e-168 482.0 COG2224@1|root,COG2224@2|Bacteria 2|Bacteria C isocitrate lyase activity aceA GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJN746.PP_4116,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880 ICL k59_153131_1 526222.Desal_1367 2.51e-50 181.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2WJKV@28221|Deltaproteobacteria,2M7VM@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_159884_2 314270.RB2083_313 3.34e-20 84.0 2DRKG@1|root,33C62@2|Bacteria,1NK15@1224|Proteobacteria,2UJWT@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_109969_1 335543.Sfum_2687 4.99e-103 314.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales 28221|Deltaproteobacteria F PFAM Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_142018_1 443152.MDG893_08871 4.53e-104 321.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_116079_1 644282.Deba_1277 3.35e-40 146.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria 28221|Deltaproteobacteria BQ PFAM Histone deacetylase - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_181031_2 1000565.METUNv1_00709 1.35e-55 179.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VRCR@28216|Betaproteobacteria,2KW89@206389|Rhodocyclales 206389|Rhodocyclales O Bacterial protein of unknown function (DUF899) - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_181031_4 1049564.TevJSym_bb00270 5.64e-164 468.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1J4XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Uncharacterized conserved protein (DUF2075) - - - - - - - - - - - - AAA_22 k59_57222_1 1304883.KI912532_gene809 2.39e-168 480.0 COG3454@1|root,COG3454@2|Bacteria,1MV7H@1224|Proteobacteria,2VMPU@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphonate metabolism protein PhnM phnM - 3.6.1.63 ko:K06162 ko00440,map00440 - R10186 RC00002 ko00000,ko00001,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_57222_2 1218076.BAYB01000030_gene4941 2.47e-18 84.0 COG4778@1|root,COG4778@2|Bacteria,1MUPB@1224|Proteobacteria,2VQ6N@28216|Betaproteobacteria,1K1U4@119060|Burkholderiaceae 28216|Betaproteobacteria P phosphonate C-P lyase system protein PhnL phnL - 2.7.8.37 ko:K05780 ko00440,map00440 - R10185 RC00005,RC00063 ko00000,ko00001,ko01000 - - - ABC_tran k59_161848_1 1255043.TVNIR_2988 2.33e-105 317.0 28K6U@1|root,2Z9V7@2|Bacteria,1MYVN@1224|Proteobacteria,1S0GU@1236|Gammaproteobacteria,1WW9K@135613|Chromatiales 135613|Chromatiales S TIGRFAM carboxysome shell carbonic anhydrase - - - - - - - - - - - - CsoSCA k59_90360_2 1004149.AFOE01000010_gene2493 1.73e-10 65.5 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1HYE4@117743|Flavobacteriia 976|Bacteroidetes T Universal stress protein - - - - - - - - - - - - Usp k59_57224_1 1392838.AWNM01000004_gene1766 5.99e-73 225.0 28IDB@1|root,2Z8FM@2|Bacteria,1R5Q5@1224|Proteobacteria,2VKNK@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_57224_3 349521.HCH_05660 1.01e-38 134.0 29R08@1|root,30C1B@2|Bacteria,1RGEJ@1224|Proteobacteria,1SPY0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_57224_4 1123368.AUIS01000006_gene534 1.24e-30 114.0 2DBUA@1|root,2ZB4Z@2|Bacteria,1PB9S@1224|Proteobacteria,1SA2F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_57228_1 1415774.U728_1379 1.93e-07 54.3 COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae 186801|Clostridia C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_83933_1 571.MC52_27220 0.000102 52.8 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase baeS GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0019538,GO:0023014,GO:0023052,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_18686_1 765913.ThidrDRAFT_3516 1.92e-116 347.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales 135613|Chromatiales S Methyltransferase - - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_18686_2 765911.Thivi_3282 2.22e-181 519.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WVY9@135613|Chromatiales 135613|Chromatiales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_18686_4 1114922.CIFAM_02_01540 4.67e-06 48.1 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,3WVS5@544|Citrobacter 1236|Gammaproteobacteria I Coenzyme A transferase atoD - 2.8.3.8,2.8.3.9 ko:K01034 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_18686_5 748247.AZKH_p0588 1.7e-64 202.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VHFT@28216|Betaproteobacteria,2KVRM@206389|Rhodocyclales 206389|Rhodocyclales I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - 2.8.3.8,2.8.3.9 ko:K01034 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_116098_2 1121935.AQXX01000140_gene1049 5.15e-45 154.0 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_57236_2 502025.Hoch_0745 1.06e-33 130.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,42SZ0@68525|delta/epsilon subdivisions,2WPIR@28221|Deltaproteobacteria,2Z0J2@29|Myxococcales 28221|Deltaproteobacteria KL SNF2 family N-terminal domain - - - - - - - - - - - - DUF3883,Helicase_C,SNF2_N k59_154974_2 1249627.D779_3516 3.46e-189 539.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_206678_1 933262.AXAM01000018_gene999 6.25e-71 228.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MIN7@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_167909_1 1049564.TevJSym_bc00430 1.26e-91 291.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1J4Q5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_109984_1 1198232.CYCME_3036 8.73e-21 92.0 COG3843@1|root,COG3843@2|Bacteria,1QUDG@1224|Proteobacteria,1RSQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase k59_109984_2 76114.p2B19 1.64e-147 435.0 COG3505@1|root,COG3505@2|Bacteria,1MV1G@1224|Proteobacteria,2VH7W@28216|Betaproteobacteria,2KY0K@206389|Rhodocyclales 206389|Rhodocyclales U Type IV secretory system Conjugative DNA transfer - - - ko:K03205 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS-DNA_transf k59_5395_1 94122.Shewana3_0686 9.87e-51 170.0 COG4757@1|root,COG4757@2|Bacteria,1Q1V6@1224|Proteobacteria,1RT3H@1236|Gammaproteobacteria,2QE2A@267890|Shewanellaceae 1236|Gammaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_5395_2 457429.ABJI02000843_gene3311 1.15e-65 207.0 COG1309@1|root,COG1309@2|Bacteria,2HR0A@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator yxaF_2 - - - - - - - - - - - TetR_C_13,TetR_N k59_12786_1 631362.Thi970DRAFT_01611 1.59e-119 360.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_25776_1 396588.Tgr7_2229 1.09e-35 135.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales 135613|Chromatiales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_25776_2 1049564.TevJSym_be00160 1.01e-34 124.0 COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,1T2GY@1236|Gammaproteobacteria,1J6IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M TonB C terminal tolA - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C k59_116113_1 187272.Mlg_0224 5.53e-41 140.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_167915_1 1120953.AUBH01000004_gene2970 2.6e-15 80.9 COG1361@1|root,COG3637@1|root,COG5295@1|root,COG1361@2|Bacteria,COG3637@2|Bacteria,COG5295@2|Bacteria,1QVUF@1224|Proteobacteria,1T2J7@1236|Gammaproteobacteria,46DCC@72275|Alteromonadaceae 1236|Gammaproteobacteria MUW this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - - - - - - - - - - Cadherin,OmpA k59_109995_1 2340.JV46_19290 2.08e-142 419.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_193919_1 1279017.AQYJ01000029_gene3960 2.01e-111 350.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_193919_2 104623.Ser39006_02890 1.96e-36 138.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,404F7@613|Serratia 1236|Gammaproteobacteria L Phage integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase k59_206694_1 933262.AXAM01000023_gene658 4.13e-108 343.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_5407_1 1381123.AYOD01000015_gene2545 4.69e-90 273.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,43GV4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S PrpF protein fldA - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_5407_2 1232683.ADIMK_0091 1.17e-43 155.0 COG0583@1|root,COG0583@2|Bacteria,1Q531@1224|Proteobacteria,1RWPD@1236|Gammaproteobacteria,46BNP@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family fldY - - - - - - - - - - - HTH_1,LysR_substrate k59_135986_2 472759.Nhal_1807 1.69e-253 729.0 COG4206@1|root,COG4206@2|Bacteria,1QUWU@1224|Proteobacteria,1RN8R@1236|Gammaproteobacteria 1236|Gammaproteobacteria H receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_135986_4 1079986.JH164854_gene615 5.14e-25 107.0 COG4585@1|root,COG4585@2|Bacteria,2GJKG@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_90371_1 1049564.TevJSym_ad01170 3.07e-68 228.0 COG5148@1|root,COG5148@2|Bacteria,1QTZE@1224|Proteobacteria,1RY3H@1236|Gammaproteobacteria,1J5W5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_18714_1 1265505.ATUG01000002_gene1616 4.55e-210 615.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales 28221|Deltaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 k59_51627_2 1232437.KL662042_gene2011 8.48e-61 197.0 COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42Y9C@68525|delta/epsilon subdivisions,2WUJJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_193923_1 344747.PM8797T_29453 2.19e-48 174.0 COG3039@1|root,COG3039@2|Bacteria 2|Bacteria L Transposase - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_168273_3 34506.g602 1.04e-11 67.4 29M9D@1|root,2RUJ1@2759|Eukaryota,38Y58@33154|Opisthokonta,3CESE@33208|Metazoa,3DW5Q@33213|Bilateria,40H8J@6231|Nematoda 34506.g602|- S C-5 cytosine-specific DNA methylase - - - - - - - - - - - - - k59_168273_4 1410626.JHXB01000010_gene2793 3.18e-05 47.8 COG1396@1|root,COG1396@2|Bacteria,1V7XY@1239|Firmicutes,24M2R@186801|Clostridia,27P39@186928|unclassified Lachnospiraceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_181460_1 479434.Sthe_1776 4.07e-12 71.6 COG0577@1|root,COG3127@1|root,COG0577@2|Bacteria,COG3127@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia 189775|Thermomicrobia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_200290_1 706587.Desti_4447 2.5e-111 342.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MQZE@213462|Syntrophobacterales 28221|Deltaproteobacteria T Cache domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 k59_200290_2 97139.C824_05722 6.2e-12 65.5 COG0745@1|root,COG0745@2|Bacteria,1TSCM@1239|Firmicutes,248K7@186801|Clostridia,36FU9@31979|Clostridiaceae 186801|Clostridia KT response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_103208_1 1121943.KB899995_gene833 1.9e-47 162.0 COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,1RZWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_103208_2 1547437.LL06_02250 6.13e-22 91.7 COG4665@1|root,COG4665@2|Bacteria,1R24M@1224|Proteobacteria,2TZH9@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_194366_1 237368.SCABRO_00359 9.73e-90 280.0 COG3961@1|root,COG3961@2|Bacteria,2IY2K@203682|Planctomycetes 203682|Planctomycetes C Belongs to the TPP enzyme family - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_32382_1 744980.TRICHSKD4_1847 9.06e-12 63.9 COG5005@1|root,COG5005@2|Bacteria,1Q6DQ@1224|Proteobacteria,2UIZG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S to Mu-like prophage FluMu protein gp36 (P44230) - - - - - - - - - - - - Phage_tail_S k59_57676_1 335543.Sfum_3456 6.79e-38 130.0 2B84D@1|root,321CH@2|Bacteria,1RGVR@1224|Proteobacteria,42SGF@68525|delta/epsilon subdivisions,2WPEJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 k59_57676_2 1304885.AUEY01000047_gene81 3.01e-24 104.0 COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N,YbbR k59_206959_1 1411123.JQNH01000001_gene83 2.84e-23 109.0 COG3209@1|root,COG3209@2|Bacteria,1R31H@1224|Proteobacteria 1224|Proteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - - k59_200298_2 629265.PMA4326_08980 7.47e-19 87.4 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,1RRWB@1236|Gammaproteobacteria,1Z5DT@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - HAD,UbiA k59_5716_1 1286171.EAL2_c10780 1.57e-164 477.0 28JM7@1|root,2Z9DS@2|Bacteria,1TQQE@1239|Firmicutes,253HP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_5716_3 637390.AFOH01000130_gene1985 2.64e-144 419.0 2AQCG@1|root,31FIP@2|Bacteria,1QD4G@1224|Proteobacteria,1T905@1236|Gammaproteobacteria,2NDQ3@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_5716_5 1298593.TOL_2970 9.36e-75 225.0 28UAR@1|root,30WN8@2|Bacteria,1RFZJ@1224|Proteobacteria,1S57Z@1236|Gammaproteobacteria,1XP6W@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_5716_6 1298593.TOL_2971 2.2e-32 114.0 2C0F8@1|root,336M1@2|Bacteria,1NB64@1224|Proteobacteria,1SFW2@1236|Gammaproteobacteria,1XMUN@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_5717_1 768671.ThimaDRAFT_4175 2.81e-76 250.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_181481_1 62928.azo2041 8.68e-37 132.0 28MWI@1|root,2ZB3T@2|Bacteria,1RAPA@1224|Proteobacteria,2VPKV@28216|Betaproteobacteria 28216|Betaproteobacteria S plasmid encoded RepA protein - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - RepA_C k59_200302_1 1232437.KL662042_gene2036 2.99e-25 99.8 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,42SFZ@68525|delta/epsilon subdivisions,2WPY5@28221|Deltaproteobacteria,2MNXZ@213118|Desulfobacterales 28221|Deltaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_168306_1 283699.D172_1212 2.68e-38 146.0 COG3227@1|root,COG3227@2|Bacteria,1P416@1224|Proteobacteria,1RR7I@1236|Gammaproteobacteria,2Q0GV@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E COG3227 Zinc metalloprotease (elastase) - - 3.4.24.25 ko:K08604 ko05110,ko05111,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002 - - - FTP,PPC,PepSY,Peptidase_M4,Peptidase_M4_C k59_57681_1 1049564.TevJSym_au00010 7.63e-85 279.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1J8QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_168307_1 716928.AJQT01000047_gene2151 8.6e-75 234.0 COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,4B76N@82115|Rhizobiaceae 28211|Alphaproteobacteria G ABC transporter permease MA20_03545 - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_142515_1 335543.Sfum_3204 1.42e-41 141.0 COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,430JJ@68525|delta/epsilon subdivisions,2WVQQ@28221|Deltaproteobacteria,2MRZH@213462|Syntrophobacterales 28221|Deltaproteobacteria S Cyclophilin-like - - - ko:K09143 - - - - ko00000 - - - Cyclophil_like k59_85090_1 1049564.TevJSym_ad01170 1.22e-85 278.0 COG5148@1|root,COG5148@2|Bacteria,1QTZE@1224|Proteobacteria,1RY3H@1236|Gammaproteobacteria,1J5W5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_97953_1 519989.ECTPHS_09373 9.47e-57 210.0 COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,1T1GM@1236|Gammaproteobacteria 1236|Gammaproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_97953_3 425104.Ssed_1285 1.98e-90 302.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2Q95S@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_65639_1 1269813.ATUL01000014_gene1474 6.6e-26 110.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWT2@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_3 k59_7379_1 1049564.TevJSym_aq00730 1.08e-54 179.0 COG4508@1|root,COG4508@2|Bacteria,1RAX1@1224|Proteobacteria,1RYFG@1236|Gammaproteobacteria,1J5W3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S dUTPase dut - - - - - - - - - - - dUTPase_2 k59_7379_2 414684.RC1_2705 2.06e-124 374.0 COG4580@1|root,COG4580@2|Bacteria,1MX77@1224|Proteobacteria,2UGWF@28211|Alphaproteobacteria 28211|Alphaproteobacteria G LamB porin - - - ko:K02024 - - - - ko00000,ko02000 1.B.3.1.1 - - LamB k59_85092_1 2340.JV46_19120 6.02e-114 339.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain dgcB - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_201861_1 1049564.TevJSym_au00250 1.01e-119 345.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1J4TT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_91511_2 289376.THEYE_A1361 5.09e-63 201.0 COG1392@1|root,COG1392@2|Bacteria 2|Bacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_156403_1 644282.Deba_0055 1.01e-11 72.8 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_39681_1 1049564.TevJSym_aj00350 4.79e-62 207.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1J4PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_13717_1 1049564.TevJSym_ar00090 2.06e-229 637.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1J5D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_130531_2 518766.Rmar_0538 0.000941 42.7 COG2041@1|root,COG2041@2|Bacteria,4NK0M@976|Bacteroidetes 976|Bacteroidetes S Oxidoreductase molybdopterin binding domain - - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_162946_1 1390370.O203_15565 9.75e-34 135.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1YE19@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_39683_1 1232410.KI421421_gene3869 2.64e-92 281.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_91516_1 420662.Mpe_A3819 3.1e-68 219.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,1KN3K@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_52673_1 2340.JV46_10870 1.92e-120 370.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_33218_1 768671.ThimaDRAFT_4015 9.87e-184 524.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales 135613|Chromatiales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_7384_1 1049564.TevJSym_ad00540 8.06e-48 157.0 COG0852@1|root,COG0852@2|Bacteria,1RB4M@1224|Proteobacteria,1S3KE@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_7384_2 768671.ThimaDRAFT_1751 1.9e-182 514.0 COG0649@1|root,COG0649@2|Bacteria,1R5JW@1224|Proteobacteria,1RT5B@1236|Gammaproteobacteria,1WXBK@135613|Chromatiales 135613|Chromatiales C belongs to the complex I 49 kDa subunit family - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_46136_1 1298593.TOL_1415 2.11e-36 136.0 28HNB@1|root,2Z7WM@2|Bacteria,1MWQ1@1224|Proteobacteria,1RZ55@1236|Gammaproteobacteria,1XITS@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_46136_2 525897.Dbac_0479 4.27e-46 160.0 COG1246@1|root,COG1246@2|Bacteria,1R0RF@1224|Proteobacteria 1224|Proteobacteria E TIGRFAM C_GCAxxG_C_C family protein - - - - - - - - - - - - C_GCAxxG_C_C k59_46136_3 713586.KB900536_gene2312 3.64e-161 459.0 COG1943@1|root,COG1943@2|Bacteria,1MVUV@1224|Proteobacteria,1RNIV@1236|Gammaproteobacteria,1WZXR@135613|Chromatiales 1236|Gammaproteobacteria L COG1943 Transposase and inactivated derivatives - - - - - - - - - - - - - k59_46136_4 1049564.TevJSym_ao00080 3.36e-186 521.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G sugar kinase adoK - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_195181_1 765912.Thimo_1917 4.47e-172 502.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1WVZE@135613|Chromatiales 135613|Chromatiales G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_39689_1 391009.Tmel_0204 1.58e-08 62.8 COG1032@1|root,COG1032@2|Bacteria,2GCP5@200918|Thermotogae 200918|Thermotogae C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_85102_1 272123.Anacy_0582 2.32e-28 116.0 COG0732@1|root,COG0732@2|Bacteria,1G6EU@1117|Cyanobacteria,1HPPM@1161|Nostocales 1117|Cyanobacteria V PFAM Type I restriction modification DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_85102_2 319224.Sputcn32_0161 7.59e-88 273.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,2Q9J0@267890|Shewanellaceae 1236|Gammaproteobacteria L PFAM N-6 DNA methylase hsdM - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_20184_1 1283284.AZUK01000001_gene1930 7.06e-187 532.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1S3FN@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - HD_5 k59_20184_4 1047013.AQSP01000049_gene2263 9.52e-83 268.0 COG0399@1|root,COG0399@2|Bacteria 2|Bacteria E UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91 k59_20184_5 743299.Acife_1499 6.17e-181 514.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RR5N@1236|Gammaproteobacteria,2NDPF@225057|Acidithiobacillales 225057|Acidithiobacillales S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_91523_1 1121935.AQXX01000096_gene2554 3.6e-105 309.0 28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,1RSHA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_724_2 1049564.TevJSym_ai00140 2.56e-91 270.0 COG0242@1|root,COG0242@2|Bacteria,1QM3A@1224|Proteobacteria,1RZHN@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_724_3 1049564.TevJSym_ai00150 1.2e-78 238.0 COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,1S2A4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_724_4 292415.Tbd_0811 1.87e-28 108.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,1KS0Z@119069|Hydrogenophilales 119069|Hydrogenophilales S Multi-copper polyphenol oxidoreductase laccase - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_182396_2 76114.p2B22 3.92e-55 175.0 2C092@1|root,31AZX@2|Bacteria,1RH67@1224|Proteobacteria,2VTRJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_182396_3 1177179.A11A3_14040 1.19e-84 271.0 COG3843@1|root,COG3843@2|Bacteria,1QUDG@1224|Proteobacteria,1RSQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase k59_149996_1 439235.Dalk_4413 1.78e-11 63.2 COG2919@1|root,COG2919@2|Bacteria,1Q1R7@1224|Proteobacteria,437ED@68525|delta/epsilon subdivisions,2X2KR@28221|Deltaproteobacteria,2MMCS@213118|Desulfobacterales 28221|Deltaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_72176_1 1229780.BN381_250012 4.15e-40 152.0 COG3464@1|root,COG3464@2|Bacteria,2I56J@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - - k59_175810_1 1049564.TevJSym_ac01390 1.71e-79 251.0 COG0760@1|root,COG0760@2|Bacteria,1NQU6@1224|Proteobacteria,1SMIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - - k59_85109_1 335543.Sfum_0614 2.41e-41 144.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - - - - - - - - - - CN_hydrolase k59_188865_3 338969.Rfer_0255 1.08e-27 108.0 COG3303@1|root,COG3303@2|Bacteria,1NX4E@1224|Proteobacteria 1224|Proteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_182399_1 1122599.AUGR01000015_gene2746 6.3e-26 98.6 2ED9V@1|root,33769@2|Bacteria,1N87Z@1224|Proteobacteria,1SR1E@1236|Gammaproteobacteria,1XPJD@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_97967_1 765913.ThidrDRAFT_0584 9.84e-88 261.0 COG1036@1|root,COG1036@2|Bacteria,1RD5I@1224|Proteobacteria,1S59C@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Flavoprotein - - - - - - - - - - - - Flavoprotein k59_97967_2 1207076.ALAT01000161_gene3362 1.05e-61 210.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQMR@1236|Gammaproteobacteria,1Z06N@136846|Pseudomonas stutzeri group 1224|Proteobacteria KQ Transcriptional activator of acetoin glycerol metabolism acoR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,PAS_8,Sigma54_activat k59_130552_1 765913.ThidrDRAFT_3052 1.72e-137 395.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales 135613|Chromatiales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_182401_1 591158.SSMG_04507 7.64e-42 152.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria 201174|Actinobacteria E ABC transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_59211_1 1049564.TevJSym_bc00290 1.62e-55 182.0 28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,1S2DJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_59211_2 1049564.TevJSym_bc00300 1.41e-217 605.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_33229_1 765911.Thivi_1736 4.37e-62 194.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_33229_2 83406.HDN1F_23540 2.24e-72 231.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1J4X9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_20193_1 335543.Sfum_0154 7.83e-285 797.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales 28221|Deltaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_7406_1 1129374.AJE_08220 6.11e-69 224.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,469FZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_188881_1 1121324.CLIT_2c00070 5.22e-66 213.0 COG0477@1|root,COG2814@2|Bacteria,1V0Z5@1239|Firmicutes,24B0J@186801|Clostridia 186801|Clostridia EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_169402_1 368407.Memar_1357 2.9e-92 281.0 COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia 224756|Methanomicrobia O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_20194_1 1134413.ANNK01000127_gene2497 3.19e-06 55.5 COG0673@1|root,COG0673@2|Bacteria,1TQSS@1239|Firmicutes,4HCIG@91061|Bacilli,1ZBUF@1386|Bacillus 91061|Bacilli S Oxidoreductase yulF GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114,GO:0102497 - ko:K22230 ko00562,ko01120,map00562,map01120 - R09954 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA k59_91546_1 1167006.UWK_03514 6.37e-77 248.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2MJ6H@213118|Desulfobacterales 28221|Deltaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_740_1 1335757.SPICUR_03670 5.66e-46 155.0 COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1SNG7@1236|Gammaproteobacteria,1X27W@135613|Chromatiales 135613|Chromatiales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_7407_1 1049564.TevJSym_aj00410 4.43e-128 385.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1J51W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1032 Fe-S oxidoreductase ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_130562_2 439235.Dalk_2534 9.3e-124 366.0 COG0436@1|root,COG0436@2|Bacteria,1QW10@1224|Proteobacteria,42MQA@68525|delta/epsilon subdivisions,2WJDK@28221|Deltaproteobacteria,2MJ7D@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM aminotransferase class I and II bamJ - - - - - - - - - - - Aminotran_1_2 k59_13727_1 998674.ATTE01000001_gene2963 6.29e-92 280.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - APH k59_13727_2 204773.HEAR0033 2.62e-29 110.0 COG0216@1|root,COG0216@2|Bacteria,1R348@1224|Proteobacteria,2WIF9@28216|Betaproteobacteria,4796S@75682|Oxalobacteraceae 28216|Betaproteobacteria J RF-1 domain yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_13727_3 1121035.AUCH01000005_gene35 7.14e-75 229.0 COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria,2KWB4@206389|Rhodocyclales 206389|Rhodocyclales S YaeQ family - - - - - - - - - - - - YaeQ k59_98589_1 1163617.SCD_n01287 6.21e-82 251.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_3 moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_53365_1 1479237.JMLY01000001_gene2559 4.38e-70 219.0 2DMFW@1|root,32R8M@2|Bacteria,1RGXW@1224|Proteobacteria,1SH7G@1236|Gammaproteobacteria,4690P@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - VPEP k59_157123_2 1123401.JHYQ01000014_gene801 6.04e-55 177.0 COG0589@1|root,COG0589@2|Bacteria,1N9QR@1224|Proteobacteria,1S5P4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_8052_1 1049564.TevJSym_ad00770 2.33e-21 86.3 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1J78B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_8052_2 1049564.TevJSym_ad00760 1.46e-133 387.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1J4S7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_8052_3 1049564.TevJSym_ad00750 2.61e-156 444.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1J9IK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_8052_4 566466.NOR53_15 8.59e-34 141.0 COG0624@1|root,COG0823@1|root,COG0624@2|Bacteria,COG0823@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1J4HK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_8052_5 1523503.JPMY01000003_gene4209 5.63e-55 182.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the GST superfamily yfcG - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_8052_6 953739.SVEN_0928 2.31e-116 356.0 COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria 201174|Actinobacteria C Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_85821_2 720554.Clocl_2673 8.33e-57 200.0 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,3WGT5@541000|Ruminococcaceae 186801|Clostridia L Mu transposase, C-terminal - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_144408_2 1049564.TevJSym_at00220 2.85e-153 440.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1J4W3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_144408_3 555778.Hneap_2346 1.61e-15 72.8 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales 135613|Chromatiales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_21098_2 1249627.D779_2335 1.25e-19 87.4 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales 135613|Chromatiales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_59975_1 96561.Dole_0088 1.59e-25 104.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2MI7D@213118|Desulfobacterales 28221|Deltaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_59975_2 96561.Dole_0089 3.65e-49 168.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2MHN5@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3198 AA_kinase,PUA k59_92434_1 765911.Thivi_3688 2.1e-25 96.7 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYH0@135613|Chromatiales 135613|Chromatiales K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_92434_2 1049564.TevJSym_bb00300 6.53e-102 302.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1S0ZZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Response regulator receiver - - - - - - - - - - - - PAS,PAS_9,Response_reg k59_46946_1 933262.AXAM01000013_gene1318 4.12e-94 295.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_40631_1 948106.AWZT01000038_gene1180 1.8e-29 120.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2VI1A@28216|Betaproteobacteria,1K12V@119060|Burkholderiaceae 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_47227_2 1192034.CAP_1503 1.91e-24 102.0 COG3794@1|root,COG3794@2|Bacteria,1RHQU@1224|Proteobacteria,434YV@68525|delta/epsilon subdivisions,2WZ9S@28221|Deltaproteobacteria,2Z1NI@29|Myxococcales 28221|Deltaproteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_157392_1 983545.Glaag_2332 1.49e-98 323.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D1@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_189912_1 1283300.ATXB01000001_gene1797 2.48e-60 198.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XDTP@135618|Methylococcales 135618|Methylococcales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_189912_2 1286106.MPL1_08768 1.91e-31 123.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,4605Q@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_8348_1 1051632.TPY_3150 2.23e-108 325.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia 186801|Clostridia L PFAM transposase, mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1599_1 395493.BegalDRAFT_3113 9.31e-34 122.0 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,1SAXA@1236|Gammaproteobacteria,462P4@72273|Thiotrichales 72273|Thiotrichales K Ferric uptake regulator family - - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_1599_2 550540.Fbal_1759 2.41e-24 94.4 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_125233_1 177437.HRM2_43800 1.07e-18 85.5 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,2MMU6@213118|Desulfobacterales 28221|Deltaproteobacteria S Pfam:TPM - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase k59_118753_1 1382306.JNIM01000001_gene2574 6.03e-38 143.0 COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi 200795|Chloroflexi S CBS domain containing protein - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_170656_2 458817.Shal_0526 3.31e-19 89.0 2DN9P@1|root,32WA7@2|Bacteria,1N472@1224|Proteobacteria,1SHE9@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_86100_1 335543.Sfum_2602 5.7e-73 236.0 COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2MQV1@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase,QRPTase_C k59_40972_1 1173020.Cha6605_4234 7.48e-46 157.0 COG3967@1|root,COG3967@2|Bacteria,1G8SW@1117|Cyanobacteria 1117|Cyanobacteria M Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K08151,ko:K14189 - M00668 - - ko00000,ko00002,ko01000,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - adh_short k59_131734_1 857087.Metme_1124 3.98e-177 587.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEIX@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_131734_2 203122.Sde_3266 1.8e-70 228.0 2E0EH@1|root,32W10@2|Bacteria,1NV08@1224|Proteobacteria,1SNIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_53594_1 519989.ECTPHS_14156 1.67e-67 207.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_176960_1 382464.ABSI01000002_gene4375 1.55e-87 266.0 COG2878@1|root,COG2878@2|Bacteria 2|Bacteria C electron transfer activity rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4,Fer4_7 k59_157399_1 1049564.TevJSym_ao00460 4.11e-56 196.0 COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1RYQ0@1236|Gammaproteobacteria,1J6S3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3426) - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_163942_1 1249627.D779_4081 5.66e-46 153.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1WX4R@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding k59_47240_1 1049564.TevJSym_ab01370 4.97e-109 320.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria,1J5UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain chvI GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K02483,ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_34333_1 243233.MCA0692 1.47e-66 226.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,1XDV6@135618|Methylococcales 135618|Methylococcales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,UvrD_C_2 k59_8363_2 237368.SCABRO_03382 2.58e-26 107.0 COG0677@1|root,COG0677@2|Bacteria,2IXVX@203682|Planctomycetes 203682|Planctomycetes M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_92813_1 768671.ThimaDRAFT_4303 5.69e-65 211.0 COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria,1WWDM@135613|Chromatiales 135613|Chromatiales CP PFAM NADH Ubiquinone plastoquinone - - - ko:K12141 - - - - ko00000,ko01000 - - - Proton_antipo_M k59_92813_2 765911.Thivi_2909 1.11e-186 537.0 COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria,1WWJR@135613|Chromatiales 135613|Chromatiales C NADH dehydrogenase - - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_170676_1 1266925.JHVX01000012_gene1688 5.69e-26 97.4 COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales 28216|Betaproteobacteria S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_125259_1 768671.ThimaDRAFT_2942 4.49e-29 116.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1WXU8@135613|Chromatiales 135613|Chromatiales C oxidoreductase, alpha subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N,Transketolase_C k59_125259_2 1085623.GNIT_0707 0.000201 42.7 COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF - - - - - - - - - - - OmpA k59_21782_2 1121405.dsmv_2856 1.01e-73 249.0 COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_119056_3 1049564.TevJSym_ap00120 2.05e-71 219.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1J6NS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_119056_4 288000.BBta_2603 1.38e-33 123.0 COG3794@1|root,COG3794@2|Bacteria,1QXEE@1224|Proteobacteria,2TX92@28211|Alphaproteobacteria,3K6TE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_119056_5 1485545.JQLW01000005_gene975 5.11e-38 133.0 COG0789@1|root,COG0789@2|Bacteria,1RJD4@1224|Proteobacteria 1224|Proteobacteria K Transcriptional - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_119056_7 1049564.TevJSym_ap00050 3.15e-39 146.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_119056_8 529709.PYCH_09060 5.82e-11 59.7 arCOG03911@1|root,arCOG03911@2157|Archaea,2Y7IE@28890|Euryarchaeota,244G7@183968|Thermococci 183968|Thermococci S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_196214_1 859657.RPSI07_3165 6.22e-11 73.2 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,1KBKG@119060|Burkholderiaceae 28216|Betaproteobacteria Q Haemolysin-type calcium binding protein related domain - - - - - - - - - - - - HCBP_related,HemolysinCabind,LysM k59_196214_2 1049564.TevJSym_bj00220 2.62e-106 358.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1JBUC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind k59_196214_4 398525.KB900701_gene1905 5.69e-15 74.3 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TTX9@28211|Alphaproteobacteria,3JRHM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M TIGRFAM type I secretion membrane fusion protein, HlyD family hlyD - - ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_177259_1 1049564.TevJSym_ai00520 2.42e-42 157.0 COG2199@1|root,COG4223@1|root,COG2199@2|Bacteria,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_125554_1 640081.Dsui_3422 1.92e-11 63.5 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,2VT8G@28216|Betaproteobacteria,2KWR8@206389|Rhodocyclales 206389|Rhodocyclales P Hemerythrin-like metal-binding protein - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_60481_1 472759.Nhal_0915 5.37e-75 239.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WWA9@135613|Chromatiales 135613|Chromatiales C PFAM FAD dependent oxidoreductase - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_80097_8 1121935.AQXX01000138_gene3194 6.7e-58 209.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1XIYN@135619|Oceanospirillales 135619|Oceanospirillales T Diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_99071_1 1049564.TevJSym_bm00110 8.44e-70 216.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1J609@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain letA - - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_144944_1 349124.Hhal_1674 1.27e-14 73.2 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales 135613|Chromatiales E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_144944_2 59374.Fisuc_1286 7.63e-12 64.3 COG0499@1|root,COG0499@2|Bacteria 2|Bacteria H adenosylhomocysteinase activity ahcY GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_8653_1 304371.MCP_1923 2.57e-58 191.0 COG2801@1|root,arCOG10339@2157|Archaea 2157|Archaea L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_66805_1 292415.Tbd_2289 7.23e-53 174.0 COG3709@1|root,COG3709@2|Bacteria,1RGXZ@1224|Proteobacteria,2VSGN@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) phnN - 2.7.4.23 ko:K05774 ko00030,map00030 - R06836 RC00002 ko00000,ko00001,ko01000 - - - AAA_18,Guanylate_kin k59_66805_2 1304883.KI912532_gene809 2.36e-19 85.9 COG3454@1|root,COG3454@2|Bacteria,1MV7H@1224|Proteobacteria,2VMPU@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphonate metabolism protein PhnM phnM - 3.6.1.63 ko:K06162 ko00440,map00440 - R10186 RC00002 ko00000,ko00001,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_112361_2 246197.MXAN_0593 2.28e-23 103.0 COG1819@1|root,COG1819@2|Bacteria,1QWRW@1224|Proteobacteria 1224|Proteobacteria CG Belongs to the UDP-glycosyltransferase family crtX - 2.4.1.276 ko:K14596 ko00906,map00906 - R07574 RC00005,RC01992 ko00000,ko00001,ko01000,ko01003 - GT1 - Glyco_tran_28_C,UDPGT k59_112361_3 1150626.PHAMO_340075 1.2e-153 444.0 COG0502@1|root,COG0502@2|Bacteria,1R8GT@1224|Proteobacteria,2U89T@28211|Alphaproteobacteria,2JV93@204441|Rhodospirillales 204441|Rhodospirillales C Elongator protein 3, MiaB family, Radical SAM - - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_112361_4 1150469.RSPPHO_00585 2.51e-208 586.0 COG0486@1|root,COG0486@2|Bacteria,1PM94@1224|Proteobacteria,2U0C7@28211|Alphaproteobacteria,2JV9N@204441|Rhodospirillales 204441|Rhodospirillales S Ferrous iron transport protein B - - - - - - - - - - - - MMR_HSR1 k59_112361_5 1150469.RSPPHO_00584 4.29e-06 48.5 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2TVZD@28211|Alphaproteobacteria,2JYUB@204441|Rhodospirillales 204441|Rhodospirillales E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_1862_1 1307761.L21SP2_2067 7.37e-90 278.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,Mu-transpos_C,rve k59_137972_2 1109445.AGSX01000084_gene3235 1.71e-32 132.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1Z2CY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_28076_1 485913.Krac_2547 1.29e-75 241.0 COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi 2|Bacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Glutaredoxin,Pyr_redox_2 k59_14685_2 83406.HDN1F_37360 8.19e-37 126.0 COG5302@1|root,COG5302@2|Bacteria,1NIFA@1224|Proteobacteria,1SD2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid ccdA - - ko:K19164 - - - - ko00000,ko02048 - - - CcdA k59_14685_3 83406.HDN1F_37350 6.39e-45 147.0 2DNNV@1|root,32YCB@2|Bacteria,1N7IN@1224|Proteobacteria,1S9V9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM CcdB protein ccdB - - ko:K19163 - - - - ko00000,ko02048 - - - CcdB k59_14685_4 882.DVU_1703 0.0 1459.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,42M86@68525|delta/epsilon subdivisions,2WIT1@28221|Deltaproteobacteria,2M8F1@213115|Desulfovibrionales 28221|Deltaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_14685_5 290633.GOX2566 1.84e-60 197.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U86R@28211|Alphaproteobacteria,2JY3N@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_196222_1 546273.VEIDISOL_00910 3.76e-14 71.2 COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,4H48E@909932|Negativicutes 909932|Negativicutes H cob(I)yrinic acid a,c-diamide adenosyltransferase cobO - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_125565_1 933262.AXAM01000002_gene545 6.27e-65 210.0 COG1639@1|root,COG1639@2|Bacteria,1RBFE@1224|Proteobacteria,42QRK@68525|delta/epsilon subdivisions,2WMYG@28221|Deltaproteobacteria,2MJHI@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD,zinc_ribbon_4 k59_41288_1 1232410.KI421415_gene3068 1.94e-49 179.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,43U59@69541|Desulfuromonadales 28221|Deltaproteobacteria M Organic solvent tolerance protein lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iAF987.Gmet_2474 OstA,OstA_2,OstA_C k59_184003_1 1123368.AUIS01000006_gene527 7.33e-57 190.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1TB6C@1236|Gammaproteobacteria,2NDKC@225057|Acidithiobacillales 225057|Acidithiobacillales S Phage portal protein, lambda family - - - - - - - - - - - - Phage_portal_2 k59_144953_1 227377.CBU_1290 1.1e-121 366.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1JCN6@118969|Legionellales 118969|Legionellales O Heat shock 70 kDa protein dnaK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_119080_1 589924.Ferp_0391 3.96e-35 131.0 arCOG00937@1|root,arCOG00937@2157|Archaea,2Y2E6@28890|Euryarchaeota 28890|Euryarchaeota C 4Fe-4S single cluster domain - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM k59_119080_2 1163408.UU9_09087 4.79e-09 56.6 COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,1S5VD@1236|Gammaproteobacteria,1XBWX@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 k59_8664_1 443144.GM21_3331 2.84e-153 452.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_41291_1 512565.AMIS_58920 1.07e-32 132.0 COG3210@1|root,COG4842@1|root,COG3210@2|Bacteria,COG4842@2|Bacteria 2|Bacteria S protein secretion by the type VII secretion system mshQ - - ko:K12287 - - - - ko00000,ko02044 - - - Laminin_G_3 k59_86416_1 1209072.ALBT01000067_gene102 2.75e-52 179.0 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,1RS5T@1236|Gammaproteobacteria,1FFYF@10|Cellvibrio 1236|Gammaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_177272_1 1121447.JONL01000010_gene2377 8.33e-34 135.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R6F@68525|delta/epsilon subdivisions,2WN2B@28221|Deltaproteobacteria,2M95Y@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HD_5,Response_reg k59_177272_2 330214.NIDE2816 6.28e-50 174.0 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,3J0NC@40117|Nitrospirae 40117|Nitrospirae T HDOD domain - - - - - - - - - - - - HDOD k59_184009_1 555779.Dthio_PD0351 2.84e-41 153.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MAFI@213115|Desulfovibrionales 28221|Deltaproteobacteria S pfam abc1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_80105_1 443143.GM18_2767 2e-93 282.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,43V8D@69541|Desulfuromonadales 28221|Deltaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_80105_2 879212.DespoDRAFT_02827 3.13e-190 546.0 COG4584@1|root,COG4584@2|Bacteria,1MW5J@1224|Proteobacteria,42X93@68525|delta/epsilon subdivisions,2WSXR@28221|Deltaproteobacteria,2MQ06@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM Integrase core domain - - - - - - - - - - - - rve k59_85004_1 1049564.TevJSym_au00310 4.26e-141 428.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1J4CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O peptidyl-prolyl isomerase ppiD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_59110_1 330214.NIDE4145 2.76e-139 409.0 COG1004@1|root,COG1004@2|Bacteria,3J0EJ@40117|Nitrospirae 40117|Nitrospirae C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_59110_2 795359.TOPB45_1189 8.84e-31 117.0 2CA4A@1|root,32RQK@2|Bacteria,2GH7R@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Domain of unknown function (DUF4416) - - - - - - - - - - - - DUF4416 k59_52555_1 1121405.dsmv_2856 1.46e-212 610.0 COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_195097_1 485915.Dret_2002 1.08e-189 538.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_201783_1 1408428.JNJP01000069_gene1272 7.27e-27 113.0 COG0827@1|root,COG0827@2|Bacteria,1N9G8@1224|Proteobacteria,42YEM@68525|delta/epsilon subdivisions,2WTY5@28221|Deltaproteobacteria,2ME31@213115|Desulfovibrionales 28221|Deltaproteobacteria L Domain of unknown function (DUF4942) - - - - - - - - - - - - DUF4942 k59_104401_1 314278.NB231_04320 3.83e-28 124.0 2EH77@1|root,33AZ1@2|Bacteria,1NMNZ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_136887_1 452637.Oter_4527 1.24e-44 166.0 COG0553@1|root,COG0553@2|Bacteria,46U72@74201|Verrucomicrobia,3K7EW@414999|Opitutae 414999|Opitutae L RNA polymerase recycling family C-terminal - - - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_110939_1 706587.Desti_5501 1.26e-138 409.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_20112_1 933262.AXAM01000010_gene1394 2.73e-108 327.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales 28221|Deltaproteobacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_123923_1 301.JNHE01000008_gene3736 1.61e-66 207.0 COG0563@1|root,COG0563@2|Bacteria,1RCIS@1224|Proteobacteria,1S692@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0563 Adenylate kinase and related kinases - - - - - - - - - - - - - k59_91423_2 1318628.MARLIPOL_13019 5.45e-36 130.0 COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigV - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_26732_1 335543.Sfum_0065 6.46e-135 397.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MQ63@213462|Syntrophobacterales 28221|Deltaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_26732_2 1121440.AUMA01000018_gene1997 9.46e-12 63.5 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2M92Q@213115|Desulfovibrionales 28221|Deltaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_188742_1 1286093.C266_03848 1.45e-10 61.2 COG1846@1|root,COG1846@2|Bacteria,1N150@1224|Proteobacteria,2VVF3@28216|Betaproteobacteria,1K6JN@119060|Burkholderiaceae 28216|Betaproteobacteria K Regulatory protein MarR hcaR - - - - - - - - - - - MarR,MarR_2 k59_188742_2 1114970.PSF113_2579 1.26e-56 196.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1SKJU@1236|Gammaproteobacteria,1YSB6@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S MMPL family - - - - - - - - - - - - MMPL k59_46083_2 177437.HRM2_25960 3.26e-46 157.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,42QZX@68525|delta/epsilon subdivisions,2WN5T@28221|Deltaproteobacteria,2MJPX@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_85012_1 706587.Desti_4338 3.6e-40 142.0 COG2502@1|root,COG2502@2|Bacteria,1MVWF@1224|Proteobacteria 1224|Proteobacteria E aspartate--ammonia ligase asnA GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299 AsnA,tRNA-synt_2 k59_85012_2 553177.CAPSP0001_2490 1.42e-05 46.2 COG2005@1|root,COG2005@2|Bacteria,4NUSR@976|Bacteroidetes,1I43Z@117743|Flavobacteriia,1ES1G@1016|Capnocytophaga 976|Bacteroidetes S Transcriptional regulator, LysR family - - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1 k59_91424_1 1480694.DC28_15440 3.38e-112 339.0 COG3328@1|root,COG3328@2|Bacteria,2J57X@203691|Spirochaetes 203691|Spirochaetes L PFAM Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_175712_3 41431.PCC8801_3988 1.38e-142 421.0 COG3387@1|root,COG3387@2|Bacteria,1G04Y@1117|Cyanobacteria,3KGUW@43988|Cyanothece 1117|Cyanobacteria G Glycosyl hydrolases family 15 - - - ko:K07190 ko04020,ko04910,ko04922,map04020,map04910,map04922 - - - ko00000,ko00001 - - - Glyco_hydro_15 k59_175712_4 1121405.dsmv_2272 2.31e-10 66.2 2AQ61@1|root,31FBI@2|Bacteria,1P7BX@1224|Proteobacteria,43326@68525|delta/epsilon subdivisions,2WYGH@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_175712_5 313606.M23134_01329 1.03e-17 85.1 COG2003@1|root,COG2003@2|Bacteria,4NFBF@976|Bacteroidetes,47KTY@768503|Cytophagia 976|Bacteroidetes E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_169283_1 1487953.JMKF01000019_gene2282 5.99e-11 66.2 COG1462@1|root,COG1462@2|Bacteria,1G2XT@1117|Cyanobacteria,1HARS@1150|Oscillatoriales 1117|Cyanobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG k59_72074_1 637389.Acaty_c1155 5.66e-14 72.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,2NCCE@225057|Acidithiobacillales 225057|Acidithiobacillales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_72074_2 269799.Gmet_0865 4.34e-38 135.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,42S4S@68525|delta/epsilon subdivisions,2WNIV@28221|Deltaproteobacteria,43S1H@69541|Desulfuromonadales 28221|Deltaproteobacteria F cytidylate kinase activity cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_85018_1 1219035.NT2_27_00020 3.85e-10 66.6 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2K503@204457|Sphingomonadales 204457|Sphingomonadales L PFAM Transposase IS116 IS110 IS902 family, Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_169284_1 517418.Ctha_0918 3.19e-91 275.0 COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi 1090|Chlorobi P TIGRFAM phosphate ABC transporter, inner membrane subunit PstC - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_117455_3 1049564.TevJSym_ab00910 1.17e-29 124.0 COG2304@1|root,COG2304@2|Bacteria,1MVJ2@1224|Proteobacteria,1RMUF@1236|Gammaproteobacteria,1J5FC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S von Willebrand factor type A domain - - - - - - - - - - - - VWA,VWA_3 k59_59121_2 323850.Shew_2749 2.56e-97 290.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,2Q9J6@267890|Shewanellaceae 1236|Gammaproteobacteria K Two component transcriptional regulator, winged helix family phoB GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_59121_4 1049564.TevJSym_ak00590 0.0 956.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_59121_5 1049564.TevJSym_ak00580 1.06e-60 194.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1J6IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG3087 Cell division protein ftsN - - ko:K03591 - - - - ko00000,ko03036 - - - SPOR k59_59121_6 1049564.TevJSym_ak00570 1.33e-26 99.8 2EGR8@1|root,33AHD@2|Bacteria,1N6Z8@1224|Proteobacteria,1SDY4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S FeoC like transcriptional regulator - - - - - - - - - - - - FeoC k59_59121_7 2340.JV46_09860 1.52e-97 309.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1J5MJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_78697_1 215803.DB30_5083 6.85e-13 70.5 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z45@68525|delta/epsilon subdivisions,2WTWB@28221|Deltaproteobacteria,2YW9J@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HAMP,HATPase_c,HisKA,PAS_4 k59_137080_1 1122599.AUGR01000022_gene1659 5.07e-50 167.0 COG1737@1|root,COG1737@2|Bacteria,1N3YS@1224|Proteobacteria,1S32Z@1236|Gammaproteobacteria,1XJSB@135619|Oceanospirillales 135619|Oceanospirillales K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS k59_91684_2 765913.ThidrDRAFT_0589 2.93e-81 247.0 COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,1RR15@1236|Gammaproteobacteria,1X1GH@135613|Chromatiales 135613|Chromatiales U PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_202026_1 203122.Sde_2045 4.05e-131 433.0 COG3210@1|root,COG3210@2|Bacteria,1QQD4@1224|Proteobacteria,1RZ1D@1236|Gammaproteobacteria,46BII@72275|Alteromonadaceae 1236|Gammaproteobacteria U Mandelate Racemase Muconate Lactonizing - - - - - - - - - - - - - k59_7509_1 1122599.AUGR01000016_gene2834 1.25e-85 267.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHAV@135619|Oceanospirillales 135619|Oceanospirillales Q PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_91686_1 1499684.CCNP01000020_gene2506 7.25e-88 270.0 COG1145@1|root,COG1145@2|Bacteria,1TQG5@1239|Firmicutes,248IV@186801|Clostridia,36FZ5@31979|Clostridiaceae 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_6,Fer4_7 k59_98078_1 631362.Thi970DRAFT_00774 5.95e-62 194.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1WXZ5@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_98078_2 1049564.TevJSym_ch00040 1.91e-06 50.1 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1J4VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_98078_3 1054213.HMPREF9946_00014 2.32e-60 191.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,2JSWF@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the UPF0260 family - - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_130721_1 933262.AXAM01000031_gene3022 7.24e-67 215.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MI5I@213118|Desulfobacterales 28221|Deltaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_188989_1 234267.Acid_6259 7.77e-59 199.0 COG1321@1|root,COG1321@2|Bacteria 2|Bacteria K iron dependent repressor nagC - - ko:K02003,ko:K02565,ko:K15545 - M00258 - - ko00000,ko00002,ko02000,ko03000 3.A.1 - - HTH_IclR,MarR,ROK k59_169561_1 706587.Desti_0760 4.76e-112 337.0 COG0025@1|root,COG0025@2|Bacteria,1REWR@1224|Proteobacteria,437JE@68525|delta/epsilon subdivisions,2X2TE@28221|Deltaproteobacteria,2MQZ0@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_46270_1 1121396.KB893075_gene665 1.91e-138 407.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_46270_2 56780.SYN_01908 3.17e-41 137.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MS29@213462|Syntrophobacterales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_175957_2 1165841.SULAR_06623 6.08e-19 84.7 COG2703@1|root,COG2703@2|Bacteria 2|Bacteria P oxygen carrier activity - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_175957_3 626887.J057_19160 1.62e-84 259.0 COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,1S1Z5@1236|Gammaproteobacteria,466W9@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1024 Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_175957_4 1248232.BANQ01000074_gene1615 1.16e-55 179.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,1S6S0@1236|Gammaproteobacteria,1XX0H@135623|Vibrionales 135623|Vibrionales S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_175957_5 396588.Tgr7_2053 6.02e-32 112.0 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Fe-S assembly protein IscX iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_175957_6 305900.GV64_13045 4.98e-68 206.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1XK66@135619|Oceanospirillales 135619|Oceanospirillales C Ferredoxin - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_175957_7 1049564.TevJSym_au00160 2.28e-122 368.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1J4XK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_85214_1 768671.ThimaDRAFT_0933 2.96e-14 72.4 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1WX3R@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_117735_1 1163408.UU9_16971 9.13e-21 86.7 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1X36J@135614|Xanthomonadales 135614|Xanthomonadales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_117735_2 1049564.TevJSym_bu00110 2.17e-46 152.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1J6N9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_52851_1 313628.LNTAR_10286 1.82e-67 216.0 COG1349@1|root,COG1349@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - 3.6.4.12 ko:K02444,ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - AlbA_2,DUF1670,DeoRC,HATPase_c_4,HTH_DeoR k59_33366_2 1193181.BN10_1590020 6.47e-31 121.0 COG1619@1|root,COG1619@2|Bacteria,2HPR8@201174|Actinobacteria 201174|Actinobacteria V Peptidase U61, LD-carboxypeptidase A - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_124167_1 1005048.CFU_1957 2.61e-73 229.0 COG2197@1|root,COG2197@2|Bacteria,1R4TP@1224|Proteobacteria,2VQJX@28216|Betaproteobacteria,4777P@75682|Oxalobacteraceae 28216|Betaproteobacteria K Autoinducer binding domain - - - ko:K07782 ko02020,ko02024,ko02026,map02020,map02024,map02026 - - - ko00000,ko00001,ko03000 - - - Autoind_bind,GerE k59_72332_1 1379281.AVAG01000033_gene484 1.06e-31 112.0 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MCGN@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the UPF0109 family - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_72332_2 497321.C664_13539 1.98e-06 51.6 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria,2KWFJ@206389|Rhodocyclales 206389|Rhodocyclales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_188997_1 1117647.M5M_05690 6.14e-44 150.0 COG3637@1|root,COG3637@2|Bacteria,1PES3@1224|Proteobacteria,1RWRV@1236|Gammaproteobacteria,1J77C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M OmpA-like transmembrane domain - - - - - - - - - - - - OMP_b-brl k59_864_1 933262.AXAM01000008_gene1933 5.63e-61 192.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,43ADJ@68525|delta/epsilon subdivisions,2WMPS@28221|Deltaproteobacteria,2MJJ7@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_0920 SIS_2 k59_26986_2 1049564.TevJSym_af00780 1.13e-111 347.0 2BVW8@1|root,33KZU@2|Bacteria,1NIUH@1224|Proteobacteria,1SI5Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - PilZ k59_46281_1 434131.NRI_0927 6.41e-47 169.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,47F4A@766|Rickettsiales 766|Rickettsiales S hmm tigr01630 - - - - - - - - - - - - Terminase_6C k59_175969_1 335543.Sfum_0342 3.77e-60 199.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria,2MRE2@213462|Syntrophobacterales 28221|Deltaproteobacteria KT PFAM Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_143616_1 1049564.TevJSym_al00240 9.09e-51 168.0 2EN7Y@1|root,33FVR@2|Bacteria,1NHR8@1224|Proteobacteria,1SH6M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_172553_1 96561.Dole_0333 1.75e-50 174.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales 28221|Deltaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_128215_1 671143.DAMO_3055 2.28e-22 101.0 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2NQQA@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain lolE-2 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_95886_1 768706.Desor_0428 1.15e-47 184.0 COG0823@1|root,COG2247@1|root,COG0823@2|Bacteria,COG2247@2|Bacteria 2|Bacteria M cell wall organization - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - CW_binding_2,CarboxypepD_reg,Flg_new,NHL,PD40,Peptidase_S8,TIG,VCBS k59_95886_2 1565129.JSFF01000002_gene3520 1.39e-136 409.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,1RNY4@1236|Gammaproteobacteria,2Q9D8@267890|Shewanellaceae 1236|Gammaproteobacteria P PhoD-like phosphatase, N-terminal domain phoD - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_16692_1 743721.Psesu_1175 3.87e-42 170.0 2DNH7@1|root,32XH1@2|Bacteria,1RHPW@1224|Proteobacteria,1T56U@1236|Gammaproteobacteria,1X3WB@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_192176_1 314275.MADE_1002965 4.15e-23 103.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,465G4@72275|Alteromonadaceae 1236|Gammaproteobacteria G Beta-N-acetylhexosaminidase ybbD - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C k59_108101_1 1049564.TevJSym_ab00150 2.32e-56 197.0 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1JB0I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_3712_1 644282.Deba_1016 6.53e-95 284.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42N2W@68525|delta/epsilon subdivisions,2WJRB@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_134077_3 1333856.L686_16095 1.17e-08 56.2 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Z27R@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_205036_1 1121396.KB893084_gene407 2.82e-102 306.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria,2MKDA@213118|Desulfobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_140091_1 1049564.TevJSym_ah00180 1.03e-71 238.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1J4IX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_49661_1 396588.Tgr7_0534 7.07e-05 43.9 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RQMD@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_49661_3 402626.Rpic_1954 1.15e-41 150.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VK64@28216|Betaproteobacteria,1K0U3@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the HpcH HpaI aldolase family hpaI - 4.1.2.52 ko:K02510 ko00350,ko01120,map00350,map01120 - R01645,R01647 RC00307,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_49661_4 667015.Bacsa_1842 1.46e-21 86.7 28VGQ@1|root,2ZHJ7@2|Bacteria 2|Bacteria - - - - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - - k59_49661_5 1499967.BAYZ01000017_gene6232 3.52e-34 121.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_49661_6 1499967.BAYZ01000017_gene6234 1.82e-127 382.0 COG0028@1|root,COG0028@2|Bacteria,2NNMW@2323|unclassified Bacteria 2|Bacteria EH thiamine pyrophosphate protein TPP binding domain protein ilvB1 GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_88512_1 485915.Dret_0478 2.71e-71 225.0 COG0765@1|root,COG0765@2|Bacteria,1R4RU@1224|Proteobacteria,42PW7@68525|delta/epsilon subdivisions,2WK9J@28221|Deltaproteobacteria,2M8W2@213115|Desulfovibrionales 28221|Deltaproteobacteria P polar amino acid ABC transporter, inner membrane subunit - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_10980_1 589865.DaAHT2_1902 1.41e-56 199.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_153230_1 631362.Thi970DRAFT_03637 4.41e-107 315.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1WWUU@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_153230_2 754477.Q7C_1107 5.22e-43 147.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,460RQ@72273|Thiotrichales 72273|Thiotrichales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_121659_2 1049564.TevJSym_am00130 8.96e-126 375.0 COG2271@1|root,COG2271@2|Bacteria,1QUF4@1224|Proteobacteria,1RPSF@1236|Gammaproteobacteria,1JC0D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Acetyl-coenzyme A transporter 1 ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_114365_1 439235.Dalk_3415 2.27e-82 272.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MMWB@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_179477_1 187272.Mlg_2127 1.05e-60 207.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_30151_2 553385.JEMF01000025_gene79 6.12e-07 53.9 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,1XI4B@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF k59_128232_1 321332.CYB_2009 2.5e-14 77.8 COG2362@1|root,COG2362@2|Bacteria 2|Bacteria E D-aminopeptidase - - - ko:K16203 - - - - ko00000,ko01000,ko01002 3.A.1.5.2 - - Peptidase_M55 k59_49671_1 153948.NAL212_3119 8.4e-53 174.0 COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,2WFCR@28216|Betaproteobacteria 1224|Proteobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_75189_1 1117647.M5M_08940 9.96e-244 688.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,1J5H3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_114367_1 933262.AXAM01000081_gene2258 5.88e-27 102.0 COG1925@1|root,COG1925@2|Bacteria,1QN8R@1224|Proteobacteria,43EVZ@68525|delta/epsilon subdivisions,2X2HJ@28221|Deltaproteobacteria,2MM7I@213118|Desulfobacterales 28221|Deltaproteobacteria G TIGRFAM phosphocarrier, HPr family - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_69400_1 247490.KSU1_D0048 1.69e-15 79.3 COG4191@1|root,COG4191@2|Bacteria,2IZZK@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_69400_2 589865.DaAHT2_0439 0.000709 42.0 COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,2MJD2@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_10981_1 1122197.ATWI01000008_gene2766 5.57e-244 692.0 COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria 1224|Proteobacteria O PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_95907_1 1049564.TevJSym_ai01020 3.33e-153 451.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1J8HK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S M61 glycyl aminopeptidase - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_121665_1 335543.Sfum_2567 4.84e-150 430.0 COG2069@1|root,COG2069@2|Bacteria,1QS8G@1224|Proteobacteria,437H2@68525|delta/epsilon subdivisions,2WKVX@28221|Deltaproteobacteria,2MQ9D@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase delta subunit - - 2.1.1.245 ko:K00194 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD k59_16714_1 331678.Cphamn1_2389 4.44e-07 52.4 COG3449@1|root,COG3449@2|Bacteria,1FEUM@1090|Chlorobi 1090|Chlorobi L PFAM SOUL heme-binding protein - - - - - - - - - - - - SOUL k59_108114_1 156889.Mmc1_2506 2.26e-106 317.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C small subunit - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_108114_2 156889.Mmc1_2505 1.99e-179 506.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4_11,Fer4_4 k59_108114_3 156889.Mmc1_2504 1.31e-94 286.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,2U4H3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C PFAM Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_55623_1 439235.Dalk_3994 3.3e-154 455.0 COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,42U8I@68525|delta/epsilon subdivisions,2WQCY@28221|Deltaproteobacteria,2MNWM@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_82233_1 247490.KSU1_B0383 1.81e-22 107.0 2E4WW@1|root,32ZQY@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_88792_4 644801.Psest_4110 4.37e-133 404.0 COG2131@1|root,COG2131@2|Bacteria,1QDAH@1224|Proteobacteria,1RRDW@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Deoxycytidylate deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_88792_6 1156844.KB891842_gene7193 0.0 929.0 COG3387@1|root,COG3387@2|Bacteria,2IEP5@201174|Actinobacteria 201174|Actinobacteria G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - - k59_88792_9 392500.Swoo_2371 1.52e-08 60.5 COG1752@1|root,COG1752@2|Bacteria,1N5JZ@1224|Proteobacteria 1224|Proteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - - k59_114701_1 983545.Glaag_3662 4.11e-49 170.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,46AM5@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_63231_1 1219045.BV98_003429 8.79e-72 234.0 COG2207@1|root,COG2207@2|Bacteria,1MXT9@1224|Proteobacteria,2U0UP@28211|Alphaproteobacteria,2KCUE@204457|Sphingomonadales 204457|Sphingomonadales K AraC-binding-like domain - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_140473_1 234267.Acid_4746 1.66e-96 295.0 COG5659@1|root,COG5659@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - DDE_5 k59_108492_2 1333507.AUTQ01000111_gene1206 2.26e-06 50.8 2EICS@1|root,33C43@2|Bacteria,1NIAI@1224|Proteobacteria,1SGPY@1236|Gammaproteobacteria,2Q2VQ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_108492_3 1380387.JADM01000004_gene3045 1.06e-92 278.0 COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,1RPM8@1236|Gammaproteobacteria,1XJ97@135619|Oceanospirillales 135619|Oceanospirillales U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_108492_4 1502851.FG93_01365 1.71e-10 68.2 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria,3JW2E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Hpt domain - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_166406_1 1121405.dsmv_0234 3.14e-54 189.0 COG1055@1|root,COG1055@2|Bacteria,1N68M@1224|Proteobacteria,42PD9@68525|delta/epsilon subdivisions,2WKRV@28221|Deltaproteobacteria,2MMQP@213118|Desulfobacterales 28221|Deltaproteobacteria P Putative Na+/H+ antiporter - - - - - - - - - - - - Na_H_antiport_3 k59_205357_1 1499967.BAYZ01000154_gene1502 1.36e-51 179.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_82561_2 1317118.ATO8_00265 4.89e-06 47.0 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2U80W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_55888_1 1123279.ATUS01000001_gene1469 3.62e-70 237.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J4C5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,Globin,HAMP,MCPsignal,PAS_3,PAS_8,PAS_9 k59_108494_1 1120948.KB903244_gene3054 7.05e-24 106.0 COG1260@1|root,COG1260@2|Bacteria,2GJVN@201174|Actinobacteria,4DY1V@85010|Pseudonocardiales 201174|Actinobacteria I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 k59_11263_2 1123360.thalar_01601 1.25e-05 49.7 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_147247_1 765913.ThidrDRAFT_0560 6.47e-120 358.0 COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1X07F@135613|Chromatiales 135613|Chromatiales C TIGRFAM Formylmethanofuran dehydrogenase, subunit A - - 1.2.7.12 ko:K00200 ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 k59_37349_1 1049564.TevJSym_bq00070 6.52e-72 235.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_82564_1 589865.DaAHT2_0059 2.56e-105 314.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2MJCB@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_55892_1 1232410.KI421425_gene1543 1.14e-47 164.0 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_55892_2 1232410.KI421425_gene1546 1.26e-43 147.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales 28221|Deltaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_134400_1 472759.Nhal_0597 1.06e-81 265.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_63237_1 218493.SBG_1846 4.84e-19 95.5 COG3064@1|root,COG3209@1|root,COG3210@1|root,COG3064@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3ZMVI@590|Salmonella 1236|Gammaproteobacteria M Domain of unknown function (DUF4150) - - - - - - - - - - - - DUF4150,PAAR_motif,RHS,RHS_repeat,Tox-HNH-EHHH k59_179792_1 335543.Sfum_0364 4.99e-42 155.0 COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2MRP4@213462|Syntrophobacterales 28221|Deltaproteobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_75518_1 1167006.UWK_00560 2.13e-136 427.0 COG3005@1|root,COG3005@2|Bacteria,1NFFE@1224|Proteobacteria,430BS@68525|delta/epsilon subdivisions,2WVRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 k59_96232_1 456442.Mboo_2091 3.58e-64 214.0 COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia 224756|Methanomicrobia C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_4003_2 768671.ThimaDRAFT_0204 1.53e-149 442.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_75519_1 335543.Sfum_0020 2.86e-105 328.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_128572_1 933262.AXAM01000021_gene448 2.94e-58 203.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2MIG6@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_140489_2 1049564.TevJSym_at00430 1.86e-157 453.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1J4X9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_149687_3 251221.35214256 1.08e-106 316.0 COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria 1117|Cyanobacteria S TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - - - - - - - - - - - HAD_2 k59_78697_2 439235.Dalk_2419 2.42e-47 166.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria,2MIGZ@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_642_1 1122197.ATWI01000009_gene1505 0.000122 50.1 2DR3T@1|root,33A1M@2|Bacteria,1QZB5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - VPEP k59_642_2 1049564.TevJSym_av00410 3.77e-126 365.0 COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,1RP6P@1236|Gammaproteobacteria,1J6NW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the glycosyltransferase 26 family - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB k59_642_3 1049564.TevJSym_av00420 1.13e-81 253.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1J66T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Bacterial sugar transferase rfbP GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0016740,GO:0016772,GO:0016780,GO:0043170,GO:0044238,GO:0071704 2.7.8.6 ko:K00996,ko:K16707 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 k59_136896_1 1049564.TevJSym_ba00170 8.39e-91 271.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1J513@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_136896_2 768671.ThimaDRAFT_2156 1.71e-61 193.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_33150_1 1125863.JAFN01000001_gene236 9.15e-48 166.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_26744_1 1049564.TevJSym_af00790 1.95e-42 152.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Virulence factor BrkB rbn GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_175724_1 335543.Sfum_3197 3.13e-119 360.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MQ7P@213462|Syntrophobacterales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_65593_1 1150469.RSPPHO_01750 2.62e-14 72.8 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2JPT2@204441|Rhodospirillales 204441|Rhodospirillales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_156344_1 1123228.AUIH01000010_gene3976 1.94e-10 67.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,1XH6I@135619|Oceanospirillales 135619|Oceanospirillales M Rhs family - - - - - - - - - - - - RHS,RHS_repeat,Tox-HNH-EHHH k59_149932_1 439235.Dalk_1916 7.14e-53 167.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MK4M@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_149932_2 933262.AXAM01000052_gene1988 2.25e-91 277.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_52591_1 1049564.TevJSym_aw00450 1.56e-27 119.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J50D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT COG0643 Chemotaxis protein histidine kinase and related kinases cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_143339_1 1121935.AQXX01000055_gene2911 4.4e-33 119.0 COG0419@1|root,COG0419@2|Bacteria,1R040@1224|Proteobacteria 1224|Proteobacteria L Plasmid replication region DNA-binding N-term - - - - - - - - - - - - KfrA_N k59_143339_2 1121935.AQXX01000055_gene2913 2.17e-171 480.0 2CCC4@1|root,2Z7X6@2|Bacteria,1QNH6@1224|Proteobacteria,1S0UX@1236|Gammaproteobacteria,1XN97@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_143339_3 1121935.AQXX01000055_gene2914 1.79e-177 498.0 COG3598@1|root,COG3598@2|Bacteria,1R4V4@1224|Proteobacteria,1RSMQ@1236|Gammaproteobacteria,1XP6K@135619|Oceanospirillales 135619|Oceanospirillales L AAA domain - - - - - - - - - - - - AAA_25 k59_143339_4 754477.Q7C_1418 3.29e-13 65.1 290Q8@1|root,2ZNCG@2|Bacteria,1P9W2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_143339_5 1121935.AQXX01000055_gene2915 8.32e-115 332.0 COG5018@1|root,COG5018@2|Bacteria,1RE77@1224|Proteobacteria,1S8NC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Exonuclease - - - - - - - - - - - - RNase_T k59_162884_5 1123401.JHYQ01000017_gene2509 5.62e-46 159.0 292F7@1|root,2ZPZF@2|Bacteria,1RGFI@1224|Proteobacteria,1S48P@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_162885_1 335543.Sfum_2345 2.7e-74 238.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MRAR@213462|Syntrophobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_162885_2 404589.Anae109_3714 1.47e-15 70.5 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_65595_2 1535422.ND16A_1114 9.75e-37 139.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RQ9W@1236|Gammaproteobacteria 1236|Gammaproteobacteria L to Escherichia coli transposase for insertion sequence element IS21 IstA SW ISTA_ECOLI (P15025) (390 aa) fasta scores E() 3e-27, 33.1 id in 329 aa. Identical to the previously sequenced Yersinia pestis,Yersinia pseudotuberculosis and Escherichia coli pesticin plasmid insertion sequence transposase Y1055 TR P74993 (EMBL U59875) (340 aa) fasta scores E() 0, 100.0 id in 340 aa - - - - - - - - - - - - HTH_23,rve k59_78721_1 748280.NH8B_0143 2.22e-64 207.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KU4J@206351|Neisseriales 206351|Neisseriales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_78721_2 1049564.TevJSym_aa00820 1.8e-71 224.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1J5P0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858 AAA_26 k59_657_2 269799.Gmet_0011 1.05e-27 111.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43C40@68525|delta/epsilon subdivisions,2X7EG@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase fgrK - - - - - - - - - - - HATPase_c,HisKA k59_117471_1 1123518.ARWI01000001_gene583 2.09e-86 266.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,461S9@72273|Thiotrichales 72273|Thiotrichales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_59137_1 1132855.KB913035_gene1911 3.47e-108 329.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,2KKTT@206350|Nitrosomonadales 206350|Nitrosomonadales J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_78723_1 1265505.ATUG01000001_gene4508 3.02e-150 436.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFQ@28221|Deltaproteobacteria,2MIXP@213118|Desulfobacterales 28221|Deltaproteobacteria T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_39634_2 398580.Dshi_2345 0.000168 45.4 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2U0JP@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator nreC - - ko:K02479,ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_46103_1 439235.Dalk_1330 1.18e-60 199.0 COG3464@1|root,COG3464@2|Bacteria,1PFY7@1224|Proteobacteria,4377W@68525|delta/epsilon subdivisions,2X29U@28221|Deltaproteobacteria,2MP93@213118|Desulfobacterales 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_110975_1 1121405.dsmv_2460 2.05e-89 279.0 COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1R05R@1224|Proteobacteria,42QEV@68525|delta/epsilon subdivisions,2WMBG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_143345_2 1134474.O59_003578 3.06e-23 94.0 COG0226@1|root,COG0226@2|Bacteria,1N7RX@1224|Proteobacteria,1TC1T@1236|Gammaproteobacteria,1FI9W@10|Cellvibrio 1236|Gammaproteobacteria P ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - - k59_13687_2 398512.JQKC01000052_gene2672 1.32e-84 262.0 2C8MZ@1|root,2ZA7T@2|Bacteria,1UFFD@1239|Firmicutes,24F4E@186801|Clostridia,3WN3M@541000|Ruminococcaceae 186801|Clostridia S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_20150_1 1179778.PMM47T1_28583 4.8e-89 283.0 COG0358@1|root,COG0358@2|Bacteria,1MWSP@1224|Proteobacteria,1RYXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA primase - - - - - - - - - - - - Toprim_2,Toprim_N,zf-CHC2 k59_52597_1 1121405.dsmv_2870 4.64e-43 157.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MHXP@213118|Desulfobacterales 28221|Deltaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_143348_1 1380387.JADM01000001_gene53 8e-29 111.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1XJJR@135619|Oceanospirillales 135619|Oceanospirillales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_72107_1 1123401.JHYQ01000016_gene2978 1.18e-91 282.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Iron-sulfur cluster binding protein lutB - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_195123_2 768671.ThimaDRAFT_1411 1.13e-148 434.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales 135613|Chromatiales CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_195123_3 2340.JV46_12200 2.42e-63 206.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_117485_1 243233.MCA1973 8.87e-26 102.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1XFC3@135618|Methylococcales 135618|Methylococcales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_123974_1 1211777.BN77_p11647 1.09e-31 129.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 k59_676_1 62928.azo2540 2.6e-120 354.0 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2VMCM@28216|Betaproteobacteria 28216|Betaproteobacteria I Dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - DUF1932,NAD_binding_2 k59_676_2 395495.Lcho_3635 5.07e-53 174.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VIDM@28216|Betaproteobacteria,1KJZX@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Amidohydrolase - - 3.1.1.57 ko:K10221 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R04277 RC03110 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_20158_2 1232410.KI421426_gene1360 2.98e-28 113.0 COG0845@1|root,COG0845@2|Bacteria,1R443@1224|Proteobacteria,43A2V@68525|delta/epsilon subdivisions,2X238@28221|Deltaproteobacteria,43VF8@69541|Desulfuromonadales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - - - - - - - - - - HlyD_D23 k59_39836_1 1304872.JAGC01000009_gene892 1.81e-83 272.0 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2M83U@213115|Desulfovibrionales 28221|Deltaproteobacteria KT SMART protein phosphatase 2C domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,SpoIIE k59_111177_1 1122201.AUAZ01000023_gene2989 1.06e-157 492.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,1RY2M@1236|Gammaproteobacteria,46772@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3 k59_111177_3 1157632.AQWQ01000002_gene4685 5.5e-85 261.0 COG0599@1|root,COG0599@2|Bacteria,2GITB@201174|Actinobacteria 201174|Actinobacteria I decarboxylase - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_111177_4 123899.JPQP01000023_gene2933 7.47e-37 140.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2W1BN@28216|Betaproteobacteria,3T9A0@506|Alcaligenaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_26948_2 439235.Dalk_1495 1.39e-79 247.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2MI27@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_20302_1 883080.HMPREF9697_00863 1.58e-45 159.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3JTXU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component MA20_30170 - - - - - - - - - - - DctM k59_20302_2 1089552.KI911559_gene2411 1.39e-18 82.4 COG3090@1|root,COG3090@2|Bacteria,1MVKS@1224|Proteobacteria,2U08K@28211|Alphaproteobacteria,2JSXA@204441|Rhodospirillales 204441|Rhodospirillales G COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - - - - - - - - - - DctQ k59_195233_1 331869.BAL199_11576 1.01e-161 463.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,4BP5C@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_195233_2 765912.Thimo_1799 9.1e-61 196.0 COG2230@1|root,COG2230@2|Bacteria,1QUR4@1224|Proteobacteria,1RP3C@1236|Gammaproteobacteria,1WX7D@135613|Chromatiales 135613|Chromatiales M Methyltransferase - - 2.1.1.157 ko:K18897 ko00260,map00260 - R10061 RC00003,RC03040 ko00000,ko00001,ko01000 - - - Methyltransf_11 k59_98062_1 1232437.KL662025_gene932 1.74e-116 345.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2MHP8@213118|Desulfobacterales 28221|Deltaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_85190_2 1145276.T479_08180 9.91e-46 151.0 COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,4HH0A@91061|Bacilli,3J05Z@400634|Lysinibacillus 91061|Bacilli K HxlR-like helix-turn-helix ydeP3 - - - - - - - - - - - HxlR k59_85190_3 857087.Metme_1306 1.79e-90 270.0 COG0778@1|root,COG0778@2|Bacteria,1RBZQ@1224|Proteobacteria,1S328@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitroreductase drgA - - - - - - - - - - - Nitroreductase k59_130684_1 1121405.dsmv_2856 8.49e-121 363.0 COG3039@1|root,COG3039@2|Bacteria,1PKUP@1224|Proteobacteria,43ECD@68525|delta/epsilon subdivisions,2X0BQ@28221|Deltaproteobacteria,2MP4F@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - - k59_78931_1 1049564.TevJSym_ak00690 4.93e-157 491.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1J61D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_188954_1 70734.Q8W737_9CAUD 0.00022 53.1 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QHYN@10662|Myoviridae 10662|Myoviridae S amidase activity - - - - - - - - - - - - - k59_152618_1 1167006.UWK_00817 2.11e-74 250.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MMWB@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_113776_1 396588.Tgr7_0539 1.23e-52 172.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1X07Q@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_113776_2 1397527.Q670_09735 2.87e-10 59.3 COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria 1236|Gammaproteobacteria U COG0848 Biopolymer transport protein - - - - - - - - - - - - ExbD k59_185568_1 706587.Desti_0760 1.5e-121 363.0 COG0025@1|root,COG0025@2|Bacteria,1REWR@1224|Proteobacteria,437JE@68525|delta/epsilon subdivisions,2X2TE@28221|Deltaproteobacteria,2MQZ0@213462|Syntrophobacterales 28221|Deltaproteobacteria P PFAM sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_107437_1 880073.Calab_0353 7.47e-08 58.9 COG3328@1|root,COG3328@2|Bacteria,2NQXQ@2323|unclassified Bacteria 2|Bacteria L COGs COG3328 Transposase and inactivated derivatives tnp - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_68652_2 272568.GDI3454 9.17e-13 69.3 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_146390_1 83406.HDN1F_35310 2.7e-61 196.0 2D5ZD@1|root,32TK4@2|Bacteria,1NZJR@1224|Proteobacteria,1SPSJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_146390_2 83406.HDN1F_17870 2.46e-33 123.0 COG2944@1|root,COG5606@1|root,COG2944@2|Bacteria,COG5606@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_37,Peptidase_S24 k59_146390_3 1121935.AQXX01000127_gene1209 2.43e-62 196.0 COG0847@1|root,COG0847@2|Bacteria,1P2A7@1224|Proteobacteria,1SSAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - - - - - - - - - - - - k59_29502_1 335543.Sfum_0434 2.44e-62 202.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2MRWI@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_3149_2 880072.Desac_1854 8.23e-27 107.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria 2|Bacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small k59_204507_2 983920.Y88_2969 4.15e-81 250.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,2K0YQ@204457|Sphingomonadales 204457|Sphingomonadales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_87865_1 1112217.PPL19_00945 1.09e-41 155.0 COG2197@1|root,COG2197@2|Bacteria,1NPE8@1224|Proteobacteria 1224|Proteobacteria K luxR family - - - - - - - - - - - - GerE k59_87865_2 1218084.BBJK01000086_gene5807 1.97e-53 181.0 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,2VMFV@28216|Betaproteobacteria,1K7GZ@119060|Burkholderiaceae 28216|Betaproteobacteria P Rieske [2Fe-2S] domain - - 1.14.15.23 ko:K22325 - - - - ko00000,ko01000 - - - Rieske k59_36299_1 55601.VANGNB10_cII1009c 1.15e-21 99.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XV3Y@135623|Vibrionales 135623|Vibrionales NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PAS_8,PAS_9 k59_36299_2 395493.BegalDRAFT_2479 3.96e-55 182.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,461ZM@72273|Thiotrichales 72273|Thiotrichales NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_95139_1 644282.Deba_1491 7.89e-115 340.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_197680_1 339670.Bamb_6614 4.69e-112 341.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K2G6@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA topoisomerase - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_197680_2 232721.Ajs_4318 1.1e-61 195.0 COG4959@1|root,COG4959@2|Bacteria,1RBHE@1224|Proteobacteria,2VQ0M@28216|Betaproteobacteria,4AINH@80864|Comamonadaceae 28216|Betaproteobacteria OU Conjugation peptidase TraF. Serine peptidase. MEROPS family S26C - - - - - - - - - - - - Peptidase_S26 k59_107444_1 909663.KI867149_gene3364 2.36e-78 248.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2MQT1@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_16049_1 1049564.TevJSym_au00490 3.15e-242 677.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1J4XM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_152629_2 1538295.JY96_10685 3.65e-23 102.0 COG0332@1|root,COG0332@2|Bacteria,1R0TR@1224|Proteobacteria,2WHW0@28216|Betaproteobacteria 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_23243_1 68170.KL590482_gene696 4.4e-27 110.0 COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4E0F2@85010|Pseudonocardiales 201174|Actinobacteria S Reductase C-terminal - - 1.18.1.3 ko:K00529 ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220 M00545 R02000,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2,Reductase_C k59_23243_2 1123288.SOV_5c00860 4.58e-47 185.0 COG1629@1|root,COG4771@2|Bacteria,1VUVU@1239|Firmicutes,4H97K@909932|Negativicutes 909932|Negativicutes P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_197684_1 933262.AXAM01000049_gene3268 1.16e-12 69.3 COG0589@1|root,COG0589@2|Bacteria,1N2H4@1224|Proteobacteria,42UE7@68525|delta/epsilon subdivisions,2WQV7@28221|Deltaproteobacteria,2MKEV@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_191668_1 911239.CF149_04849 1.09e-13 68.9 COG1028@1|root,COG1028@2|Bacteria,1RA3U@1224|Proteobacteria,1S2N2@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_191668_3 1304885.AUEY01000012_gene1777 4.43e-84 252.0 COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria,2MKH6@213118|Desulfobacterales 28221|Deltaproteobacteria Q FtsJ-like methyltransferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_107445_2 1283300.ATXB01000001_gene1739 1.18e-120 347.0 COG4185@1|root,COG4185@2|Bacteria,1RFDC@1224|Proteobacteria,1SG1X@1236|Gammaproteobacteria,1XGUF@135618|Methylococcales 135618|Methylococcales S protein conserved in bacteria - - - - - - - - - - - - - k59_113792_1 335543.Sfum_0192 4.71e-122 376.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MQ5P@213462|Syntrophobacterales 28221|Deltaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_152632_2 1121405.dsmv_3223 7.16e-32 115.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2WQ3I@28221|Deltaproteobacteria,2MKN7@213118|Desulfobacterales 28221|Deltaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_139453_1 1049564.TevJSym_aa01930 4.68e-139 431.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_185586_1 4081.Solyc00g025500.1.1 6.2e-20 95.9 2EU4C@1|root,2SWC0@2759|Eukaryota,3827Z@33090|Viridiplantae,3GS0W@35493|Streptophyta 35493|Streptophyta S FCD - - - - - - - - - - - - FCD,GntR k59_81669_1 1242864.D187_007111 1.96e-54 179.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,2YVHT@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1885 PdxJ k59_152635_2 96561.Dole_2880 2.9e-62 195.0 COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MK4I@213118|Desulfobacterales 28221|Deltaproteobacteria C Putative Fe-S cluster - - - - - - - - - - - - FeS k59_10281_1 1049564.TevJSym_aw00350 1.3e-154 452.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1J5N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_120858_1 672.VV93_v1c05190 3.36e-12 70.5 COG1226@1|root,COG1226@2|Bacteria,1RBAK@1224|Proteobacteria,1S5SS@1236|Gammaproteobacteria,1XSZ1@135623|Vibrionales 135623|Vibrionales P COG1226 Kef-type K transport systems VV0578 - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_74534_1 1121403.AUCV01000018_gene3211 3.43e-102 315.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales 28221|Deltaproteobacteria S pfam abc-1 - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_178908_1 1121405.dsmv_1511 3.07e-64 206.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_36309_1 765912.Thimo_2085 1.65e-57 185.0 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1WW6W@135613|Chromatiales 135613|Chromatiales E subfamily IA, variant 3 - - 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD,HAD_2,Hydrolase k59_23258_1 1358423.N180_09035 2.22e-05 48.1 COG0607@1|root,COG3118@1|root,COG0607@2|Bacteria,COG3118@2|Bacteria,4NUPH@976|Bacteroidetes,1IXPM@117747|Sphingobacteriia 976|Bacteroidetes OP Rhodanese Homology Domain glpE - - - - - - - - - - - Rhodanese,Thioredoxin k59_133526_1 1121935.AQXX01000085_gene5323 2.67e-114 337.0 COG1199@1|root,COG1199@2|Bacteria,1MWW0@1224|Proteobacteria,1RRFA@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL HELICc2 - - - - - - - - - - - - DEAD,Helicase_C_2,ResIII k59_127564_1 1169143.KB911040_gene2876 0.0 1477.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1JZNE@119060|Burkholderiaceae 28216|Betaproteobacteria C Formate dehydrogenase alpha subunit fdsA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_81673_1 1297742.A176_02203 1.19e-95 286.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,42QKQ@68525|delta/epsilon subdivisions,2WUIA@28221|Deltaproteobacteria,2YV7F@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the MtfA family - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_62282_1 1395571.TMS3_0121280 5.17e-71 218.0 COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,1S42M@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate cobU GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165 CobU k59_62282_2 1286106.MPL1_02373 7.09e-30 118.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,1RP8G@1236|Gammaproteobacteria,461WS@72273|Thiotrichales 72273|Thiotrichales H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_191674_1 765911.Thivi_0811 5.05e-47 155.0 2E4CH@1|root,32Z7Y@2|Bacteria,1NBRN@1224|Proteobacteria,1SCB9@1236|Gammaproteobacteria,1WYFJ@135613|Chromatiales 135613|Chromatiales S PFAM Type IV pilus assembly PilZ - - - - - - - - - - - - PilZ k59_68876_7 1049564.TevJSym_ar00380 1.39e-12 66.6 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria,1JAK0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5,Pyr_redox_3 k59_107637_1 357804.Ping_1169 2.3e-16 78.2 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,2QH56@267894|Psychromonadaceae 1236|Gammaproteobacteria J Histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_43638_1 396588.Tgr7_0199 3.91e-99 314.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_95384_1 351746.Pput_2189 8.48e-12 70.1 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RQ6B@1236|Gammaproteobacteria,1YVBW@136845|Pseudomonas putida group 1236|Gammaproteobacteria MU RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_95384_2 1424334.W822_06510 1.43e-08 55.1 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3T1PF@506|Alcaligenaceae 28216|Betaproteobacteria U efflux pump - - - ko:K18902,ko:K19585 - M00698,M00767 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.47 - - ACR_tran k59_88033_1 1049564.TevJSym_am00460 5.19e-259 734.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1J4Y8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_16269_1 756499.Desde_0470 4.18e-19 91.3 COG4191@1|root,COG4191@2|Bacteria,1TQKW@1239|Firmicutes,24D67@186801|Clostridia,266RI@186807|Peptococcaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,dCache_1 k59_121110_1 472759.Nhal_3536 6.71e-67 225.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_197872_1 1049564.TevJSym_ae00370 9.58e-177 505.0 2E9CV@1|root,333KG@2|Bacteria,1NT11@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_49263_1 1121405.dsmv_2795 3.38e-59 197.0 COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42P53@68525|delta/epsilon subdivisions,2WJ2U@28221|Deltaproteobacteria,2MIZU@213118|Desulfobacterales 28221|Deltaproteobacteria P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_74723_1 765913.ThidrDRAFT_4377 2.83e-31 112.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,1SCRY@1236|Gammaproteobacteria,1WZEI@135613|Chromatiales 135613|Chromatiales C Cytochrome C551 - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_74723_2 1117647.M5M_18315 1.36e-11 65.1 COG5498@1|root,COG5498@2|Bacteria,1R4DU@1224|Proteobacteria,1RR8D@1236|Gammaproteobacteria,1J894@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM Glycosyl hydrolase family 81 - - - - - - - - - - - - CBM_6,DUF5011,Glyco_hydro_81 k59_43640_2 398767.Glov_3615 8.62e-42 155.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - TIG,Transglut_core k59_23466_3 1229205.BUPH_01430 1.36e-17 80.1 COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,2VWGX@28216|Betaproteobacteria,1K8N0@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_185813_2 1123518.ARWI01000001_gene1638 8.15e-25 98.2 2DQ3J@1|root,334KB@2|Bacteria,1NFUT@1224|Proteobacteria,1SH2X@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_81844_1 572477.Alvin_1073 9.38e-48 173.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_197873_1 251229.Chro_4347 1.72e-67 233.0 COG2770@1|root,COG3322@1|root,COG3852@1|root,COG5001@1|root,COG2770@2|Bacteria,COG3322@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,3VHU5@52604|Pleurocapsales 1117|Cyanobacteria T Diguanylate cyclase (GGDEF domain) - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_133684_1 686340.Metal_0369 3.03e-61 200.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1XE5W@135618|Methylococcales 135618|Methylococcales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_133684_2 2340.JV46_15560 6.5e-67 213.0 COG0204@1|root,COG0204@2|Bacteria,1PDUQ@1224|Proteobacteria,1S51R@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_113944_1 1049564.TevJSym_at00030 4.96e-58 189.0 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_113944_2 1112274.KI911560_gene1493 1.12e-67 211.0 2DUG8@1|root,33QHS@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_113944_4 886293.Sinac_1119 3.81e-168 486.0 COG1262@1|root,COG1262@2|Bacteria,2IXRC@203682|Planctomycetes 203682|Planctomycetes S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_165708_1 1121439.dsat_1659 6.9e-60 201.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42ME4@68525|delta/epsilon subdivisions,2WJA5@28221|Deltaproteobacteria,2MA0T@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_201209_1 933262.AXAM01000014_gene285 2.66e-115 344.0 COG0237@1|root,COG2043@1|root,COG0237@2|Bacteria,COG2043@2|Bacteria,1RCXT@1224|Proteobacteria,42RI5@68525|delta/epsilon subdivisions,2WPDF@28221|Deltaproteobacteria,2MK2V@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_123418_1 1206731.BAGB01000145_gene4198 4.4e-67 214.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2I1D3@201174|Actinobacteria,4G7XC@85025|Nocardiaceae 201174|Actinobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_33 k59_155823_1 686340.Metal_2816 7.07e-92 276.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1XDWZ@135618|Methylococcales 135618|Methylococcales U PFAM MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_155823_2 1026882.MAMP_00018 1.27e-32 118.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,46135@72273|Thiotrichales 72273|Thiotrichales U Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_91036_3 1049564.TevJSym_ac00430 4.16e-111 331.0 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,1J58F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombination rdgC - - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_155827_1 1123236.KB899378_gene1637 6.99e-10 60.1 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,464VH@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_155827_2 1049564.TevJSym_aa00370 2.54e-75 249.0 COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,1RPID@1236|Gammaproteobacteria,1J5G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C k59_58595_1 1049564.TevJSym_bj00130 7.78e-222 638.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1J5A6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_32651_1 648757.Rvan_0347 2.42e-40 150.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,3N627@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_32651_2 472759.Nhal_3737 3.32e-41 135.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1WZ35@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_32651_3 387093.SUN_2181 1.58e-06 55.8 COG0810@1|root,COG0810@2|Bacteria,1NFMG@1224|Proteobacteria,42UAW@68525|delta/epsilon subdivisions,2YQER@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_32651_4 2340.JV46_08360 1.6e-37 131.0 COG0848@1|root,COG0848@2|Bacteria,1PQKY@1224|Proteobacteria,1SG1V@1236|Gammaproteobacteria 1236|Gammaproteobacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_162332_1 765912.Thimo_1580 7.09e-100 315.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_149326_2 926569.ANT_26970 3.21e-06 52.0 COG2010@1|root,COG2864@1|root,COG2010@2|Bacteria,COG2864@2|Bacteria 2|Bacteria C formate dehydrogenase - - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,PSCyt1 k59_71554_1 635013.TherJR_1773 1.45e-21 94.0 COG0382@1|root,COG0382@2|Bacteria,1TQU5@1239|Firmicutes,2486B@186801|Clostridia,25ZZE@186807|Peptococcaceae 186801|Clostridia H PFAM UbiA prenyltransferase - - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_84490_1 224911.27350644 1.19e-77 248.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria,3JQY8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III MA20_45030 - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_6738_1 713586.KB900536_gene1507 6.66e-97 290.0 COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,1WWK9@135613|Chromatiales 135613|Chromatiales C NADH dehydrogenase - - - - - - - - - - - - NADHdh k59_6738_2 765911.Thivi_2911 3.58e-105 310.0 COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,1RRYF@1236|Gammaproteobacteria,1WXDQ@135613|Chromatiales 135613|Chromatiales C hydrogenase 4 membrane - - - ko:K12140 - - - - ko00000,ko01000 - - - - k59_290_1 349521.HCH_06595 3.04e-14 68.6 COG3789@1|root,COG3789@2|Bacteria,1RDFN@1224|Proteobacteria,1S565@1236|Gammaproteobacteria,1XPU7@135619|Oceanospirillales 135619|Oceanospirillales S Uncharacterized protein conserved in bacteria (DUF2170) - - - ko:K09980 - - - - ko00000 - - - DUF2170 k59_290_2 349521.HCH_06594 1.87e-22 90.1 2EA1H@1|root,3346T@2|Bacteria,1NBA3@1224|Proteobacteria,1SFKG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_58606_2 1201288.M900_2631 1.06e-08 58.9 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2MSTA@213481|Bdellovibrionales,2WN0Z@28221|Deltaproteobacteria 213481|Bdellovibrionales G PFAM glycoside hydrolase, family 3 domain protein - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C k59_116925_1 1167006.UWK_02660 4.8e-32 129.0 COG2199@1|root,COG4191@1|root,COG2199@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43D9D@68525|delta/epsilon subdivisions,2X8GQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T TIGRFAM PAS domain S-box - - - - - - - - - - - - GGDEF,PAS_9 k59_58609_1 1283299.AUKG01000001_gene3420 8.82e-74 245.0 COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CQYD@84995|Rubrobacteria 84995|Rubrobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE - - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_162341_1 1232437.KL662020_gene705 1.03e-55 187.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_181734_1 335543.Sfum_2418 1.42e-24 103.0 COG0308@1|root,COG0308@2|Bacteria,1NJK3@1224|Proteobacteria,42Y4Q@68525|delta/epsilon subdivisions,2WTET@28221|Deltaproteobacteria 28221|Deltaproteobacteria E aminopeptidase N - - - - - - - - - - - - Peptidase_MA_2 k59_65056_1 234267.Acid_0127 3.92e-36 135.0 COG1102@1|root,COG1102@2|Bacteria 2|Bacteria F Psort location Cytoplasmic, score - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Cytidylate_kin2,GAF_2,Pribosyltran k59_71562_1 933262.AXAM01000008_gene1947 1.21e-94 287.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2MIV4@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_194633_1 96561.Dole_2842 6.16e-38 139.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MI3C@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_103930_1 335543.Sfum_2852 7.53e-61 197.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2MRRD@213462|Syntrophobacterales 28221|Deltaproteobacteria S Multi-copper polyphenol oxidoreductase laccase - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_26195_1 1049564.TevJSym_at00260 4.15e-284 786.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_26195_2 1049564.TevJSym_at00270 1.76e-126 379.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG4942 Membrane-bound metallopeptidase envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - Peptidase_M23 k59_26195_3 1049564.TevJSym_at00280 7.2e-204 577.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J4IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_26195_4 1049564.TevJSym_at00290 3.01e-82 255.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1J6T5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_26195_5 768671.ThimaDRAFT_2563 5.22e-71 219.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales 135613|Chromatiales S TIGRFAM DJ-1 family protein - - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_26195_6 1049564.TevJSym_at00310 1.12e-300 838.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RYF4@1236|Gammaproteobacteria,1J8MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_2 k59_26195_7 1415630.U771_09380 2.58e-83 263.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) wbpL - - ko:K13007 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_26195_8 204773.HEAR1149 8.15e-97 294.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2VJHC@28216|Betaproteobacteria,476G6@75682|Oxalobacteraceae 28216|Betaproteobacteria M Male sterility protein wbiG - 1.1.1.219,5.1.3.2 ko:K00091,ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_26195_9 1207075.PputUW4_01377 1.19e-209 586.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1RPNC@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues wecB - 3.2.1.183,5.1.3.14 ko:K01791,ko:K08068 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_26195_10 399739.Pmen_1872 1.02e-202 565.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1YDA8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Polysaccharide biosynthesis protein fnlA - 5.1.3.2 ko:K17716 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00362 R00291 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Polysacc_syn_2C,Polysacc_synt_2 k59_26195_11 1094715.CM001373_gene394 1.78e-123 361.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNZ@1236|Gammaproteobacteria,1JDW5@118969|Legionellales 118969|Legionellales M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_26195_12 1221522.B723_08375 5.42e-29 116.0 COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,1RS9J@1236|Gammaproteobacteria,1YT41@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Glycosyl transferase 4-like domain wcaI - - ko:K03208 - - - - ko00000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_58611_1 404589.Anae109_0303 9.91e-39 144.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,42QKZ@68525|delta/epsilon subdivisions,2WJ74@28221|Deltaproteobacteria,2YU8X@29|Myxococcales 28221|Deltaproteobacteria H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_123445_1 888059.HMPREF9071_1575 1.28e-18 79.0 COG0776@1|root,COG0776@2|Bacteria,4NSK6@976|Bacteroidetes,1I43K@117743|Flavobacteriia,1ESC1@1016|Capnocytophaga 976|Bacteroidetes L Belongs to the bacterial histone-like protein family hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_149339_1 984262.SGRA_2055 4.09e-11 68.2 COG0860@1|root,COG0860@2|Bacteria,4NGKC@976|Bacteroidetes,1ISH9@117747|Sphingobacteriia 976|Bacteroidetes M Cell wall hydrolase autolysin amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_71583_2 305700.B447_00165 1.22e-05 47.8 2EBX9@1|root,335WM@2|Bacteria,1NCDM@1224|Proteobacteria,2VYXB@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_104059_1 1169143.KB911041_gene636 2.16e-31 114.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,1JZT7@119060|Burkholderiaceae 28216|Betaproteobacteria E Acetolactate synthase, small subunit ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_104059_2 1255043.TVNIR_3223 1.55e-26 105.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_78292_1 3659.XP_004151350.1 7.07e-08 52.8 COG0021@1|root,KOG0523@2759|Eukaryota,37Q0E@33090|Viridiplantae,3G9CH@35493|Streptophyta,4JMVS@91835|fabids 35493|Streptophyta G Transketolase - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_110580_1 270374.MELB17_21330 1.19e-59 186.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,46851@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3436 Transposase and inactivated derivatives - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_110580_3 314278.NB231_08315 6.6e-64 202.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_110580_5 715451.ambt_21965 1.46e-22 90.5 COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,1S4IJ@1236|Gammaproteobacteria,4675K@72275|Alteromonadaceae 1236|Gammaproteobacteria K transcription regulator containing HTH domain - - - ko:K18831 - - - - ko00000,ko02048,ko03000 - - - HTH_3,Peptidase_M78 k59_65161_2 316067.Geob_2060 5.78e-79 240.0 COG4403@1|root,COG4403@2|Bacteria,1NCPK@1224|Proteobacteria,42Y4E@68525|delta/epsilon subdivisions,2WT9F@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Lanthionine synthetase C family protein - - - - - - - - - - - - - k59_201401_1 316274.Haur_2048 7.85e-52 171.0 COG4974@1|root,COG4974@2|Bacteria,2G7RJ@200795|Chloroflexi,376XZ@32061|Chloroflexia 32061|Chloroflexia L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_26358_1 743721.Psesu_0632 1.74e-61 200.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1X2YP@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_13322_1 1049564.TevJSym_ba00280 5.17e-150 430.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1J57D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II yfdZ GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K14261 - - - - ko00000,ko01000,ko01007 - - iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405 Aminotran_1_2 k59_149493_1 1283300.ATXB01000001_gene1382 1.07e-73 224.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1XF3U@135618|Methylococcales 135618|Methylococcales S PFAM Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_181878_1 933262.AXAM01000013_gene1290 3.78e-41 146.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2WN8T@28221|Deltaproteobacteria,2MJWP@213118|Desulfobacterales 28221|Deltaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_6905_3 1121405.dsmv_2774 8.46e-113 344.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_45716_4 1206732.BAGD01000280_gene6507 1.86e-10 59.3 2AFEW@1|root,315EW@2|Bacteria,2HJS6@201174|Actinobacteria,4G79Z@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_181881_1 525897.Dbac_0328 5.44e-39 147.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM Mammalian cell entry related domain protein pqiB - - ko:K06192 - - - - ko00000 - - - MlaD k59_19818_1 697282.Mettu_3537 2.45e-98 293.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1XG1T@135618|Methylococcales 135618|Methylococcales S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - - - - - - - - - - LigB k59_433_1 396588.Tgr7_0371 7.79e-46 155.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SASG@1236|Gammaproteobacteria,1WYFK@135613|Chromatiales 135613|Chromatiales CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Redoxin k59_32761_1 349521.HCH_05410 6.29e-31 118.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,1XIZT@135619|Oceanospirillales 135619|Oceanospirillales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_32761_2 1123053.AUDG01000023_gene644 5.87e-38 137.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RS50@1236|Gammaproteobacteria,1WXPC@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_162467_1 589924.Ferp_2487 6.89e-48 163.0 COG0123@1|root,arCOG00324@2157|Archaea,2Y2ST@28890|Euryarchaeota,246Y4@183980|Archaeoglobi 183980|Archaeoglobi BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_194779_1 96561.Dole_0493 7.07e-57 192.0 COG3233@1|root,COG3233@2|Bacteria,1RB7V@1224|Proteobacteria,42RBC@68525|delta/epsilon subdivisions,2WMQB@28221|Deltaproteobacteria,2MJK1@213118|Desulfobacterales 28221|Deltaproteobacteria S deacetylase - - - - - - - - - - - - - k59_201404_1 749414.SBI_01723 3.91e-59 199.0 COG1611@1|root,COG1611@2|Bacteria,2GMM1@201174|Actinobacteria 201174|Actinobacteria L Belongs to the LOG family yvdD - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Lysine_decarbox,NUDIX k59_175360_1 1123228.AUIH01000121_gene3493 1.19e-63 212.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1XIK6@135619|Oceanospirillales 135619|Oceanospirillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_58783_1 105559.Nwat_1280 1.68e-57 191.0 COG0707@1|root,COG0707@2|Bacteria,1QW3F@1224|Proteobacteria,1T2RC@1236|Gammaproteobacteria,1X2NR@135613|Chromatiales 135613|Chromatiales M Glycosyl transferase family 1 - - - - - - - - - - - - - k59_22419_1 1192034.CAP_6495 3.08e-26 107.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2YUXM@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.21,5.4.99.22 ko:K06178,ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_22419_2 1379858.N508_01474 1.05e-17 82.0 COG1386@1|root,COG1386@2|Bacteria,2GFFF@200930|Deferribacteres 200930|Deferribacteres D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_177965_1 335543.Sfum_3202 3.04e-94 286.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2MQX5@213462|Syntrophobacterales 28221|Deltaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_112994_1 477228.YO5_09550 5.48e-89 281.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1Z0GI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Belongs to the 5'-nucleotidase family yhcR - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_203680_1 1049564.TevJSym_bn00070 2.03e-143 412.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1J4CV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_203680_2 379731.PST_3955 3.56e-42 154.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1Z00S@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG0810 Periplasmic protein TonB, links inner and outer membranes tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_203680_3 631362.Thi970DRAFT_03627 0.000107 43.1 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales 135613|Chromatiales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_73757_1 242619.PG_0054 7.85e-41 152.0 COG0608@1|root,COG0608@2|Bacteria,4NDW1@976|Bacteroidetes,2FMH0@200643|Bacteroidia,22WD4@171551|Porphyromonadaceae 976|Bacteroidetes L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_112995_1 1249627.D779_3408 2.07e-26 100.0 COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,1S6R9@1236|Gammaproteobacteria,1WYV9@135613|Chromatiales 135613|Chromatiales O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly ureE - - ko:K03187 - - - - ko00000 - - - UreE_C,UreE_N k59_9326_1 323261.Noc_2824 1.52e-136 392.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales 135613|Chromatiales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_138610_1 1049564.TevJSym_aw00160 4.3e-48 155.0 COG2168@1|root,COG2168@2|Bacteria 2|Bacteria P tRNA wobble position uridine thiolation tusB GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_138610_2 1049564.TevJSym_aw00170 2.49e-57 180.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the DsrF TusC family tusC GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_61211_1 349124.Hhal_1233 1.09e-60 194.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales 135613|Chromatiales IQ PFAM Short-chain dehydrogenase reductase SDR fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_61211_2 1049564.TevJSym_bc00140 3.58e-140 405.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1J5AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0331 (acyl-carrier-protein) S-malonyltransferase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Acyl_transf_1 k59_126373_1 713586.KB900536_gene2999 3.05e-207 592.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1SZ84@1236|Gammaproteobacteria,1WXUW@135613|Chromatiales 135613|Chromatiales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_126373_2 396588.Tgr7_0948 1.53e-35 132.0 COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,1T20G@1236|Gammaproteobacteria 1236|Gammaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_158308_1 675635.Psed_4515 2.63e-14 74.3 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4E1WA@85010|Pseudonocardiales 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_93984_2 1121451.DESAM_20763 1.39e-07 53.9 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QAG@68525|delta/epsilon subdivisions,2X5DT@28221|Deltaproteobacteria,2MGPX@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_15275_1 292415.Tbd_2456 1.75e-72 229.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,1KRF9@119069|Hydrogenophilales 119069|Hydrogenophilales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_15275_2 1049564.TevJSym_ao00440 4.26e-29 106.0 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1J6UC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_184647_1 648996.Theam_1545 8.86e-37 127.0 COG0335@1|root,COG0335@2|Bacteria,2G450@200783|Aquificae 200783|Aquificae J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_184647_2 439235.Dalk_4643 8.38e-33 120.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria,2MJIK@213118|Desulfobacterales 28221|Deltaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DUF208,RNase_HII k59_171533_1 335543.Sfum_1168 3.28e-64 201.0 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MRMB@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_145522_2 396588.Tgr7_0271 9.84e-16 90.9 COG2133@1|root,COG2133@2|Bacteria,1R65J@1224|Proteobacteria,1RYQV@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Large extracellular alpha-helical protein - - - - - - - - - - - - - k59_145522_3 1123248.KB893315_gene3114 0.000353 49.7 COG0566@1|root,COG0566@2|Bacteria,4NF6H@976|Bacteroidetes,1IRFD@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family trmH - 2.1.1.185 ko:K03218,ko:K03437 - - - - ko00000,ko01000,ko03009,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_145522_4 748247.AZKH_1520 1.54e-288 798.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,2KUQY@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator Superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_145522_5 748247.AZKH_1521 1.5e-189 540.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,2KUUB@206389|Rhodocyclales 206389|Rhodocyclales V Biotin-lipoyl like - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_145522_6 748247.AZKH_1522 5.62e-218 617.0 COG1538@1|root,COG1538@2|Bacteria,1MUZZ@1224|Proteobacteria,2VH6M@28216|Betaproteobacteria,2KW8S@206389|Rhodocyclales 206389|Rhodocyclales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_145522_9 1395571.TMS3_0124845 1.32e-91 270.0 COG0454@1|root,COG0456@2|Bacteria,1N009@1224|Proteobacteria,1S2EE@1236|Gammaproteobacteria 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_145522_10 1380358.JADJ01000013_gene3348 2.31e-47 153.0 COG4453@1|root,COG4453@2|Bacteria,1PW13@1224|Proteobacteria,1TEVB@1236|Gammaproteobacteria,1XQFT@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1778) - - - - - - - - - - - - DUF1778 k59_145522_11 351348.Maqu_0568 1.71e-88 289.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,1RQFM@1236|Gammaproteobacteria,464N1@72275|Alteromonadaceae 1236|Gammaproteobacteria L ATPase involved in DNA repair sbcC GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576,GO:1990238 - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,AAA_29,SbcCD_C k59_48126_4 981223.AIED01000046_gene1398 5.37e-12 66.6 COG2856@1|root,COG5499@1|root,COG2856@2|Bacteria,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,1TCAQ@1236|Gammaproteobacteria,3NQX0@468|Moraxellaceae 1236|Gammaproteobacteria EK Pfam:DUF955 - - - - - - - - - - - - Peptidase_M78 k59_2375_1 1121861.KB899953_gene2383 1.31e-70 233.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria,2JVBX@204441|Rhodospirillales 204441|Rhodospirillales HP MoeA C-terminal region (domain IV) - - - - - - - - - - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_73763_1 1121935.AQXX01000113_gene1460 7.09e-238 660.0 COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,1RYEY@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_106397_1 574087.Acear_1158 6.19e-88 273.0 COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,3WAG6@53433|Halanaerobiales 186801|Clostridia J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_67656_1 383372.Rcas_1004 1.7e-06 52.0 COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,375TJ@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_67656_2 1265505.ATUG01000001_gene4320 1.1e-54 179.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_22434_1 1265505.ATUG01000003_gene606 2.36e-90 283.0 COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2MJBB@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM DAHP synthetase I - - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,DAHP_synth_1,PDT k59_42181_2 1286170.RORB6_01290 5e-13 67.8 COG1018@1|root,COG1018@2|Bacteria,1N6XY@1224|Proteobacteria,1SC8M@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin yfaE GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006124,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0019538,GO:0022900,GO:0030091,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071704,GO:1901564 - ko:K11107 - - - - ko00000 - - - Fer2 k59_42181_4 396588.Tgr7_0851 5.73e-65 222.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X09E@135613|Chromatiales 135613|Chromatiales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_87021_1 768671.ThimaDRAFT_1486 2.19e-142 439.0 COG0438@1|root,COG0438@2|Bacteria,1N5HW@1224|Proteobacteria,1RPPH@1236|Gammaproteobacteria,1WY5F@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_190872_1 994573.T472_0217530 8.07e-37 141.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_9,PrpR_N,Sigma54_activat k59_196820_5 522373.Smlt3967 5.67e-61 203.0 COG1307@1|root,COG1307@2|Bacteria,1R5M9@1224|Proteobacteria,1RZYN@1236|Gammaproteobacteria,1XCQP@135614|Xanthomonadales 135614|Xanthomonadales S Uncharacterised protein, DegV family COG1307 - - - - - - - - - - - - DegV k59_196820_7 55952.BU52_01810 7.5e-06 53.9 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 k59_196820_8 1049564.TevJSym_bw00090 0.0 939.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1J5D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KL HELICc2 yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_196820_9 1049564.TevJSym_bw00100 9.45e-11 59.3 2C20N@1|root,32SGJ@2|Bacteria,1N3M9@1224|Proteobacteria,1S9VG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_2376_1 1121405.dsmv_3267 4.11e-152 441.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales 28221|Deltaproteobacteria J ribonuclease Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_113011_1 933262.AXAM01000032_gene686 1.98e-58 187.0 COG2974@1|root,COG2974@2|Bacteria,1RCUH@1224|Proteobacteria,42QVW@68525|delta/epsilon subdivisions,2WN5B@28221|Deltaproteobacteria,2MJPM@213118|Desulfobacterales 28221|Deltaproteobacteria L May be involved in recombination - - - - - - - - - - - - RdgC k59_113011_2 552811.Dehly_0555 3.11e-65 206.0 COG1515@1|root,COG1515@2|Bacteria,2G6SS@200795|Chloroflexi,34D8S@301297|Dehalococcoidia 301297|Dehalococcoidia L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_28674_2 1049564.TevJSym_by00020 8.11e-47 157.0 COG2980@1|root,COG2980@2|Bacteria,1PSFI@1224|Proteobacteria,1SE86@1236|Gammaproteobacteria,1J796@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_28674_3 1122194.AUHU01000004_gene1260 1.29e-90 282.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,466B8@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III, delta subunit holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_184653_1 323261.Noc_2818 4.17e-26 105.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,1X2NC@135613|Chromatiales 135613|Chromatiales J Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA - - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_126392_1 1121468.AUBR01000012_gene2599 2.02e-34 130.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia 186801|Clostridia C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_94005_1 313603.FB2170_14693 1.82e-19 89.7 COG1024@1|root,COG1024@2|Bacteria,4NK1J@976|Bacteroidetes,1IEGK@117743|Flavobacteriia,2PHUU@252356|Maribacter 976|Bacteroidetes I Enoyl-CoA hydratase/isomerase - - 4.2.1.17,5.3.3.8 ko:K01692,ko:K13238 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R04756,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_9347_1 621372.ACIH01000247_gene1402 1.3e-33 120.0 COG2363@1|root,COG2363@2|Bacteria,1VA79@1239|Firmicutes,4HKHG@91061|Bacilli,26Z1H@186822|Paenibacillaceae 91061|Bacilli S membrane ywdK - - - - - - - - - - - DUF423 k59_9347_2 1232437.KL662054_gene5504 1.86e-71 220.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,42QR5@68525|delta/epsilon subdivisions,2WMSR@28221|Deltaproteobacteria,2MJFW@213118|Desulfobacterales 28221|Deltaproteobacteria M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_42188_1 105559.Nwat_1650 3.61e-132 412.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales 135613|Chromatiales EO Peptidase family M28 - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_152097_3 1049564.TevJSym_an00760 3.48e-62 192.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1J68E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_99863_1 96561.Dole_3016 1.88e-59 202.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2WJ7J@28221|Deltaproteobacteria,2MNFB@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_94273_3 123899.JPQP01000004_gene646 2.55e-17 85.9 COG1802@1|root,COG1802@2|Bacteria,1PVIG@1224|Proteobacteria,2WEII@28216|Betaproteobacteria,3T4WI@506|Alcaligenaceae 28216|Betaproteobacteria K FCD domain - - - - - - - - - - - - FCD,GntR k59_94273_4 264198.Reut_B4869 1.36e-89 278.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VH71@28216|Betaproteobacteria,1K3ER@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family vdh - 1.2.1.67 ko:K21802 ko00627,ko01120,map00627,map01120 - R05699 RC00075 ko00000,ko00001,ko01000 - - - Aldedh k59_87248_1 335543.Sfum_3133 4.3e-83 274.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQVU@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_87248_2 1265505.ATUG01000003_gene623 1.41e-27 103.0 COG1908@1|root,COG1908@2|Bacteria,1RI0K@1224|Proteobacteria,42SSK@68525|delta/epsilon subdivisions,2WPF9@28221|Deltaproteobacteria,2MQ22@213118|Desulfobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_54582_1 177439.DP3020 6.1e-67 208.0 2DJ8V@1|root,3050U@2|Bacteria,1RE7U@1224|Proteobacteria 1224|Proteobacteria - - - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - - k59_54582_2 2340.JV46_14180 5.04e-136 428.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - 3.1.4.52 ko:K21024 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 k59_87250_1 66373.JOFQ01000007_gene3310 1.01e-07 56.6 COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria 201174|Actinobacteria GL phosphoglycerate mutase - - 3.1.26.4,3.1.3.73 ko:K02226,ko:K22316 ko00860,ko01100,ko03030,map00860,map01100,map03030 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000,ko03032 - - - His_Phos_1,RVT_3 k59_42415_1 933262.AXAM01000010_gene1395 2.5e-24 102.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MI9Q@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_171682_3 1177181.T9A_00672 2.08e-153 443.0 28IH6@1|root,2Z8IF@2|Bacteria,1R4Z0@1224|Proteobacteria,1RS34@1236|Gammaproteobacteria,1XNFU@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_73940_1 765913.ThidrDRAFT_2217 4.06e-101 303.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria,1WX99@135613|Chromatiales 135613|Chromatiales U Belongs to the binding-protein-dependent transport system permease family - - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_73940_2 1249627.D779_3419 7.1e-145 414.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,1WXAW@135613|Chromatiales 135613|Chromatiales S pfam abc - - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_73940_3 768671.ThimaDRAFT_3073 8.25e-75 229.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1WXQ7@135613|Chromatiales 135613|Chromatiales E ABC transporter - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_197064_1 349123.Lreu23DRAFT_3935 4.97e-13 67.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,4HH3H@91061|Bacilli,3F74P@33958|Lactobacillaceae 91061|Bacilli J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_44989_2 78245.Xaut_0227 2.83e-50 166.0 COG4995@1|root,COG4995@2|Bacteria,1N2CY@1224|Proteobacteria,2UVFX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_45228_1 876269.ARWA01000001_gene2538 2.74e-11 70.5 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_141077_1 1265505.ATUG01000002_gene1619 4.28e-49 177.0 COG1148@1|root,COG2204@1|root,COG1148@2|Bacteria,COG2204@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MI9Y@213118|Desulfobacterales 28221|Deltaproteobacteria CT NAD(P)-binding Rossmann-like domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FAD_oxidored,Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2,Response_reg k59_147833_1 997296.PB1_13459 6.51e-14 73.2 COG0861@1|root,COG0861@2|Bacteria,1UVIJ@1239|Firmicutes,4HEYG@91061|Bacilli,1ZQM8@1386|Bacillus 91061|Bacilli P COG0861 Membrane protein TerC, possibly involved in tellurium resistance yceF - - - - - - - - - - - TerC k59_70502_1 765420.OSCT_1523 9.07e-70 219.0 COG0384@1|root,COG0384@2|Bacteria,2G7XR@200795|Chloroflexi,377M3@32061|Chloroflexia 32061|Chloroflexia S PFAM Phenazine biosynthesis PhzC PhzF protein - - - - - - - - - - - - PhzC-PhzF k59_63803_1 1049564.TevJSym_by00060 7.69e-41 136.0 2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,1SDCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_63803_2 2340.JV46_23230 2.22e-209 585.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1J4NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_109125_1 870187.Thini_3587 5.64e-114 352.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,462AE@72273|Thiotrichales 72273|Thiotrichales L PFAM Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_45235_1 96561.Dole_0163 4.57e-80 261.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2WJ4X@28221|Deltaproteobacteria,2MI7A@213118|Desulfobacterales 28221|Deltaproteobacteria K RNA binding S1 domain protein tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_76037_1 883067.HMPREF9237_00910 1.59e-32 126.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4D3VN@85005|Actinomycetales 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_76037_4 1121033.AUCF01000037_gene3924 2.31e-64 217.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria,2JVBX@204441|Rhodospirillales 204441|Rhodospirillales HP MoeA C-terminal region (domain IV) - - - - - - - - - - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_115210_1 1123504.JQKD01000016_gene1960 1.74e-16 78.2 29Q66@1|root,30B54@2|Bacteria,1N9YZ@1224|Proteobacteria,2VUIM@28216|Betaproteobacteria,4AHAV@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4166) - - - - - - - - - - - - DUF4166 k59_147847_1 1049564.TevJSym_ao00710 1.91e-30 116.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1J4JQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_147847_2 1049564.TevJSym_ao00700 3.72e-50 170.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1J4FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG2951 Membrane-bound lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_70525_2 1121921.KB898707_gene1037 1.05e-14 72.8 28P60@1|root,2ZC0V@2|Bacteria,1RC8V@1224|Proteobacteria,1S29Y@1236|Gammaproteobacteria,2PN88@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Domain of unknown function (DUF4194) - - - - - - - - - - - - DUF4194 k59_173129_2 706587.Desti_4204 3.77e-66 214.0 COG0467@1|root,COG1476@1|root,COG1917@1|root,COG0467@2|Bacteria,COG1476@2|Bacteria,COG1917@2|Bacteria,1PE60@1224|Proteobacteria,42NFD@68525|delta/epsilon subdivisions,2WK1C@28221|Deltaproteobacteria,2MQST@213462|Syntrophobacterales 28221|Deltaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_101985_1 1121403.AUCV01000008_gene1581 7.31e-10 59.3 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MHVD@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_109139_1 555779.Dthio_PD2605 2.92e-36 137.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_192944_1 1049564.TevJSym_at00120 3.25e-156 448.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,1RPND@1236|Gammaproteobacteria,1J945@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S TraB family traB - - - - - - - - - - - TraB k59_192944_2 1049564.TevJSym_at00110 1.34e-164 476.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1J53S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_167044_1 1454202.PPBDW_130493___1 2.2e-21 92.0 2BYAF@1|root,2ZWH8@2|Bacteria,1RBZ8@1224|Proteobacteria,1S3VD@1236|Gammaproteobacteria,1Y29R@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF3581) SO4011 - - - - - - - - - - - DUF3581 k59_45258_1 941449.dsx2_1445 4.96e-99 297.0 COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,42QQ7@68525|delta/epsilon subdivisions,2WN8Z@28221|Deltaproteobacteria,2M8UD@213115|Desulfovibrionales 28221|Deltaproteobacteria M Linear amide C-N hydrolases, choloylglycine hydrolase family - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_154004_1 1408419.JHYG01000015_gene2540 1.06e-10 63.2 COG3515@1|root,COG3515@2|Bacteria,1MY80@1224|Proteobacteria,2U5MC@28211|Alphaproteobacteria,2JU9I@204441|Rhodospirillales 204441|Rhodospirillales S ImpA, N-terminal, type VI secretion system - - - ko:K11902 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - ImpA_N k59_17526_3 335543.Sfum_2372 1.68e-21 99.8 COG0535@1|root,COG0535@2|Bacteria,1MYFX@1224|Proteobacteria,42SB0@68525|delta/epsilon subdivisions,2WPF4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_70538_1 177437.HRM2_00660 3.45e-135 417.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,2MN0V@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_192945_1 1122201.AUAZ01000004_gene3440 3.94e-93 293.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,4659W@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1061 DNA or RNA helicases of superfamily II - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_199123_1 1095749.HMPREF1052_1400 2.78e-26 112.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,1RPQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria N type VI secretion protein icmF - - ko:K11891,ko:K12210 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1,3.A.7.9.1 - - IcmF-related,IcmF_C,ImcF-related_N k59_199123_3 1049564.TevJSym_ad00200 1.1e-59 196.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1S4U5@1236|Gammaproteobacteria,1JBTQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K11890,ko:K20074 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01009,ko02044 - - - PP2C_2 k59_63805_4 857087.Metme_1348 8.91e-35 124.0 COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,1S271@1236|Gammaproteobacteria,1XEEV@135618|Methylococcales 135618|Methylococcales S small GTP-binding protein - - - ko:K06945 - - - - ko00000 - - - ATP_bind_1 k59_109147_2 686340.Metal_0471 3.19e-52 173.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1XEXJ@135618|Methylococcales 135618|Methylococcales K PFAM HTH transcriptional regulator, LysR - - - - - - - - - - - - HTH_1,LysR_substrate k59_160947_1 1049564.TevJSym_bl00110 3.97e-115 339.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1J4FV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NAD(P) transhydrogenase, alpha subunit pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_45264_1 439235.Dalk_1317 1.6e-84 263.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_96802_1 1167006.UWK_00556 1.26e-70 224.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1 k59_101993_1 1205753.A989_06868 5.28e-152 441.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1X38S@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18298,ko:K19586 - M00641,M00767 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.47,8.A.1 - - Biotin_lipoyl_2,HlyD_D23 k59_141105_2 1218075.BAYA01000044_gene6616 1.61e-13 75.1 COG1752@1|root,COG2303@1|root,COG1752@2|Bacteria,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1KGJC@119060|Burkholderiaceae 28216|Betaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_63807_1 228410.NE0901 4.04e-51 184.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2WEJA@28216|Betaproteobacteria,374P7@32003|Nitrosomonadales 28216|Betaproteobacteria EO pdz dhr glgf - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_154011_1 604331.AUHY01000074_gene1811 2.96e-95 290.0 COG3328@1|root,COG3328@2|Bacteria,1WN6I@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L MULE transposase domain - - - - - - - - - - - - Transposase_mut k59_50587_1 388401.RB2150_02584 1.84e-130 382.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3ZI18@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria L L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve,rve_3 k59_180238_1 1167006.UWK_01205 3.4e-218 632.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_180238_3 1049564.TevJSym_ai00620 5.38e-121 355.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P sulfurtransferase - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_180238_4 1158146.KB907121_gene1104 3.86e-135 395.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales 135613|Chromatiales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_180238_7 870187.Thini_0365 1.71e-71 221.0 COG4636@1|root,COG4636@2|Bacteria,1RID4@1224|Proteobacteria,1S8MU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative restriction endonuclease - - - - - - - - - - - - Uma2 k59_180238_11 1452718.JBOY01000204_gene2871 6.17e-11 70.5 COG3301@1|root,COG3301@2|Bacteria,1QU9J@1224|Proteobacteria,1T1VQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P reductase ttrC - - ko:K08359 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - NrfD k59_122728_1 335543.Sfum_3278 1.81e-78 244.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,2MR0X@213462|Syntrophobacterales 28221|Deltaproteobacteria F PFAM AIR synthase related protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1844 AIRS,AIRS_C k59_70549_2 1131553.JIBI01000011_gene751 5.99e-27 103.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,37305@32003|Nitrosomonadales 28216|Betaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_56339_1 96561.Dole_0073 2.04e-52 173.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MJ9I@213118|Desulfobacterales 28221|Deltaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,CoA_binding,Ligase_CoA k59_56339_2 1230341.MJ3_02567 3.44e-29 114.0 COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli 91061|Bacilli C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU16090 ATP-grasp_2,Ligase_CoA k59_141114_1 1298593.TOL_2288 2.77e-33 125.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1XISZ@135619|Oceanospirillales 135619|Oceanospirillales E Prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_141114_2 1049564.TevJSym_ad01440 8.96e-82 253.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1J5KH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_205872_1 673860.AciM339_0002 1.78e-07 58.5 COG0681@1|root,arCOG01739@2157|Archaea,2Y6XH@28890|Euryarchaeota,3F2QN@33867|unclassified Euryarchaeota 28890|Euryarchaeota U Signal peptidase - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - - k59_199352_2 1260251.SPISAL_08245 1.53e-13 68.9 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1WY36@135613|Chromatiales 135613|Chromatiales E PFAM lipolytic protein G-D-S-L family - - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_115457_1 648757.Rvan_1109 1.34e-33 130.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,3N69K@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_122983_2 161156.JQKW01000011_gene983 6.41e-40 154.0 COG0303@1|root,COG0303@2|Bacteria,2GGXT@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H MoeA C-terminal region (domain IV) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_38267_5 1280944.HY17_16865 4.32e-12 66.6 COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2UA2S@28211|Alphaproteobacteria,440A6@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_38267_6 580332.Slit_2330 5.03e-170 481.0 COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VSAQ@28216|Betaproteobacteria,44W4Q@713636|Nitrosomonadales 28216|Betaproteobacteria S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt k59_109355_1 339670.Bamb_5254 2.76e-88 267.0 COG1262@1|root,COG1262@2|Bacteria,1MVJG@1224|Proteobacteria,2VPX5@28216|Betaproteobacteria 28216|Betaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_167284_1 1049564.TevJSym_ab01650 1.38e-95 309.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1J54G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_154321_1 1288963.ADIS_4388 1.32e-91 281.0 COG4948@1|root,COG4948@2|Bacteria,4NI24@976|Bacteroidetes,47N24@768503|Cytophagia 976|Bacteroidetes M mandelate racemase muconate lactonizing - - 4.2.1.8 ko:K08323 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_206088_1 439235.Dalk_4695 1.03e-187 547.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42NQY@68525|delta/epsilon subdivisions,2WISG@28221|Deltaproteobacteria,2MIXC@213118|Desulfobacterales 28221|Deltaproteobacteria HP MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_199365_1 1049564.TevJSym_ay00260 4.06e-186 534.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_97060_2 1485545.JQLW01000005_gene912 2.78e-180 509.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria 1224|Proteobacteria C small subunit hupU - 1.12.7.2 ko:K00534 - - R00019 - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_97060_3 420662.Mpe_A2806 3.23e-54 183.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VKZS@28216|Betaproteobacteria,1KIZV@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nickel-dependent hydrogenase hoxC - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_40263_2 1131451.O1K_17353 1.88e-20 99.8 COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1X535@135614|Xanthomonadales 135614|Xanthomonadales I LssY C-terminus - - - - - - - - - - - - LssY_C,PAP2,SNARE_assoc k59_118157_1 335543.Sfum_2498 4.62e-48 166.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42PIT@68525|delta/epsilon subdivisions,2WKT1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M COG4591 ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_176340_1 335543.Sfum_2307 1.12e-28 118.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1PFBE@1224|Proteobacteria,42YSB@68525|delta/epsilon subdivisions,2WU00@28221|Deltaproteobacteria,2MR36@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HisKA k59_202391_1 1049564.TevJSym_aj00540 1.2e-158 448.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1J8PV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Phosphoribulokinase / Uridine kinase family prkB GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_170058_1 933262.AXAM01000041_gene1897 2.78e-88 280.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MINC@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_150553_1 1449049.JONW01000005_gene1430 1.32e-56 184.0 COG3757@1|root,COG3757@2|Bacteria,1PYUJ@1224|Proteobacteria,2V9ZM@28211|Alphaproteobacteria,2KJM4@204458|Caulobacterales 204458|Caulobacterales M Glycosyl hydrolases family 25 - - - - - - - - - - - - Glyco_hydro_25 k59_150553_2 391587.KAOT1_02487 2.09e-06 48.1 2BI4W@1|root,3323T@2|Bacteria 2|Bacteria S RebB like protein - - - - - - - - - - - - RebB k59_33801_1 443144.GM21_0781 2.7e-123 366.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43TA3@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_20786_1 1047013.AQSP01000089_gene1175 4.93e-65 210.0 COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria 2|Bacteria E Cys/Met metabolism PLP-dependent enzyme metC - 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_53143_3 999141.GME_02500 6.22e-62 195.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XPF5@135619|Oceanospirillales 135619|Oceanospirillales O methionine sulfoxide reductase - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_53143_4 398527.Bphyt_1683 0.0 1179.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VICN@28216|Betaproteobacteria,1K3Q3@119060|Burkholderiaceae 28216|Betaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Pkinase k59_156911_1 706587.Desti_3417 4.93e-34 122.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WNF6@28221|Deltaproteobacteria,2MRJ8@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_156911_2 96561.Dole_2642 4.93e-54 172.0 COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,2MKAV@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_79429_1 485913.Krac_8702 1.2e-76 253.0 COG3464@1|root,COG3464@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - UPF0236 k59_66078_1 1288484.APCS01000001_gene571 6.08e-15 76.3 COG0789@1|root,COG0789@2|Bacteria,1WJ4G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K PFAM MerR family regulatory protein - - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 k59_1160_1 637390.AFOH01000012_gene676 4.88e-48 154.0 COG3077@1|root,COG3077@2|Bacteria,1N73E@1224|Proteobacteria,1SA1Y@1236|Gammaproteobacteria,2NDW7@225057|Acidithiobacillales 225057|Acidithiobacillales L RelB antitoxin - - - ko:K07473 - - - - ko00000,ko02048 - - - RelB k59_1160_2 1226994.AMZB01000108_gene1877 5.73e-56 174.0 COG3041@1|root,COG3041@2|Bacteria,1N0K0@1224|Proteobacteria,1SB57@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial toxin of type II toxin-antitoxin system, YafQ - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0034655,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576 - ko:K19157 - - - - ko00000,ko01000,ko02048 - - - YafQ_toxin k59_118167_1 1121468.AUBR01000007_gene254 9.66e-63 204.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,42FTZ@68295|Thermoanaerobacterales 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_111602_1 1232437.KL662058_gene3954 7.21e-19 91.3 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2MIJB@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_163424_1 1047013.AQSP01000110_gene67 5.59e-77 241.0 COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria 2|Bacteria P CorA-like Mg2+ transporter protein corA GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_27333_1 1121448.DGI_2245 8.09e-66 214.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,42VAM@68525|delta/epsilon subdivisions,2WRK9@28221|Deltaproteobacteria,2MGFU@213115|Desulfovibrionales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_66081_1 153721.MYP_801 2.14e-55 192.0 COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes,47MKQ@768503|Cytophagia 976|Bacteroidetes K TIGRFAM competence protein ComEA helix-hairpin-helix repeat region yhgF - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_189465_1 749414.SBI_09336 2.47e-103 313.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_29,HTH_32 k59_137332_1 742159.HMPREF0004_4156 6.59e-57 186.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,3T3A0@506|Alcaligenaceae 28216|Betaproteobacteria E ABC-type branched-chain amino acid transport systems ATPase component livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_104976_2 1122201.AUAZ01000004_gene3440 4.1e-165 477.0 COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,4659W@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1061 DNA or RNA helicases of superfamily II - - - - - - - - - - - - Helicase_C,ResIII,UPF0547 k59_111605_1 933262.AXAM01000033_gene1619 8.27e-123 368.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2MI8Q@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_85609_1 713587.THITH_06775 7.89e-34 121.0 COG0680@1|root,COG0680@2|Bacteria,1RGFM@1224|Proteobacteria,1S4XN@1236|Gammaproteobacteria,1WY9T@135613|Chromatiales 135613|Chromatiales C PFAM Peptidase A31, hydrogen uptake protein - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_85609_2 1249627.D779_1107 1.09e-25 101.0 2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria,1WYS0@135613|Chromatiales 135613|Chromatiales S PFAM HupH hydrogenase expression protein, C-terminal conserved region - - - ko:K03618 - - - - ko00000 - - - HupH_C k59_131195_1 237368.SCABRO_02100 2.17e-54 174.0 COG4276@1|root,COG4276@2|Bacteria,2J0FI@203682|Planctomycetes 203682|Planctomycetes S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_53148_1 1125863.JAFN01000001_gene1162 5.62e-156 445.0 COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,42RI3@68525|delta/epsilon subdivisions,2WNVC@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_53148_2 335543.Sfum_3397 5.93e-42 144.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42YMD@68525|delta/epsilon subdivisions,2WUG7@28221|Deltaproteobacteria,2MRMN@213462|Syntrophobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_156920_1 568768.CM001975_gene3418 4.85e-05 50.8 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,2JD9F@204037|Dickeya 1236|Gammaproteobacteria V MacB-like periplasmic core domain macB_1 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_156920_2 1117647.M5M_16045 3.12e-06 48.5 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RQW0@1236|Gammaproteobacteria,1J885@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_1164_1 1049564.TevJSym_ba00210 3.88e-111 347.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1J51H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_124631_1 1203606.HMPREF1526_02176 3.15e-43 159.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,36DX4@31979|Clostridiaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind k59_156922_1 640081.Dsui_2204 1.63e-102 318.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,2KU6I@206389|Rhodocyclales 206389|Rhodocyclales E extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_163431_1 673860.AciM339_1568 1.07e-69 220.0 COG1378@1|root,arCOG02038@2157|Archaea,2Y7FZ@28890|Euryarchaeota,3F2ZR@33867|unclassified Euryarchaeota 28890|Euryarchaeota K Archaeal transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB k59_163431_2 1297617.JPJD01000028_gene2272 7.49e-07 50.8 COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,268GF@186813|unclassified Clostridiales 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_66090_1 1304885.AUEY01000032_gene1991 1.36e-80 265.0 COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function DUF89 - - - - - - - - - - - - DUF89 k59_170094_1 643562.Daes_1749 5.81e-59 190.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WNES@28221|Deltaproteobacteria,2M82V@213115|Desulfovibrionales 28221|Deltaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_72607_1 1029823.AFIE01000009_gene1728 1.03e-65 209.0 COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,3NNMV@468|Moraxellaceae 1236|Gammaproteobacteria Q response to metal ion tpm - 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT k59_72607_2 261292.Nit79A3_1503 4.74e-68 209.0 COG0789@1|root,COG0789@2|Bacteria,1RGW6@1224|Proteobacteria,2VRHE@28216|Betaproteobacteria 28216|Betaproteobacteria K regulatory protein, MerR - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_72607_3 1049564.TevJSym_ad00360 1.39e-44 150.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1J702@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TerB k59_202412_1 335543.Sfum_0614 2.92e-87 265.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - - - - - - - - - - CN_hydrolase k59_92174_1 1123401.JHYQ01000007_gene542 2.68e-85 276.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales 72273|Thiotrichales C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1174_1 1123393.KB891332_gene2797 9.02e-15 67.8 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,1KRWR@119069|Hydrogenophilales 119069|Hydrogenophilales C ATP synthase subunit C - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1174_2 1049564.TevJSym_aq00420 3.33e-64 200.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,1J5YT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_183014_1 572477.Alvin_2728 1.21e-28 109.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1WW65@135613|Chromatiales 135613|Chromatiales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_183014_3 1049564.TevJSym_bv00140 1.47e-113 331.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1J4MF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_183014_4 1395587.P364_0127715 8.14e-19 88.6 COG4619@1|root,COG4619@2|Bacteria,1V3DQ@1239|Firmicutes,4HHGU@91061|Bacilli,26WRY@186822|Paenibacillaceae 91061|Bacilli S ABC transporter ybbL - - ko:K02068 - M00211 - - ko00000,ko00002,ko02000 - - - ABC_tran k59_183014_5 1049564.TevJSym_bv00160 2.11e-128 372.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1J73F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0014) ybbM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0015075,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0030003,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098771 - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_183014_6 1049564.TevJSym_aw00660 2e-20 83.6 2EIMJ@1|root,33CCU@2|Bacteria,1NMXZ@1224|Proteobacteria,1SHQA@1236|Gammaproteobacteria,1J797@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_183014_7 546274.EIKCOROL_01800 3.43e-67 210.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,2KR3W@206351|Neisseriales 206351|Neisseriales S Macro domain protein - - - - - - - - - - - - Macro k59_183014_8 1049564.TevJSym_ag00040 8.37e-41 137.0 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,1SGKD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_104989_1 1049564.TevJSym_ak00970 3.43e-34 121.0 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1J6Z2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_98400_3 1265313.HRUBRA_01716 2.1e-231 645.0 COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,1RPQR@1236|Gammaproteobacteria,1JBCV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pfam:HipA_N hipA_1 - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_98400_4 1265313.HRUBRA_01717 5.42e-37 127.0 COG1396@1|root,COG1396@2|Bacteria,1NGFD@1224|Proteobacteria,1SGW1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_98400_5 911239.CF149_10688 7.44e-32 119.0 COG1028@1|root,COG1028@2|Bacteria,1MUYD@1224|Proteobacteria,1S25F@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_98400_6 1173028.ANKO01000215_gene6243 5.8e-05 48.5 COG1595@1|root,COG1595@2|Bacteria,1G687@1117|Cyanobacteria,1HB9J@1150|Oscillatoriales 1117|Cyanobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_98400_10 247633.GP2143_02944 1.27e-14 74.7 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1J81D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_98400_11 85643.Tmz1t_0471 1.36e-167 481.0 COG3177@1|root,COG3177@2|Bacteria,1RDDR@1224|Proteobacteria 1224|Proteobacteria S Fic/DOC family - - - - - - - - - - - - Fic k59_33829_1 377629.TERTU_1656 4.53e-93 286.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria,2PQ0I@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Type VI secretion protein, EvpB/VC_A0108, tail sheath impC - - ko:K11899,ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_131210_1 1123296.JQKE01000071_gene1834 2.65e-57 201.0 COG4643@1|root,COG4643@2|Bacteria,1QTXN@1224|Proteobacteria,2VM6N@28216|Betaproteobacteria,2KQCJ@206351|Neisseriales 206351|Neisseriales S Primase C terminal 2 (PriCT-2) - - - ko:K06919 - - - - ko00000 - - - PriCT_2,Toprim_3 k59_79458_1 948106.AWZT01000060_gene3382 8.11e-101 310.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,1K4VW@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_144153_1 1192034.CAP_0159 3.13e-20 93.6 COG0515@1|root,COG2203@1|root,COG3829@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory protein, Fis family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat k59_189487_1 925409.KI911562_gene1825 4.04e-21 90.9 COG5654@1|root,COG5654@2|Bacteria,4NTUP@976|Bacteroidetes,1IZ2I@117747|Sphingobacteriia 976|Bacteroidetes S RES - - - - - - - - - - - - RES k59_189487_2 743299.Acife_1680 2.98e-23 96.7 COG5642@1|root,COG5642@2|Bacteria,1NAEY@1224|Proteobacteria,1T188@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_202418_1 398767.Glov_2305 6.81e-24 100.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_40380_1 880072.Desac_0499 8.84e-86 266.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_189488_1 868595.Desca_2711 7.27e-24 98.2 COG2606@1|root,COG2606@2|Bacteria,1V3MU@1239|Firmicutes,24HH2@186801|Clostridia,261Y6@186807|Peptococcaceae 186801|Clostridia S PFAM YbaK prolyl-tRNA synthetases associated domain EbsC - - - - - - - - - - - tRNA_edit k59_85617_1 1260251.SPISAL_05925 1.92e-12 68.2 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales 135613|Chromatiales D Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - SulA k59_85617_2 243233.MCA2165 1.59e-91 295.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1XG5F@135618|Methylococcales 135618|Methylococcales L impB/mucB/samB family - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_203886_4 246196.MSMEI_4902 7.2e-31 125.0 COG2141@1|root,COG2141@2|Bacteria,2GJ66@201174|Actinobacteria,233JS@1762|Mycobacteriaceae 201174|Actinobacteria C Luciferase family limB_5 - - - - - - - - - - - Bac_luciferase k59_203886_5 272560.BPSS1191 1.53e-144 419.0 COG2515@1|root,COG2515@2|Bacteria 2|Bacteria E 1-aminocyclopropane-1-carboxylate deaminase activity dcyD - 3.5.99.7,4.4.1.15 ko:K01505,ko:K05396 ko00270,map00270 - R00997,R01874 RC00382,RC00419 ko00000,ko00001,ko01000 - - - PALP k59_203886_6 272560.BPSS1192 7.23e-108 332.0 2FJT0@1|root,34BFQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_152097_1 768671.ThimaDRAFT_4051 6.46e-151 441.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_152097_2 1201290.M902_1873 1.37e-40 146.0 COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2MT2H@213481|Bdellovibrionales,2WP5V@28221|Deltaproteobacteria 213481|Bdellovibrionales T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HAMP,HD,HD_5 k59_126943_1 1391646.AVSU01000122_gene1376 1.38e-48 167.0 COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia 186801|Clostridia P transporter zupT - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip k59_145944_1 1121405.dsmv_0618 9.97e-108 328.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales 28221|Deltaproteobacteria C reductase, alpha subunit aprA - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_22831_1 261292.Nit79A3_2501 2.04e-34 127.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHC7@28216|Betaproteobacteria,374M1@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Integrase, catalytic core - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_22831_2 443144.GM21_0401 7.05e-05 43.1 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,42WWI@68525|delta/epsilon subdivisions,2WSR8@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_48601_1 1265505.ATUG01000003_gene622 2.18e-63 218.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_48601_2 439235.Dalk_3266 9.97e-15 73.6 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIA4@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 k59_126945_1 1538644.KO02_13645 2.38e-15 75.9 COG3177@1|root,COG3177@2|Bacteria,4NF0H@976|Bacteroidetes,1IRF1@117747|Sphingobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4172) - - - - - - - - - - - - DUF4172,Fic k59_9813_2 498211.CJA_1206 2.17e-67 218.0 COG0612@1|root,COG0612@2|Bacteria,1MVSB@1224|Proteobacteria,1SA4C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase, M16 - - - - - - - - - - - - - k59_113348_4 1280686.AUKE01000030_gene1613 8.12e-07 60.1 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,4BY6B@830|Butyrivibrio 186801|Clostridia T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MASE3,Reg_prop,Response_reg k59_113348_5 1049564.TevJSym_bg00040 1.44e-95 309.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1J4ZR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_94574_1 65093.PCC7418_0604 1.31e-98 299.0 COG2873@1|root,COG2873@2|Bacteria,1G4EH@1117|Cyanobacteria 1117|Cyanobacteria E O-acetylhomoserine sulfhydrylase met17 - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_106903_1 383372.Rcas_0928 3.43e-87 275.0 COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi 200795|Chloroflexi L sptr a7nhu5 - - - - - - - - - - - - DDE_5 k59_68133_2 1121937.AUHJ01000002_gene3499 5.09e-42 156.0 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,466JS@72275|Alteromonadaceae 1236|Gammaproteobacteria N Belongs to the bacterial flagellin family flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_126950_1 1232437.KL661964_gene3336 1.44e-55 189.0 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM ResB family protein - - - ko:K07399 - - - - ko00000 - - - ResB k59_81207_1 273075.Ta0626m 8.19e-18 83.2 COG1014@1|root,arCOG01603@2157|Archaea,2XYDT@28890|Euryarchaeota,242E6@183967|Thermoplasmata 183967|Thermoplasmata C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_35795_1 2340.JV46_11590 2.3e-43 152.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_120315_1 1049564.TevJSym_at00750 3.53e-95 279.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,1RPVD@1236|Gammaproteobacteria,1J5R6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050355 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - iJN746.PP_0538,iPC815.YPO3521 Pyrophosphatase k59_120315_2 1049564.TevJSym_at00740 1.77e-97 286.0 COG0622@1|root,COG0622@2|Bacteria,1RCUQ@1224|Proteobacteria,1S2YE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_120315_3 1249627.D779_0329 4.11e-70 216.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1WY7V@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_120315_4 1121459.AQXE01000007_gene566 9.26e-12 65.9 COG0840@1|root,COG2703@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria,1RBB1@1224|Proteobacteria,42RNA@68525|delta/epsilon subdivisions,2WNGN@28221|Deltaproteobacteria,2MGVG@213115|Desulfovibrionales 28221|Deltaproteobacteria NPT PFAM chemotaxis - - - ko:K03406,ko:K07216 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Hemerythrin,MCPsignal,PilJ k59_61739_1 313628.LNTAR_24818 4.3e-55 185.0 COG3328@1|root,COG3328@2|Bacteria 2|Bacteria L transposase activity tnp - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_204091_1 1049564.TevJSym_av00200 9.23e-45 154.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,1SZZW@1236|Gammaproteobacteria,1JBZT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M UDP-N-acetylglucosamine 2-epimerase wecB - 5.1.3.14,5.1.3.23 ko:K01791,ko:K13019 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420,R09600 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_204091_2 1168067.JAGP01000001_gene2179 2.4e-33 126.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,460RS@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_2789_1 526218.Sterm_3835 6.09e-20 93.6 COG0246@1|root,COG0246@2|Bacteria 2|Bacteria G mannitol metabolic process - - 1.1.1.17 ko:K00009 ko00051,map00051 - R02703 RC00085 ko00000,ko00001,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_2789_2 1244869.H261_16336 2.23e-78 278.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,2TW0C@28211|Alphaproteobacteria,2JZ4C@204441|Rhodospirillales 204441|Rhodospirillales T COG0591 Na proline symporter - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg k59_2789_3 1049564.TevJSym_ak00240 4.44e-149 430.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1JBTU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_158798_1 641491.DND132_2503 1.75e-135 394.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42Q4I@68525|delta/epsilon subdivisions,2WIX3@28221|Deltaproteobacteria,2M9W3@213115|Desulfovibrionales 28221|Deltaproteobacteria E Catalyzes the interconversion of ornithine to glutamate semialdehyde rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_48617_1 1283300.ATXB01000001_gene1115 3.78e-36 124.0 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1XF9W@135618|Methylococcales 135618|Methylococcales E PFAM Phosphoribosyl-ATP pyrophosphohydrolase hisE GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_15641_1 377629.TERTU_4229 1.21e-47 167.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,1RNQP@1236|Gammaproteobacteria,2PPEY@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_197268_2 270374.MELB17_04547 7.11e-51 171.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,4666C@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0826 Collagenase and related proteases yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_171857_1 644282.Deba_1506 1.45e-12 73.6 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJ25@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_133110_1 765911.Thivi_3870 1.33e-64 207.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_133110_2 795666.MW7_2470 1.72e-10 60.8 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,1K1SH@119060|Burkholderiaceae 28216|Betaproteobacteria D Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_106917_1 1049564.TevJSym_ac01030 7.84e-102 306.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9BP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_2797_1 525146.Ddes_2317 5.15e-29 118.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2M80Z@213115|Desulfovibrionales 28221|Deltaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_145967_1 1239962.C943_02828 1.61e-51 181.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,4NGF6@976|Bacteroidetes 976|Bacteroidetes P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_9830_1 1049564.TevJSym_bh00080 1.36e-52 183.0 28JIE@1|root,2Z9BR@2|Bacteria,1R952@1224|Proteobacteria,1RRHU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD k59_120326_1 1123518.ARWI01000001_gene1966 2.62e-36 132.0 COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,462T6@72273|Thiotrichales 72273|Thiotrichales C Cytochrome c class I - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_120326_2 631362.Thi970DRAFT_00820 9.8e-32 117.0 2BAEQ@1|root,323V5@2|Bacteria,1RITE@1224|Proteobacteria,1S7U8@1236|Gammaproteobacteria,1WYRK@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_120326_3 640081.Dsui_0571 6.02e-06 46.2 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,2VUIX@28216|Betaproteobacteria,2KX48@206389|Rhodocyclales 206389|Rhodocyclales C Ferredoxin - - - - - - - - - - - - - k59_48618_1 1049564.TevJSym_aa00810 1.71e-37 134.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1J50V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008757,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0010340,GO:0016053,GO:0016740,GO:0016741,GO:0016787,GO:0016788,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032259,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0791,iSBO_1134.SBO_0664,iSFV_1184.SFV_0760,iSF_1195.SF0727,iSFxv_1172.SFxv_0792,iSSON_1240.SSON_0756,iS_1188.S0768,iSbBS512_1146.SbBS512_E2575 Methyltransf_11 k59_48618_3 768671.ThimaDRAFT_3354 5.6e-139 404.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_106918_1 1232437.KL661965_gene3219 1.41e-10 61.2 2ESCT@1|root,33JXK@2|Bacteria,1NK92@1224|Proteobacteria,42Y2H@68525|delta/epsilon subdivisions,2WSPA@28221|Deltaproteobacteria,2MM9Z@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_106918_2 1265505.ATUG01000001_gene3096 2.35e-65 204.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42QS2@68525|delta/epsilon subdivisions,2WMXG@28221|Deltaproteobacteria,2MJMH@213118|Desulfobacterales 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_145970_1 870187.Thini_0187 4.84e-70 216.0 COG2878@1|root,COG2878@2|Bacteria,1RE44@1224|Proteobacteria,1S5MU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_145970_2 62928.azo0517 4.82e-06 47.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,2VKQN@28216|Betaproteobacteria,2KW8X@206389|Rhodocyclales 206389|Rhodocyclales C Part of a membrane complex involved in electron transport - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_178445_1 933262.AXAM01000030_gene800 9.39e-103 315.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2MIHP@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Pyridoxal-dependent decarboxylase - - 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - - EF-hand_7,Pyridoxal_deC k59_133111_1 67373.JOBF01000029_gene5468 7.78e-09 56.2 COG1643@1|root,COG1643@2|Bacteria,2GMAW@201174|Actinobacteria 201174|Actinobacteria L ATP-dependent helicase HrpB hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_133111_2 269796.Rru_A3353 3.08e-31 113.0 COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,2UBXR@28211|Alphaproteobacteria,2JTWI@204441|Rhodospirillales 204441|Rhodospirillales P Small Multidrug Resistance protein - - - ko:K03297 - - - - ko00000,ko02000 2.A.7.1 - - Multi_Drug_Res k59_113363_3 1219072.VHA01S_017_00110 8.03e-40 150.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1XWE9@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_68158_1 290315.Clim_1081 1.06e-35 133.0 COG0368@1|root,COG0368@2|Bacteria,1FEAK@1090|Chlorobi 1090|Chlorobi H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_106922_1 1532558.JL39_18050 2.23e-06 55.5 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,4BCTT@82115|Rhizobiaceae 28211|Alphaproteobacteria S Pyrroloquinoline quinone biosynthesis protein E pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,PqqD,Radical_SAM,SPASM k59_100071_1 589865.DaAHT2_0115 1.23e-56 186.0 COG3016@1|root,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WMNG@28221|Deltaproteobacteria,2MPW9@213118|Desulfobacterales 28221|Deltaproteobacteria S Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg k59_87404_4 399739.Pmen_3960 2.47e-37 155.0 2EBVZ@1|root,335VC@2|Bacteria,1RHVC@1224|Proteobacteria,1SND1@1236|Gammaproteobacteria,1YD8D@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_87404_7 1049564.TevJSym_ae00200 8.63e-100 335.0 COG1511@1|root,COG5281@1|root,COG1511@2|Bacteria,COG5281@2|Bacteria,1MX2R@1224|Proteobacteria,1S3MM@1236|Gammaproteobacteria,1JBHH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D tape measure protein Z012_10445 - - - - - - - - - - - Phage_HK97_TLTM,Tape_meas_lam_C k59_87404_9 666685.R2APBS1_2853 2.6e-21 91.7 2E9S7@1|root,333YC@2|Bacteria,1NFVY@1224|Proteobacteria,1SH2V@1236|Gammaproteobacteria,1X90Y@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_87404_11 1223521.BBJX01000010_gene112 2.26e-14 78.2 2DBUA@1|root,2ZB4Z@2|Bacteria,1PB9S@1224|Proteobacteria,2VM25@28216|Betaproteobacteria,4AD6A@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_152295_1 349521.HCH_02209 8.3e-71 224.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1XI1W@135619|Oceanospirillales 135619|Oceanospirillales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 k59_139001_1 177437.HRM2_02960 1.25e-18 85.9 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MKDX@213118|Desulfobacterales 28221|Deltaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_127192_1 1049564.TevJSym_ak00800 1.13e-55 175.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1J6HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_127192_2 1049564.TevJSym_ak00790 1.9e-12 64.7 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1J6GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698 - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_15771_2 318161.Sden_1799 1.54e-45 155.0 COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,1S3UT@1236|Gammaproteobacteria,2QBVT@267890|Shewanellaceae 1236|Gammaproteobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - Flavodoxin_2,UbiA k59_15771_3 1238450.VIBNISOn1_1900010 2.89e-44 147.0 COG0789@1|root,COG0789@2|Bacteria,1N9D2@1224|Proteobacteria,1SBR8@1236|Gammaproteobacteria,1XYA6@135623|Vibrionales 135623|Vibrionales K Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - MerR_1 k59_197422_1 1131553.JIBI01000018_gene516 3.68e-64 234.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_16,TonB_dep_Rec k59_107092_2 765913.ThidrDRAFT_2270 1.76e-101 312.0 COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,1T1GU@1236|Gammaproteobacteria,1WY0A@135613|Chromatiales 135613|Chromatiales N Type VI secretion system protein DotU - - - ko:K11892 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - DotU,OmpA k59_113497_2 765913.ThidrDRAFT_2408 4.56e-08 53.9 COG5007@1|root,COG5007@2|Bacteria,1N1WJ@1224|Proteobacteria,1SCAR@1236|Gammaproteobacteria,1WZ0D@135613|Chromatiales 135613|Chromatiales K Belongs to the BolA IbaG family - - - - - - - - - - - - BolA k59_113497_3 1232437.KL662030_gene2451 4.59e-199 581.0 COG1234@1|root,COG1341@1|root,COG1234@2|Bacteria,COG1341@2|Bacteria,1PPRD@1224|Proteobacteria,42N8A@68525|delta/epsilon subdivisions,2WKHD@28221|Deltaproteobacteria,2MIHV@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_100239_2 1304885.AUEY01000106_gene3427 1.5e-52 182.0 COG1639@1|root,COG1639@2|Bacteria,1R8VH@1224|Proteobacteria,42ZUM@68525|delta/epsilon subdivisions,2WV54@28221|Deltaproteobacteria 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_187564_1 555778.Hneap_0798 1.29e-148 454.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WX8J@135613|Chromatiales 135613|Chromatiales EI Allophanate hydrolase subunit 1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_4755_2 1125863.JAFN01000001_gene552 4.29e-09 61.6 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_135243_1 1461582.BN1048_01567 0.000445 44.3 COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,4H9Q0@91061|Bacilli,4GYUB@90964|Staphylococcaceae 91061|Bacilli T Single cache domain 3 citS - 2.7.13.3 ko:K11614,ko:K11637 ko02020,map02020 M00487,M00490 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,PAS,PAS_9,SPOB_a,sCache_3_2 k59_129475_2 1144319.PMI16_00406 0.000146 44.7 2D1C5@1|root,32TAD@2|Bacteria,1N23F@1224|Proteobacteria,2VU98@28216|Betaproteobacteria 28216|Betaproteobacteria S Ceramidase - - - - - - - - - - - - Ceramidase k59_141447_1 1121374.KB891575_gene1604 1.4e-49 167.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux k59_70830_1 765912.Thimo_1799 5.15e-87 264.0 COG2230@1|root,COG2230@2|Bacteria,1QUR4@1224|Proteobacteria,1RP3C@1236|Gammaproteobacteria,1WX7D@135613|Chromatiales 135613|Chromatiales M Methyltransferase - - 2.1.1.157 ko:K18897 ko00260,map00260 - R10061 RC00003,RC03040 ko00000,ko00001,ko01000 - - - Methyltransf_11 k59_148181_2 1432658.V5UQP0_9CAUD 1.88e-08 55.5 4QAZF@10239|Viruses,4QUTY@35237|dsDNA viruses no RNA stage,4QPH6@28883|Caudovirales,4QM17@10699|Siphoviridae 10699|Siphoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_154446_1 1123399.AQVE01000011_gene1235 1.06e-114 358.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_148183_1 439235.Dalk_4744 5.77e-62 204.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42P7N@68525|delta/epsilon subdivisions,2WJKE@28221|Deltaproteobacteria,2MICX@213118|Desulfobacterales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_76398_1 323261.Noc_0114 3.04e-132 392.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales 135613|Chromatiales P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG k59_180597_1 768671.ThimaDRAFT_4669 2.09e-40 149.0 COG4988@1|root,COG4988@2|Bacteria,1QU1N@1224|Proteobacteria,1RNPI@1236|Gammaproteobacteria,1WWN4@135613|Chromatiales 135613|Chromatiales CO ABC transporter transmembrane region - - - ko:K16013 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran k59_180597_2 768671.ThimaDRAFT_4670 3.27e-08 54.7 COG4987@1|root,COG4987@2|Bacteria,1QU1P@1224|Proteobacteria,1RQD7@1236|Gammaproteobacteria,1WWTD@135613|Chromatiales 135613|Chromatiales CO TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC - - - ko:K16012 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran k59_50950_2 938288.HG326225_gene1071 7.78e-05 47.8 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2684B@186813|unclassified Clostridiales 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_56637_1 1249627.D779_0216 3.42e-23 95.5 COG0834@1|root,COG0834@2|Bacteria,1RHMR@1224|Proteobacteria,1TJ8R@1236|Gammaproteobacteria,1WY66@135613|Chromatiales 135613|Chromatiales ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - - - - - - - - - - - k59_141453_1 1121403.AUCV01000002_gene620 4.45e-90 291.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2MIXJ@213118|Desulfobacterales 28221|Deltaproteobacteria T Signal transducing histidine kinase, homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_83302_1 631362.Thi970DRAFT_01570 3.58e-19 80.1 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1WYHH@135613|Chromatiales 135613|Chromatiales E phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_83302_2 1249627.D779_0076 1.2e-67 207.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_83302_3 870187.Thini_2354 2.48e-06 48.1 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,45ZVN@72273|Thiotrichales 72273|Thiotrichales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_129483_1 335543.Sfum_0306 3.27e-63 208.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MQXU@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_4760_1 314285.KT71_14964 3.94e-88 283.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_89634_1 335543.Sfum_0728 6.39e-59 204.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MRDU@213462|Syntrophobacterales 28221|Deltaproteobacteria K RNB - - 3.1.13.1 ko:K01147,ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_109401_1 272560.BPSS1632 9.61e-247 777.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae 28216|Betaproteobacteria Q amino acid adenylation domain protein - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase k59_199483_2 1049564.TevJSym_at00180 1.17e-57 187.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1J5J9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the dihydroorotate dehydrogenase family pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,NAD_binding_1 k59_56649_1 1287116.X734_23570 8.25e-05 44.7 COG0526@1|root,COG0526@2|Bacteria,1QTY9@1224|Proteobacteria,2TW6Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,NHL,Redoxin,Thioredoxin_8 k59_31301_1 933262.AXAM01000054_gene2668 8.44e-122 368.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42NTQ@68525|delta/epsilon subdivisions,2WITY@28221|Deltaproteobacteria,2MIFP@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM peptidase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_102382_1 335543.Sfum_0119 2.64e-44 162.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_4767_1 1304885.AUEY01000001_gene3189 7.02e-87 267.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_89642_1 1250006.JHZZ01000001_gene705 1.1e-42 155.0 COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,1HXK2@117743|Flavobacteriia,3VW7Q@52959|Polaribacter 976|Bacteroidetes J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_180608_4 1504672.669785326 1.44e-41 138.0 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,2VXAA@28216|Betaproteobacteria 28216|Betaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_56657_2 1168034.FH5T_10125 2.13e-27 105.0 COG0494@1|root,COG0494@2|Bacteria,4NSND@976|Bacteroidetes,2G0XF@200643|Bacteroidia 976|Bacteroidetes L NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_12250_1 997296.PB1_13764 6.03e-45 169.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus 91061|Bacilli T Diguanylate cyclase gmr - - - - - - - - - - - EAL,GGDEF,PAS_8,PAS_9 k59_115546_1 1049564.TevJSym_ap00410 5.83e-68 224.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1J4NM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_115546_2 1049564.TevJSym_ap00420 2.05e-45 147.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1J6I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_4959_1 662479.C440_04448 7.96e-47 163.0 COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,23S08@183963|Halobacteria 183963|Halobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_51265_1 1125863.JAFN01000001_gene214 9.85e-107 322.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42PRI@68525|delta/epsilon subdivisions,2X5GA@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_135544_1 1049564.TevJSym_aa00270 7.63e-193 540.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1J4UB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_173704_1 1049564.TevJSym_ai00340 0.0 1257.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_180805_8 396588.Tgr7_1345 2.2e-93 283.0 COG1192@1|root,COG1192@2|Bacteria,1MWSE@1224|Proteobacteria,1RQ3X@1236|Gammaproteobacteria,1WXRP@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_180805_9 1049564.TevJSym_aw00420 1.48e-25 102.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1S294@1236|Gammaproteobacteria,1J60E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_199734_1 314345.SPV1_06144 8.71e-186 525.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria 1224|Proteobacteria E glutamine synthetase - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_187812_1 1049564.TevJSym_al00140 6.79e-25 99.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1J647@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulatory protein, C terminal lrpR - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_187812_2 1123368.AUIS01000019_gene1206 2.88e-23 103.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,2NCE0@225057|Acidithiobacillales 225057|Acidithiobacillales T His Kinase A (phospho-acceptor) domain - - 2.7.13.3 ko:K02484,ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_135549_1 589865.DaAHT2_1896 4.66e-132 387.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2MI99@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_109655_1 1232410.KI421425_gene1552 6.56e-81 268.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_115829_1 933262.AXAM01000010_gene1381 1.38e-84 268.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales 28221|Deltaproteobacteria M Penicillin-binding Protein dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_173709_3 443152.MDG893_15195 3.55e-88 270.0 COG1122@1|root,COG1122@2|Bacteria,1QN6E@1224|Proteobacteria,1S2DQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type cobalt transport system ATPase component - - - ko:K02006 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran k59_31497_1 1173028.ANKO01000250_gene2300 1.82e-155 452.0 COG1866@1|root,COG1866@2|Bacteria,1G1KI@1117|Cyanobacteria,1H944@1150|Oscillatoriales 1117|Cyanobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA - - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_64311_1 2340.JV46_18710 2.26e-44 146.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1J6QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_64311_2 1429851.X548_02985 3.98e-85 257.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1X30Z@135614|Xanthomonadales 135614|Xanthomonadales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_135560_1 1232410.KI421420_gene3185 1.75e-76 241.0 COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,439YG@68525|delta/epsilon subdivisions,2WUBB@28221|Deltaproteobacteria,43UAD@69541|Desulfuromonadales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_135560_2 525264.HMPREF0305_11742 6.2e-09 56.6 COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,22JPX@1653|Corynebacteriaceae 201174|Actinobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain regX3 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - ko:K07776 ko02020,map02020 M00443 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_76672_1 870187.Thini_2177 1.28e-57 187.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,4616Y@72273|Thiotrichales 72273|Thiotrichales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_109668_1 765912.Thimo_1819 8.01e-241 680.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_51283_1 880072.Desac_0501 2.24e-66 223.0 COG2202@1|root,COG2204@1|root,COG3290@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_56890_1 1307759.JOMJ01000003_gene1029 3e-14 76.6 COG2203@1|root,COG2203@2|Bacteria,1NI96@1224|Proteobacteria,42WWD@68525|delta/epsilon subdivisions,2WT0R@28221|Deltaproteobacteria,2M91Z@213115|Desulfovibrionales 28221|Deltaproteobacteria T GAF domain protein - - - - - - - - - - - - GAF_2 k59_102546_5 1565129.JSFF01000006_gene2468 1.53e-21 88.2 2E7CE@1|root,331VM@2|Bacteria,1N6U9@1224|Proteobacteria,1SDQ6@1236|Gammaproteobacteria,2QE2E@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_102546_6 1101195.Meth11DRAFT_0116 2.56e-42 164.0 COG4961@1|root,COG4961@2|Bacteria,1QVT9@1224|Proteobacteria,2WGTV@28216|Betaproteobacteria 28216|Betaproteobacteria U PFAM TadE family protein - - - - - - - - - - - - Tad k59_76677_1 640081.Dsui_3351 2.57e-81 256.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VMKA@28216|Betaproteobacteria,2KW8I@206389|Rhodocyclales 206389|Rhodocyclales C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_141681_2 396588.Tgr7_0575 8.97e-44 155.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1WX7Y@135613|Chromatiales 135613|Chromatiales HJ Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - - - - - - - - - - ATP-grasp_3,RLAN,RimK k59_115846_1 1121405.dsmv_2749 2.82e-73 244.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MIPG@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_83507_1 203122.Sde_2049 0.0 4746.0 COG5184@1|root,COG5276@1|root,COG5644@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,COG5644@2|Bacteria,1QX03@1224|Proteobacteria,1T31Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - RCC1_2 k59_115847_1 671143.DAMO_3063 3.3e-54 180.0 COG0746@1|root,COG0746@2|Bacteria 2|Bacteria H molybdenum cofactor guanylyltransferase activity mobA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77 ko:K03752,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_89889_1 631362.Thi970DRAFT_01994 9.65e-106 312.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_4984_2 335543.Sfum_0650 0.000618 42.0 COG0589@1|root,COG0589@2|Bacteria,1REA3@1224|Proteobacteria,42RXY@68525|delta/epsilon subdivisions,2WNM6@28221|Deltaproteobacteria,2MSDJ@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_161443_1 443143.GM18_3565 1.27e-37 139.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_46657_1 1342299.Z947_4090 4.82e-05 52.0 2DMJQ@1|root,32S16@2|Bacteria,1N4SH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_46657_2 765698.Mesci_6374 1.13e-16 87.8 COG1475@1|root,COG1475@2|Bacteria,1QYN0@1224|Proteobacteria,2VFBW@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Domain of unknown function (DUF4150) - - - - - - - - - - - - DUF4150 k59_46657_3 399739.Pmen_2335 5.69e-57 196.0 COG0304@1|root,COG0304@2|Bacteria,1R618@1224|Proteobacteria,1S1M0@1236|Gammaproteobacteria,1YIZ4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M synthase - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_131155_1 1499967.BAYZ01000069_gene1888 1.1e-91 281.0 COG0442@1|root,COG0442@2|Bacteria,2NNKF@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_118149_1 1049564.TevJSym_as00320 4.5e-88 266.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function Z012_09445 - - - - - - - - - - - Peptidase_M48 k59_7842_2 1049564.TevJSym_au00660 1e-46 158.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1J545@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1145_1 1049564.TevJSym_ao00510 6.35e-11 61.6 COG2143@1|root,COG2143@2|Bacteria,1R72D@1224|Proteobacteria,1RSDK@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_1145_3 1049564.TevJSym_ao00490 2.26e-74 236.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1SZ82@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function, DUF484 - - - - - - - - - - - - DUF484,GGDEF k59_183006_1 388051.AUFE01000016_gene5821 3.64e-125 368.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,1K52N@119060|Burkholderiaceae 28216|Betaproteobacteria S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_170046_1 550540.Fbal_2237 1.38e-11 68.9 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_27317_1 998674.ATTE01000001_gene811 5.46e-62 204.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,45ZTS@72273|Thiotrichales 72273|Thiotrichales T PFAM response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_59706_1 1184267.A11Q_372 2.01e-08 64.3 COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,430P8@68525|delta/epsilon subdivisions,2MU25@213481|Bdellovibrionales,2WVWR@28221|Deltaproteobacteria 213481|Bdellovibrionales M Belongs to the ompA family - - - - - - - - - - - - OmpA k59_66064_1 1121405.dsmv_0507 2.93e-78 248.0 COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42YHK@68525|delta/epsilon subdivisions,2WUDF@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_85585_2 1047013.AQSP01000132_gene1749 3e-24 100.0 COG0123@1|root,COG0123@2|Bacteria,2NPPE@2323|unclassified Bacteria 2|Bacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_118155_1 221988.MS0711 4.45e-39 137.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1Y761@135625|Pasteurellales 135625|Pasteurellales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_118155_2 1049564.TevJSym_be00100 1.59e-43 146.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1J5QQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_14075_1 1049564.TevJSym_ap00680 9.25e-292 809.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_137318_1 1049564.TevJSym_ag00950 1.29e-89 272.0 COG1092@1|root,COG1092@2|Bacteria,1QW1V@1224|Proteobacteria,1T4CI@1236|Gammaproteobacteria,1JC2Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J S-adenosylmethionine-dependent methyltransferase rlmL - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_176339_3 1120963.KB894521_gene5 4.14e-24 104.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,2Q12A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS,RHS_repeat k59_156900_1 62928.azo3758 3.25e-52 170.0 COG2703@1|root,COG2703@2|Bacteria,1RI40@1224|Proteobacteria,2VVCK@28216|Betaproteobacteria,2KYU8@206389|Rhodocyclales 206389|Rhodocyclales P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_189451_1 1123507.ATVQ01000003_gene506 0.000219 45.1 COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,1WCIQ@1268|Micrococcaceae 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_189451_3 1089551.KE386572_gene3138 4.3e-170 485.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,4BQ5Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L 6-O-methylguanine DNA methyltransferase, DNA binding domain ada - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N k59_189451_4 1049564.TevJSym_az00110 2.65e-60 192.0 2A08H@1|root,30NBS@2|Bacteria,1RDGP@1224|Proteobacteria,1S4RA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S [NiFe]-hydrogenase assembly, chaperone, HybE - - - - - - - - - - - - NiFe-hyd_HybE k59_189451_5 572477.Alvin_1320 5.36e-44 152.0 COG3381@1|root,COG3381@2|Bacteria,1N1T1@1224|Proteobacteria,1S9X5@1236|Gammaproteobacteria,1WZAE@135613|Chromatiales 135613|Chromatiales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_85625_4 56780.SYN_00706 1.96e-152 434.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMIV@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_27366_1 243090.RB3466 3.43e-54 192.0 COG0187@1|root,COG0187@2|Bacteria,2IWXP@203682|Planctomycetes 203682|Planctomycetes L COG0187 Type IIA topoisomerase (DNA gyrase topo II topoisomerase IV) B subunit - - 5.99.1.3 ko:K02470,ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_105020_1 335543.Sfum_0920 1.89e-71 226.0 COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales 28221|Deltaproteobacteria KQ Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_53172_1 1304284.L21TH_2298 3.1e-13 70.5 COG1762@1|root,COG1762@2|Bacteria,1VA2N@1239|Firmicutes,25BW3@186801|Clostridia 186801|Clostridia G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - 2.7.1.202 ko:K02768 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 k59_33867_2 1123060.JONP01000001_gene1496 9.09e-10 62.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria,2JSS2@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_170131_1 981223.AIED01000028_gene391 1.41e-33 122.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,3NIUD@468|Moraxellaceae 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_170131_2 1049564.TevJSym_aw00020 0.0 1166.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1J4SD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0308 Aminopeptidase N pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 DUF3458,DUF3458_C,Peptidase_M1 k59_20864_2 883080.HMPREF9697_03471 9.34e-56 180.0 COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,3JREZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S DJ-1/PfpI family pfpI - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_170132_1 177437.HRM2_31140 2.08e-90 286.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42P6S@68525|delta/epsilon subdivisions,2WIWC@28221|Deltaproteobacteria,2MI1I@213118|Desulfobacterales 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_98434_1 768671.ThimaDRAFT_2908 3.85e-93 287.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_7914_2 205922.Pfl01_3190 6.84e-43 151.0 COG1192@1|root,COG1192@2|Bacteria,1QJU3@1224|Proteobacteria,1S832@1236|Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - - - - - - - - - - - AAA_31 k59_40416_1 1304872.JAGC01000005_gene1816 1.81e-28 118.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,42NM2@68525|delta/epsilon subdivisions,2WM1N@28221|Deltaproteobacteria,2MAQ4@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_40416_2 1121921.KB898706_gene2434 7.55e-28 103.0 COG5460@1|root,COG5460@2|Bacteria,1N7MS@1224|Proteobacteria,1SCTR@1236|Gammaproteobacteria,2PP05@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Uncharacterized conserved protein (DUF2164) - - - - - - - - - - - - DUF2164 k59_111663_1 1049564.TevJSym_ax00260 3.75e-98 292.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria 1236|Gammaproteobacteria K crp fnr family - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_111663_2 1211115.ALIQ01000028_gene735 6.09e-15 69.3 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_1208_1 595536.ADVE02000001_gene1888 8.25e-48 162.0 COG0607@1|root,COG0607@2|Bacteria,1MZG3@1224|Proteobacteria,2U1W0@28211|Alphaproteobacteria,37012@31993|Methylocystaceae 28211|Alphaproteobacteria P Rhodanese-like domain - - - - - - - - - - - - Rhodanese k59_20870_1 1249627.D779_4053 5.57e-97 288.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales 135613|Chromatiales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_131234_1 449447.MAE_62270 5.98e-96 285.0 COG3335@1|root,COG3335@2|Bacteria,1G45T@1117|Cyanobacteria 1117|Cyanobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_150647_1 404589.Anae109_2580 1.88e-40 147.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_124679_1 56780.SYN_00099 3.29e-54 188.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions,2X706@28221|Deltaproteobacteria,2MQZA@213462|Syntrophobacterales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg,sCache_2 k59_189519_1 472759.Nhal_0372 7.34e-143 412.0 COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,1RZ5M@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_144217_1 1121396.KB893012_gene4043 7.11e-40 141.0 COG0247@1|root,COG0247@2|Bacteria,1R5M5@1224|Proteobacteria,42PZ1@68525|delta/epsilon subdivisions,2WKPD@28221|Deltaproteobacteria,2MKRT@213118|Desulfobacterales 28221|Deltaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG k59_144217_2 596151.DesfrDRAFT_1893 2.24e-54 171.0 COG1150@1|root,COG1150@2|Bacteria,1N6JZ@1224|Proteobacteria,42U3K@68525|delta/epsilon subdivisions,2WQQG@28221|Deltaproteobacteria,2MFCY@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_8 k59_163470_1 1121403.AUCV01000013_gene3927 4.46e-91 294.0 COG0745@1|root,COG3829@1|root,COG4251@1|root,COG0745@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42YSF@68525|delta/epsilon subdivisions,2WU0Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,Response_reg k59_163470_2 335543.Sfum_1664 1.34e-100 297.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42RQX@68525|delta/epsilon subdivisions,2WNM1@28221|Deltaproteobacteria 28221|Deltaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg k59_46754_1 323261.Noc_0335 1.14e-60 209.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXR1@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,dCache_3 k59_111673_1 1124991.MU9_2905 3e-63 209.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,1RY0J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_118259_1 1528106.JRJE01000004_gene711 2.47e-12 68.6 2CU57@1|root,32SUP@2|Bacteria,1N68C@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_118259_2 1123366.TH3_10931 3.35e-35 121.0 2BI4W@1|root,3323T@2|Bacteria,1N96Z@1224|Proteobacteria,2UHQI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Killing trait - - - - - - - - - - - - RebB k59_118259_3 454957.IA64_05185 3.27e-28 105.0 2BI4W@1|root,32CA3@2|Bacteria,1RHWB@1224|Proteobacteria,1SFDY@1236|Gammaproteobacteria,1XAK5@135614|Xanthomonadales 135614|Xanthomonadales S Killing trait rebB - - - - - - - - - - - RebB k59_1214_1 1049564.TevJSym_ah00590 6.5e-120 348.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1J5PC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine xapA GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006148,GO:0006149,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008617,GO:0009056,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009987,GO:0015949,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0022607,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0042454,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046094,GO:0046102,GO:0046115,GO:0046121,GO:0046122,GO:0046124,GO:0046128,GO:0046130,GO:0046483,GO:0046700,GO:0047724,GO:0047975,GO:0051259,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072521,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658,GO:1903227,GO:1903228 2.4.2.1,2.4.2.28,2.4.2.44 ko:K00772,ko:K03783,ko:K03815,ko:K19696 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R09668,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1171,iUMN146_1321.UM146_04590,iUTI89_1310.UTI89_C2739 PNP_UDP_1 k59_1214_2 768671.ThimaDRAFT_3950 1.94e-05 45.8 COG3945@1|root,COG3945@2|Bacteria,1RBVC@1224|Proteobacteria,1S2ZK@1236|Gammaproteobacteria,1WY19@135613|Chromatiales 135613|Chromatiales S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_53192_1 420247.Msm_1242 1.1e-51 178.0 COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,23PBY@183925|Methanobacteria 183925|Methanobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine - - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_150656_1 933262.AXAM01000048_gene2601 3.72e-54 189.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_131246_1 930169.B5T_04349 1.9e-35 120.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1XM7A@135619|Oceanospirillales 135619|Oceanospirillales C rubredoxin rubA - - - - - - - - - - - Rubredoxin k59_131246_2 998674.ATTE01000001_gene4510 2.21e-37 136.0 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,461U3@72273|Thiotrichales 72273|Thiotrichales V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane k59_59802_1 435908.IDSA_11890 1.07e-80 268.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,2QFKS@267893|Idiomarinaceae 1236|Gammaproteobacteria M POTRA domain TamA domain 1 tamA - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_144223_1 1049564.TevJSym_ab01910 3.67e-197 562.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ygaD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_27386_1 696747.NIES39_K05060 0.000175 50.4 COG0747@1|root,COG0747@2|Bacteria,1G1K6@1117|Cyanobacteria,1H7HS@1150|Oscillatoriales 1117|Cyanobacteria E ABC-type dipeptide transport system periplasmic component ddpA - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_72651_1 1049564.TevJSym_bb00130 4.68e-97 309.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_72651_2 1049564.TevJSym_bb00120 6.32e-61 195.0 COG2413@1|root,COG2413@2|Bacteria,1RFTH@1224|Proteobacteria,1T4QX@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_72651_3 1380394.JADL01000005_gene5521 8.03e-15 73.6 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2JPW2@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_189526_1 391625.PPSIR1_14610 5.38e-13 76.3 COG3220@1|root,COG3220@2|Bacteria,1RH40@1224|Proteobacteria,4323W@68525|delta/epsilon subdivisions,2WXC6@28221|Deltaproteobacteria,2YUXY@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_189526_2 870187.Thini_0262 2.62e-47 158.0 COG1309@1|root,COG1309@2|Bacteria,1RG05@1224|Proteobacteria,1S7XG@1236|Gammaproteobacteria,461E2@72273|Thiotrichales 72273|Thiotrichales K Transcriptional regulator - - - - - - - - - - - - TetR_C_10,TetR_N k59_20886_1 1453501.JELR01000002_gene342 1.18e-74 258.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_46758_1 879212.DespoDRAFT_02520 6.39e-173 498.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - - - - - - - - - - - GIIM,RVT_1 k59_40440_1 1235279.C772_01024 1.37e-73 234.0 COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HBMX@91061|Bacilli,26DKF@186818|Planococcaceae 91061|Bacilli H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_197164_1 1125863.JAFN01000001_gene1100 6.29e-30 116.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria 1224|Proteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_197164_2 987059.RBXJA2T_05278 4.12e-08 53.5 COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,1KM2Q@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_171779_1 1123253.AUBD01000010_gene2207 1.13e-22 95.5 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1X51Z@135614|Xanthomonadales 135614|Xanthomonadales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_145846_1 246197.MXAN_3204 3.92e-34 135.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2YUFJ@29|Myxococcales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_165048_1 945713.IALB_2868 2.53e-43 156.0 COG2986@1|root,COG2986@2|Bacteria 2|Bacteria E ammonia-lyase activity hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_9713_1 75379.Tint_1392 5.06e-63 221.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_54716_1 644282.Deba_1011 1.13e-75 234.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NI5@68525|delta/epsilon subdivisions,2WIN8@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_197168_1 1049564.TevJSym_be00050 4.84e-83 254.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,1RP94@1236|Gammaproteobacteria 1236|Gammaproteobacteria S radical SAM protein yhcC GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_158716_2 1122194.AUHU01000008_gene3282 1e-45 170.0 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,464DD@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_126857_1 439235.Dalk_0774 8.07e-50 175.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2MIHC@213118|Desulfobacterales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_99976_1 903818.KI912268_gene1559 1.05e-46 161.0 COG0476@1|root,COG0476@2|Bacteria 2|Bacteria H Involved in molybdopterin and thiamine biosynthesis, family 2 moeB - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_48509_1 717231.Flexsi_1233 8.79e-43 155.0 COG4664@1|root,COG4664@2|Bacteria,2GF7X@200930|Deferribacteres 200930|Deferribacteres Q PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_152199_1 1336235.JAEG01000002_gene303 4.34e-22 102.0 COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2UQ5D@28211|Alphaproteobacteria,4BNFZ@82115|Rhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_152199_2 298386.PBPRB0014 0.0 931.0 COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1XW5B@135623|Vibrionales 135623|Vibrionales IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_152199_5 648757.Rvan_1393 2.93e-14 72.4 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,3N675@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_28955_2 511062.GU3_09380 2.63e-54 172.0 2C092@1|root,310YA@2|Bacteria,1PP05@1224|Proteobacteria,1TCG8@1236|Gammaproteobacteria,1Y6C4@135624|Aeromonadales 135624|Aeromonadales - - - - - - - - - - - - - - - k59_28955_3 1178482.BJB45_12345 2.67e-296 823.0 COG3843@1|root,COG3843@2|Bacteria,1QUDG@1224|Proteobacteria,1RSQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase k59_106831_2 331869.BAL199_15167 1.37e-84 256.0 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria,4BRXP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_185253_1 643562.Daes_3095 1.21e-53 181.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_22962_1 114615.BRADO2378 1.5e-99 299.0 COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2TVHU@28211|Alphaproteobacteria,3JTGW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family MA20_10350 - - - - - - - - - - - HTH_1,LysR_substrate k59_22962_2 702113.PP1Y_Mpl5228 1.33e-169 490.0 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,2K261@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator - - - - - - - - - - - - MFS_1,MFS_4,TRI12 k59_87608_1 420324.KI911965_gene416 5.21e-114 342.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,1JUMW@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Recombinase zinc beta ribbon domain - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_9990_1 933262.AXAM01000011_gene1755 3.93e-73 239.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,2MJ25@213118|Desulfobacterales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_9,Pyr_redox_2 k59_146126_1 335543.Sfum_4069 1.36e-73 234.0 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_48801_1 448385.sce2098 2.15e-43 166.0 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42Q9W@68525|delta/epsilon subdivisions,2X2J4@28221|Deltaproteobacteria,2YYBY@29|Myxococcales 28221|Deltaproteobacteria S homolog of phage Mu protein gp47 - - - - - - - - - - - - - k59_87610_1 1123371.ATXH01000002_gene290 8.7e-21 95.5 COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,2GHUJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.132 ko:K00595 ko00860,ko01100,map00860,map01100 - R05149 RC00003,RC01279 ko00000,ko00001,ko01000 - - - Methyltransf_4,TP_methylase k59_113534_1 156889.Mmc1_1203 8.65e-34 125.0 28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,2TUCS@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Dinitrogenase reductase ADP-ribosyltransferase (DRAT) draT - 2.4.2.37 ko:K05951 - - - - ko00000,ko01000 - - - DRAT k59_152412_1 1280941.HY2_16805 3.54e-23 95.5 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_152412_2 314225.ELI_14895 3.89e-40 134.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2K5CA@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_81383_1 1031711.RSPO_c03178 9.55e-244 686.0 COG4650@1|root,COG4650@2|Bacteria,1MX6U@1224|Proteobacteria,2VHTV@28216|Betaproteobacteria,1K578@119060|Burkholderiaceae 28216|Betaproteobacteria K Regulator of RNA terminal phosphate cyclase rtcR - - ko:K14414 - - - - ko00000,ko03000 - - - RtcR,Sigma54_activat k59_81383_3 1049564.TevJSym_ah00890 1.2e-80 243.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1J5QA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB - - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_197433_1 1049564.TevJSym_aj00010 1.29e-81 274.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,1S157@1236|Gammaproteobacteria,1JA89@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_139201_2 706587.Desti_1263 1.06e-44 157.0 COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2MQDR@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Nucleotidyl transferase manAC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_113535_1 644801.Psest_3025 1.02e-103 315.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1Z0AN@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Cytochrome bd-type quinol oxidase, subunit 1 cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iPC815.YPO1117,iSFxv_1172.SFxv_0621,iS_1188.S0577 Cyt_bd_oxida_I k59_191422_1 449447.MAE_21180 8.81e-54 179.0 COG1834@1|root,COG1834@2|Bacteria,1G48J@1117|Cyanobacteria 1117|Cyanobacteria E amidinotransferase - - 2.1.4.1 ko:K00613 ko00260,ko00330,ko01100,map00260,map00330,map01100 M00047 R00565,R01989 RC00024,RC02749 ko00000,ko00001,ko00002,ko01000 - - - Amidinotransf k59_191422_2 448385.sce7577 2.18e-103 318.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2Z2YT@29|Myxococcales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_100294_1 857087.Metme_1262 9.1e-21 100.0 COG1475@1|root,COG3209@1|root,COG1475@2|Bacteria,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XE8X@135618|Methylococcales 135618|Methylococcales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_22967_1 105559.Nwat_2332 4.28e-66 220.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WX1S@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_107145_1 1049564.TevJSym_aw00250 2.2e-82 251.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_107145_2 292415.Tbd_2480 3.25e-10 58.5 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,2VSFJ@28216|Betaproteobacteria,1KT3U@119069|Hydrogenophilales 119069|Hydrogenophilales P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_9999_1 296591.Bpro_0131 1.23e-67 219.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,2VJJ3@28216|Betaproteobacteria,4AAA4@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_185264_1 706587.Desti_4262 1.14e-15 77.8 COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 k59_185264_2 335543.Sfum_1175 6.7e-19 78.2 COG1908@1|root,COG1908@2|Bacteria,1NM99@1224|Proteobacteria,42X5B@68525|delta/epsilon subdivisions,2WTHK@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_139203_2 1049564.TevJSym_as00630 2.83e-55 177.0 COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,1S75J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family, UPF0114 - - - - - - - - - - - - UPF0114 k59_29222_1 933262.AXAM01000050_gene3492 2.07e-68 223.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,2MHRK@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM peptidase - - - - - - - - - - - iAF987.Gmet_1238 Peptidase_M48,TPR_14,TPR_16,TPR_19 k59_165262_1 765911.Thivi_2743 1.78e-26 109.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_165262_2 1121374.KB891575_gene1110 7.1e-10 62.8 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - DUF4214,HYR k59_165262_4 1049564.TevJSym_bh00070 1.14e-86 271.0 COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,1RZ5C@1236|Gammaproteobacteria,1J641@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_165262_6 377629.TERTU_3450 4.04e-52 206.0 COG2885@1|root,COG4547@1|root,COG5384@1|root,COG5644@1|root,COG2885@2|Bacteria,COG4547@2|Bacteria,COG5384@2|Bacteria,COG5644@2|Bacteria,1MX1F@1224|Proteobacteria,1RYU1@1236|Gammaproteobacteria,2PNMF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria HJM Cadherin repeats. - - - - - - - - - - - - Cadherin_3,DUF4347,OmpA k59_165262_8 1278307.KB906973_gene1352 3.32e-45 161.0 COG3307@1|root,COG3307@2|Bacteria,1QR23@1224|Proteobacteria,1SMCP@1236|Gammaproteobacteria,2QHRI@267894|Psychromonadaceae 1236|Gammaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_68361_1 357804.Ping_1941 1.2e-100 300.0 COG0569@1|root,COG0569@2|Bacteria,1QZBR@1224|Proteobacteria,1T44X@1236|Gammaproteobacteria,2QIHV@267894|Psychromonadaceae 1236|Gammaproteobacteria P Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_185270_1 1121405.dsmv_3388 5.34e-89 280.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MHVX@213118|Desulfobacterales 28221|Deltaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_127255_1 331678.Cphamn1_2450 7.23e-64 207.0 COG3039@1|root,COG3039@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_146133_1 29306.JOBE01000032_gene5861 8.82e-19 90.9 2F8P4@1|root,3411J@2|Bacteria,2IBX6@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_146133_2 640081.Dsui_1851 6e-50 180.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1N17V@1224|Proteobacteria,2WEJE@28216|Betaproteobacteria,2KUR7@206389|Rhodocyclales 206389|Rhodocyclales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_191432_2 759362.KVU_1687 8.7e-06 53.1 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2TRUP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S virion core protein (lumpy skin disease virus) ydjI - - - - - - - - - - - Band_7_1,DUF4339,SHOCT k59_48814_1 379066.GAU_3726 1.32e-38 143.0 COG3666@1|root,COG3666@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_159014_1 234267.Acid_5317 2.92e-32 129.0 COG1640@1|root,COG1640@2|Bacteria,3Y6TQ@57723|Acidobacteria 57723|Acidobacteria G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_94860_1 1499967.BAYZ01000159_gene536 5.19e-120 348.0 COG3384@1|root,COG3384@2|Bacteria 2|Bacteria S 3-carboxyethylcatechol 2,3-dioxygenase activity - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA,LigB k59_43000_1 95619.PM1_0206570 1.14e-76 234.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271,ko:K12961 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005,ko03036 - - - SIS_2 k59_87627_1 1232410.KI421421_gene3668 2.47e-44 162.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,43S0M@69541|Desulfuromonadales 28221|Deltaproteobacteria F Transketolase, thiamine diphosphate binding domain dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_87627_2 309803.CTN_1159 1.73e-07 52.0 COG1189@1|root,COG1189@2|Bacteria,2GCVS@200918|Thermotogae 200918|Thermotogae J ribosomal RNA methyltransferase RrmJ FtsJ - - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_139216_1 1499967.BAYZ01000004_gene4928 5.07e-50 176.0 COG2201@1|root,COG2201@2|Bacteria,2NNUY@2323|unclassified Bacteria 2|Bacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,Response_reg k59_197444_1 745411.B3C1_05872 3.17e-68 234.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1J4NA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway component ExeA - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_22986_1 1121403.AUCV01000054_gene2598 1.26e-87 261.0 COG2220@1|root,COG2220@2|Bacteria,1PFZZ@1224|Proteobacteria,42SXY@68525|delta/epsilon subdivisions,2WPFM@28221|Deltaproteobacteria,2MMG4@213118|Desulfobacterales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_48818_1 713586.KB900536_gene2498 2.62e-149 426.0 COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,1RYY5@1236|Gammaproteobacteria,1WW1F@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_54943_1 756883.Halar_0386 3.1e-16 91.7 COG0553@1|root,arCOG07871@1|root,arCOG00871@2157|Archaea,arCOG07871@2157|Archaea 2157|Archaea L COG1061 DNA or RNA helicases of superfamily II - - - - - - - - - - - - Helicase_C,PLDc_2,SNF2_N k59_25845_19 679897.HMU12120 2.86e-13 80.9 COG1674@1|root,COG1674@2|Bacteria,1QKMD@1224|Proteobacteria,42YK4@68525|delta/epsilon subdivisions 1224|Proteobacteria D FtsK/SpoIIIE family - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - DndE,FtsK_SpoIIIE k59_25845_21 857293.CAAU_0904 6.01e-16 83.2 COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,247TB@186801|Clostridia,36EZ3@31979|Clostridiaceae 186801|Clostridia L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_206778_1 1110697.NCAST_05_02650 5.9e-56 200.0 COG0457@1|root,COG0457@2|Bacteria,2GSU3@201174|Actinobacteria 201174|Actinobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_206778_2 159087.Daro_3619 7.41e-84 254.0 COG3108@1|root,COG3108@2|Bacteria 2|Bacteria S Peptidase M15 - - - ko:K03791 - - - - ko00000 - GH19 - Peptidase_M15_3 k59_206778_3 159087.Daro_3618 0.0 1849.0 COG0457@1|root,COG1075@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1075@2|Bacteria,COG4995@2|Bacteria,1MUIQ@1224|Proteobacteria,2VKH5@28216|Betaproteobacteria,2KVCP@206389|Rhodocyclales 206389|Rhodocyclales S CHAT domain - - - - - - - - - - - - CHAT,LCAT k59_206778_5 671143.DAMO_2073 7.36e-129 374.0 COG4249@1|root,COG4249@2|Bacteria,2NQXX@2323|unclassified Bacteria 2|Bacteria S Caspase domain atmc2 - - - - - - - - - - - Peptidase_C14 k59_32147_1 1109445.AGSX01000070_gene64 1.63e-39 150.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,1Z08B@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_32147_2 1049564.TevJSym_ac00750 1.93e-21 92.8 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,1RM9B@1236|Gammaproteobacteria,1J56V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliG GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_181227_1 1304885.AUEY01000002_gene347 3.97e-109 328.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_194174_1 76114.p2B11 5.64e-09 58.9 COG3846@1|root,COG3846@2|Bacteria,1MVFD@1224|Proteobacteria,2W9G2@28216|Betaproteobacteria,2KZKM@206389|Rhodocyclales 206389|Rhodocyclales U TrbL/VirB6 plasmid conjugal transfer protein - - - ko:K07344 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - TrbL k59_194174_2 1198232.CYCME_3017 1.26e-39 136.0 2ECDJ@1|root,336BT@2|Bacteria,1NFS2@1224|Proteobacteria,1SPVG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_116304_1 1232437.KL662073_gene1725 7.78e-125 377.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_90555_1 933262.AXAM01000050_gene3478 2.77e-110 324.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2MIV5@213118|Desulfobacterales 28221|Deltaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0547 Asp_Glu_race k59_174310_1 765913.ThidrDRAFT_0585 1.82e-188 546.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQMR@1236|Gammaproteobacteria,1WZXU@135613|Chromatiales 135613|Chromatiales KQ GAF modulated sigma54 specific transcriptional regulator, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_174310_2 634177.GLX_17720 3.86e-41 160.0 COG3203@1|root,COG3203@2|Bacteria,1P7S0@1224|Proteobacteria,2U33N@28211|Alphaproteobacteria,2JXFW@204441|Rhodospirillales 204441|Rhodospirillales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - k59_194177_1 595494.Tola_2369 1.13e-45 157.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1Y3YI@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_194177_2 426114.THI_0119 3.6e-12 66.2 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,1KJFN@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_162020_1 880073.Calab_0176 1.25e-16 83.6 COG3666@1|root,COG3666@2|Bacteria,2NPCA@2323|unclassified Bacteria 2|Bacteria L COGs COG3666 Transposase and inactivated derivatives - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_194185_1 335543.Sfum_1972 5.84e-97 292.0 COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1NQN7@1224|Proteobacteria,42MGI@68525|delta/epsilon subdivisions,2WKNC@28221|Deltaproteobacteria,2MRN3@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain hdrD - - - - - - - - - - - Fer4_10,Fer4_17,Fer4_8,FlpD,FrhB_FdhB_C k59_155255_1 243233.MCA1782 1.43e-56 191.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1XDQP@135618|Methylococcales 135618|Methylococcales L ATPase, AAA - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_311_1 207954.MED92_04402 8.56e-15 73.9 COG0348@1|root,COG0348@2|Bacteria,1QTQB@1224|Proteobacteria,1RXUW@1236|Gammaproteobacteria,1XN2H@135619|Oceanospirillales 135619|Oceanospirillales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_10,Fer4_5 k59_129948_1 207559.Dde_0104 6.27e-105 315.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2M8XA@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM glutamine synthetase catalytic region glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_91062_1 1121405.dsmv_2195 6.55e-133 394.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_123462_1 177437.HRM2_10540 2.84e-37 134.0 COG1102@1|root,COG1102@2|Bacteria,1R9XZ@1224|Proteobacteria,42R78@68525|delta/epsilon subdivisions,2WN7X@28221|Deltaproteobacteria,2MJR4@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 k59_129952_1 1177181.T9A_00990 1.19e-30 113.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1XJQG@135619|Oceanospirillales 135619|Oceanospirillales E D,D-heptose 1,7-bisphosphate phosphatase gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_129952_2 1049564.TevJSym_aq00120 2.87e-50 161.0 2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - MazG k59_110485_1 404589.Anae109_0693 5.22e-76 233.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2YUWK@29|Myxococcales 28221|Deltaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_39142_3 1116472.MGMO_120c00240 1.23e-62 197.0 2AJ59@1|root,319PV@2|Bacteria,1QWKR@1224|Proteobacteria,1T37J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type VI secretion system (T6SS), amidase effector protein 4 - - - - - - - - - - - - Tae4 k59_149400_1 1049564.TevJSym_ak00700 3.74e-132 380.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1J5SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase ramA - 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_149400_2 1049564.TevJSym_ak00710 2.6e-245 683.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1J6MY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_116986_1 1123393.KB891316_gene1297 3.21e-75 229.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,1KRJT@119069|Hydrogenophilales 119069|Hydrogenophilales E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_116986_2 1049564.TevJSym_af00570 1.44e-13 69.3 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J523@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_110486_1 96561.Dole_2807 1.07e-21 98.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_162375_2 1121413.JMKT01000009_gene2035 1.81e-32 122.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria,2MBN3@213115|Desulfovibrionales 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA-2 - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_333_2 706587.Desti_2974 2.43e-18 84.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42NA7@68525|delta/epsilon subdivisions,2WIN5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_149405_1 96561.Dole_1733 3.93e-12 70.9 COG2911@1|root,COG3391@1|root,COG5276@1|root,COG2911@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria,1QW1C@1224|Proteobacteria 1224|Proteobacteria G Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566 k59_110490_1 335543.Sfum_1550 2.45e-129 403.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_58685_1 1121448.DGI_2148 4.23e-25 99.8 2DSJI@1|root,33GEP@2|Bacteria,1N39S@1224|Proteobacteria,42UW5@68525|delta/epsilon subdivisions,2WR68@28221|Deltaproteobacteria,2MC9J@213115|Desulfovibrionales 28221|Deltaproteobacteria S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD k59_175292_1 1158601.I585_00215 7.74e-36 132.0 COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,4HAJ2@91061|Bacilli,4AZ63@81852|Enterococcaceae 91061|Bacilli F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_97541_1 883126.HMPREF9710_04622 1.72e-42 154.0 COG0464@1|root,COG0464@2|Bacteria,1MXFG@1224|Proteobacteria,2WGM1@28216|Betaproteobacteria,476UP@75682|Oxalobacteraceae 28216|Betaproteobacteria O ATPases associated with a variety of cellular activities - - - - - - - - - - - - - k59_65097_2 283699.D172_2567 4.51e-12 68.6 COG3831@1|root,COG3831@2|Bacteria,1R4HW@1224|Proteobacteria,1S0Y2@1236|Gammaproteobacteria,2Q1NN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF4240) - - - - - - - - - - - - DUF4240 k59_65097_3 1267600.JFGT01000006_gene1209 2.67e-26 107.0 COG1475@1|root,COG3210@1|root,COG4582@1|root,COG1475@2|Bacteria,COG3210@2|Bacteria,COG4582@2|Bacteria,1MX2K@1224|Proteobacteria,1RNRK@1236|Gammaproteobacteria,3W09V@53335|Pantoea 1236|Gammaproteobacteria U Large exoproteins involved in heme utilization or adhesion fhaB - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,LHH,PT-VENN k59_65097_5 406817.XNC1_2878 3.12e-08 54.3 2D1NA@1|root,32TB1@2|Bacteria,1N5E7@1224|Proteobacteria,1SBK5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Toxin SymE, type I toxin-antitoxin system - - - ko:K19048 - - - - ko00000,ko02048 - - - SymE_toxin k59_65097_6 1033802.SSPSH_001862 1.7e-13 66.2 2EMFR@1|root,33F4G@2|Bacteria,1NJ55@1224|Proteobacteria,1SW6Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_65097_8 306281.AJLK01000070_gene3660 1.5e-48 161.0 COG2405@1|root,COG2405@2|Bacteria,1G5DX@1117|Cyanobacteria 1117|Cyanobacteria S nucleic acid-binding protein - - - - - - - - - - - - DUF3368 k59_65097_9 1173264.KI913949_gene4430 2.66e-25 96.7 COG2886@1|root,COG2886@2|Bacteria,1G7YG@1117|Cyanobacteria,1HCR8@1150|Oscillatoriales 1117|Cyanobacteria S Uncharacterised protein family (UPF0175) - - - - - - - - - - - - UPF0175 k59_116998_1 1121413.JMKT01000011_gene2241 1.33e-14 75.5 COG3829@1|root,COG3829@2|Bacteria,1R63H@1224|Proteobacteria,42PJI@68525|delta/epsilon subdivisions,2WK7M@28221|Deltaproteobacteria,2M8XG@213115|Desulfovibrionales 28221|Deltaproteobacteria K Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat k59_201312_1 1123372.AUIT01000007_gene501 7.24e-19 90.1 COG1193@1|root,COG1193@2|Bacteria,2GH4R@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_39164_2 933262.AXAM01000094_gene2190 2.41e-94 280.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein dsrO - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 k59_6816_2 1049564.TevJSym_aj00150 3.92e-44 147.0 2DSPU@1|root,33GZC@2|Bacteria,1NJ5W@1224|Proteobacteria,1SHAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - PilZ k59_103979_1 1049564.TevJSym_au00070 3.48e-47 162.0 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,1S133@1236|Gammaproteobacteria,1JAAK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_103979_2 1121935.AQXX01000098_gene1664 2.13e-107 325.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XNPS@135619|Oceanospirillales 135619|Oceanospirillales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_129957_1 208444.JNYY01000002_gene1617 1.92e-15 74.7 2D1C5@1|root,32TAD@2|Bacteria,2IR5T@201174|Actinobacteria,4E5IX@85010|Pseudonocardiales 201174|Actinobacteria S Ceramidase - - - - - - - - - - - - Ceramidase k59_129957_2 396588.Tgr7_1428 9.34e-32 115.0 2EC4Z@1|root,3363S@2|Bacteria,1N9YG@1224|Proteobacteria,1SSSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_149422_1 1049564.TevJSym_ap00660 9.7e-237 661.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3206 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_149422_2 2340.JV46_03700 8.1e-108 320.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1J4XT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_45644_1 765910.MARPU_14060 2.19e-14 72.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WVW1@135613|Chromatiales 135613|Chromatiales C 4Fe-4S ferredoxin iron-sulfur binding domain protein glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_45644_2 323261.Noc_0844 9.86e-132 387.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1WX7V@135613|Chromatiales 135613|Chromatiales C PFAM FAD linked oxidase domain protein glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_45644_3 768671.ThimaDRAFT_0605 9.83e-161 466.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_6826_2 1049564.TevJSym_ab01870 1.79e-132 389.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_6826_3 1049564.TevJSym_ab01860 5.68e-41 146.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1J4YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_19742_1 1049564.TevJSym_bh00130 3.5e-94 281.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_19742_2 1408445.JHXP01000005_gene216 7.49e-08 53.1 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1JC4U@118969|Legionellales 118969|Legionellales S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_84570_1 880072.Desac_1949 6e-64 220.0 COG2197@1|root,COG2203@1|root,COG4191@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRI2@213462|Syntrophobacterales 28221|Deltaproteobacteria T Signal transduction response regulator, receiver domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1,sCache_2 k59_129973_1 1030157.AFMP01000028_gene2249 1.29e-33 132.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,2K18J@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_188291_1 472759.Nhal_2864 1.73e-61 199.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_13262_1 1046714.AMRX01000001_gene1246 1.64e-71 257.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,466MR@72275|Alteromonadaceae 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_188298_1 1192759.AKIB01000017_gene1786 1.89e-05 45.8 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K9SN@204457|Sphingomonadales 204457|Sphingomonadales C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_188298_2 566466.NOR53_1227 5.06e-37 138.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J84T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C COG1012 NAD-dependent aldehyde dehydrogenases - - - - - - - - - - - - Aldedh k59_136454_1 266117.Rxyl_0327 4.01e-27 110.0 COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4CPFU@84995|Rubrobacteria 84995|Rubrobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_136454_2 83406.HDN1F_30290 8.69e-21 95.1 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_105915_1 999425.HMPREF9186_02045 5.58e-47 179.0 COG5283@1|root,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HEHJ@91061|Bacilli 91061|Bacilli D Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail k59_105915_4 643562.Daes_2396 9.25e-57 193.0 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,42YRB@68525|delta/epsilon subdivisions,2WTP7@28221|Deltaproteobacteria,2MAFC@213115|Desulfovibrionales 28221|Deltaproteobacteria S Tail sheath - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k59_164261_2 871968.DESME_12525 2.72e-13 71.6 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,260DU@186807|Peptococcaceae 186801|Clostridia F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_22021_1 864069.MicloDRAFT_00004650 2.67e-79 246.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,1JZ15@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_8860_1 1304275.C41B8_11653 7.09e-69 233.0 COG1562@1|root,COG1657@1|root,COG1562@2|Bacteria,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria 1236|Gammaproteobacteria I PFAM Prenyltransferase squalene oxidase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_60674_1 203122.Sde_2049 0.0 1232.0 COG5184@1|root,COG5276@1|root,COG5644@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,COG5644@2|Bacteria,1QX03@1224|Proteobacteria,1T31Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - RCC1_2 k59_203288_1 933262.AXAM01000013_gene1320 1.15e-50 171.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2MJFR@213118|Desulfobacterales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N k59_41557_1 216596.RL4151 2.96e-197 561.0 COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,4BAW0@82115|Rhizobiaceae 28211|Alphaproteobacteria L High confidence in function and specificity - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_145110_1 1049564.TevJSym_aj00370 1.02e-30 110.0 COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1J760@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_145110_2 472759.Nhal_0484 1.38e-130 393.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_80314_1 56780.SYN_01628 3.07e-91 280.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales 28221|Deltaproteobacteria E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_86605_1 768671.ThimaDRAFT_4734 6.24e-83 260.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1WW9T@135613|Chromatiales 135613|Chromatiales P PFAM Citrate transporter - - - - - - - - - - - - CitMHS k59_138168_1 1297569.MESS2_80061 3.13e-06 54.3 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_99251_1 1249627.D779_0930 1.67e-154 439.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales 135613|Chromatiales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_119317_2 1229172.JQFA01000004_gene760 4.05e-89 278.0 COG1194@1|root,COG1194@2|Bacteria,1G7MC@1117|Cyanobacteria,1HHSR@1150|Oscillatoriales 1117|Cyanobacteria L NUDIX domain mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_80318_1 96561.Dole_1367 3.32e-111 350.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales 28221|Deltaproteobacteria KLT PFAM Protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_93405_1 1249627.D779_2921 1.11e-98 307.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_157887_1 1049564.TevJSym_ac01570 4.14e-42 141.0 COG3160@1|root,COG3160@2|Bacteria 2|Bacteria K Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_53984_1 1121441.AUCX01000021_gene686 7.24e-68 213.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,42VTP@68525|delta/epsilon subdivisions,2WRQG@28221|Deltaproteobacteria,2MAVF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Putative vitamin uptake transporter - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_22046_1 1068978.AMETH_5978 4.05e-08 58.2 2C7PT@1|root,2ZXN2@2|Bacteria,2GM64@201174|Actinobacteria,4EBI2@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_28444_2 87626.PTD2_08254 1.61e-58 185.0 2DPCE@1|root,331HP@2|Bacteria,1RGTH@1224|Proteobacteria,1S4QM@1236|Gammaproteobacteria,2Q4IQ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_15042_1 1049564.TevJSym_af00570 4.76e-139 408.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J523@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_99421_2 335543.Sfum_4041 1.47e-31 112.0 2DS67@1|root,33ER5@2|Bacteria,1R3JK@1224|Proteobacteria,43DKG@68525|delta/epsilon subdivisions,2X8RN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Dissimilatory sulfite reductase D - - - - - - - - - - - - DsrD k59_190559_1 1123401.JHYQ01000007_gene537 5.34e-128 380.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,45ZTS@72273|Thiotrichales 72273|Thiotrichales T PFAM response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_190559_2 998674.ATTE01000001_gene810 3.07e-112 330.0 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,1RZ6B@1236|Gammaproteobacteria,4622J@72273|Thiotrichales 72273|Thiotrichales H PBP superfamily domain - - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_112745_1 706587.Desti_1352 2.09e-62 204.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_112745_2 765912.Thimo_2343 2.51e-248 704.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales 135613|Chromatiales G TIGRFAM malto-oligosyltrehalose trehalohydrolase - - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_112745_3 323848.Nmul_A1402 2.85e-12 65.9 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria 28216|Betaproteobacteria G 4-alpha-glucanotransferase treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_67269_1 323259.Mhun_1334 1.24e-38 141.0 COG0725@1|root,arCOG00219@2157|Archaea,2XVTP@28890|Euryarchaeota,2NAZJ@224756|Methanomicrobia 224756|Methanomicrobia P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_119515_2 1049564.TevJSym_al00580 7.01e-39 131.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1RXCG@1236|Gammaproteobacteria,1JBB2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Rieske-like [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_35061_1 96561.Dole_0083 6.47e-101 306.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2WJ9W@28221|Deltaproteobacteria,2MHXV@213118|Desulfobacterales 28221|Deltaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_28448_1 395493.BegalDRAFT_2709 6.05e-19 83.6 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria 1224|Proteobacteria L dna polymerase III (Chi subunit) holC GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_9072_1 706587.Desti_2024 6.48e-87 283.0 COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_99426_1 439235.Dalk_3415 1.59e-76 256.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MMWB@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_41781_2 1049564.TevJSym_ac00740 3.71e-79 244.0 COG1317@1|root,COG1317@2|Bacteria,1NBN3@1224|Proteobacteria,1SWWK@1236|Gammaproteobacteria,1J6X3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar biosynthesis type III secretory pathway protein - - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH k59_60904_1 909663.KI867150_gene2871 1.73e-159 468.0 COG3039@1|root,COG3039@2|Bacteria,1QY2X@1224|Proteobacteria 1224|Proteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6 k59_164452_1 497964.CfE428DRAFT_4253 1.57e-36 140.0 COG0523@1|root,COG0523@2|Bacteria,46URF@74201|Verrucomicrobia 74201|Verrucomicrobia S SRP54-type protein, GTPase domain - - - - - - - - - - - - cobW k59_171296_1 521674.Plim_1847 2.98e-42 160.0 COG2204@1|root,COG2204@2|Bacteria,2IY6A@203682|Planctomycetes 203682|Planctomycetes T Ornithine decarboxylase inhibitor-putative sigma54 transciptional regulator - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - FHA,GAF,GAF_2,HTH_8,Sigma54_activat k59_203459_1 1117314.PCIT_20594 1.92e-36 144.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2PZEP@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_54148_1 479432.Sros_3166 4.1e-11 68.2 COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4EPXP@85012|Streptosporangiales 201174|Actinobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_106128_1 1540257.JQMW01000013_gene903 3.47e-135 399.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae 186801|Clostridia I Belongs to the thiolase family thlA2 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_106128_2 671143.DAMO_0994 8.49e-46 155.0 COG1247@1|root,COG1247@2|Bacteria 2|Bacteria M phosphinothricin N-acetyltransferase activity MA20_16670 - - - - - - - - - - - Acetyltransf_1 k59_99431_1 1249627.D779_0855 1.12e-110 352.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_60907_1 1049564.TevJSym_ac01400 1.76e-177 516.0 28N8G@1|root,2ZBCV@2|Bacteria,1NMB1@1224|Proteobacteria,1SMP0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_158034_1 926550.CLDAP_02040 1.14e-39 144.0 COG3385@1|root,COG3385@2|Bacteria,2G7UE@200795|Chloroflexi 200795|Chloroflexi L transposase activity - - - - - - - - - - - - - k59_93621_1 880073.Calab_3321 1.36e-90 293.0 COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_15045_2 1111134.HMPREF1253_1092 1.2e-49 183.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,22G27@1570339|Peptoniphilaceae 186801|Clostridia C Six-Cys-in-45 modification radical SAM protein scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_73541_1 448385.sce2719 0.000583 46.6 COG1357@1|root,COG5351@1|root,COG1357@2|Bacteria,COG5351@2|Bacteria,1N7U9@1224|Proteobacteria,42X3G@68525|delta/epsilon subdivisions,2WTE4@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pentapeptide repeats (8 copies) - - - - - - - - - - - - DUF2169,Pentapeptide k59_73541_2 1175306.GWL_39390 4.36e-11 65.9 COG3064@1|root,COG3064@2|Bacteria,1NJPW@1224|Proteobacteria,2VXVJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Membrane - - - - - - - - - - - - - k59_145327_1 1232683.ADIMK_2296 2.81e-07 50.8 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,463YQ@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains dctD - - ko:K08476,ko:K10126 ko02020,map02020 M00503,M00504 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_138365_1 401053.AciPR4_1878 2.54e-07 61.2 COG1956@1|root,COG2203@1|root,COG2208@1|root,COG1956@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y358@57723|Acidobacteria,2JIID@204432|Acidobacteriia 204432|Acidobacteriia T Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,SpoIIE k59_67285_1 572477.Alvin_1103 3.56e-79 259.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_67285_2 1049564.TevJSym_aa02240 1.28e-19 80.5 COG3450@1|root,COG3450@2|Bacteria,1N8CD@1224|Proteobacteria,1SAR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF861) - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_54156_1 1211815.CBYP010000024_gene1540 5.15e-18 89.0 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ETCD@85013|Frankiales 201174|Actinobacteria S Laminin G domain wcoG - - - - - - - - - - - Laminin_G_3,PKD k59_132463_1 1220534.B655_0864 1.32e-47 154.0 arCOG04849@1|root,arCOG04849@2157|Archaea,2Y3NE@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - k59_28455_1 998674.ATTE01000001_gene615 1.99e-40 142.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,460IT@72273|Thiotrichales 72273|Thiotrichales O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7,Band_7_C k59_73547_1 96561.Dole_0344 2.5e-93 293.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB-2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_119526_1 665950.HMPREF1025_02922 2.67e-60 207.0 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,247ME@186801|Clostridia,27IGQ@186928|unclassified Lachnospiraceae 186801|Clostridia L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_119526_2 1121396.KB892990_gene4486 2.74e-18 85.9 2E0F6@1|root,32W1G@2|Bacteria,1N6I3@1224|Proteobacteria,42V01@68525|delta/epsilon subdivisions,2WQWS@28221|Deltaproteobacteria,2MMAB@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_158038_1 686340.Metal_2229 2.63e-16 87.4 COG2202@1|root,COG4191@1|root,COG5000@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1T538@1236|Gammaproteobacteria,1XG6C@135618|Methylococcales 135618|Methylococcales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,PAS_3,PAS_4 k59_158038_2 1049564.TevJSym_bd00350 3.91e-93 299.0 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1J6GE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - GAF,HDOD,Pkinase k59_132466_1 1095769.CAHF01000013_gene3211 1.55e-63 211.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,475ME@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain matB - - ko:K18661 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_9088_1 1122929.KB908219_gene1787 3.08e-131 384.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_28456_1 1121405.dsmv_2719 1.86e-123 363.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MHQF@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the citrate synthase family citZ - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,HTH_17 k59_119528_1 1173024.KI912152_gene425 1.07e-82 261.0 COG5659@1|root,COG5659@2|Bacteria,1GDXT@1117|Cyanobacteria 1117|Cyanobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_99433_2 1380391.JIAS01000013_gene3781 2.78e-112 369.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JUYT@204441|Rhodospirillales 204441|Rhodospirillales S Alpha-2-Macroglobulin - - - - - - - - - - - - A2M,A2M_N,A2M_N_2 k59_151756_1 1382304.JNIL01000001_gene728 6.63e-83 266.0 COG0119@1|root,COG1024@1|root,COG0119@2|Bacteria,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli 91061|Bacilli I Belongs to the enoyl-CoA hydratase isomerase family yngF - - - - - - - - - - - ECH_1 k59_9089_1 1117315.AHCA01000010_gene997 3.15e-69 222.0 COG3119@1|root,COG3119@2|Bacteria,1P73G@1224|Proteobacteria,1RYE9@1236|Gammaproteobacteria,2Q4SR@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P PFAM sulfatase - - - - - - - - - - - - DUF4994,Sulfatase,Sulfatase_C k59_67294_2 998088.B565_3780 1.46e-39 152.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1Y3R2@135624|Aeromonadales 135624|Aeromonadales NT Cache domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_145328_2 1123400.KB904747_gene414 2.29e-56 185.0 2AHZA@1|root,318CM@2|Bacteria,1RHH8@1224|Proteobacteria,1S827@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_198581_1 443144.GM21_2502 3.26e-23 102.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_8,Response_reg k59_192595_1 1207076.ALAT01000036_gene4158 1.67e-105 318.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1Z1NZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_44733_1 1232437.KL661986_gene3674 3.63e-63 196.0 COG5418@1|root,COG5418@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_153648_1 1049564.TevJSym_av00200 7.18e-133 386.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,1SZZW@1236|Gammaproteobacteria,1JBZT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M UDP-N-acetylglucosamine 2-epimerase wecB - 5.1.3.14,5.1.3.23 ko:K01791,ko:K13019 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420,R09600 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_75596_1 1209072.ALBT01000031_gene1879 9.9e-11 66.6 COG0726@1|root,COG0726@2|Bacteria,1R7W4@1224|Proteobacteria,1RXZE@1236|Gammaproteobacteria,1FFVB@10|Cellvibrio 1236|Gammaproteobacteria G Glycosyl hydrolases family 11 - - - - - - - - - - - - CBM60,CBM_10,CBM_5_12_2,Glyco_hydro_11,Malectin,Polysacc_deac_1 k59_44738_1 472759.Nhal_0907 2.61e-34 137.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1WX8M@135613|Chromatiales 135613|Chromatiales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_179871_1 880072.Desac_1832 1.67e-86 275.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MQ88@213462|Syntrophobacterales 28221|Deltaproteobacteria H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_115012_1 768671.ThimaDRAFT_4018 9.29e-108 322.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1WX2W@135613|Chromatiales 135613|Chromatiales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_115012_2 1049564.TevJSym_cq00020 3.35e-81 253.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1J50W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_75830_1 1229172.JQFA01000004_gene1643 1.3e-34 137.0 COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1G26V@1117|Cyanobacteria,1H78U@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_128896_1 316273.XCV2482 5.21e-64 213.0 28KSJ@1|root,2ZA9W@2|Bacteria,1R9HJ@1224|Proteobacteria,1S69U@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_128896_2 232346.JHQL01000004_gene1683 2.82e-12 63.2 2EE35@1|root,33E1B@2|Bacteria,1NKKN@1224|Proteobacteria,1STR1@1236|Gammaproteobacteria,1XQGA@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_128896_3 991905.SL003B_0600 3.57e-28 110.0 28MWI@1|root,2ZB3T@2|Bacteria,1RAPA@1224|Proteobacteria,2U1GH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM plasmid encoded RepA protein repA - - - - - - - - - - - RepA_C k59_128896_4 472759.Nhal_0251 5.55e-140 402.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_50367_2 396588.Tgr7_0880 7.56e-83 253.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1X2ET@135613|Chromatiales 135613|Chromatiales F Deoxynucleoside kinase - - - - - - - - - - - - dNK k59_70222_1 177437.HRM2_49190 4.59e-187 538.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2MJ7S@213118|Desulfobacterales 28221|Deltaproteobacteria I acyl-CoA dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_166724_1 443143.GM18_3120 3.39e-58 203.0 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Serine aminopeptidase, S33 - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Acyltransferase,Hydrolase_4 k59_4321_1 1265505.ATUG01000003_gene724 1.17e-100 303.0 COG0446@1|root,COG0446@2|Bacteria,1QSGB@1224|Proteobacteria,43A36@68525|delta/epsilon subdivisions,2WZXC@28221|Deltaproteobacteria,2MP72@213118|Desulfobacterales 28221|Deltaproteobacteria S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_160709_1 425104.Ssed_0785 1.18e-19 85.9 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,2QAA3@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM glycerophosphoryl diester phosphodiesterase ugpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_160709_2 1267535.KB906767_gene2436 1.09e-22 96.3 COG0578@1|root,COG0578@2|Bacteria,3Y2YF@57723|Acidobacteria,2JI40@204432|Acidobacteriia 204432|Acidobacteriia C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_11679_1 387631.Asulf_01054 3.67e-56 186.0 COG1924@1|root,arCOG02678@2157|Archaea,2XVMQ@28890|Euryarchaeota,245WU@183980|Archaeoglobi 183980|Archaeoglobi I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_147638_1 879212.DespoDRAFT_02971 1.19e-78 249.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MIJ9@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k59_134746_1 1049564.TevJSym_ba00350 6.31e-286 803.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_134746_2 1049564.TevJSym_ba00360 1.27e-73 224.0 COG5456@1|root,COG5456@2|Bacteria,1RFTY@1224|Proteobacteria,1S4W0@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM FixH - - - - - - - - - - - - FixH k59_56189_1 335543.Sfum_1976 4.74e-31 109.0 COG1908@1|root,COG1908@2|Bacteria 2|Bacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - 1.8.98.5,1.8.98.6 ko:K14127 ko00680,map00680 - R00019,R11943,R11944 RC00011 ko00000,ko00001,ko01000 - - - FlpD,NADH_4Fe-4S k59_56189_2 387631.Asulf_01081 7.31e-11 65.1 COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,2460T@183980|Archaeoglobi 183980|Archaeoglobi C Heterodisulfide reductase subunit - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_153864_1 595460.RRSWK_06373 4.4e-28 117.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_96584_1 667014.Thein_2189 3.95e-84 278.0 COG1148@1|root,COG1148@2|Bacteria,2GHRW@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 k59_30773_2 395494.Galf_1644 0.0 1211.0 COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria 1224|Proteobacteria C Formate acetyltransferase - - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_30773_4 395494.Galf_1642 4.83e-80 248.0 COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,2WFUK@28216|Betaproteobacteria 28216|Betaproteobacteria H 4Fe-4S single cluster domain - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_30773_5 395494.Galf_1683 2.44e-168 480.0 28IH6@1|root,2Z8IF@2|Bacteria,1R4Z0@1224|Proteobacteria,2VRWN@28216|Betaproteobacteria,44WIZ@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_30773_8 666685.R2APBS1_0485 4.26e-176 511.0 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,1RQUU@1236|Gammaproteobacteria,1X4D6@135614|Xanthomonadales 135614|Xanthomonadales S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_82868_2 909663.KI867150_gene809 6.73e-15 75.1 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MQN7@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM Universal stress protein family - - - - - - - - - - - - Usp k59_82868_3 177437.HRM2_20940 4.82e-64 214.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria,2MIMQ@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF3394) - - - - - - - - - - - - DUF3394,DctM k59_50372_1 1049564.TevJSym_am00120 1.6e-116 337.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1J51P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186 Pribosyltran k59_50372_2 1049564.TevJSym_am00100 3.08e-96 297.0 COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_50372_3 1049564.TevJSym_am00090 1.84e-52 171.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1J5T9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_187031_1 1430331.EP10_15215 1.69e-49 175.0 COG1943@1|root,COG3599@1|root,COG1943@2|Bacteria,COG3599@2|Bacteria,1TRNH@1239|Firmicutes,4HHNJ@91061|Bacilli,1WGZX@129337|Geobacillus 91061|Bacilli DL Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_147654_1 246200.SPO0479 1.1e-53 180.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,4NDP6@97050|Ruegeria 28211|Alphaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_89172_1 936455.KI421499_gene8006 4e-25 104.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,3JTPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP MA20_09645 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_89172_2 1283300.ATXB01000001_gene2429 7.45e-45 155.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1XG4P@135618|Methylococcales 135618|Methylococcales T Two component signalling adaptor domain - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_44993_1 1123257.AUFV01000001_gene1833 2.25e-51 175.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1X4M9@135614|Xanthomonadales 135614|Xanthomonadales G phosphomannomutase xanA - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_44993_2 1408445.JHXP01000006_gene128 2.3e-65 215.0 COG1216@1|root,COG1216@2|Bacteria,1QV94@1224|Proteobacteria,1T4ZA@1236|Gammaproteobacteria,1JGMQ@118969|Legionellales 118969|Legionellales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_44993_3 118161.KB235922_gene3798 3.57e-19 97.8 COG2244@1|root,COG2244@2|Bacteria,1G2BA@1117|Cyanobacteria,3VHQ7@52604|Pleurocapsales 1117|Cyanobacteria S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_44993_4 293613.A1E_03785 1.29e-67 223.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups wbbK GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_44993_5 1396.DJ87_3931 2.04e-08 62.8 COG0438@1|root,COG0438@2|Bacteria,1UTQH@1239|Firmicutes,4HDWV@91061|Bacilli,1ZB8Y@1386|Bacillus 91061|Bacilli M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_122484_1 1499967.BAYZ01000119_gene3224 4.52e-59 193.0 KOG2524@1|root,2ZJ84@2|Bacteria 2|Bacteria S Potential Queuosine, Q, salvage protein family - - - - - - - - - - - - Q_salvage k59_37712_1 1049564.TevJSym_ab01220 1.88e-76 233.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1J6RE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Molybdopterin-guanine dinucleotide biosynthesis protein mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.7.77 ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 MobB k59_198859_2 748247.AZKH_p0100 2.27e-22 102.0 COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,2VVEE@28216|Betaproteobacteria 28216|Betaproteobacteria GM NmrA-like family azoB - - - - - - - - - - - NmrA k59_75862_1 1049564.TevJSym_bs00060 5.37e-129 386.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1J517@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_24704_3 1121935.AQXX01000093_gene3413 1.96e-136 393.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1XHPG@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_37717_1 626887.J057_01665 1.28e-16 80.5 28I8X@1|root,2Z8BQ@2|Bacteria,1MW9X@1224|Proteobacteria,1RR0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_160737_1 641107.CDLVIII_1329 2.32e-21 101.0 COG4974@1|root,COG4974@2|Bacteria,1TQXV@1239|Firmicutes,24884@186801|Clostridia,36HA0@31979|Clostridiaceae 186801|Clostridia L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_134772_1 1288826.MSNKSG1_12492 1.09e-46 155.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,465KW@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0155,iYL1228.KPN_03757 Ribul_P_3_epim k59_134772_2 870187.Thini_3915 1.06e-11 62.8 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,4602N@72273|Thiotrichales 72273|Thiotrichales G TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_192869_1 1049564.TevJSym_an00790 3.52e-30 110.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1J4K8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N k59_173138_3 1463936.JOJI01000012_gene6351 6.51e-76 250.0 COG0693@1|root,COG4977@1|root,COG0693@2|Bacteria,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_63811_4 1038922.PflQ2_3999 2.27e-05 47.4 COG1943@1|root,COG1943@2|Bacteria,1R75U@1224|Proteobacteria,1S1SP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_56351_1 1056820.KB900674_gene2506 2.06e-89 276.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria,2PQ0I@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Type VI secretion protein, EvpB/VC_A0108, tail sheath impC - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_115237_1 1232410.KI421424_gene1697 4.51e-08 53.5 COG1410@1|root,COG1410@2|Bacteria,1NSVT@1224|Proteobacteria 1224|Proteobacteria E Pterin binding enzyme - - - - - - - - - - - - Pterin_bind k59_115237_2 760568.Desku_1204 2.98e-28 117.0 COG3894@1|root,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260DA@186807|Peptococcaceae 186801|Clostridia C PFAM 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - DUF4445,Fer2 k59_4516_1 1249627.D779_3352 7.83e-189 565.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_96818_1 1249627.D779_4160 4.01e-58 201.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WXJB@135613|Chromatiales 135613|Chromatiales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_109166_2 1219076.N646_0446 3.67e-15 70.9 COG1943@1|root,COG1943@2|Bacteria,1RI1H@1224|Proteobacteria,1T1BV@1236|Gammaproteobacteria,1Y31Q@135623|Vibrionales 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_102025_1 698757.Pogu_0656 1.41e-36 137.0 COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota 28889|Crenarchaeota E in RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,Fer4_6,RLI k59_96821_1 926550.CLDAP_17060 5.16e-82 248.0 COG3415@1|root,COG3415@2|Bacteria,2G8GG@200795|Chloroflexi 200795|Chloroflexi L InterPro IPR009057 - - - - - - - - - - - - HTH_32 k59_96821_2 272134.KB731326_gene141 1.87e-23 95.5 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_63812_1 1328313.DS2_00655 0.000442 52.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,466BR@72275|Alteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - CHASE,EAL,GGDEF,HAMP,PAS_3,PAS_9,dCache_1 ## 11695 queries scanned ## Total time (seconds): 97.44765591621399 ## Rate: 120.01 q/s