## Tue Sep 3 02:52:56 2024 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/salt_marsh/mmseqs_cluster/PRJNA714626/SRR13969206/SRR13969206_p_cluster_rep_seq.fasta --output PRJNA714626_SRR13969206 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/salt_marsh/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k141_162_10 931276.Cspa_c03600 4.12e-57 200.0 COG2244@1|root,COG2244@2|Bacteria,1VPUV@1239|Firmicutes,24CH7@186801|Clostridia,36GWF@31979|Clostridiaceae 186801|Clostridia S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt k141_162_11 573061.Clocel_0962 2.64e-159 459.0 COG0438@1|root,COG0438@2|Bacteria,1UYSU@1239|Firmicutes,24EIH@186801|Clostridia,36HKX@31979|Clostridiaceae 186801|Clostridia M Glycosyl transferases group 1 - - 2.4.1.11 ko:K16150 ko00500,ko01100,map00500,map01100 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k141_162_12 349520.PPE_03727 3.24e-99 300.0 COG1215@1|root,COG1215@2|Bacteria,1TRYI@1239|Firmicutes,4HUE2@91061|Bacilli,26W7H@186822|Paenibacillaceae 91061|Bacilli M involved in cell wall biogenesis kfoC - - - - - - - - - - - Glycos_transf_2 k141_162_13 1304885.AUEY01000033_gene1920 1.47e-23 102.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R7R@68525|delta/epsilon subdivisions,2WMT0@28221|Deltaproteobacteria,2MJMX@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - GerE,HATPase_c,HisKA,PAS,Response_reg k141_162_14 931276.Cspa_c03660 3.16e-123 367.0 COG0463@1|root,COG0463@2|Bacteria,1UE0C@1239|Firmicutes,249GE@186801|Clostridia,36HGZ@31979|Clostridiaceae 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k141_162_15 573061.Clocel_0969 0.0 1262.0 COG2244@1|root,COG2244@2|Bacteria,1UZBQ@1239|Firmicutes,24C4B@186801|Clostridia,36FZB@31979|Clostridiaceae 186801|Clostridia S polysaccharide biosynthetic process - - - - - - - - - - - - - k141_162_16 1121324.CLIT_10c03380 1.96e-21 103.0 2BBX0@1|root,325FF@2|Bacteria,1URHA@1239|Firmicutes,24X0N@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_162_21 1391647.AVSV01000028_gene284 2.88e-19 84.7 2E70J@1|root,331JD@2|Bacteria,1VGGS@1239|Firmicutes,24JJ2@186801|Clostridia,36JT3@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_162_22 1294142.CINTURNW_2858 1.8e-07 51.2 2E97I@1|root,333G1@2|Bacteria,1VGBC@1239|Firmicutes,24PN9@186801|Clostridia,36M64@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF1292) - - - - - - - - - - - - DUF1292 k141_162_23 431943.CKL_2331 1.78e-214 606.0 COG1027@1|root,COG1027@2|Bacteria,1TP3U@1239|Firmicutes,2483Z@186801|Clostridia,36DQI@31979|Clostridiaceae 186801|Clostridia E Aspartate ammonia-lyase ansB - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS20875 FumaraseC_C,Lyase_1 k141_162_24 431943.CKL_2330 3.41e-211 593.0 COG1160@1|root,COG1160@2|Bacteria,1UI84@1239|Firmicutes,25EDI@186801|Clostridia,36UM4@31979|Clostridiaceae 186801|Clostridia S small GTP-binding protein hydF - - - - - - - - - - - MMR_HSR1 k141_162_26 1286171.EAL2_808p06350 1.37e-148 425.0 COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,25VF3@186806|Eubacteriaceae 186801|Clostridia H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k141_162_27 1122172.KB890259_gene1292 3.79e-74 228.0 COG0311@1|root,COG0311@2|Bacteria,37A0Y@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO k141_162_28 293826.Amet_1114 6.48e-47 159.0 2BYWB@1|root,331N7@2|Bacteria,1VC73@1239|Firmicutes,24NV6@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF3793) - - - - - - - - - - - - DUF3793 k141_162_29 1408422.JHYF01000014_gene261 1.76e-150 441.0 COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,36FIT@31979|Clostridiaceae 186801|Clostridia E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k141_162_30 1347392.CCEZ01000049_gene1303 4.5e-155 466.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36FNE@31979|Clostridiaceae 186801|Clostridia KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k141_162_32 1304284.L21TH_1988 7.22e-50 167.0 COG2431@1|root,COG2431@2|Bacteria,1V44M@1239|Firmicutes,24I3B@186801|Clostridia,36ID9@31979|Clostridiaceae 186801|Clostridia S Lysine exporter LysO - - - - - - - - - - - - Lys_export k141_162_33 941824.TCEL_00268 8.08e-53 171.0 COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,36JJ0@31979|Clostridiaceae 186801|Clostridia E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k141_162_34 536227.CcarbDRAFT_2018 7.17e-38 134.0 COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,36JKN@31979|Clostridiaceae 186801|Clostridia F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k141_162_36 1121324.CLIT_20c00290 4.35e-288 799.0 COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia 186801|Clostridia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k141_162_37 1121324.CLIT_20c00280 2.61e-46 150.0 COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,25RM6@186804|Peptostreptococcaceae 186801|Clostridia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k141_162_38 1226325.HMPREF1548_05535 9.34e-238 665.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36E1P@31979|Clostridiaceae 186801|Clostridia C glutamate synthase (NADPH), homotetrameric gltA - 1.17.1.9,1.4.1.13,1.4.1.14 ko:K00123,ko:K00266 ko00250,ko00630,ko00680,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00250,map00630,map00680,map00910,map01100,map01110,map01120,map01130,map01200,map01230 - R00093,R00114,R00248,R00519 RC00006,RC00010,RC02796,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k141_162_39 999411.HMPREF1092_02299 3.05e-154 439.0 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,36DFV@31979|Clostridiaceae 186801|Clostridia C Oxidoreductase pyrK_1 - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k141_162_40 536232.CLM_1884 4.99e-213 596.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,36DKD@31979|Clostridiaceae 186801|Clostridia C alcohol dehydrogenase adh - - - - - - - - - - - Fe-ADH k141_162_41 536232.CLM_1431 6.69e-08 54.3 COG5416@1|root,COG5416@2|Bacteria,1VK4W@1239|Firmicutes,24RJX@186801|Clostridia,36NC1@31979|Clostridiaceae 186801|Clostridia S Lipopolysaccharide assembly protein A domain - - - - - - - - - - - - LapA_dom k141_162_43 1347392.CCEZ01000049_gene1331 4.05e-125 378.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE k141_162_44 926692.AZYG01000094_gene1965 3.99e-29 122.0 COG0726@1|root,COG0726@2|Bacteria,1V4PK@1239|Firmicutes,25BCW@186801|Clostridia,3WBMS@53433|Halanaerobiales 186801|Clostridia M PFAM Polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - LysM,Polysacc_deac_1 k141_162_45 457421.CBFG_00856 2.03e-41 151.0 2DBFK@1|root,2Z8Z7@2|Bacteria,1TQKG@1239|Firmicutes,2482J@186801|Clostridia,2688R@186813|unclassified Clostridiales 186801|Clostridia S Protein of unknown function (DUF3298) - - - - - - - - - - - - DUF3298,DUF4163 k141_162_46 1297617.JPJD01000072_gene1815 2.33e-29 112.0 COG1595@1|root,COG1595@2|Bacteria,1V734@1239|Firmicutes,24MQB@186801|Clostridia,268VU@186813|unclassified Clostridiales 186801|Clostridia K Sigma-70, region 4 sigV - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k141_162_47 1286171.EAL2_c17530 8.79e-223 629.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,25UTH@186806|Eubacteriaceae 186801|Clostridia I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k141_162_48 1347392.CCEZ01000007_gene2010 3.41e-105 315.0 COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,36DTH@31979|Clostridiaceae 186801|Clostridia L 8-oxoguanine DNA glycosylase alkA - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,OGG_N k141_162_49 1292035.H476_3153 5.41e-127 376.0 COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia 186801|Clostridia H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT - 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT k141_162_51 318464.IO99_07650 1.68e-64 214.0 COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,36WDV@31979|Clostridiaceae 186801|Clostridia EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 k141_184_1 1280692.AUJL01000004_gene832 4.23e-35 139.0 COG3266@1|root,COG3266@2|Bacteria,1UNJR@1239|Firmicutes,25HET@186801|Clostridia,36VAC@31979|Clostridiaceae 186801|Clostridia S Siphovirus ReqiPepy6 Gp37-like protein - - - - - - - - - - - - Collagen,Sipho_Gp37 k141_184_2 1589749.A0A0B5A4Y7_9CAUD 1.84e-41 163.0 4QM2Z@10699|Siphoviridae 10699|Siphoviridae S cell adhesion - - - - - - - - - - - - - k141_184_3 767817.Desgi_4494 4.28e-56 189.0 COG4722@1|root,COG4722@2|Bacteria,1V3B1@1239|Firmicutes,24G0I@186801|Clostridia,265HD@186807|Peptococcaceae 186801|Clostridia S PFAM Phage tail protein - - - - - - - - - - - - Sipho_tail k141_184_4 1405498.SSIM_10965 1.31e-74 283.0 COG0739@1|root,COG3953@1|root,COG5283@1|root,COG5412@1|root,COG0739@2|Bacteria,COG3953@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,4HAFE@91061|Bacilli,4GY27@90964|Staphylococcaceae 91061|Bacilli M Phage tail tape measure protein - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k141_184_6 536233.CLO_0548 7.05e-31 115.0 28UBF@1|root,2ZGGV@2|Bacteria,1W48W@1239|Firmicutes,24ISP@186801|Clostridia,36IPP@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_7 332101.JIBU02000023_gene4729 1.22e-56 188.0 2EPUD@1|root,33HEV@2|Bacteria,1VQ67@1239|Firmicutes,24F12@186801|Clostridia,36GH8@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_9 1443122.Z958_05860 9.39e-35 122.0 2EF0N@1|root,338TS@2|Bacteria,1UBZQ@1239|Firmicutes,24RA8@186801|Clostridia,36MZZ@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_10 536233.CLO_0543 1.39e-22 92.4 2ADX2@1|root,313P6@2|Bacteria,1UHF9@1239|Firmicutes,24RWS@186801|Clostridia,36MW3@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_11 1443122.Z958_05850 1.63e-29 108.0 2BETZ@1|root,30HCB@2|Bacteria,1UHFM@1239|Firmicutes,24RXA@186801|Clostridia,36NI1@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_13 1415774.U728_828 4.85e-180 509.0 28PY7@1|root,2ZCHY@2|Bacteria,1V2M7@1239|Firmicutes,24CTQ@186801|Clostridia,36H3Q@31979|Clostridiaceae 186801|Clostridia S Phage major capsid protein E - - - - - - - - - - - - Phage_cap_E k141_184_14 748727.CLJU_c31320 9.46e-20 84.7 2BAU4@1|root,3249E@2|Bacteria,1UQKG@1239|Firmicutes,24U9Y@186801|Clostridia,36MJG@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_15 1121342.AUCO01000012_gene1696 6.54e-26 107.0 2DPCU@1|root,331IS@2|Bacteria,1UPSP@1239|Firmicutes,25HNC@186801|Clostridia,36VBI@31979|Clostridiaceae 186801|Clostridia S Phage minor structural protein GP20 - - - - - - - - - - - - Phage_GP20 k141_184_19 1121342.AUCO01000012_gene1699 3.42e-84 263.0 29XPS@1|root,30JFE@2|Bacteria,1UKZ4@1239|Firmicutes,24BJ4@186801|Clostridia,36GV7@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_20 1121342.AUCO01000012_gene1700 1.51e-180 524.0 2EQUX@1|root,33IEQ@2|Bacteria,1W342@1239|Firmicutes,24991@186801|Clostridia,36G9P@31979|Clostridiaceae 186801|Clostridia S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k141_184_21 756499.Desde_1076 4.47e-218 613.0 COG1783@1|root,COG1783@2|Bacteria,1TT2C@1239|Firmicutes,24A7T@186801|Clostridia,261RB@186807|Peptococcaceae 186801|Clostridia S TIGRFAM Phage terminase, large subunit, PBSX - - - - - - - - - - - - Terminase_6,Terminase_6C k141_184_22 1567015.A0A0A7S1A8_9VIRU 7.66e-79 253.0 4QB6U@10239|Viruses 10239|Viruses S Terminase small subunit - - - - - - - - - - - - - k141_184_23 318464.IO99_13795 9.73e-22 94.7 COG1595@1|root,COG1595@2|Bacteria,1V2TE@1239|Firmicutes,24GMM@186801|Clostridia,36ISW@31979|Clostridiaceae 186801|Clostridia K DNA-templated transcription, initiation - - - - - - - - - - - - - k141_184_24 546269.HMPREF0389_01237 8.62e-36 128.0 COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,25RHZ@186804|Peptostreptococcaceae 186801|Clostridia L Single-strand binding protein family ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k141_184_29 1391647.AVSV01000022_gene2538 1.9e-16 73.2 2BB9Y@1|root,324SP@2|Bacteria,1UQZ4@1239|Firmicutes,24VBZ@186801|Clostridia,36PCV@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_184_35 931626.Awo_c35220 8.15e-23 103.0 COG3935@1|root,COG3935@2|Bacteria,1VAP8@1239|Firmicutes 1239|Firmicutes L DnaD domain protein - - - - - - - - - - - - - k141_184_36 1280706.AUJE01000003_gene2279 4.86e-56 188.0 COG3723@1|root,COG3723@2|Bacteria,1UNDF@1239|Firmicutes,4H38J@909932|Negativicutes 909932|Negativicutes L Recombinase, phage RecT family recT - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k141_184_41 1089548.KI783301_gene2641 3.01e-13 70.5 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,4HR82@91061|Bacilli 91061|Bacilli K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k141_184_42 485916.Dtox_2431 7.74e-07 54.3 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_19,HTH_3 k141_184_43 696281.Desru_1066 8.45e-34 123.0 COG2856@1|root,COG2856@2|Bacteria,1V4N6@1239|Firmicutes,24JDG@186801|Clostridia,262CF@186807|Peptococcaceae 186801|Clostridia E Pfam:DUF955 - - - - - - - - - - - - Peptidase_M78 k141_184_44 556268.OFAG_02316 5.01e-62 228.0 COG0326@1|root,COG0326@2|Bacteria,1RJYD@1224|Proteobacteria 1224|Proteobacteria L Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c_3 k141_184_45 1217713.F993_01554 2.95e-136 402.0 COG0863@1|root,COG0863@2|Bacteria,1RI4J@1224|Proteobacteria,1SGZ6@1236|Gammaproteobacteria,3NTEP@468|Moraxellaceae 1236|Gammaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k141_184_49 1123252.ATZF01000014_gene4248 1.22e-15 74.7 2E3YM@1|root,32YVJ@2|Bacteria,1VGJD@1239|Firmicutes,4HQK0@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - SmpA_OmlA k141_184_52 1304284.L21TH_1778 9.45e-51 177.0 COG5464@1|root,COG5464@2|Bacteria,1TPB1@1239|Firmicutes,24B0D@186801|Clostridia,36GBY@31979|Clostridiaceae 186801|Clostridia S PD-(D/E)XK nuclease family transposase - - - - - - - - - - - - DUF4351,PDDEXK_2 k141_18_45 908340.HMPREF9406_3901 5.39e-169 493.0 COG1129@1|root,COG1129@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,36UGY@31979|Clostridiaceae 186801|Clostridia G ABC transporter, ATP-binding protein - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k141_18_46 1118055.CAGU01000013_gene746 2.06e-200 570.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,22GF0@1570339|Peptoniphilaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE k141_18_47 1499689.CCNN01000006_gene415 2.84e-247 694.0 28HH2@1|root,2Z7ST@2|Bacteria,1UYQU@1239|Firmicutes,248KR@186801|Clostridia,36FIU@31979|Clostridiaceae 186801|Clostridia M Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex pfo - - ko:K11031 ko02024,map02024 - - - ko00000,ko00001,ko02042 - - - Thiol_cytolys_C,Thiol_cytolysin k141_18_49 293826.Amet_4170 3.61e-60 196.0 2EQ5N@1|root,33HRY@2|Bacteria,1VP67@1239|Firmicutes,24UWY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_243_100 555079.Toce_1763 1.02e-62 196.0 COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,42G14@68295|Thermoanaerobacterales 186801|Clostridia H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) luxS - 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 - - - LuxS k141_243_101 986075.CathTA2_1461 1.01e-94 290.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli 91061|Bacilli E Belongs to the cysteine synthase cystathionine beta- synthase family mccA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042127,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0065007,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.134,2.5.1.47 ko:K01738,ko:K17216 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00609 R00897,R03601,R04859,R10305 RC00020,RC00069,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS02385 PALP k141_243_102 865861.AZSU01000001_gene374 3.59e-74 226.0 COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia,36IWX@31979|Clostridiaceae 186801|Clostridia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k141_243_103 1151292.QEW_1535 2.34e-307 853.0 COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,25QYC@186804|Peptostreptococcaceae 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k141_243_104 1304880.JAGB01000003_gene1158 7e-34 128.0 COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia 186801|Clostridia S Radical SAM-linked protein - - - - - - - - - - - - DUF2344 k141_243_105 717605.Theco_1666 6.42e-18 89.7 COG3103@1|root,COG4193@1|root,COG3103@2|Bacteria,COG4193@2|Bacteria,1V3FK@1239|Firmicutes,4HG9J@91061|Bacilli,26WYR@186822|Paenibacillaceae 91061|Bacilli GT Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - - - - - - - - - - Glucosaminidase,SH3_3,SH3_8 k141_243_107 484770.UFO1_0315 7.4e-97 293.0 COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,4H5B4@909932|Negativicutes 909932|Negativicutes K Transcriptional regulator, RpiR family - - - - - - - - - - - - HTH_6,SIS k141_243_108 293826.Amet_2638 2.08e-235 659.0 COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,36UI3@31979|Clostridiaceae 186801|Clostridia C carboxyltransferase pycB - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - HMGL-like,PYC_OADA k141_243_109 37659.JNLN01000001_gene237 3.7e-41 142.0 COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,36HY4@31979|Clostridiaceae 186801|Clostridia S membrane - - - - - - - - - - - - QueT k141_243_110 332101.JIBU02000043_gene1505 9.76e-109 319.0 COG1244@1|root,COG1244@2|Bacteria,1UZ5M@1239|Firmicutes,24AIM@186801|Clostridia,36G6G@31979|Clostridiaceae 186801|Clostridia S Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - - k141_243_111 1219035.NT2_04_03790 9.54e-10 60.8 COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria,2K66W@204457|Sphingomonadales 204457|Sphingomonadales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k141_243_112 1304284.L21TH_2085 1.93e-179 512.0 COG1972@1|root,COG1972@2|Bacteria,1TRSK@1239|Firmicutes,249IZ@186801|Clostridia,36FNG@31979|Clostridiaceae 186801|Clostridia F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k141_243_113 1121289.JHVL01000022_gene1148 4.28e-159 464.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k141_243_114 1278306.KB906926_gene1672 5.71e-43 165.0 COG1530@1|root,COG1530@2|Bacteria,378E6@32066|Fusobacteria 32066|Fusobacteria J Ribonuclease E/G family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k141_243_115 272563.CD630_11610 4.08e-47 153.0 COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,25RS2@186804|Peptostreptococcaceae 186801|Clostridia J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k141_243_116 1273103.NM10_09088 8.4e-18 79.3 COG2868@1|root,COG2868@2|Bacteria,1TU8A@1239|Firmicutes,4H5SB@909932|Negativicutes 909932|Negativicutes J Cysteine protease Prp - - - ko:K07584 - - - - ko00000 - - - Peptidase_Prp k141_243_117 546269.HMPREF0389_00430 3.22e-46 150.0 COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,25RK1@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k141_243_120 1511.CLOST_1371 1.5e-205 580.0 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25QXG@186804|Peptostreptococcaceae 186801|Clostridia S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k141_243_121 1280689.AUJC01000001_gene2244 2.38e-26 100.0 COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia,36KS2@31979|Clostridiaceae 186801|Clostridia J RNA-binding protein yhbY - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k141_243_123 1151292.QEW_3070 1.83e-77 238.0 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,25QZS@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k141_243_124 864565.HMPREF0379_0896 1.12e-49 172.0 COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia,25RIB@186804|Peptostreptococcaceae 186801|Clostridia H Hydrolase, HD family nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,HD k141_243_125 1121324.CLIT_23c03500 2.02e-112 335.0 COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia 186801|Clostridia K TIGRFAM cell envelope-related function transcriptional attenuator lytR - - - - - - - - - - - LytR_C,LytR_cpsA_psr k141_243_126 936154.STP_1396 2.87e-29 109.0 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,4HKEJ@91061|Bacilli 91061|Bacilli J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k141_243_127 1121324.CLIT_23c03520 0.0 1266.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,25QI2@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k141_243_128 394503.Ccel_3208 5.36e-74 238.0 COG3081@1|root,COG3081@2|Bacteria,1TSR5@1239|Firmicutes,25CG3@186801|Clostridia,36WVH@31979|Clostridiaceae 186801|Clostridia S 37-kD nucleoid-associated bacterial protein - - - - - - - - - - - - NA37 k141_243_129 1031288.AXAA01000005_gene2107 7.42e-177 505.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,36EUA@31979|Clostridiaceae 186801|Clostridia E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k141_243_130 748727.CLJU_c21680 9.78e-28 106.0 COG0517@1|root,COG0517@2|Bacteria,1VI1R@1239|Firmicutes,24KIA@186801|Clostridia,36JY1@31979|Clostridiaceae 186801|Clostridia S CBS domain - - - - - - - - - - - - CBS k141_243_131 1121324.CLIT_23c03570 3e-185 527.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,25QIV@186804|Peptostreptococcaceae 186801|Clostridia E threonine ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP k141_243_132 1121324.CLIT_23c03580 3.82e-70 213.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,25RF5@186804|Peptostreptococcaceae 186801|Clostridia J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k141_243_133 1121324.CLIT_23c03590 1.12e-99 295.0 COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, beta subunit sdaAB - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - ACT,SDH_beta k141_243_134 350688.Clos_1741 3.25e-125 365.0 COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia,36DCQ@31979|Clostridiaceae 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, alpha subunit sdaAA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha k141_243_135 1121324.CLIT_23c03610 2.8e-45 151.0 COG0593@1|root,COG0593@2|Bacteria,1VAFE@1239|Firmicutes,25E3U@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_243_136 796940.HMPREF9628_01952 1.8e-111 341.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,25QXI@186804|Peptostreptococcaceae 186801|Clostridia M D-Ala-D-Ala carboxypeptidase 3 (S13) family dacB - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k141_243_137 1408823.AXUS01000003_gene531 1.92e-33 127.0 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,25RI8@186804|Peptostreptococcaceae 186801|Clostridia L Helix-hairpin-helix motif comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k141_243_138 350688.Clos_1738 1.3e-121 360.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,36DGY@31979|Clostridiaceae 186801|Clostridia E Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k141_243_140 1391646.AVSU01000046_gene1548 1.58e-195 558.0 COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,25R1B@186804|Peptostreptococcaceae 186801|Clostridia J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA - 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k141_243_141 1121324.CLIT_23c03660 6.48e-226 648.0 COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,25QGF@186804|Peptostreptococcaceae 186801|Clostridia J Elongation factor SelB, winged helix selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k141_243_142 1408422.JHYF01000001_gene2677 6.49e-99 294.0 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,36W97@31979|Clostridiaceae 186801|Clostridia T PFAM response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k141_243_143 97137.C821_00188 6.56e-33 139.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,3F45G@33958|Lactobacillaceae 91061|Bacilli T Histidine kinase vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k141_243_144 574087.Acear_1807 1.6e-13 75.1 COG5401@1|root,COG5401@2|Bacteria,1UEAR@1239|Firmicutes,25J65@186801|Clostridia,3WBX7@53433|Halanaerobiales 186801|Clostridia S Sporulation and spore germination - - - - - - - - - - - - Germane k141_243_145 1347392.CCEZ01000043_gene503 7.41e-210 588.0 COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae 186801|Clostridia F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k141_243_146 324057.Pjdr2_3497 1.55e-11 67.4 COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,4HM44@91061|Bacilli,26UF3@186822|Paenibacillaceae 91061|Bacilli S metal-binding, possibly nucleic acid-binding protein - - - ko:K07040 - - - - ko00000 - - - DUF177 k141_243_147 1443122.Z958_02630 4.26e-18 76.6 COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,36MII@31979|Clostridiaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k141_243_148 1121324.CLIT_23c03710 4e-82 248.0 COG1349@1|root,COG1349@2|Bacteria,1V3MJ@1239|Firmicutes,24BT7@186801|Clostridia 186801|Clostridia K regulatory protein, DeoR fapR - - - - - - - - - - - 4HBT,HTH_DeoR k141_243_149 1443122.Z958_02635 3.75e-109 328.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,36E96@31979|Clostridiaceae 186801|Clostridia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k141_243_150 273068.TTE1475 3.75e-151 434.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k141_243_151 1286171.EAL2_c11910 4.34e-149 427.0 COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,25USN@186806|Eubacteriaceae 186801|Clostridia S reductase II fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - iHN637.CLJU_RS20775 NMO k141_243_152 1391646.AVSU01000032_gene2326 9.71e-116 343.0 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,25RFG@186804|Peptostreptococcaceae 186801|Clostridia I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k141_243_153 1408823.AXUS01000005_gene2546 3.12e-95 286.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,25R8Y@186804|Peptostreptococcaceae 186801|Clostridia IQ 3-oxoacyl- acyl-carrier-protein reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k141_243_154 293826.Amet_1223 6.49e-27 100.0 COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia 186801|Clostridia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k141_243_155 1391646.AVSU01000032_gene2323 3.89e-220 616.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,25QQD@186804|Peptostreptococcaceae 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k141_243_156 293826.Amet_0844 8.61e-170 489.0 2DCK4@1|root,32TZT@2|Bacteria,1VCBP@1239|Firmicutes,24ZG9@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_243_157 293826.Amet_0845 2.02e-71 220.0 2EQ8E@1|root,33HUP@2|Bacteria,1VPWX@1239|Firmicutes,2520Z@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_243_158 293826.Amet_0846 0.0 910.0 COG1196@1|root,COG1196@2|Bacteria,1UZCT@1239|Firmicutes,24FJ5@186801|Clostridia 186801|Clostridia D nuclear chromosome segregation - - - - - - - - - - - - AAA_23 k141_243_159 536227.CcarbDRAFT_2200 2.15e-81 242.0 COG5561@1|root,COG5561@2|Bacteria,1VE2W@1239|Firmicutes,24HE2@186801|Clostridia,36ISA@31979|Clostridiaceae 186801|Clostridia S metal-binding protein - - - - - - - - - - - - CGGC k141_243_160 880070.Cycma_2302 1.96e-33 120.0 COG2315@1|root,COG2315@2|Bacteria,4NS6J@976|Bacteroidetes,47R6I@768503|Cytophagia 976|Bacteroidetes S YjbR - - - - - - - - - - - - YjbR k141_243_163 1121324.CLIT_23c03790 6.47e-49 159.0 COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia,25RIH@186804|Peptostreptococcaceae 186801|Clostridia S Asp23 family, cell envelope-related function asp - - - - - - - - - - - Asp23 k141_243_164 1161902.HMPREF0378_0564 2.62e-23 94.7 COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,3WDJZ@538999|Clostridiales incertae sedis 186801|Clostridia K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k141_243_165 500633.CLOHIR_01144 9.5e-76 242.0 COG0533@1|root,COG0533@2|Bacteria,1TRPY@1239|Firmicutes,24CN4@186801|Clostridia,25SPG@186804|Peptostreptococcaceae 186801|Clostridia O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction gcp1 - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k141_243_166 1121324.CLIT_23c03820 1.45e-114 347.0 COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,25QJ1@186804|Peptostreptococcaceae 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k141_243_167 1121324.CLIT_23c03830 2.17e-12 63.2 COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k141_243_168 1301100.HG529233_gene7387 3.72e-117 345.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,36EGM@31979|Clostridiaceae 186801|Clostridia H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - iHN637.CLJU_RS05465 polyprenyl_synt k141_243_169 1121324.CLIT_23c03850 4.06e-64 199.0 COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,24MV7@186801|Clostridia,25RHI@186804|Peptostreptococcaceae 186801|Clostridia S Divergent PAP2 family - - - ko:K09775 - - - - ko00000 - - - DUF212 k141_243_170 1304284.L21TH_0189 1.34e-34 128.0 COG1253@1|root,COG1253@2|Bacteria,1VBH3@1239|Firmicutes,24NJQ@186801|Clostridia,36IUM@31979|Clostridiaceae 186801|Clostridia S flavin adenine dinucleotide binding - - - - - - - - - - - - - k141_243_171 1121324.CLIT_23c03870 7.11e-263 741.0 COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,25QT2@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k141_243_172 1499684.CCNP01000020_gene2307 1.91e-120 352.0 COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,36EDU@31979|Clostridiaceae 186801|Clostridia J Methyltransferase rrmJ - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k141_243_173 1286171.EAL2_c12060 1.61e-65 203.0 COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,25WB7@186806|Eubacteriaceae 186801|Clostridia K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k141_243_174 500633.CLOHIR_01151 2.92e-141 427.0 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,25QYR@186804|Peptostreptococcaceae 186801|Clostridia L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k141_243_175 37659.JNLN01000001_gene2420 5.43e-92 280.0 COG0745@1|root,COG0745@2|Bacteria,1TPF7@1239|Firmicutes,24916@186801|Clostridia,36EFI@31979|Clostridiaceae 186801|Clostridia KT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process spo0A - - ko:K07699 ko02020,ko02024,map02020,map02024 M00485 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Spo0A_C k141_243_176 1286171.EAL2_c12150 6.2e-159 457.0 COG4825@1|root,COG4825@2|Bacteria,1TQ8Q@1239|Firmicutes,24B4X@186801|Clostridia 186801|Clostridia S PFAM Thiamin pyrophosphokinase catalytic - - - - - - - - - - - - MAF_flag10,TPPK_C k141_243_177 1121324.CLIT_23c04090 5.56e-62 204.0 28JWD@1|root,2Z9M5@2|Bacteria,1UZF1@1239|Firmicutes,24HZN@186801|Clostridia,25T02@186804|Peptostreptococcaceae 186801|Clostridia S Copper transport outer membrane protein, MctB - - - - - - - - - - - - MctB k141_243_178 1511.CLOST_1337 8.47e-71 223.0 COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,25KCB@186801|Clostridia,25QQF@186804|Peptostreptococcaceae 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glycos_transf_2 k141_243_179 445973.CLOBAR_02243 2.67e-56 189.0 COG0472@1|root,COG0472@2|Bacteria,1V7C4@1239|Firmicutes,24K6E@186801|Clostridia,25R28@186804|Peptostreptococcaceae 186801|Clostridia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan - - - - - - - - - - - - Glycos_transf_4 k141_243_180 445973.CLOBAR_02242 3.12e-131 386.0 COG3502@1|root,COG3502@2|Bacteria,1TQW1@1239|Firmicutes,24952@186801|Clostridia,25R2G@186804|Peptostreptococcaceae 186801|Clostridia S Protein of unknown function (DUF3866) - - - - - - - - - - - - DUF3866 k141_243_181 1128398.Curi_c14020 4.9e-66 207.0 COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,268ZS@186813|unclassified Clostridiales 186801|Clostridia L NUDIX domain nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k141_243_182 1151292.QEW_1600 1.98e-91 280.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,25QDH@186804|Peptostreptococcaceae 186801|Clostridia L Belongs to the 'phage' integrase family xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k141_243_183 1292035.H476_1985 3.95e-206 578.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,25QPX@186804|Peptostreptococcaceae 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme k141_243_184 1301100.HG529268_gene607 3.75e-137 394.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,36E47@31979|Clostridiaceae 186801|Clostridia F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k141_243_185 398511.BpOF4_14770 4.82e-116 341.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,1ZEQS@1386|Bacillus 91061|Bacilli F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1,2.4.2.28 ko:K00772,ko:K03783 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k141_243_186 1476973.JMMB01000007_gene988 2.15e-208 588.0 COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,25T0Q@186804|Peptostreptococcaceae 186801|Clostridia F Pyrimidine nucleoside phosphorylase C-terminal domain pdp - 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS08925 Glycos_trans_3N,Glycos_transf_3,PYNP_C k141_243_187 1286171.EAL2_c12220 6.61e-93 287.0 COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,25VD2@186806|Eubacteriaceae 186801|Clostridia M Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k141_243_188 500633.CLOHIR_01160 1.32e-78 241.0 COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,25ST0@186804|Peptostreptococcaceae 186801|Clostridia S O-methyltransferase yrrM - - - - - - - - - - - Methyltransf_3 k141_243_189 1121324.CLIT_23c04170 6.29e-202 570.0 COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,25QJC@186804|Peptostreptococcaceae 186801|Clostridia O Peptidase, U32 family yhbU_1 - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k141_243_190 457396.CSBG_01848 2.14e-96 286.0 COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,24850@186801|Clostridia,36DNP@31979|Clostridiaceae 186801|Clostridia F Cytidine monophosphokinase udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k141_113_24 1121289.JHVL01000011_gene1398 1.76e-25 114.0 COG0747@1|root,COG0747@2|Bacteria 2|Bacteria E dipeptide transport dppA - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - C5-epim_C,SBP_bac_5 k141_113_26 394503.Ccel_0901 4.64e-07 58.2 COG3858@1|root,COG3858@2|Bacteria,1UJN3@1239|Firmicutes,25F62@186801|Clostridia,36UXG@31979|Clostridiaceae 186801|Clostridia S PFAM copper amine oxidase - - - - - - - - - - - - Cu_amine_oxidN1 k141_113_27 632245.CLP_3857 5.62e-240 697.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,36DXT@31979|Clostridiaceae 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k141_113_29 35841.BT1A1_1169 2.99e-137 410.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,4H9TI@91061|Bacilli,1ZBG7@1386|Bacillus 91061|Bacilli I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0032502,GO:0043934,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k141_113_30 935836.JAEL01000165_gene2233 3.38e-50 172.0 COG4326@1|root,COG4326@2|Bacteria,1TPEA@1239|Firmicutes,4HBPW@91061|Bacilli,1ZBFU@1386|Bacillus 91061|Bacilli S COG4326 Sporulation control protein spo0M - - ko:K06377 - - - - ko00000 - - - Spo0M k141_113_31 1195246.AGRI_08940 7.75e-15 84.7 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4664E@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF EAL domain-containing protein - - - - - - - - - - - - EAL,GAF,GGDEF,PAS_9 k141_203_24 397290.C810_03943 4.21e-10 64.7 COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,27KK4@186928|unclassified Lachnospiraceae 186801|Clostridia S Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins ribU - - - - - - - - - - - ECF_trnsprt k141_203_25 373903.Hore_07490 1.69e-53 175.0 COG4250@1|root,COG4250@2|Bacteria,1V5NN@1239|Firmicutes,24I62@186801|Clostridia,3WBME@53433|Halanaerobiales 186801|Clostridia T Sensory domain in DIguanylate Cyclases and Two-component system - - - - - - - - - - - - DICT k141_203_26 1321778.HMPREF1982_01537 9.64e-47 166.0 COG1396@1|root,COG5012@1|root,COG1396@2|Bacteria,COG5012@2|Bacteria,1V5B3@1239|Firmicutes,25BRN@186801|Clostridia 186801|Clostridia K B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2,HTH_3 k141_203_27 1511.CLOST_0381 4.44e-120 349.0 COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,25TE3@186804|Peptostreptococcaceae 186801|Clostridia F Phosphorylase superfamily - - 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k141_203_28 1511.CLOST_0380 2.75e-175 504.0 COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,25RJ2@186804|Peptostreptococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k141_203_29 1121324.CLIT_11c00180 2.55e-143 412.0 COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,25R77@186804|Peptostreptococcaceae 186801|Clostridia S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k141_203_30 1511.CLOST_0377 4e-192 540.0 COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,25QBZ@186804|Peptostreptococcaceae 186801|Clostridia S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k141_203_31 1511.CLOST_0376 4.19e-283 783.0 COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,25QC2@186804|Peptostreptococcaceae 186801|Clostridia S ABC transporter - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k141_203_32 1511.CLOST_0375 7.14e-177 500.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,25S1Q@186804|Peptostreptococcaceae 186801|Clostridia S ABC transporter substrate-binding protein PnrA-like - - - ko:K07335 - - - - ko00000 - - - Bmp k141_203_33 1511.CLOST_0374 1.7e-113 330.0 COG0664@1|root,COG0664@2|Bacteria,1V5GJ@1239|Firmicutes,24GKP@186801|Clostridia,25U8N@186804|Peptostreptococcaceae 186801|Clostridia K Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k141_203_34 1453501.JELR01000002_gene723 1.02e-19 87.0 29R72@1|root,30C8E@2|Bacteria,1RE0P@1224|Proteobacteria,1S53D@1236|Gammaproteobacteria,46AQE@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k141_203_35 386415.NT01CX_0307 1.42e-224 628.0 COG2391@1|root,COG2391@2|Bacteria,1TSNG@1239|Firmicutes,25DZC@186801|Clostridia,36FZZ@31979|Clostridiaceae 186801|Clostridia S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k141_203_36 386415.NT01CX_0308 1.18e-312 863.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae 186801|Clostridia P Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k141_203_37 1443125.Z962_06870 1.93e-127 372.0 COG0583@1|root,COG0583@2|Bacteria,1TTB2@1239|Firmicutes,24CIK@186801|Clostridia,36GEG@31979|Clostridiaceae 186801|Clostridia K LysR family - - - ko:K21755 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k141_203_39 318464.IO99_08140 6.32e-81 244.0 COG2391@1|root,COG2391@2|Bacteria,1V9KG@1239|Firmicutes,25DZD@186801|Clostridia,36I84@31979|Clostridiaceae 186801|Clostridia S YeeE YedE family protein - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k141_203_40 1304284.L21TH_2394 6.47e-20 82.4 COG0425@1|root,COG0425@2|Bacteria,1VDPY@1239|Firmicutes,24NT3@186801|Clostridia,36M28@31979|Clostridiaceae 186801|Clostridia O Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - TusA k141_203_41 318464.IO99_08150 2.44e-63 203.0 COG2391@1|root,COG2391@2|Bacteria,1TS7S@1239|Firmicutes,24CIP@186801|Clostridia,36I97@31979|Clostridiaceae 186801|Clostridia S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k141_203_42 386415.NT01CX_0309 7.7e-115 350.0 COG1115@1|root,COG1115@2|Bacteria,1VSJ9@1239|Firmicutes,24EMY@186801|Clostridia,36I60@31979|Clostridiaceae 186801|Clostridia E amino acid carrier protein - - - - - - - - - - - - Na_Ala_symp k141_203_43 335541.Swol_0927 1.27e-46 179.0 COG0840@1|root,COG3290@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,42KHD@68298|Syntrophomonadaceae 186801|Clostridia NT chemotaxis sensory transducer - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1,sCache_3_3 k141_203_44 1391647.AVSV01000036_gene882 2.85e-191 541.0 COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,36EU1@31979|Clostridiaceae 186801|Clostridia C Dehydrogenase yqhD - - ko:K08325,ko:K19955 ko00640,map00640 - R02528 RC00739 ko00000,ko00001,ko01000 - - - Fe-ADH k141_203_45 1215915.BN193_02940 8.99e-24 107.0 COG4129@1|root,COG4129@2|Bacteria,1TP2T@1239|Firmicutes,4HAWV@91061|Bacilli,1YCDX@1357|Lactococcus 91061|Bacilli S Putative aromatic acid exporter C-terminal domain yqjA - - - - - - - - - - - ArAE_1,ArAE_1_C k141_203_46 632518.Calow_2008 5.93e-12 77.8 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,42FW1@68295|Thermoanaerobacterales 186801|Clostridia NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_203_48 536227.CcarbDRAFT_4787 1.89e-116 357.0 COG0642@1|root,COG2205@2|Bacteria,1TRD2@1239|Firmicutes,247M3@186801|Clostridia,36EWQ@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_203_49 1121289.JHVL01000049_gene864 1.45e-94 282.0 COG0745@1|root,COG0745@2|Bacteria,1TT73@1239|Firmicutes,2487E@186801|Clostridia,36EGW@31979|Clostridiaceae 186801|Clostridia T response regulator - - - - - - - - - - - - Response_reg,Trans_reg_C k141_203_50 358681.BBR47_12970 3.32e-38 138.0 2BM45@1|root,32FMH@2|Bacteria,1V9CH@1239|Firmicutes,4HIZX@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k141_203_51 1121324.CLIT_10c03150 1.07e-18 92.8 COG5513@1|root,COG5513@2|Bacteria,1V52X@1239|Firmicutes,25ER6@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF3298) - - - - - - - - - - - - Cu_amine_oxidN1,DUF3298,DUF4163 k141_203_52 1304284.L21TH_1661 9.44e-57 183.0 298ZI@1|root,2ZW3A@2|Bacteria,1V7FU@1239|Firmicutes,24ID8@186801|Clostridia,36KW8@31979|Clostridiaceae 186801|Clostridia S ECF transporter, substrate-specific component - - - ko:K16788 - - - - ko00000,ko02000 2.A.88.5 - - ECF_trnsprt k141_203_53 1304284.L21TH_1659 5.04e-40 138.0 2CIJU@1|root,332RU@2|Bacteria,1VESI@1239|Firmicutes,24QR7@186801|Clostridia,36MZM@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF1893) - - - - - - - - - - - - TM1506 k141_56_5 1304284.L21TH_0825 4.98e-253 711.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,36E19@31979|Clostridiaceae 186801|Clostridia M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K02168,ko:K03451,ko:K05020 - - - - ko00000,ko02000 2.A.15,2.A.15.1.1,2.A.15.1.11,2.A.15.1.3,2.A.15.1.4 - - BCCT k141_56_6 411465.PEPMIC_00958 7.19e-22 97.1 COG1309@1|root,COG1309@2|Bacteria,1V7BK@1239|Firmicutes,24HI0@186801|Clostridia,22HZE@1570339|Peptoniphilaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family grdR - - - - - - - - - - - TetR_N k141_56_8 572544.Ilyop_1733 2.01e-154 446.0 COG0517@1|root,COG1125@1|root,COG0517@2|Bacteria,COG1125@2|Bacteria,378UF@32066|Fusobacteria 32066|Fusobacteria E ABC transporter - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran,CBS k141_56_9 37659.JNLN01000001_gene1899 2.85e-145 434.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1TQ7D@1239|Firmicutes,248A1@186801|Clostridia,36DBY@31979|Clostridiaceae 186801|Clostridia P glycine, betaine opuCC - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k141_56_10 1540257.JQMW01000011_gene2546 7.28e-61 197.0 COG1309@1|root,COG1309@2|Bacteria,1V7BK@1239|Firmicutes,24HI0@186801|Clostridia,36I31@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family grdR - - - - - - - - - - - TetR_N k141_56_11 536227.CcarbDRAFT_5424 3.34e-275 758.0 28HF7@1|root,2Z7RC@2|Bacteria,1TQET@1239|Firmicutes,249YW@186801|Clostridia,36FG0@31979|Clostridiaceae 186801|Clostridia C PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits grdI - 1.21.4.4 ko:K21578 - - - - ko00000,ko01000 - - - Gly_reductase k141_56_12 748727.CLJU_c27350 7.69e-199 560.0 COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,36DEZ@31979|Clostridiaceae 186801|Clostridia S glycine betaine sarcosine D-proline reductase family grdH - 1.21.4.4 ko:K21579 - - - - ko00000,ko01000 - - - GRDB k141_56_13 1540257.JQMW01000011_gene2549 1.68e-44 144.0 2DMJK@1|root,32RZN@2|Bacteria,1VBA0@1239|Firmicutes,24MQW@186801|Clostridia,36KIM@31979|Clostridiaceae 186801|Clostridia S glycine reductase, selenoprotein B - - - - - - - - - - - - - k141_56_14 1151292.QEW_2891 8.48e-50 160.0 COG3118@1|root,COG3118@2|Bacteria,1UHX3@1239|Firmicutes,24JPM@186801|Clostridia,25RVE@186804|Peptostreptococcaceae 186801|Clostridia O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k141_56_15 1408422.JHYF01000015_gene471 1.19e-18 77.0 2DR3E@1|root,33A02@2|Bacteria,1VKEX@1239|Firmicutes,24UH8@186801|Clostridia,36P60@31979|Clostridiaceae 186801|Clostridia S Glycine reductase complex selenoprotein A grdA - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K10670 - - - - ko00000,ko01000 - - - GRDA k141_56_16 742765.HMPREF9457_03824 4.33e-56 176.0 2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia,27VQP@189330|Dorea 186801|Clostridia C COG NOG11771 non supervised orthologous group grdA - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K10670 - - - - ko00000,ko01000 - - - GRDA k141_206_3 457424.BFAG_00639 8.83e-23 99.0 COG0370@1|root,COG1918@1|root,COG0370@2|Bacteria,COG1918@2|Bacteria,4NEII@976|Bacteroidetes,2FNKT@200643|Bacteroidia,4AKWP@815|Bacteroidaceae 976|Bacteroidetes P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k141_58_1 1305737.JAFX01000001_gene1687 1.29e-16 84.7 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,4NEXU@976|Bacteroidetes,47JQC@768503|Cytophagia 976|Bacteroidetes DM TIGRFAM capsular exopolysaccharide family wzc - - - - - - - - - - - AAA_31,GNVR,Wzz k141_128_2 573061.Clocel_1182 1.84e-08 62.8 COG4733@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5492@2|Bacteria,1VJUU@1239|Firmicutes,24FQ2@186801|Clostridia,36H9Q@31979|Clostridiaceae 186801|Clostridia N antibiotic catabolic process - - - - - - - - - - - - Big_2,DUF11,DUF5057 k141_128_3 748727.CLJU_c31480 1.01e-31 135.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_128_4 1410653.JHVC01000032_gene1037 1.46e-72 239.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_128_5 1410653.JHVC01000032_gene1037 1.77e-47 178.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_128_6 1415774.U728_2127 4.93e-88 269.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,36FRF@31979|Clostridiaceae 186801|Clostridia E Histidinol phosphate phosphatase, HisJ family - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP k141_128_8 317025.Tcr_1143 1.3e-76 258.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T3X6@1236|Gammaproteobacteria,462E3@72273|Thiotrichales 72273|Thiotrichales T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - GGDEF,dCache_3 k141_128_9 1121324.CLIT_5c01230 2.17e-198 566.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,25QSF@186804|Peptostreptococcaceae 186801|Clostridia K Alanine-glyoxylate amino-transferase - - - - - - - - - - - - Aminotran_1_2,GntR k141_128_10 913848.AELK01000061_gene2255 4.37e-06 46.6 COG4224@1|root,COG4224@2|Bacteria,1VEKJ@1239|Firmicutes,4HNIB@91061|Bacilli,3F87S@33958|Lactobacillaceae 91061|Bacilli S UPF0291 protein ynzC - - - - - - - - - - - DUF896 k141_128_11 1121324.CLIT_5c01250 3.89e-60 190.0 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,249QN@186801|Clostridia,25UF5@186804|Peptostreptococcaceae 186801|Clostridia NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k141_128_12 1121324.CLIT_5c01260 8.47e-141 412.0 COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia,25SMP@186804|Peptostreptococcaceae 186801|Clostridia T Histidine kinase degS - 2.7.13.3 ko:K07777 ko02020,map02020 M00478 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DegS,HATPase_c,HisKA_3 k141_128_13 1121324.CLIT_5c01270 9.08e-108 315.0 COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,25TCI@186804|Peptostreptococcaceae 186801|Clostridia K helix_turn_helix, Lux Regulon degU - - - - - - - - - - - GerE,Response_reg k141_128_14 1304284.L21TH_1105 8.8e-167 489.0 COG1315@1|root,COG1315@2|Bacteria,1TR7W@1239|Firmicutes,24D54@186801|Clostridia,36F9H@31979|Clostridiaceae 186801|Clostridia L Pfam:DUF342 - - - ko:K09749 - - - - ko00000 - - - FapA k141_128_15 1121324.CLIT_5c01290 1.28e-82 258.0 COG0583@1|root,COG0583@2|Bacteria,1TSNI@1239|Firmicutes,249QS@186801|Clostridia 186801|Clostridia K lysR substrate binding domain protein - - - - - - - - - - - - HTH_1,LysR_substrate k141_128_16 1121324.CLIT_5c01300 1.22e-278 800.0 COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,25QIB@186804|Peptostreptococcaceae 186801|Clostridia M penicillin-binding protein mrcB - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k141_128_17 1286171.EAL2_c09910 5.99e-189 538.0 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,25V8Z@186806|Eubacteriaceae 186801|Clostridia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k141_128_18 445973.CLOBAR_01217 1.87e-48 166.0 COG1413@1|root,COG1413@2|Bacteria,1V61C@1239|Firmicutes,24FZ1@186801|Clostridia,25REB@186804|Peptostreptococcaceae 186801|Clostridia C HEAT repeats - - - - - - - - - - - - HEAT_2,HEAT_PBS,HTH_40 k141_128_19 386415.NT01CX_0729 6.2e-120 357.0 COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae 186801|Clostridia E Aminotransferase - - - - - - - - - - - - Aminotran_5 k141_128_20 1121289.JHVL01000002_gene2387 3.67e-114 348.0 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,36DCU@31979|Clostridiaceae 186801|Clostridia EH D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k141_119_24 1476973.JMMB01000007_gene2651 3.26e-179 502.0 COG0752@1|root,COG0752@2|Bacteria,1TPW8@1239|Firmicutes,24AU0@186801|Clostridia,25R89@186804|Peptostreptococcaceae 186801|Clostridia J Glycyl-tRNA synthetase alpha glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k141_119_25 1121324.CLIT_11c01200 4.23e-51 169.0 COG1308@1|root,COG1308@2|Bacteria,1V7I9@1239|Firmicutes,24M6Q@186801|Clostridia,25RXG@186804|Peptostreptococcaceae 186801|Clostridia K Domain of unknown function (DUF4342) - - - - - - - - - - - - DUF4342 k141_119_26 1476973.JMMB01000007_gene2653 3.96e-62 202.0 COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,25R8U@186804|Peptostreptococcaceae 186801|Clostridia L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k141_119_27 1286171.EAL2_c14250 8.64e-168 487.0 COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,25VPU@186806|Eubacteriaceae 186801|Clostridia P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k141_119_28 1219626.HMPREF1639_00725 1.69e-148 425.0 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,25QEP@186804|Peptostreptococcaceae 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k141_119_29 857293.CAAU_0509 3.23e-62 193.0 COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,36JJ5@31979|Clostridiaceae 186801|Clostridia F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k141_119_30 926561.KB900617_gene1765 3.66e-50 168.0 COG2928@1|root,COG2928@2|Bacteria,1V6FM@1239|Firmicutes,24JQ1@186801|Clostridia,3WBT4@53433|Halanaerobiales 186801|Clostridia S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k141_119_31 1511.CLOST_1776 9.81e-50 169.0 COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,25QEG@186804|Peptostreptococcaceae 186801|Clostridia IM Prokaryotic diacylglycerol kinase dgkA - 2.7.1.107,2.7.1.66 ko:K00887,ko:K00901 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240,R05626 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar,PAP2 k141_119_32 1476973.JMMB01000007_gene2658 1.89e-62 196.0 COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,25RAP@186804|Peptostreptococcaceae 186801|Clostridia S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - 3.5.4.5 ko:K01489,ko:K07042 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000,ko03009 - - - UPF0054 k141_119_33 1286171.EAL2_c14300 2.84e-134 391.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,25V1W@186806|Eubacteriaceae 186801|Clostridia T phosphate starvation-inducible protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH k141_119_34 1476973.JMMB01000007_gene1007 2.8e-14 71.6 2E3FE@1|root,32YE8@2|Bacteria,1VFR0@1239|Firmicutes,24SIH@186801|Clostridia,25RW2@186804|Peptostreptococcaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_119_35 1511.CLOST_1587 3.29e-108 314.0 COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,25QK1@186804|Peptostreptococcaceae 186801|Clostridia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k141_191_1 1121324.CLIT_23c01320 1.02e-193 549.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24AN3@186801|Clostridia,25SKE@186804|Peptostreptococcaceae 186801|Clostridia C electron transport complex protein RnfC K03615 prdC - - - - - - - - - - - Complex1_51K,RnfC_N k141_191_2 1121324.CLIT_23c01330 0.0 929.0 COG0252@1|root,COG5275@1|root,COG0252@2|Bacteria,COG5275@2|Bacteria,1TQ9S@1239|Firmicutes,24A9Y@186801|Clostridia,25SZX@186804|Peptostreptococcaceae 186801|Clostridia EJ D-proline reductase prdA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0046992,GO:0050002,GO:0050485,GO:0055114 1.21.4.1 ko:K10793 ko00330,map00330 - R02825 RC00790 ko00000,ko00001,ko01000 - - - Gly_reductase k141_191_3 1121324.CLIT_23c01340 4.26e-44 144.0 2BWPJ@1|root,32YWH@2|Bacteria,1VFE6@1239|Firmicutes,24QJI@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_191_4 1121324.CLIT_23c01350 6.44e-154 434.0 COG1978@1|root,COG1978@2|Bacteria,1UYNY@1239|Firmicutes,24G4U@186801|Clostridia,25S4M@186804|Peptostreptococcaceae 186801|Clostridia S Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) prdB - 1.21.4.1 ko:K10794 ko00330,map00330 - R02825 RC00790 ko00000,ko00001,ko01000 - - - GRDB k141_191_5 1121324.CLIT_23c01450 5.33e-105 311.0 COG5275@1|root,COG5275@2|Bacteria,1UZHN@1239|Firmicutes,24C77@186801|Clostridia,25SC9@186804|Peptostreptococcaceae 186801|Clostridia S Glycine/sarcosine/betaine reductase component B subunits prdD - 1.21.4.1 ko:K10793,ko:K10795 ko00330,map00330 - R02825 RC00790 ko00000,ko00001,ko01000 - - - Gly_reductase k141_191_6 1121324.CLIT_23c01370 2.55e-87 259.0 COG0252@1|root,COG0252@2|Bacteria,1V5HP@1239|Firmicutes,24GD5@186801|Clostridia 186801|Clostridia EJ reductase prdE - - ko:K10796 - - - - ko00000 - - - Gly_reductase k141_191_7 1476973.JMMB01000007_gene2692 7.85e-195 545.0 COG3938@1|root,COG3938@2|Bacteria,1TQ61@1239|Firmicutes,2487S@186801|Clostridia,25SMF@186804|Peptostreptococcaceae 186801|Clostridia E Proline racemase prdF - 5.1.1.4 ko:K01777 ko00330,ko01100,map00330,map01100 - R01255 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase k141_191_8 1121324.CLIT_23c01390 4.42e-132 383.0 COG0730@1|root,COG0730@2|Bacteria,1TQ8H@1239|Firmicutes,24BA5@186801|Clostridia 186801|Clostridia S membrane transporter protein - - - - - - - - - - - - TauE k141_191_9 1121324.CLIT_23c01490 1.39e-62 199.0 COG0500@1|root,COG2226@2|Bacteria,1VK9C@1239|Firmicutes,24RPV@186801|Clostridia 186801|Clostridia Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k141_191_10 1391646.AVSU01000037_gene2094 7.89e-197 571.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,25QR6@186804|Peptostreptococcaceae 186801|Clostridia K Sigma-54 interaction domain protein ygeV - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat,SpoVT_C k141_191_11 1408422.JHYF01000009_gene2020 3.15e-93 276.0 COG0634@1|root,COG0634@2|Bacteria,1V2K7@1239|Firmicutes,248P7@186801|Clostridia,36F2B@31979|Clostridiaceae 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16720 Pribosyltran k141_191_12 702450.CUW_1344 1.47e-67 215.0 COG2171@1|root,COG2171@2|Bacteria,1TQUJ@1239|Firmicutes,3VPZK@526524|Erysipelotrichia 526524|Erysipelotrichia E Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate dapD - - - - - - - - - - - DapH_N,Hexapep k141_243_337 1487921.DP68_01460 2.15e-26 106.0 COG1309@1|root,COG1309@2|Bacteria,1VF0Y@1239|Firmicutes,24N8C@186801|Clostridia,36M7G@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k141_243_338 1121324.CLIT_2c03390 1.49e-284 807.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,25SH8@186804|Peptostreptococcaceae 186801|Clostridia O C-terminal, D2-small domain, of ClpB protein - - - ko:K03697 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small k141_243_339 1121324.CLIT_14c00130 1.26e-99 294.0 COG1584@1|root,COG1584@2|Bacteria,1TSYX@1239|Firmicutes,249E0@186801|Clostridia,25QW0@186804|Peptostreptococcaceae 186801|Clostridia S GPR1/FUN34/yaaH family yaaH - - ko:K07034 - - - - ko00000 - - - Grp1_Fun34_YaaH k141_243_340 1230342.CTM_19949 4.24e-98 296.0 COG2197@1|root,COG2197@2|Bacteria,1UHXC@1239|Firmicutes,24BCY@186801|Clostridia,36F4X@31979|Clostridiaceae 186801|Clostridia T response regulator - - - - - - - - - - - - CheX,Response_reg k141_243_341 1410653.JHVC01000019_gene2182 9.58e-63 196.0 COG1406@1|root,COG1406@2|Bacteria,1VD18@1239|Firmicutes,24HMR@186801|Clostridia,36ING@31979|Clostridiaceae 186801|Clostridia N Chemotaxis protein CheX cheX - - ko:K03409 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheX k141_243_342 457570.Nther_0831 1.13e-42 145.0 2C91C@1|root,30CC5@2|Bacteria,1V1Z2@1239|Firmicutes,24HJH@186801|Clostridia 186801|Clostridia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C k141_243_343 1501230.ET33_11590 6.25e-49 171.0 COG3711@1|root,COG3711@2|Bacteria,1TQJJ@1239|Firmicutes,4HBB3@91061|Bacilli,26SX5@186822|Paenibacillaceae 91061|Bacilli K antiterminator glcT - - ko:K03480 - - - - ko00000,ko03000 - - - CAT_RBD,PRD k141_243_344 994573.T472_0208165 4e-300 839.0 COG1263@1|root,COG2190@1|root,COG1263@2|Bacteria,COG2190@2|Bacteria,1TPJ8@1239|Firmicutes,24809@186801|Clostridia,36DWW@31979|Clostridiaceae 186801|Clostridia G Pts system - - 2.7.1.199 ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00809 R02738 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.9 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k141_243_345 1286171.EAL2_c06990 3.57e-116 344.0 COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,247Q4@186801|Clostridia,25X37@186806|Eubacteriaceae 186801|Clostridia EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k141_243_346 1121324.CLIT_5c00430 1.21e-193 567.0 COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,25QER@186804|Peptostreptococcaceae 186801|Clostridia G Alpha-amylase domain apu - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Alpha-amylase,Glyco_hydro_77,Malt_amylase_C k141_243_347 1304284.L21TH_1975 9.4e-211 605.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat k141_243_348 1121324.CLIT_17c00160 1.14e-109 326.0 COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,248I1@186801|Clostridia,25SDF@186804|Peptostreptococcaceae 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA k141_243_349 536227.CcarbDRAFT_2632 1.83e-33 118.0 COG0011@1|root,COG0011@2|Bacteria,1VBWM@1239|Firmicutes,25DPD@186801|Clostridia,36UDS@31979|Clostridiaceae 186801|Clostridia S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k141_243_350 1391647.AVSV01000036_gene854 1.77e-76 248.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,36DJS@31979|Clostridiaceae 186801|Clostridia H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k141_243_351 1540257.JQMW01000011_gene2227 2.83e-56 185.0 COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,36GCB@31979|Clostridiaceae 186801|Clostridia H riboflavin synthase, alpha subunit ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k141_243_352 1294142.CINTURNW_4361 1.09e-123 370.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,36E7D@31979|Clostridiaceae 186801|Clostridia H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10830 DHBP_synthase,GTP_cyclohydro2 k141_243_353 1345695.CLSA_c14650 3.18e-68 210.0 COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,36HYD@31979|Clostridiaceae 186801|Clostridia H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k141_243_354 1123405.AUMM01000012_gene2279 2.77e-36 127.0 COG1098@1|root,COG1098@2|Bacteria,1VASQ@1239|Firmicutes,4HKSW@91061|Bacilli,26PUB@186821|Sporolactobacillaceae 91061|Bacilli J Ribosomal protein S1-like RNA-binding domain yugI - - ko:K07570,ko:K07571 - - - - ko00000 - - - S1 k141_243_355 1286171.EAL2_c16660 4.15e-232 660.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,25V8F@186806|Eubacteriaceae 186801|Clostridia C Na H antiporter - - - - - - - - - - - - Na_H_antiporter k141_243_356 1128398.Curi_c06150 0.0 1627.0 COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,267XD@186813|unclassified Clostridiales 186801|Clostridia J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k141_243_357 697303.Thewi_1100 5.09e-57 186.0 COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,24HGD@186801|Clostridia,42F34@68295|Thermoanaerobacterales 186801|Clostridia S cyclase family - - 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase k141_243_358 1121324.CLIT_23c00650 1.7e-115 355.0 COG0364@1|root,COG0364@2|Bacteria,1TPYF@1239|Firmicutes,24939@186801|Clostridia 186801|Clostridia G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k141_243_359 697303.Thewi_1098 1.42e-116 344.0 COG1023@1|root,COG1023@2|Bacteria,1UHN4@1239|Firmicutes,25E7N@186801|Clostridia,42EW4@68295|Thermoanaerobacterales 186801|Clostridia C TIGRFAM 6-phosphogluconate dehydrogenase gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k141_243_360 1121324.CLIT_23c04760 6.55e-119 355.0 COG0726@1|root,COG0726@2|Bacteria,1TRUR@1239|Firmicutes,24D1N@186801|Clostridia 186801|Clostridia G PFAM Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k141_243_361 1286171.EAL2_c09410 1.68e-159 458.0 COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,25VI7@186806|Eubacteriaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - NMO k141_243_362 572544.Ilyop_0596 3.78e-180 514.0 COG2195@1|root,COG2195@2|Bacteria,3783C@32066|Fusobacteria 32066|Fusobacteria E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M42 k141_243_363 986075.CathTA2_0248 4.68e-18 78.6 COG3326@1|root,COG3326@2|Bacteria 2|Bacteria L Membrane ysdA - - - - - - - - - - - CSD,DUF1294 k141_243_364 709032.Sulku_1324 5.68e-07 57.8 COG2199@1|root,COG3706@2|Bacteria,1NY4T@1224|Proteobacteria,42YUI@68525|delta/epsilon subdivisions,2YR50@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GGDEF k141_243_365 1121324.CLIT_5c00690 4.2e-168 483.0 COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia 186801|Clostridia P Transporter, CPA2 family - - - - - - - - - - - - Na_H_Exchanger k141_243_366 1304284.L21TH_1716 1.27e-38 133.0 COG0347@1|root,COG0347@2|Bacteria,1VFZ7@1239|Firmicutes,24N1M@186801|Clostridia,36KTI@31979|Clostridiaceae 186801|Clostridia E Belongs to the P(II) protein family - - - - - - - - - - - - - k141_243_367 868595.Desca_2263 8.69e-81 244.0 COG0622@1|root,COG0622@2|Bacteria,1V1X1@1239|Firmicutes,24GA4@186801|Clostridia,262HX@186807|Peptococcaceae 186801|Clostridia S Calcineurin-like phosphoesterase superfamily domain yfcE - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k141_243_368 293826.Amet_3174 2.65e-110 326.0 COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,36EBN@31979|Clostridiaceae 186801|Clostridia H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05480 NAD_kinase k141_243_369 1121864.OMO_01296 1.77e-10 62.8 COG0110@1|root,COG1605@1|root,COG0110@2|Bacteria,COG1605@2|Bacteria,1TQEX@1239|Firmicutes,4HAJ0@91061|Bacilli,4B0HP@81852|Enterococcaceae 91061|Bacilli E Maltose acetyltransferase maa - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - CM_2,Hexapep,Hexapep_2,Mac k141_243_370 445973.CLOBAR_00817 1.82e-91 281.0 COG0564@1|root,COG0564@2|Bacteria,1TS0P@1239|Firmicutes,25CCQ@186801|Clostridia,25UMC@186804|Peptostreptococcaceae 186801|Clostridia G Responsible for synthesis of pseudouridine from uracil - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k141_243_371 500633.CLOHIR_01140 4.85e-13 65.1 COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes 1239|Firmicutes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k141_243_372 1382305.AZUC01000063_gene3240 4.45e-51 171.0 COG0220@1|root,COG0220@2|Bacteria,1TQCA@1239|Firmicutes,4HC08@91061|Bacilli,26D7P@186818|Planococcaceae 91061|Bacilli J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k141_243_373 1286171.EAL2_c09550 5.05e-145 419.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,25WGG@186806|Eubacteriaceae 186801|Clostridia K helix_turn _helix lactose operon repressor ccpA - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k141_243_374 1511.CLOST_2105 0.0 1062.0 COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia 186801|Clostridia O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k141_243_375 272563.CD630_07910 1.68e-102 302.0 COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,25QJ6@186804|Peptostreptococcaceae 186801|Clostridia S Psort location Cytoplasmic, score yvyE - - - - - - - - - - - DUF1949,UPF0029 k141_243_376 350688.Clos_1782 1.25e-43 146.0 COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,36UCP@31979|Clostridiaceae 186801|Clostridia S CoA-binding domain protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k141_243_377 1121289.JHVL01000010_gene1354 2.51e-116 344.0 COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,36EXG@31979|Clostridiaceae 186801|Clostridia Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - FAA_hydrolase k141_243_378 1121324.CLIT_23c02770 1.77e-139 409.0 COG2865@1|root,COG2865@2|Bacteria,1UZZK@1239|Firmicutes,25CHX@186801|Clostridia 186801|Clostridia K PFAM AAA-4 family protein - - - - - - - - - - - - AlbA_2 k141_243_379 445973.CLOBAR_02789 1.99e-183 525.0 COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,25SXA@186804|Peptostreptococcaceae 186801|Clostridia C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 k141_243_380 596329.HMPREF0631_1838 2.57e-215 606.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,25R13@186804|Peptostreptococcaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k141_243_381 272563.CD630_26300 1.69e-137 400.0 COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia,25QDE@186804|Peptostreptococcaceae 186801|Clostridia I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k141_243_382 1511.CLOST_1882 4.65e-35 140.0 COG0845@1|root,COG0845@2|Bacteria,1UECZ@1239|Firmicutes,25J8Z@186801|Clostridia,25RI9@186804|Peptostreptococcaceae 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - k141_243_383 1286171.EAL2_c14910 1.23e-78 243.0 COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,25VJK@186806|Eubacteriaceae 186801|Clostridia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k141_243_384 1121324.CLIT_23c02820 1.23e-54 176.0 COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,25RRB@186804|Peptostreptococcaceae 186801|Clostridia D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA sepF - - ko:K09772 - - - - ko00000,ko03036 - - - SepF k141_243_385 1095747.HMPREF1049_0435 7.33e-06 47.8 COG0762@1|root,COG0762@2|Bacteria,37B79@32066|Fusobacteria 32066|Fusobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k141_243_386 1286171.EAL2_c14880 6.11e-56 187.0 COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia,25WBN@186806|Eubacteriaceae 186801|Clostridia S S4 domain protein - - - - - - - - - - - - S4 k141_243_387 350688.Clos_1411 1.5e-35 127.0 COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia,36FZ8@31979|Clostridiaceae 186801|Clostridia D PFAM DivIVA family protein divIVA - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA k141_243_388 1151292.QEW_3150 1.59e-87 265.0 COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,247U5@186801|Clostridia,25QGK@186804|Peptostreptococcaceae 186801|Clostridia E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively mtnN - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k141_243_389 1121324.CLIT_23c02870 8.05e-55 176.0 COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,25RJB@186804|Peptostreptococcaceae 186801|Clostridia MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k141_243_390 500633.CLOHIR_01118 8.42e-128 373.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,25QI5@186804|Peptostreptococcaceae 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k141_243_391 293826.Amet_2795 8.5e-78 236.0 COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,36I1Q@31979|Clostridiaceae 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - iHN637.CLJU_RS05275 Pribosyltran k141_186_23 1158607.UAU_02227 2.14e-09 62.8 COG1309@1|root,COG1309@2|Bacteria,1TWE4@1239|Firmicutes,4I43W@91061|Bacilli,4B1WK@81852|Enterococcaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k141_186_24 386415.NT01CX_1548 2.54e-37 147.0 COG0845@1|root,COG0845@2|Bacteria,1V3TH@1239|Firmicutes,24AAF@186801|Clostridia,36FC9@31979|Clostridiaceae 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k141_186_25 1121324.CLIT_10c05110 0.0 1006.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,25QT4@186804|Peptostreptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG2 - - - - - - - - - - - ACR_tran k141_186_26 985665.HPL003_18205 1.4e-39 135.0 COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,4ISDB@91061|Bacilli,26XDQ@186822|Paenibacillaceae 91061|Bacilli T Chemotaxis protein CheY cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k141_186_27 1499683.CCFF01000015_gene3522 3.84e-77 236.0 COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,36FPJ@31979|Clostridiaceae 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k141_186_28 1476973.JMMB01000007_gene430 1.57e-138 400.0 COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,25QCB@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the conversion of dihydroorotate to orotate pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k141_186_29 478749.BRYFOR_05308 5.37e-67 214.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - iHN637.CLJU_RS17580 DHODB_Fe-S_bind,NAD_binding_1 k141_186_30 1033737.CAEV01000043_gene1457 1.87e-96 292.0 COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,36E3E@31979|Clostridiaceae 186801|Clostridia F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17585 OMPdecase k141_186_31 1123009.AUID01000034_gene1215 6.63e-107 327.0 COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,267UG@186813|unclassified Clostridiales 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k141_186_32 536232.CLM_3652 1.21e-48 160.0 COG1781@1|root,COG1781@2|Bacteria,1V6U9@1239|Firmicutes,24JJU@186801|Clostridia,36JII@31979|Clostridiaceae 186801|Clostridia F aspartate carbamoyltransferase, regulatory pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C k141_186_33 857293.CAAU_1392 2.74e-156 446.0 COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,36DT0@31979|Clostridiaceae 186801|Clostridia F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N,PyrI_C k141_186_35 1304284.L21TH_1824 1.39e-283 779.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae 186801|Clostridia E Belongs to the Glu Leu Phe Val dehydrogenases family gdh GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0071704,GO:1901564 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k141_186_36 1121324.CLIT_20c00210 2.64e-76 240.0 COG1302@1|root,COG1302@2|Bacteria,1V1TU@1239|Firmicutes,24E60@186801|Clostridia 186801|Clostridia F Psort location Cytoplasmic, score - - - - - - - - - - - - Asp23,IPT k141_186_37 1304284.L21TH_0868 2.32e-14 67.0 COG2768@1|root,COG2768@2|Bacteria,1VET2@1239|Firmicutes,24QUH@186801|Clostridia,36MIM@31979|Clostridiaceae 186801|Clostridia C Ferredoxin fdxA GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 - - - - - - - - - - Fer4 k141_186_38 1121324.CLIT_20c00190 1.86e-108 318.0 COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,25R18@186804|Peptostreptococcaceae 186801|Clostridia K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N k141_186_39 1151292.QEW_0191 1.28e-241 689.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,25R5G@186804|Peptostreptococcaceae 186801|Clostridia S ABC transporter, ATP-binding protein - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k141_186_40 1301100.HG529422_gene4234 6.98e-179 505.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,36DHM@31979|Clostridiaceae 186801|Clostridia J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k141_186_41 1280689.AUJC01000001_gene2348 5.63e-41 140.0 COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,36JIM@31979|Clostridiaceae 186801|Clostridia K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 k141_186_42 500633.CLOHIR_00037 1.63e-62 202.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,25QHX@186804|Peptostreptococcaceae 186801|Clostridia O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 k141_186_43 272563.CD630_01490 9.28e-67 206.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,25RB4@186804|Peptostreptococcaceae 186801|Clostridia S Threonylcarbamoyl adenosine biosynthesis protein TsaE ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k141_186_44 1121324.CLIT_20c00130 2.62e-73 227.0 COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,25T8Q@186804|Peptostreptococcaceae 186801|Clostridia U Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins ribU - - - - - - - - - - - ECF_trnsprt k141_186_45 1304284.L21TH_1551 1.87e-180 513.0 COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae 186801|Clostridia Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k141_186_46 1151292.QEW_0169 1.07e-300 845.0 COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,25QRG@186804|Peptostreptococcaceae 186801|Clostridia K Tex-like protein yhgF - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k141_186_47 293826.Amet_0796 1.43e-09 60.1 COG1516@1|root,COG1516@2|Bacteria,1VGUR@1239|Firmicutes,24QV2@186801|Clostridia,36MM8@31979|Clostridiaceae 186801|Clostridia N Flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k141_186_48 1121324.CLIT_20c00090 3.17e-226 642.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella hag - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_186_49 1410630.JNKP01000004_gene475 4.71e-09 59.7 COG1516@1|root,COG1516@2|Bacteria,1VD1Q@1239|Firmicutes,24PMH@186801|Clostridia,27P09@186928|unclassified Lachnospiraceae 186801|Clostridia NOU Flagellar protein FliS - - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k141_186_50 1121324.CLIT_20c00090 2.66e-215 615.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella hag - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_186_51 350688.Clos_2480 1.55e-21 87.8 COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia,36NNP@31979|Clostridiaceae 186801|Clostridia N cytoplasmic domain of flagellar protein FhlB flhB1 - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 k141_186_52 1511.CLOST_2308 6.6e-43 178.0 COG1196@1|root,COG1196@2|Bacteria,1V4Z9@1239|Firmicutes,24I4M@186801|Clostridia,25SCR@186804|Peptostreptococcaceae 186801|Clostridia D nuclear chromosome segregation - - - - - - - - - - - - - k141_186_53 1286171.EAL2_c17730 4.94e-48 159.0 COG1728@1|root,COG1728@2|Bacteria,1VF6M@1239|Firmicutes,24S6C@186801|Clostridia,25WM8@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF327) - - - ko:K09770 - - - - ko00000 - - - DUF327 k141_186_54 1391646.AVSU01000017_gene3113 4.99e-156 448.0 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,25QGI@186804|Peptostreptococcaceae 186801|Clostridia J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k141_186_55 1286171.EAL2_c17750 0.0 1241.0 COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,25VEZ@186806|Eubacteriaceae 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k141_186_56 97138.C820_00928 6.95e-83 278.0 COG3210@1|root,COG3210@2|Bacteria,1V182@1239|Firmicutes,24BHJ@186801|Clostridia 186801|Clostridia U domain, Protein - - - - - - - - - - - - - k141_186_57 1122917.KB899681_gene374 7.42e-37 155.0 COG3391@1|root,COG4385@1|root,COG3391@2|Bacteria,COG4385@2|Bacteria,1UZ1H@1239|Firmicutes,4HAFG@91061|Bacilli,26UC4@186822|Paenibacillaceae 91061|Bacilli S Phage tail protein (Tail_P2_I) - - - - - - - - - - - - Tail_P2_I k141_186_58 1122917.KB899681_gene375 1.64e-39 164.0 COG3299@1|root,COG3299@2|Bacteria,1UH8J@1239|Firmicutes,4HF47@91061|Bacilli,26U3S@186822|Paenibacillaceae 91061|Bacilli S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k141_186_59 398512.JQKC01000024_gene3230 9.11e-156 494.0 COG3299@1|root,COG3299@2|Bacteria,1TRCX@1239|Firmicutes,24BAX@186801|Clostridia,3WI91@541000|Ruminococcaceae 186801|Clostridia S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k141_186_60 1007103.AFHW01000139_gene1433 1.88e-45 151.0 COG3628@1|root,COG3628@2|Bacteria,1VCD7@1239|Firmicutes,4HKUU@91061|Bacilli,26YDR@186822|Paenibacillaceae 91061|Bacilli S Gene 25-like lysozyme - - - ko:K06903 - - - - ko00000 - - - GPW_gp25 k141_186_61 358681.BBR47_42110 2.19e-52 176.0 COG3501@1|root,COG3501@2|Bacteria,1V234@1239|Firmicutes,4HG3D@91061|Bacilli,26URM@186822|Paenibacillaceae 91061|Bacilli S Rhs element vgr protein - - - - - - - - - - - - Phage_base_V k141_186_62 1280666.ATVS01000003_gene2166 1.11e-26 117.0 COG3500@1|root,COG3500@2|Bacteria,1V27U@1239|Firmicutes,24GYN@186801|Clostridia,4BY7N@830|Butyrivibrio 186801|Clostridia S Late control gene D protein - - - - - - - - - - - - - k141_186_63 1122917.KB899681_gene380 1.26e-65 208.0 COG1652@1|root,COG1652@2|Bacteria,1V83T@1239|Firmicutes,4HJ06@91061|Bacilli,26VCS@186822|Paenibacillaceae 91061|Bacilli S LysM domain - - - - - - - - - - - - LysM k141_190_1 1304866.K413DRAFT_2047 3.32e-18 80.9 COG1683@1|root,COG1683@2|Bacteria,1V700@1239|Firmicutes,24JD2@186801|Clostridia,36JUS@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 k141_190_2 290318.Cvib_0178 6.09e-20 84.7 COG0824@1|root,COG0824@2|Bacteria,1FF3Z@1090|Chlorobi 1090|Chlorobi S PFAM thioesterase superfamily protein - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k141_190_3 1408310.JHUW01000009_gene186 7.39e-05 43.5 COG0824@1|root,COG0824@2|Bacteria,4NSJR@976|Bacteroidetes,2FS2E@200643|Bacteroidia 976|Bacteroidetes S acyl-CoA thioester hydrolase, YbgC YbaW family - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k141_208_16 1031288.AXAA01000007_gene899 1.87e-07 56.2 COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,36H8M@31979|Clostridiaceae 186801|Clostridia NOU peptidase hofD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k141_208_17 1121324.CLIT_17c00090 0.0 1760.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,25QC0@186804|Peptostreptococcaceae 186801|Clostridia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k141_208_25 865861.AZSU01000001_gene413 2.84e-133 389.0 COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,36G47@31979|Clostridiaceae 186801|Clostridia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k141_242_138 1292035.H476_1861 1.76e-91 276.0 COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,25R6Y@186804|Peptostreptococcaceae 186801|Clostridia H ThiF family - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF k141_242_139 1158612.I580_00698 4.95e-25 112.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9M4@91061|Bacilli,4AZQ0@81852|Enterococcaceae 91061|Bacilli S Competence protein comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k141_242_140 1408823.AXUS01000003_gene502 3.41e-116 343.0 COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia,25QVR@186804|Peptostreptococcaceae 186801|Clostridia S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 k141_242_141 500633.CLOHIR_02033 3.96e-85 271.0 COG4552@1|root,COG4552@2|Bacteria,1TRPM@1239|Firmicutes,24AP4@186801|Clostridia,25RCF@186804|Peptostreptococcaceae 186801|Clostridia S Sterol carrier protein domain - - - - - - - - - - - - Acetyltransf_9,SCP2_2 k141_242_142 1292035.H476_0719 1.01e-43 149.0 COG4720@1|root,COG4720@2|Bacteria,1TTCZ@1239|Firmicutes,25MT7@186801|Clostridia,25TDE@186804|Peptostreptococcaceae 186801|Clostridia S ECF-type riboflavin transporter, S component - - - - - - - - - - - - ECF-ribofla_trS k141_242_144 445973.CLOBAR_02747 2.77e-93 288.0 COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,25QPQ@186804|Peptostreptococcaceae 186801|Clostridia L DNA polymerase III, delta' subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k141_242_145 500633.CLOHIR_02037 1.84e-30 110.0 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,25RNU@186804|Peptostreptococcaceae 186801|Clostridia J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k141_242_146 546269.HMPREF0389_00026 0.0 967.0 COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,25QKW@186804|Peptostreptococcaceae 186801|Clostridia M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k141_243_4 748727.CLJU_c17440 5.49e-95 278.0 COG3449@1|root,COG3449@2|Bacteria,1V73Y@1239|Firmicutes,24HGB@186801|Clostridia,36I41@31979|Clostridiaceae 186801|Clostridia L PFAM Bacterial transcription activator, effector binding - - - - - - - - - - - - GyrI-like k141_243_5 1321784.HMPREF1987_00129 3.28e-191 551.0 COG0437@1|root,COG4624@1|root,COG0437@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,25R36@186804|Peptostreptococcaceae 186801|Clostridia C 4Fe-4S binding domain protein - - - - - - - - - - - - Fe_hyd_lg_C,Fer4,Fer4_6 k141_243_6 1410668.JNKC01000004_gene238 4.86e-18 78.6 2EKY6@1|root,33EMQ@2|Bacteria,1VNMY@1239|Firmicutes,24UJM@186801|Clostridia,36SYD@31979|Clostridiaceae 186801|Clostridia S Thioredoxin-like [2Fe-2S] ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx k141_243_7 1238182.C882_2002 3.47e-157 448.0 COG0618@1|root,COG0618@2|Bacteria,1MX0B@1224|Proteobacteria,2TWVV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S 3'(2'),5'-bisphosphate nucleotidase activity - - - - - - - - - - - - - k141_243_8 1278309.KB907105_gene1406 6.82e-45 148.0 COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,1S5WM@1236|Gammaproteobacteria,1XK86@135619|Oceanospirillales 135619|Oceanospirillales J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k141_243_10 536232.CLM_2031 7.13e-222 628.0 COG0531@1|root,COG0531@2|Bacteria,1TRFS@1239|Firmicutes,248WW@186801|Clostridia,36EQ7@31979|Clostridiaceae 186801|Clostridia E amino acid yjeM - - - - - - - - - - - AA_permease_2 k141_243_11 99598.Cal7507_0956 3.24e-08 63.9 COG1135@1|root,COG1135@2|Bacteria,1G289@1117|Cyanobacteria,1HIGB@1161|Nostocales 1117|Cyanobacteria P P-loop Domain of unknown function (DUF2791) - - - - - - - - - - - - DUF2791 k141_243_13 926561.KB900624_gene2714 1.23e-105 313.0 COG1192@1|root,COG1192@2|Bacteria,1U18X@1239|Firmicutes,24E35@186801|Clostridia,3WC9F@53433|Halanaerobiales 186801|Clostridia D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k141_243_15 580327.Tthe_1038 1.62e-40 143.0 COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia,42GQC@68295|Thermoanaerobacterales 186801|Clostridia S PFAM BioY protein bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY k141_243_16 929506.CbC4_0793 1.68e-65 210.0 COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae 186801|Clostridia K GntR domain protein - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k141_243_17 1121324.CLIT_23c03200 5.24e-222 629.0 COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,25QT6@186804|Peptostreptococcaceae 186801|Clostridia C L-lactate permease lctP - - ko:K03303 - - - - ko00000,ko02000 2.A.14 - - Lactate_perm k141_243_18 1121289.JHVL01000008_gene1238 1.97e-134 387.0 COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36FGA@31979|Clostridiaceae 186801|Clostridia C Electron transfer flavoprotein etfB1 - - ko:K03521 - - - - ko00000 - - - ETF k141_243_19 1304284.L21TH_1081 7.71e-210 589.0 COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae 186801|Clostridia C Electron transfer flavoprotein etfA2 - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k141_243_20 1476973.JMMB01000007_gene944 1.58e-261 725.0 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,25SG3@186804|Peptostreptococcaceae 186801|Clostridia C FAD linked oxidases, C-terminal domain glcD1 - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k141_243_21 1128398.Curi_c04040 9.79e-90 272.0 COG2188@1|root,COG2188@2|Bacteria,1UWXE@1239|Firmicutes,25MUS@186801|Clostridia,26C29@186813|unclassified Clostridiales 186801|Clostridia K UTRA domain - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k141_243_22 1128398.Curi_c04060 9.61e-226 634.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,267TX@186813|unclassified Clostridiales 186801|Clostridia F Amidohydrolase family atzB - - - - - - - - - - - Amidohydro_1 k141_243_23 1128398.Curi_c04050 5.96e-75 233.0 COG2364@1|root,COG2364@2|Bacteria,1V47R@1239|Firmicutes,24AXT@186801|Clostridia 186801|Clostridia S membrane - - - ko:K07149 - - - - ko00000 - - - YitT_membrane k141_243_24 1122931.AUAE01000030_gene843 5.85e-09 57.8 2EG60@1|root,339XW@2|Bacteria,4NY08@976|Bacteroidetes,2FS7K@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - Inhibitor_I42 k141_243_26 484770.UFO1_1179 3.38e-47 157.0 COG3708@1|root,COG3708@2|Bacteria,1TPI9@1239|Firmicutes 1239|Firmicutes K Transcriptional regulator ydeE7 - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 k141_243_27 536227.CcarbDRAFT_4777 1.33e-121 352.0 COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,24AK0@186801|Clostridia,36GRN@31979|Clostridiaceae 186801|Clostridia S Threonyl alanyl tRNA synthetase SAD - - - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k141_243_28 349161.Dred_0870 7.37e-260 731.0 COG0497@1|root,COG3593@1|root,COG0497@2|Bacteria,COG3593@2|Bacteria,1VCSI@1239|Firmicutes 1239|Firmicutes L AAA ATPase domain - - - - - - - - - - - - AAA_15,AAA_21,AAA_29 k141_243_29 1216932.CM240_0842 3.6e-127 385.0 COG3066@1|root,COG3066@2|Bacteria,1TS3J@1239|Firmicutes,249BA@186801|Clostridia,36H6K@31979|Clostridiaceae 186801|Clostridia L DNA mismatch repair enzyme MutH - - - - - - - - - - - - MutH k141_243_30 1216932.CM240_0841 2.11e-192 545.0 COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes,249Q9@186801|Clostridia,36GET@31979|Clostridiaceae 186801|Clostridia H PFAM C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k141_243_32 596329.HMPREF0631_1854 4.2e-179 508.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,25QQJ@186804|Peptostreptococcaceae 186801|Clostridia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k141_243_33 1121324.CLIT_11c00380 1.27e-145 427.0 COG0612@1|root,COG0612@2|Bacteria,1TPN6@1239|Firmicutes,248J8@186801|Clostridia,25R2M@186804|Peptostreptococcaceae 186801|Clostridia S Peptidase M16 inactive domain protein - - - - - - - - - - - - Peptidase_M16_C k141_243_34 1121324.CLIT_11c00390 1.01e-216 608.0 COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,25R6R@186804|Peptostreptococcaceae 186801|Clostridia S Peptidase M16 inactive domain protein ymfH - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k141_243_35 1121324.CLIT_11c00400 1.29e-121 353.0 COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,25QZI@186804|Peptostreptococcaceae 186801|Clostridia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k141_243_36 1121324.CLIT_11c00410 8.64e-168 475.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,25QND@186804|Peptostreptococcaceae 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k141_243_37 1121289.JHVL01000030_gene402 8.28e-09 58.2 2FKXC@1|root,34CHK@2|Bacteria,1VIXH@1239|Firmicutes,24TRI@186801|Clostridia 186801|Clostridia S Septum formation initiator - - - - - - - - - - - - DivIC k141_243_38 1286171.EAL2_c10420 5.28e-231 669.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,25V2F@186806|Eubacteriaceae 186801|Clostridia M Penicillin-binding protein, transpeptidase domain protein spoVD - 3.4.16.4 ko:K03587,ko:K08384 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k141_243_39 1304284.L21TH_0611 5.35e-135 406.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,36DF8@31979|Clostridiaceae 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k141_243_40 1476973.JMMB01000007_gene857 1.34e-151 446.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,25QJG@186804|Peptostreptococcaceae 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k141_243_41 1286171.EAL2_c10450 2.85e-104 315.0 COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,25V83@186806|Eubacteriaceae 186801|Clostridia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k141_243_42 1391646.AVSU01000092_gene398 2.59e-156 457.0 COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,25QXT@186804|Peptostreptococcaceae 186801|Clostridia M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k141_243_43 1408823.AXUS01000018_gene3097 3.85e-120 361.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,25QJI@186804|Peptostreptococcaceae 186801|Clostridia D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k141_243_44 596329.HMPREF0631_1844 5.39e-111 335.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,25R4M@186804|Peptostreptococcaceae 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k141_243_45 1121324.CLIT_11c00500 1.16e-55 186.0 COG1589@1|root,COG1589@2|Bacteria,1VEMW@1239|Firmicutes,24QKM@186801|Clostridia 186801|Clostridia D Cell division protein FtsQ ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k141_243_46 1121324.CLIT_11c00510 1.61e-72 228.0 COG3879@1|root,COG3879@2|Bacteria,1V66C@1239|Firmicutes,2492Y@186801|Clostridia,25TEP@186804|Peptostreptococcaceae 186801|Clostridia S Bacterial protein of unknown function (DUF881) - - - - - - - - - - - - DUF881 k141_243_47 1151292.QEW_3193 1.09e-45 159.0 COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,25SZ2@186804|Peptostreptococcaceae 186801|Clostridia S Bacterial protein of unknown function (DUF881) - - - - - - - - - - - - DUF881 k141_243_48 1121324.CLIT_11c00530 1.04e-44 148.0 COG3856@1|root,COG3856@2|Bacteria,1VA6N@1239|Firmicutes,24N58@186801|Clostridia,25TFI@186804|Peptostreptococcaceae 186801|Clostridia S Protein of unknown function (DUF1290) sbp - - - - - - - - - - - DUF1290 k141_243_49 1121324.CLIT_11c00540 8.69e-173 492.0 COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,25QCR@186804|Peptostreptococcaceae 186801|Clostridia D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k141_243_50 1354300.AUQY01000002_gene909 1.42e-55 178.0 COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,22HHT@1570339|Peptoniphilaceae 186801|Clostridia K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k141_243_51 1511.CLOST_1888 5.01e-108 317.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,25QP7@186804|Peptostreptococcaceae 186801|Clostridia K response regulator phoP - - ko:K02483,ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_243_52 1121324.CLIT_11c00580 2.71e-141 416.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,25QXW@186804|Peptostreptococcaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein phoR2 - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like k141_243_53 1121930.AQXG01000003_gene2697 3.89e-21 92.8 COG1595@1|root,COG1595@2|Bacteria,4NQE0@976|Bacteroidetes 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k141_243_54 293826.Amet_3126 6.9e-10 68.9 COG1196@1|root,COG1196@2|Bacteria,1UIE6@1239|Firmicutes,25EJB@186801|Clostridia 186801|Clostridia D Domain of unknown function (DUF4349) - - - - - - - - - - - - DUF4349,zf-HC2 k141_243_56 1121324.CLIT_11c00670 0.0 1036.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,25QCY@186804|Peptostreptococcaceae 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k141_243_57 1110697.NCAST_26_01120 1.54e-19 93.2 COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4FUXF@85025|Nocardiaceae 201174|Actinobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE,GrpB k141_243_58 489825.LYNGBM3L_42030 1.83e-21 98.6 COG0457@1|root,COG0741@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,1G4F1@1117|Cyanobacteria,1H97X@1150|Oscillatoriales 1117|Cyanobacteria M Transglycosylase SLT domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,TPR_6 k141_243_59 994573.T472_0206885 2.29e-05 55.8 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,36WU1@31979|Clostridiaceae 186801|Clostridia E Extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k141_243_61 1122173.AXVL01000057_gene625 2.18e-34 130.0 COG0791@1|root,COG0791@2|Bacteria,37AR2@32066|Fusobacteria 32066|Fusobacteria M NlpC P60 family protein - - - - - - - - - - - - NLPC_P60 k141_243_63 1121324.CLIT_23c03240 7.23e-214 602.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,25QF7@186804|Peptostreptococcaceae 186801|Clostridia C Part of a membrane complex involved in electron transport rnfC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB k141_243_64 1121324.CLIT_23c03250 5.16e-169 478.0 COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k141_243_65 1121324.CLIT_23c03260 7.41e-63 199.0 COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03612 - - - - ko00000 - - - FMN_bind k141_243_66 1511.CLOST_1399 3.46e-101 298.0 COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,25QPE@186804|Peptostreptococcaceae 186801|Clostridia C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - iHN637.CLJU_RS05585 Rnf-Nqr k141_243_67 1286171.EAL2_c11460 2.85e-102 299.0 COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,25VXE@186806|Eubacteriaceae 186801|Clostridia C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k141_243_68 1121324.CLIT_23c03290 3.37e-142 409.0 COG1148@1|root,COG2878@1|root,COG1148@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,25QGD@186804|Peptostreptococcaceae 186801|Clostridia C Electron transport complex rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4,Fer4_13,Fer4_4,Fer4_9 k141_243_69 1183377.Py04_0372 1.61e-44 153.0 COG0424@1|root,arCOG05007@2157|Archaea,2XZIF@28890|Euryarchaeota,243F5@183968|Thermococci 183968|Thermococci D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k141_243_70 272563.CD630_11440 1.95e-85 260.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,25QVA@186804|Peptostreptococcaceae 186801|Clostridia E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k141_243_71 293826.Amet_2290 1.59e-177 504.0 COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae 186801|Clostridia D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k141_243_72 1511.CLOST_1394 3.05e-84 261.0 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,25R0B@186804|Peptostreptococcaceae 186801|Clostridia M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k141_243_74 1121324.CLIT_23c03350 0.0 965.0 COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,25QP8@186804|Peptostreptococcaceae 186801|Clostridia M Penicillin-binding protein, transpeptidase domain protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k141_243_75 1121324.CLIT_23c03360 3.6e-49 166.0 COG0850@1|root,COG0850@2|Bacteria,1VAPC@1239|Firmicutes,24MV1@186801|Clostridia,25TXB@186804|Peptostreptococcaceae 186801|Clostridia D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C k141_243_76 1121324.CLIT_23c03370 8.24e-139 398.0 COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia,25QSA@186804|Peptostreptococcaceae 186801|Clostridia D Cellulose biosynthesis protein BcsQ minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k141_243_77 1286171.EAL2_c11560 4.06e-33 117.0 COG0851@1|root,COG0851@2|Bacteria,1VFST@1239|Firmicutes,24QT6@186801|Clostridia,25WUI@186806|Eubacteriaceae 186801|Clostridia D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE k141_243_78 1286171.EAL2_c11570 1.92e-143 417.0 COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,25VRW@186806|Eubacteriaceae 186801|Clostridia D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k141_243_79 1408422.JHYF01000001_gene2921 5.39e-71 216.0 COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia,36IPD@31979|Clostridiaceae 186801|Clostridia G methylglyoxal synthase mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS k141_243_80 1304284.L21TH_2530 5.27e-200 568.0 COG2031@1|root,COG2031@2|Bacteria,1TPCQ@1239|Firmicutes,247SN@186801|Clostridia,36FA0@31979|Clostridiaceae 186801|Clostridia I Short chain fatty acid transporter - - - ko:K02106 ko02020,map02020 - - - ko00000,ko00001 2.A.73.1 - - SCFA_trans k141_243_82 1042156.CXIVA_06670 3.41e-74 223.0 COG1607@1|root,COG1607@2|Bacteria,1V3ZQ@1239|Firmicutes,24HF8@186801|Clostridia,36IT9@31979|Clostridiaceae 186801|Clostridia I Thioesterase superfamily kal - 4.3.1.14 ko:K18014 ko00310,map00310 - R03030 RC00833 ko00000,ko00001,ko01000 - - - 4HBT k141_75_3 857293.CAAU_1751 7.91e-68 213.0 COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,36JRA@31979|Clostridiaceae 186801|Clostridia E cyclohydrolase fchA - 4.3.1.4 ko:K01746 ko00670,ko01100,map00670,map01100 - R02302 RC00688 ko00000,ko00001,ko01000 - - - FTCD_C k141_75_4 1286171.EAL2_808p06020 3.63e-197 558.0 COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,25Y7G@186806|Eubacteriaceae 186801|Clostridia Q Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k141_75_5 1292035.H476_1936 5.8e-151 431.0 COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,25QZQ@186804|Peptostreptococcaceae 186801|Clostridia E Formiminotransferase domain, N-terminal subdomain ftcD - 2.1.2.5 ko:K00603 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R03189 RC00165,RC00221,RC00223,RC00870 ko00000,ko00001,ko01000 - - - FTCD,FTCD_N k141_75_6 1391646.AVSU01000086_gene545 0.0 1054.0 COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,25R5J@186804|Peptostreptococcaceae 186801|Clostridia E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k141_75_7 1286171.EAL2_c15140 1.99e-59 189.0 2CK8D@1|root,32SBU@2|Bacteria,1VAQG@1239|Firmicutes,24HSZ@186801|Clostridia 186801|Clostridia S Tryptophan transporter TrpP trpP - - - - - - - - - - iHN637.CLJU_RS14305 TrpP k141_75_8 572479.Hprae_0190 6e-49 199.0 COG4399@1|root,COG4399@2|Bacteria,1TQDH@1239|Firmicutes,24K94@186801|Clostridia,3WC4V@53433|Halanaerobiales 186801|Clostridia S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 k141_75_9 1121324.CLIT_10c03400 2.74e-96 293.0 COG1360@1|root,COG1360@2|Bacteria,1UYZY@1239|Firmicutes,25D7J@186801|Clostridia 186801|Clostridia N OmpA family - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k141_75_10 1304284.L21TH_0001 9.66e-68 222.0 COG0811@1|root,COG0811@2|Bacteria,1V2HH@1239|Firmicutes,24BCC@186801|Clostridia,36H09@31979|Clostridiaceae 186801|Clostridia U peptide transport - - - - - - - - - - - - MotA_ExbB k141_75_11 857293.CAAU_1822 2.71e-146 420.0 COG2066@1|root,COG2066@2|Bacteria,1TP64@1239|Firmicutes,2491K@186801|Clostridia,36EFX@31979|Clostridiaceae 186801|Clostridia E Belongs to the glutaminase family glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase k141_75_12 1408422.JHYF01000010_gene3356 3.95e-118 358.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36EYP@31979|Clostridiaceae 186801|Clostridia L helicase cshA2 - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k141_75_13 1111134.HMPREF1253_1088 1.26e-30 119.0 COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,22H8Y@1570339|Peptoniphilaceae 186801|Clostridia S Metallo-beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k141_75_14 1121324.CLIT_10c01090 4.68e-46 152.0 COG0642@1|root,COG2205@2|Bacteria,1VNVZ@1239|Firmicutes,24VI6@186801|Clostridia,25UAF@186804|Peptostreptococcaceae 186801|Clostridia T protein histidine kinase activity - - - - - - - - - - - - Usp k141_75_15 420246.GTNG_1153 1.67e-46 152.0 COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,4HIQV@91061|Bacilli,1WGP8@129337|Geobacillus 91061|Bacilli S Stage V sporulation protein S (SpoVS) spoVS - - ko:K06416 - - - - ko00000 - - - SpoVS k141_75_16 350688.Clos_1560 7.22e-117 342.0 COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,24AQJ@186801|Clostridia,36F2I@31979|Clostridiaceae 186801|Clostridia NT Methyltransferase cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k141_75_17 546269.HMPREF0389_01731 6.51e-104 317.0 COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,25R7T@186804|Peptostreptococcaceae 186801|Clostridia J Ribosomal protein S1-like RNA-binding domain ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k141_75_18 350688.Clos_1562 3.97e-89 273.0 COG0761@1|root,COG0761@2|Bacteria,1UHT7@1239|Firmicutes,25E67@186801|Clostridia,36UJG@31979|Clostridiaceae 186801|Clostridia IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB k141_75_19 1499689.CCNN01000007_gene1371 1.02e-71 224.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,36DDB@31979|Clostridiaceae 186801|Clostridia F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k141_75_20 1215915.BN193_05115 3.12e-11 68.2 COG0406@1|root,COG0406@2|Bacteria,1VDCB@1239|Firmicutes,4HM06@91061|Bacilli,1YBI2@1357|Lactococcus 91061|Bacilli G Phosphoglycerate mutase family gpmB - - - - - - - - - - - His_Phos_1 k141_75_21 1410661.JNKW01000012_gene1265 8.72e-137 402.0 COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia 186801|Clostridia L Belongs to the methyltransferase superfamily ypsC - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k141_75_22 903814.ELI_2050 2.77e-87 275.0 COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,25W7H@186806|Eubacteriaceae 186801|Clostridia S dinuclear metal center protein, YbgI - - - - - - - - - - - - NIF3 k141_75_23 1408823.AXUS01000004_gene136 5.19e-58 191.0 COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,25REY@186804|Peptostreptococcaceae 186801|Clostridia S tRNA (adenine(22)-N(1))-methyltransferase trmK - 2.1.1.217 ko:K06967 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_18,TrmK k141_75_24 1408823.AXUS01000004_gene137 2.35e-182 518.0 COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,25QZG@186804|Peptostreptococcaceae 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k141_75_25 1121324.CLIT_11c01730 8.22e-140 425.0 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,25QPP@186804|Peptostreptococcaceae 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k141_75_26 1408823.AXUS01000004_gene139 1.72e-120 350.0 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia 186801|Clostridia E PFAM DAHP synthetase I aroF - 2.5.1.54,5.4.99.5 ko:K01626,ko:K03856,ko:K13853 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k141_75_27 500633.CLOHIR_00228 1.99e-48 169.0 COG0801@1|root,COG2876@1|root,COG0801@2|Bacteria,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia 186801|Clostridia E PFAM DAHP synthetase I aroF - 2.5.1.54,5.4.99.5 ko:K01626,ko:K03856,ko:K13853 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k141_75_28 349161.Dred_0155 1.88e-34 122.0 COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia,262E7@186807|Peptococcaceae 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k141_75_29 315730.BcerKBAB4_0067 6.02e-89 272.0 COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,4H9SY@91061|Bacilli,1ZAPZ@1386|Bacillus 91061|Bacilli H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k141_75_30 1511.CLOST_1761 6.06e-107 311.0 COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,25RGH@186804|Peptostreptococcaceae 186801|Clostridia F GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k141_75_31 445973.CLOBAR_01939 1.16e-56 188.0 COG0115@1|root,COG0115@2|Bacteria,1V3JS@1239|Firmicutes,24JA5@186801|Clostridia,25SGJ@186804|Peptostreptococcaceae 186801|Clostridia EH Amino-transferase class IV pabC - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k141_75_32 926692.AZYG01000097_gene2334 5e-168 486.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WB6G@53433|Halanaerobiales 186801|Clostridia EH Anthranilate synthase component I, N terminal region pabB - 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Anth_synt_I_N,Chorismate_bind k141_75_33 1391646.AVSU01000053_gene945 6.01e-84 253.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,25QXV@186804|Peptostreptococcaceae 186801|Clostridia EH Peptidase C26 pabA - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17720 GATase k141_75_34 1121324.CLIT_11c01270 3.28e-36 125.0 COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia 186801|Clostridia S protein, YerC YecD - - - - - - - - - - - - Trp_repressor k141_75_36 1266845.Q783_08345 5.16e-41 140.0 COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,27GIE@186828|Carnobacteriaceae 91061|Bacilli F NDK ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k141_75_37 985762.SAGN_03255 1.63e-20 96.3 COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,4GX8W@90964|Staphylococcaceae 91061|Bacilli M Probably involved in cell-wall metabolism lytH GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,SH3_3 k141_75_39 908338.HMPREF9286_0625 2.78e-142 412.0 COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,24APU@186801|Clostridia,22G2G@1570339|Peptoniphilaceae 186801|Clostridia S UPF0365 protein - - - - - - - - - - - - YdfA_immunity k141_75_40 1286171.EAL2_c14340 1.11e-96 303.0 COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,247N5@186801|Clostridia 186801|Clostridia O Membrane-bound serine protease (ClpP class) yqeZ - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah k141_75_41 1035196.HMPREF9998_00498 2.38e-50 164.0 COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,25RGV@186804|Peptostreptococcaceae 186801|Clostridia S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY k141_75_42 1286171.EAL2_c14360 8.78e-23 88.6 COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia,25XHW@186806|Eubacteriaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k141_75_43 1230342.CTM_01275 1.02e-54 173.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,36JIP@31979|Clostridiaceae 186801|Clostridia FG Hit family hinT - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k141_75_44 1391646.AVSU01000026_gene2375 4.59e-172 497.0 COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,25QMB@186804|Peptostreptococcaceae 186801|Clostridia J tRNA methylthiotransferase yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k141_75_45 350688.Clos_1236 6.44e-66 212.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,36DGZ@31979|Clostridiaceae 186801|Clostridia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k141_75_46 1121324.CLIT_11c00890 9.15e-137 398.0 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,25R0W@186804|Peptostreptococcaceae 186801|Clostridia J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k141_75_47 1121324.CLIT_11c00880 2.6e-147 429.0 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,25QX8@186804|Peptostreptococcaceae 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k141_75_48 1511.CLOST_1793 0.0 894.0 COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,25QS1@186804|Peptostreptococcaceae 186801|Clostridia O MreB/Mbl protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k141_75_49 1121289.JHVL01000002_gene2356 3.07e-43 150.0 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,36IQB@31979|Clostridiaceae 186801|Clostridia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k141_75_50 1304284.L21TH_1370 7.76e-89 278.0 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,36DW8@31979|Clostridiaceae 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k141_75_51 1301100.HG529365_gene1420 3.32e-129 382.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,36DU5@31979|Clostridiaceae 186801|Clostridia H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM k141_75_52 642492.Clole_2008 2.72e-40 154.0 2AM2W@1|root,31BWX@2|Bacteria,1V84G@1239|Firmicutes,24DXG@186801|Clostridia 186801|Clostridia - - - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - Glucosaminidase k141_75_53 332101.JIBU02000027_gene2781 1.42e-116 344.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat XK27_00825 - - ko:K07090 - - - - ko00000 - - - TauE k141_18_1 649747.HMPREF0083_01234 7.55e-10 70.5 COG3209@1|root,COG3501@1|root,COG3209@2|Bacteria,COG3501@2|Bacteria,1TR8F@1239|Firmicutes,4IQ8Z@91061|Bacilli,2768X@186822|Paenibacillaceae 91061|Bacilli M RHS repeat-associated core domain - - - - - - - - - - - - - k141_18_5 439235.Dalk_1621 9.49e-88 297.0 COG0076@1|root,COG2939@1|root,COG0076@2|Bacteria,COG2939@2|Bacteria,1Q16U@1224|Proteobacteria,42YZ1@68525|delta/epsilon subdivisions,2WUCA@28221|Deltaproteobacteria,2MP6I@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Peptidase S10, serine carboxypeptidase - - - - - - - - - - - - - k141_18_6 446468.Ndas_1772 1.62e-138 407.0 COG0688@1|root,COG0688@2|Bacteria,2IBDY@201174|Actinobacteria 201174|Actinobacteria I Belongs to the phosphatidylserine decarboxylase family - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PSDC,PS_Dcarbxylase k141_18_8 573061.Clocel_1667 2.17e-99 296.0 COG2454@1|root,COG2454@2|Bacteria,1V42I@1239|Firmicutes,24BAF@186801|Clostridia,36FFD@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF434) - - - - - - - - - - - - DUF434 k141_18_9 717606.PaecuDRAFT_3460 1.71e-88 285.0 COG0464@1|root,COG0464@2|Bacteria,1UBVM@1239|Firmicutes,4ITDB@91061|Bacilli,277CY@186822|Paenibacillaceae 91061|Bacilli O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k141_18_11 1121447.JONL01000002_gene1797 4.23e-56 186.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,42MYK@68525|delta/epsilon subdivisions,2WN3P@28221|Deltaproteobacteria,2MBQ1@213115|Desulfovibrionales 28221|Deltaproteobacteria L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k141_18_12 1410653.JHVC01000034_gene3742 1.27e-20 105.0 COG1353@1|root,COG1353@2|Bacteria,1UZM3@1239|Firmicutes,24KWD@186801|Clostridia,36K3C@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_18_13 1410653.JHVC01000034_gene3743 4.96e-67 246.0 COG1337@1|root,COG1337@2|Bacteria,1VB9Y@1239|Firmicutes,24KU1@186801|Clostridia,36KKG@31979|Clostridiaceae 186801|Clostridia L RAMP superfamily - - - ko:K19134 - - - - ko00000,ko02048 - - - RAMPs k141_18_14 479436.Vpar_1814 1.43e-12 78.6 COG1337@1|root,COG1337@2|Bacteria,1V6T4@1239|Firmicutes,4H4BJ@909932|Negativicutes 909932|Negativicutes L CRISPR-associated RAMP protein - - - - - - - - - - - - RAMPs k141_18_16 1410653.JHVC01000034_gene3746 3.09e-98 328.0 COG1337@1|root,COG1337@2|Bacteria,1UZIC@1239|Firmicutes,24AP1@186801|Clostridia,36M4Q@31979|Clostridiaceae 186801|Clostridia L RAMP superfamily - - - - - - - - - - - - RAMPs k141_18_18 37659.JNLN01000001_gene1717 1.76e-53 208.0 COG1337@1|root,COG1337@2|Bacteria,1UZIC@1239|Firmicutes,24AP1@186801|Clostridia,36M4Q@31979|Clostridiaceae 186801|Clostridia L RAMP superfamily - - - - - - - - - - - - RAMPs k141_18_19 445335.CBN_0698 7.38e-46 189.0 2E8YT@1|root,3338E@2|Bacteria,1VFTE@1239|Firmicutes,24M7U@186801|Clostridia,36JWB@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_18_20 536232.CLM_0764 1.09e-135 440.0 COG1816@1|root,COG1816@2|Bacteria,1UHMY@1239|Firmicutes,24D5F@186801|Clostridia,36QBX@31979|Clostridiaceae 186801|Clostridia F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - - - - - - - - - - - A_deaminase k141_18_21 620914.JH621251_gene2376 2.46e-22 102.0 2ETUU@1|root,33MC2@2|Bacteria,4NZ8U@976|Bacteroidetes,1I9XH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k141_18_23 1230342.CTM_26103 2.61e-114 333.0 COG1515@1|root,COG1515@2|Bacteria,1V1CJ@1239|Firmicutes,24C24@186801|Clostridia,36HC9@31979|Clostridiaceae 186801|Clostridia L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k141_18_25 1391646.AVSU01000151_gene2689 2.27e-77 238.0 COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,25RMC@186804|Peptostreptococcaceae 186801|Clostridia K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k141_18_26 521460.Athe_1391 2.05e-08 55.5 COG1388@1|root,COG1388@2|Bacteria 2|Bacteria M LysM domain - - 3.5.1.28 ko:K01447,ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,Glyco_hydro_25,LysM k141_18_27 1121324.CLIT_11c02820 8.66e-292 816.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia 186801|Clostridia E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k141_18_29 1292035.H476_1062 1.46e-232 648.0 COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,25R6P@186804|Peptostreptococcaceae 186801|Clostridia P Aluminum resistance protein ynbB - - - - - - - - - - - Met_gamma_lyase k141_18_30 324831.LGAS_0884 4.4e-32 129.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,3F3V9@33958|Lactobacillaceae 91061|Bacilli D recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k141_18_31 1298920.KI911353_gene840 6.33e-64 207.0 COG3208@1|root,COG3208@2|Bacteria,1V5K3@1239|Firmicutes,24HA1@186801|Clostridia,222ZW@1506553|Lachnoclostridium 186801|Clostridia Q Thioesterase domain - - - - - - - - - - - - Nitroreductase,Thioesterase k141_18_32 588581.Cpap_1767 3.94e-202 610.0 COG1020@1|root,COG1020@2|Bacteria,1V004@1239|Firmicutes,24E28@186801|Clostridia,3WNET@541000|Ruminococcaceae 186801|Clostridia Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,PP-binding k141_18_34 588581.Cpap_1769 2.49e-125 371.0 COG4693@1|root,COG4693@2|Bacteria,1UY66@1239|Firmicutes,24ICV@186801|Clostridia,3WMUW@541000|Ruminococcaceae 186801|Clostridia Q Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,Methyltransf_12 k141_18_35 411469.EUBHAL_00448 3.4e-267 810.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,25W28@186806|Eubacteriaceae 186801|Clostridia Q Condensation domain - - - ko:K04784,ko:K12240 ko01053,map01053 - - - ko00000,ko00001,ko01004,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,NAD_binding_4,PP-binding,Thioesterase k141_18_36 588581.Cpap_1768 4.25e-90 290.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae 186801|Clostridia Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,NAD_binding_4,PP-binding,ketoacyl-synt k141_18_37 1123075.AUDP01000030_gene1832 3.37e-25 105.0 COG2091@1|root,COG2091@2|Bacteria,1VEYZ@1239|Firmicutes,24RQ3@186801|Clostridia,3WM4E@541000|Ruminococcaceae 186801|Clostridia H 4'-phosphopantetheinyl transferase superfamily sfp - - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k141_18_38 1487953.JMKF01000037_gene3244 2.34e-25 119.0 COG0236@1|root,COG0318@1|root,COG1960@1|root,COG0236@2|Bacteria,COG0318@2|Bacteria,COG1960@2|Bacteria,1G4XD@1117|Cyanobacteria 1117|Cyanobacteria IQ Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - AMP-binding,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,PP-binding k141_18_39 411902.CLOBOL_02199 0.0 1543.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,21Z42@1506553|Lachnoclostridium 186801|Clostridia Q Belongs to the ATP-dependent AMP-binding enzyme family - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding k141_18_40 1423806.JCM15457_674 2.01e-24 102.0 COG1309@1|root,COG1309@2|Bacteria,1UW9B@1239|Firmicutes,4I3WZ@91061|Bacilli,3F7T3@33958|Lactobacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k141_18_41 742741.HMPREF9475_02783 1.58e-188 549.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247VZ@186801|Clostridia,21Z8B@1506553|Lachnoclostridium 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k141_18_42 592026.GCWU0000282_001722 4.81e-169 499.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247PY@186801|Clostridia 186801|Clostridia V abc transporter atp-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k141_18_43 592026.GCWU0000282_002627 1.94e-69 217.0 2BY0N@1|root,2ZBND@2|Bacteria,1TS3Y@1239|Firmicutes,24EZ3@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K16926 - M00582 - - ko00000,ko00002,ko02000 3.A.1.31 - - Trep_Strep k141_18_44 910313.HMPREF9320_0333 2.26e-74 233.0 COG0619@1|root,COG0619@2|Bacteria,1TTA6@1239|Firmicutes,4IPJ5@91061|Bacilli 91061|Bacilli P Cobalt transport protein - - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ k141_193_80 398767.Glov_0393 4.21e-09 66.6 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WN7Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k141_193_82 1444310.JANV01000095_gene3186 1.49e-07 62.4 COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,1V6J2@1239|Firmicutes,4HJZH@91061|Bacilli,1ZBKG@1386|Bacillus 91061|Bacilli O ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - PG_binding_1,YkuD k141_193_83 1319815.HMPREF0202_00334 1.73e-73 228.0 COG0778@1|root,COG0778@2|Bacteria 2|Bacteria C coenzyme F420-1:gamma-L-glutamate ligase activity ydfN - - ko:K15976 - - - - ko00000,ko01000 - - - Nitroreductase k141_193_84 1121289.JHVL01000026_gene190 5.16e-115 331.0 COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,36EFS@31979|Clostridiaceae 186801|Clostridia C Rubrerythrin rbr3A - - - - - - - - - - - Rubrerythrin k141_73_35 1304284.L21TH_0421 8.21e-91 279.0 COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,36EYU@31979|Clostridiaceae 186801|Clostridia P Belongs to the bacterial solute-binding protein 9 family adcA - - ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - iHN637.CLJU_RS18655 ZnuA k141_73_36 1121324.CLIT_20c00450 1.04e-62 204.0 COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,248F1@186801|Clostridia 186801|Clostridia P Abc transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k141_73_37 572479.Hprae_0193 5.75e-95 287.0 COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,3WBG5@53433|Halanaerobiales 186801|Clostridia P PFAM ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k141_73_39 767817.Desgi_3117 3.16e-09 67.4 COG0457@1|root,COG0457@2|Bacteria,1V54K@1239|Firmicutes,24JYK@186801|Clostridia 186801|Clostridia S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8,VCBS k141_73_40 272563.CD630_17820 4.23e-83 254.0 COG0745@1|root,COG0745@2|Bacteria,1TPN8@1239|Firmicutes,248UA@186801|Clostridia,25QNR@186804|Peptostreptococcaceae 186801|Clostridia KT Response regulator receiver domain protein - - - - - - - - - - - - Response_reg,Trans_reg_C k141_73_41 411465.PEPMIC_01545 9.35e-51 187.0 COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,22GWE@1570339|Peptoniphilaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein phoR2 - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_73_43 869213.JCM21142_42031 4.32e-38 129.0 COG2158@1|root,COG2158@2|Bacteria 2|Bacteria S Cysteine-rich small domain cbiA - - ko:K07162 - - - - ko00000 - - - zf-like k141_73_44 1476973.JMMB01000007_gene195 1.95e-176 515.0 COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,25QF4@186804|Peptostreptococcaceae 186801|Clostridia H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k141_73_45 457396.CSBG_03380 1.3e-36 127.0 COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,36JG6@31979|Clostridiaceae 186801|Clostridia S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k141_73_46 500633.CLOHIR_02068 3.71e-112 325.0 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,25QKA@186804|Peptostreptococcaceae 186801|Clostridia L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k141_73_49 536227.CcarbDRAFT_2794 3.3e-73 250.0 COG0840@1|root,COG0840@2|Bacteria,1TPI1@1239|Firmicutes,248XZ@186801|Clostridia,36FK2@31979|Clostridiaceae 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 k141_73_51 272563.CD630_00190 3.03e-139 409.0 COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,25QU0@186804|Peptostreptococcaceae 186801|Clostridia M Monogalactosyldiacylglycerol synthase ugtP - 2.4.1.315 ko:K03429 ko00561,ko01100,map00561,map01100 - R02689,R04377 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT28 - Glyco_tran_28_C,Glycos_transf_1,MGDG_synth k141_73_52 1443125.Z962_02790 7.54e-108 327.0 COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EE4@31979|Clostridiaceae 186801|Clostridia S hmm pf01594 - - - - - - - - - - - - AI-2E_transport k141_73_53 1286171.EAL2_c00450 1.82e-29 106.0 COG0695@1|root,COG0695@2|Bacteria,1UF2R@1239|Firmicutes,25NBW@186801|Clostridia,25Z45@186806|Eubacteriaceae 186801|Clostridia O Glutaredoxin - - - - - - - - - - - - Glutaredoxin k141_73_55 1121324.CLIT_16c00290 7.3e-103 304.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia 186801|Clostridia S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k141_73_56 1301100.HG529292_gene5164 1.81e-224 632.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae 186801|Clostridia C Na H antiporter - - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k141_73_57 1211817.CCAT010000012_gene2760 1.88e-285 801.0 COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,36DJY@31979|Clostridiaceae 186801|Clostridia C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k141_74_3 1379698.RBG1_1C00001G0745 1.32e-60 217.0 COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k141_74_4 515635.Dtur_0535 5.48e-36 136.0 COG1237@1|root,COG1237@2|Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k141_138_1 1121324.CLIT_24c00030 1.56e-201 579.0 COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,25QTE@186804|Peptostreptococcaceae 186801|Clostridia S Stage V sporulation protein B spoVB - - ko:K06409 - - - - ko00000,ko02000 2.A.66.2.14 - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k141_138_2 667014.Thein_1029 5.16e-25 110.0 COG0760@1|root,COG0760@2|Bacteria,2GHMC@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 k141_138_3 1151292.QEW_4128 0.0 1221.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,25QCA@186804|Peptostreptococcaceae 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k141_138_4 720554.Clocl_0324 1e-79 243.0 COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae 186801|Clostridia J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k141_138_5 1121324.CLIT_24c00070 3.7e-174 491.0 COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,25QGP@186804|Peptostreptococcaceae 186801|Clostridia F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k141_138_6 1408823.AXUS01000010_gene1824 9.26e-177 509.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,25QZH@186804|Peptostreptococcaceae 186801|Clostridia M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k141_138_7 1123009.AUID01000005_gene1607 1.37e-40 136.0 COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,269C7@186813|unclassified Clostridiales 186801|Clostridia M Could be involved in septation spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG k141_138_8 596329.HMPREF0631_1506 6.99e-128 371.0 COG0503@1|root,COG0503@2|Bacteria,1TPN9@1239|Firmicutes,25CKT@186801|Clostridia,25QE2@186804|Peptostreptococcaceae 186801|Clostridia F operon repressor purR - - ko:K09685 - - - - ko00000,ko03000 - - - Pribosyltran,PuR_N k141_138_9 1408823.AXUS01000010_gene1821 1.22e-155 455.0 COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,25R68@186804|Peptostreptococcaceae 186801|Clostridia M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k141_138_10 309798.COPRO5265_1261 4.3e-08 55.5 2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,42GYR@68295|Thermoanaerobacterales 186801|Clostridia S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD k141_138_11 445973.CLOBAR_02512 1.62e-106 320.0 COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,25SS5@186804|Peptostreptococcaceae 186801|Clostridia P Dimerisation domain of Zinc Transporter fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k141_138_13 1301100.HG529431_gene1834 4.41e-178 506.0 COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae 186801|Clostridia E Cleaves the N-terminal amino acid of tripeptides - - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k141_138_14 1286171.EAL2_c02070 1.07e-122 359.0 COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,25V9W@186806|Eubacteriaceae 186801|Clostridia J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k141_138_15 596315.HMPREF0634_0175 1.84e-72 223.0 COG1658@1|root,COG1658@2|Bacteria,1V3K3@1239|Firmicutes,24I8W@186801|Clostridia,25QDT@186804|Peptostreptococcaceae 186801|Clostridia J Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step rnmV - 3.1.26.8 ko:K05985 - - - - ko00000,ko01000 - - - DUF4093,Toprim,Toprim_4 k141_138_16 1123009.AUID01000007_gene638 1.25e-52 181.0 COG0697@1|root,COG0697@2|Bacteria,1V3QH@1239|Firmicutes,24I9P@186801|Clostridia 186801|Clostridia EG Permeases of the drug metabolite transporter (DMT) - - - - - - - - - - - - EamA k141_138_18 1226325.HMPREF1548_03725 5.83e-50 186.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DKF@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_138_19 926561.KB900617_gene1377 3.73e-54 180.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k141_138_20 457415.HMPREF1006_01205 1.37e-29 105.0 COG1773@1|root,COG1773@2|Bacteria,3TBI8@508458|Synergistetes 508458|Synergistetes C PFAM Rubredoxin-type Fe(Cys)4 protein - - - - - - - - - - - - Rubredoxin k141_138_21 293826.Amet_0136 2.18e-53 186.0 COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,36DTZ@31979|Clostridiaceae 186801|Clostridia S G5 domain protein yabE - - - - - - - - - - - 3D,DUF348,G5 k141_138_22 1121324.CLIT_24c00160 1.01e-44 151.0 2C0BT@1|root,345WP@2|Bacteria,1VYGN@1239|Firmicutes,2536W@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_138_23 596323.HMPREF0554_0343 3.22e-104 316.0 COG1840@1|root,COG1840@2|Bacteria,3797Q@32066|Fusobacteria 32066|Fusobacteria P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k141_138_24 536232.CLM_1231 9.66e-191 544.0 COG2271@1|root,COG2271@2|Bacteria,1TS33@1239|Firmicutes,248WJ@186801|Clostridia,36FWX@31979|Clostridiaceae 186801|Clostridia G transporter glpT - - ko:K02445,ko:K07783 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.1.4.3,2.A.1.4.4,2.A.1.4.6 - - MFS_1 k141_138_25 358681.BBR47_02840 6.05e-171 487.0 COG0584@1|root,COG0584@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli 91061|Bacilli C glycerophosphoryl diester phosphodiesterase glpQ - 3.1.3.1,3.1.4.46 ko:K01113,ko:K01126 ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020 M00126 R01030,R01470,R04620 RC00017,RC00425 ko00000,ko00001,ko00002,ko01000 - - - GDPD k141_138_26 985665.HPL003_16595 3.61e-67 228.0 COG3037@1|root,COG3037@2|Bacteria,1TQK5@1239|Firmicutes,4HBAD@91061|Bacilli,26SPU@186822|Paenibacillaceae 91061|Bacilli S PTS system sugar-specific permease component ulaA - - ko:K03475 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.7.1 - - EIIC-GAT k141_138_28 272558.10172832 2.95e-73 258.0 COG1762@1|root,COG3711@1|root,COG1762@2|Bacteria,COG3711@2|Bacteria,1TQT1@1239|Firmicutes,4H9N4@91061|Bacilli,1ZBCM@1386|Bacillus 91061|Bacilli GKT COG3711 Transcriptional antiterminator - - 2.7.1.194 ko:K02821,ko:K03483 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000,ko03000 4.A.7.1 - - HTH_11,Mga,PRD,PTS_EIIA_2,PTS_IIB k141_138_29 1391646.AVSU01000045_gene1480 2.88e-125 363.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,25QD1@186804|Peptostreptococcaceae 186801|Clostridia L TatD related DNase tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k141_138_31 985665.HPL003_27395 3.71e-17 84.3 COG1357@1|root,COG1357@2|Bacteria,1VNCI@1239|Firmicutes,4I7UV@91061|Bacilli,26XPD@186822|Paenibacillaceae 91061|Bacilli S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - - k141_138_33 398512.JQKC01000008_gene813 1.17e-34 123.0 2EE7B@1|root,3381W@2|Bacteria,1VAIC@1239|Firmicutes 1239|Firmicutes S Domain of unknown function (DUF4280) - - - - - - - - - - - - DUF4280 k141_138_35 1163671.JAGI01000002_gene3502 9.1e-27 114.0 COG3501@1|root,COG3501@2|Bacteria,1TSS0@1239|Firmicutes,25BBM@186801|Clostridia,36WKM@31979|Clostridiaceae 186801|Clostridia S Rhs element vgr protein - - - - - - - - - - - - Phage_GPD k141_119_1 1286171.EAL2_c13040 1.18e-46 154.0 2EB46@1|root,3354W@2|Bacteria,1VGP3@1239|Firmicutes,24J4K@186801|Clostridia 186801|Clostridia S Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k141_119_2 293826.Amet_2618 2.77e-203 572.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DT7@31979|Clostridiaceae 186801|Clostridia E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS10450 Aminotran_1_2 k141_119_3 1286171.EAL2_c13070 4.62e-105 312.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,25VRX@186806|Eubacteriaceae 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k141_119_4 272563.CD630_11740 2.65e-125 376.0 COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,25QMM@186804|Peptostreptococcaceae 186801|Clostridia S Belongs to the UPF0348 family - - - - - - - - - - - - HIGH_NTase1 k141_119_5 273068.TTE1485 1.15e-11 66.2 COG1193@1|root,COG1193@2|Bacteria,1UHZ5@1239|Firmicutes,25E7T@186801|Clostridia,42GTB@68295|Thermoanaerobacterales 186801|Clostridia L negative regulation of DNA recombination - - - - - - - - - - - - - k141_119_6 755731.Clo1100_2221 9.09e-61 192.0 COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,36IRH@31979|Clostridiaceae 186801|Clostridia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k141_119_7 1391646.AVSU01000054_gene1179 3.38e-62 197.0 COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,25RB7@186804|Peptostreptococcaceae 186801|Clostridia L RNA methyltransferase, RsmD family rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k141_119_8 500633.CLOHIR_01123 5.29e-243 696.0 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,25QY1@186804|Peptostreptococcaceae 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k141_119_9 1410653.JHVC01000005_gene2503 1.52e-72 267.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia,36DWM@31979|Clostridiaceae 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12,Trans_reg_C k141_119_12 891968.Anamo_0332 7.59e-14 68.2 arCOG03655@1|root,32S08@2|Bacteria,3TBHS@508458|Synergistetes 508458|Synergistetes - - - - - - - - - - - - - - - k141_119_13 1121289.JHVL01000041_gene3068 2.71e-109 327.0 COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,36FM0@31979|Clostridiaceae 186801|Clostridia D Arsenite-activated ATPase ArsA - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k141_119_14 1408422.JHYF01000017_gene1894 9.42e-112 328.0 COG0171@1|root,COG0171@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k141_119_16 1280671.AUJH01000003_gene1396 4.48e-05 46.6 2DQHF@1|root,336V9@2|Bacteria,1VIX0@1239|Firmicutes,24T9J@186801|Clostridia,4BZ4U@830|Butyrivibrio 186801|Clostridia - - - - - - - - - - - - - - - k141_119_17 1391646.AVSU01000009_gene39 4.14e-227 638.0 COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,25QU6@186804|Peptostreptococcaceae 186801|Clostridia E M18 family aminopeptidase apeA - - - - - - - - - - - Peptidase_M18 k141_119_18 293826.Amet_4648 1.06e-244 698.0 COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,36UJ4@31979|Clostridiaceae 186801|Clostridia G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k141_119_19 941824.TCEL_02082 6.83e-159 459.0 COG0025@1|root,COG0025@2|Bacteria,1UHUI@1239|Firmicutes,25E2Y@186801|Clostridia,36UH5@31979|Clostridiaceae 186801|Clostridia P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k141_119_20 1286171.EAL2_c21040 0.0 1229.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,25VEG@186806|Eubacteriaceae 186801|Clostridia G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k141_119_21 1121324.CLIT_11c01220 3.18e-134 387.0 COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,249ID@186801|Clostridia 186801|Clostridia S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation yqfL - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k141_119_22 1121324.CLIT_11c01210 4.27e-94 280.0 COG0517@1|root,COG0517@2|Bacteria,1TRZD@1239|Firmicutes,24851@186801|Clostridia,25UNT@186804|Peptostreptococcaceae 186801|Clostridia K Domain in cystathionine beta-synthase and other proteins. ccpN - - - - - - - - - - - CBS,HTH_11 k141_119_23 1151292.QEW_2986 1.81e-291 819.0 COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,25R5C@186804|Peptostreptococcaceae 186801|Clostridia J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k141_208_27 398512.JQKC01000018_gene2944 3.51e-69 242.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,3WN4Q@541000|Ruminococcaceae 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1,sCache_2 k141_208_28 610130.Closa_3879 1.12e-43 174.0 COG0840@1|root,COG3437@1|root,COG0840@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,223RM@1506553|Lachnoclostridium 186801|Clostridia T Diguanylate cyclase and metal dependent phosphohydrolase - - - - - - - - - - - - GGDEF,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9 k141_208_29 1292035.H476_0175 2.75e-23 95.5 2C8AN@1|root,32S6B@2|Bacteria,1VCS0@1239|Firmicutes,24JFN@186801|Clostridia,25RPP@186804|Peptostreptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_208_30 1121324.CLIT_17c00070 2.12e-122 367.0 28IKA@1|root,2Z8M2@2|Bacteria,1TTAG@1239|Firmicutes,24CCS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_208_31 1121324.CLIT_17c00060 2.86e-185 526.0 COG0297@1|root,COG0297@2|Bacteria,1UHWI@1239|Firmicutes,25E5D@186801|Clostridia 186801|Clostridia G Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k141_208_32 1286171.EAL2_c01060 2.56e-271 760.0 COG0664@1|root,COG1216@1|root,COG0664@2|Bacteria,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - ko:K15762 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002 - - - GlcNAc,Glyco_tranf_2_3,Glycos_transf_2,cNMP_binding k141_208_33 1121324.CLIT_17c00040 7.29e-176 511.0 COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,248KF@186801|Clostridia,25S2U@186804|Peptostreptococcaceae 186801|Clostridia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k141_208_34 1286171.EAL2_c02710 1.27e-63 215.0 COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia 186801|Clostridia T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD,HD_5 k141_208_35 445973.CLOBAR_02493 5.23e-114 353.0 COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,25QV5@186804|Peptostreptococcaceae 186801|Clostridia E Orn Lys Arg decarboxylase, major domain protein - - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C k141_208_36 1121324.CLIT_13c00040 5.09e-176 510.0 COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,25R1D@186804|Peptostreptococcaceae 186801|Clostridia S Tetrapyrrole methylase mazG - 3.6.1.66 ko:K02428,ko:K02499 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG,TP_methylase k141_208_38 596329.HMPREF0631_0292 5.81e-25 95.5 COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia,25RR5@186804|Peptostreptococcaceae 186801|Clostridia J S4 domain protein hslR - - - - - - - - - - - S4 k141_208_39 273068.TTE2445 1.18e-05 50.4 COG2919@1|root,COG2919@2|Bacteria,1VIN8@1239|Firmicutes,24U23@186801|Clostridia,42HDA@68295|Thermoanaerobacterales 186801|Clostridia D PFAM Septum formation initiator - - - - - - - - - - - - DivIC k141_208_40 1121324.CLIT_13c00080 4.02e-109 326.0 COG0248@1|root,COG0248@2|Bacteria,1V978@1239|Firmicutes,25CYW@186801|Clostridia,25UN4@186804|Peptostreptococcaceae 186801|Clostridia FP Ppx/GppA phosphatase family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k141_70_3 293826.Amet_4795 4.63e-89 270.0 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,36EMZ@31979|Clostridiaceae 186801|Clostridia J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k141_70_4 1511.CLOST_2581 1.5e-305 850.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,25QGE@186804|Peptostreptococcaceae 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k141_70_5 272563.CD630_36760 1.46e-198 565.0 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,25QGZ@186804|Peptostreptococcaceae 186801|Clostridia J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k141_70_6 1216932.CM240_2691 5.31e-58 188.0 COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,36F11@31979|Clostridiaceae 186801|Clostridia S R3H domain protein jag - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k141_70_7 1286171.EAL2_c22250 5.43e-79 243.0 COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,25VNJ@186806|Eubacteriaceae 186801|Clostridia U Membrane protein insertase, YidC Oxa1 family oxaA - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP k141_70_8 1035196.HMPREF9998_00137 2.33e-31 111.0 COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia 186801|Clostridia S Could be involved in insertion of integral membrane proteins into the membrane yidD - - ko:K08998 - - - - ko00000 - - - Haemolytic k141_70_9 1280698.AUJS01000048_gene424 2.98e-32 116.0 COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,27VP3@189330|Dorea 186801|Clostridia J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k141_70_11 1286171.EAL2_c00010 1.01e-212 600.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,25UYE@186806|Eubacteriaceae 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k141_70_12 1121324.CLIT_4c02210 3.93e-162 465.0 COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,25QH8@186804|Peptostreptococcaceae 186801|Clostridia L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k141_70_13 1226322.HMPREF1545_04108 2.48e-15 70.5 COG2501@1|root,COG2501@2|Bacteria,1TU9W@1239|Firmicutes,25NDU@186801|Clostridia,2N7QR@216572|Oscillospiraceae 186801|Clostridia S S4 domain - - - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 k141_70_14 1391646.AVSU01000021_gene3244 6.56e-139 407.0 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,25R56@186804|Peptostreptococcaceae 186801|Clostridia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k141_70_16 1286171.EAL2_c00060 0.0 960.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,25VFV@186806|Eubacteriaceae 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k141_70_17 1121324.CLIT_4c02260 0.0 1036.0 COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,25R3D@186804|Peptostreptococcaceae 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k141_70_20 1511.CLOST_0010 2.86e-32 115.0 COG1366@1|root,COG1366@2|Bacteria,1VER8@1239|Firmicutes,24QWE@186801|Clostridia,25RX7@186804|Peptostreptococcaceae 186801|Clostridia T Belongs to the anti-sigma-factor antagonist family rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS k141_70_21 1286171.EAL2_c00110 2.92e-52 170.0 COG2172@1|root,COG2172@2|Bacteria,1V1IA@1239|Firmicutes,24Q6W@186801|Clostridia,25ZQC@186806|Eubacteriaceae 186801|Clostridia T Histidine kinase-like ATPase domain rsbW - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 k141_70_22 1121324.CLIT_4c02310 3.47e-137 395.0 COG1191@1|root,COG1191@2|Bacteria,1TP3Q@1239|Firmicutes,2487Z@186801|Clostridia,25QQQ@186804|Peptostreptococcaceae 186801|Clostridia K Sigma-70 region 3 sigB - - ko:K03090,ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k141_144_1 1286171.EAL2_c21850 7.82e-217 609.0 COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,25URW@186806|Eubacteriaceae 186801|Clostridia M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k141_144_2 1219626.HMPREF1639_09010 1.61e-98 296.0 COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia,25QID@186804|Peptostreptococcaceae 186801|Clostridia S Metallo-beta-lactamase domain protein yycJ - - - - - - - - - - - Lactamase_B,Lactamase_B_2 k141_144_3 386415.NT01CX_0672 9.94e-81 249.0 COG2013@1|root,COG2013@2|Bacteria,1TSVH@1239|Firmicutes,24DQR@186801|Clostridia,36R6E@31979|Clostridiaceae 186801|Clostridia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k141_144_4 929506.CbC4_2400 5.75e-73 228.0 COG2310@1|root,COG2310@2|Bacteria,1TNZQ@1239|Firmicutes,24A3Y@186801|Clostridia,36GMM@31979|Clostridiaceae 186801|Clostridia T resistance protein terD_2 - - ko:K05795 - - - - ko00000 - - - TerD k141_144_6 929506.CbC4_0126 2.94e-198 572.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36DXA@31979|Clostridiaceae 186801|Clostridia L Belongs to the DEAD box helicase family cshA - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k141_144_8 1121447.JONL01000001_gene319 5.53e-07 53.1 COG2703@1|root,COG2703@2|Bacteria,1PG7G@1224|Proteobacteria,4360D@68525|delta/epsilon subdivisions,2X0HW@28221|Deltaproteobacteria,2MCDB@213115|Desulfovibrionales 28221|Deltaproteobacteria P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k141_144_10 1423815.BACR01000038_gene1913 4.09e-06 53.5 COG0789@1|root,COG0789@2|Bacteria,1V6C0@1239|Firmicutes,4HI5N@91061|Bacilli,3F6NG@33958|Lactobacillaceae 91061|Bacilli K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k141_144_12 622312.ROSEINA2194_04451 9.75e-07 51.2 COG1595@1|root,COG1595@2|Bacteria,1VCZT@1239|Firmicutes,25BT1@186801|Clostridia 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k141_144_16 1410653.JHVC01000007_gene617 8e-51 166.0 2CFUA@1|root,32S2G@2|Bacteria,1V63K@1239|Firmicutes,24N34@186801|Clostridia,36K8A@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_113_2 573061.Clocel_1186 1.81e-67 207.0 COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,24J8G@186801|Clostridia,36IYZ@31979|Clostridiaceae 186801|Clostridia S Secondary thiamine-phosphate synthase enzyme - - - - - - - - - - - - UPF0047 k141_113_3 1511.CLOST_1046 0.0 1108.0 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia,25SIU@186804|Peptostreptococcaceae 186801|Clostridia KL Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3427,Helicase_C,PLDc_2,ResIII k141_113_4 140626.JHWB01000022_gene2132 1.09e-48 170.0 COG2816@1|root,COG2816@2|Bacteria,1TRMF@1239|Firmicutes,24AXA@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k141_113_9 1121324.CLIT_2c01540 2.53e-80 244.0 COG1878@1|root,COG1878@2|Bacteria,1V2DJ@1239|Firmicutes,24HUC@186801|Clostridia 186801|Clostridia S cyclase family - - - - - - - - - - - - Cyclase k141_113_10 1408439.JHXW01000010_gene115 8.99e-49 160.0 COG1846@1|root,COG1846@2|Bacteria,37BAW@32066|Fusobacteria 32066|Fusobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k141_113_13 1211817.CCAT010000083_gene1573 9.18e-33 120.0 COG4939@1|root,COG4939@2|Bacteria,1VJ2S@1239|Firmicutes,24M0K@186801|Clostridia,36MA1@31979|Clostridiaceae 186801|Clostridia S FMN_bind - - - - - - - - - - - - FMN_bind k141_113_14 1008453.HMPREF9957_1031 8.03e-20 98.6 COG0477@1|root,COG2814@2|Bacteria,1VRUU@1239|Firmicutes,4HU3E@91061|Bacilli 91061|Bacilli EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k141_113_16 580331.Thit_2151 1.79e-17 79.7 COG5341@1|root,COG5341@2|Bacteria,1VEPD@1239|Firmicutes,24QPH@186801|Clostridia,42GIW@68295|Thermoanaerobacterales 186801|Clostridia S NusG domain II - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - NusG_II k141_113_17 1280688.AUJB01000008_gene645 8.88e-32 119.0 COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia,3NHBS@46205|Pseudobutyrivibrio 186801|Clostridia S Heptaprenyl diphosphate synthase component I - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - Hpre_diP_synt_I k141_113_18 1487921.DP68_12030 6.14e-105 318.0 COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,36DZZ@31979|Clostridiaceae 186801|Clostridia H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k141_113_19 358681.BBR47_16050 1.41e-112 361.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_113_20 1033737.CAEV01000098_gene1736 2.25e-241 692.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k141_113_21 293826.Amet_0592 8.76e-153 438.0 COG2515@1|root,COG2515@2|Bacteria,1UDCW@1239|Firmicutes,24BXZ@186801|Clostridia,36GV4@31979|Clostridiaceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k141_113_22 1304866.K413DRAFT_3281 4.11e-214 599.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,36DKQ@31979|Clostridiaceae 186801|Clostridia E PFAM Aminotransferase class I and II patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k141_113_23 457421.CBFG_03027 2.43e-225 629.0 COG1301@1|root,COG1301@2|Bacteria,1TQ3F@1239|Firmicutes,25CGZ@186801|Clostridia,26AP7@186813|unclassified Clostridiales 186801|Clostridia U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF k141_234_6 1121324.CLIT_23c01230 0.0 1316.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25QNK@186804|Peptostreptococcaceae 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k141_234_7 1345023.M467_11980 0.000189 50.8 COG0454@1|root,COG0454@2|Bacteria,COG0456@2|Bacteria,1VCMV@1239|Firmicutes,4HN6T@91061|Bacilli 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k141_234_8 1304284.L21TH_1191 9.9e-187 535.0 COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,36FI9@31979|Clostridiaceae 186801|Clostridia E HMGL-like - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450 - - - - - - - - - iHN637.CLJU_RS03250 HMGL-like k141_234_9 1304284.L21TH_1190 4.54e-273 769.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,36FJS@31979|Clostridiaceae 186801|Clostridia C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k141_234_10 536232.CLM_0498 2.49e-129 379.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate icd - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k141_234_11 1121289.JHVL01000009_gene1417 6.94e-67 237.0 COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1UMAC@1239|Firmicutes,25GDF@186801|Clostridia 186801|Clostridia T ABC transporter substrate binding protein - - - - - - - - - - - - - k141_234_12 1122947.FR7_2357 7.02e-40 148.0 COG3437@1|root,COG3437@2|Bacteria,1UYCB@1239|Firmicutes,4H2H0@909932|Negativicutes 909932|Negativicutes T SMART metal-dependent phosphohydrolase, HD region - - - - - - - - - - - - DUF3369,HD,Response_reg k141_234_13 1304284.L21TH_2667 2.17e-240 670.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae 186801|Clostridia E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k141_234_14 1286171.EAL2_c16060 1.67e-74 231.0 COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,25WEB@186806|Eubacteriaceae 186801|Clostridia P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k141_234_15 35841.BT1A1_1115 7.36e-131 377.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4HAB1@91061|Bacilli,1ZBQ5@1386|Bacillus 91061|Bacilli P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k141_234_16 350688.Clos_0268 1.28e-106 317.0 COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,36DCX@31979|Clostridiaceae 186801|Clostridia P Phosphate transport system permease protein PstA pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k141_234_17 1121289.JHVL01000030_gene391 8.37e-125 366.0 COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,36DTN@31979|Clostridiaceae 186801|Clostridia P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k141_234_18 1121289.JHVL01000030_gene390 1.02e-110 329.0 COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,36F61@31979|Clostridiaceae 186801|Clostridia P TIGRFAM phosphate binding protein pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k141_234_19 536233.CLO_2217 7.08e-39 149.0 COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,36FJB@31979|Clostridiaceae 186801|Clostridia T SMART Metal-dependent phosphohydrolase, HD region - - - - - - - - - - - - HD,HD_5 k141_234_20 1391646.AVSU01000057_gene1251 3.19e-74 235.0 COG1307@1|root,COG1307@2|Bacteria,1TSKD@1239|Firmicutes 1239|Firmicutes S EDD domain protein, DegV family yitS - - - - - - - - - - - DegV k141_234_21 203119.Cthe_0805 1.21e-55 177.0 COG0745@1|root,COG0745@2|Bacteria,1V774@1239|Firmicutes,24JS3@186801|Clostridia,3WJRP@541000|Ruminococcaceae 186801|Clostridia T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k141_234_22 332101.JIBU02000004_gene164 1.56e-80 283.0 COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36EKZ@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg,sCache_3_3 k141_234_23 646529.Desaci_0840 6.76e-106 321.0 COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,249FD@186801|Clostridia,26159@186807|Peptococcaceae 186801|Clostridia NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k141_234_24 720554.Clocl_1549 4.14e-55 206.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,3WHE0@541000|Ruminococcaceae 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k141_234_25 203119.Cthe_3029 5.01e-36 130.0 COG0835@1|root,COG0835@2|Bacteria,1V431@1239|Firmicutes,24HHD@186801|Clostridia,3WP6Y@541000|Ruminococcaceae 186801|Clostridia NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k141_234_26 509191.AEDB02000109_gene5081 2.3e-228 659.0 COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WH05@541000|Ruminococcaceae 186801|Clostridia NT Signal transducing histidine kinase homodimeric cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k141_234_28 1286171.EAL2_c16130 3.33e-38 134.0 COG0589@1|root,COG0589@2|Bacteria,1VZCK@1239|Firmicutes,253YG@186801|Clostridia,25Z3J@186806|Eubacteriaceae 2|Bacteria T Universal stress protein family - - - - - - - - - - - - Usp k141_234_29 1151292.QEW_3934 5.91e-227 636.0 COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,25QK4@186804|Peptostreptococcaceae 186801|Clostridia G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k141_234_30 7425.NV16146-PA 8.26e-79 247.0 COG0388@1|root,KOG0806@2759|Eukaryota,38TQE@33154|Opisthokonta,3B9AV@33208|Metazoa,3CSJF@33213|Bilateria,41TCG@6656|Arthropoda,3SFRS@50557|Insecta,46HRD@7399|Hymenoptera 33208|Metazoa E Carbon-nitrogen hydrolase NIT2 GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006082,GO:0006107,GO:0006520,GO:0006528,GO:0006541,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0009064,GO:0009066,GO:0009987,GO:0012505,GO:0015630,GO:0016192,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032787,GO:0032940,GO:0034641,GO:0034774,GO:0035580,GO:0036230,GO:0042119,GO:0042581,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044430,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046903,GO:0050152,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0070820,GO:0071704,GO:0097708,GO:0099503,GO:1901564,GO:1901605,GO:1904724 3.5.1.3 ko:K13101,ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000,ko03041 - - - CN_hydrolase k141_234_31 1487921.DP68_10000 1.23e-195 559.0 COG3104@1|root,COG3104@2|Bacteria,1TP81@1239|Firmicutes,24BI4@186801|Clostridia,36FG1@31979|Clostridiaceae 186801|Clostridia P amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k141_234_32 1121324.CLIT_23c01120 1.06e-245 691.0 COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,25QKI@186804|Peptostreptococcaceae 186801|Clostridia P Na Pi-cotransporter II-like protein - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k141_234_33 1301100.HG529382_gene4017 1.01e-211 604.0 COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,36DE1@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase - - - ko:K07137 - - - - ko00000 - - - HI0933_like,NAD_binding_8,Pyr_redox_2 k141_234_35 1286171.EAL2_c16190 3.21e-52 175.0 COG3879@1|root,COG3879@2|Bacteria,1VDG3@1239|Firmicutes,24PW0@186801|Clostridia 186801|Clostridia S Bacterial protein of unknown function (DUF881) - - - - - - - - - - - - DUF881 k141_234_37 1476973.JMMB01000007_gene3145 1.5e-101 298.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,25QD6@186804|Peptostreptococcaceae 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k141_234_38 1286171.EAL2_c16240 0.0 1000.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,25VQG@186806|Eubacteriaceae 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k141_234_39 1151292.QEW_3952 6.63e-47 157.0 COG2059@1|root,COG2059@2|Bacteria,1V43H@1239|Firmicutes,24JTX@186801|Clostridia,25TCU@186804|Peptostreptococcaceae 186801|Clostridia P Chromate transporter chrA - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k141_234_40 994573.T472_0215605 1.33e-39 139.0 COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,36ICK@31979|Clostridiaceae 186801|Clostridia P Chromate - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k141_234_41 1121324.CLIT_23c01000 1.03e-241 672.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,25QFC@186804|Peptostreptococcaceae 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k141_234_42 1035196.HMPREF9998_01417 3.95e-107 313.0 COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,25QQZ@186804|Peptostreptococcaceae 186801|Clostridia OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k141_234_43 1286171.EAL2_c16290 1.15e-145 428.0 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,25VD0@186806|Eubacteriaceae 186801|Clostridia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k141_234_44 1408422.JHYF01000010_gene3343 4.01e-52 171.0 COG4843@1|root,COG4843@2|Bacteria,1V14J@1239|Firmicutes,24J7S@186801|Clostridia,36IGD@31979|Clostridiaceae 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 k141_73_10 1292035.H476_0804 1.16e-202 583.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,25SEU@186804|Peptostreptococcaceae 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k141_73_11 350688.Clos_1342 1.12e-36 140.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component appB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k141_73_12 1408254.T458_18700 5.03e-43 156.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,274TA@186822|Paenibacillaceae 91061|Bacilli EP Peptide ABC transporter permease - - - - - - - - - - - - BPD_transp_1,OppC_N k141_73_14 1121324.CLIT_16c00140 7.17e-88 270.0 COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,25M4G@186801|Clostridia,25RIT@186804|Peptostreptococcaceae 186801|Clostridia M Mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k141_73_18 1121324.CLIT_10c01080 1.23e-27 102.0 2E5UQ@1|root,330IY@2|Bacteria,1VI50@1239|Firmicutes,24QVH@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_73_19 1262449.CP6013_3705 1.97e-76 246.0 COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,248B2@186801|Clostridia,36HRR@31979|Clostridiaceae 186801|Clostridia S PFAM transposase YhgA family protein - - - - - - - - - - - - DUF4351,Transposase_31 k141_73_21 1380408.AVGH01000004_gene2326 2.14e-84 259.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,21V0J@150247|Anoxybacillus 91061|Bacilli K DeoR C terminal sensor domain fruR - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k141_73_22 536227.CcarbDRAFT_0919 3.53e-104 313.0 COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia,36DV1@31979|Clostridiaceae 186801|Clostridia H Belongs to the carbohydrate kinase PfkB family. LacC subfamily pfkB - 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k141_26_9 720554.Clocl_0167 6.82e-81 252.0 COG1149@1|root,COG1149@2|Bacteria,1TP7Y@1239|Firmicutes,249ER@186801|Clostridia,3WMUC@541000|Ruminococcaceae 186801|Clostridia C CobQ/CobB/MinD/ParA nucleotide binding domain - - - - - - - - - - - - CbiA,Fer4,ParA k141_26_10 398512.JQKC01000001_gene2289 8.35e-26 100.0 COG1433@1|root,COG1433@2|Bacteria,1VFDZ@1239|Firmicutes,24R8N@186801|Clostridia,3WM0B@541000|Ruminococcaceae 186801|Clostridia S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k141_26_11 1291050.JAGE01000002_gene3888 3.05e-99 303.0 COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,3WGBQ@541000|Ruminococcaceae 186801|Clostridia D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - - - - - - - - - - Nitro_FeMo-Co,ParA k141_26_12 1449063.JMLS01000029_gene515 6.26e-40 136.0 COG2201@1|root,COG2201@2|Bacteria 2|Bacteria NT protein-glutamate methylesterase activity cheB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k141_26_13 1304284.L21TH_0079 0.0 1526.0 COG1057@1|root,COG1057@2|Bacteria,1TQVJ@1239|Firmicutes,249M0@186801|Clostridia,36DM4@31979|Clostridiaceae 186801|Clostridia H Cytidylyltransferase-like - - - - - - - - - - - - CTP_transf_like k141_26_14 536227.CcarbDRAFT_2863 4.07e-87 278.0 COG0039@1|root,COG0039@2|Bacteria,1TQIV@1239|Firmicutes,248DK@186801|Clostridia,36GJF@31979|Clostridiaceae 186801|Clostridia C lactate/malate dehydrogenase, NAD binding domain - - - - - - - - - - - - Ldh_1_N k141_26_15 941824.TCEL_01683 8.48e-106 321.0 COG0431@1|root,COG0431@2|Bacteria,1UYKJ@1239|Firmicutes,2485E@186801|Clostridia,36E7N@31979|Clostridiaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k141_26_16 272563.CD630_25250 2.07e-29 114.0 COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24KZH@186801|Clostridia,25RI7@186804|Peptostreptococcaceae 186801|Clostridia S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k141_26_17 536227.CcarbDRAFT_3209 2.95e-35 139.0 COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,25AZS@186801|Clostridia,36ECN@31979|Clostridiaceae 186801|Clostridia T PFAM metal-dependent phosphohydrolase HD sub domain - - - - - - - - - - - - HD,HD_5 k141_26_18 1410622.JNKY01000012_gene2093 0.000199 43.5 COG1925@1|root,COG1925@2|Bacteria,1TTT1@1239|Firmicutes,24PF9@186801|Clostridia,27PIE@186928|unclassified Lachnospiraceae 186801|Clostridia G PTS HPr component phosphorylation site - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k141_26_19 332101.JIBU02000023_gene4770 0.0 1045.0 COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,36E5W@31979|Clostridiaceae 186801|Clostridia G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k141_26_20 1408439.JHXW01000002_gene474 7.48e-195 557.0 COG0297@1|root,COG0297@2|Bacteria,378FM@32066|Fusobacteria 32066|Fusobacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k141_26_21 1391646.AVSU01000017_gene3102 3.5e-101 311.0 COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia,25QUP@186804|Peptostreptococcaceae 186801|Clostridia G Glucose-1-phosphate adenylyltransferase, GlgD subunit glgD - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k141_26_22 290402.Cbei_4905 2e-168 482.0 COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,36DKC@31979|Clostridiaceae 186801|Clostridia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k141_26_23 1121324.CLIT_5c00440 2.02e-281 791.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,25QUV@186804|Peptostreptococcaceae 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k141_26_24 1408304.JAHA01000008_gene1658 3.15e-62 221.0 COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,4BWP8@830|Butyrivibrio 186801|Clostridia O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k141_26_25 1280664.AUIX01000022_gene1427 5.75e-62 216.0 COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,4BXA8@830|Butyrivibrio 186801|Clostridia T GHKL domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_26_26 929506.CbC4_0146 2.4e-86 262.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,36EQW@31979|Clostridiaceae 186801|Clostridia KT response regulator resD - - ko:K07668,ko:K07775 ko02020,map02020 M00458,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_26_28 484770.UFO1_1632 2.51e-84 262.0 COG1732@1|root,COG1732@2|Bacteria,1TQ7D@1239|Firmicutes,4H29N@909932|Negativicutes 909932|Negativicutes P ABC transporter, substrate-binding protein, QAT family proWX - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k141_26_29 1511.CLOST_1010 1.59e-162 471.0 COG3263@1|root,COG3263@2|Bacteria,1TQPJ@1239|Firmicutes,2486W@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Na_H_Exchanger k141_26_30 1033737.CAEV01000022_gene3301 6.41e-91 268.0 2C91C@1|root,30CC5@2|Bacteria,1V1Z2@1239|Firmicutes,24HJH@186801|Clostridia,36IUN@31979|Clostridiaceae 186801|Clostridia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C k141_26_31 293826.Amet_3721 6.16e-83 260.0 COG1275@1|root,COG1275@2|Bacteria,1UYTE@1239|Firmicutes,2497H@186801|Clostridia,36FBE@31979|Clostridiaceae 186801|Clostridia P Voltage-dependent anion channel - - - ko:K11041 ko05150,map05150 - - - ko00000,ko00001,ko02042 2.A.16 - - SLAC1 k141_26_32 189425.PGRAT_24935 4.97e-41 146.0 COG0675@1|root,COG0675@2|Bacteria,1TT4J@1239|Firmicutes,4HEKB@91061|Bacilli,26UMB@186822|Paenibacillaceae 91061|Bacilli L Putative transposase DNA-binding domain - - - - - - - - - - - - OrfB_IS605,OrfB_Zn_ribbon k141_77_1 1499689.CCNN01000009_gene2722 2.88e-249 699.0 COG2978@1|root,COG2978@2|Bacteria,1TPDU@1239|Firmicutes,24BJ1@186801|Clostridia,36DFI@31979|Clostridiaceae 186801|Clostridia H AbgT putative transporter family ydaH - - ko:K12942 - - - - ko00000 - - - ABG_transport k141_77_2 1476973.JMMB01000007_gene2379 3.19e-135 396.0 COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,25SQ5@186804|Peptostreptococcaceae 186801|Clostridia E Alanine racemase, N-terminal domain orr GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0036094,GO:0036361,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0048037,GO:0050157,GO:0070279,GO:0070280,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901605 5.1.1.12 ko:K21898 ko00472,map00472 - R00672 RC00302 ko00000,ko00001,ko01000 - - - Ala_racemase_N k141_77_3 1408422.JHYF01000001_gene2736 5.76e-76 252.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae 186801|Clostridia KT Bacterial regulatory protein, Fis family - - - ko:K06714 - - - - ko00000,ko03000 - - - HTH_8,PAS,PAS_4,PAS_8,PAS_9,Sigma54_activat k141_77_4 350688.Clos_1700 2.29e-215 603.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,36EMY@31979|Clostridiaceae 186801|Clostridia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k141_77_5 1499684.CCNP01000020_gene2448 8.59e-44 155.0 COG2966@1|root,COG2966@2|Bacteria,1TSE8@1239|Firmicutes,24A25@186801|Clostridia,36EA1@31979|Clostridiaceae 186801|Clostridia S hmm pf06738 - - - - - - - - - - - - ThrE k141_77_6 1121324.CLIT_23c02060 5.54e-47 156.0 COG3610@1|root,COG3610@2|Bacteria,1V6P0@1239|Firmicutes,24R80@186801|Clostridia,25TPA@186804|Peptostreptococcaceae 186801|Clostridia S Putative threonine/serine exporter - - - - - - - - - - - - ThrE_2 k141_77_7 1511.CLOST_1299 2.7e-26 103.0 COG3086@1|root,COG3086@2|Bacteria,1VEYP@1239|Firmicutes,25JYF@186801|Clostridia,25TX2@186804|Peptostreptococcaceae 186801|Clostridia T Positive regulator of sigma(E), RseC/MucC - - - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k141_77_8 509191.AEDB02000067_gene795 1.24e-28 106.0 COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia,3WJZ3@541000|Ruminococcaceae 186801|Clostridia S Metal-sensitive transcriptional repressor csoR - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k141_77_10 1292035.H476_0484 1.72e-301 837.0 COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,25QPR@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA-synt_2d,tRNA_anti-codon k141_77_11 1292035.H476_0482 4.82e-170 494.0 COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,25QG9@186804|Peptostreptococcaceae 186801|Clostridia H coproporphyrinogen III oxidase hemZ - - - - - - - - - - - Radical_SAM k141_77_12 632245.CLP_1327 4.03e-51 171.0 COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,36I3Z@31979|Clostridiaceae 186801|Clostridia S domain protein - - - - - - - - - - - - Lactamase_B k141_77_13 984262.SGRA_1815 2.68e-51 167.0 COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes,1ISI6@117747|Sphingobacteriia 976|Bacteroidetes J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k141_77_14 1511.CLOST_1305 0.0 1004.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,25QRM@186804|Peptostreptococcaceae 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS k141_77_15 1151292.QEW_3360 5.43e-86 256.0 COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,25RA2@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k141_77_16 445973.CLOBAR_01164 1.23e-171 522.0 COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25QXQ@186804|Peptostreptococcaceae 186801|Clostridia L exonuclease recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1,ssDNA-exonuc_C k141_77_17 1511.CLOST_1309 1.02e-116 344.0 COG0341@1|root,COG0341@2|Bacteria,1UHX8@1239|Firmicutes 1239|Firmicutes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA - - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF k141_77_18 1121324.CLIT_5c01000 2.33e-187 533.0 COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,25SH1@186804|Peptostreptococcaceae 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k141_77_19 1286171.EAL2_c09700 2.75e-63 199.0 COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia,25W8Q@186806|Eubacteriaceae 186801|Clostridia S Bacterial transferase hexapeptide repeat protein - - - - - - - - - - - - Hexapep,Hexapep_2 k141_77_20 596315.HMPREF0634_0329 4.54e-238 665.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,25QV7@186804|Peptostreptococcaceae 186801|Clostridia C Six-Cys-in-45 modification radical SAM protein scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k141_77_22 1408823.AXUS01000008_gene2284 1.27e-14 70.5 COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,25RND@186804|Peptostreptococcaceae 186801|Clostridia U Preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k141_77_23 674977.VMC_16750 8.1e-27 124.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XUI8@135623|Vibrionales 135623|Vibrionales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_77_24 1476973.JMMB01000007_gene672 4.15e-228 633.0 COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,25QE3@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k141_77_25 929506.CbC4_1055 1.5e-170 484.0 COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,36E77@31979|Clostridiaceae 186801|Clostridia J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k141_77_26 1471459.JFLJ01000137_gene1206 3.69e-47 178.0 COG2385@1|root,COG2385@2|Bacteria,1G2FP@1117|Cyanobacteria,1MKZ4@1212|Prochloraceae 1117|Cyanobacteria D sporulation protein spoIID - - ko:K06381 - - - - ko00000 - - - SpoIID k141_77_27 500633.CLOHIR_00905 7.12e-153 440.0 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,25QWA@186804|Peptostreptococcaceae 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k141_77_28 994573.T472_0212220 2.63e-25 104.0 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,36IEQ@31979|Clostridiaceae 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k141_77_29 525282.HMPREF0391_11809 1.15e-35 127.0 COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24NZG@186801|Clostridia,22H7H@1570339|Peptoniphilaceae 186801|Clostridia K Belongs to the Fur family - - - ko:K03711,ko:K09825 - - - - ko00000,ko03000 - - - FUR k141_77_30 1415775.U729_2396 2.27e-180 532.0 COG1193@1|root,COG1193@2|Bacteria,1TQWB@1239|Firmicutes,24A15@186801|Clostridia,36F5M@31979|Clostridiaceae 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS5 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V k141_77_31 768710.DesyoDRAFT_3994 1.32e-10 65.9 COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24QK6@186801|Clostridia,2635E@186807|Peptococcaceae 186801|Clostridia K PFAM Helix-turn-helix - - - - - - - - - - - - HTH_19,HTH_3 k141_77_32 1243664.CAVL020000045_gene2137 9.51e-109 321.0 COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,4HB4C@91061|Bacilli,1ZFF1@1386|Bacillus 91061|Bacilli E YoaP-like - - - - - - - - - - - - Acetyltransf_1,YoaP k141_77_33 1033810.HLPCO_000210 5.51e-51 172.0 COG5482@1|root,COG5482@2|Bacteria 2|Bacteria S Putative PD-(D/E)XK phosphodiesterase (DUF2161) MA20_28540 - - - - - - - - - - - DUF2161 k141_77_35 871968.DESME_07635 5.09e-28 103.0 COG1923@1|root,COG1923@2|Bacteria,1VEGI@1239|Firmicutes,24QIM@186801|Clostridia,262GK@186807|Peptococcaceae 186801|Clostridia J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k141_77_36 1408823.AXUS01000031_gene1605 2.4e-118 350.0 COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,25QWB@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k141_77_37 1121324.CLIT_11c02780 6.39e-164 498.0 COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,25R29@186804|Peptostreptococcaceae 186801|Clostridia L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k141_77_38 500633.CLOHIR_00552 0.0 988.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,25QVT@186804|Peptostreptococcaceae 186801|Clostridia L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k141_77_39 272563.CD630_19860 6e-216 610.0 COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,25R5Z@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k141_27_2 1292035.H476_1064 1.56e-79 243.0 COG0778@1|root,COG0778@2|Bacteria,1V2D6@1239|Firmicutes,25B91@186801|Clostridia,25RNX@186804|Peptostreptococcaceae 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k141_27_3 1321778.HMPREF1982_04275 1.67e-256 712.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,267P5@186813|unclassified Clostridiales 186801|Clostridia J tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k141_27_4 1384057.CD33_01515 6.69e-39 151.0 COG5279@1|root,COG5279@2|Bacteria,1UMNK@1239|Firmicutes,4IV59@91061|Bacilli,3J073@400634|Lysinibacillus 91061|Bacilli D Domain of unknown function (DUF5050) - - - - - - - - - - - - DUF5050,Transglut_core k141_28_3 1005048.CFU_2247 1.55e-11 69.3 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,2VI40@28216|Betaproteobacteria,472IR@75682|Oxalobacteraceae 28216|Betaproteobacteria U TIGRFAM adhesin HecA family 20-residue repeat (two copies), filamentous hemagglutinin family N-terminal domain fhaB - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act k141_28_4 1220589.CD32_12590 1.2e-17 78.6 2DI9P@1|root,302G7@2|Bacteria,1U39C@1239|Firmicutes,4IADA@91061|Bacilli,3J00I@400634|Lysinibacillus 91061|Bacilli - - - - - - - - - - - - - - - k141_28_5 66692.ABC3804 9.69e-47 170.0 COG3209@1|root,COG5444@1|root,COG3209@2|Bacteria,COG5444@2|Bacteria,1V54A@1239|Firmicutes,4HI4F@91061|Bacilli 91061|Bacilli M nuclease activity - - - - - - - - - - - - EndoU_bacteria k141_31_2 1195236.CTER_3582 2e-34 147.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 k141_208_1 1178540.BA70_12090 2.1e-16 85.1 COG2199@1|root,COG3706@2|Bacteria,1VHAN@1239|Firmicutes,4HQWC@91061|Bacilli,1ZFFR@1386|Bacillus 91061|Bacilli T Diguanylate cyclase, GGDEF domain ydaK - - - - - - - - - - - GGDEF k141_208_3 1121324.CLIT_14c00880 1.81e-169 488.0 COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,25BAQ@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase family 2 ydaM - 2.4.1.336 ko:K19003 ko00561,ko01100,map00561,map01100 - R02689 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT2 - Glyco_tranf_2_3,Glycos_transf_2 k141_208_4 1031288.AXAA01000026_gene249 3.78e-44 177.0 28HGC@1|root,2Z7S8@2|Bacteria,1V3ZA@1239|Firmicutes,25DSN@186801|Clostridia,36UEG@31979|Clostridiaceae 186801|Clostridia S Bacterial cellulose synthase subunit - - - - - - - - - - - - BcsB,SPOR k141_208_5 1487921.DP68_09850 4.81e-102 306.0 COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,36DKI@31979|Clostridiaceae 186801|Clostridia C Radical SAM - - - - - - - - - - - - Radical_SAM k141_208_6 634498.mru_1013 2.39e-62 215.0 COG2081@1|root,arCOG00575@2157|Archaea,2XWX6@28890|Euryarchaeota,23NYK@183925|Methanobacteria 183925|Methanobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k141_208_7 1123009.AUID01000005_gene1604 7.44e-85 254.0 COG2406@1|root,COG2406@2|Bacteria,1VD9N@1239|Firmicutes,24Q5S@186801|Clostridia 186801|Clostridia S Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k141_208_8 386415.NT01CX_0993 8.26e-27 99.8 2DN7S@1|root,32UIG@2|Bacteria,1VD9D@1239|Firmicutes,24NPR@186801|Clostridia,36MBJ@31979|Clostridiaceae 186801|Clostridia K Helix-turn-helix - - - - - - - - - - - - HTH_19,HTH_3 k141_208_9 326297.Sama_2880 4.77e-19 99.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMV2@1236|Gammaproteobacteria,2Q914@267890|Shewanellaceae 1236|Gammaproteobacteria T PFAM histidine kinase, HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_2,sCache_2 k141_208_10 1121324.CLIT_16c00200 2.61e-79 273.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_208_12 536227.CcarbDRAFT_3709 3.02e-117 369.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae 186801|Clostridia C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k141_208_15 330214.NIDE0992 6.19e-65 210.0 COG1039@1|root,COG1039@2|Bacteria 2|Bacteria L RNA-DNA hybrid ribonuclease activity rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03471 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DUF3378,RNase_HII k141_243_198 1151292.QEW_1624 1.76e-96 288.0 COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,25QZ3@186804|Peptostreptococcaceae 186801|Clostridia J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k141_243_199 1121324.CLIT_23c04190 1.99e-132 389.0 COG1243@1|root,COG1243@2|Bacteria,1TS1F@1239|Firmicutes,248YV@186801|Clostridia,25QV2@186804|Peptostreptococcaceae 186801|Clostridia BK Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,Radical_SAM_C k141_243_200 1151292.QEW_1626 5.92e-236 714.0 COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,25QTR@186804|Peptostreptococcaceae 186801|Clostridia D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k141_243_201 445973.CLOBAR_02210 1.99e-150 441.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,25R1C@186804|Peptostreptococcaceae 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k141_243_202 1301100.HG529233_gene7433 3.77e-36 127.0 COG2739@1|root,COG2739@2|Bacteria,1VEGP@1239|Firmicutes,24QNM@186801|Clostridia,36MJ0@31979|Clostridiaceae 186801|Clostridia S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein - - - ko:K09787 - - - - ko00000 - - - UPF0122 k141_243_203 1121324.CLIT_23c04230 3.41e-232 649.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,25QUD@186804|Peptostreptococcaceae 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k141_243_204 500633.CLOHIR_01175 1.2e-39 132.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,25RNI@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k141_243_205 1286171.EAL2_c12320 3.78e-33 115.0 COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,25X88@186806|Eubacteriaceae 186801|Clostridia S Belongs to the UPF0109 family ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 k141_243_206 1347392.CCEZ01000043_gene296 2.18e-39 138.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,36IPC@31979|Clostridiaceae 186801|Clostridia J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k141_243_207 1408422.JHYF01000001_gene2955 7.94e-94 282.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,36EJ7@31979|Clostridiaceae 186801|Clostridia J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k141_243_208 1511.CLOST_1575 3.48e-58 182.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,25RJR@186804|Peptostreptococcaceae 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k141_243_209 1408422.JHYF01000001_gene2957 1.4e-124 365.0 COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia,36DQN@31979|Clostridiaceae 186801|Clostridia S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity ylqF - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 k141_243_210 926692.AZYG01000059_gene113 1.46e-80 250.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,3WAMH@53433|Halanaerobiales 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k141_243_212 755731.Clo1100_1808 8.07e-17 76.6 COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia,36NNP@31979|Clostridiaceae 186801|Clostridia N cytoplasmic domain of flagellar protein FhlB flhB1 - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 k141_243_213 511680.BUTYVIB_00036 2.31e-18 81.3 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,4BZWV@830|Butyrivibrio 186801|Clostridia L Uncharacterised protein family UPF0102 - - - ko:K07460 - - - - ko00000 - - - UPF0102 k141_243_214 1391646.AVSU01000050_gene1742 9.9e-197 564.0 COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,25QJ8@186804|Peptostreptococcaceae 186801|Clostridia O Mg chelatase-like protein comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k141_243_215 1415775.U729_391 1.68e-86 263.0 COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia,36EDV@31979|Clostridiaceae 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, beta subunit sdaAB - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - ACT,SDH_beta k141_243_216 536232.CLM_1370 3.54e-129 376.0 COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia,36DCQ@31979|Clostridiaceae 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, alpha subunit sdaAA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha k141_243_217 536232.CLM_1396 2.38e-167 477.0 COG1299@1|root,COG1299@2|Bacteria,1UHP0@1239|Firmicutes,25EQ6@186801|Clostridia,36UR6@31979|Clostridiaceae 186801|Clostridia G Phosphotransferase system, EIIC - - - - - - - - - - - - PTS_EIIC_2 k141_243_223 485916.Dtox_0557 1.78e-78 251.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,260WJ@186807|Peptococcaceae 186801|Clostridia U Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k141_243_224 1444309.JAQG01000080_gene4024 5.54e-43 154.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,4HETN@91061|Bacilli,26TUB@186822|Paenibacillaceae 91061|Bacilli HP ABC transporter fecE - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k141_243_225 1150621.SMUL_1551 1.99e-100 304.0 COG4822@1|root,COG4822@2|Bacteria,1P36Y@1224|Proteobacteria,42P9C@68525|delta/epsilon subdivisions 1224|Proteobacteria H Catalyzes the insertion of Co(2 ) into sirohydrochlorin cbiK GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016852,GO:0020037,GO:0022607,GO:0042597,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050897,GO:0051259,GO:0051262,GO:0051266,GO:0065003,GO:0071840,GO:0097159,GO:1901363 4.99.1.3 ko:K02190 ko00860,ko01100,map00860,map01100 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiK k141_243_226 1321778.HMPREF1982_03472 2.83e-86 268.0 COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia 186801|Clostridia P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k141_243_227 927704.SELR_07230 3.22e-64 210.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4H28S@909932|Negativicutes 909932|Negativicutes V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_243_228 865861.AZSU01000003_gene2238 2.38e-95 286.0 COG0842@1|root,COG0842@2|Bacteria,1TSWD@1239|Firmicutes,24DHH@186801|Clostridia,36INU@31979|Clostridiaceae 186801|Clostridia V ABC-2 type transporter yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k141_243_229 1286171.EAL2_c12430 5.47e-98 303.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,25VKT@186806|Eubacteriaceae 186801|Clostridia LU DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k141_243_230 1121324.CLIT_23c04430 0.0 948.0 COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,25R1U@186804|Peptostreptococcaceae 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k141_243_232 1121324.CLIT_23c04440 5.73e-141 403.0 COG4465@1|root,COG4465@2|Bacteria,1TS7A@1239|Firmicutes,2480R@186801|Clostridia,25QEE@186804|Peptostreptococcaceae 186801|Clostridia K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor codY - - ko:K03706 - - - - ko00000,ko03000 - - - CodY,HTH_CodY k141_243_233 37659.JNLN01000001_gene2612 2.68e-172 495.0 COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,36EXD@31979|Clostridiaceae 186801|Clostridia L AAA ATPase yrvN - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k141_243_234 1286171.EAL2_c12470 0.0 1667.0 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,25ZK1@186806|Eubacteriaceae 186801|Clostridia C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS18410 Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k141_243_235 293826.Amet_2452 4.34e-56 179.0 COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,36J5P@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator iscR - - - - - - - - - - - Rrf2 k141_243_236 1301100.HG529236_gene7241 7.92e-201 565.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k141_243_237 1151292.QEW_1657 1.45e-77 233.0 COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,25RDC@186804|Peptostreptococcaceae 186801|Clostridia C NifU-like N terminal domain nifU - - ko:K04488 - - - - ko00000 - - - NifU_N k141_243_238 1286171.EAL2_c12510 4.57e-171 487.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,25VKX@186806|Eubacteriaceae 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k141_243_239 1286171.EAL2_c12520 0.0 1102.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,25V3M@186806|Eubacteriaceae 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k141_243_240 478749.BRYFOR_07761 3.2e-29 106.0 COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia 186801|Clostridia S Belongs to the UPF0297 family yrzL - - - - - - - - - - - DUF965 k141_243_241 1121324.CLIT_23c04530 3.5e-160 486.0 COG3119@1|root,COG3119@2|Bacteria,1TSMM@1239|Firmicutes,247YU@186801|Clostridia,25QS7@186804|Peptostreptococcaceae 186801|Clostridia P arylsulfatase activity - - - - - - - - - - - - - k141_243_242 1511.CLOST_1488 1.24e-124 366.0 COG0667@1|root,COG1145@1|root,COG0667@2|Bacteria,COG1145@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia 186801|Clostridia C PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red,Fer4 k141_243_243 445973.CLOBAR_02182 3.99e-58 184.0 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,25RGT@186804|Peptostreptococcaceae 186801|Clostridia J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k141_243_244 350688.Clos_1662 7.79e-16 72.8 COG3906@1|root,COG3906@2|Bacteria,1VF5Z@1239|Firmicutes 1239|Firmicutes S Belongs to the UPF0473 family - - - - - - - - - - - - DUF1292 k141_243_245 1121324.CLIT_23c04560 2.18e-28 103.0 COG1918@1|root,COG1918@2|Bacteria,1VEQU@1239|Firmicutes,24R31@186801|Clostridia 186801|Clostridia P PFAM FeoA family protein - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k141_243_246 1121324.CLIT_23c04570 2.76e-295 823.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k141_243_248 796940.HMPREF9628_01987 7.64e-60 189.0 COG0735@1|root,COG0735@2|Bacteria,1V7F0@1239|Firmicutes,24JQE@186801|Clostridia,25RK9@186804|Peptostreptococcaceae 186801|Clostridia P Ferric uptake regulator family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k141_243_249 1286171.EAL2_c12580 2.26e-306 846.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,25V02@186806|Eubacteriaceae 186801|Clostridia J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k141_243_250 1511.CLOST_1481 7.55e-59 190.0 COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,25RKB@186804|Peptostreptococcaceae 186801|Clostridia S Peptidase, M50 family ywhC - - - - - - - - - - - Peptidase_M50 k141_243_251 1391646.AVSU01000027_gene2413 8.95e-49 167.0 COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,25RMB@186804|Peptostreptococcaceae 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k141_243_252 1121324.CLIT_23c04620 4.04e-62 197.0 COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,25RCC@186804|Peptostreptococcaceae 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k141_243_253 1511.CLOST_1478 8.13e-90 267.0 COG1396@1|root,COG1396@2|Bacteria,1V1K5@1239|Firmicutes,24FTC@186801|Clostridia,25R2E@186804|Peptostreptococcaceae 186801|Clostridia K AraC-like ligand binding domain puuR - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 k141_243_254 1230342.CTM_07461 4.98e-95 285.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,36EH3@31979|Clostridiaceae 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k141_243_256 1111732.AZOD01000012_gene1305 2.46e-33 125.0 COG2519@1|root,COG2519@2|Bacteria,1QX2B@1224|Proteobacteria,1T5KY@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Putative rRNA methylase - - - - - - - - - - - - rRNA_methylase k141_243_257 688269.Theth_1049 6.86e-61 199.0 COG0496@1|root,COG0496@2|Bacteria,2GC9F@200918|Thermotogae 200918|Thermotogae F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k141_243_258 1123009.AUID01000036_gene1243 7.53e-29 104.0 COG1146@1|root,COG1146@2|Bacteria,1VFGN@1239|Firmicutes,25FSQ@186801|Clostridia 186801|Clostridia C PFAM 4Fe-4S - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Fer4_9 k141_243_259 1123009.AUID01000036_gene1242 3.99e-203 570.0 COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,26ANE@186813|unclassified Clostridiales 186801|Clostridia C Pyruvate:ferredoxin oxidoreductase core domain II korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k141_243_260 1123009.AUID01000036_gene1241 2.05e-167 471.0 COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,26A2N@186813|unclassified Clostridiales 186801|Clostridia C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k141_243_261 1408422.JHYF01000016_gene126 3.02e-65 204.0 COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,24I3Y@186801|Clostridia,36IU6@31979|Clostridiaceae 186801|Clostridia C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k141_243_262 1121324.CLIT_23c04660 6.18e-159 451.0 COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,25QFH@186804|Peptostreptococcaceae 186801|Clostridia K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS k141_243_263 469618.FVAG_00474 2.82e-159 471.0 COG1306@1|root,COG1306@2|Bacteria,379EF@32066|Fusobacteria 32066|Fusobacteria S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 k141_243_264 445973.CLOBAR_01040 1.99e-155 447.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,25QEJ@186804|Peptostreptococcaceae 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 k141_243_265 1511.CLOST_1747 4.38e-127 369.0 COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,25QQU@186804|Peptostreptococcaceae 186801|Clostridia P ABC transporter permease potB - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k141_243_266 546269.HMPREF0389_00718 3.27e-106 315.0 COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia,25QHZ@186804|Peptostreptococcaceae 186801|Clostridia P ABC transporter permease - - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k141_243_267 1511.CLOST_1745 9.99e-165 470.0 COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,25R00@186804|Peptostreptococcaceae 186801|Clostridia P Bacterial extracellular solute-binding protein potD - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1,SBP_bac_6,SBP_bac_8 k141_243_268 999423.HMPREF9161_01744 2.49e-10 62.0 COG1815@1|root,COG1815@2|Bacteria,1VEUZ@1239|Firmicutes 1239|Firmicutes N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k141_243_269 1511.CLOST_1743 1.22e-54 175.0 COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,25TJT@186804|Peptostreptococcaceae 186801|Clostridia N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k141_243_270 1286171.EAL2_c13700 2.92e-20 85.1 COG1677@1|root,COG1677@2|Bacteria,1UG7J@1239|Firmicutes,25NGB@186801|Clostridia,25XGJ@186806|Eubacteriaceae 186801|Clostridia N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE k141_243_271 1286171.EAL2_c13690 1.64e-131 399.0 COG1766@1|root,COG1766@2|Bacteria,1TRK0@1239|Firmicutes,2498Q@186801|Clostridia,25WPD@186806|Eubacteriaceae 186801|Clostridia N Flagellar M-ring protein fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k141_243_272 1121324.CLIT_11c01890 5.52e-180 508.0 COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia 186801|Clostridia N Flagellar motor switch protein flig fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k141_243_273 1121324.CLIT_11c01900 8.07e-33 129.0 COG1317@1|root,COG1317@2|Bacteria 2|Bacteria N bacterial-type flagellum organization fliH - - ko:K02411,ko:K03223 ko02040,ko03070,map02040,map03070 M00332,M00660 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 - - FliH k141_243_274 1511.CLOST_1738 3.7e-242 674.0 COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,25S4K@186804|Peptostreptococcaceae 186801|Clostridia NU ATP synthase alpha/beta family, beta-barrel domain fliI - 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k141_243_275 1408321.JNJD01000006_gene897 3.73e-06 51.6 COG2882@1|root,COG2882@2|Bacteria,1VK96@1239|Firmicutes,24RWK@186801|Clostridia,27NTH@186928|unclassified Lachnospiraceae 186801|Clostridia NOU Flagellar FliJ protein fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ k141_243_277 864565.HMPREF0379_0460 1.28e-09 68.9 COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24UIZ@186801|Clostridia 186801|Clostridia N PFAM flagellar hook-length control - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k141_243_278 608506.COB47_1947 2.23e-17 82.0 COG1843@1|root,COG1843@2|Bacteria,1VF85@1239|Firmicutes,24QKD@186801|Clostridia,42HFM@68295|Thermoanaerobacterales 186801|Clostridia N PFAM flagellar hook capping protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD k141_243_279 1410625.JHWK01000003_gene1824 3.34e-62 218.0 COG1749@1|root,COG1749@2|Bacteria,1UHS7@1239|Firmicutes,247ZT@186801|Clostridia,27I5I@186928|unclassified Lachnospiraceae 186801|Clostridia N Flagellar basal body rod FlgEFG protein C-terminal flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k141_243_280 1121324.CLIT_11c01970 1.22e-15 70.9 COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia 186801|Clostridia N PFAM flagellar FlbD family protein flbD - - ko:K02385 - - - - ko00000,ko02035 - - - FlbD k141_243_281 1511.CLOST_1731 2.71e-118 345.0 COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia,25S1P@186804|Peptostreptococcaceae 186801|Clostridia N MotA/TolQ/ExbB proton channel family motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k141_243_282 999411.HMPREF1092_01494 4.38e-42 151.0 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,36FHM@31979|Clostridiaceae 186801|Clostridia N PFAM OmpA MotB domain protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k141_243_283 1286171.EAL2_c13570 2.17e-34 123.0 COG1580@1|root,COG1580@2|Bacteria 2|Bacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k141_243_284 1121324.CLIT_11c02010 1.65e-168 479.0 COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia 186801|Clostridia N flagellar motor switch protein FliM fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k141_243_285 1286171.EAL2_c13550 3.87e-137 404.0 COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia,25VY6@186806|Eubacteriaceae 186801|Clostridia N Type III flagellar switch regulator (C-ring) FliN C-term fliN - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - CheC,FliMN_C k141_243_286 1121289.JHVL01000003_gene2214 3.95e-71 215.0 COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,24HJF@186801|Clostridia,36IRR@31979|Clostridiaceae 186801|Clostridia NT Chemotaxis protein cheY cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k141_243_288 1121324.CLIT_11c02050 3.1e-97 291.0 COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,25STK@186804|Peptostreptococcaceae 186801|Clostridia N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k141_243_289 1121324.CLIT_11c02060 5.12e-31 111.0 COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,24QJR@186801|Clostridia,25TZT@186804|Peptostreptococcaceae 186801|Clostridia N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k141_243_290 1286171.EAL2_c13500 1.04e-56 189.0 COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,24ECW@186801|Clostridia,25WZS@186806|Eubacteriaceae 186801|Clostridia N flagellar biosynthetic protein FliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k141_243_291 1286171.EAL2_c13490 1.38e-122 364.0 COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,248N7@186801|Clostridia,25VUQ@186806|Eubacteriaceae 186801|Clostridia N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401,ko:K13820 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1,Bac_export_2 k141_162_5 1347392.CCEZ01000043_gene83 3.03e-79 247.0 COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,36EZP@31979|Clostridiaceae 186801|Clostridia ET Belongs to the bacterial solute-binding protein 3 family artP - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k141_162_6 1121423.JONT01000008_gene722 4.49e-102 311.0 COG4632@1|root,COG4632@2|Bacteria,1TP2R@1239|Firmicutes,249PA@186801|Clostridia 186801|Clostridia G Exopolysaccharide biosynthesis protein - - - - - - - - - - - - CW_binding_2,Cu_amine_oxidN1,NAGPA k141_162_8 1123020.AUIE01000011_gene1293 2.03e-24 108.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YIWT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,MASE3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k141_162_9 931276.Cspa_c03660 9.59e-120 358.0 COG0463@1|root,COG0463@2|Bacteria,1UE0C@1239|Firmicutes,249GE@186801|Clostridia,36HGZ@31979|Clostridiaceae 186801|Clostridia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k141_208_43 1121289.JHVL01000001_gene1877 1.02e-301 833.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae 186801|Clostridia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS01075 CTP_synth_N,GATase k141_208_44 1121324.CLIT_4c00090 3.89e-124 376.0 COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,25QD4@186804|Peptostreptococcaceae 186801|Clostridia M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,PG_binding_1,Peptidase_S41 k141_208_45 1121324.CLIT_2c03850 1.25e-51 186.0 COG0825@1|root,COG0825@2|Bacteria,1VFBH@1239|Firmicutes,24RR1@186801|Clostridia 186801|Clostridia I PFAM Copper amine - - - - - - - - - - - - Cu_amine_oxidN1 k141_208_46 1121324.CLIT_4c00070 6.51e-193 593.0 COG5492@1|root,COG5492@2|Bacteria,1VIXQ@1239|Firmicutes,25FMR@186801|Clostridia 186801|Clostridia N S-layer homology domain - - - - - - - - - - - - SLH k141_208_48 592027.CLG_B1549 2.34e-134 444.0 COG2247@1|root,COG2247@2|Bacteria,1UYS6@1239|Firmicutes,24ABJ@186801|Clostridia 186801|Clostridia M cell wall binding repeat - - - - - - - - - - - - - k141_208_56 1449126.JQKL01000051_gene3164 8.1e-128 377.0 28ISD@1|root,2Z8RJ@2|Bacteria,1TQJ7@1239|Firmicutes,2499A@186801|Clostridia,26API@186813|unclassified Clostridiales 186801|Clostridia S Phage tail sheath protein subtilisin-like domain - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k141_208_57 1294142.CINTURNW_0298 4.76e-39 136.0 2CCC9@1|root,32JA4@2|Bacteria,1V9J9@1239|Firmicutes,25HMV@186801|Clostridia,36UCV@31979|Clostridiaceae 186801|Clostridia S Phage tail tube protein - - - - - - - - - - - - DUF2001 k141_208_58 1401067.HMPREF0872_00250 1.26e-15 74.7 2CBYI@1|root,333M7@2|Bacteria 2|Bacteria S Phage XkdN-like tail assembly chaperone protein, TAC - - - - - - - - - - - - Phage_TAC_5 k141_208_61 1123239.KB898628_gene3244 4.49e-27 105.0 COG1652@1|root,COG1652@2|Bacteria,1VE0Z@1239|Firmicutes,4IUU2@91061|Bacilli 91061|Bacilli S LysM domain - - - - - - - - - - - - - k141_208_62 1449126.JQKL01000051_gene3158 2.97e-42 155.0 COG3500@1|root,COG3500@2|Bacteria 2|Bacteria - - - - - ko:K06905 - - - - ko00000 - - - - k141_208_64 1002809.SSIL_1436 4.62e-20 87.8 COG3628@1|root,COG3628@2|Bacteria,1VFFX@1239|Firmicutes 1239|Firmicutes S Protein of unknown function (DUF2634) - - - - - - - - - - - - DUF2634 k141_208_65 318464.IO99_13680 7.29e-45 164.0 COG3299@1|root,COG3299@2|Bacteria,1TQZU@1239|Firmicutes,249WP@186801|Clostridia,36FT3@31979|Clostridiaceae 186801|Clostridia S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k141_208_66 1145276.T479_01700 4.08e-17 78.6 2DQ74@1|root,3351A@2|Bacteria,1UNGY@1239|Firmicutes,4IUDZ@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k141_208_69 720555.BATR1942_09785 3.24e-21 90.1 COG4824@1|root,COG4824@2|Bacteria,1V3TR@1239|Firmicutes,4HQ4R@91061|Bacilli 91061|Bacilli S phage lysis holin - - - - - - - - - - - - Phage_holin_4_1 k141_208_72 1178540.BA70_01780 2.04e-80 265.0 COG5518@1|root,COG5518@2|Bacteria,1TT5R@1239|Firmicutes,4HEHM@91061|Bacilli,1ZE9D@1386|Bacillus 91061|Bacilli S portal protein yqbA - - - - - - - - - - - Phage_portal k141_208_73 1487921.DP68_08880 2.34e-41 155.0 COG0338@1|root,COG0338@2|Bacteria,1V1FT@1239|Firmicutes,250FC@186801|Clostridia 186801|Clostridia L Putative phage serine protease XkdF - - - - - - - - - - - - Peptidase_S78_2 k141_208_84 552396.HMPREF0863_00269 5.19e-24 117.0 COG5283@1|root,COG5283@2|Bacteria,1UHQM@1239|Firmicutes 1239|Firmicutes D Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail,Sipho_tail k141_208_86 1449050.JNLE01000005_gene4462 1.47e-10 72.0 COG0791@1|root,COG3103@1|root,COG0791@2|Bacteria,COG3103@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae 186801|Clostridia M NLP P60 protein - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3 k141_208_90 445335.CBN_3070 5.34e-59 204.0 2DVYI@1|root,32V0D@2|Bacteria,1VCV5@1239|Firmicutes,24A7F@186801|Clostridia,36GKX@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_208_102 1304284.L21TH_0521 1.71e-12 63.2 2DT75@1|root,33IZI@2|Bacteria,1U4C1@1239|Firmicutes,24VFM@186801|Clostridia,36U1B@31979|Clostridiaceae 186801|Clostridia S Helix-turn-helix domain - - - - - - - - - - - - HTH_16 k141_208_105 935837.JAEK01000020_gene600 2.08e-08 53.1 2DR75@1|root,33AHG@2|Bacteria,1VKH9@1239|Firmicutes,4HR4K@91061|Bacilli,1ZJ6X@1386|Bacillus 91061|Bacilli S Protein of unknown function (DUF1659) - - - - - - - - - - - - DUF1659 k141_208_106 332101.JIBU02000020_gene1990 5.34e-06 47.0 2DR42@1|root,33A2M@2|Bacteria,1VKCM@1239|Firmicutes,259C5@186801|Clostridia,36P1F@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF2922) - - - - - - - - - - - - DUF2922 k141_208_107 1121324.CLIT_4c00070 2.73e-36 150.0 COG5492@1|root,COG5492@2|Bacteria,1VIXQ@1239|Firmicutes,25FMR@186801|Clostridia 186801|Clostridia N S-layer homology domain - - - - - - - - - - - - SLH k141_208_108 1304284.L21TH_1865 1.73e-109 338.0 COG3206@1|root,COG3206@2|Bacteria,1TSJG@1239|Firmicutes,249MI@186801|Clostridia,36HXB@31979|Clostridiaceae 186801|Clostridia M G-rich domain on putative tyrosine kinase - - - - - - - - - - - - GNVR,Wzz k141_208_109 1121289.JHVL01000007_gene2818 1.83e-194 592.0 COG3063@1|root,COG3307@1|root,COG3063@2|Bacteria,COG3307@2|Bacteria,1TRQM@1239|Firmicutes,249I7@186801|Clostridia,36FS5@31979|Clostridiaceae 186801|Clostridia MNU O-Antigen ligase - - - - - - - - - - - - TPR_16,TPR_8,Wzy_C k141_208_110 203119.Cthe_2649 3.59e-129 374.0 COG2301@1|root,COG2301@2|Bacteria,1UNWU@1239|Firmicutes,24CR9@186801|Clostridia 186801|Clostridia C HpcH/HpaI aldolase/citrate lyase family - - - - - - - - - - - - HpcH_HpaI k141_208_111 1139219.I569_02278 1.98e-63 202.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,4HCBG@91061|Bacilli,4B0AX@81852|Enterococcaceae 91061|Bacilli M Bacterial sugar transferase - - - ko:K13012,ko:K19428 - - - - ko00000,ko01000,ko01005 - - - Bac_transf k141_208_112 406327.Mevan_0408 6.88e-129 376.0 COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,23QFV@183939|Methanococci 28890|Euryarchaeota E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k141_208_113 1284686.HMPREF1630_05975 4.45e-84 268.0 COG1215@1|root,COG1215@2|Bacteria,1TPY9@1239|Firmicutes,24E2E@186801|Clostridia,22GKG@1570339|Peptoniphilaceae 186801|Clostridia M Glycosyl transferase family 21 - - - - - - - - - - - - Glycos_transf_2 k141_208_114 1540257.JQMW01000011_gene1596 8.63e-172 491.0 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,36F9F@31979|Clostridiaceae 186801|Clostridia GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k141_208_115 445961.IW15_06225 2.14e-33 124.0 COG0110@1|root,COG0110@2|Bacteria,4NNQ5@976|Bacteroidetes,1I27N@117743|Flavobacteriia,3ZSVS@59732|Chryseobacterium 976|Bacteroidetes S catalyzes the transfer of the O-acetyl moiety to the O antigen - - - ko:K08280 - - - - ko00000,ko01000,ko01005 - - - Hexapep,Hexapep_2 k141_208_116 1123307.KB904377_gene325 2.02e-80 251.0 2E54Z@1|root,32ZXX@2|Bacteria,1VGRF@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k141_208_117 1064535.MELS_0816 1.28e-58 194.0 COG1216@1|root,COG1216@2|Bacteria,1V8VN@1239|Firmicutes 1239|Firmicutes S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k141_208_118 1268239.PALB_11410 1.42e-12 77.4 2DZXJ@1|root,32VMJ@2|Bacteria,1NV9R@1224|Proteobacteria,1SNHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k141_208_119 1031288.AXAA01000019_gene1062 3.28e-139 418.0 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,36FH2@31979|Clostridiaceae 186801|Clostridia S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k141_208_121 655812.HMPREF0061_0444 6.13e-183 512.0 COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli 91061|Bacilli M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k141_208_122 994573.T472_0204595 9.08e-259 718.0 COG1091@1|root,COG1898@1|root,COG1091@2|Bacteria,COG1898@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,36E2P@31979|Clostridiaceae 186801|Clostridia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k141_208_123 768706.Desor_5128 3.3e-204 571.0 COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,26192@186807|Peptococcaceae 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k141_208_124 1294265.JCM21738_3880 6e-228 634.0 COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,4HADP@91061|Bacilli,1ZAP3@1386|Bacillus 91061|Bacilli M Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd GO:0003674,GO:0003824,GO:0003979,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k141_208_125 469596.HMPREF9488_00419 1.99e-15 76.6 COG5652@1|root,COG5652@2|Bacteria,1VF6Q@1239|Firmicutes,3VRNT@526524|Erysipelotrichia 526524|Erysipelotrichia S VanZ like family - - - - - - - - - - - - VanZ k141_241_88 1511.CLOST_2318 7.02e-34 119.0 COG1436@1|root,COG1436@2|Bacteria,1VEN1@1239|Firmicutes,24K2E@186801|Clostridia,25RXM@186804|Peptostreptococcaceae 186801|Clostridia C ATP synthase (F/14-kDa) subunit - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F k141_241_90 1121324.CLIT_13c01040 4.4e-282 788.0 COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,25QTT@186804|Peptostreptococcaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit ntpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k141_241_91 1304284.L21TH_0587 5.29e-232 650.0 COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit ntpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k141_241_92 857293.CAAU_1875 5.2e-66 209.0 COG1394@1|root,COG1394@2|Bacteria,1TQ4P@1239|Firmicutes,24Z7J@186801|Clostridia,36WU0@31979|Clostridiaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k141_241_93 1511.CLOST_2313 7.1e-61 193.0 COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,25RKK@186804|Peptostreptococcaceae 186801|Clostridia J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE k141_241_94 65093.PCC7418_3088 3.14e-95 303.0 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria 1117|Cyanobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k141_241_96 941824.TCEL_01644 1.56e-142 410.0 COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae 186801|Clostridia M UTP-glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS02205 NTP_transferase k141_241_97 1007103.AFHW01000174_gene2480 5.06e-19 96.3 COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,4HEMZ@91061|Bacilli,26UMD@186822|Paenibacillaceae 91061|Bacilli M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k141_241_98 1121324.CLIT_13c01100 0.0 1370.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,25QT4@186804|Peptostreptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k141_241_99 1286171.EAL2_c03620 1.8e-69 231.0 COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,24H3M@186801|Clostridia 186801|Clostridia MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k141_241_100 350688.Clos_2601 1.84e-49 189.0 COG1404@1|root,COG1404@2|Bacteria,1UJN4@1239|Firmicutes,25F63@186801|Clostridia 186801|Clostridia O S-layer homology domain - - - - - - - - - - - - SLH k141_241_101 1122143.AUEG01000012_gene1719 0.000194 47.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,27FKB@186828|Carnobacteriaceae 91061|Bacilli T Transcriptional regulatory protein, C terminal phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_241_102 1121324.CLIT_13c01150 4.17e-114 331.0 COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,25QSS@186804|Peptostreptococcaceae 186801|Clostridia H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k141_195_12 572544.Ilyop_1601 4.02e-26 104.0 COG1149@1|root,COG1149@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding ldpA - - - - - - - - - - - Fer4,Fer4_6,LdpA_C k141_195_13 903814.ELI_1732 1.56e-79 246.0 COG1126@1|root,COG1126@2|Bacteria,1UZPS@1239|Firmicutes,249JK@186801|Clostridia 186801|Clostridia E ATPases associated with a variety of cellular activities - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k141_195_14 290402.Cbei_2511 1.87e-14 77.8 COG0765@1|root,COG0765@2|Bacteria,1TR7R@1239|Firmicutes,24823@186801|Clostridia,36DWH@31979|Clostridiaceae 186801|Clostridia P amino acid ABC transporter - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k141_195_15 903814.ELI_1730 3.01e-66 214.0 COG0834@1|root,COG0834@2|Bacteria,1V0E4@1239|Firmicutes,24CJC@186801|Clostridia,25X49@186806|Eubacteriaceae 186801|Clostridia ET Ligated ion channel L-glutamate- and glycine-binding site - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k141_195_16 1121324.CLIT_10c04330 6.54e-218 615.0 COG2897@1|root,COG2897@2|Bacteria,1TS7E@1239|Firmicutes,24CNW@186801|Clostridia,25SF2@186804|Peptostreptococcaceae 186801|Clostridia P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.11,2.8.1.2 ko:K01011,ko:K21028 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106,R07461 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k141_195_17 1232447.BAHW02000027_gene1915 3.66e-107 314.0 COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,267WQ@186813|unclassified Clostridiales 186801|Clostridia OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k141_195_18 445971.ANASTE_01776 9.71e-38 140.0 COG2768@1|root,COG2768@2|Bacteria,1V2K1@1239|Firmicutes,24FX2@186801|Clostridia,25VW2@186806|Eubacteriaceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Fer4_9 k141_195_19 1235798.C817_01434 2.04e-42 144.0 COG2207@1|root,COG2207@2|Bacteria,1V9Y0@1239|Firmicutes,24N56@186801|Clostridia 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 k141_195_22 1216932.CM240_0062 2.16e-148 428.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,36E14@31979|Clostridiaceae 186801|Clostridia E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k141_195_23 1121405.dsmv_2608 7.61e-08 62.8 COG0498@1|root,COG0498@2|Bacteria 2|Bacteria E threonine synthase activity - - 2.5.1.76,4.2.3.1 ko:K01733,ko:K15527 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,PALP k141_195_24 1123371.ATXH01000002_gene303 2.36e-108 383.0 COG1506@1|root,COG4625@1|root,COG1506@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis pip - 4.2.2.23 ko:K06972,ko:K18195 - - - - ko00000,ko01000,ko01002 - PL4 - Abhydrolase_1,Autotransporter,DUF285,Peptidase_S9 k141_195_26 1268240.ATFI01000018_gene22 4.03e-113 332.0 COG4422@1|root,COG4422@2|Bacteria,4NJKJ@976|Bacteroidetes,2FNM4@200643|Bacteroidia,4ANC0@815|Bacteroidaceae 976|Bacteroidetes S COG4422 Bacteriophage protein gp37 - - - - - - - - - - - - DUF5131 k141_195_27 445973.CLOBAR_02396 3.21e-48 157.0 COG2824@1|root,COG2824@2|Bacteria,1V6NA@1239|Firmicutes,24J9K@186801|Clostridia,25TK9@186804|Peptostreptococcaceae 186801|Clostridia P PhnA Zinc-Ribbon phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k141_195_28 1405.DJ92_3425 1.48e-47 175.0 COG3104@1|root,COG3104@2|Bacteria,1UHSN@1239|Firmicutes,4IS8A@91061|Bacilli,1ZS2I@1386|Bacillus 91061|Bacilli E Transmembrane secretion effector lmrP - - ko:K08152 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1,Sugar_tr k141_195_29 329726.AM1_1311 3.72e-82 265.0 2AVMD@1|root,2ZA6Y@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k141_195_31 1033810.HLPCO_000248 1.76e-66 211.0 COG0745@1|root,COG0745@2|Bacteria,2NRZI@2323|unclassified Bacteria 2|Bacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k141_195_35 1540257.JQMW01000009_gene3884 3.06e-127 370.0 COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,247ZD@186801|Clostridia,36U61@31979|Clostridiaceae 186801|Clostridia S Phenazine biosynthesis-like protein - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k141_195_36 1123009.AUID01000022_gene1388 2.36e-266 736.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - GGDEF,HATPase_c,HTH_3,PAS,PAS_3,PAS_4,PAS_9 k141_195_37 536232.CLM_2466 1.27e-29 107.0 COG5566@1|root,COG5566@2|Bacteria,1VEZS@1239|Firmicutes,24QVB@186801|Clostridia,36MRC@31979|Clostridiaceae 186801|Clostridia S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - Mor k141_195_38 1382305.AZUC01000016_gene2661 1.05e-13 67.8 COG0457@1|root,COG0457@2|Bacteria,1V3U6@1239|Firmicutes,4HFWW@91061|Bacilli,26FJY@186818|Planococcaceae 91061|Bacilli S Tetratrico peptide repeat - - - - - - - - - - - - TPR_5,TPR_6,TPR_8 k141_195_39 1218173.BALCAV_0218245 6.57e-25 94.4 COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,1ZIX5@1386|Bacillus 91061|Bacilli S Uncharacterized conserved protein (DUF2196) ywbE - - - - - - - - - - - DUF2196 k141_195_40 1195236.CTER_1484 1.95e-218 613.0 COG2865@1|root,COG2865@2|Bacteria,1TSPK@1239|Firmicutes,249QT@186801|Clostridia,3WK2A@541000|Ruminococcaceae 186801|Clostridia K Putative ATP-dependent DNA helicase recG C-terminal - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AlbA_2,HATPase_c_4 k141_195_41 509191.AEDB02000016_gene69 3.1e-28 113.0 COG1106@1|root,COG1106@2|Bacteria,1TPJN@1239|Firmicutes,249WF@186801|Clostridia,3WIMF@541000|Ruminococcaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_15,AAA_21,AAA_23 k141_195_43 1121342.AUCO01000015_gene2681 1.18e-55 194.0 COG3012@1|root,COG3012@2|Bacteria,1U6IR@1239|Firmicutes,24QIU@186801|Clostridia,36EQZ@31979|Clostridiaceae 186801|Clostridia S SEC-C motif - - - - - - - - - - - - SEC-C k141_195_45 1410613.JNKF01000010_gene353 4.88e-219 652.0 COG0286@1|root,COG0286@2|Bacteria 2|Bacteria V site-specific DNA-methyltransferase (adenine-specific) activity - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - N6_Mtase k141_195_46 585394.RHOM_02055 5.88e-147 420.0 COG0863@1|root,COG0863@2|Bacteria,1V0ZF@1239|Firmicutes,24CQV@186801|Clostridia 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k141_195_47 904293.HMPREF9176_1051 2.06e-13 71.6 COG0338@1|root,COG0338@2|Bacteria 2|Bacteria L D12 class N6 adenine-specific DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k141_199_1 1035197.HMPREF9999_00120 1.04e-25 103.0 COG1579@1|root,COG1579@2|Bacteria,4NE36@976|Bacteroidetes,2FPGP@200643|Bacteroidia,1WCYC@1283313|Alloprevotella 976|Bacteroidetes S C4-type zinc ribbon domain - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 k141_199_2 264731.PRU_0538 4.51e-09 57.4 COG1579@1|root,COG1579@2|Bacteria,4NE36@976|Bacteroidetes,2FPGP@200643|Bacteroidia 976|Bacteroidetes S Zinc ribbon domain protein - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 k141_240_2 272123.Anacy_0200 9.03e-40 138.0 2DMQT@1|root,32T2H@2|Bacteria,1G73M@1117|Cyanobacteria,1HMZ8@1161|Nostocales 1117|Cyanobacteria S PFAM T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k141_240_3 136273.GY22_14550 2.05e-15 70.1 arCOG11411@1|root,33A8Q@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k141_240_4 1200792.AKYF01000018_gene5793 2.35e-56 178.0 arCOG11412@1|root,31S84@2|Bacteria,1V6H1@1239|Firmicutes,4HJGG@91061|Bacilli,26XZS@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k141_240_5 1007103.AFHW01000139_gene1426 7.41e-61 191.0 2DB76@1|root,2Z7JZ@2|Bacteria,1V5UY@1239|Firmicutes,4HI95@91061|Bacilli,26X82@186822|Paenibacillaceae 91061|Bacilli S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k141_240_6 1007103.AFHW01000139_gene1425 1.04e-284 793.0 COG3497@1|root,COG3497@2|Bacteria,1TNY8@1239|Firmicutes,4HCQV@91061|Bacilli,26S6A@186822|Paenibacillaceae 91061|Bacilli S Phage tail sheath C-terminal domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k141_240_7 1122915.AUGY01000083_gene4483 2.39e-62 194.0 2ANY6@1|root,31DZ3@2|Bacteria,1VB43@1239|Firmicutes,4IQ37@91061|Bacilli,26XI8@186822|Paenibacillaceae 91061|Bacilli S Domain of unknown function (DUF4280) - - - - - - - - - - - - DUF4280 k141_240_10 1122917.KB899681_gene370 9.45e-60 229.0 COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1V1JU@1239|Firmicutes,4HFW5@91061|Bacilli,26UQX@186822|Paenibacillaceae 91061|Bacilli T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k141_240_13 1123288.SOV_3c05970 2.58e-36 143.0 COG2984@1|root,COG2984@2|Bacteria,1VCBZ@1239|Firmicutes 1239|Firmicutes S ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind k141_240_14 177437.HRM2_02090 3.63e-48 191.0 COG0477@1|root,COG2814@2|Bacteria,1MXKN@1224|Proteobacteria,42MP0@68525|delta/epsilon subdivisions,2WJWI@28221|Deltaproteobacteria,2MHZI@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k141_240_16 1157490.EL26_15070 1.14e-134 421.0 COG0464@1|root,COG0464@2|Bacteria,1TQXY@1239|Firmicutes,4HCJY@91061|Bacilli 91061|Bacilli O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k141_243_292 1121324.CLIT_11c02090 0.0 937.0 COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia 186801|Clostridia N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k141_243_293 864565.HMPREF0379_0477 4.66e-86 276.0 COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia,25SRR@186804|Peptostreptococcaceae 186801|Clostridia N SRP54-type protein, GTPase domain flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k141_243_294 1121324.CLIT_11c02110 2.38e-98 298.0 COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia 186801|Clostridia D Belongs to the ParA family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA k141_243_295 1286171.EAL2_c13450 3.85e-45 156.0 COG5581@1|root,COG5581@2|Bacteria 2|Bacteria M regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed pilZ - - - - - - - - - - - PilZ,YcgR_2 k141_243_296 634956.Geoth_2679 4.34e-111 335.0 COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,4HBJY@91061|Bacilli,1WEHZ@129337|Geobacillus 91061|Bacilli NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k141_243_297 1121324.CLIT_11c02140 4.31e-290 816.0 COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia 186801|Clostridia T Signal transducing histidine kinase homodimeric cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k141_243_298 1121324.CLIT_11c02150 2.72e-55 177.0 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia 186801|Clostridia NT PFAM CheW domain protein cheW2 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k141_243_299 1304284.L21TH_2260 3.37e-63 202.0 COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,36H30@31979|Clostridiaceae 186801|Clostridia NT chemotaxis protein cheC - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC k141_243_300 1121324.CLIT_11c02170 2.14e-76 231.0 COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia 186801|Clostridia NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k141_243_302 1511.CLOST_1709 1.25e-88 269.0 COG1191@1|root,COG1191@2|Bacteria,1TP9K@1239|Firmicutes,248M0@186801|Clostridia,25SNQ@186804|Peptostreptococcaceae 186801|Clostridia K Sigma-70 region 3 fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k141_243_303 1286171.EAL2_c13370 4.89e-106 330.0 COG1315@1|root,COG1315@2|Bacteria,1TR7W@1239|Firmicutes,24B18@186801|Clostridia,25VT9@186806|Eubacteriaceae 186801|Clostridia L Pfam:DUF342 - - - ko:K09749 - - - - ko00000 - - - FapA k141_243_306 1121324.CLIT_11c02210 1.57e-134 385.0 COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,25QY9@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k141_243_307 500633.CLOHIR_01275 2.9e-132 384.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,25R59@186804|Peptostreptococcaceae 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k141_243_308 1511.CLOST_1703 2.32e-115 336.0 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,25R1E@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k141_243_309 1286171.EAL2_c13330 2.97e-81 246.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,25WFH@186806|Eubacteriaceae 186801|Clostridia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k141_243_311 521097.Coch_1356 2.64e-81 250.0 COG0020@1|root,COG0020@2|Bacteria,4NF2B@976|Bacteroidetes,1HXRP@117743|Flavobacteriia,1EQBN@1016|Capnocytophaga 976|Bacteroidetes H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k141_243_312 272563.CD630_21350 6.9e-67 215.0 COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia,25QVC@186804|Peptostreptococcaceae 186801|Clostridia S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k141_243_313 1391646.AVSU01000025_gene2434 5.15e-189 535.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,25QE4@186804|Peptostreptococcaceae 186801|Clostridia I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06420 DXPR_C,DXP_redisom_C,DXP_reductoisom k141_243_314 1031288.AXAA01000001_gene2296 5.61e-79 251.0 COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,36G12@31979|Clostridiaceae 186801|Clostridia M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k141_243_315 1408823.AXUS01000027_gene1476 1.82e-153 443.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,25QSI@186804|Peptostreptococcaceae 186801|Clostridia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430 GcpE k141_243_316 1391646.AVSU01000066_gene720 0.0 1661.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,25QR9@186804|Peptostreptococcaceae 186801|Clostridia L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K02342,ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k141_243_317 1348908.KI518587_gene2989 2.75e-33 122.0 COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,4HH88@91061|Bacilli,1ZG6S@1386|Bacillus 91061|Bacilli S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k141_243_318 1121324.CLIT_11c02330 3.42e-177 503.0 COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,25QTZ@186804|Peptostreptococcaceae 186801|Clostridia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k141_243_319 1121324.CLIT_11c02340 5.38e-34 119.0 COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia 186801|Clostridia K Nucleic-acid-binding protein implicated in transcription termination ylxR - - ko:K07742 - - - - ko00000 - - - DUF448 k141_243_320 596315.HMPREF0634_1221 4.38e-25 97.8 COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,24QP3@186801|Clostridia,25RPK@186804|Peptostreptococcaceae 186801|Clostridia J Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - - - - - - - - - - Ribosomal_L7Ae k141_243_321 1286171.EAL2_c13210 0.0 906.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,25V39@186806|Eubacteriaceae 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k141_243_322 1391646.AVSU01000058_gene1025 1.08e-40 138.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,25RK5@186804|Peptostreptococcaceae 186801|Clostridia J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k141_243_323 1391646.AVSU01000058_gene1024 3.02e-99 302.0 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,25R43@186804|Peptostreptococcaceae 186801|Clostridia S DHHA1 domain protein nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k141_243_324 1121324.CLIT_11c02390 1.12e-96 294.0 COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,25QIQ@186804|Peptostreptococcaceae 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k141_243_325 1121324.CLIT_11c02400 1.85e-105 317.0 COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,25QRH@186804|Peptostreptococcaceae 186801|Clostridia H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k141_243_326 1286171.EAL2_c13160 3.43e-39 132.0 COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,25WWJ@186806|Eubacteriaceae 186801|Clostridia J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k141_243_327 1391646.AVSU01000058_gene1019 0.0 944.0 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,25QG3@186804|Peptostreptococcaceae 186801|Clostridia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k141_243_328 1476973.JMMB01000007_gene1086 5.06e-129 384.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,25QHR@186804|Peptostreptococcaceae 186801|Clostridia E ACT domain dapG - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k141_243_329 1408823.AXUS01000004_gene241 3.8e-103 314.0 COG2603@1|root,COG2603@2|Bacteria,1TQ8T@1239|Firmicutes,24AM7@186801|Clostridia,25T6W@186804|Peptostreptococcaceae 186801|Clostridia S Rhodanese Homology Domain selU - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k141_243_330 1151292.QEW_1706 5.85e-183 524.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,25QPV@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k141_243_331 864565.HMPREF0379_0015 6.72e-50 165.0 COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,25RAN@186804|Peptostreptococcaceae 186801|Clostridia I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k141_243_333 1230342.CTM_15048 1.4e-88 298.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PilJ,dCache_1,sCache_3_3 k141_243_334 445971.ANASTE_01709 9.29e-40 137.0 COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia,25XHZ@186806|Eubacteriaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - ko:K06934 - - - - ko00000 - - - DUF296 k141_243_335 1408422.JHYF01000004_gene1679 1.52e-220 611.0 COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,36E7V@31979|Clostridiaceae 186801|Clostridia E Branched-chain amino acid aminotransferase ilvE - 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k141_243_336 1121289.JHVL01000040_gene3173 4.62e-144 427.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae 186801|Clostridia V MATE efflux family protein mepA2 - - - - - - - - - - - MatE k141_243_83 1499689.CCNN01000014_gene3166 4.86e-134 387.0 COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia,36DPI@31979|Clostridiaceae 186801|Clostridia S beta-keto acid cleavage enzyme kce - 2.3.1.247 ko:K18013 ko00310,map00310 - R10564 RC02728,RC03199 ko00000,ko00001,ko01000 - - - BKACE k141_243_84 857293.CAAU_1570 9.13e-104 305.0 COG1788@1|root,COG1788@2|Bacteria,1V21Q@1239|Firmicutes,25E61@186801|Clostridia,36UK0@31979|Clostridiaceae 186801|Clostridia I TIGRFAM 3-oxoacid CoA-transferase, A subunit ctfA - 2.8.3.8,2.8.3.9 ko:K01034 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k141_243_85 1304284.L21TH_2531 1.14e-107 316.0 COG2057@1|root,COG2057@2|Bacteria,1TNY5@1239|Firmicutes,247ZM@186801|Clostridia,36GAR@31979|Clostridiaceae 186801|Clostridia I 3-oxoacid CoA-transferase, B subunit ctfB2 - 2.8.3.8,2.8.3.9 ko:K01035 ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k141_243_86 857293.CAAU_1572 1.11e-182 516.0 COG0604@1|root,COG0604@2|Bacteria,1TQ4W@1239|Firmicutes,249C7@186801|Clostridia,36ER7@31979|Clostridiaceae 186801|Clostridia C alcohol dehydrogenase kdd - 1.4.1.11 ko:K18012 ko00310,map00310 - R03349 RC00888 ko00000,ko00001,ko01000 - - - ADH_zinc_N k141_243_87 1499683.CCFF01000015_gene3348 3.2e-259 716.0 COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,36E9A@31979|Clostridiaceae 186801|Clostridia E lysine 2,3-aminomutase YodO family protein ablA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k141_243_88 1211817.CCAT010000087_gene2334 6.79e-106 320.0 2C3VR@1|root,2Z9AE@2|Bacteria,1UZNB@1239|Firmicutes,24D9F@186801|Clostridia,36FQA@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_243_89 1280692.AUJL01000033_gene504 5.29e-142 424.0 COG1193@1|root,COG1193@2|Bacteria,1TSBW@1239|Firmicutes,24814@186801|Clostridia,36FV5@31979|Clostridiaceae 186801|Clostridia L ATPase domain of DNA mismatch repair MUTS family - - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V k141_243_90 1321778.HMPREF1982_02716 1.89e-300 828.0 COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,267NE@186813|unclassified Clostridiales 186801|Clostridia F D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit kamD - 5.4.3.3 ko:K01844 ko00310,map00310 - R02852,R03275 RC00719 ko00000,ko00001,ko01000 - - - Lys-AminoMut_A k141_243_91 1211817.CCAT010000087_gene2337 4.52e-151 429.0 COG2185@1|root,COG2185@2|Bacteria,1TS6G@1239|Firmicutes,24AG8@186801|Clostridia,36UK1@31979|Clostridiaceae 186801|Clostridia I Dimerisation domain of d-ornithine 4,5-aminomutase kamE - 5.4.3.3 ko:K18011 ko00310,map00310 - R02852,R03275 RC00719 ko00000,ko00001,ko01000 - - - B12-binding,OAM_dimer k141_231_61 1211817.CCAT010000009_gene829 5.75e-140 425.0 COG0488@1|root,COG0488@2|Bacteria,1TQNA@1239|Firmicutes,248US@186801|Clostridia,36F40@31979|Clostridiaceae 186801|Clostridia S ABC transporter - - - ko:K18231 ko02010,map02010 - - - br01600,ko00000,ko00001,ko01504,ko02000 3.A.1.121.1,3.A.1.121.3 - - ABC_tran,ABC_tran_Xtn k141_231_65 1131269.AQVV01000038_gene1561 2.71e-11 73.6 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily bacE - - - - - - - - - - - MFS_1,MFS_3 k141_231_70 536232.CLM_2278 4.33e-05 50.4 COG4767@1|root,COG4767@2|Bacteria,1V3XR@1239|Firmicutes,24JP9@186801|Clostridia,36IJJ@31979|Clostridiaceae 186801|Clostridia V VanZ like family - - - - - - - - - - - - VanZ k141_231_71 1347392.CCEZ01000011_gene2454 4.73e-107 323.0 COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,36DQQ@31979|Clostridiaceae 186801|Clostridia L DNA replication protein dnaC - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 k141_231_72 1121324.CLIT_4c01850 1.91e-93 290.0 COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia,25R1R@186804|Peptostreptococcaceae 186801|Clostridia L Replication initiation and membrane attachment dnaD - - - - - - - - - - - DnaB_2 k141_231_73 1121324.CLIT_4c01840 1.91e-147 442.0 COG0739@1|root,COG0739@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia 186801|Clostridia M Peptidase, M23 - - - - - - - - - - - - G5,LysM,Peptidase_M23 k141_231_74 1511.CLOST_2557 1.85e-112 328.0 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,25R7G@186804|Peptostreptococcaceae 186801|Clostridia K Transcriptional regulatory protein, C terminal walR - - ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_231_75 1286171.EAL2_c21910 2.71e-201 583.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,25UT2@186806|Eubacteriaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein phoR2 - 2.7.13.3 ko:K07636,ko:K07652 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9 k141_231_78 1120998.AUFC01000023_gene2186 2.36e-07 58.5 COG4853@1|root,COG4853@2|Bacteria,1VF8C@1239|Firmicutes,24MBB@186801|Clostridia 186801|Clostridia S Protein conserved in bacteria - - - - - - - - - - - - YycI k141_132_1 1410653.JHVC01000032_gene1037 8.18e-44 162.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_132_2 1410653.JHVC01000032_gene1037 3.69e-82 263.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_114_1 1121335.Clst_1699 6.9e-70 227.0 COG3464@1|root,COG3464@2|Bacteria,1TQ93@1239|Firmicutes,24AMP@186801|Clostridia 186801|Clostridia L PFAM Transposase, IS204 IS1001 IS1096 IS1165 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k141_114_2 1121324.CLIT_18c00290 0.0 927.0 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,25QFM@186804|Peptostreptococcaceae 186801|Clostridia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k141_114_3 444158.MmarC6_0863 1.16e-56 188.0 arCOG03165@1|root,arCOG03165@2157|Archaea,2XXAZ@28890|Euryarchaeota,23QZB@183939|Methanococci 183939|Methanococci - - - - - - - - - - - - - - - k141_114_4 1515615.HQ41_00035 1.78e-195 556.0 COG1012@1|root,COG1012@2|Bacteria,4NEAW@976|Bacteroidetes,2FNX5@200643|Bacteroidia,22X3G@171551|Porphyromonadaceae 976|Bacteroidetes C Succinate-semialdehyde dehydrogenase sucD - 1.2.1.76 ko:K18119 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R09280 RC00004,RC00184 ko00000,ko00001,ko01000 - - - Aldedh,Fe-ADH k141_114_5 431947.PGN_0724 6.04e-168 480.0 COG1454@1|root,COG1454@2|Bacteria,4NE5Y@976|Bacteroidetes,2G351@200643|Bacteroidia,22X4K@171551|Porphyromonadaceae 976|Bacteroidetes C 4-hydroxybutyrate dehydrogenase - - 1.1.1.61 ko:K18120,ko:K19954 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R01644 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k141_114_6 1121289.JHVL01000013_gene1635 2.71e-219 615.0 COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,36FHR@31979|Clostridiaceae 186801|Clostridia C acetyl-CoA hydrolase cat - - ko:K18122 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R05336 RC00012,RC00014 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k141_114_7 742733.HMPREF9469_02204 2.72e-13 67.4 COG0694@1|root,COG0694@2|Bacteria,1TV5P@1239|Firmicutes,259JC@186801|Clostridia,221D1@1506553|Lachnoclostridium 186801|Clostridia O NifU-like domain - - - - - - - - - - - - NifU k141_114_8 1347392.CCEZ01000013_gene2567 1e-296 816.0 COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae 186801|Clostridia Q 4-hydroxyphenylacetate 3-hydroxylase C terminal abfD - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k141_114_9 1410653.JHVC01000002_gene4435 8.26e-234 654.0 COG0659@1|root,COG0659@2|Bacteria,1TT9Y@1239|Firmicutes,249RX@186801|Clostridia,36FVG@31979|Clostridiaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Xan_ur_permease k141_114_10 1410653.JHVC01000002_gene4430 5.36e-179 518.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k141_114_11 1301100.HG529419_gene3063 3.73e-209 591.0 COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,36DMU@31979|Clostridiaceae 186801|Clostridia G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k141_114_12 634956.Geoth_3751 5.68e-82 282.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1WE8N@129337|Geobacillus 91061|Bacilli T Diguanylate cyclase phosphodiesterase gmr - - - - - - - - - - - EAL,GGDEF,MASE3,PAS,PAS_8,PAS_9 k141_114_14 1511.CLOST_0493 1.41e-97 287.0 COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,25RBE@186804|Peptostreptococcaceae 186801|Clostridia C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family - - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,Rubrerythrin k141_114_15 1121324.CLIT_18c00250 6.69e-161 452.0 COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,25QMV@186804|Peptostreptococcaceae 186801|Clostridia C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k141_114_16 1286171.EAL2_c18390 4.13e-208 580.0 COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,25VGA@186806|Eubacteriaceae 186801|Clostridia C Pyruvate:ferredoxin oxidoreductase core domain II vorB - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k141_114_17 1408422.JHYF01000003_gene659 2.26e-17 75.9 COG1143@1|root,COG1143@2|Bacteria,1UHZA@1239|Firmicutes,24QVY@186801|Clostridia,36UN5@31979|Clostridiaceae 186801|Clostridia C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7 k141_114_18 272563.CD630_01140 7.34e-92 276.0 COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,25R35@186804|Peptostreptococcaceae 186801|Clostridia D bacterial-type flagellum organization - - - - - - - - - - - - CbiA k141_114_19 1476973.JMMB01000007_gene378 2.7e-182 516.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,25QTD@186804|Peptostreptococcaceae 186801|Clostridia H Belongs to the acetokinase family buk GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase k141_114_20 1408823.AXUS01000007_gene3057 1.44e-147 423.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,25RBP@186804|Peptostreptococcaceae 186801|Clostridia C phosphate butyryltransferase ptb - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB k141_114_21 1131462.DCF50_p1775 1.71e-06 58.5 COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,2612S@186807|Peptococcaceae 186801|Clostridia S PFAM YbbR-like protein - - - - - - - - - - - - YbbR k141_114_22 1511.CLOST_0484 2.44e-117 344.0 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,25R20@186804|Peptostreptococcaceae 186801|Clostridia S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N k141_114_24 398512.JQKC01000002_gene1942 5.91e-15 72.8 2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_164_1 293826.Amet_3673 1.21e-42 147.0 2AFD1@1|root,315CT@2|Bacteria,1V3KJ@1239|Firmicutes,24I0E@186801|Clostridia,36J9P@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_164_2 1410661.JNKW01000001_gene743 6.37e-141 418.0 COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia 186801|Clostridia J NOL1 NOP2 sun family rsmF - - - - - - - - - - - Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI k141_164_3 796606.BMMGA3_13460 8.6e-99 295.0 COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,4H9VU@91061|Bacilli,1ZCAM@1386|Bacillus 91061|Bacilli J Belongs to the pseudouridine synthase RsuA family rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k141_164_4 1286171.EAL2_c07350 3.28e-91 276.0 COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,25WCW@186806|Eubacteriaceae 186801|Clostridia E COG1387 Histidinol phosphatase and related hydrolases of the PHP family - - - ko:K04477 - - - - ko00000 - - - PHP k141_164_5 1121324.CLIT_10c03820 3.66e-188 538.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,25QXJ@186804|Peptostreptococcaceae 186801|Clostridia H Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k141_164_6 1499683.CCFF01000014_gene3819 7.4e-72 224.0 COG1878@1|root,COG1878@2|Bacteria,1TSXB@1239|Firmicutes,24B80@186801|Clostridia,36DH0@31979|Clostridiaceae 186801|Clostridia S PFAM cyclase family protein - - - - - - - - - - - - Cyclase k141_164_7 592027.CLG_A0016 1.78e-119 353.0 COG3240@1|root,COG3240@2|Bacteria 2|Bacteria I lipase activity - - - ko:K21831 - - - - ko00000 - - - Lipase_GDSL k141_164_8 756499.Desde_4181 6.59e-166 499.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,2642Q@186807|Peptococcaceae 186801|Clostridia NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 k141_164_9 1487921.DP68_17855 3.27e-146 429.0 COG0635@1|root,COG0635@2|Bacteria,1TUUY@1239|Firmicutes,2490N@186801|Clostridia,36GCR@31979|Clostridiaceae 186801|Clostridia H coproporphyrinogen III oxidase - - - - - - - - - - - - Radical_SAM k141_164_10 350688.Clos_2493 1.03e-106 328.0 COG1251@1|root,COG1251@2|Bacteria,1UI2I@1239|Firmicutes,25EB3@186801|Clostridia,36UJ1@31979|Clostridiaceae 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase nasD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015044,GO:0016491,GO:0016730,GO:0016731,GO:0017144,GO:0022900,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0072592,GO:0097159,GO:1901265,GO:1901363 1.6.3.4,1.7.1.15 ko:K00362,ko:K22405 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 k141_164_11 1286171.EAL2_808p06440 1.8e-79 273.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,25X4C@186806|Eubacteriaceae 186801|Clostridia NT Cache domain mcpC3 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,sCache_2 k141_164_12 592027.CLG_B2084 5.45e-79 255.0 COG5438@1|root,COG5438@2|Bacteria,1TPEV@1239|Firmicutes,249SW@186801|Clostridia,36GKC@31979|Clostridiaceae 186801|Clostridia S YibE F family protein - - - - - - - - - - - - YibE_F k141_164_13 1280692.AUJL01000016_gene1150 1.47e-183 537.0 COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,36ERD@31979|Clostridiaceae 186801|Clostridia F Belongs to the 5'-nucleotidase family - - 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 - R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Gram_pos_anchor,LysM,Metallophos k141_164_15 386415.NT01CX_1252 2.75e-156 456.0 COG1757@1|root,COG1757@2|Bacteria,1TQPI@1239|Firmicutes,2495U@186801|Clostridia,36E2J@31979|Clostridiaceae 186801|Clostridia C hmm pf03553 - - - - - - - - - - - - Na_H_antiporter k141_164_16 1499968.TCA2_2046 3.66e-27 111.0 COG0664@1|root,COG0664@2|Bacteria,1UEKS@1239|Firmicutes,4HCZE@91061|Bacilli,26SZB@186822|Paenibacillaceae 91061|Bacilli K cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k141_137_1 470145.BACCOP_01788 1.19e-90 272.0 28N3B@1|root,2ZB92@2|Bacteria,4NKKT@976|Bacteroidetes,2FQI3@200643|Bacteroidia,4AN38@815|Bacteroidaceae 976|Bacteroidetes S HmuY protein - - - - - - - - - - - - HmuY k141_186_2 1286171.EAL2_c09270 5.64e-69 211.0 COG1943@1|root,COG1943@2|Bacteria,1V1CM@1239|Firmicutes,24BK2@186801|Clostridia,25WUE@186806|Eubacteriaceae 186801|Clostridia L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k141_186_7 1121289.JHVL01000010_gene1342 3.31e-192 565.0 COG0651@1|root,COG0651@2|Bacteria,1TREH@1239|Firmicutes,248TK@186801|Clostridia,36EZ5@31979|Clostridiaceae 186801|Clostridia CP Proton-conducting membrane transporter - - - ko:K12137 - - - - ko00000,ko01000 - - - Proton_antipo_M,Proton_antipo_N k141_186_8 1121289.JHVL01000010_gene1342 3.28e-184 543.0 COG0651@1|root,COG0651@2|Bacteria,1TREH@1239|Firmicutes,248TK@186801|Clostridia,36EZ5@31979|Clostridiaceae 186801|Clostridia CP Proton-conducting membrane transporter - - - ko:K12137 - - - - ko00000,ko01000 - - - Proton_antipo_M,Proton_antipo_N k141_186_9 1121289.JHVL01000010_gene1343 2.19e-190 546.0 COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,36FKX@31979|Clostridiaceae 186801|Clostridia CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 - - - ko:K05565,ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,Proton_antipo_M,Proton_antipo_N k141_186_10 1121289.JHVL01000010_gene1344 2.64e-181 523.0 COG0651@1|root,COG0651@2|Bacteria,1TRAT@1239|Firmicutes,24AZH@186801|Clostridia,36E6V@31979|Clostridiaceae 186801|Clostridia CP Proton-conducting membrane transporter - - - ko:K05568,ko:K12141 - - - - ko00000,ko01000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k141_186_11 1286171.EAL2_808p03210 8.96e-51 163.0 COG1006@1|root,COG1006@2|Bacteria,1VBKW@1239|Firmicutes,24IY8@186801|Clostridia 186801|Clostridia P PFAM NADH-ubiquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k141_186_12 1230342.CTM_07296 5.71e-57 181.0 COG2111@1|root,COG2111@2|Bacteria,1V6XC@1239|Firmicutes,25DGN@186801|Clostridia,36UB0@31979|Clostridiaceae 186801|Clostridia P Domain related to MnhB subunit of Na+/H+ antiporter - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MnhB k141_186_13 1121324.CLIT_14c00330 2.94e-30 110.0 COG2111@1|root,COG2111@2|Bacteria,1VQK1@1239|Firmicutes,25DGP@186801|Clostridia 186801|Clostridia P Na H antiporter - - - - - - - - - - - - - k141_186_14 1121289.JHVL01000010_gene1348 2.32e-28 103.0 COG1563@1|root,COG1563@2|Bacteria,1VGXY@1239|Firmicutes,24SS2@186801|Clostridia,36MD6@31979|Clostridiaceae 186801|Clostridia P Domain of unknown function (DUF4040) - - - - - - - - - - - - DUF4040 k141_186_15 411902.CLOBOL_02361 2.85e-14 69.7 COG1320@1|root,COG1320@2|Bacteria,1U2CE@1239|Firmicutes,259WY@186801|Clostridia,222W4@1506553|Lachnoclostridium 186801|Clostridia P Na+/H+ antiporter subunit - - - - - - - - - - - - PhaG_MnhG_YufB k141_186_16 1121289.JHVL01000010_gene1350 1.26e-28 105.0 COG2212@1|root,COG2212@2|Bacteria,1VENR@1239|Firmicutes,24N3X@186801|Clostridia,36MD1@31979|Clostridiaceae 186801|Clostridia P Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k141_66_6 318464.IO99_10575 0.0 1426.0 COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,36DIP@31979|Clostridiaceae 186801|Clostridia F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k141_66_7 1499683.CCFF01000017_gene2245 1.88e-162 465.0 COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,36DTQ@31979|Clostridiaceae 186801|Clostridia F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k141_66_8 457570.Nther_0617 1.84e-74 235.0 COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Rhomboid k141_66_12 938288.HG326226_gene565 2.42e-71 219.0 COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,24HUY@186801|Clostridia 186801|Clostridia O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k141_66_14 431943.CKL_0435 3.95e-141 421.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36EGF@31979|Clostridiaceae 186801|Clostridia L DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes dbpA - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k141_66_17 545693.BMQ_0360 8.4e-310 852.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HC58@91061|Bacilli,1ZB1Y@1386|Bacillus 91061|Bacilli S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS_1 - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k141_66_18 293826.Amet_1672 1.4e-11 64.7 COG1714@1|root,COG1714@2|Bacteria,1VIRT@1239|Firmicutes,24TSH@186801|Clostridia,36N4N@31979|Clostridiaceae 186801|Clostridia S RDD family - - - - - - - - - - - - RDD k141_66_21 526222.Desal_3801 9.62e-47 175.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QAG@68525|delta/epsilon subdivisions,2X5DT@28221|Deltaproteobacteria,2MGPX@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k141_67_1 1216932.CM240_0085 1.25e-193 547.0 COG0675@1|root,COG0675@2|Bacteria,1TRNY@1239|Firmicutes,247T1@186801|Clostridia,36E4A@31979|Clostridiaceae 186801|Clostridia L Transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k141_67_2 471875.RUMLAC_00321 2.64e-38 134.0 COG2452@1|root,COG2452@2|Bacteria,1UZ1U@1239|Firmicutes,24F52@186801|Clostridia,3WNIU@541000|Ruminococcaceae 186801|Clostridia L MerR family regulatory protein - - - - - - - - - - - - MerR,MerR_1,Resolvase k141_88_3 1423321.AS29_21305 5.14e-14 74.7 COG0262@1|root,COG0262@2|Bacteria,1VAUA@1239|Firmicutes,4HH71@91061|Bacilli,1ZEDJ@1386|Bacillus 91061|Bacilli H RibD C-terminal domain ywjB - - - - - - - - - - - RibD_C k141_88_4 1353529.M899_1347 4.17e-79 291.0 COG0642@1|root,COG4251@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2MTI7@213481|Bdellovibrionales,2WIR4@28221|Deltaproteobacteria 213481|Bdellovibrionales T Histidine kinase A domain protein - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_3,Response_reg k141_88_5 1145276.T479_06240 2.16e-09 62.4 COG0697@1|root,COG0697@2|Bacteria,1V05H@1239|Firmicutes,4HFFB@91061|Bacilli 91061|Bacilli EG EamA-like transporter family - - - - - - - - - - - - EamA k141_88_6 83406.HDN1F_09910 5.25e-05 50.4 COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,1S4AM@1236|Gammaproteobacteria,1JAUM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k141_88_8 350688.Clos_0116 1.42e-57 185.0 COG3981@1|root,COG3981@2|Bacteria,1VA6C@1239|Firmicutes,24HZ2@186801|Clostridia,36INJ@31979|Clostridiaceae 186801|Clostridia S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k141_88_9 1121121.KB894298_gene4044 6.91e-71 233.0 COG2311@1|root,COG2311@2|Bacteria,1V12A@1239|Firmicutes,4HEWA@91061|Bacilli,26WXU@186822|Paenibacillaceae 91061|Bacilli S Protein of unknown function (DUF1624) - - - - - - - - - - - - DUF1624,DUF418 k141_88_10 760568.Desku_1641 5.17e-45 164.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k141_88_11 318464.IO99_15795 4.73e-55 186.0 COG0537@1|root,COG0537@2|Bacteria,1V83D@1239|Firmicutes,24PYH@186801|Clostridia,36S18@31979|Clostridiaceae 186801|Clostridia FG Domain of unknown function (DUF4269) - - - - - - - - - - - - DUF4269 k141_88_12 1121289.JHVL01000001_gene1981 2.03e-31 126.0 2EDKF@1|root,337GA@2|Bacteria,1VJWG@1239|Firmicutes,24NU6@186801|Clostridia,36MH9@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_88_14 86416.Clopa_0492 8.55e-05 51.6 2EJKN@1|root,33DBJ@2|Bacteria,1VKME@1239|Firmicutes,24HG3@186801|Clostridia,36IW9@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_88_15 500633.CLOHIR_00851 5.38e-40 146.0 COG2013@1|root,COG2013@2|Bacteria,1TP7N@1239|Firmicutes,249B4@186801|Clostridia,25SWR@186804|Peptostreptococcaceae 186801|Clostridia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k141_88_16 936573.HMPREF1147_1149 7.72e-24 95.5 2CJFJ@1|root,32S9X@2|Bacteria,1V45F@1239|Firmicutes,4H8M2@909932|Negativicutes 909932|Negativicutes S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_88_17 500633.CLOHIR_00851 9.46e-39 144.0 COG2013@1|root,COG2013@2|Bacteria,1TP7N@1239|Firmicutes,249B4@186801|Clostridia,25SWR@186804|Peptostreptococcaceae 186801|Clostridia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k141_142_1 1301100.HG529448_gene4772 1.09e-103 309.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,36E5N@31979|Clostridiaceae 186801|Clostridia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k141_142_2 545243.BAEV01000088_gene2299 3.68e-45 157.0 COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia,36ETQ@31979|Clostridiaceae 186801|Clostridia K Belongs to the sigma-70 factor family sigH - - ko:K03091 - - - - ko00000,ko03021 - - - GerE,Sigma70_r2,Sigma70_r4_2 k141_142_3 273068.TTE2312 6.61e-39 137.0 COG3688@1|root,COG3688@2|Bacteria,1V9XR@1239|Firmicutes,24MPI@186801|Clostridia,42GDZ@68295|Thermoanaerobacterales 186801|Clostridia S YacP-like NYN domain - - - ko:K06962 - - - - ko00000 - - - NYN_YacP k141_142_4 445973.CLOBAR_00073 1.91e-91 276.0 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,25QG5@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family yacO - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k141_142_5 500633.CLOHIR_01559 1.04e-128 371.0 COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,25QWX@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k141_142_6 318464.IO99_16490 2.61e-38 133.0 COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,36JIS@31979|Clostridiaceae 186801|Clostridia J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) mrnC - - ko:K11145 - - - - ko00000,ko01000,ko03009 - - - Ribonuclease_3 k141_142_7 445973.CLOBAR_00070 9.41e-226 635.0 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,25QJ0@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k141_142_8 536232.CLM_0256 1.08e-74 229.0 COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,36EH9@31979|Clostridiaceae 186801|Clostridia E Serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k141_142_9 1122128.AUEE01000004_gene478 1.99e-118 350.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,4GX3M@90964|Staphylococcaceae 91061|Bacilli E Belongs to the cysteine synthase cystathionine beta- synthase family cysK GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k141_142_10 1292035.H476_2227 5.67e-55 191.0 COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - AI-2E_transport k141_142_11 1292035.H476_0197 8.16e-272 753.0 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,25QPF@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k141_142_12 1384057.CD33_16945 2.08e-150 442.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4HB97@91061|Bacilli,3IVXB@400634|Lysinibacillus 91061|Bacilli C Belongs to the aldehyde dehydrogenase family aldH - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k141_142_14 1163745.HCD_04745 2.22e-35 150.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42QR6@68525|delta/epsilon subdivisions,2YNXQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_142_15 351627.Csac_0803 3.92e-41 163.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,42FHT@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k141_142_16 1121324.CLIT_24c00940 1.75e-280 774.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,25S74@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k141_142_17 1307761.L21SP2_3000 7.91e-49 160.0 COG0735@1|root,COG0735@2|Bacteria,2J8AC@203691|Spirochaetes 203691|Spirochaetes P Belongs to the Fur family fur - - ko:K09825 - - - - ko00000,ko03000 - - - FUR k141_142_18 545697.HMPREF0216_00705 5.57e-73 223.0 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,36HZE@31979|Clostridiaceae 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k141_142_19 1301100.HG529433_gene6512 9.92e-90 271.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,36EIP@31979|Clostridiaceae 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD k141_142_20 1294142.CINTURNW_2060 5.99e-61 195.0 COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,36IPV@31979|Clostridiaceae 186801|Clostridia I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k141_142_21 1121324.CLIT_24c01000 4.91e-149 432.0 COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,248F4@186801|Clostridia,25QEQ@186804|Peptostreptococcaceae 186801|Clostridia S PIN domain protein yacL - - - - - - - - - - - PIN,PIN_4,TRAM k141_142_22 1280692.AUJL01000034_gene404 2.14e-41 140.0 COG1694@1|root,COG1694@2|Bacteria,1VBGH@1239|Firmicutes,24JEF@186801|Clostridia,36IV1@31979|Clostridiaceae 186801|Clostridia S Mazg nucleotide pyrophosphohydrolase - - - - - - - - - - - - - k141_142_23 1121324.CLIT_24c01020 1.24e-146 425.0 COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,247J4@186801|Clostridia,25QSP@186804|Peptostreptococcaceae 186801|Clostridia L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation disA - 2.7.7.85 ko:K07067 - - - - ko00000,ko01000 - - - DisA-linker,DisA_N,HHH,HHH_2 k141_142_24 1476973.JMMB01000007_gene184 7.94e-200 568.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,25QSV@186804|Peptostreptococcaceae 186801|Clostridia O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k141_90_1 1501391.LG35_00605 5.61e-94 306.0 COG1429@1|root,COG1429@2|Bacteria,4NHR3@976|Bacteroidetes,2FP41@200643|Bacteroidia 976|Bacteroidetes H magnesium chelatase cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k141_215_2 1540257.JQMW01000013_gene1165 5.17e-88 288.0 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia,36HES@31979|Clostridiaceae 186801|Clostridia T Domain of unknown function (DUF4173) - - - - - - - - - - - - DUF4173 k141_215_3 1123009.AUID01000030_gene1359 3.57e-223 634.0 COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia,268H8@186813|unclassified Clostridiales 186801|Clostridia P Sulfate permease family sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k141_215_4 1499689.CCNN01000007_gene1058 4.13e-47 164.0 COG0600@1|root,COG0600@2|Bacteria,1V73W@1239|Firmicutes,24A2R@186801|Clostridia,36FJW@31979|Clostridiaceae 186801|Clostridia P binding-protein-dependent transport systems inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran,BPD_transp_1 k141_215_5 1280680.AUJU01000006_gene1143 5.32e-30 125.0 COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia,4BWRS@830|Butyrivibrio 186801|Clostridia P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2,Phosphonate-bd,VitK2_biosynth k141_215_6 293826.Amet_1128 1.11e-67 215.0 COG1116@1|root,COG1116@2|Bacteria,1V7QX@1239|Firmicutes,24H9Z@186801|Clostridia,36EVS@31979|Clostridiaceae 186801|Clostridia P ABC transporter ssuB1 - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k141_215_8 82654.Pse7367_1252 4.39e-10 72.4 COG0457@1|root,COG0840@1|root,COG5002@1|root,COG0457@2|Bacteria,COG0840@2|Bacteria,COG5002@2|Bacteria,1G0Y4@1117|Cyanobacteria,1HF2F@1150|Oscillatoriales 1117|Cyanobacteria NT Methyl-accepting chemotaxis protein - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - HAMP,MCPsignal,dCache_1 k141_215_9 1123511.KB905866_gene3785 1.54e-172 534.0 COG1816@1|root,COG1816@2|Bacteria,1UHMY@1239|Firmicutes 1239|Firmicutes F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - - - - - - - - - - - A_deaminase k141_215_10 768710.DesyoDRAFT_2417 1.67e-30 139.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,Pkinase k141_215_12 585501.HMPREF6123_2200 1.25e-106 319.0 COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia 186801|Clostridia M Ser Thr phosphatase family protein - - - ko:K07098 - - - - ko00000 - - - Metallophos k141_215_13 198467.NP92_03420 5.64e-20 101.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,sCache_3_3 k141_215_14 1123009.AUID01000002_gene2204 2.06e-35 142.0 COG0845@1|root,COG0845@2|Bacteria,1UUEP@1239|Firmicutes,24CTR@186801|Clostridia 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP k141_215_15 1321782.HMPREF1986_02476 1.43e-59 224.0 COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,2PSA8@265975|Oribacterium 186801|Clostridia V Efflux ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k141_215_16 679200.HMPREF9333_00710 9.02e-95 285.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,GAF_2 k141_215_17 1009370.ALO_04978 1.96e-18 86.3 COG1309@1|root,COG1309@2|Bacteria,1V695@1239|Firmicutes,4H4BF@909932|Negativicutes 909932|Negativicutes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k141_215_18 574087.Acear_0937 2.17e-71 238.0 COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia,3WB2V@53433|Halanaerobiales 186801|Clostridia T PFAM HD domain - - - - - - - - - - - - HD k141_215_19 1301100.HG529299_gene5191 3.99e-25 97.8 COG0316@1|root,COG0316@2|Bacteria,1VGGP@1239|Firmicutes,24HQ7@186801|Clostridia 186801|Clostridia S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k141_215_20 632245.CLP_2153 1.14e-105 311.0 COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,2499B@186801|Clostridia,36E74@31979|Clostridiaceae 186801|Clostridia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k141_215_21 1230342.CTM_13833 1.4e-14 86.3 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36HBC@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CZB,HAMP,MCPsignal,dCache_1 k141_215_22 350688.Clos_0093 4.07e-148 427.0 COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae 186801|Clostridia C Electron transfer flavoprotein etfA - 1.3.1.108 ko:K03522,ko:K22432 - - - - ko00000,ko01000,ko04147 - - - ETF,ETF_alpha,Fer4 k141_215_23 350688.Clos_0637 1.16e-134 387.0 COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36EI7@31979|Clostridiaceae 186801|Clostridia C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k141_215_24 350688.Clos_0091 2.05e-219 611.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,36DR1@31979|Clostridiaceae 186801|Clostridia I acyl-CoA dehydrogenase bcd2 - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k141_215_25 1304284.L21TH_1618 3.32e-139 400.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,36DG5@31979|Clostridiaceae 186801|Clostridia I Dehydrogenase hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k141_215_26 1033737.CAEV01000032_gene2157 3.29e-112 332.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae 186801|Clostridia I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k141_37_2 1033737.CAEV01000092_gene1966 1.08e-36 135.0 COG1583@1|root,COG1583@2|Bacteria,1V4U6@1239|Firmicutes,24EJT@186801|Clostridia,36JPC@31979|Clostridiaceae 186801|Clostridia L CRISPR associated protein Cas6 - - - ko:K19091 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas6 k141_37_4 1301100.HG529316_gene486 2.21e-202 604.0 COG1203@1|root,COG1203@2|Bacteria,1TQ9B@1239|Firmicutes,248UE@186801|Clostridia,36GA4@31979|Clostridiaceae 186801|Clostridia L CRISPR-associated helicase Cas3 cas3 - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD,Helicase_C,ResIII k141_37_6 1301100.HG529316_gene491 2.8e-28 105.0 COG1343@1|root,COG1343@2|Bacteria,1VAV3@1239|Firmicutes,24NM2@186801|Clostridia,36KIF@31979|Clostridiaceae 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k141_37_7 500633.CLOHIR_00655 1.08e-134 393.0 COG1518@1|root,COG1518@2|Bacteria,1TQWG@1239|Firmicutes,24889@186801|Clostridia 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1,RVT_1 k141_37_8 386415.NT01CX_0201 3.78e-62 196.0 COG1468@1|root,COG1468@2|Bacteria,1V3RV@1239|Firmicutes,25D41@186801|Clostridia,36U6R@31979|Clostridiaceae 186801|Clostridia L CRISPR-associated protein Cas4 cas4 - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k141_37_9 1150621.SMUL_1143 3.23e-53 179.0 28NN3@1|root,2ZBNI@2|Bacteria,1Q06W@1224|Proteobacteria,42RPI@68525|delta/epsilon subdivisions,2YP64@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S CRISPR-associated protein Cas5 cas5h - - ko:K19116 - - - - ko00000,ko02048 - - - - k141_128_21 929506.CbC4_2451 2.9e-80 249.0 COG1082@1|root,COG1082@2|Bacteria,1V56C@1239|Firmicutes,24D55@186801|Clostridia,36I65@31979|Clostridiaceae 186801|Clostridia L Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k141_128_22 1230342.CTM_18206 6.41e-144 423.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,36ERG@31979|Clostridiaceae 186801|Clostridia S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k141_193_14 1415774.U728_3563 2.09e-43 160.0 COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,36VTI@31979|Clostridiaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K11629 ko02020,map02020 M00469,M00738 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k141_193_15 1321778.HMPREF1982_04511 3.8e-103 304.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,2690P@186813|unclassified Clostridiales 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k141_193_16 386415.NT01CX_2428 1.95e-156 456.0 COG1114@1|root,COG1114@2|Bacteria,1TQIS@1239|Firmicutes,248I0@186801|Clostridia,36DC1@31979|Clostridiaceae 186801|Clostridia E Component of the transport system for branched-chain amino acids - - - ko:K03311 - - - - ko00000 2.A.26 - - Branch_AA_trans k141_193_17 1196322.A370_04719 6.09e-48 169.0 COG0384@1|root,COG0384@2|Bacteria,1TRAF@1239|Firmicutes,25D2F@186801|Clostridia,36DVZ@31979|Clostridiaceae 186801|Clostridia S Phenazine biosynthesis protein, PhzF family - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k141_193_18 1195246.AGRI_13975 8.21e-109 341.0 COG1874@1|root,COG1874@2|Bacteria,1R8CV@1224|Proteobacteria,1S0MI@1236|Gammaproteobacteria,469MV@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 14 - - - - - - - - - - - - Glyco_hydro_14 k141_193_20 1121289.JHVL01000056_gene2961 3.18e-44 155.0 2E6JA@1|root,3316D@2|Bacteria,1VK0E@1239|Firmicutes,24S2W@186801|Clostridia,36U3K@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_193_22 1280676.AUJO01000001_gene2240 0.000769 48.9 COG1266@1|root,COG1266@2|Bacteria,1V822@1239|Firmicutes,24CBM@186801|Clostridia,4BXIW@830|Butyrivibrio 186801|Clostridia CP CAAX protease self-immunity - - - - - - - - - - - - ABC2_membrane_3,Abi k141_193_23 1347392.CCEZ01000012_gene2556 2.81e-179 509.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,36DDS@31979|Clostridiaceae 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k141_193_24 1348635.BBJY01000001_gene2669 3.95e-24 116.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XU0F@135623|Vibrionales 135623|Vibrionales NT Cache domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_193_26 500633.CLOHIR_01485 3.07e-136 399.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,25QQR@186804|Peptostreptococcaceae 186801|Clostridia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k141_193_27 545243.BAEV01000001_gene3151 3e-139 412.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,36E1H@31979|Clostridiaceae 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k141_193_28 1235792.C808_01375 8.04e-75 242.0 COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,27IJR@186928|unclassified Lachnospiraceae 186801|Clostridia E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k141_193_29 1262449.CP6013_3396 6.41e-77 251.0 COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,36EMK@31979|Clostridiaceae 186801|Clostridia E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k141_193_30 1121324.CLIT_8c00290 3.67e-135 394.0 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,25QJT@186804|Peptostreptococcaceae 186801|Clostridia E Psort location Cytoplasmic, score aroF - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS14395 DAHP_synth_1 k141_193_33 887325.HMPREF0381_1327 1.03e-49 173.0 COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,1HUQW@1164882|Lachnoanaerobaculum 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS14365 CM_2,SKI,Shikimate_DH,Shikimate_dh_N k141_193_35 1321778.HMPREF1982_02733 9.66e-81 258.0 28HHD@1|root,2Z7T3@2|Bacteria,1TRKJ@1239|Firmicutes,24A0Y@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF3810 k141_193_37 1230342.CTM_11223 5.97e-174 494.0 COG2502@1|root,COG2502@2|Bacteria,1TP28@1239|Firmicutes,248S4@186801|Clostridia,36DK2@31979|Clostridiaceae 186801|Clostridia E aspartate--ammonia ligase asnA - 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - - AsnA k141_193_38 457421.CBFG_03094 4.58e-61 202.0 COG0583@1|root,COG0583@2|Bacteria,1TQ6Y@1239|Firmicutes,25C6V@186801|Clostridia 186801|Clostridia K lysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k141_193_39 1449126.JQKL01000006_gene800 5.11e-141 407.0 COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,267MP@186813|unclassified Clostridiales 186801|Clostridia S Thiazole biosynthesis protein ThiG - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k141_193_40 1476973.JMMB01000007_gene316 5.3e-187 530.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,25QEB@186804|Peptostreptococcaceae 186801|Clostridia C Psort location Cytoplasmic, score - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k141_193_42 990073.ATHU01000001_gene412 6.77e-121 358.0 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,42NHJ@68525|delta/epsilon subdivisions,2YNDV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k141_193_43 386415.NT01CX_0201 1.58e-52 171.0 COG1468@1|root,COG1468@2|Bacteria,1V3RV@1239|Firmicutes,25D41@186801|Clostridia,36U6R@31979|Clostridiaceae 186801|Clostridia L CRISPR-associated protein Cas4 cas4 - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k141_193_44 632245.CLP_0453 8.94e-30 108.0 COG1343@1|root,COG1343@2|Bacteria,1VAV3@1239|Firmicutes,24NM2@186801|Clostridia,36KIF@31979|Clostridiaceae 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k141_193_45 696281.Desru_3127 4.63e-24 102.0 COG2963@1|root,COG2963@2|Bacteria,1V4FD@1239|Firmicutes,24GUY@186801|Clostridia,264CX@186807|Peptococcaceae 186801|Clostridia L Winged helix-turn helix - - - - - - - - - - - - HTH_28,HTH_Tnp_1 k141_193_49 744980.TRICHSKD4_1192 3.79e-32 125.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,2TW57@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07090 - - - - ko00000 - - - TauE k141_193_51 1410653.JHVC01000002_gene4183 1.29e-12 79.0 COG0840@1|root,COG3221@1|root,COG0840@2|Bacteria,COG3221@2|Bacteria,1TR1Z@1239|Firmicutes,249QC@186801|Clostridia,36EW3@31979|Clostridiaceae 186801|Clostridia NPT chemotaxis protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - MCPsignal,Phosphonate-bd k141_193_52 1294265.JCM21738_1801 1.94e-209 593.0 COG3314@1|root,COG3314@2|Bacteria,1TR35@1239|Firmicutes,4HAB6@91061|Bacilli,1ZARZ@1386|Bacillus 91061|Bacilli S protein conserved in bacteria - - - - - - - - - - - - Gate k141_193_53 1304284.L21TH_2733 1.74e-08 61.2 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EVU@31979|Clostridiaceae 186801|Clostridia NT histidine kinase HAMP region domain protein mcpC3 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,sCache_2 k141_193_54 1444309.JAQG01000139_gene1543 2.78e-131 394.0 COG1473@1|root,COG1473@2|Bacteria,1TPEJ@1239|Firmicutes,4HA9M@91061|Bacilli,26SZI@186822|Paenibacillaceae 91061|Bacilli S Peptidase dimerisation domain - - - ko:K12940 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k141_193_56 1293054.HSACCH_02488 5.22e-205 583.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3WA9C@53433|Halanaerobiales 186801|Clostridia C PFAM Na H antiporter - - - - - - - - - - - - Na_H_antiporter k141_193_57 1196322.A370_04794 4.09e-76 234.0 COG0500@1|root,COG0500@2|Bacteria,1UHQ8@1239|Firmicutes,25EKK@186801|Clostridia,36USP@31979|Clostridiaceae 186801|Clostridia Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_12,Methyltransf_23 k141_193_59 1123009.AUID01000001_gene1132 2.18e-41 141.0 COG1846@1|root,COG1846@2|Bacteria,1TTM4@1239|Firmicutes,25MWT@186801|Clostridia,26C6C@186813|unclassified Clostridiales 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k141_193_61 696281.Desru_0943 6.4e-07 50.4 COG0745@1|root,COG0745@2|Bacteria,1TR8K@1239|Firmicutes,24DTS@186801|Clostridia,261ZH@186807|Peptococcaceae 186801|Clostridia T response regulator receiver cssR - - ko:K07770 ko02020,map02020 M00448 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_193_62 1423321.AS29_16540 4.32e-39 144.0 COG0745@1|root,COG0745@2|Bacteria,1TR8K@1239|Firmicutes,4HBSB@91061|Bacilli,1ZBX5@1386|Bacillus 91061|Bacilli T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cssR - - ko:K07770 ko02020,map02020 M00448 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_193_66 1321778.HMPREF1982_03391 2.19e-44 160.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1TTAX@1239|Firmicutes,24BT9@186801|Clostridia 186801|Clostridia K transcription activator, effector binding - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18,HTH_AraC k141_193_67 702450.CUW_2797 5.26e-48 163.0 COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,3VS9J@526524|Erysipelotrichia 526524|Erysipelotrichia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k141_193_71 886882.PPSC2_c1551 4.87e-69 219.0 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,4HFKP@91061|Bacilli,26R4A@186822|Paenibacillaceae 91061|Bacilli T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain yycF - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k141_193_72 290402.Cbei_3358 2.5e-29 128.0 COG0642@1|root,COG2205@2|Bacteria,1TRD2@1239|Firmicutes,247M3@186801|Clostridia,36EWQ@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_193_73 1286171.EAL2_808p06960 1.14e-179 513.0 COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,25UR9@186806|Eubacteriaceae 186801|Clostridia C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltT - - - - - - - - - - - SDF k141_193_74 37659.JNLN01000001_gene499 8.24e-57 191.0 COG4753@1|root,COG4753@2|Bacteria,1TPFP@1239|Firmicutes,24AIA@186801|Clostridia,36G5B@31979|Clostridiaceae 186801|Clostridia T YcbB domain - - - ko:K07719 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,YcbB k141_193_75 273068.TTE1202 1.05e-44 169.0 COG3290@1|root,COG3290@2|Bacteria,1TQNZ@1239|Firmicutes,249FI@186801|Clostridia 186801|Clostridia T Histidine kinase-like ATPases - - 2.7.13.3 ko:K07717 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k141_193_76 1463858.JOHR01000006_gene373 1.15e-27 117.0 COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria 201174|Actinobacteria Q beta-lactamase domain protein - - - ko:K05555 ko01057,ko01130,map01057,map01130 M00778 R09305 - ko00000,ko00001,ko00002,ko01000,ko01008 - - - Lactamase_B k141_193_77 86416.Clopa_4590 0.000122 53.9 COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36F2H@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_193_78 220664.PFL_4082 9.31e-63 214.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1YMKR@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0071944 - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k141_193_79 1499684.CCNP01000021_gene2876 5.47e-66 222.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,24AWU@186801|Clostridia,36FYR@31979|Clostridiaceae 186801|Clostridia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k141_240_117 1121324.CLIT_4c00110 5.97e-90 276.0 COG0697@1|root,COG0697@2|Bacteria,1TR1G@1239|Firmicutes,24DN8@186801|Clostridia 186801|Clostridia EG PFAM EamA-like transporter family - - - - - - - - - - - - EamA k141_240_118 293826.Amet_0368 4.48e-110 339.0 COG4591@1|root,COG4591@2|Bacteria,1VBN5@1239|Firmicutes,25EBV@186801|Clostridia,36UJS@31979|Clostridiaceae 186801|Clostridia M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k141_240_119 293826.Amet_0367 8.16e-121 382.0 COG1361@1|root,COG1361@2|Bacteria,1TQHN@1239|Firmicutes,24BUH@186801|Clostridia,36ICF@31979|Clostridiaceae 186801|Clostridia M COG NOG29868 non supervised orthologous group - - - - - - - - - - - - CARDB k141_240_120 1232449.BAHV02000011_gene2166 6.08e-90 275.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,26A5Y@186813|unclassified Clostridiales 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_240_122 1121324.CLIT_24c01070 0.0 960.0 COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,25QW4@186804|Peptostreptococcaceae 186801|Clostridia J Elongation factor fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k141_240_124 632292.Calhy_0640 4.42e-86 265.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,42F7U@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k141_240_125 941824.TCEL_01741 1.86e-146 449.0 COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,36DF8@31979|Clostridiaceae 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k141_240_127 1304284.L21TH_1742 4.31e-74 247.0 COG0642@1|root,COG2205@2|Bacteria,1UYC9@1239|Firmicutes,24CPQ@186801|Clostridia,36GIS@31979|Clostridiaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_240_128 97139.C824_05297 1.07e-51 175.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,36EQW@31979|Clostridiaceae 186801|Clostridia KT response regulator srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C k141_240_129 1408422.JHYF01000020_gene1828 0.0 1119.0 COG0209@1|root,COG0209@2|Bacteria,1TT3U@1239|Firmicutes,24C4U@186801|Clostridia,36G9Z@31979|Clostridiaceae 186801|Clostridia F TIGRFAM ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC k141_241_1 1345695.CLSA_c03410 3.3e-15 79.7 COG3863@1|root,COG3863@2|Bacteria,1VESN@1239|Firmicutes,24E63@186801|Clostridia,36HGS@31979|Clostridiaceae 186801|Clostridia M PFAM Orthopoxvirus protein of - - - - - - - - - - - - Peptidase_C92 k141_241_3 941824.TCEL_01370 5.55e-266 737.0 COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TP5X@1239|Firmicutes,247WT@186801|Clostridia,36DI9@31979|Clostridiaceae 186801|Clostridia G Pts system treP - 2.7.1.201 ko:K02818,ko:K02819 ko00500,ko02060,map00500,map02060 M00270 R02780 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.13,4.A.1.2.4,4.A.1.2.8 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k141_241_4 926692.AZYG01000086_gene731 3.16e-297 823.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,3WAEN@53433|Halanaerobiales 186801|Clostridia G PFAM Alpha amylase, catalytic domain treC - 3.2.1.1,3.2.1.93 ko:K01176,ko:K01226 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R00837,R02108,R02112,R06113,R11262 RC00049 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k141_241_5 1304284.L21TH_0752 1.38e-94 284.0 COG2188@1|root,COG2188@2|Bacteria,1TRF6@1239|Firmicutes,249CC@186801|Clostridia,36EWV@31979|Clostridiaceae 186801|Clostridia K trehalose operon repressor treR - - ko:K03486 - - - - ko00000,ko03000 - - - GntR,UTRA k141_241_6 66692.ABC3543 1.51e-06 52.8 2A6G4@1|root,30V95@2|Bacteria,1UCGY@1239|Firmicutes,4INZB@91061|Bacilli,1ZP5K@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k141_241_7 1121289.JHVL01000001_gene1959 1.87e-307 859.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,36DF0@31979|Clostridiaceae 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k141_241_8 272623.L192240 6.9e-21 87.0 COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,4HPFS@91061|Bacilli,1YBWC@1357|Lactococcus 91061|Bacilli P FeoA feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k141_241_9 1230342.CTM_13758 1.4e-13 66.2 COG1918@1|root,COG1918@2|Bacteria,1TV62@1239|Firmicutes,24X6Y@186801|Clostridia 186801|Clostridia P FeoA - - - - - - - - - - - - FeoA k141_241_10 1121289.JHVL01000001_gene1957 1.21e-30 110.0 2DMMF@1|root,32SEK@2|Bacteria,1VAB3@1239|Firmicutes,24N8S@186801|Clostridia,36MIU@31979|Clostridiaceae 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2325) - - - - - - - - - - - - DUF2325 k141_241_11 1280694.AUJQ01000006_gene900 5.89e-71 226.0 COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,3NGD0@46205|Pseudobutyrivibrio 186801|Clostridia S TIGR00268 family - - - ko:K06864 - - - - ko00000 - - - ATP_bind_3,NAD_synthase,QueC k141_241_12 1128398.Curi_c24320 1.43e-86 259.0 COG0288@1|root,COG0288@2|Bacteria,1V1EC@1239|Firmicutes,2495A@186801|Clostridia,26B2F@186813|unclassified Clostridiales 186801|Clostridia P Reversible hydration of carbon dioxide cah - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k141_241_13 1528106.JRJE01000002_gene1985 1.16e-68 238.0 COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1QVHK@1224|Proteobacteria 1224|Proteobacteria T PAS fold - - - - - - - - - - - - GGDEF,PAS_3,PAS_9 k141_241_14 1211817.CCAT010000043_gene3494 3e-173 488.0 COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,247J8@186801|Clostridia,36F77@31979|Clostridiaceae 186801|Clostridia Q Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway psuG - 4.2.1.70 ko:K16329 ko00240,map00240 - R01055 RC00432,RC00433 ko00000,ko00001,ko01000 - - - Indigoidine_A k141_241_15 332101.JIBU02000043_gene1520 1.96e-160 461.0 COG0524@1|root,COG1846@1|root,COG0524@2|Bacteria,COG1846@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,36F1Z@31979|Clostridiaceae 186801|Clostridia G hmm pf00294 rbsK - 2.7.1.15,2.7.1.83 ko:K00852,ko:K16328 ko00030,ko00240,map00030,map00240 - R01051,R02750,R03315 RC00002,RC00017 ko00000,ko00001,ko01000 - - - HTH_24,PfkB k141_241_16 1454004.AW11_00120 1.7e-31 137.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2WGRD@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_8,Protoglobin k141_241_17 1169144.KB910946_gene3652 5.25e-05 53.1 COG3290@1|root,COG3829@1|root,COG3290@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,1ZAZA@1386|Bacillus 91061|Bacilli KT Transcriptional regulator bkdR - - - - - - - - - - - DapB_N,HTH_8,PAS,Sigma54_activat k141_241_18 926561.KB900618_gene379 7.01e-55 186.0 COG3711@1|root,COG3711@2|Bacteria,1TQJJ@1239|Firmicutes,249XA@186801|Clostridia,3WB1N@53433|Halanaerobiales 186801|Clostridia K PFAM CAT RNA binding domain - - - ko:K03480 - - - - ko00000,ko03000 - - - CAT_RBD,PRD k141_241_19 865861.AZSU01000003_gene1953 6.45e-192 548.0 COG1263@1|root,COG1263@2|Bacteria,1TPJ8@1239|Firmicutes,24809@186801|Clostridia,36DWW@31979|Clostridiaceae 186801|Clostridia G Pts system nagE - 2.7.1.193 ko:K02803,ko:K02804 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 - - PTS_EIIB,PTS_EIIC k141_241_20 1304284.L21TH_1862 7.79e-146 425.0 COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,36FD4@31979|Clostridiaceae 186801|Clostridia G Belongs to the metallo-dependent hydrolases superfamily. NagA family nagA - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k141_241_21 1304284.L21TH_1863 4.16e-118 344.0 COG0363@1|root,COG0363@2|Bacteria,1TP10@1239|Firmicutes,248HK@186801|Clostridia,36E4F@31979|Clostridiaceae 186801|Clostridia G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso k141_241_22 926692.AZYG01000059_gene163 3.68e-51 180.0 COG1263@1|root,COG2190@1|root,COG1263@2|Bacteria,COG2190@2|Bacteria,1TPJ8@1239|Firmicutes,24809@186801|Clostridia,3WBJZ@53433|Halanaerobiales 1239|Firmicutes G phosphotransferase system, EIIB - - 2.7.1.199 ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00809 R02738 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.9 - - PTS_EIIA_1,PTS_EIIB,PTS_EIIC k141_39_115 696281.Desru_3472 3.4e-08 65.5 COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261XC@186807|Peptococcaceae 186801|Clostridia NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k141_39_116 1444309.JAQG01000140_gene1347 9.1e-19 99.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein tlpA1 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CHASE3,HAMP,MCPsignal k141_39_117 511.JT27_15580 1.28e-66 223.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,3T52S@506|Alcaligenaceae 28216|Betaproteobacteria C 4Fe-4S single cluster domain nirJ - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k141_39_118 1121289.JHVL01000036_gene2566 3.25e-144 417.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36E8H@31979|Clostridiaceae 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k141_39_119 913865.DOT_3444 6.23e-23 100.0 COG1522@1|root,COG1522@2|Bacteria,1V6TH@1239|Firmicutes,24JH9@186801|Clostridia,260KT@186807|Peptococcaceae 186801|Clostridia K transcriptional regulator, AsnC family - - - - - - - - - - - - HTH_AsnC-type k141_39_121 1196322.A370_03721 5.17e-67 213.0 COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia,36HZR@31979|Clostridiaceae 186801|Clostridia M PFAM LrgB family protein lrgB - - - - - - - - - - - LrgB k141_39_122 999411.HMPREF1092_00646 1.48e-18 82.0 COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,24MMB@186801|Clostridia,36KP1@31979|Clostridiaceae 186801|Clostridia S LrgA family lrgA - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA k141_236_1 927658.AJUM01000034_gene410 1.23e-87 259.0 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,2FPSJ@200643|Bacteroidia,3XJYT@558415|Marinilabiliaceae 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k141_238_1 189425.PGRAT_24935 2.59e-59 198.0 COG0675@1|root,COG0675@2|Bacteria,1TT4J@1239|Firmicutes,4HEKB@91061|Bacilli,26UMB@186822|Paenibacillaceae 91061|Bacilli L Putative transposase DNA-binding domain - - - - - - - - - - - - OrfB_IS605,OrfB_Zn_ribbon k141_238_3 1158606.I579_01468 6.55e-29 118.0 COG3464@1|root,COG3464@2|Bacteria,1TQ93@1239|Firmicutes,4HC0Q@91061|Bacilli,4B0ZT@81852|Enterococcaceae 91061|Bacilli L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k141_44_1 1345695.CLSA_c08180 5.68e-43 164.0 COG3501@1|root,COG5263@1|root,COG3501@2|Bacteria,COG5263@2|Bacteria,1UY4Z@1239|Firmicutes 1239|Firmicutes M Putative cell wall binding repeat cbpE - - - - - - - - - - - CW_binding_1,Lactamase_B,Peptidase_C39_2 k141_239_2 269798.CHU_2580 6.99e-13 73.6 COG4330@1|root,COG4330@2|Bacteria,4NNT4@976|Bacteroidetes,47PCZ@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1361) - - - - - - - - - - - - DUF1361 k141_239_6 3218.PP1S52_142V6.1 2.65e-05 50.8 COG0456@1|root,KOG3138@2759|Eukaryota,37IRZ@33090|Viridiplantae,3GDKY@35493|Streptophyta 35493|Streptophyta S N-alpha-acetyltransferase - GO:0000070,GO:0000278,GO:0000280,GO:0000819,GO:0003674,GO:0003824,GO:0004402,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0006464,GO:0006473,GO:0006474,GO:0006475,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0007064,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0010485,GO:0016043,GO:0016407,GO:0016410,GO:0016569,GO:0016570,GO:0016573,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022402,GO:0031365,GO:0034085,GO:0034087,GO:0034212,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043543,GO:0043967,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048285,GO:0051276,GO:0051604,GO:0052858,GO:0061733,GO:0070601,GO:0071704,GO:0071840,GO:0071962,GO:0098813,GO:0140014,GO:1901564,GO:1903047 2.3.1.258 ko:K20793 - - - - ko00000,ko01000,ko03036 - - - Acetyltransf_1 k141_239_7 1120998.AUFC01000015_gene1589 3.31e-48 165.0 COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,24HZH@186801|Clostridia 186801|Clostridia S Serine aminopeptidase, S33 - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Hydrolase_4 k141_239_8 431943.CKL_2492 5.89e-31 118.0 COG1309@1|root,COG1309@2|Bacteria,1U9UE@1239|Firmicutes,24F64@186801|Clostridia,36W0I@31979|Clostridiaceae 186801|Clostridia K WHG domain - - - - - - - - - - - - TetR_N,WHG k141_122_1 411462.DORLON_01199 4.71e-36 139.0 COG0697@1|root,COG0697@2|Bacteria,1V2EI@1239|Firmicutes,24GU6@186801|Clostridia,27WQE@189330|Dorea 186801|Clostridia EG COG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k141_122_2 1123288.SOV_3c02280 1.73e-76 250.0 COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,4H3DJ@909932|Negativicutes 909932|Negativicutes S Psort location Cytoplasmic, score - - - ko:K18475 - - - - ko00000,ko01000,ko02035 - - - - k141_122_3 929506.CbC4_0444 2.04e-183 564.0 COG3291@1|root,COG3291@2|Bacteria,1TSRU@1239|Firmicutes,24BRF@186801|Clostridia,36HRJ@31979|Clostridiaceae 186801|Clostridia S hmm pf04151 colG - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - PKD,PPC,Peptidase_M9,Peptidase_M9_N k141_122_4 195103.CPF_0166 1.45e-187 580.0 COG3291@1|root,COG3291@2|Bacteria,1TSRU@1239|Firmicutes,24BRF@186801|Clostridia,36HRJ@31979|Clostridiaceae 186801|Clostridia S hmm pf04151 colG - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - PKD,PPC,Peptidase_M9,Peptidase_M9_N k141_122_6 1121324.CLIT_2c02870 1.08e-213 599.0 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,25R1Z@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k141_122_7 1117318.PRUB_08387 5.55e-71 250.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q1JG@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_9,dCache_1 k141_122_8 1175629.AJTG01000031_gene1547 1.14e-06 52.8 COG3238@1|root,COG3238@2|Bacteria,1V0FB@1239|Firmicutes,4HFG7@91061|Bacilli 91061|Bacilli S Putative inner membrane exporter, YdcZ - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ k141_122_9 290402.Cbei_1744 4.27e-24 98.2 COG3238@1|root,COG3238@2|Bacteria,1V7PX@1239|Firmicutes,24MM7@186801|Clostridia,36KFC@31979|Clostridiaceae 186801|Clostridia S Putative inner membrane exporter, YdcZ - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ k141_122_10 697303.Thewi_1506 4.66e-20 102.0 COG0103@1|root,COG5279@1|root,COG0103@2|Bacteria,COG5279@2|Bacteria,1V8TE@1239|Firmicutes,24CI3@186801|Clostridia,42GHD@68295|Thermoanaerobacterales 186801|Clostridia D transglutaminase domain protein - - - - - - - - - - - - Big_5,CW_binding_2,Cu_amine_oxidN1,Transglut_core k141_122_11 742723.HMPREF9477_00971 8.92e-86 269.0 COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,24DP8@186801|Clostridia,27PF2@186928|unclassified Lachnospiraceae 186801|Clostridia E Ornithine cyclodeaminase/mu-crystallin family ocd - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k141_122_12 1128398.Curi_c26090 2.02e-100 298.0 COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,267ZD@186813|unclassified Clostridiales 186801|Clostridia T Transcriptional regulatory protein, C terminal arlR - - - - - - - - - - - Response_reg,Trans_reg_C k141_122_13 635013.TherJR_2683 7.6e-97 308.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1UHQC@1239|Firmicutes,25EVD@186801|Clostridia,267E4@186807|Peptococcaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_122_14 386456.JQKN01000002_gene2429 4.67e-06 53.5 COG1309@1|root,arCOG02648@2157|Archaea 2157|Archaea K COG1309 Transcriptional regulator - - - - - - - - - - - - TetR_N k141_26_2 1410653.JHVC01000032_gene1037 1.31e-84 270.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_26_3 1410653.JHVC01000032_gene1037 9.41e-84 268.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_26_4 1410653.JHVC01000032_gene1037 1.38e-89 283.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_26_5 1121342.AUCO01000009_gene415 4.47e-56 179.0 COG1342@1|root,COG1342@2|Bacteria,1V5RE@1239|Firmicutes,25CFP@186801|Clostridia,36I1U@31979|Clostridiaceae 186801|Clostridia S Belongs to the UPF0251 family - - - - - - - - - - - - DUF134 k141_26_6 572480.Arnit_2447 1.7e-14 73.9 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2YPGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the Fur family fur GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03711 - - - - ko00000,ko03000 - - - FUR k141_26_7 1121289.JHVL01000017_gene775 5.2e-42 141.0 COG1433@1|root,COG1433@2|Bacteria,1TRMQ@1239|Firmicutes,24BUF@186801|Clostridia,36JK4@31979|Clostridiaceae 186801|Clostridia S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co k141_26_8 1121324.CLIT_5c01190 8.05e-77 242.0 COG1149@1|root,COG1149@2|Bacteria,1TQI9@1239|Firmicutes,2484J@186801|Clostridia 186801|Clostridia C CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - CbiA,Fer4 k141_240_17 553973.CLOHYLEM_06213 1.84e-21 94.0 2E7AK@1|root,32CDW@2|Bacteria,1TYNM@1239|Firmicutes,2586X@186801|Clostridia,22349@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF4255) - - - - - - - - - - - - DUF4255 k141_240_20 555079.Toce_0183 1.08e-27 105.0 COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,25B8J@186801|Clostridia,42JEC@68295|Thermoanaerobacterales 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k141_240_21 1582152.A0A0A8WJI9_9CAUD 4.06e-44 151.0 4QCT7@10239|Viruses,4QPFU@28883|Caudovirales,4QIIN@10662|Myoviridae 10662|Myoviridae S 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k141_240_22 1292035.H476_3395 0.0 1197.0 COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,25QKN@186804|Peptostreptococcaceae 186801|Clostridia F Anaerobic ribonucleoside-triphosphate reductase nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD k141_240_23 1391646.AVSU01000047_gene1583 2.87e-206 588.0 COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,248XW@186801|Clostridia,25QXP@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15780 AAA_26,CbiA,GATase_3 k141_240_24 1408823.AXUS01000033_gene2826 9.72e-150 436.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25QZN@186804|Peptostreptococcaceae 186801|Clostridia E Aminotransferase aspC - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k141_240_26 1511.CLOST_0952 2.95e-283 783.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,25QCN@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind k141_240_27 1391646.AVSU01000035_gene2112 1.27e-70 217.0 COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,25RD0@186804|Peptostreptococcaceae 186801|Clostridia K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k141_240_28 1151292.QEW_4184 1.29e-124 367.0 COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,25QSU@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k141_240_29 1286171.EAL2_c17920 1.38e-135 389.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,25VB2@186806|Eubacteriaceae 186801|Clostridia H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k141_240_30 999411.HMPREF1092_01928 7.39e-46 157.0 COG4684@1|root,COG4684@2|Bacteria,1V2M1@1239|Firmicutes,249YQ@186801|Clostridia,36DT8@31979|Clostridiaceae 186801|Clostridia S ECF transporter, substrate-specific component - - - - - - - - - - - - ECF_trnsprt k141_240_31 634498.mru_1708 6.48e-34 132.0 COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,23PCT@183925|Methanobacteria 183925|Methanobacteria E Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k141_240_32 1452536.JARE01000042_gene86 3.65e-06 56.6 COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4FR9G@85023|Microbacteriaceae 201174|Actinobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k141_240_33 1042156.CXIVA_06140 3.18e-141 424.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,36EUU@31979|Clostridiaceae 186801|Clostridia E family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k141_240_34 1511.CLOST_0947 3.07e-123 363.0 COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,24AVR@186801|Clostridia,25R4E@186804|Peptostreptococcaceae 186801|Clostridia EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 k141_240_35 997296.PB1_13899 1.01e-69 227.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,1ZBI9@1386|Bacillus 91061|Bacilli K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k141_240_36 1511.CLOST_0945 4.54e-203 572.0 COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia 186801|Clostridia C decarboxylase beta subunit gcdB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k141_240_37 1501391.LG35_01735 2.85e-10 62.0 COG4770@1|root,COG4770@2|Bacteria,4NSWV@976|Bacteroidetes,2FRYI@200643|Bacteroidia,22UGJ@171550|Rikenellaceae 976|Bacteroidetes I Biotin-requiring enzyme mmdC - - - - - - - - - - - Biotin_lipoyl k141_240_38 1511.CLOST_0943 1.02e-19 85.9 COG3630@1|root,COG3630@2|Bacteria,1VKW0@1239|Firmicutes,24VA0@186801|Clostridia 186801|Clostridia C decarboxylase, gamma subunit - - - - - - - - - - - - OAD_gamma k141_240_39 1408422.JHYF01000006_gene1278 1.12e-294 813.0 COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,36E1X@31979|Clostridiaceae 186801|Clostridia I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) yqjD - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k141_240_40 1476973.JMMB01000007_gene1301 2.2e-75 229.0 COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,24HPI@186801|Clostridia,25T50@186804|Peptostreptococcaceae 186801|Clostridia E Glyoxalase-like domain mce - 4.4.1.5,5.1.99.1 ko:K01759,ko:K05606 ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02530,R02765,R09979 RC00004,RC00740,RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k141_240_41 1391646.AVSU01000043_gene1438 2.66e-146 421.0 COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,25SGB@186804|Peptostreptococcaceae 186801|Clostridia E ArgK protein argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k141_240_42 1408422.JHYF01000006_gene1275 2.16e-79 237.0 COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,36J94@31979|Clostridiaceae 186801|Clostridia I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding k141_240_43 1511.CLOST_0938 3.04e-312 861.0 COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia 186801|Clostridia I PFAM Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k141_240_45 1476973.JMMB01000007_gene1297 3.98e-280 775.0 COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,25SH7@186804|Peptostreptococcaceae 186801|Clostridia C Acetyl-CoA hydrolase/transferase N-terminal domain - - 2.8.3.18 ko:K18118 ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R10343 RC00012,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k141_240_46 1121289.JHVL01000048_gene893 3.72e-32 115.0 2CKNI@1|root,32SCP@2|Bacteria,1VCRC@1239|Firmicutes,24QX2@186801|Clostridia,36NU6@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF3870) - - - - - - - - - - - - DUF3870 k141_240_47 1121289.JHVL01000048_gene892 3.58e-206 584.0 COG2985@1|root,COG2985@2|Bacteria,1TT3J@1239|Firmicutes,24AC4@186801|Clostridia,36F5N@31979|Clostridiaceae 186801|Clostridia S Predicted Permease Membrane Region - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex k141_240_48 1121324.CLIT_13c02400 0.0 886.0 COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,25QQY@186804|Peptostreptococcaceae 186801|Clostridia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k141_240_49 1511.CLOST_0936 6.68e-152 447.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,25QZ7@186804|Peptostreptococcaceae 186801|Clostridia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k141_240_52 545243.BAEV01000032_gene498 1.91e-103 315.0 COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,36DR8@31979|Clostridiaceae 186801|Clostridia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k141_240_53 1121324.CLIT_13c02350 3.07e-93 280.0 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,25QQ7@186804|Peptostreptococcaceae 186801|Clostridia K FCD ydfH_4 - - - - - - - - - - - FCD,GntR k141_240_54 1151292.QEW_4200 6.61e-93 284.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,25QT8@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k141_240_55 1286171.EAL2_c18020 2.3e-38 130.0 COG4466@1|root,COG4466@2|Bacteria,1VEQM@1239|Firmicutes,24QN2@186801|Clostridia,25XU3@186806|Eubacteriaceae 186801|Clostridia S Biofilm formation stimulator VEG veg - - - - - - - - - - - VEG k141_240_56 1511.CLOST_0929 4.6e-87 267.0 COG1378@1|root,COG1378@2|Bacteria,1TSB2@1239|Firmicutes,25CS5@186801|Clostridia 186801|Clostridia K Archaeal transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB k141_240_57 1511.CLOST_0928 4.89e-164 465.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,25QD2@186804|Peptostreptococcaceae 186801|Clostridia E Amino acid kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k141_240_58 1511.CLOST_0927 2.86e-195 546.0 COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,25SFG@186804|Peptostreptococcaceae 186801|Clostridia E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12430 OTCace,OTCace_N k141_240_59 1511.CLOST_0926 1.43e-214 602.0 COG2235@1|root,COG2235@2|Bacteria,1TQWS@1239|Firmicutes,249V9@186801|Clostridia,25SER@186804|Peptostreptococcaceae 186801|Clostridia E Amidinotransferase arcA - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf k141_240_60 1286171.EAL2_c18040 6.69e-69 218.0 293PP@1|root,2ZR5C@2|Bacteria,1VBW4@1239|Firmicutes,24NKJ@186801|Clostridia 186801|Clostridia S UPF0489 domain - - - - - - - - - - - - UPF0489 k141_240_61 1286171.EAL2_c02670 2.13e-114 350.0 COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,25XB2@186806|Eubacteriaceae 186801|Clostridia KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - MASE3,PAS_4,PAS_9,SpoIIE k141_240_62 391009.Tmel_1183 1.33e-13 68.9 COG1366@1|root,COG1366@2|Bacteria,2GDAN@200918|Thermotogae 200918|Thermotogae T PFAM Sulfate transporter antisigma-factor antagonist STAS - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS k141_240_64 584708.Apau_0873 1.61e-65 236.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,3T9SQ@508458|Synergistetes 508458|Synergistetes T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k141_240_66 1121935.AQXX01000126_gene953 5.7e-30 134.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XR55@135619|Oceanospirillales 135619|Oceanospirillales NT Cache domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,dCache_1 k141_240_67 500633.CLOHIR_02212 2.05e-94 282.0 COG0564@1|root,COG0564@2|Bacteria,1TX59@1239|Firmicutes,24HTV@186801|Clostridia,25QEF@186804|Peptostreptococcaceae 186801|Clostridia J Pseudouridine synthase rluC - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k141_240_68 1121324.CLIT_13c02280 1.69e-180 505.0 COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia,25QYD@186804|Peptostreptococcaceae 186801|Clostridia J S-adenosylmethionine-dependent methyltransferase rlmL_1 - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k141_240_69 1121324.CLIT_13c02260 2.15e-71 219.0 COG1528@1|root,COG1528@2|Bacteria,1V1BJ@1239|Firmicutes,24FUF@186801|Clostridia,25RG7@186804|Peptostreptococcaceae 186801|Clostridia P Iron-storage protein ftnA - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k141_39_62 1294142.CINTURNW_4086 4.21e-59 230.0 COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,36EN6@31979|Clostridiaceae 186801|Clostridia L exonuclease sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,AAA_29,SbcCD_C k141_39_63 1347392.CCEZ01000021_gene849 8.9e-35 119.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,36MMP@31979|Clostridiaceae 186801|Clostridia K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k141_39_64 1410653.JHVC01000032_gene1037 2.12e-83 266.0 COG5492@1|root,COG5492@2|Bacteria,1W2KG@1239|Firmicutes,24FQ5@186801|Clostridia,36E2B@31979|Clostridiaceae 186801|Clostridia N domain, Protein - - - - - - - - - - - - - k141_39_65 195103.CPF_0327 6.29e-281 795.0 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,36DC9@31979|Clostridiaceae 186801|Clostridia L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k141_242_38 1347392.CCEZ01000021_gene841 9.78e-147 427.0 COG1108@1|root,COG1108@2|Bacteria,1TPZB@1239|Firmicutes,2487Y@186801|Clostridia,36GX3@31979|Clostridiaceae 186801|Clostridia P ABC 3 transport family troD - - ko:K09819,ko:K11709,ko:K19976 ko02010,map02010 M00243,M00319,M00792 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.15 - - ABC-3,Fe_dep_repr_C,Fe_dep_repress k141_242_39 350688.Clos_1352 2.5e-76 233.0 COG2096@1|root,COG2096@2|Bacteria,1V3PI@1239|Firmicutes,24C7G@186801|Clostridia,36GUU@31979|Clostridiaceae 186801|Clostridia S adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans,Haem_degrading k141_242_40 1031288.AXAA01000034_gene2175 6.43e-65 213.0 COG2199@1|root,COG3706@2|Bacteria,1TQMM@1239|Firmicutes,24BS4@186801|Clostridia,36FXS@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GAF,GGDEF,SpoOE-like k141_242_42 203119.Cthe_0035 2.18e-78 242.0 COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,3WGU7@541000|Ruminococcaceae 186801|Clostridia C 4Fe-4S binding domain protein - - - - - - - - - - - - Fer4,Fer4_6 k141_242_43 1211817.CCAT010000045_gene3043 0.0 909.0 COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,36DJ5@31979|Clostridiaceae 186801|Clostridia O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k141_242_44 1121324.CLIT_2c03880 5.35e-165 481.0 COG0351@1|root,COG0352@1|root,COG0351@2|Bacteria,COG0352@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia 186801|Clostridia H Phosphomethylpyrimidine kinase thiD - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 ko:K00868,ko:K00941,ko:K14153 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k141_242_46 1121324.CLIT_10c03590 1.45e-60 196.0 COG2230@1|root,COG2230@2|Bacteria,1UMJ8@1239|Firmicutes,25H4D@186801|Clostridia 186801|Clostridia M Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k141_242_47 1540257.JQMW01000009_gene2930 7.71e-94 285.0 COG2996@1|root,COG2996@2|Bacteria,1TQ1Z@1239|Firmicutes,2498C@186801|Clostridia,36EB0@31979|Clostridiaceae 186801|Clostridia S S1, RNA binding domain cvfB - - ko:K00243 - - - - ko00000 - - - S1,S1_2 k141_242_48 1391646.AVSU01000049_gene1648 1.05e-43 151.0 COG3758@1|root,COG3758@2|Bacteria,1VH52@1239|Firmicutes,24P8J@186801|Clostridia,25TMJ@186804|Peptostreptococcaceae 186801|Clostridia S HutD - - - - - - - - - - - - HutD k141_242_49 1347392.CCEZ01000049_gene1387 3.67e-75 232.0 COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,36DKK@31979|Clostridiaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k141_242_51 318464.IO99_00930 2.41e-66 238.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_242_52 1347392.CCEZ01000008_gene2158 3.69e-145 413.0 COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,36E73@31979|Clostridiaceae 186801|Clostridia L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k141_242_53 357809.Cphy_1504 7.29e-158 459.0 2DB7K@1|root,2Z7MK@2|Bacteria,1TQ79@1239|Firmicutes,2489P@186801|Clostridia,21YG7@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF1576) - - - - - - - - - - - - DUF1576 k141_242_55 199310.c5113 4e-52 168.0 COG2824@1|root,COG2824@2|Bacteria,1RGUU@1224|Proteobacteria,1S60W@1236|Gammaproteobacteria,3XPRW@561|Escherichia 1236|Gammaproteobacteria P PhnA Zinc-Ribbon phnA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k141_242_56 536232.CLM_2451 4.53e-186 535.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,36DNW@31979|Clostridiaceae 186801|Clostridia C FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD,NAD_binding_8 k141_242_57 411463.EUBVEN_00797 1.87e-108 324.0 COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia,25VP6@186806|Eubacteriaceae 186801|Clostridia J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k141_242_58 373903.Hore_05190 1.06e-185 532.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WAZ5@53433|Halanaerobiales 186801|Clostridia V efflux protein, MATE family - - - - - - - - - - - - MatE k141_242_59 1190606.AJYG01000011_gene3808 3.72e-38 134.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1XX26@135623|Vibrionales 135623|Vibrionales H Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ada - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,HTH_18 k141_242_60 1123290.AUDQ01000001_gene2896 5.58e-228 645.0 COG1292@1|root,COG1292@2|Bacteria,1TR5F@1239|Firmicutes,4HBSH@91061|Bacilli,26GSI@186818|Planococcaceae 91061|Bacilli M Belongs to the BCCT transporter (TC 2.A.15) family - - - - - - - - - - - - BCCT k141_242_62 1499684.CCNP01000018_gene1215 5.85e-26 100.0 COG1942@1|root,COG1942@2|Bacteria,1VA6U@1239|Firmicutes,24MXT@186801|Clostridia,36KV1@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF1904) - - - - - - - - - - - - DUF1904 k141_242_63 1118059.CAHC01000001_gene625 3.77e-289 826.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WCC2@538999|Clostridiales incertae sedis 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k141_242_64 1227349.C170_01339 2.99e-63 208.0 COG4886@1|root,COG4886@2|Bacteria,1UZCK@1239|Firmicutes,4I6FE@91061|Bacilli,26SQ3@186822|Paenibacillaceae 91061|Bacilli S Leucine Rich repeat - - - - - - - - - - - - LRR_6 k141_242_65 1443125.Z962_05870 2.33e-123 367.0 COG0189@1|root,COG0189@2|Bacteria,1V6GR@1239|Firmicutes,24FXH@186801|Clostridia,36N13@31979|Clostridiaceae 186801|Clostridia HJ ligase activity - - - - - - - - - - - - - k141_242_66 1443125.Z962_05865 2.76e-135 390.0 COG3119@1|root,COG3119@2|Bacteria,1TVD7@1239|Firmicutes,24D8H@186801|Clostridia,36IFG@31979|Clostridiaceae 186801|Clostridia P Sulfatase - - - - - - - - - - - - Sulfatase k141_242_67 526218.Sterm_1642 1.89e-150 441.0 COG0635@1|root,COG0635@2|Bacteria,378ZR@32066|Fusobacteria 2|Bacteria H Involved in the biosynthesis of porphyrin-containing compound hemN1 - - - - - - - - - - - HemN_C,Radical_SAM k141_242_68 1443125.Z962_11630 2.41e-100 302.0 COG0535@1|root,COG0535@2|Bacteria,1V647@1239|Firmicutes,25GQS@186801|Clostridia,36KPP@31979|Clostridiaceae 186801|Clostridia S radical SAM protein - - - - - - - - - - - - - k141_242_69 1123009.AUID01000016_gene21 4.96e-210 586.0 COG1915@1|root,COG1915@2|Bacteria,1TT91@1239|Firmicutes,24A6C@186801|Clostridia,268BA@186813|unclassified Clostridiales 186801|Clostridia S PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - - k141_242_70 1123009.AUID01000016_gene22 7.2e-195 549.0 COG1915@1|root,COG1915@2|Bacteria,1UZ9T@1239|Firmicutes,24CGV@186801|Clostridia,26A2V@186813|unclassified Clostridiales 186801|Clostridia S PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - - k141_242_71 1410653.JHVC01000003_gene3821 2.5e-189 535.0 COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae 186801|Clostridia C aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k141_242_72 617140.AJZE01000093_gene2472 8.9e-53 173.0 COG1051@1|root,COG1051@2|Bacteria,1RB8R@1224|Proteobacteria,1S1A6@1236|Gammaproteobacteria,1XSJ6@135623|Vibrionales 135623|Vibrionales F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k141_242_74 610130.Closa_2758 1.86e-187 543.0 COG2199@1|root,COG2199@2|Bacteria,1UZF7@1239|Firmicutes,25E5Q@186801|Clostridia 186801|Clostridia T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,dCache_1 k141_242_75 1216932.CM240_3303 1.63e-26 123.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia,36GZE@31979|Clostridiaceae 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF k141_242_76 1248232.BANQ01000120_gene329 3.93e-241 674.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1XT5X@135623|Vibrionales 135623|Vibrionales S COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k141_242_77 111780.Sta7437_1135 5.35e-13 72.0 2DIHB@1|root,303AH@2|Bacteria,1GKIS@1117|Cyanobacteria,3VNCG@52604|Pleurocapsales 1117|Cyanobacteria - - - - - - - - - - - - - - - k141_242_78 272563.CD630_10070 2.25e-39 132.0 COG3708@1|root,COG3708@2|Bacteria,1VFMZ@1239|Firmicutes,24RKD@186801|Clostridia,25TVT@186804|Peptostreptococcaceae 186801|Clostridia K Putative zinc ribbon domain - - - - - - - - - - - - Cass2,Zn_ribbon_2 k141_242_79 86416.Clopa_0452 8.07e-89 274.0 COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,25C7I@186801|Clostridia,36E2Q@31979|Clostridiaceae 186801|Clostridia K domain protein - - - - - - - - - - - - HTH_11,WYL k141_242_80 580327.Tthe_1727 6.25e-93 288.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42EQH@68295|Thermoanaerobacterales 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator rbsR - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k141_242_81 469616.FMAG_02323 8.21e-89 274.0 COG0524@1|root,COG0524@2|Bacteria,3791K@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k141_242_82 935836.JAEL01000019_gene879 8.24e-43 144.0 COG1869@1|root,COG1869@2|Bacteria,1VA2V@1239|Firmicutes,4HIFW@91061|Bacilli,1ZGYM@1386|Bacillus 91061|Bacilli G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose rbsD GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034219,GO:0042623,GO:0042626,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702 5.4.99.62 ko:K06726 ko02010,map02010 - R08247 RC02247 ko00000,ko00001,ko01000 - - - RbsD_FucU k141_242_83 469618.FVAG_00841 4.89e-194 557.0 COG1129@1|root,COG1129@2|Bacteria,37997@32066|Fusobacteria 32066|Fusobacteria G Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system rbsA - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran k141_242_84 1301100.HG529275_gene1623 1.75e-126 371.0 COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae 186801|Clostridia G Belongs to the binding-protein-dependent transport system permease family rbsC - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k141_242_85 1511.CLOST_2410 5.1e-142 409.0 COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,25QU7@186804|Peptostreptococcaceae 186801|Clostridia G Periplasmic binding protein domain rbsB - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k141_242_86 1345695.CLSA_c19850 6.22e-187 538.0 COG3344@1|root,COG3344@2|Bacteria,1UZGS@1239|Firmicutes,247Z6@186801|Clostridia,36GER@31979|Clostridiaceae 186801|Clostridia L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k141_242_87 1415774.U728_614 1.88e-264 744.0 COG2345@1|root,COG2345@2|Bacteria,1V0U6@1239|Firmicutes,24AX6@186801|Clostridia,36FKQ@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator - - - - - - - - - - - - SWIM k141_242_88 1345695.CLSA_c19830 5.97e-230 684.0 2EYM2@1|root,33RUP@2|Bacteria,1VRT7@1239|Firmicutes,24CFI@186801|Clostridia,36FKY@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_242_89 266117.Rxyl_1295 3.04e-78 268.0 COG1404@1|root,COG3485@1|root,COG1404@2|Bacteria,COG3485@2|Bacteria,2GJYH@201174|Actinobacteria,4CS04@84995|Rubrobacteria 84995|Rubrobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 k141_242_90 293826.Amet_3753 5.78e-31 129.0 COG0834@1|root,COG2199@1|root,COG2206@1|root,COG0834@2|Bacteria,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,36USB@31979|Clostridiaceae 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - GGDEF,HAMP,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9,dCache_1 k141_242_91 234267.Acid_0019 7.72e-62 229.0 2EY4D@1|root,33RD9@2|Bacteria,3Y6DM@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - k141_242_92 1128398.Curi_c05390 1.91e-23 93.6 2DMI0@1|root,32UH1@2|Bacteria,1VF21@1239|Firmicutes,24VTB@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4282) - - - - - - - - - - - - DUF4282 k141_242_93 397288.C806_01370 8.91e-55 192.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,27J5F@186928|unclassified Lachnospiraceae 186801|Clostridia G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N k141_242_94 332101.JIBU02000050_gene3456 8.8e-246 685.0 COG3104@1|root,COG3104@2|Bacteria,1TP81@1239|Firmicutes,24BI4@186801|Clostridia,36FG1@31979|Clostridiaceae 186801|Clostridia P amino acid peptide transporter - - - - - - - - - - - - PTR2 k141_242_95 1262449.CP6013_2733 1.34e-97 291.0 COG4912@1|root,COG4912@2|Bacteria,1TQII@1239|Firmicutes,248N8@186801|Clostridia,36G61@31979|Clostridiaceae 186801|Clostridia L DNA alkylation repair - - - - - - - - - - - - DNA_alkylation k141_242_96 1007103.AFHW01000076_gene5650 6.09e-32 133.0 28JBJ@1|root,2Z968@2|Bacteria,1V29E@1239|Firmicutes,4HHQC@91061|Bacilli,26UTG@186822|Paenibacillaceae 91061|Bacilli - - M1-1079 - - - - - - - - - - - - k141_242_97 65497.JODV01000025_gene1862 9.66e-26 117.0 COG1020@1|root,COG1020@2|Bacteria,2GWGZ@201174|Actinobacteria,4E0UY@85010|Pseudonocardiales 201174|Actinobacteria Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,PP-binding k141_242_98 935837.JAEK01000005_gene4348 2.39e-103 313.0 COG0332@1|root,COG0332@2|Bacteria,1UYNP@1239|Firmicutes,4HECC@91061|Bacilli,1ZM97@1386|Bacillus 91061|Bacilli I Chalcone and stilbene synthases, N-terminal domain fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k141_242_99 1123252.ATZF01000003_gene3450 3.17e-59 200.0 COG0451@1|root,COG0451@2|Bacteria,1TT3X@1239|Firmicutes,4HFYX@91061|Bacilli 91061|Bacilli M NAD dependent epimerase dehydratase family protein galE1 - - - - - - - - - - - 3Beta_HSD,Epimerase k141_242_100 1333507.AUTQ01000202_gene1057 1.79e-25 108.0 COG0491@1|root,COG0491@2|Bacteria,1QPNG@1224|Proteobacteria,1RSBT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-Beta-Lactamase gumP - - - - - - - - - - - Lactamase_B k141_242_101 888833.HMPREF9421_1462 1.57e-94 298.0 COG1541@1|root,COG1541@2|Bacteria,1UYWT@1239|Firmicutes,4HD2R@91061|Bacilli 91061|Bacilli H Coenzyme F390 synthetase - - - - - - - - - - - - AMP-binding k141_242_103 929506.CbC4_2031 0.0 876.0 COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia,36E0B@31979|Clostridiaceae 186801|Clostridia S ABC transporter ykpA - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k141_242_104 1123511.KB905839_gene528 2.59e-41 149.0 COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,4H61C@909932|Negativicutes 909932|Negativicutes S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k141_242_105 1121324.CLIT_4c01060 2.99e-79 251.0 COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,247X6@186801|Clostridia,25R1J@186804|Peptostreptococcaceae 186801|Clostridia S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 k141_242_106 526218.Sterm_1373 1.56e-121 364.0 COG1690@1|root,COG1690@2|Bacteria,379MD@32066|Fusobacteria 32066|Fusobacteria S tRNA-splicing ligase RtcB - - - - - - - - - - - - RtcB k141_242_107 1033737.CAEV01000089_gene214 2.21e-123 371.0 COG1686@1|root,COG1686@2|Bacteria,1V37K@1239|Firmicutes,247XD@186801|Clostridia,36DEX@31979|Clostridiaceae 186801|Clostridia M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Peptidase_S11 k141_242_108 1540257.JQMW01000009_gene3016 2.54e-169 489.0 COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,25E7A@186801|Clostridia,36E67@31979|Clostridiaceae 186801|Clostridia E amino acid - - - - - - - - - - - - AA_permease_2,Usp k141_242_109 1540257.JQMW01000009_gene3014 3.6e-214 622.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_12,HTH_8,PAS,PAS_8,Sigma54_activat k141_242_110 1321778.HMPREF1982_03163 6.07e-132 410.0 COG1506@1|root,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,249FQ@186801|Clostridia,26AER@186813|unclassified Clostridiales 186801|Clostridia E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 k141_242_111 1033737.CAEV01000043_gene1438 2e-131 386.0 COG0624@1|root,COG0624@2|Bacteria,1TT3H@1239|Firmicutes,25CA7@186801|Clostridia,36WS5@31979|Clostridiaceae 186801|Clostridia E Peptidase dimerisation domain - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k141_242_113 1141106.CAIB01000016_gene122 8.44e-71 244.0 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,4HAMK@91061|Bacilli,4GWY5@90964|Staphylococcaceae 91061|Bacilli E ABC transporter substrate-binding protein oppA - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k141_242_114 985762.SAGN_08083 4.33e-95 290.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HA2S@91061|Bacilli,4GYK4@90964|Staphylococcaceae 91061|Bacilli P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k141_242_115 1385510.N781_15360 1.1e-112 341.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,2Y8RZ@289201|Pontibacillus 91061|Bacilli U Peptide ABC transporter permease oppC - - ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k141_242_116 1246484.D479_15787 6.42e-166 473.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,3NE36@45667|Halobacillus 91061|Bacilli EP Oligopeptide/dipeptide transporter, C-terminal region oppD - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k141_242_117 1301100.HG529378_gene4074 1.32e-156 447.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily oppF - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k141_242_118 1499689.CCNN01000007_gene2186 1.2e-208 599.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36EW0@31979|Clostridiaceae 186801|Clostridia C pyruvate flavodoxin ferredoxin oxidoreductase domain protein korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k141_242_119 457396.CSBG_00933 5.68e-113 334.0 COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,36WSB@31979|Clostridiaceae 186801|Clostridia C PFAM thiamine pyrophosphate protein domain protein TPP-binding korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k141_242_120 1280689.AUJC01000013_gene1776 1.84e-265 769.0 COG1221@1|root,COG3933@1|root,COG1221@2|Bacteria,COG3933@2|Bacteria,1VSHE@1239|Firmicutes,248QH@186801|Clostridia,36ECX@31979|Clostridiaceae 186801|Clostridia K system, fructose subfamily, IIA component - - - - - - - - - - - - EIIA-man,PRD,Sigma54_activat,TrmB k141_242_121 171693.BN988_03173 1.2e-25 99.0 COG1440@1|root,COG1440@2|Bacteria,1VADE@1239|Firmicutes,4HKCQ@91061|Bacilli,23KXS@182709|Oceanobacillus 91061|Bacilli G PTS system, Lactose/Cellobiose specific IIB subunit ydhM - 2.7.1.196,2.7.1.205 ko:K02760 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.3.2 - - PTS_IIB k141_242_122 1094508.Tsac_0114 2.24e-176 506.0 COG1455@1|root,COG1455@2|Bacteria,1TP8D@1239|Firmicutes,24808@186801|Clostridia,42HZE@68295|Thermoanaerobacterales 186801|Clostridia G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane - - - ko:K02761 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.3.2 - - PTS_EIIC k141_242_123 985665.HPL003_00930 7.31e-26 100.0 COG1447@1|root,COG1447@2|Bacteria,1VEGE@1239|Firmicutes,4HM37@91061|Bacilli,26Y4J@186822|Paenibacillaceae 91061|Bacilli G PTS system, Lactose/Cellobiose specific IIA subunit licA - 2.7.1.196,2.7.1.205 ko:K02759 ko00500,ko02060,map00500,map02060 M00275 R11170,R11172 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.3.2 - iYO844.BSU38570 PTS_IIA k141_242_124 555079.Toce_0345 1.36e-144 426.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,42FX4@68295|Thermoanaerobacterales 186801|Clostridia G PFAM glycoside hydrolase, family 4 - - 3.2.1.86 ko:K01222 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT4 - Glyco_hydro_4,Glyco_hydro_4C k141_242_125 632245.CLP_0291 1.02e-147 428.0 COG3589@1|root,COG3589@2|Bacteria,1TRIY@1239|Firmicutes,248R7@186801|Clostridia,36EAB@31979|Clostridiaceae 186801|Clostridia S hmm pf05913 - - - ko:K09963 - - - - ko00000 - - - DUF871 k141_242_126 37659.JNLN01000001_gene804 4.92e-19 99.0 COG2898@1|root,COG2898@2|Bacteria,1U5FR@1239|Firmicutes,248XI@186801|Clostridia,36E5R@31979|Clostridiaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC_tran_2 k141_242_127 1196322.A370_01507 7.41e-87 264.0 COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,36DUF@31979|Clostridiaceae 186801|Clostridia V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_242_128 665571.STHERM_c15110 3.89e-38 144.0 COG0697@1|root,COG0697@2|Bacteria,2J5K6@203691|Spirochaetes 203691|Spirochaetes EG EamA-like transporter family ybfH - - - - - - - - - - - EamA k141_242_129 1321778.HMPREF1982_00754 7.26e-84 268.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,249VN@186801|Clostridia,26BE8@186813|unclassified Clostridiales 186801|Clostridia J Threonine alanine tRNA ligase second additional domain protein alaXL - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k141_242_130 1319815.HMPREF0202_02494 2.98e-190 539.0 COG1301@1|root,COG1301@2|Bacteria,3794D@32066|Fusobacteria 32066|Fusobacteria C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k141_242_131 1121289.JHVL01000039_gene3135 1.62e-53 174.0 COG0348@1|root,COG0348@2|Bacteria,1UHUA@1239|Firmicutes,24BED@186801|Clostridia,36W8I@31979|Clostridiaceae 186801|Clostridia C Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Fer4_5 k141_242_133 1487921.DP68_14285 1.46e-53 187.0 COG4872@1|root,COG4872@2|Bacteria,1TT9X@1239|Firmicutes,24CCI@186801|Clostridia,36GUK@31979|Clostridiaceae 186801|Clostridia S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k141_193_85 1031288.AXAA01000010_gene454 2.14e-20 103.0 COG0840@1|root,COG0840@2|Bacteria,1URS2@1239|Firmicutes,24B7E@186801|Clostridia,36H9N@31979|Clostridiaceae 186801|Clostridia NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k141_193_86 1280673.AUJJ01000005_gene328 2.32e-21 103.0 COG3437@1|root,COG3437@2|Bacteria,1UX7W@1239|Firmicutes,25P74@186801|Clostridia,4BXGG@830|Butyrivibrio 186801|Clostridia T Histidine Phosphotransfer domain - - - - - - - - - - - - HD,HisKA,Hpt,Response_reg k141_193_87 350688.Clos_0240 1.71e-82 251.0 COG3859@1|root,COG3859@2|Bacteria,1V1WX@1239|Firmicutes,24E4Z@186801|Clostridia,36IVJ@31979|Clostridiaceae 186801|Clostridia S Proton-coupled thiamine transporter YuaJ yuaJ - - ko:K16789 - - - - ko00000,ko02000 2.A.88.3 - - Thia_YuaJ k141_193_88 1229520.ADIAL_2091 5.73e-34 142.0 COG0651@1|root,COG0651@2|Bacteria,1TRAT@1239|Firmicutes,4HA10@91061|Bacilli,27FAQ@186828|Carnobacteriaceae 91061|Bacilli CP Proton-conducting membrane transporter mrpD GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - iSB619.SA_RS04615 Proton_antipo_M k141_193_89 1499967.BAYZ01000028_gene1295 1.97e-17 78.6 COG1006@1|root,COG1006@2|Bacteria,2NQ57@2323|unclassified Bacteria 2|Bacteria P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k141_193_90 318167.Sfri_2284 5.01e-05 48.9 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,2Q9B0@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM Na H antiporter MnhB subunit-related protein - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k141_193_91 1304284.L21TH_0053 8.57e-11 60.1 COG2111@1|root,COG2111@2|Bacteria,1VPIK@1239|Firmicutes,24VEZ@186801|Clostridia 186801|Clostridia P Na H antiporter - - - - - - - - - - - - - k141_193_92 1499967.BAYZ01000028_gene1300 2.19e-09 58.5 COG1563@1|root,COG1563@2|Bacteria,2NRSK@2323|unclassified Bacteria 2|Bacteria P Domain of unknown function (DUF4040) mnhB - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k141_193_93 293826.Amet_4157 2.54e-05 46.6 COG1320@1|root,COG1320@2|Bacteria,1VHQ3@1239|Firmicutes,24RQT@186801|Clostridia,36KTJ@31979|Clostridiaceae 186801|Clostridia P Na+/H+ antiporter subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k141_193_94 1286171.EAL2_c20680 1.75e-05 45.1 COG2212@1|root,COG2212@2|Bacteria,1VH97@1239|Firmicutes,24T3T@186801|Clostridia 186801|Clostridia P Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k141_193_95 1307761.L21SP2_1997 2.26e-10 63.2 COG1863@1|root,COG1863@2|Bacteria,2J884@203691|Spirochaetes 203691|Spirochaetes P Na+/H+ ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k141_193_96 1443122.Z958_08455 2.09e-179 525.0 COG0076@1|root,COG0076@2|Bacteria,1TRVW@1239|Firmicutes,25D2Y@186801|Clostridia,36GDE@31979|Clostridiaceae 186801|Clostridia E Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k141_193_97 1321778.HMPREF1982_01868 5.39e-205 580.0 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,268DU@186813|unclassified Clostridiales 186801|Clostridia J Psort location Cytoplasmic, score 10.00 hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k141_193_98 865861.AZSU01000006_gene1386 7.44e-41 167.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - EAL,GGDEF,PAS_9,SBP_bac_3 k141_193_99 1230342.CTM_10983 7.23e-108 343.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - ABC_sub_bind,EAL,GGDEF,PAS_3,PAS_9,PocR k141_193_101 1121324.CLIT_4c00300 4.49e-147 427.0 COG0240@1|root,COG0240@2|Bacteria,1TUSI@1239|Firmicutes,249QW@186801|Clostridia,25TGI@186804|Peptostreptococcaceae 186801|Clostridia C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain odh - 1.5.1.28 ko:K04940 - - - - ko00000,ko01000 - - - ApbA,NAD_Gly3P_dh_N,Octopine_DH k141_79_2 879305.HMPREF9290_1598 1.19e-84 276.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,22G68@1570339|Peptoniphilaceae 186801|Clostridia NU Type II IV secretion system protein gspE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k141_79_3 1121324.CLIT_8c00450 1.7e-244 687.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia 186801|Clostridia E Family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k141_79_4 1121324.CLIT_8c00490 9.76e-109 323.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia 186801|Clostridia P ABC-type dipeptide oligopeptide nickel transport - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k141_79_5 1121324.CLIT_8c00500 3.09e-137 398.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,25TJK@186804|Peptostreptococcaceae 186801|Clostridia U Binding-protein-dependent transport system inner membrane component oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k141_79_6 935845.JADQ01000036_gene2929 7.79e-220 618.0 COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,4H9U7@91061|Bacilli,26SYZ@186822|Paenibacillaceae 91061|Bacilli P NADH oxidase nox - 1.6.3.4 ko:K17869 - - - - ko00000,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k141_79_8 1391646.AVSU01000001_gene288 9.59e-84 266.0 COG0457@1|root,COG0457@2|Bacteria,1V96X@1239|Firmicutes,24AK3@186801|Clostridia,25QFT@186804|Peptostreptococcaceae 186801|Clostridia S TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 k141_79_9 445973.CLOBAR_01278 2.58e-211 608.0 COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,25T1I@186804|Peptostreptococcaceae 186801|Clostridia C Protein of unknown function (DUF4080) - - 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,DUF4080,Radical_SAM k141_79_10 1286171.EAL2_c09060 5.79e-16 71.6 2E5P9@1|root,330DZ@2|Bacteria,1VFDT@1239|Firmicutes,24SYS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_79_12 1121324.CLIT_5c00200 2.06e-283 789.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,25QY6@186804|Peptostreptococcaceae 186801|Clostridia J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k141_79_13 1121324.CLIT_5c00130 1.16e-142 414.0 COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,249TX@186801|Clostridia,25QMN@186804|Peptostreptococcaceae 186801|Clostridia C dehydrogenase (FMN-dependent) lldD - - - - - - - - - - - FMN_dh k141_79_14 1151292.QEW_1119 1.27e-51 167.0 COG1683@1|root,COG1683@2|Bacteria,1V700@1239|Firmicutes,24JD2@186801|Clostridia,25RKG@186804|Peptostreptococcaceae 186801|Clostridia S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 k141_79_15 1391646.AVSU01000001_gene282 1.28e-307 868.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,25QHB@186804|Peptostreptococcaceae 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k141_79_16 555079.Toce_0459 1.18e-100 312.0 COG0642@1|root,COG2205@2|Bacteria,1UITD@1239|Firmicutes,25EZC@186801|Clostridia 186801|Clostridia T PFAM ATP-binding region - - 2.7.13.3 ko:K07717 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c k141_79_17 324057.Pjdr2_2879 4.03e-40 149.0 COG4753@1|root,COG4753@2|Bacteria,1TPFP@1239|Firmicutes,4HFB4@91061|Bacilli,26SCM@186822|Paenibacillaceae 91061|Bacilli T YcbB domain ycbB1 - - ko:K07719 ko02020,map02020 M00518 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,YcbB k141_79_18 555079.Toce_0461 2.19e-143 420.0 COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia 186801|Clostridia P Catalyzes the sodium-dependent transport of glutamate gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k141_79_19 1151292.QEW_1112 4.83e-187 562.0 COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,25QXR@186804|Peptostreptococcaceae 186801|Clostridia O Peptidase, U32 family ydcP - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 k141_79_20 398512.JQKC01000002_gene1797 5.31e-18 82.8 COG3027@1|root,COG3027@2|Bacteria,1VFZR@1239|Firmicutes,25B8U@186801|Clostridia,3WS5E@541000|Ruminococcaceae 186801|Clostridia D Cell division protein ZapA - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k141_79_21 1476973.JMMB01000007_gene583 6.4e-313 882.0 COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,25QNW@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind k141_79_22 500633.CLOHIR_01898 3.39e-163 466.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,25R7N@186804|Peptostreptococcaceae 186801|Clostridia J Phenylalanyl-tRNA synthetase alpha subunit pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k141_79_23 596329.HMPREF0631_1453 1.16e-59 196.0 COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,25RAX@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k141_79_24 1121324.CLIT_10c02590 6.03e-111 323.0 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,25R8D@186804|Peptostreptococcaceae 186801|Clostridia P TrkA N-terminal domain protein ktrC - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k141_79_25 1121324.CLIT_10c02600 6.01e-203 575.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,25T7G@186804|Peptostreptococcaceae 186801|Clostridia P Cation transport protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k141_79_26 293826.Amet_1635 2.38e-67 205.0 COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,36ITT@31979|Clostridiaceae 186801|Clostridia J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k141_79_27 714961.BFZC1_05668 2.4e-20 82.8 COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,4HNIQ@91061|Bacilli,3IYJB@400634|Lysinibacillus 91061|Bacilli J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k141_79_28 1121324.CLIT_10c02630 4.97e-66 204.0 COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia 186801|Clostridia J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k141_79_29 1151292.QEW_0834 0.0 1016.0 COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,25QSG@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k141_79_30 1392493.JIAB01000001_gene1043 6e-64 216.0 COG2208@1|root,COG2208@2|Bacteria,1TQUC@1239|Firmicutes,248FZ@186801|Clostridia,27JYM@186928|unclassified Lachnospiraceae 186801|Clostridia KT Stage II sporulation protein E (SpoIIE) - - - - - - - - - - - - SpoIIE k141_79_31 1121324.CLIT_10c02690 2.19e-61 219.0 COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,25KCE@186801|Clostridia,25SAF@186804|Peptostreptococcaceae 186801|Clostridia C Putative Fe-S cluster - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4 k141_79_34 1511.CLOST_1121 1.48e-152 437.0 COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,25R77@186804|Peptostreptococcaceae 186801|Clostridia S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k141_79_35 1511.CLOST_1120 3.48e-154 444.0 COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,25QBZ@186804|Peptostreptococcaceae 186801|Clostridia S Branched-chain amino acid transport system / permease component rbsC - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k141_79_36 1304284.L21TH_2351 1.11e-271 755.0 COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae 186801|Clostridia S ABC transporter rbsA2 - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k141_79_37 1511.CLOST_1117 8.24e-140 407.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,25S1Q@186804|Peptostreptococcaceae 186801|Clostridia S ABC transporter substrate-binding protein PnrA-like bmpA - - ko:K07335 - - - - ko00000 - - - Bmp k141_124_1 1430331.EP10_18000 1.05e-42 150.0 COG5585@1|root,COG5585@2|Bacteria,1V80F@1239|Firmicutes,4HJQD@91061|Bacilli 91061|Bacilli T COG3209 Rhs family protein - - - - - - - - - - - - - k141_124_2 1196324.A374_01509 4.88e-37 131.0 2E36E@1|root,32Y65@2|Bacteria,1VHZX@1239|Firmicutes,4HN2V@91061|Bacilli 91061|Bacilli S Immunity protein 30 - - - - - - - - - - - - Imm30 k141_124_4 1280689.AUJC01000004_gene341 6.2e-173 532.0 COG3325@1|root,COG3325@2|Bacteria,1UPJ7@1239|Firmicutes,24D95@186801|Clostridia,36EAZ@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 18 family - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - CHB_HEX_C_1,ChitinaseA_N,Glyco_hydro_18 k141_124_5 1540257.JQMW01000013_gene1163 1.54e-209 594.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,36F13@31979|Clostridiaceae 186801|Clostridia E amino acid carrier protein glnT - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k141_124_6 1511.CLOST_1823 2.93e-140 405.0 COG2066@1|root,COG2066@2|Bacteria,1TP64@1239|Firmicutes,2491K@186801|Clostridia,25S53@186804|Peptostreptococcaceae 186801|Clostridia E Glutaminase glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase k141_124_7 1487921.DP68_16615 6.41e-189 541.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,36EVK@31979|Clostridiaceae 186801|Clostridia T Two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k141_124_8 1230342.CTM_11790 1.89e-106 334.0 COG5000@1|root,COG5000@2|Bacteria,1V3IT@1239|Firmicutes,249GI@186801|Clostridia,36FPA@31979|Clostridiaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_124_9 1487921.DP68_16625 1.29e-63 219.0 COG0840@1|root,COG0840@2|Bacteria,1US07@1239|Firmicutes,24Y5V@186801|Clostridia,36RB8@31979|Clostridiaceae 186801|Clostridia NT Cache domain - - - - - - - - - - - - dCache_1 k141_124_10 536232.CLM_0798 4.09e-115 341.0 COG2367@1|root,COG2367@2|Bacteria,1TQFB@1239|Firmicutes,249R7@186801|Clostridia,36F9K@31979|Clostridiaceae 186801|Clostridia V Beta-lactamase - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k141_124_11 997346.HMPREF9374_3946 1.27e-106 341.0 COG2602@1|root,COG4219@1|root,COG2602@2|Bacteria,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,4HB9X@91061|Bacilli 91061|Bacilli KT signal transduction N-terminal membrane component mecR1 - - ko:K02172,ko:K02547 ko01501,map01501 M00625,M00627 - - ko00000,ko00001,ko00002,ko01002,ko01504 - - - Peptidase_M56,Transpeptidase k141_124_12 748727.CLJU_c13470 1.23e-46 154.0 COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,24N11@186801|Clostridia,36J44@31979|Clostridiaceae 186801|Clostridia K Penicillinase repressor blaI - - ko:K02171 ko01501,map01501 M00627 - - ko00000,ko00001,ko00002,ko01504,ko03000 - - - Penicillinase_R k141_124_13 1121342.AUCO01000015_gene2647 1.08e-140 439.0 COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,36E3M@31979|Clostridiaceae 186801|Clostridia L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2 k141_124_14 536227.CcarbDRAFT_2536 1.87e-93 279.0 COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia,36FNS@31979|Clostridiaceae 186801|Clostridia C LUD domain - - - - - - - - - - - - LUD_dom k141_124_15 1121324.CLIT_24c00180 0.0 991.0 COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,25QC3@186804|Peptostreptococcaceae 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k141_124_17 1292035.H476_3235 4.67e-244 682.0 COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,25QNQ@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase,QRPTase_C,QRPTase_N k141_124_18 1280692.AUJL01000019_gene924 5.91e-41 136.0 COG2002@1|root,COG2002@2|Bacteria,1VA3H@1239|Firmicutes,24MN7@186801|Clostridia,36KGI@31979|Clostridiaceae 186801|Clostridia K AbrB family NPD5_2057 - - ko:K06284 - - - - ko00000,ko03000 - - - MazE_antitoxin k141_124_19 866895.HBHAL_1052 2.7e-87 269.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,4HAH8@91061|Bacilli,3NE9G@45667|Halobacillus 91061|Bacilli H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k141_124_20 1151292.QEW_4174 2.26e-113 332.0 COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,25QWN@186804|Peptostreptococcaceae 186801|Clostridia S Methyltransferase domain yfiC - 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS,Methyltransf_31 k141_124_22 1121324.CLIT_24c00280 7.91e-251 701.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,25S4A@186804|Peptostreptococcaceae 186801|Clostridia S Sodium neurotransmitter symporter family protein - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k141_124_24 1121324.CLIT_24c00290 7.71e-138 402.0 COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,25QP1@186804|Peptostreptococcaceae 186801|Clostridia S PSP1 C-terminal domain protein yaaT - - - - - - - - - - - PSP1 k141_124_25 1408324.JNJK01000019_gene2533 1.26e-44 162.0 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,27IHW@186928|unclassified Lachnospiraceae 186801|Clostridia L DNA polymerase III, delta subunit holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k141_124_26 1391646.AVSU01000045_gene1464 1.12e-111 326.0 COG0125@1|root,COG0125@2|Bacteria,1V2D5@1239|Firmicutes,25J57@186801|Clostridia,25QYY@186804|Peptostreptococcaceae 186801|Clostridia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k141_124_28 445335.CBN_2141 1.1e-59 205.0 COG1403@1|root,COG1403@2|Bacteria,1VFQ8@1239|Firmicutes,25AX9@186801|Clostridia,36MCQ@31979|Clostridiaceae 186801|Clostridia V HNH endonuclease - - - - - - - - - - - - - k141_124_29 485916.Dtox_1424 2.98e-57 214.0 COG3950@1|root,COG3950@2|Bacteria,1VHTQ@1239|Firmicutes,24R73@186801|Clostridia 186801|Clostridia L AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21 k141_124_31 1286171.EAL2_808p03650 3.26e-115 336.0 COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,25W5Y@186806|Eubacteriaceae 186801|Clostridia O C-terminal domain of 1-Cys peroxiredoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k141_124_32 562743.JH976443_gene3410 6.63e-61 190.0 COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,4HH3B@91061|Bacilli 91061|Bacilli J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k141_124_33 1286171.EAL2_c01920 3.99e-70 214.0 COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,25WEH@186806|Eubacteriaceae 186801|Clostridia J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k141_124_34 411489.CLOL250_02274 1.86e-67 215.0 COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,36DP0@31979|Clostridiaceae 186801|Clostridia J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k141_124_35 1511.CLOST_2164 1.76e-122 357.0 COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,25QTH@186804|Peptostreptococcaceae 186801|Clostridia P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfT - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ k141_124_36 1262449.CP6013_0878 1.4e-124 363.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,36F0E@31979|Clostridiaceae 186801|Clostridia P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfA - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k141_124_37 1035196.HMPREF9998_00697 2.58e-139 401.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,25R7X@186804|Peptostreptococcaceae 186801|Clostridia P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfA - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k141_124_38 445973.CLOBAR_00122 1.78e-57 180.0 COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,25RDK@186804|Peptostreptococcaceae 186801|Clostridia J 50S ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k141_124_39 500633.CLOHIR_01604 3.96e-180 506.0 COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,25QH3@186804|Peptostreptococcaceae 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k141_124_40 1286171.EAL2_c01850 6.58e-114 330.0 COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,25VYW@186806|Eubacteriaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k141_243_192 335541.Swol_1142 2.47e-214 653.0 COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,42JQK@68298|Syntrophomonadaceae 186801|Clostridia L Belongs to the helicase family. AddB RexB type 1 subfamily addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD-helicase,UvrD_C k141_243_193 350688.Clos_2290 1.98e-301 884.0 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,36E2W@31979|Clostridiaceae 186801|Clostridia L ATP-dependent helicase nuclease subunit A addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k141_243_194 1151292.QEW_0214 5.58e-79 249.0 COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia,25TFV@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k141_243_195 1443125.Z962_03380 8.21e-56 178.0 COG0716@1|root,COG0716@2|Bacteria,1V6D7@1239|Firmicutes,24J7W@186801|Clostridia,36JTC@31979|Clostridiaceae 186801|Clostridia C flavodoxin - - - - - - - - - - - - Flavodoxin_1 k141_243_196 1353529.M899_1199 9.82e-31 131.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07644 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_9,Response_reg k141_243_197 1280685.AUKC01000054_gene1426 2.35e-100 298.0 COG0745@1|root,COG0745@2|Bacteria,1TPRU@1239|Firmicutes,24843@186801|Clostridia,4BX95@830|Butyrivibrio 186801|Clostridia T Transcriptional regulatory protein, C terminal srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C k141_113_32 1340434.AXVA01000026_gene4112 7.81e-120 366.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli,1ZDIH@1386|Bacillus 91061|Bacilli S amidohydrolase abgB - - ko:K12941,ko:K21613 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k141_113_33 1345695.CLSA_c04600 1.27e-164 495.0 COG3590@1|root,COG3590@2|Bacteria,1TQTA@1239|Firmicutes,2482M@186801|Clostridia,36E8B@31979|Clostridiaceae 186801|Clostridia O PFAM peptidase pepO1 - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k141_113_34 1235799.C818_00717 9.68e-35 125.0 COG4087@1|root,COG4087@2|Bacteria,1VA72@1239|Firmicutes,24N3C@186801|Clostridia,27PCV@186928|unclassified Lachnospiraceae 186801|Clostridia S Soluble P-type ATPase - - - - - - - - - - - - Hydrolase,Hydrolase_3 k141_113_35 1385514.N782_07640 4.84e-65 216.0 COG2113@1|root,COG2113@2|Bacteria,1TP82@1239|Firmicutes,4HE25@91061|Bacilli,2YB7B@289201|Pontibacillus 91061|Bacilli E ABC transporter substrate-binding protein - - - ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k141_113_36 673860.AciM339_0292 3.57e-62 226.0 COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03614@2157|Archaea,2XZI4@28890|Euryarchaeota 28890|Euryarchaeota O Papain family cysteine protease - - - - - - - - - - - - Peptidase_C1 k141_113_37 744872.Spica_0213 5.79e-20 91.7 COG2197@1|root,COG2197@2|Bacteria,2JAGN@203691|Spirochaetes 203691|Spirochaetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k141_113_38 349521.HCH_03563 2.34e-119 363.0 28M1K@1|root,2ZAGC@2|Bacteria,1R54U@1224|Proteobacteria,1S1SJ@1236|Gammaproteobacteria,1XNPE@135619|Oceanospirillales 135619|Oceanospirillales S Aerolysin toxin - - - - - - - - - - - - Aerolysin k141_113_39 1121935.AQXX01000114_gene3231 4.12e-94 298.0 28M1K@1|root,2ZAGC@2|Bacteria,1R54U@1224|Proteobacteria,1S1SJ@1236|Gammaproteobacteria,1XNPE@135619|Oceanospirillales 135619|Oceanospirillales S Aerolysin toxin - - - - - - - - - - - - Aerolysin k141_145_3 1304866.K413DRAFT_2576 5.59e-64 200.0 COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,25B12@186801|Clostridia,36WI4@31979|Clostridiaceae 186801|Clostridia K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k141_145_4 1280692.AUJL01000001_gene124 1.8e-38 134.0 COG5660@1|root,COG5660@2|Bacteria,1V87D@1239|Firmicutes,24NAR@186801|Clostridia,36M52@31979|Clostridiaceae 186801|Clostridia S Putative zinc-finger - - - - - - - - - - - - DUF3955,zf-HC2 k141_38_3 1230342.CTM_06731 1.07e-187 536.0 COG0534@1|root,COG0534@2|Bacteria,1TPPJ@1239|Firmicutes,25AZE@186801|Clostridia,36ESK@31979|Clostridiaceae 186801|Clostridia V MatE - - - - - - - - - - - - MatE k141_38_8 392499.Swit_3481 7.89e-20 100.0 COG4928@1|root,COG4928@2|Bacteria,1MWRP@1224|Proteobacteria,2VBBP@28211|Alphaproteobacteria,2KB6V@204457|Sphingomonadales 204457|Sphingomonadales S KAP family P-loop domain - - - - - - - - - - - - KAP_NTPase k141_38_9 1454007.JAUG01000091_gene691 3.6e-14 83.2 COG0793@1|root,COG0793@2|Bacteria,4NGGJ@976|Bacteroidetes,1ITFP@117747|Sphingobacteriia 976|Bacteroidetes M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k141_38_10 796606.BMMGA3_08670 1.14e-41 141.0 COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,1ZQA5@1386|Bacillus 91061|Bacilli K Transcriptional regulator ytrA - - ko:K07979 - - - - ko00000,ko03000 - - - GntR k141_38_11 332101.JIBU02000097_gene4099 3.89e-116 343.0 COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia,36DSS@31979|Clostridiaceae 186801|Clostridia V ABC transporter ytrB - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_38_12 1408422.JHYF01000016_gene47 1.91e-64 233.0 COG1277@1|root,COG1277@2|Bacteria,1TRJ8@1239|Firmicutes,24EMN@186801|Clostridia,36UPT@31979|Clostridiaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - - k141_38_13 203119.Cthe_0245 1.57e-52 168.0 COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,3WK18@541000|Ruminococcaceae 186801|Clostridia K regulatory protein, arsR ziaR - - ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 k141_38_14 521045.Kole_1249 1.05e-52 171.0 COG1225@1|root,COG1225@2|Bacteria,2GD74@200918|Thermotogae 200918|Thermotogae O AhpC/TSA family - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA,Nitroreductase k141_38_15 883.DvMF_2481 2.26e-45 150.0 COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Desulfoferrodoxin ferrous iron-binding region dfx - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrod_N,Desulfoferrodox k141_38_16 926561.KB900617_gene1208 7.59e-99 291.0 COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3WC58@53433|Halanaerobiales 186801|Clostridia C Ferritin-like domain rbr GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - - - - - - - - - - Rubrerythrin k141_38_17 1195236.CTER_2579 1.18e-55 184.0 COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,3WIW5@541000|Ruminococcaceae 186801|Clostridia K Cyclic nucleotide-binding domain protein - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k141_38_18 1128398.Curi_c24040 1.69e-273 763.0 COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,267Y7@186813|unclassified Clostridiales 186801|Clostridia C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k141_53_1 1356852.N008_11730 2.77e-23 112.0 28JDN@1|root,2Z97Y@2|Bacteria,4NKYU@976|Bacteroidetes 976|Bacteroidetes H DisA bacterial checkpoint controller nucleotide-binding - - - - - - - - - - - - DisA_N k141_53_2 1321778.HMPREF1982_01510 5.48e-125 373.0 COG0477@1|root,COG2814@2|Bacteria,1UZKT@1239|Firmicutes,25EHZ@186801|Clostridia,26BZA@186813|unclassified Clostridiales 186801|Clostridia EGP Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MFS_1 k141_53_3 86416.Clopa_4742 6.66e-122 354.0 COG3860@1|root,COG3860@2|Bacteria,1TPHH@1239|Firmicutes,248KK@186801|Clostridia,36DNA@31979|Clostridiaceae 186801|Clostridia K regulatory protein, LuxR - - - - - - - - - - - - DUF2087,GerE k141_53_5 1209989.TepiRe1_2752 1.64e-40 141.0 COG1853@1|root,COG1853@2|Bacteria,1V4IU@1239|Firmicutes,25B2Z@186801|Clostridia,42HFU@68295|Thermoanaerobacterales 186801|Clostridia S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k141_53_6 484770.UFO1_3492 3.92e-06 49.7 COG0583@1|root,COG0583@2|Bacteria,1TRYW@1239|Firmicutes,4H590@909932|Negativicutes 909932|Negativicutes K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k141_53_7 926561.KB900618_gene13 8.15e-122 355.0 COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,24F6M@186801|Clostridia,3WC0T@53433|Halanaerobiales 186801|Clostridia S Putative esterase - - - - - - - - - - - - Esterase k141_53_8 272562.CA_C1468 7.19e-40 137.0 COG0454@1|root,COG0456@2|Bacteria,1VAFS@1239|Firmicutes,24MUI@186801|Clostridia,36JGA@31979|Clostridiaceae 186801|Clostridia K acetyltransferase - - - ko:K03826 - - - - ko00000,ko01000 - - - Acetyltransf_10 k141_53_10 1410653.JHVC01000026_gene303 1.31e-42 148.0 2CD6A@1|root,33WZJ@2|Bacteria,1VW1A@1239|Firmicutes,24JX9@186801|Clostridia,36K20@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_53_13 411902.CLOBOL_02239 9.79e-60 213.0 COG4870@1|root,COG4870@2|Bacteria,1TVCW@1239|Firmicutes,248WA@186801|Clostridia,21ZAU@1506553|Lachnoclostridium 186801|Clostridia O Papain family cysteine protease - - - - - - - - - - - - Big_2,Cu_amine_oxidN1,Peptidase_C1,Rhodanese k141_53_14 180332.JTGN01000007_gene3839 1.26e-84 255.0 COG1395@1|root,COG1395@2|Bacteria,1UY6T@1239|Firmicutes,24FX9@186801|Clostridia 186801|Clostridia K helix-turn-helix - - - - - - - - - - - - Desulfoferrodox,HTH_3 k141_53_16 573061.Clocel_0184 2.16e-192 536.0 COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,36EMC@31979|Clostridiaceae 186801|Clostridia L Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k141_53_17 37659.JNLN01000001_gene1189 1.88e-180 514.0 COG3177@1|root,COG3177@2|Bacteria,1UZBJ@1239|Firmicutes,24M2J@186801|Clostridia 186801|Clostridia S Fic/DOC family - - - - - - - - - - - - Fic k141_53_18 1123009.AUID01000014_gene1795 4.71e-94 290.0 COG2944@1|root,COG2944@2|Bacteria,1UZ9K@1239|Firmicutes,25EFY@186801|Clostridia 186801|Clostridia K PFAM helix-turn-helix domain protein - - - - - - - - - - - - DUF4065,HTH_3,MqsA_antitoxin k141_53_21 445974.CLORAM_01650 4.19e-159 459.0 COG1403@1|root,COG1403@2|Bacteria,1VTXJ@1239|Firmicutes 1239|Firmicutes L HNH nucleases - - - - - - - - - - - - HNH k141_53_22 1511.CLOST_2533 4.96e-79 238.0 COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,25RPM@186804|Peptostreptococcaceae 186801|Clostridia J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k141_53_24 1033737.CAEV01000110_gene1179 7.36e-171 494.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae 186801|Clostridia C Na H antiporter - - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k141_53_26 926554.KI912675_gene2204 8.07e-09 65.1 COG1835@1|root,COG1835@2|Bacteria 2|Bacteria I transferase activity, transferring acyl groups other than amino-acyl groups - - - - - - - - - - - - Acyl_transf_3 k141_53_27 1384057.CD33_10965 3.04e-57 200.0 COG0789@1|root,COG0789@2|Bacteria,1V12J@1239|Firmicutes,4HTTQ@91061|Bacilli 91061|Bacilli K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1,Methyltransf_31 k141_53_29 96561.Dole_1154 1.81e-10 70.5 COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,42TI1@68525|delta/epsilon subdivisions,2WQ9N@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Ankyrin - - - - - - - - - - - - Ank,Ank_2,Ank_3,Ank_4,Ank_5 k141_53_30 177439.DP2071 4.98e-125 390.0 COG1879@1|root,COG3437@1|root,COG1879@2|Bacteria,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42PB6@68525|delta/epsilon subdivisions,2WJJ9@28221|Deltaproteobacteria,2MHWZ@213118|Desulfobacterales 28221|Deltaproteobacteria T Domain of unknown function (DUF3369) - - - - - - - - - - - - DUF3369,HD,HD_5,Response_reg k141_53_32 1121324.CLIT_10c04190 1.57e-106 324.0 COG5438@1|root,COG5438@2|Bacteria,1TPEV@1239|Firmicutes,249SW@186801|Clostridia 186801|Clostridia S YibE F family protein - - - - - - - - - - - - YibE_F k141_53_33 411490.ANACAC_00836 1.03e-66 210.0 COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia 186801|Clostridia O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k141_53_35 1540257.JQMW01000013_gene1106 7e-169 484.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,36EP2@31979|Clostridiaceae 186801|Clostridia E TIGRFAM cysteine desulfurase family protein csd - - - - - - - - - - - Aminotran_5 k141_53_38 1319815.HMPREF0202_02853 1.03e-147 429.0 COG0675@1|root,COG0675@2|Bacteria,379SD@32066|Fusobacteria 32066|Fusobacteria L transposase IS891 IS1136 IS1341 family - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k141_53_39 289376.THEYE_A1198 3.22e-129 385.0 COG0057@1|root,COG0057@2|Bacteria,3J0D8@40117|Nitrospirae 40117|Nitrospirae C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k141_53_41 1121289.JHVL01000042_gene3089 0.000366 51.6 COG0845@1|root,COG0845@2|Bacteria,1UZZV@1239|Firmicutes,24AQV@186801|Clostridia,36W1J@31979|Clostridiaceae 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k141_53_42 1280696.ATVY01000032_gene1392 2.29e-71 231.0 COG0395@1|root,COG0395@2|Bacteria,1TS82@1239|Firmicutes,2488S@186801|Clostridia,4BX6P@830|Butyrivibrio 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k141_53_43 1408422.JHYF01000018_gene1762 4.71e-61 201.0 COG1175@1|root,COG1175@2|Bacteria,1TQTC@1239|Firmicutes,24AQX@186801|Clostridia,36GI8@31979|Clostridiaceae 186801|Clostridia G ABC transporter, permease protein - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k141_53_44 1120998.AUFC01000009_gene2067 7.1e-38 151.0 COG1653@1|root,COG1653@2|Bacteria,1V2J4@1239|Firmicutes,25B5X@186801|Clostridia 186801|Clostridia G Extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 k141_148_2 1408422.JHYF01000014_gene264 2.11e-50 166.0 COG4508@1|root,COG4508@2|Bacteria 2|Bacteria S dUTPase - - - - - - - - - - - - dUTPase_2 k141_162_1 1235796.C815_01073 1.02e-21 89.7 COG2452@1|root,COG2452@2|Bacteria,1UZ1U@1239|Firmicutes 1239|Firmicutes L Resolvase, N-terminal - - - - - - - - - - - - MerR,MerR_1,Resolvase k141_162_2 1121090.KB894709_gene1594 3.89e-106 313.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,1ZB2E@1386|Bacillus 91061|Bacilli E COG1126 ABC-type polar amino acid transport system, ATPase component - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k141_162_3 1286171.EAL2_c17450 2.24e-103 306.0 COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,25W65@186806|Eubacteriaceae 186801|Clostridia P ABC transporter, permease protein - - - ko:K02029,ko:K02030,ko:K10040 ko02010,map02010 M00228,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k141_73_23 332101.JIBU02000023_gene4644 5.59e-298 831.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,248V6@186801|Clostridia,36DXV@31979|Clostridiaceae 186801|Clostridia G PTS system, fructose subfamily fruA - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB k141_73_24 1511.CLOST_0051 3.95e-228 637.0 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,25QWP@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k141_73_25 1480694.DC28_04470 2.37e-38 150.0 COG0683@1|root,COG0683@2|Bacteria,2JADP@203691|Spirochaetes 203691|Spirochaetes E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k141_73_26 1480694.DC28_04470 2.39e-12 72.4 COG0683@1|root,COG0683@2|Bacteria,2JADP@203691|Spirochaetes 203691|Spirochaetes E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k141_73_28 1480694.DC28_04470 2.25e-37 147.0 COG0683@1|root,COG0683@2|Bacteria,2JADP@203691|Spirochaetes 203691|Spirochaetes E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k141_73_29 1480694.DC28_04470 1.21e-21 103.0 COG0683@1|root,COG0683@2|Bacteria,2JADP@203691|Spirochaetes 203691|Spirochaetes E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k141_73_30 1511.CLOST_2435 1.26e-47 186.0 COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria,1UCKT@1239|Firmicutes,24GBZ@186801|Clostridia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k141_73_31 1121324.CLIT_4c01500 8.66e-44 147.0 2A59T@1|root,30TYZ@2|Bacteria,1UQ2N@1239|Firmicutes,24SKP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_73_32 1444310.JANV01000138_gene1992 1.73e-56 191.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli,1ZBDV@1386|Bacillus 91061|Bacilli S COG1073 Hydrolases of the alpha beta superfamily - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k141_73_33 1158614.I592_00575 3.69e-47 158.0 COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,4HH7S@91061|Bacilli,4B2BB@81852|Enterococcaceae 91061|Bacilli F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k141_191_13 1033810.HLPCO_001459 1.4e-77 241.0 COG0289@1|root,COG0289@2|Bacteria,2NPX5@2323|unclassified Bacteria 2|Bacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1520 DapB_C,DapB_N k141_191_14 1499684.CCNP01000020_gene2496 8.22e-127 370.0 COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,36DMX@31979|Clostridiaceae 186801|Clostridia E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k141_191_15 536227.CcarbDRAFT_1027 1.46e-167 476.0 COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,36DDT@31979|Clostridiaceae 186801|Clostridia E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k141_191_16 1408823.AXUS01000016_gene1037 5.69e-140 409.0 COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,25R7F@186804|Peptostreptococcaceae 186801|Clostridia E Psort location Cytoplasmic, score 8.87 dapL - 3.5.1.47 ko:K05823 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00525 R02733 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k141_191_17 1280692.AUJL01000013_gene3271 1.15e-11 72.0 COG1266@1|root,COG1266@2|Bacteria,1VAFM@1239|Firmicutes,24DNF@186801|Clostridia 186801|Clostridia S CAAX amino terminal protease family protein - - - ko:K07052 - - - - ko00000 - - - Abi k141_191_18 1301100.HG529385_gene5101 1.84e-93 281.0 COG0500@1|root,COG2226@2|Bacteria,1TQUF@1239|Firmicutes,25E3F@186801|Clostridia,36UHC@31979|Clostridiaceae 186801|Clostridia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k141_191_19 888064.HMPREF9088_1817 8.42e-29 104.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,4B3ES@81852|Enterococcaceae 91061|Bacilli K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k141_191_20 1511.CLOST_0638 7.86e-125 365.0 COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,25QSQ@186804|Peptostreptococcaceae 186801|Clostridia O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k141_191_21 240302.BN982_00115 4.57e-87 290.0 COG3290@1|root,COG3829@1|root,COG3290@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,3NE2G@45667|Halobacillus 91061|Bacilli KT Bacterial regulatory protein, Fis family bkdR - - - - - - - - - - - DapB_N,HTH_8,PAS,Sigma54_activat k141_191_22 1121324.CLIT_23c01630 6.56e-230 640.0 COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,25QSK@186804|Peptostreptococcaceae 186801|Clostridia E Cys/Met metabolism PLP-dependent enzyme megL - 2.5.1.48,4.4.1.11 ko:K01739,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k141_191_23 1321779.HMPREF1984_00459 9.24e-216 619.0 COG0737@1|root,COG0737@2|Bacteria,3795N@32066|Fusobacteria 32066|Fusobacteria F Belongs to the 5'-nucleotidase family - - 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 - R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k141_191_24 1476973.JMMB01000007_gene3067 1.69e-133 399.0 COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,25R2W@186804|Peptostreptococcaceae 186801|Clostridia K RNA polymerase rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k141_191_25 1511.CLOST_0641 4.81e-115 344.0 COG2390@1|root,COG2390@2|Bacteria,1TP62@1239|Firmicutes,24B2X@186801|Clostridia,25SNA@186804|Peptostreptococcaceae 186801|Clostridia K Putative sugar-binding domain cggR - - ko:K05311 - - - - ko00000,ko03000 - - - Sugar-bind k141_191_26 1304284.L21TH_1220 3.86e-177 501.0 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,36DD0@31979|Clostridiaceae 186801|Clostridia G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k141_191_27 929506.CbC4_0572 2.24e-232 646.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,36ETN@31979|Clostridiaceae 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k141_191_28 1151292.QEW_3795 1.84e-131 378.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,25QK7@186804|Peptostreptococcaceae 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS19265 TIM k141_191_29 1031288.AXAA01000021_gene2426 1.38e-250 701.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,36EXB@31979|Clostridiaceae 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k141_191_30 1121289.JHVL01000018_gene624 1.91e-240 669.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,36ET7@31979|Clostridiaceae 186801|Clostridia G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k141_191_31 1286171.EAL2_c15780 3.8e-26 98.2 COG1314@1|root,COG1314@2|Bacteria,1UA33@1239|Firmicutes,25N7X@186801|Clostridia,25XP1@186806|Eubacteriaceae 186801|Clostridia U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k141_191_32 1408422.JHYF01000004_gene1470 0.0 996.0 COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae 186801|Clostridia C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k141_191_33 517418.Ctha_0021 1.03e-74 264.0 COG2202@1|root,COG2203@1|root,COG3887@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3887@2|Bacteria,COG4251@2|Bacteria,1FFEN@1090|Chlorobi 1090|Chlorobi T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,PAS_9 k141_191_34 306281.AJLK01000029_gene2192 3.32e-32 118.0 COG0784@1|root,COG0784@2|Bacteria,1G63B@1117|Cyanobacteria,1JJBB@1189|Stigonemataceae 1117|Cyanobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k141_191_35 1408823.AXUS01000016_gene1063 7.24e-296 833.0 COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,25QS9@186804|Peptostreptococcaceae 186801|Clostridia J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k141_191_36 500633.CLOHIR_00852 1.99e-73 223.0 COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,25RAS@186804|Peptostreptococcaceae 186801|Clostridia O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k141_191_37 572546.Arcpr_1769 6.98e-34 123.0 arCOG13036@1|root,arCOG13036@2157|Archaea,2Y25M@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - k141_191_38 720554.Clocl_0183 1.84e-66 217.0 2BU13@1|root,32P9R@2|Bacteria,1V8XK@1239|Firmicutes,24M09@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_191_39 720554.Clocl_0184 4.21e-115 345.0 COG3344@1|root,COG3344@2|Bacteria,1UZGS@1239|Firmicutes,247Z6@186801|Clostridia,3WIXG@541000|Ruminococcaceae 186801|Clostridia L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k141_224_1 635013.TherJR_2632 9.41e-84 268.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae 186801|Clostridia V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k141_224_2 1007096.BAGW01000013_gene2540 1.14e-84 258.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,2N6MS@216572|Oscillospiraceae 186801|Clostridia V ATPases associated with a variety of cellular activities macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_224_3 515635.Dtur_0739 8.72e-19 96.3 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k141_224_4 997350.HMPREF9129_1263 2.89e-191 554.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,22GNM@1570339|Peptoniphilaceae 186801|Clostridia H Thiamine pyrophosphate enzyme, N-terminal TPP binding domain ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k141_224_5 1511.CLOST_1422 6.61e-241 680.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,25SKM@186804|Peptostreptococcaceae 186801|Clostridia H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k141_224_6 1128398.Curi_c12340 1e-162 464.0 COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,267TH@186813|unclassified Clostridiales 186801|Clostridia EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10005,iHN637.CLJU_RS10010 IlvC,IlvN k141_224_8 1121324.CLIT_13c00520 2.68e-193 553.0 COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia 186801|Clostridia E Orn Lys Arg decarboxylase major speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C k141_224_9 1511.CLOST_0043 7.38e-70 213.0 COG1586@1|root,COG1586@2|Bacteria,1V3U2@1239|Firmicutes,24H9Q@186801|Clostridia 186801|Clostridia E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10460 AdoMet_dc k141_224_10 1304284.L21TH_0235 1.31e-149 427.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,36FAN@31979|Clostridiaceae 186801|Clostridia E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k141_224_11 1511.CLOST_0041 2.93e-146 418.0 COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia 186801|Clostridia E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k141_224_13 1499967.BAYZ01000174_gene5832 1.26e-16 90.5 COG3437@1|root,COG4191@1|root,COG5000@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 ko:K01768,ko:K02488,ko:K17763 ko00230,ko02020,ko02025,ko04112,ko04113,ko04213,map00230,map02020,map02025,map04112,map04113,map04213 M00511,M00695 R00089,R00434,R08057 RC00295 ko00000,ko00001,ko00002,ko01000,ko02022,ko03021 - - - GGDEF,HAMP,HATPase_c,HisKA,HisKA_3,PAS,PAS_4,PAS_9,Response_reg k141_224_14 589873.EP13_00325 8.45e-31 139.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4664E@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF EAL domain-containing protein - - - - - - - - - - - - EAL,GGDEF,dCache_3 k141_224_15 373994.Riv7116_5551 8.04e-20 94.7 COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1G4YP@1117|Cyanobacteria,1HR78@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k141_224_16 1031288.AXAA01000004_gene1827 5.5e-58 185.0 COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,36IPU@31979|Clostridiaceae 186801|Clostridia C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k141_224_17 903814.ELI_0845 1.81e-30 113.0 COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,25X30@186806|Eubacteriaceae 186801|Clostridia C Ferredoxin - - 1.12.1.3 ko:K17992 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx k141_224_18 1280390.CBQR020000146_gene3731 2.03e-270 759.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,4I6ZB@91061|Bacilli,26VMP@186822|Paenibacillaceae 91061|Bacilli C NADH dehydrogenase - - 1.12.1.3 ko:K18331 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k141_224_19 350688.Clos_0930 8.25e-259 728.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,36DJB@31979|Clostridiaceae 186801|Clostridia C iron hydrogenase, small subunit - - 1.12.1.3,1.6.5.3 ko:K00336,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3 k141_224_20 1540257.JQMW01000013_gene1167 6.57e-58 185.0 2BREV@1|root,32KDP@2|Bacteria,1V8FF@1239|Firmicutes,25AY9@186801|Clostridia,36W6C@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF2975) - - - - - - - - - - - - DUF2975 k141_224_21 1499689.CCNN01000007_gene914 1.29e-30 109.0 COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,36KI4@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 k141_192_2 445970.ALIPUT_00204 5.43e-94 284.0 COG3391@1|root,COG3391@2|Bacteria,4NESV@976|Bacteroidetes,2FQ4W@200643|Bacteroidia,22UWJ@171550|Rikenellaceae 976|Bacteroidetes S COG NOG25284 non supervised orthologous group - - - - - - - - - - - - - k141_120_2 1286171.EAL2_c01440 1.12e-83 251.0 COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,25VW0@186806|Eubacteriaceae 186801|Clostridia K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k141_120_3 478749.BRYFOR_08055 4.93e-75 226.0 COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k141_120_4 1408823.AXUS01000015_gene1424 7.92e-129 370.0 COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,25QD0@186804|Peptostreptococcaceae 186801|Clostridia J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k141_120_5 1121324.CLIT_24c00770 3.67e-73 224.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k141_120_6 1356854.N007_07710 7.82e-49 159.0 COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,4HIGQ@91061|Bacilli,279YN@186823|Alicyclobacillaceae 91061|Bacilli J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k141_120_7 1301100.HG529434_gene6530 0.0 1959.0 COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,36EKQ@31979|Clostridiaceae 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k141_120_8 1219626.HMPREF1639_02175 0.0 1833.0 COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,25QQ9@186804|Peptostreptococcaceae 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k141_120_9 536232.CLM_3954 1.69e-20 84.3 COG1358@1|root,COG1358@2|Bacteria,1VFD8@1239|Firmicutes,24R27@186801|Clostridia,36MMW@31979|Clostridiaceae 186801|Clostridia J ribosomal protein - - - ko:K07590 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L7Ae k141_120_10 1121324.CLIT_24c00720 2.19e-79 237.0 COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia 186801|Clostridia J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k141_120_11 1121289.JHVL01000060_gene2529 5.7e-83 248.0 COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,36DC5@31979|Clostridiaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k141_120_12 1121324.CLIT_24c00700 0.0 1160.0 COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,25QN5@186804|Peptostreptococcaceae 186801|Clostridia J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k141_225_2 1230342.CTM_25848 8.71e-71 233.0 COG3677@1|root,COG3677@2|Bacteria,1TQNY@1239|Firmicutes,249FY@186801|Clostridia,36EGV@31979|Clostridiaceae 186801|Clostridia L Tn7-like transposition protein D - - - - - - - - - - - - TniQ,TnsD k141_225_4 1117108.PAALTS15_05858 0.0 2261.0 COG5635@1|root,COG5635@2|Bacteria,1UK9Y@1239|Firmicutes 1239|Firmicutes T Nacht domain - - - - - - - - - - - - NACHT k141_225_6 641107.CDLVIII_5907 5.08e-62 203.0 COG2176@1|root,COG2176@2|Bacteria,1VAGI@1239|Firmicutes,24N73@186801|Clostridia,36M5M@31979|Clostridiaceae 186801|Clostridia L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k141_208_127 1121289.JHVL01000007_gene2729 1.65e-149 422.0 29P90@1|root,30A74@2|Bacteria,1V5NA@1239|Firmicutes,24WQ2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_208_128 1121289.JHVL01000007_gene2728 8.04e-199 552.0 COG2856@1|root,COG2856@2|Bacteria,1V013@1239|Firmicutes,24CWK@186801|Clostridia,36Q22@31979|Clostridiaceae 186801|Clostridia E IrrE N-terminal-like domain - - - - - - - - - - - - Peptidase_M78 k141_208_129 1121289.JHVL01000007_gene2727 4.81e-72 217.0 COG3620@1|root,COG3620@2|Bacteria,1VE10@1239|Firmicutes,24MPW@186801|Clostridia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k141_208_131 457396.CSBG_01431 2.85e-16 84.7 COG0551@1|root,COG0551@2|Bacteria,1V93W@1239|Firmicutes,24CEN@186801|Clostridia,36IXA@31979|Clostridiaceae 186801|Clostridia L NERD domain protein - - - - - - - - - - - - NERD,zf-C4_Topoisom k141_208_132 1209989.TepiRe1_2570 4.32e-21 86.7 COG2002@1|root,COG2002@2|Bacteria,1V8G8@1239|Firmicutes,24JVE@186801|Clostridia,42IPR@68295|Thermoanaerobacterales 186801|Clostridia K SpoVT / AbrB like domain - - - - - - - - - - - - - k141_208_137 1345695.CLSA_c39400 2.16e-24 115.0 COG0699@1|root,COG0699@2|Bacteria,1U979@1239|Firmicutes,24UQD@186801|Clostridia 186801|Clostridia S Dynamin family - - - - - - - - - - - - Dynamin_N k141_208_139 273068.TTE0668 3.39e-232 664.0 COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,42EJW@68295|Thermoanaerobacterales 186801|Clostridia GM PFAM Polysaccharide biosynthesis protein capD - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 k141_208_140 1508644.SFBmNL_00136 4.32e-115 341.0 COG5635@1|root,COG5635@2|Bacteria,1VPBQ@1239|Firmicutes,24VAQ@186801|Clostridia 186801|Clostridia T Nacht domain - - - - - - - - - - - - - k141_208_141 1508644.SFBmNL_00137 1.4e-26 99.8 2EGFA@1|root,33A7A@2|Bacteria,1VQNH@1239|Firmicutes,24V7U@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_208_142 1508644.SFBmNL_01536 3.84e-190 553.0 COG5293@1|root,COG5293@2|Bacteria,1V11B@1239|Firmicutes,24FB1@186801|Clostridia 186801|Clostridia S Uncharacterised protein conserved in bacteria (DUF2326) - - - - - - - - - - - - DUF2326 k141_208_145 1209989.TepiRe1_2683 1.59e-28 133.0 28IXE@1|root,2Z8VB@2|Bacteria,1U464@1239|Firmicutes,24BH6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_208_146 1121289.JHVL01000001_gene1881 1.05e-251 808.0 COG3391@1|root,COG4733@1|root,COG3391@2|Bacteria,COG4733@2|Bacteria,1TT7S@1239|Firmicutes,24EIJ@186801|Clostridia,36GQ1@31979|Clostridiaceae 186801|Clostridia S ig-like, plexins, transcription factors - - - - - - - - - - - - TIG,fn3 k141_193_1 1321778.HMPREF1982_01131 1.22e-113 335.0 COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,248MW@186801|Clostridia,26CPG@186813|unclassified Clostridiales 186801|Clostridia S Sucrose-6F-phosphate phosphohydrolase - - - - - - - - - - - - Hydrolase_3 k141_193_7 457396.CSBG_00859 4.29e-81 260.0 COG0477@1|root,COG0477@2|Bacteria,1V5JX@1239|Firmicutes,25FX2@186801|Clostridia,36U62@31979|Clostridiaceae 186801|Clostridia EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k141_193_9 1121324.CLIT_11c00110 6.09e-142 412.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,25RQQ@186804|Peptostreptococcaceae 186801|Clostridia EJ Asparaginase ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k141_193_11 1301100.HG529270_gene557 9.41e-50 178.0 COG0526@1|root,COG0526@2|Bacteria,1UY9A@1239|Firmicutes,24C03@186801|Clostridia,36KUB@31979|Clostridiaceae 186801|Clostridia CO Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin k141_193_12 1121289.JHVL01000012_gene1695 3.18e-104 337.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,36EQ4@31979|Clostridiaceae 186801|Clostridia V ABC transporter permease - - - ko:K02004,ko:K11632 ko02010,ko02020,map02010,map02020 M00258,M00314,M00737,M00738 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.134.3 - - FtsX k141_193_13 1321778.HMPREF1982_01633 7.21e-116 339.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,267ME@186813|unclassified Clostridiales 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02003,ko:K11635 ko02020,map02020 M00258,M00315 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.134.6 - - ABC_tran k141_240_70 1121289.JHVL01000005_gene1026 1.61e-67 234.0 COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,247YE@186801|Clostridia 186801|Clostridia T Signal transduction histidine kinase regulating citrate malate metabolism - - 2.7.13.3 ko:K07700 ko02020,map02020 M00486 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,SPOB_a k141_240_71 387092.NIS_0518 6.56e-62 225.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_3,PAS_4,PAS_9 k141_240_72 1321778.HMPREF1982_00530 5.34e-52 176.0 COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia,26A4G@186813|unclassified Clostridiales 186801|Clostridia I Phosphate acyltransferases plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k141_240_73 931276.Cspa_c38590 2.21e-37 140.0 COG0561@1|root,COG0561@2|Bacteria,1U3W2@1239|Firmicutes,2486H@186801|Clostridia,36DQB@31979|Clostridiaceae 186801|Clostridia S hydrolase - - - - - - - - - - - - Hydrolase_3 k141_240_75 1443125.Z962_10495 4.3e-175 503.0 COG2056@1|root,COG2056@2|Bacteria,1TSRY@1239|Firmicutes,24A6E@186801|Clostridia,36FY0@31979|Clostridiaceae 186801|Clostridia S Na+-H+ antiporter family - - - ko:K07084 - - - - ko00000,ko02000 2.A.8.1.12 - - Na_H_antiport_2,Na_H_antiporter k141_240_76 1347392.CCEZ01000018_gene1082 1.81e-257 719.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,36DCC@31979|Clostridiaceae 186801|Clostridia E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k141_240_77 1321778.HMPREF1982_01119 2.1e-165 472.0 COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,267IZ@186813|unclassified Clostridiales 186801|Clostridia J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k141_240_79 864565.HMPREF0379_2003 1.48e-07 50.8 COG0425@1|root,COG0425@2|Bacteria 2|Bacteria O sulfur carrier activity - - - - - - - - - - - - DrsE,TusA k141_240_80 318464.IO99_02240 2.13e-165 473.0 COG2391@1|root,COG2391@2|Bacteria,1TPWG@1239|Firmicutes,249KU@186801|Clostridia,36GD5@31979|Clostridiaceae 186801|Clostridia S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k141_240_82 545243.BAEV01000086_gene2332 1.92e-69 237.0 COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,36DPA@31979|Clostridiaceae 186801|Clostridia J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 k141_240_83 857293.CAAU_0679 1.27e-141 431.0 COG0840@1|root,COG0840@2|Bacteria,1TSP5@1239|Firmicutes,24AUD@186801|Clostridia,36EC7@31979|Clostridiaceae 186801|Clostridia NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HNOB,MCPsignal k141_240_84 865861.AZSU01000009_gene575 3.35e-172 498.0 COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,36DX8@31979|Clostridiaceae 186801|Clostridia E Dipeptidase - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k141_240_86 865861.AZSU01000002_gene2572 2.14e-27 103.0 2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,36UF4@31979|Clostridiaceae 186801|Clostridia S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD k141_240_87 1304284.L21TH_1909 0.0 886.0 COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,36DEB@31979|Clostridiaceae 186801|Clostridia S oligopeptide transporter, OPT family - - - - - - - - - - - - OPT k141_240_88 1121289.JHVL01000029_gene446 5.45e-84 259.0 COG1291@1|root,COG1291@2|Bacteria,1VUY7@1239|Firmicutes,25DI1@186801|Clostridia,36UBH@31979|Clostridiaceae 186801|Clostridia N MotA/TolQ/ExbB proton channel family - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k141_240_89 293826.Amet_0297 3.36e-62 201.0 COG1360@1|root,COG1360@2|Bacteria,1UXY4@1239|Firmicutes,247RE@186801|Clostridia,36DJJ@31979|Clostridiaceae 186801|Clostridia N PFAM OmpA MotB domain protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k141_240_90 517418.Ctha_1418 7.84e-190 538.0 COG0426@1|root,COG0426@2|Bacteria,1FDX4@1090|Chlorobi 1090|Chlorobi C PFAM beta-lactamase domain protein - - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B k141_240_91 1121289.JHVL01000004_gene2101 6.67e-27 106.0 COG1633@1|root,COG1633@2|Bacteria,1UG7M@1239|Firmicutes,25NGE@186801|Clostridia,36T0K@31979|Clostridiaceae 186801|Clostridia S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k141_240_92 293826.Amet_4301 9.61e-250 701.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,36EVZ@31979|Clostridiaceae 186801|Clostridia T carbon starvation protein CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k141_240_93 293826.Amet_1379 3.13e-27 107.0 2C1YE@1|root,330PN@2|Bacteria,1VHRZ@1239|Firmicutes,24M1A@186801|Clostridia,36NF5@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_240_94 1286171.EAL2_c14950 6.16e-95 289.0 COG0583@1|root,COG0583@2|Bacteria,1TSA6@1239|Firmicutes,24BM8@186801|Clostridia,25X2I@186806|Eubacteriaceae 186801|Clostridia K LysR substrate binding domain cmpR - - - - - - - - - - - HTH_1,LysR_substrate k141_240_95 1121324.CLIT_14c00220 6.78e-43 159.0 COG3437@1|root,COG3437@2|Bacteria,1V6Y5@1239|Firmicutes,24DN3@186801|Clostridia 186801|Clostridia T PFAM response regulator receiver - - - - - - - - - - - - Response_reg k141_240_96 1286632.P278_06200 3.3e-11 68.2 COG0745@1|root,COG0745@2|Bacteria,4NQNT@976|Bacteroidetes,1I3AQ@117743|Flavobacteriia 976|Bacteroidetes T Response regulator receiver domain - - - - - - - - - - - - Response_reg k141_240_97 580331.Thit_1844 1.9e-101 335.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1V2NQ@1239|Firmicutes,25KP2@186801|Clostridia,42I7M@68295|Thermoanaerobacterales 186801|Clostridia T PFAM ATP-binding region, ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA k141_240_98 880070.Cycma_3683 3.91e-56 213.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes 976|Bacteroidetes T Histidine kinase - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg k141_240_99 350688.Clos_0228 1.94e-84 259.0 COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,36DDY@31979|Clostridiaceae 186801|Clostridia O peptidylprolyl isomerase prsA2 - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k141_240_100 1235796.C815_01766 1.75e-72 243.0 COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes 1239|Firmicutes F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iSB619.SA_RS05225 GATase_6,GATase_7,Pribosyltran k141_240_101 866895.HBHAL_3422 2.02e-09 62.8 COG0352@1|root,COG0352@2|Bacteria,1V6KJ@1239|Firmicutes,4HIM9@91061|Bacilli,3NFHV@45667|Halobacillus 91061|Bacilli H Thiamine monophosphate synthase tenI GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,5.3.99.10 ko:K00788,ko:K10810 ko00730,ko01100,map00730,map01100 M00127 R03223,R09977,R10712 RC00224,RC02766,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000,ko03000 - - - TMP-TENI k141_240_102 1487921.DP68_10660 2.51e-251 697.0 COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,36EE1@31979|Clostridiaceae 186801|Clostridia H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k141_240_103 1304880.JAGB01000002_gene1796 2.02e-145 423.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia 186801|Clostridia C biosynthesis protein ThiH thiH - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k141_240_104 1121324.CLIT_23c00110 9.82e-122 354.0 COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,247TJ@186801|Clostridia,25QFQ@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k141_240_105 445973.CLOBAR_01599 7.89e-79 246.0 COG0476@1|root,COG0476@2|Bacteria,1UYFC@1239|Firmicutes,247UZ@186801|Clostridia,25RW4@186804|Peptostreptococcaceae 186801|Clostridia H Thiamine biosynthesis protein ThiF thiF - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF,ThiS-like k141_240_106 272562.CA_C2924 3.59e-12 62.0 COG2104@1|root,COG2104@2|Bacteria,1VKB4@1239|Firmicutes,25MYF@186801|Clostridia,36PCS@31979|Clostridiaceae 186801|Clostridia H ThiS family - - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k141_240_107 251229.Chro_5503 4.53e-58 231.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG5001@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG5001@2|Bacteria,1GIUR@1117|Cyanobacteria,3VIDX@52604|Pleurocapsales 1117|Cyanobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,GGDEF,Pkinase k141_240_109 1121324.CLIT_2c03740 1.12e-146 431.0 COG3858@1|root,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia 186801|Clostridia M family 18 ydhD - - - - - - - - - - - CW_binding_2,Cu_amine_oxidN1,Glyco_hydro_18,SH3_3 k141_240_110 333138.LQ50_12555 9.52e-192 542.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,1ZB7V@1386|Bacillus 91061|Bacilli I Belongs to the thiolase family atoB GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iYO844.BSU24170 Thiolase_C,Thiolase_N k141_240_112 580331.Thit_1797 1.31e-142 430.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,42F02@68295|Thermoanaerobacterales 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - FeS,Fe_hyd_lg_C,HTH_8,PAS,PAS_9,PTS-HPr,Sigma54_activat k141_240_113 997296.PB1_02105 1.67e-211 607.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,4H9VD@91061|Bacilli,1ZAU2@1386|Bacillus 91061|Bacilli G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k141_240_114 1226325.HMPREF1548_02317 3.7e-17 76.3 COG1925@1|root,COG1925@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system fryA - 2.7.3.9 ko:K08483,ko:K11184,ko:K11189,ko:K11201 ko02060,map02060 M00306 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 k141_240_115 1444309.JAQG01000116_gene3093 8.06e-139 412.0 COG3876@1|root,COG3876@2|Bacteria 2|Bacteria G Protein conserved in bacteria ybbC - - - - - - - - - - - Cu_amine_oxidN1,DUF1343,Polysacc_deac_1 k141_240_116 1499684.CCNP01000018_gene1543 1.1e-122 363.0 COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,36F0J@31979|Clostridiaceae 186801|Clostridia D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k141_243_392 1121324.CLIT_23c02900 5.86e-166 479.0 COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia 186801|Clostridia F permease uraA - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease k141_243_393 1391646.AVSU01000001_gene223 6.9e-99 291.0 COG3172@1|root,COG3172@2|Bacteria,1VR87@1239|Firmicutes,25DYE@186801|Clostridia 186801|Clostridia H AAA domain - - - - - - - - - - - - AAA_28 k141_243_394 1391646.AVSU01000054_gene1156 1.73e-207 599.0 COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,25QWG@186804|Peptostreptococcaceae 186801|Clostridia K Psort location Cytoplasmic, score FbpA - - - - - - - - - - - DUF814,FbpA k141_243_395 445973.CLOBAR_01452 1.75e-108 323.0 COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,25QT7@186804|Peptostreptococcaceae 186801|Clostridia S Domain of unknown function (DUF1732) yicC - - - - - - - - - - - DUF1732,YicC_N k141_243_396 1286171.EAL2_c14790 6.77e-40 134.0 COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia,25X81@186806|Eubacteriaceae 186801|Clostridia S Domain of unknown function (DUF370) NPD7_560 - - ko:K09777 - - - - ko00000 - - - DUF370 k141_243_397 318464.IO99_09705 1.08e-73 228.0 COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae 186801|Clostridia F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k141_243_398 1408422.JHYF01000002_gene2593 2.79e-12 63.2 COG1758@1|root,COG1758@2|Bacteria,1VK74@1239|Firmicutes,24QQK@186801|Clostridia,36MND@31979|Clostridiaceae 186801|Clostridia K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k141_243_399 272563.CD630_25870 2.64e-185 526.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25QR8@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k141_243_400 1301100.HG529232_gene7464 1.83e-266 766.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,36DH7@31979|Clostridiaceae 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k141_243_401 272563.CD630_25850 5.13e-69 212.0 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,25RD5@186804|Peptostreptococcaceae 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k141_243_402 545243.BAEV01000106_gene2749 1.86e-99 301.0 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,36EJW@31979|Clostridiaceae 186801|Clostridia J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k141_243_403 1304284.L21TH_0669 3.98e-60 197.0 COG1852@1|root,COG1852@2|Bacteria,1V1B5@1239|Firmicutes,24G2F@186801|Clostridia,36K8X@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF116 - - - ko:K09729 - - - - ko00000 - - - DUF116 k141_243_404 1151292.QEW_3126 6.22e-165 478.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,25QCI@186804|Peptostreptococcaceae 186801|Clostridia J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k141_243_405 1286171.EAL2_c14690 8.69e-146 422.0 COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,25UW3@186806|Eubacteriaceae 186801|Clostridia J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k141_243_406 858215.Thexy_1387 5.52e-47 163.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,42EM8@68295|Thermoanaerobacterales 186801|Clostridia T protein phosphatase 2C domain protein stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k141_243_407 1511.CLOST_1849 1.27e-136 422.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,25QJS@186804|Peptostreptococcaceae 186801|Clostridia KLT Psort location CytoplasmicMembrane, score prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k141_243_408 1121324.CLIT_23c03080 1.22e-127 372.0 COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,25QPZ@186804|Peptostreptococcaceae 186801|Clostridia S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N k141_243_409 1292035.H476_2037 1.23e-114 333.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,25R34@186804|Peptostreptococcaceae 186801|Clostridia G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k141_243_410 509191.AEDB02000108_gene1673 1.08e-40 145.0 COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,3WJUT@541000|Ruminococcaceae 186801|Clostridia H thiamine pyrophosphokinase thiN - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic k141_243_411 696747.NIES39_A04120 1.51e-104 310.0 COG1180@1|root,COG1180@2|Bacteria,1G268@1117|Cyanobacteria,1H7HG@1150|Oscillatoriales 1117|Cyanobacteria C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k141_243_412 500633.CLOHIR_01853 0.0 1111.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,25R2X@186804|Peptostreptococcaceae 186801|Clostridia C Psort location Cytoplasmic, score pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k141_243_413 1121324.CLIT_10c03950 4.05e-104 313.0 COG0491@1|root,COG0491@2|Bacteria,1TT3D@1239|Firmicutes,24BV1@186801|Clostridia,25QQM@186804|Peptostreptococcaceae 186801|Clostridia S Metallo-beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k141_243_414 1121324.CLIT_10c03940 1.64e-129 374.0 COG2357@1|root,COG2357@2|Bacteria,1TQ2F@1239|Firmicutes,249FE@186801|Clostridia,25QGC@186804|Peptostreptococcaceae 186801|Clostridia S RelA SpoT domain protein yjbM - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT k141_243_415 1216362.B437_04165 5.96e-33 127.0 COG0037@1|root,COG0037@2|Bacteria,378FH@32066|Fusobacteria 32066|Fusobacteria H Belongs to the TtcA family - - - - - - - - - - - - ATP_bind_3 k141_243_416 1292035.H476_0342 1.71e-111 326.0 COG1768@1|root,COG1768@2|Bacteria,1V3XB@1239|Firmicutes,249BN@186801|Clostridia,25R0P@186804|Peptostreptococcaceae 186801|Clostridia S Ser Thr phosphatase family protein - - - ko:K07099 - - - - ko00000 - - - Metallophos k141_243_417 1345695.CLSA_c19650 1.87e-74 259.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_243_418 445970.ALIPUT_02060 2.52e-06 53.5 COG1787@1|root,COG1787@2|Bacteria,4NNG6@976|Bacteroidetes,2FSFZ@200643|Bacteroidia 976|Bacteroidetes L Restriction endonuclease - - - ko:K07448 - - - - ko00000,ko02048 - - - Mrr_cat k141_243_419 1151292.QEW_0523 1e-154 448.0 COG0500@1|root,COG0500@2|Bacteria,1UHX5@1239|Firmicutes,25E63@186801|Clostridia,25UPV@186804|Peptostreptococcaceae 186801|Clostridia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_32 k141_243_421 1262915.BN574_01019 3.96e-27 99.8 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes 1239|Firmicutes J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k141_243_422 445971.ANASTE_02003 1.56e-30 112.0 COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes,24JIA@186801|Clostridia,25WQ4@186806|Eubacteriaceae 186801|Clostridia S Asp23 family, cell envelope-related function - - - - - - - - - - - - Asp23 k141_243_423 272563.CD630_25610 6.6e-206 590.0 COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,25QKG@186804|Peptostreptococcaceae 186801|Clostridia S DAK2 domain fusion protein YloV yloV - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 k141_243_424 1443122.Z958_03090 1.72e-194 562.0 COG3275@1|root,COG3275@2|Bacteria,1VTXF@1239|Firmicutes,25E5Z@186801|Clostridia,36E2G@31979|Clostridiaceae 186801|Clostridia T Histidine kinase ypdA - 2.7.13.3 ko:K02478,ko:K07704 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 5TM-5TMR_LYT,GAF_3,HATPase_c,His_kinase k141_243_425 318464.IO99_04295 3.87e-86 263.0 COG3279@1|root,COG3279@2|Bacteria,1V14X@1239|Firmicutes,24BG9@186801|Clostridia,36E97@31979|Clostridiaceae 186801|Clostridia KT response regulator ypdB - - ko:K02477,ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k141_243_426 1121324.CLIT_23c00780 2.12e-247 690.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,25QTF@186804|Peptostreptococcaceae 186801|Clostridia T Carbon starvation protein CstA cstA - - - - - - - - - - - CstA,CstA_5TM k141_243_427 1499689.CCNN01000009_gene2866 1.39e-152 441.0 COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia,36DIQ@31979|Clostridiaceae 186801|Clostridia C radical SAM domain protein hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k141_243_428 545243.BAEV01000006_gene1309 4.99e-30 108.0 COG0864@1|root,COG0864@2|Bacteria,1VF9M@1239|Firmicutes,24QVJ@186801|Clostridia,36N04@31979|Clostridiaceae 186801|Clostridia K Iron-only hydrogenase system regulator - - - - - - - - - - - - NikR_C k141_243_429 1286171.EAL2_c04210 5.54e-228 640.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,25V8I@186806|Eubacteriaceae 186801|Clostridia C Biotin and Thiamin Synthesis associated domain hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM k141_243_430 226185.EF_2470 3.62e-36 130.0 COG1078@1|root,COG1078@2|Bacteria,1UHY1@1239|Firmicutes,4ISAF@91061|Bacilli,4B0RZ@81852|Enterococcaceae 91061|Bacilli S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD k141_243_431 441769.ABFU01000010_gene2611 4.28e-108 340.0 COG3227@1|root,COG3227@2|Bacteria,1TP08@1239|Firmicutes,4H9S6@91061|Bacilli,1ZCEP@1386|Bacillus 91061|Bacilli E Peptidase M4 nprE GO:0005575,GO:0005576 3.4.24.28 ko:K01400 - - - - ko00000,ko01000,ko01002 - - - FTP,PPC,PepSY,Peptidase_M4,Peptidase_M4_C k141_243_432 1385510.N781_17160 4.93e-128 392.0 COG3227@1|root,COG3227@2|Bacteria,1TP08@1239|Firmicutes,4H9S6@91061|Bacilli,2Y9Y7@289201|Pontibacillus 91061|Bacilli E Peptidase M4 - - 3.4.24.28 ko:K01400 - - - - ko00000,ko01000,ko01002 - - - FTP,PPC,PepSY,Peptidase_M4,Peptidase_M4_C k141_243_433 1229783.C273_09367 1.48e-35 133.0 COG3279@1|root,COG3279@2|Bacteria,1V392@1239|Firmicutes,4HHAI@91061|Bacilli,4GY5G@90964|Staphylococcaceae 91061|Bacilli K Regulator agrA - - ko:K07707 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k141_243_434 572544.Ilyop_0561 1.47e-223 630.0 COG1115@1|root,COG1115@2|Bacteria,3795Z@32066|Fusobacteria 32066|Fusobacteria E Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k141_243_435 500633.CLOHIR_01796 6.85e-89 275.0 COG1600@1|root,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,248M5@186801|Clostridia,25R2C@186804|Peptostreptococcaceae 186801|Clostridia C Domain of unknown function (DUF1730) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16,HEAT_2 k141_243_436 1499684.CCNP01000023_gene3394 3.89e-78 240.0 COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,36DBQ@31979|Clostridiaceae 186801|Clostridia L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k141_243_437 1151292.QEW_1840 8.94e-75 249.0 COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,25QWE@186804|Peptostreptococcaceae 186801|Clostridia V G5 - - - ko:K18346 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01504 - - - G5,PG_binding_4,VanW k141_243_438 1121324.CLIT_10c02760 1.31e-75 236.0 COG1655@1|root,COG1655@2|Bacteria,1UY0V@1239|Firmicutes,247VR@186801|Clostridia 186801|Clostridia K protein conserved in bacteria - - - ko:K09766 - - - - ko00000 - - - DUF2225,cNMP_binding k141_243_439 1151292.QEW_4060 2.01e-70 218.0 COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,25RRM@186804|Peptostreptococcaceae 186801|Clostridia H Cobinamide kinase / cobinamide phosphate guanyltransferase cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU k141_243_440 1511.CLOST_1102 4.05e-65 210.0 COG0368@1|root,COG0368@2|Bacteria,1V1QB@1239|Firmicutes,24I0D@186801|Clostridia,25QDZ@186804|Peptostreptococcaceae 186801|Clostridia H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k141_243_441 1408473.JHXO01000009_gene3311 7.35e-05 50.1 COG0406@1|root,COG0406@2|Bacteria,4NPZ0@976|Bacteroidetes,2FPTF@200643|Bacteroidia 976|Bacteroidetes G Belongs to the phosphoglycerate mutase family - - 5.4.2.12 ko:K15634,ko:K15640 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k141_243_442 1033737.CAEV01000048_gene1319 1.33e-50 175.0 COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,25AZZ@186801|Clostridia,36WB6@31979|Clostridiaceae 186801|Clostridia S hydrolase - - - - - - - - - - - - Hydrolase_3 k141_243_443 1304284.L21TH_2409 7.97e-88 277.0 COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,36GCZ@31979|Clostridiaceae 186801|Clostridia C Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362,Fer4,Fer4_10,Fer4_7 k141_243_444 536232.CLM_0267 2.02e-53 173.0 COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,36I1E@31979|Clostridiaceae 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k141_128_23 545697.HMPREF0216_02161 5.3e-66 209.0 COG0494@1|root,COG0494@2|Bacteria,1V6SF@1239|Firmicutes,24HCG@186801|Clostridia,36IWP@31979|Clostridiaceae 186801|Clostridia L pfam nudix - - - - - - - - - - - - NUDIX k141_128_24 1121324.CLIT_5c01400 3.36e-08 55.5 COG3339@1|root,COG3339@2|Bacteria,1VP28@1239|Firmicutes,24WC2@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k141_128_25 1232447.BAHW02000009_gene287 5.16e-70 230.0 COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,26B3K@186813|unclassified Clostridiales 186801|Clostridia E Aminotransferase class I and II hisC - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k141_128_26 1511.CLOST_1919 2.72e-73 224.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,25RGX@186804|Peptostreptococcaceae 186801|Clostridia F Phosphoribosyl transferase domain hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k141_128_27 1476973.JMMB01000007_gene810 8.71e-156 468.0 COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,24FPA@186801|Clostridia,25QW1@186804|Peptostreptococcaceae 186801|Clostridia T Stage II sporulation protein E - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_2,SpoIIE k141_128_28 1151292.QEW_3228 7.14e-58 187.0 COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24IAS@186801|Clostridia,25RCH@186804|Peptostreptococcaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k141_128_29 1511.CLOST_1915 2.47e-96 284.0 COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,25S2P@186804|Peptostreptococcaceae 186801|Clostridia Q Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate pduL - 2.3.1.8 ko:K15024 ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200 M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans,PTAC k141_128_30 1121324.CLIT_11c00240 1.38e-190 551.0 COG1227@1|root,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,25R22@186804|Peptostreptococcaceae 186801|Clostridia C DHHA2 ppaC - 3.6.1.1 ko:K15986 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - CBS,DHH,DHHA2,DRTGG k141_128_31 596315.HMPREF0634_1600 2.29e-180 512.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,25QWM@186804|Peptostreptococcaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k141_128_32 1476973.JMMB01000007_gene1186 1.76e-22 100.0 COG2508@1|root,COG2508@2|Bacteria,1UESS@1239|Firmicutes,25JS8@186801|Clostridia,25TC5@186804|Peptostreptococcaceae 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 k141_128_33 1380408.AVGH01000024_gene1641 3.86e-72 225.0 COG0637@1|root,COG0637@2|Bacteria,1UY8N@1239|Firmicutes,4HFF9@91061|Bacilli,21WUJ@150247|Anoxybacillus 91061|Bacilli S haloacid dehalogenase-like hydrolase pgmB - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 k141_128_34 1123300.AUIN01000017_gene698 3.21e-45 162.0 COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,4HA4J@91061|Bacilli 91061|Bacilli G Aldose 1-epimerase lacX - - - - - - - - - - - Aldose_epim k141_128_35 1274524.BSONL12_06428 7.19e-278 775.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,4HA1G@91061|Bacilli,1ZASC@1386|Bacillus 91061|Bacilli G COG0366 Glycosidases malL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C k141_128_36 441769.ABFU01000013_gene2518 0.0 1007.0 COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,4HAVB@91061|Bacilli,1ZBSM@1386|Bacillus 91061|Bacilli G Glycoside hydrolase, family 65 mapA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944 2.4.1.8 ko:K00691 ko00500,ko01100,map00500,map01100 - R01555 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k141_128_37 1035196.HMPREF9998_00380 1.83e-139 400.0 COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A48@186801|Clostridia,25S66@186804|Peptostreptococcaceae 186801|Clostridia P ABC transporter permease - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k141_128_38 1219626.HMPREF1639_08295 4.95e-154 439.0 COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,24ADV@186801|Clostridia,25R8S@186804|Peptostreptococcaceae 186801|Clostridia P ABC transporter permease - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k141_128_39 634956.Geoth_3123 7.49e-211 594.0 COG1653@1|root,COG1653@2|Bacteria,1TQHT@1239|Firmicutes,4HAH2@91061|Bacilli 91061|Bacilli G ABC transporter, substratebinding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8 k141_128_40 1031288.AXAA01000039_gene85 2.14e-90 281.0 COG1609@1|root,COG1609@2|Bacteria,1TPZM@1239|Firmicutes,248WQ@186801|Clostridia,36GJ7@31979|Clostridiaceae 186801|Clostridia K lacI family - - 5.1.1.1 ko:K01775,ko:K02529 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011,ko03000 - - - LacI,Peripla_BP_3 k141_128_41 1443125.Z962_04580 8.67e-163 474.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae 186801|Clostridia V Mate efflux family protein mepA_10 - - - - - - - - - - - MatE k141_128_42 562983.HMPREF0433_00984 1.63e-16 73.9 COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,4HKQ8@91061|Bacilli,3WF1F@539002|Bacillales incertae sedis 91061|Bacilli O NifU-like domain yutI - - - - - - - - - - - NifU k141_128_43 272563.CD630_34120 0.0 935.0 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,25QUX@186804|Peptostreptococcaceae 186801|Clostridia L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k141_128_44 1121324.CLIT_13c01680 0.0 1406.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,25QCP@186804|Peptostreptococcaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k141_128_46 272563.CD630_34100 4.29e-202 585.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,25R2J@186804|Peptostreptococcaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k141_128_47 272563.CD630_34090 2.49e-136 395.0 COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,25QP9@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k141_128_48 1304284.L21TH_2538 4.15e-58 185.0 COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,36IZJ@31979|Clostridiaceae 186801|Clostridia C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit nuoE - 1.12.1.3,1.17.1.11,1.6.5.3 ko:K00334,ko:K18330,ko:K22340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k141_128_49 428125.CLOLEP_03892 2.46e-177 520.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3WGG2@541000|Ruminococcaceae 186801|Clostridia C NADH ubiquinone oxidoreductase hymB - 1.12.1.3,1.17.1.11,1.6.5.3 ko:K00335,ko:K18331,ko:K22339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k141_128_50 1031288.AXAA01000016_gene987 4.67e-56 211.0 COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,36UKJ@31979|Clostridiaceae 186801|Clostridia C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.10,1.17.1.11,1.17.1.9 ko:K00123,ko:K05299,ko:K22341 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k141_128_52 1321814.HMPREF9089_00089 5.16e-18 98.6 COG4249@1|root,COG4249@2|Bacteria,1U39P@1239|Firmicutes,24AUW@186801|Clostridia 186801|Clostridia S Caspase domain protein - - - - - - - - - - - - Peptidase_C14,SLH k141_129_1 406818.XBJ1_3658 1.05e-38 138.0 COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,1RNSF@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively mtnN GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008652,GO:0008782,GO:0008930,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009987,GO:0016053,GO:0016787,GO:0016798,GO:0016799,GO:0017144,GO:0019284,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0042802,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3384,iSBO_1134.SBO_0148 PNP_UDP_1 k141_61_2 351627.Csac_2714 4.35e-49 180.0 COG3464@1|root,COG4584@1|root,COG3464@2|Bacteria,COG4584@2|Bacteria,1VE6P@1239|Firmicutes,24EJ6@186801|Clostridia 186801|Clostridia L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3 k141_61_3 1487923.DP73_03460 6.54e-62 194.0 COG3464@1|root,COG3464@2|Bacteria,1VNXH@1239|Firmicutes,24UY7@186801|Clostridia 186801|Clostridia L zinc-finger of transposase IS204/IS1001/IS1096/IS1165 - - - - - - - - - - - - zf-ISL3 k141_231_4 500633.CLOHIR_02119 1.83e-69 217.0 COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,25RGG@186804|Peptostreptococcaceae 186801|Clostridia O Belongs to the sulfur carrier protein TusA family yedF - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE,TusA k141_231_11 478749.BRYFOR_09714 1.23e-08 53.1 2DQM3@1|root,337J4@2|Bacteria,1VGN5@1239|Firmicutes,24QUF@186801|Clostridia 186801|Clostridia S Helix-turn-helix domain - - - - - - - - - - - - HTH_16 k141_231_16 1123009.AUID01000012_gene1640 4.58e-13 65.5 2DR4V@1|root,33A63@2|Bacteria,1VKGM@1239|Firmicutes,25NVB@186801|Clostridia,26C13@186813|unclassified Clostridiales 186801|Clostridia S Protein of unknown function (DUF3343) - - - - - - - - - - - - DUF3343 k141_231_17 1286171.EAL2_c22140 3.46e-27 100.0 COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,24QKA@186801|Clostridia,25X9G@186806|Eubacteriaceae 186801|Clostridia S Bacterial protein of unknown function (DUF951) - - - - - - - - - - - - DUF951 k141_231_23 345219.Bcoa_1827 3.15e-37 152.0 COG4842@1|root,COG5444@1|root,COG4842@2|Bacteria,COG5444@2|Bacteria,1UJJY@1239|Firmicutes,4IQ2G@91061|Bacilli,1ZRH3@1386|Bacillus 91061|Bacilli S LXG domain of WXG superfamily - - - ko:K21493 - - - - ko00000,ko01000,ko02048 - - - LXG k141_231_30 997346.HMPREF9374_2730 4.09e-40 141.0 2DNID@1|root,32XP3@2|Bacteria,1UJYK@1239|Firmicutes 1239|Firmicutes S Cysteine-rich CPCC - - - - - - - - - - - - Cys_rich_CPCC k141_231_31 1408422.JHYF01000009_gene1992 1.62e-34 123.0 COG1669@1|root,COG1669@2|Bacteria,1VBHH@1239|Firmicutes,24JZE@186801|Clostridia,36JH2@31979|Clostridiaceae 186801|Clostridia S DNA polymerase beta domain protein region - - - - - - - - - - - - NTP_transf_2 k141_231_38 398512.JQKC01000094_gene3355 7.24e-06 48.5 COG4767@1|root,COG4767@2|Bacteria,1VKIA@1239|Firmicutes,24UFZ@186801|Clostridia 186801|Clostridia V VanZ like family - - - - - - - - - - - - VanZ k141_231_40 1476973.JMMB01000007_gene231 1.34e-32 115.0 COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,25RN8@186804|Peptostreptococcaceae 186801|Clostridia J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k141_231_41 1121324.CLIT_4c02010 1.2e-58 185.0 COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia 186801|Clostridia L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k141_231_42 1408823.AXUS01000015_gene1418 1.38e-32 114.0 COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,25RQP@186804|Peptostreptococcaceae 186801|Clostridia J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k141_231_43 1121324.CLIT_4c01990 1.3e-23 105.0 COG4241@1|root,COG4241@2|Bacteria,1V8P8@1239|Firmicutes,25CRW@186801|Clostridia 186801|Clostridia S Predicted membrane protein (DUF2232) - - - - - - - - - - - - DUF2232 k141_231_44 1292035.H476_0036 3.61e-275 776.0 COG3887@1|root,COG3887@2|Bacteria,1TPGP@1239|Firmicutes,2484R@186801|Clostridia,25QFS@186804|Peptostreptococcaceae 186801|Clostridia T DHHA1 domain protein yybT - - - - - - - - - - - DHH,DHHA1 k141_231_45 500633.CLOHIR_02133 1.84e-51 167.0 COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,25RF4@186804|Peptostreptococcaceae 186801|Clostridia J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k141_231_46 1286171.EAL2_c22060 3.69e-230 644.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,25VE8@186806|Eubacteriaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k141_231_47 1089548.KI783301_gene178 3.58e-17 90.1 2EU0H@1|root,33MHJ@2|Bacteria,1VKJD@1239|Firmicutes,4HVWZ@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - k141_231_49 1238184.CM001792_gene1771 1.1e-09 63.2 COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,4HH8Z@91061|Bacilli,23NG3@182709|Oceanobacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k141_231_50 768704.Desmer_3566 1.53e-120 359.0 COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,264PV@186807|Peptococcaceae 186801|Clostridia KT Response regulator receiver domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,PAS_3,Response_reg k141_231_51 929558.SMGD1_2022 8.08e-42 172.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YNJH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T His Kinase A (phospho-acceptor) domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - HATPase_c,HisKA,Hpt,PAS_9,Response_reg k141_231_52 1211814.CAPG01000082_gene3825 1.36e-08 60.1 COG4709@1|root,COG4709@2|Bacteria,1VBDQ@1239|Firmicutes,4HM00@91061|Bacilli,1ZFMM@1386|Bacillus 91061|Bacilli S Protein of unknown function (DUF1700) XK27_04830 - - - - - - - - - - - DUF1700 k141_231_55 1286171.EAL2_c21990 4.42e-235 655.0 COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,25V6G@186806|Eubacteriaceae 186801|Clostridia F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k141_226_1 1121129.KB903369_gene991 1.06e-47 161.0 COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,2FMMQ@200643|Bacteroidia,22WD0@171551|Porphyromonadaceae 976|Bacteroidetes U MotA TolQ ExbB proton channel family protein exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k141_241_24 1321778.HMPREF1982_04515 2.92e-77 246.0 COG1752@1|root,COG1752@2|Bacteria,1TRJW@1239|Firmicutes,248J0@186801|Clostridia 186801|Clostridia S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k141_241_25 1033737.CAEV01000077_gene692 3e-101 299.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,36DTB@31979|Clostridiaceae 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k141_241_28 1392491.JIAE01000001_gene2425 3.5e-52 180.0 COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia,3WHA2@541000|Ruminococcaceae 186801|Clostridia I lipid kinase, YegS Rv2252 BmrU family dagK - 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_cat k141_241_29 1121324.CLIT_23c01930 5.03e-307 856.0 COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia,25QCE@186804|Peptostreptococcaceae 186801|Clostridia G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 fbp - 3.1.3.11 ko:K04041 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_2 k141_241_30 632245.CLP_4219 1.69e-93 291.0 COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,36FJB@31979|Clostridiaceae 186801|Clostridia T SMART Metal-dependent phosphohydrolase, HD region rpfG1 - - - - - - - - - - - HD,HD_5 k141_241_31 1121324.CLIT_23c02680 3.02e-127 376.0 COG3853@1|root,COG3853@2|Bacteria,1TQVX@1239|Firmicutes,24A2H@186801|Clostridia,25QIY@186804|Peptostreptococcaceae 186801|Clostridia P Toxic anion resistance protein (TelA) - - - - - - - - - - - - TelA k141_241_32 1121324.CLIT_23c02690 1.42e-99 335.0 COG0265@1|root,COG0265@2|Bacteria,1UHT3@1239|Firmicutes,25EW9@186801|Clostridia 186801|Clostridia O Putative component of 'biosynthetic module' - - - - - - - - - - - - YceG_bac k141_241_33 386415.NT01CX_2306 1.71e-48 164.0 COG0789@1|root,COG0789@2|Bacteria,1V1M9@1239|Firmicutes,24FUE@186801|Clostridia,36KVK@31979|Clostridiaceae 186801|Clostridia K Domain of unknown function (DUF1836) - - - - - - - - - - - - DUF1836 k141_241_34 456320.Mvol_0341 1.38e-119 356.0 COG0530@1|root,arCOG02881@2157|Archaea,2XVHN@28890|Euryarchaeota,23QQ0@183939|Methanococci 183939|Methanococci P PFAM sodium calcium exchanger membrane region - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k141_241_35 386415.NT01CX_0667 1.26e-109 318.0 COG2310@1|root,COG2310@2|Bacteria,1TNZQ@1239|Firmicutes,24A3Y@186801|Clostridia,36GMM@31979|Clostridiaceae 186801|Clostridia T resistance protein terD_2 - - ko:K05795 - - - - ko00000 - - - TerD k141_241_36 929506.CbC4_2399 3.66e-108 315.0 COG2310@1|root,COG2310@2|Bacteria,1TNZQ@1239|Firmicutes,24DJD@186801|Clostridia,36W5A@31979|Clostridiaceae 186801|Clostridia T TerD domain - - - ko:K05795 - - - - ko00000 - - - TerD k141_241_37 1121324.CLIT_4c00480 2.52e-87 262.0 COG2310@1|root,COG2310@2|Bacteria,1TR98@1239|Firmicutes,24FZM@186801|Clostridia,25RAF@186804|Peptostreptococcaceae 186801|Clostridia T TerD domain yceC - - - - - - - - - - - TerD k141_241_38 1384057.CD33_08140 1.29e-113 343.0 COG2301@1|root,COG2301@2|Bacteria,1TSF2@1239|Firmicutes,4HCJB@91061|Bacilli,3IXS2@400634|Lysinibacillus 91061|Bacilli G Citrate lyase - - - - - - - - - - - - C-C_Bond_Lyase k141_241_39 666686.B1NLA3E_14265 1.01e-74 247.0 COG0503@1|root,COG0503@2|Bacteria,1UZSF@1239|Firmicutes,4HD0V@91061|Bacilli,1ZCGS@1386|Bacillus 91061|Bacilli F Phosphoribosyl transferase - - - - - - - - - - - - PRTase_2,TRSP k141_241_40 265729.GS18_0216690 1.92e-136 400.0 COG1358@1|root,COG1358@2|Bacteria,1TP5Y@1239|Firmicutes,4HEBY@91061|Bacilli,1ZDV5@1386|Bacillus 91061|Bacilli J Phosphoribosyl transferase (PRTase) - - - - - - - - - - - - PELOTA_1,PRTase_1 k141_241_41 445973.CLOBAR_01777 5.72e-48 167.0 COG0561@1|root,COG0561@2|Bacteria,1V24C@1239|Firmicutes,24HGT@186801|Clostridia,25RKV@186804|Peptostreptococcaceae 186801|Clostridia S Sucrose-6F-phosphate phosphohydrolase - - - - - - - - - - - - Hydrolase_3,S6PP k141_241_42 1511.CLOST_2363 1.12e-179 507.0 COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,25QKC@186804|Peptostreptococcaceae 186801|Clostridia D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k141_241_43 1408422.JHYF01000024_gene3841 3.99e-100 308.0 COG4786@1|root,COG4786@2|Bacteria,1TRFQ@1239|Firmicutes,24C2V@186801|Clostridia,36GJU@31979|Clostridiaceae 186801|Clostridia N flagellar basal body flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k141_241_44 1286171.EAL2_c03020 2e-104 311.0 COG4786@1|root,COG4786@2|Bacteria,1TT5Z@1239|Firmicutes,248M9@186801|Clostridia,25VE3@186806|Eubacteriaceae 186801|Clostridia N Flagellar basal body rod FlgEFG protein C-terminal flgG - - ko:K02390,ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k141_241_46 1301100.HG529419_gene3071 4.34e-81 243.0 COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,36IPJ@31979|Clostridiaceae 186801|Clostridia I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k141_241_47 272563.CD630_27800 1.03e-248 701.0 COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,25T3U@186804|Peptostreptococcaceae 186801|Clostridia G Phosphoglucomutase/phosphomannomutase, C-terminal domain pgcA - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k141_241_48 1511.CLOST_2359 1.25e-79 251.0 COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,25RPX@186804|Peptostreptococcaceae 186801|Clostridia S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k141_241_49 1286171.EAL2_c03070 1.75e-35 127.0 COG2426@1|root,COG2426@2|Bacteria,1V3UW@1239|Firmicutes,24HSW@186801|Clostridia,25WA3@186806|Eubacteriaceae 186801|Clostridia S small multi-drug export protein - - - - - - - - - - - - Sm_multidrug_ex k141_241_50 1121324.CLIT_13c00680 5.05e-114 333.0 COG0037@1|root,COG0037@2|Bacteria,1TQ0Y@1239|Firmicutes,247RP@186801|Clostridia 186801|Clostridia H Belongs to the TtcA family ttcA2 - - - - - - - - - - - ATP_bind_3 k141_241_52 1121289.JHVL01000007_gene2804 3.33e-203 566.0 COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,36UJ5@31979|Clostridiaceae 186801|Clostridia M NAD-dependent epimerase dehydratase - - 4.2.1.45,4.2.1.46 ko:K01709,ko:K01710 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R02426,R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k141_241_53 203119.Cthe_2644 2.87e-198 558.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,3WI7G@541000|Ruminococcaceae 186801|Clostridia E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k141_241_54 1511.CLOST_0365 3.48e-193 542.0 COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,1TRKP@1239|Firmicutes,248ZS@186801|Clostridia,25SUJ@186804|Peptostreptococcaceae 186801|Clostridia JM Nucleotidyl transferase - - 2.7.7.71 ko:K15669 ko00540,map00540 - R09772 RC00002 ko00000,ko00001,ko01000 - - - CBS,NTP_transferase k141_241_55 1242969.ATCC51562_1146 1.9e-134 389.0 COG0223@1|root,COG0223@2|Bacteria,1RAVE@1224|Proteobacteria,42NQD@68525|delta/epsilon subdivisions,2YNGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Formyl transferase - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k141_241_56 203119.Cthe_2641 8.77e-155 444.0 COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia,3WHC1@541000|Ruminococcaceae 186801|Clostridia M N-acetylneuraminate synthase neuB - 2.5.1.101,2.5.1.56 ko:K01654,ko:K18430 ko00520,ko01100,map00520,map01100 - R01804,R04435,R10304 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k141_241_57 796940.HMPREF9628_00643 6.74e-172 492.0 COG0381@1|root,COG0381@2|Bacteria,1TQKQ@1239|Firmicutes,24A0H@186801|Clostridia,25T09@186804|Peptostreptococcaceae 186801|Clostridia M UDP-N-acetylglucosamine 2-epimerase neuC - 3.2.1.184,5.1.3.14 ko:K01791,ko:K18429 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420,R10187 RC00005,RC00288,RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k141_241_58 871963.Desdi_3207 3.93e-131 383.0 COG0673@1|root,COG0673@2|Bacteria,1UTD8@1239|Firmicutes,24CI2@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k141_241_59 871963.Desdi_3206 1.83e-117 348.0 COG0673@1|root,COG0673@2|Bacteria,1UP62@1239|Firmicutes,24B2A@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k141_241_60 397288.C806_02761 5.79e-11 68.6 COG1083@1|root,COG1083@2|Bacteria,1UFAT@1239|Firmicutes,24G5I@186801|Clostridia,27JRG@186928|unclassified Lachnospiraceae 186801|Clostridia M Cytidylyltransferase neuA - 2.7.7.82 ko:K18431 ko00520,map00520 - R10182 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3 k141_241_61 1292035.H476_0069 2.25e-213 597.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,25QJU@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k141_241_62 140626.JHWB01000009_gene1210 3.88e-34 131.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_241_63 1391646.AVSU01000017_gene3118 7.2e-313 878.0 COG0272@1|root,COG0507@1|root,COG0272@2|Bacteria,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,25QNC@186804|Peptostreptococcaceae 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k141_241_64 1408823.AXUS01000007_gene3028 4.32e-42 151.0 COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,25RF0@186804|Peptostreptococcaceae 186801|Clostridia S ComF family comF - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran k141_241_65 1511.CLOST_2353 3.7e-45 150.0 2D61I@1|root,32TKA@2|Bacteria,1VB5H@1239|Firmicutes,24NZW@186801|Clostridia,25U2C@186804|Peptostreptococcaceae 186801|Clostridia N TIGRFAM flagellar operon protein yvyF - - - - - - - - - - - - k141_241_66 1304284.L21TH_2577 3.16e-08 53.9 COG2747@1|root,COG2747@2|Bacteria,1VKDG@1239|Firmicutes,24UWF@186801|Clostridia,36NY8@31979|Clostridiaceae 186801|Clostridia KNU Anti-sigma-28 factor, FlgM - - - ko:K02398 ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 - - - ko00000,ko00001,ko02035 - - - FlgM k141_241_67 1286171.EAL2_c03150 3.81e-35 127.0 29GQE@1|root,32MNN@2|Bacteria,1VQ2C@1239|Firmicutes 1239|Firmicutes S FlgN protein - - - - - - - - - - - - FlgN k141_241_68 1121324.CLIT_13c00780 2.21e-144 435.0 COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia 186801|Clostridia N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k141_241_69 1120972.AUMH01000031_gene997 5.57e-16 87.0 COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,4HCCZ@91061|Bacilli,278AV@186823|Alicyclobacillaceae 91061|Bacilli N Belongs to the bacterial flagellin family flgL GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_241_70 1184267.A11Q_575 2.71e-16 79.0 COG1699@1|root,COG1699@2|Bacteria,1N9E7@1224|Proteobacteria,42V88@68525|delta/epsilon subdivisions,2MT3S@213481|Bdellovibrionales,2WR7H@28221|Deltaproteobacteria 213481|Bdellovibrionales T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW k141_241_71 1121324.CLIT_13c00810 1.67e-14 68.9 COG1551@1|root,COG1551@2|Bacteria 2|Bacteria T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k141_241_72 562743.JH976434_gene1127 8.64e-65 211.0 COG1344@1|root,COG1344@2|Bacteria,1TP9Z@1239|Firmicutes,4HCW9@91061|Bacilli 91061|Bacilli N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_241_75 999411.HMPREF1092_01510 2.41e-105 313.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia,36ED6@31979|Clostridiaceae 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_241_76 1230342.CTM_08366 4.95e-137 422.0 COG2604@1|root,COG2604@2|Bacteria,1U2BC@1239|Firmicutes,24CSU@186801|Clostridia,36G68@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF115 - - - - - - - - - - - - MAF_flag10 k141_241_77 439235.Dalk_0647 5.29e-06 50.1 COG1334@1|root,COG1334@2|Bacteria 2|Bacteria N flagellar protein FlaG flaG - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG k141_241_78 1121324.CLIT_13c00940 3.67e-124 382.0 COG1345@1|root,COG1345@2|Bacteria,1TQ66@1239|Firmicutes,248Q9@186801|Clostridia,25SRV@186804|Peptostreptococcaceae 186801|Clostridia N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k141_241_79 1286171.EAL2_c03470 2.22e-55 176.0 COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia,25X2K@186806|Eubacteriaceae 186801|Clostridia N Flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k141_241_81 913865.DOT_5370 6.01e-09 53.9 2DR71@1|root,33AGR@2|Bacteria,1VKHI@1239|Firmicutes,25IF8@186801|Clostridia,266P5@186807|Peptococcaceae 186801|Clostridia S Putative motility protein - - - - - - - - - - - - YjfB_motility k141_241_83 1443122.Z958_08245 1.63e-59 206.0 COG2604@1|root,COG2604@2|Bacteria,1V4NE@1239|Firmicutes,24CPP@186801|Clostridia,36GUD@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF115 - - - - - - - - - - - - MAF_flag10 k141_241_85 1511.CLOST_2321 4.96e-75 242.0 COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia,25RRC@186804|Peptostreptococcaceae 186801|Clostridia C ATP synthase (C/AC39) subunit ntpC - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k141_241_86 1286171.EAL2_c03510 1.11e-150 458.0 COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,25W06@186806|Eubacteriaceae 186801|Clostridia U V-type ATPase 116kDa subunit family ntpI - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k141_241_87 1304284.L21TH_0591 2.69e-38 134.0 COG0636@1|root,COG0636@2|Bacteria,1VAGE@1239|Firmicutes,24RB6@186801|Clostridia,36K54@31979|Clostridiaceae 186801|Clostridia C ATP synthase, subunit C - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k141_37_10 1118055.CAGU01000046_gene1658 1.89e-92 284.0 COG3649@1|root,COG3649@2|Bacteria,1UKQK@1239|Firmicutes,24C9C@186801|Clostridia,22H07@1570339|Peptoniphilaceae 186801|Clostridia L Pfam:DUF694 - - - ko:K19115 - - - - ko00000,ko02048 - - - Cas_Cas7 k141_37_11 1499683.CCFF01000017_gene1488 4.88e-50 189.0 28JMD@1|root,2Z9DX@2|Bacteria,1UM68@1239|Firmicutes,24CYH@186801|Clostridia,36FSY@31979|Clostridiaceae 186801|Clostridia - - csh - - ko:K19114 - - - - ko00000,ko02048 - - - - k141_37_15 1410653.JHVC01000014_gene3430 1.46e-24 99.8 COG2963@1|root,COG2963@2|Bacteria,1V4FD@1239|Firmicutes,24GUY@186801|Clostridia,36I6D@31979|Clostridiaceae 186801|Clostridia L hmm pf01527 - - - - - - - - - - - - HTH_28,HTH_Tnp_1 k141_37_16 756499.Desde_1540 1.59e-40 137.0 COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24N2T@186801|Clostridia,266XR@186807|Peptococcaceae 186801|Clostridia K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k141_37_17 1211817.CCAT010000084_gene1822 7.07e-48 159.0 COG2153@1|root,COG2153@2|Bacteria,1VAJY@1239|Firmicutes,24JG3@186801|Clostridia,36JM2@31979|Clostridiaceae 186801|Clostridia S Acetyltransferase (GNAT) domain - - - ko:K02348 - - - - ko00000 - - - Acetyltransf_10 k141_37_18 536232.CLM_1224 2.7e-250 711.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia,36FYC@31979|Clostridiaceae 186801|Clostridia S ABC transporter yfmR - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k141_37_19 1499689.CCNN01000007_gene1141 1.16e-115 345.0 COG1482@1|root,COG1482@2|Bacteria,1V0PH@1239|Firmicutes,2487K@186801|Clostridia,36E6K@31979|Clostridiaceae 186801|Clostridia G mannose-6-phosphate isomerase, class I manA - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS19425 PMI_typeI k141_37_20 1408438.JADD01000010_gene1893 3.69e-39 146.0 COG0561@1|root,COG0561@2|Bacteria,1V5FB@1239|Firmicutes,4HGY8@91061|Bacilli,27EKX@186827|Aerococcaceae 91061|Bacilli S Sucrose-6F-phosphate phosphohydrolase ycsE - - - - - - - - - - - Hydrolase_3 k141_37_21 326423.RBAM_033520 2.61e-60 198.0 COG1349@1|root,COG1349@2|Bacteria,1V1VH@1239|Firmicutes,4HG12@91061|Bacilli,1ZN25@1386|Bacillus 91061|Bacilli K DeoR C terminal sensor domain glcR - - ko:K22103 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k141_37_22 572479.Hprae_1147 3.66e-24 94.0 COG4675@1|root,COG4675@2|Bacteria,1V943@1239|Firmicutes,24PFY@186801|Clostridia 186801|Clostridia S PFAM Tail Collar domain protein - - - - - - - - - - - - Collar k141_37_23 572479.Hprae_1147 1.39e-26 99.8 COG4675@1|root,COG4675@2|Bacteria,1V943@1239|Firmicutes,24PFY@186801|Clostridia 186801|Clostridia S PFAM Tail Collar domain protein - - - - - - - - - - - - Collar k141_37_24 985665.HPL003_10875 4.33e-31 112.0 COG4675@1|root,COG4675@2|Bacteria,1V943@1239|Firmicutes,4HJCC@91061|Bacilli,26YNV@186822|Paenibacillaceae 91061|Bacilli S Phage Tail Collar Domain - - - - - - - - - - - - Collar k141_37_25 485916.Dtox_2342 1.06e-41 155.0 COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria,1VG2U@1239|Firmicutes,24JBU@186801|Clostridia,265E6@186807|Peptococcaceae 186801|Clostridia DNZ PFAM coagulation factor 5 8 type domain protein - - - - - - - - - - - - CW_binding_1,Cadherin-like,F5_F8_type_C k141_37_26 562970.Btus_1884 2.88e-34 153.0 COG5184@1|root,COG5184@2|Bacteria,1UM5S@1239|Firmicutes,4ITQP@91061|Bacilli,279WZ@186823|Alicyclobacillaceae 91061|Bacilli DMZ Cadherin-like beta sandwich domain - - - - - - - - - - - - Cadherin-like,SLH k141_91_1 1511.CLOST_2394 1.85e-140 409.0 COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia,25QDJ@186804|Peptostreptococcaceae 186801|Clostridia E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k141_91_2 1415775.U729_1846 1.63e-57 194.0 COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,36FBC@31979|Clostridiaceae 186801|Clostridia F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03525 GHMP_kinases_C,GHMP_kinases_N k141_91_3 1121324.CLIT_14c00020 4.97e-57 181.0 COG4492@1|root,COG4492@2|Bacteria,1VAJ9@1239|Firmicutes,24MTS@186801|Clostridia,25TTI@186804|Peptostreptococcaceae 186801|Clostridia S Belongs to the UPF0735 family pheB - 5.4.99.5 ko:K06209 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4 k141_93_1 1408422.JHYF01000004_gene1456 1.2e-26 102.0 COG0416@1|root,COG0416@2|Bacteria,1TPY8@1239|Firmicutes,248BX@186801|Clostridia,36EUZ@31979|Clostridiaceae 186801|Clostridia I PFAM fatty acid synthesis plsX protein grdD - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K21576 - - - - ko00000,ko01000 - - - FA_synthesis k141_93_2 1286171.EAL2_c02920 4.36e-233 655.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,25V4W@186806|Eubacteriaceae 186801|Clostridia U BCCT, betaine/carnitine/choline family transporter opuD - - ko:K05020 - - - - ko00000,ko02000 2.A.15.1.1,2.A.15.1.11 - - BCCT k141_93_3 1123009.AUID01000013_gene1733 7.17e-157 447.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,26861@186813|unclassified Clostridiales 186801|Clostridia C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k141_93_4 929506.CbC4_2389 5.36e-70 223.0 COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae 186801|Clostridia M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k141_93_6 1347392.CCEZ01000019_gene1031 1.42e-262 744.0 COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,36DEB@31979|Clostridiaceae 186801|Clostridia S oligopeptide transporter, OPT family - - - - - - - - - - - - OPT k141_93_7 1259795.ARJK01000003_gene1041 7.76e-23 92.4 2E6A2@1|root,330XY@2|Bacteria,1U5UB@1239|Firmicutes,25NDK@186801|Clostridia,42IJU@68295|Thermoanaerobacterales 186801|Clostridia S Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD k141_93_9 1540257.JQMW01000013_gene1163 7.08e-228 641.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,36F13@31979|Clostridiaceae 186801|Clostridia E amino acid carrier protein glnT - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k141_93_10 1121936.AUHI01000006_gene2035 8.78e-12 76.6 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_70_2 350688.Clos_2869 7e-81 251.0 COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,2488X@186801|Clostridia,36DCH@31979|Clostridiaceae 186801|Clostridia K Belongs to the ParB family noc - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k141_243_445 1511.CLOST_1106 1.63e-101 305.0 COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,247ST@186801|Clostridia 186801|Clostridia T EDD domain protein, DegV family - - - - - - - - - - - - DegV k141_243_446 1286171.EAL2_c08720 4.2e-75 237.0 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia,25W2S@186806|Eubacteriaceae 186801|Clostridia S EDD domain protein, DegV family - - - - - - - - - - - - DegV k141_243_447 411468.CLOSCI_00776 1.47e-17 79.7 2E36T@1|root,32Y6H@2|Bacteria,1VEXQ@1239|Firmicutes,24RAE@186801|Clostridia,22420@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k141_243_448 1123009.AUID01000013_gene1733 3.07e-152 436.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,26861@186813|unclassified Clostridiales 186801|Clostridia C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k141_243_449 1151292.QEW_2891 3.86e-46 150.0 COG3118@1|root,COG3118@2|Bacteria,1UHX3@1239|Firmicutes,24JPM@186801|Clostridia,25RVE@186804|Peptostreptococcaceae 186801|Clostridia O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k141_243_450 1121324.CLIT_20c00930 1.86e-242 674.0 28HF7@1|root,2Z7RC@2|Bacteria,1TQET@1239|Firmicutes,249YW@186801|Clostridia,25QXA@186804|Peptostreptococcaceae 186801|Clostridia C Glycine/sarcosine/betaine reductase component B subunits grdE - 1.21.4.2 ko:K10671 - - - - ko00000,ko01000 - - - Gly_reductase k141_243_451 293826.Amet_3592 4.25e-16 73.6 2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia,36JTG@31979|Clostridiaceae 186801|Clostridia C In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination grdA - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K10670 - - - - ko00000,ko01000 - - - GRDA k141_243_452 1121289.JHVL01000018_gene609 4.11e-52 166.0 2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia,36JTG@31979|Clostridiaceae 186801|Clostridia C In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination grdA - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K10670 - - - - ko00000,ko01000 - - - GRDA k141_243_453 562983.HMPREF0433_00601 3.79e-167 476.0 COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,4HDWJ@91061|Bacilli,3WEP2@539002|Bacillales incertae sedis 91061|Bacilli S Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - - - - - - - - - - GRDB k141_243_454 293826.Amet_3591 5.36e-31 119.0 COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,36DEZ@31979|Clostridiaceae 186801|Clostridia S glycine betaine sarcosine D-proline reductase family - - 1.21.4.2 ko:K10672 - - - - ko00000,ko01000 - - - GRDB k141_244_1 1270196.JCKI01000013_gene3205 0.0 889.0 28IN7@1|root,2Z8NM@2|Bacteria,4NHTH@976|Bacteroidetes 976|Bacteroidetes S Capsid protein (F protein) - - - - - - - - - - - - Phage_F k141_244_2 1286632.P278_33670 1.35e-19 79.0 2EFW9@1|root,339NJ@2|Bacteria,4P71N@976|Bacteroidetes,1I6VT@117743|Flavobacteriia 976|Bacteroidetes S Microvirus J protein - - - - - - - - - - - - Microvir_J k141_244_3 1288298.rosmuc_01661 4.9e-103 298.0 28HVF@1|root,2Z81Q@2|Bacteria,1NZPF@1224|Proteobacteria 1224|Proteobacteria S Bacteriophage scaffolding protein D - - - - - - - - - - - - gpD k141_244_4 1270196.JCKI01000013_gene3202 4.42e-56 174.0 2AGWD@1|root,3174S@2|Bacteria 2|Bacteria S Phage protein C - - - - - - - - - - - - Phage_C k141_244_5 1286632.P278_33700 0.0 1035.0 28I9J@1|root,2Z8C8@2|Bacteria,4P06R@976|Bacteroidetes,1I7XB@117743|Flavobacteriia 976|Bacteroidetes S Bacteriophage replication gene A protein (GPA) - - - - - - - - - - - - Phage_GPA k141_244_6 1288298.rosmuc_01659 6.62e-188 527.0 2DBBW@1|root,2Z8AR@2|Bacteria,1R492@1224|Proteobacteria,2UP8C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Microvirus H protein (pilot protein) - - - - - - - - - - - - Microvir_H k141_244_7 1286632.P278_33640 2.15e-124 354.0 28HGS@1|root,2Z7SJ@2|Bacteria,4NERU@976|Bacteroidetes,1HZIZ@117743|Flavobacteriia 976|Bacteroidetes S Major spike protein (G protein) - - - - - - - - - - - - Phage_G k141_149_38 1230342.CTM_14363 1.52e-166 512.0 COG0210@1|root,COG0210@2|Bacteria,1TRTJ@1239|Firmicutes,24BBH@186801|Clostridia,36EJQ@31979|Clostridiaceae 186801|Clostridia L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - RNase_T,UvrD-helicase,UvrD_C,UvrD_C_2 k141_216_2 1286171.EAL2_c00180 5.73e-75 230.0 COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,25YPK@186806|Eubacteriaceae 186801|Clostridia L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k141_216_4 536227.CcarbDRAFT_5355 3.24e-94 283.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,36F1K@31979|Clostridiaceae 186801|Clostridia S (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC k141_216_5 445973.CLOBAR_00658 4.55e-82 253.0 COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,25RGQ@186804|Peptostreptococcaceae 186801|Clostridia S Protein of unknown function DUF111 larC - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k141_216_6 1151292.QEW_0223 1.56e-40 139.0 COG1641@1|root,COG1641@2|Bacteria,1V4CM@1239|Firmicutes,24Q1I@186801|Clostridia,25RJ9@186804|Peptostreptococcaceae 186801|Clostridia S Protein of unknown function DUF111 - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k141_216_7 1121324.CLIT_20c00330 1.1e-266 740.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k141_216_8 1391646.AVSU01000015_gene3021 2.42e-292 807.0 COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,25QVV@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k141_216_10 1235802.C823_02022 6.17e-12 73.2 COG4249@1|root,COG4249@2|Bacteria,1V3F2@1239|Firmicutes,24G71@186801|Clostridia 186801|Clostridia S Caspase domain - - - - - - - - - - - - Peptidase_C14 k141_216_13 1321778.HMPREF1982_02509 5.29e-166 476.0 COG1106@1|root,COG1106@2|Bacteria,1TRQ5@1239|Firmicutes,24BS2@186801|Clostridia 186801|Clostridia S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K06926 - - - - ko00000 - - - AAA_21 k141_216_14 1347368.HG964406_gene6340 4.07e-164 476.0 COG1106@1|root,COG1106@2|Bacteria,1TPJN@1239|Firmicutes,4HCWK@91061|Bacilli,1ZN35@1386|Bacillus 91061|Bacilli S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_21,AAA_23 k141_216_15 1285586.H131_00506 1.37e-31 121.0 2ASKI@1|root,31I16@2|Bacteria,1V2J9@1239|Firmicutes,4HMKP@91061|Bacilli,3IXQ5@400634|Lysinibacillus 91061|Bacilli S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_216_17 1294142.CINTURNW_4055 2.37e-31 122.0 COG3279@1|root,COG3279@2|Bacteria,1V392@1239|Firmicutes,248ZQ@186801|Clostridia,36F65@31979|Clostridiaceae 186801|Clostridia K response regulator agrA - - ko:K07707 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k141_216_18 1121324.CLIT_20c00350 2.59e-209 591.0 COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,25R1F@186804|Peptostreptococcaceae 186801|Clostridia S permease - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k141_216_19 272844.PAB1077 3.84e-54 176.0 COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,24415@183968|Thermococci 183968|Thermococci F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k141_216_20 1476973.JMMB01000007_gene454 5.83e-109 320.0 COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,25RAA@186804|Peptostreptococcaceae 186801|Clostridia F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k141_216_21 1121324.CLIT_20c00380 5.31e-229 641.0 COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,25QKT@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k141_216_22 1511.CLOST_0336 1.68e-134 394.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,25QF2@186804|Peptostreptococcaceae 186801|Clostridia F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k141_216_23 1304284.L21TH_1808 2.1e-71 222.0 COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,36I7J@31979|Clostridiaceae 186801|Clostridia F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04225 Formyl_trans_N k141_216_24 1121324.CLIT_20c00410 3.91e-235 662.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,25QUK@186804|Peptostreptococcaceae 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS04230 AICARFT_IMPCHas,MGS k141_216_25 1121289.JHVL01000031_gene365 5.51e-148 433.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,36EPV@31979|Clostridiaceae 186801|Clostridia F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k141_216_26 1443125.Z962_06510 0.0 1353.0 COG0046@1|root,COG0047@1|root,COG0151@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,COG0151@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,36UJE@31979|Clostridiaceae 186801|Clostridia F phosphoribosylformylglycinamidine synthase purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k141_216_27 981383.AEWH01000020_gene2506 2.33e-38 143.0 2DC01@1|root,2ZC51@2|Bacteria,1V2FW@1239|Firmicutes,4HG69@91061|Bacilli 91061|Bacilli S TraX protein - - - - - - - - - - - - TraX k141_216_28 1304284.L21TH_1331 2.32e-61 199.0 COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,36EYH@31979|Clostridiaceae 186801|Clostridia S MgtC SapB transporter - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k141_216_29 877424.ATWC01000019_gene1022 4.11e-44 164.0 COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,25AZS@186801|Clostridia,27K6D@186928|unclassified Lachnospiraceae 186801|Clostridia T HD domain - - - - - - - - - - - - HD,HD_5 k141_216_30 743719.PaelaDRAFT_1110 2.64e-10 68.9 COG0715@1|root,COG0715@2|Bacteria,1V86M@1239|Firmicutes,4I6K6@91061|Bacilli,26TFH@186822|Paenibacillaceae 91061|Bacilli P Nitrate ABC transporter substrate-binding protein - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k141_216_31 985255.APHJ01000023_gene2674 9.11e-59 224.0 COG0642@1|root,COG2202@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HY32@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k141_216_32 1476973.JMMB01000007_gene490 3.97e-111 326.0 COG0560@1|root,COG0560@2|Bacteria,1UYZ6@1239|Firmicutes,24AC7@186801|Clostridia,25QBY@186804|Peptostreptococcaceae 186801|Clostridia E HAD hydrolase, family IB serB - - - - - - - - - - - HAD k141_216_33 1219626.HMPREF1639_00800 3.97e-55 193.0 2DKA9@1|root,32UEQ@2|Bacteria,1VE7Y@1239|Firmicutes,24KB2@186801|Clostridia,25R3C@186804|Peptostreptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_216_34 1304284.L21TH_2057 1.21e-232 669.0 COG0849@1|root,COG0849@2|Bacteria,1TP1Z@1239|Firmicutes,249Y7@186801|Clostridia,36DWK@31979|Clostridiaceae 186801|Clostridia D cell division protein FtsA ftsA - - - - - - - - - - - FtsA,MreB_Mbl k141_216_37 1476973.JMMB01000007_gene503 2.57e-187 536.0 COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,25QME@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k141_216_38 1408823.AXUS01000010_gene1892 1.3e-129 379.0 COG1270@1|root,COG1270@2|Bacteria,1TQ3X@1239|Firmicutes,247PR@186801|Clostridia,25QMF@186804|Peptostreptococcaceae 186801|Clostridia H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k141_216_39 1157637.KB892155_gene7739 2.26e-08 61.2 COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria 201174|Actinobacteria T response regulator, receiver - - - ko:K02479 - - - - ko00000,ko02022 - - - GerE,Response_reg k141_216_41 1211817.CCAT010000044_gene3350 4.14e-06 54.3 COG1664@1|root,COG1664@2|Bacteria,1V6E6@1239|Firmicutes,24E2Y@186801|Clostridia,36GS1@31979|Clostridiaceae 186801|Clostridia M COG1664 Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k141_216_43 272563.CD630_34320 3.48e-112 337.0 COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,25R5H@186804|Peptostreptococcaceae 186801|Clostridia E Aminotransferase class I and II cobD2 - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS15770 Aminotran_1_2 k141_216_44 555079.Toce_1423 3.6e-37 141.0 COG4542@1|root,COG4542@2|Bacteria,1TSJB@1239|Firmicutes,24I5S@186801|Clostridia,42GB5@68295|Thermoanaerobacterales 186801|Clostridia Q COGs COG4542 Protein involved in propanediol utilization and related protein (includes coumermycin biosynthetic protein) pduX - 2.7.1.177 ko:K16651 ko00860,map00860 - R06531 RC00002,RC00428 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k141_216_45 1151292.QEW_4052 4.19e-89 268.0 COG2082@1|root,COG2082@2|Bacteria,1V1SX@1239|Firmicutes,24B9Z@186801|Clostridia,25R69@186804|Peptostreptococcaceae 186801|Clostridia H Precorrin-8X methylmutase cobH - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiC k141_216_46 1408823.AXUS01000010_gene1896 1.36e-131 389.0 COG1903@1|root,COG1903@2|Bacteria,1TQ3M@1239|Firmicutes,248AK@186801|Clostridia,25QCM@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k141_216_47 1151292.QEW_4050 1.83e-73 228.0 COG2241@1|root,COG2241@2|Bacteria,1V832@1239|Firmicutes,24JES@186801|Clostridia,25QJX@186804|Peptostreptococcaceae 186801|Clostridia H Precorrin-6y C5,15-methyltransferase (Decarboxylating) cbiE - 2.1.1.132,2.1.1.289 ko:K00595,ko:K03399 ko00860,ko01100,map00860,map01100 - R05149,R05813,R07775 RC00003,RC01279,RC02052,RC02053 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS15725 TP_methylase k141_216_48 272563.CD630_34270 3.96e-50 167.0 COG2242@1|root,COG2242@2|Bacteria,1TS3H@1239|Firmicutes,2483G@186801|Clostridia,25RAJ@186804|Peptostreptococcaceae 186801|Clostridia H Putative methyltransferase cbiT - 2.1.1.132,2.1.1.196 ko:K00595,ko:K02191 ko00860,ko01100,map00860,map01100 - R05149,R05813,R07774 RC00003,RC01279,RC02052,RC02054 ko00000,ko00001,ko01000 - - - CbiJ,Cons_hypoth95,MTS,Met_10,Methyltransf_31,Methyltransf_4,PCMT,TP_methylase k141_216_49 1301100.HG529436_gene6546 6.87e-99 295.0 COG2243@1|root,COG2243@2|Bacteria,1TP87@1239|Firmicutes,249DM@186801|Clostridia,36DZI@31979|Clostridiaceae 186801|Clostridia H Precorrin-2 C(20)-methyltransferase cobI - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k141_216_50 1301100.HG529436_gene6551 2.82e-135 388.0 COG2875@1|root,COG2875@2|Bacteria,1TP6J@1239|Firmicutes,248IZ@186801|Clostridia,36DW3@31979|Clostridiaceae 186801|Clostridia H Precorrin-4 C(11)-methyltransferase cobM - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k141_216_51 656519.Halsa_2195 4.98e-13 79.0 COG2073@1|root,COG2073@2|Bacteria,1TPYM@1239|Firmicutes,247JW@186801|Clostridia,3WBC2@53433|Halanaerobiales 186801|Clostridia H PFAM cobalamin (vitamin B12) biosynthesis CbiG protein cbiG - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS15705 CbiG_C,CbiG_N,CbiG_mid k141_216_52 500633.CLOHIR_00706 3.44e-119 346.0 COG1010@1|root,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,247QS@186801|Clostridia,25QEW@186804|Peptostreptococcaceae 186801|Clostridia H precorrin-3B C17-methyltransferase cobJ - 2.1.1.131,2.1.1.272 ko:K05934,ko:K21479 ko00860,ko01100,map00860,map01100 - R05180,R05809,R11580 RC00003,RC01293,RC03471,RC03479 ko00000,ko00001,ko01000 - - - TP_methylase k141_216_53 1219626.HMPREF1639_05650 1.41e-62 203.0 COG2099@1|root,COG2099@2|Bacteria,1UHWY@1239|Firmicutes,24GIQ@186801|Clostridia,25QQ6@186804|Peptostreptococcaceae 186801|Clostridia H reductase cobK - 1.3.1.106,1.3.1.54 ko:K05895 ko00860,ko01100,map00860,map01100 - R05150,R05812 RC01280 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS15690 CbiJ k141_216_54 1347392.CCEZ01000019_gene967 3.99e-143 421.0 COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,36EQI@31979|Clostridiaceae 186801|Clostridia H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k141_216_55 888055.HMPREF9015_02127 4.22e-27 108.0 COG1648@1|root,COG1648@2|Bacteria,37A4S@32066|Fusobacteria 32066|Fusobacteria H Siroheme synthase domain protein - - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7 k141_216_56 1391646.AVSU01000047_gene1599 6.71e-107 320.0 COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,2494Z@186801|Clostridia,25QEM@186804|Peptostreptococcaceae 186801|Clostridia H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15760 Porphobil_deam,Porphobil_deamC k141_216_57 386415.NT01CX_0261 1.29e-194 558.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,36DBR@31979|Clostridiaceae 186801|Clostridia H Belongs to the precorrin methyltransferase family cobA - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15755 HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase k141_216_58 500633.CLOHIR_01522 5.13e-163 464.0 COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,25QF1@186804|Peptostreptococcaceae 186801|Clostridia H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k141_216_59 386415.NT01CX_0259 1.39e-219 616.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,36FBX@31979|Clostridiaceae 186801|Clostridia H Aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k141_216_60 573061.Clocel_4255 1.28e-15 79.7 COG4512@1|root,COG4512@2|Bacteria,1VJBI@1239|Firmicutes,24GSH@186801|Clostridia,36I74@31979|Clostridiaceae 186801|Clostridia KOT May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor - - - ko:K07813 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001,ko01002 - - - AgrB k141_216_61 386415.NT01CX_2062 3.04e-32 135.0 COG3290@1|root,COG3290@2|Bacteria,1UYTM@1239|Firmicutes,24CUA@186801|Clostridia,36FUX@31979|Clostridiaceae 186801|Clostridia T GHKL domain - - 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c_5 k141_152_1 313603.FB2170_09861 3.18e-07 57.8 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,1HWKQ@117743|Flavobacteriia,2PG8A@252356|Maribacter 976|Bacteroidetes S TamB, inner membrane protein subunit of TAM complex - - - - - - - - - - - - TamB k141_153_1 1121129.KB903360_gene3484 1.35e-119 369.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,2FMFA@200643|Bacteroidia,22WUH@171551|Porphyromonadaceae 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k141_154_1 742817.HMPREF9449_00456 4.42e-111 336.0 COG1530@1|root,COG1530@2|Bacteria,4NED1@976|Bacteroidetes,2FMXV@200643|Bacteroidia,22WM6@171551|Porphyromonadaceae 976|Bacteroidetes J ribonuclease G rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k141_223_1 1002367.HMPREF0673_03030 1.5e-07 52.8 COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,2FPQX@200643|Bacteroidia 976|Bacteroidetes MU Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - CarboxypepD_reg,OmpA,PD40 k141_223_2 391587.KAOT1_01190 5.38e-59 193.0 COG0150@1|root,COG0150@2|Bacteria,4NE4E@976|Bacteroidetes,1HXGD@117743|Flavobacteriia 976|Bacteroidetes F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k141_73_4 1511.CLOST_2001 2.21e-149 430.0 COG3641@1|root,COG3641@2|Bacteria,1TS5F@1239|Firmicutes,247P0@186801|Clostridia,25QPN@186804|Peptostreptococcaceae 186801|Clostridia S Phosphotransferase system, EIIC - - - ko:K07035 - - - - ko00000 - - - PTS_EIIC_2 k141_73_5 1499683.CCFF01000002_gene3 7.23e-48 160.0 COG1827@1|root,COG1827@2|Bacteria,1V6EY@1239|Firmicutes,24JF2@186801|Clostridia,36IFU@31979|Clostridiaceae 186801|Clostridia S 3H domain niaR - - ko:K07105 - - - - ko00000 - - - 3H,HTH_11 k141_73_6 1121324.CLIT_16c00130 0.0 1066.0 COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,25SRS@186804|Peptostreptococcaceae 186801|Clostridia S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k141_18_51 44251.PDUR_02870 8.37e-29 111.0 2AQIU@1|root,31FRM@2|Bacteria,1V721@1239|Firmicutes,4HJ29@91061|Bacilli,272M3@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k141_18_69 1319815.HMPREF0202_01332 6.79e-180 511.0 COG2309@1|root,COG2309@2|Bacteria,379GR@32066|Fusobacteria 32066|Fusobacteria E Thermophilic metalloprotease (M29) - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 k141_18_70 545243.BAEV01000004_gene865 8.53e-77 252.0 COG0038@1|root,COG0038@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,36FR4@31979|Clostridiaceae 186801|Clostridia P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k141_18_71 929506.CbC4_2527 1.73e-46 162.0 COG5522@1|root,COG5522@2|Bacteria,1V4XE@1239|Firmicutes,24Q8V@186801|Clostridia,36KVT@31979|Clostridiaceae 186801|Clostridia S Integral membrane protein (intg_mem_TP0381) - - - - - - - - - - - - Intg_mem_TP0381 k141_18_72 469617.FUAG_01434 8.87e-246 696.0 COG0006@1|root,COG0006@2|Bacteria,379FB@32066|Fusobacteria 32066|Fusobacteria E Creatinase/Prolidase N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k141_18_73 1230342.CTM_23779 4.37e-165 470.0 COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,36EJ8@31979|Clostridiaceae 186801|Clostridia E Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide hutG - 3.5.3.8 ko:K01479 ko00340,ko01100,map00340,map01100 M00045 R02285 RC00221,RC00681 ko00000,ko00001,ko00002,ko01000 - - - Arginase k141_18_74 1511.CLOST_0529 2.7e-32 122.0 2BYUV@1|root,307Y4@2|Bacteria,1V64G@1239|Firmicutes,24K9A@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_18_75 536227.CcarbDRAFT_3925 2.18e-101 317.0 COG2897@1|root,COG2897@2|Bacteria,1TS7E@1239|Firmicutes,24CNW@186801|Clostridia,36DJP@31979|Clostridiaceae 186801|Clostridia P domain protein - - 2.8.1.11 ko:K21028 ko04122,map04122 - R07461 - ko00000,ko00001,ko01000 - - - Rhodanese k141_18_77 1499689.CCNN01000006_gene563 5.6e-74 234.0 COG2897@1|root,COG2897@2|Bacteria,1TRYA@1239|Firmicutes,24GYI@186801|Clostridia,36I1B@31979|Clostridiaceae 186801|Clostridia P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k141_18_78 1541959.KQ51_01091 3.82e-31 125.0 COG2199@1|root,COG3706@2|Bacteria,3WUMW@544448|Tenericutes 544448|Tenericutes T PAS fold - - - - - - - - - - - - GGDEF,PAS_9 k141_18_79 1121324.CLIT_5c00610 2.33e-176 503.0 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,25QNU@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI k141_18_80 1391646.AVSU01000056_gene1286 6.61e-152 441.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25R11@186804|Peptostreptococcaceae 186801|Clostridia E Aminotransferase class-V iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k141_18_81 1033737.CAEV01000097_gene1837 2.89e-59 199.0 COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,247ZD@186801|Clostridia,36U61@31979|Clostridiaceae 186801|Clostridia S Phenazine biosynthesis-like protein - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k141_18_82 272563.CD630_07490 4.55e-194 570.0 COG0210@1|root,COG0210@2|Bacteria,1TPVG@1239|Firmicutes,2484I@186801|Clostridia,25QTG@186804|Peptostreptococcaceae 186801|Clostridia L DNA helicase yjcD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k141_18_83 1304284.L21TH_1234 4.84e-37 142.0 COG3359@1|root,COG3359@2|Bacteria,1U725@1239|Firmicutes,24A9V@186801|Clostridia,36DD2@31979|Clostridiaceae 186801|Clostridia L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k141_18_84 1321778.HMPREF1982_04262 6.53e-213 597.0 COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,2688K@186813|unclassified Clostridiales 186801|Clostridia G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k141_18_85 522772.Dacet_1991 6.86e-30 129.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GGDEF,PAS,PAS_4 k141_18_86 350688.Clos_1842 2.75e-46 155.0 COG3366@1|root,COG3366@2|Bacteria,1UHXB@1239|Firmicutes,24PK4@186801|Clostridia,36UUG@31979|Clostridiaceae 186801|Clostridia S PFAM nucleoside recognition domain protein - - - - - - - - - - - - Gate k141_18_87 1408422.JHYF01000013_gene481 8.28e-46 152.0 COG0370@1|root,COG0370@2|Bacteria,1TQT3@1239|Firmicutes,24MTG@186801|Clostridia,36MDA@31979|Clostridiaceae 186801|Clostridia P Nucleoside recognition - - - - - - - - - - - - Gate k141_18_88 941824.TCEL_02243 1.56e-105 315.0 COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,36FBW@31979|Clostridiaceae 186801|Clostridia F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k141_18_89 446470.Snas_5039 3.2e-16 81.3 COG3404@1|root,COG3404@2|Bacteria,2IIRF@201174|Actinobacteria,4EYGJ@85014|Glycomycetales 201174|Actinobacteria E Formiminotransferase-cyclodeaminase - - - - - - - - - - - - FTCD_C k141_18_90 1391646.AVSU01000056_gene1308 6.13e-294 815.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,25QRD@186804|Peptostreptococcaceae 186801|Clostridia H Formyltetrahydrofolate synthetase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k141_18_91 1031288.AXAA01000003_gene1616 1.92e-79 241.0 COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,36EM4@31979|Clostridiaceae 186801|Clostridia C Fe-S type, tartrate fumarate subfamily, beta fumB - 4.2.1.2 ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C k141_18_92 1209989.TepiRe1_0545 7.33e-129 374.0 COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,42EX5@68295|Thermoanaerobacterales 186801|Clostridia C hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit - - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase k141_18_93 1301100.HG529407_gene252 1.25e-130 380.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,36DC6@31979|Clostridiaceae 186801|Clostridia C phosphate butyryltransferase ptb1 - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB k141_18_96 1499689.CCNN01000013_gene3079 3.96e-150 442.0 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,36FRJ@31979|Clostridiaceae 186801|Clostridia J tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k141_18_97 1292035.H476_0634 5.46e-227 637.0 COG1757@1|root,COG1757@2|Bacteria,1TQPI@1239|Firmicutes,2495U@186801|Clostridia,25QPI@186804|Peptostreptococcaceae 186801|Clostridia C Na+/H+ antiporter family - - - - - - - - - - - - Na_H_antiporter k141_18_98 445972.ANACOL_02791 5.5e-10 55.8 COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WKG3@541000|Ruminococcaceae 186801|Clostridia C PFAM Rubredoxin-type Fe(Cys)4 protein rub - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Rubredoxin k141_18_99 1511.CLOST_1096 3.35e-92 274.0 COG4189@1|root,COG4189@2|Bacteria,1UHX2@1239|Firmicutes,25E60@186801|Clostridia,25UNM@186804|Peptostreptococcaceae 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_20 k141_18_100 1121324.CLIT_10c02880 6.84e-211 603.0 COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,25QMT@186804|Peptostreptococcaceae 186801|Clostridia FJ Phosphoribulokinase / Uridine kinase family udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK k141_18_101 1121324.CLIT_10c02890 3.08e-26 109.0 COG0648@1|root,COG0648@2|Bacteria,1UFG6@1239|Firmicutes,24FBC@186801|Clostridia,25RBT@186804|Peptostreptococcaceae 186801|Clostridia L Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k141_18_102 1121324.CLIT_10c02900 6.57e-76 232.0 COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia,25TG3@186804|Peptostreptococcaceae 186801|Clostridia U Signal peptidase, peptidase S26 lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 k141_18_103 1121324.CLIT_10c02910 4.8e-93 282.0 arCOG00127@1|root,33TE0@2|Bacteria,1VQPB@1239|Firmicutes,24ZZX@186801|Clostridia 186801|Clostridia C Tetratricopeptide repeat - - - - - - - - - - - - - k141_18_104 138119.DSY0745 0.000136 48.1 COG1559@1|root,COG1559@2|Bacteria,1VZ75@1239|Firmicutes,24UQ1@186801|Clostridia,2662J@186807|Peptococcaceae 186801|Clostridia S periplasmic solute-binding protein - - - - - - - - - - - - YceG k141_18_105 203120.LEUM_1797 3.04e-55 184.0 COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,4AX0S@81850|Leuconostocaceae 91061|Bacilli S Peptidase C26 puuD - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k141_18_106 931626.Awo_c17560 1.07e-129 383.0 COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,25V1R@186806|Eubacteriaceae 186801|Clostridia T Psort location Cytoplasmic, score - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,PAS_3,Response_reg k141_18_107 1121405.dsmv_2602 2.39e-143 488.0 COG0642@1|root,COG0715@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0715@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MITZ@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3 k141_18_108 42256.RradSPS_0680 4.54e-07 54.7 COG0517@1|root,COG0517@2|Bacteria,2HPZ3@201174|Actinobacteria,4CREF@84995|Rubrobacteria 84995|Rubrobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k141_18_111 1408423.JHYA01000007_gene175 3.58e-33 144.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H3BE@909932|Negativicutes 909932|Negativicutes NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_18_112 1232452.BAIB02000006_gene1020 2.75e-68 225.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,2687M@186813|unclassified Clostridiales 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k141_18_113 946235.CAER01000074_gene579 0.0 888.0 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,4HAZV@91061|Bacilli,23K3F@182709|Oceanobacillus 91061|Bacilli L Bacterial DNA topoisomeraes I ATP-binding domain - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k141_227_1 1321778.HMPREF1982_01729 1.58e-66 225.0 COG0477@1|root,COG2814@2|Bacteria,1TQDU@1239|Firmicutes,25ESY@186801|Clostridia 186801|Clostridia EGP Major Facilitator - - - - - - - - - - - - MFS_1 k141_227_2 1094466.KQS_12710 6.46e-59 193.0 COG0670@1|root,COG0670@2|Bacteria,4NG98@976|Bacteroidetes,1I1C3@117743|Flavobacteriia 976|Bacteroidetes S Inhibitor of apoptosis-promoting Bax1 ybhL - - ko:K06890 - - - - ko00000 - - - Bax1-I k141_227_3 997350.HMPREF9129_0057 2.37e-43 156.0 COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,249YF@186801|Clostridia 186801|Clostridia S NADP oxidoreductase coenzyme F420-dependent - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like k141_227_4 1151292.QEW_1921 5.02e-112 331.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k141_227_5 545697.HMPREF0216_00480 6.11e-88 271.0 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,36E8S@31979|Clostridiaceae 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k141_227_6 1291050.JAGE01000002_gene3440 2.64e-38 132.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,3WJM9@541000|Ruminococcaceae 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k141_227_7 1395513.P343_08435 4.46e-42 145.0 COG3981@1|root,COG3981@2|Bacteria,1V1C4@1239|Firmicutes,4HG6C@91061|Bacilli 91061|Bacilli K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 k141_227_11 1087481.AGFX01000018_gene1757 7.33e-140 442.0 COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,4IRFV@91061|Bacilli 91061|Bacilli S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k141_227_12 926692.AZYG01000054_gene2299 7.23e-18 92.8 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,3WB5H@53433|Halanaerobiales 186801|Clostridia NT Cache domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,sCache_2 k141_227_14 1294142.CINTURNW_1213 2.39e-63 213.0 COG0491@1|root,COG2119@1|root,COG0491@2|Bacteria,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,36HDQ@31979|Clostridiaceae 186801|Clostridia S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k141_227_15 315749.Bcer98_1389 2.87e-75 265.0 COG4652@1|root,COG4652@2|Bacteria,1V0A8@1239|Firmicutes,4HI0H@91061|Bacilli,1ZDTD@1386|Bacillus 91061|Bacilli S Protein of unknown function (DUF1430) - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - DUF1430 k141_227_16 1169144.KB910957_gene3880 2.14e-79 243.0 COG1136@1|root,COG1136@2|Bacteria,1V3NN@1239|Firmicutes,4HI0Q@91061|Bacilli,1ZGVP@1386|Bacillus 91061|Bacilli V ATPases associated with a variety of cellular activities - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k141_227_20 272563.CD630_33090 2.05e-277 783.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,25R5S@186804|Peptostreptococcaceae 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k141_227_24 1121342.AUCO01000009_gene363 1.26e-53 179.0 COG1994@1|root,COG1994@2|Bacteria,1TSA9@1239|Firmicutes,24CR6@186801|Clostridia,36GS8@31979|Clostridiaceae 186801|Clostridia S Peptidase family M50 - - - - - - - - - - - - - k141_234_1 1121324.CLIT_23c01310 1.34e-226 646.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,25S3J@186804|Peptostreptococcaceae 186801|Clostridia KT Bacterial regulatory protein, Fis family prdR - - - - - - - - - - - CBS,HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k141_234_2 941824.TCEL_00549 2.99e-26 105.0 COG3432@1|root,COG3432@2|Bacteria,1V75P@1239|Firmicutes,24JAZ@186801|Clostridia,36IRW@31979|Clostridiaceae 186801|Clostridia K Domain of unknown function (DUF4364) - - - - - - - - - - - - DUF4364 k141_234_3 1415775.U729_2922 7.63e-32 113.0 2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia,36MNV@31979|Clostridiaceae 186801|Clostridia S TSCPD domain - - - - - - - - - - - - TSCPD k141_234_4 1408823.AXUS01000016_gene1005 1.21e-150 441.0 COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,25QCF@186804|Peptostreptococcaceae 186801|Clostridia H Folylpolyglutamate synthase folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k141_124_41 796940.HMPREF9628_00463 1.52e-74 224.0 COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,25R98@186804|Peptostreptococcaceae 186801|Clostridia J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k141_124_42 1035196.HMPREF9998_00689 1.1e-62 194.0 COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,25T88@186804|Peptostreptococcaceae 186801|Clostridia J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k141_124_43 500633.CLOHIR_01600 5.15e-39 131.0 COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,25RSC@186804|Peptostreptococcaceae 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k141_124_44 1321778.HMPREF1982_00342 1.5e-19 83.6 COG2163@1|root,COG2163@2|Bacteria,1VEPA@1239|Firmicutes,24QMU@186801|Clostridia 186801|Clostridia J COG2163 Ribosomal protein L14E L6E L27E - - - - - - - - - - - - - k141_124_45 1286171.EAL2_c01790 1.02e-131 379.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,25V68@186806|Eubacteriaceae 186801|Clostridia E Psort location Cytoplasmic, score map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k141_124_46 1121289.JHVL01000024_gene141 5.55e-104 306.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,36ETU@31979|Clostridiaceae 186801|Clostridia F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS20110 ADK,ADK_lid k141_124_47 1511.CLOST_2178 1.47e-206 582.0 COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,25QD8@186804|Peptostreptococcaceae 186801|Clostridia U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k141_112_1 763034.HMPREF9446_00190 2.16e-17 87.0 COG1193@1|root,COG1193@2|Bacteria,4NNNV@976|Bacteroidetes,2FMM1@200643|Bacteroidia,4AMQQ@815|Bacteroidaceae 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF2027,Smr k141_174_1 1286171.EAL2_c01550 1.92e-181 512.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,25V5M@186806|Eubacteriaceae 186801|Clostridia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k141_185_3 1286171.EAL2_c22190 7.6e-128 383.0 COG0457@1|root,COG1396@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,1VHJ0@1239|Firmicutes,247R0@186801|Clostridia 186801|Clostridia K Helix-turn-helix domain protein - - - - - - - - - - - - HTH_19,HTH_3,TPR_12,TPR_8 k141_185_4 865861.AZSU01000006_gene1182 4.21e-67 216.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,36DTS@31979|Clostridiaceae 186801|Clostridia K Belongs to the ParB family spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k141_175_1 869213.JCM21142_73057 1.78e-67 211.0 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,47K8P@768503|Cytophagia 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k141_175_2 1168289.AJKI01000056_gene3067 4.02e-15 72.8 COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,2FN9G@200643|Bacteroidia,3XJSC@558415|Marinilabiliaceae 976|Bacteroidetes J RNA pseudouridylate synthase rluC - 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k141_157_1 1536769.P40081_07065 4.4e-18 87.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - PT-TG,TNT,Toxin-deaminase,WXG100 k141_8_1 709991.Odosp_0176 3.15e-101 322.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,4NF4F@976|Bacteroidetes,2FKZU@200643|Bacteroidia,22WF0@171551|Porphyromonadaceae 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k141_49_1 1205681.CALW02000073_gene1919 1.05e-15 68.9 2AIDV@1|root,318V9@2|Bacteria,1Q10S@1224|Proteobacteria,2V5CE@28211|Alphaproteobacteria,48UFJ@772|Bartonellaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k141_49_2 1408823.AXUS01000040_gene1666 2.31e-42 140.0 2DPII@1|root,3327T@2|Bacteria,1VHT9@1239|Firmicutes,24RHP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_160_1 927658.AJUM01000047_gene2889 2.49e-22 95.1 COG0550@1|root,COG0550@2|Bacteria,4NE6R@976|Bacteroidetes,2FN9D@200643|Bacteroidia,3XIN7@558415|Marinilabiliaceae 976|Bacteroidetes L Bacterial DNA topoisomeraes I ATP-binding domain topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim k141_160_2 985255.APHJ01000028_gene928 1.77e-14 75.1 COG0671@1|root,COG0671@2|Bacteria,4NNVQ@976|Bacteroidetes,1I2I3@117743|Flavobacteriia,2P6PQ@244698|Gillisia 976|Bacteroidetes I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k141_202_1 1280692.AUJL01000004_gene832 2.01e-38 146.0 COG3266@1|root,COG3266@2|Bacteria,1UNJR@1239|Firmicutes,25HET@186801|Clostridia,36VAC@31979|Clostridiaceae 186801|Clostridia S Siphovirus ReqiPepy6 Gp37-like protein - - - - - - - - - - - - Collagen,Sipho_Gp37 k141_202_3 634956.Geoth_0802 1.55e-13 64.7 295QT@1|root,2ZT24@2|Bacteria,1W3AA@1239|Firmicutes,4I08M@91061|Bacilli,1WHPP@129337|Geobacillus 91061|Bacilli - - - - - - - - - - - - - - - k141_202_4 411459.RUMOBE_01714 9.66e-48 158.0 COG4824@1|root,COG4824@2|Bacteria,1V934@1239|Firmicutes,24MXR@186801|Clostridia,3Y0R2@572511|Blautia 186801|Clostridia S Bacteriophage holin family - - - - - - - - - - - - Phage_holin_4_1 k141_51_1 1304284.L21TH_2353 2.97e-157 453.0 COG0416@1|root,COG0416@2|Bacteria,1TPY8@1239|Firmicutes,248BX@186801|Clostridia,36EUZ@31979|Clostridiaceae 186801|Clostridia I PFAM fatty acid synthesis plsX protein grdD - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K21576 - - - - ko00000,ko01000 - - - FA_synthesis k141_51_2 1304284.L21TH_2354 2.34e-278 771.0 COG0332@1|root,COG0332@2|Bacteria,1TQSB@1239|Firmicutes,2499C@186801|Clostridia,36FF2@31979|Clostridiaceae 186801|Clostridia I 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III grdC - 1.21.4.2,1.21.4.3,1.21.4.4 ko:K21577 - - - - ko00000,ko01000 - - - ACP_syn_III k141_80_1 272562.CA_C0250 2.54e-56 210.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 k141_80_2 1033737.CAEV01000065_gene2779 5.81e-47 157.0 COG4463@1|root,COG4463@2|Bacteria,1VAXT@1239|Firmicutes,24JH3@186801|Clostridia,36JKR@31979|Clostridiaceae 186801|Clostridia K Belongs to the CtsR family ctsR - - ko:K03708 - - - - ko00000,ko03000 - - - CtsR k141_80_3 1385512.N784_09470 5.93e-41 143.0 COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HH4R@91061|Bacilli,2YABU@289201|Pontibacillus 91061|Bacilli S UvrB/uvrC motif mcsA GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 - ko:K19411 - - - - ko00000 - - - UVR k141_80_4 1286171.EAL2_c01210 1.49e-152 439.0 COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia,25WRU@186806|Eubacteriaceae 186801|Clostridia E ATP:guanido phosphotransferase, C-terminal catalytic domain mcsB - 2.7.14.1 ko:K19405 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - ATP-gua_Ptrans k141_80_5 1121324.CLIT_24c01040 0.0 1119.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,25QH6@186804|Peptostreptococcaceae 186801|Clostridia O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k141_80_6 908338.HMPREF9286_0653 6.12e-12 65.1 2E3QR@1|root,32YNK@2|Bacteria,1VENX@1239|Firmicutes,24QVR@186801|Clostridia,22J14@1570339|Peptoniphilaceae 186801|Clostridia S Protein of unknown function (DUF1292) - - - - - - - - - - - - DUF1292 k141_80_7 1286171.EAL2_c18120 3.45e-61 193.0 COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,25WAC@186806|Eubacteriaceae 186801|Clostridia S SEC-C motif secA_2 - - - - - - - - - - - SEC-C k141_178_1 913865.DOT_6066 2.43e-23 98.2 COG3464@1|root,COG4584@1|root,COG3464@2|Bacteria,COG4584@2|Bacteria,1VE6P@1239|Firmicutes,24EJ6@186801|Clostridia 186801|Clostridia L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3 k141_178_2 748449.Halha_1482 8.26e-139 398.0 COG2801@1|root,COG2801@2|Bacteria,1TPEH@1239|Firmicutes,24DNX@186801|Clostridia,3WB69@53433|Halanaerobiales 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve k141_178_3 1121289.JHVL01000075_gene1050 4.91e-48 154.0 COG2963@1|root,COG2963@2|Bacteria,1V9ZX@1239|Firmicutes,24P3X@186801|Clostridia,36MBA@31979|Clostridiaceae 186801|Clostridia L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k141_230_1 35703.DQ02_18710 0.00097 46.6 2EFPB@1|root,32SG8@2|Bacteria,1N286@1224|Proteobacteria,1SAJ9@1236|Gammaproteobacteria,3WZGD@544|Citrobacter 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k141_230_2 398512.JQKC01000008_gene816 7.08e-109 337.0 COG3501@1|root,COG3501@2|Bacteria,1V043@1239|Firmicutes,248CZ@186801|Clostridia,3WNKD@541000|Ruminococcaceae 186801|Clostridia S Rhs element vgr protein gpP - - - - - - - - - - - Phage_GPD k141_230_3 1345695.CLSA_c31800 2.77e-16 81.6 COG1357@1|root,COG1357@2|Bacteria,1VNCI@1239|Firmicutes,24EAN@186801|Clostridia,36ECH@31979|Clostridiaceae 186801|Clostridia S PFAM Pentapeptide repeats (8 copies) - - - - - - - - - - - - - k141_230_5 1410653.JHVC01000008_gene3070 4.74e-33 121.0 2EE7B@1|root,3381W@2|Bacteria,1VAIC@1239|Firmicutes,24PS3@186801|Clostridia,36M8G@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF4280) - - - - - - - - - - - - DUF4280 k141_230_6 398512.JQKC01000010_gene179 2.73e-49 190.0 COG3501@1|root,COG3501@2|Bacteria,1TSS0@1239|Firmicutes,25BBM@186801|Clostridia 186801|Clostridia S Rhs element vgr protein - - - - - - - - - - - - Phage_GPD k141_86_1 203275.BFO_2581 6.45e-39 148.0 COG5585@1|root,COG5585@2|Bacteria 2|Bacteria - - - - - ko:K11044 - - - - ko00000,ko01000,ko02042 - - - ADPrib_exo_Tox,AHH,PT-TG k141_86_3 1517682.HW49_10205 1.73e-26 108.0 COG0457@1|root,COG0457@2|Bacteria,4NV0M@976|Bacteroidetes,2FUD1@200643|Bacteroidia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8 k141_182_2 867900.Celly_1458 0.0007 48.9 COG5492@1|root,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - - - - - - - - - - - Flg_new,LRR_5 k141_103_1 338963.Pcar_2784 1.21e-44 167.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MC0@68525|delta/epsilon subdivisions,2X5CV@28221|Deltaproteobacteria,43W2D@69541|Desulfuromonadales 68525|delta/epsilon subdivisions P ABC transporter - - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k141_103_2 1293054.HSACCH_00299 1.71e-68 221.0 COG1177@1|root,COG1177@2|Bacteria,1URBC@1239|Firmicutes,24801@186801|Clostridia,3WAZP@53433|Halanaerobiales 186801|Clostridia E Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k141_103_3 1301100.HG529399_gene6834 1.93e-51 177.0 COG1176@1|root,COG1176@2|Bacteria,1V1K7@1239|Firmicutes,24A4Q@186801|Clostridia,36GH7@31979|Clostridiaceae 186801|Clostridia P inner membrane component - - - ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k141_103_4 768710.DesyoDRAFT_2623 2.15e-140 414.0 COG4134@1|root,COG4134@2|Bacteria,1TR3G@1239|Firmicutes,24A5K@186801|Clostridia,2640Y@186807|Peptococcaceae 186801|Clostridia S Bacterial extracellular solute-binding protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8 k141_103_5 1476973.JMMB01000007_gene1668 1.55e-60 194.0 COG0558@1|root,COG0558@2|Bacteria,1V33A@1239|Firmicutes,24G6W@186801|Clostridia,25TDP@186804|Peptostreptococcaceae 186801|Clostridia I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf k141_103_6 555079.Toce_0088 2.77e-60 196.0 COG0398@1|root,COG0398@2|Bacteria,1UHVT@1239|Firmicutes,24H7Q@186801|Clostridia 186801|Clostridia S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k141_103_8 1150474.JQJI01000004_gene366 3.59e-27 124.0 COG2199@1|root,COG3706@2|Bacteria,2GCEU@200918|Thermotogae 200918|Thermotogae T PFAM GGDEF domain - - - - - - - - - - - - GGDEF k141_104_1 1131812.JQMS01000001_gene3267 3.37e-10 54.7 2DRUE@1|root,33D3X@2|Bacteria,4NYIB@976|Bacteroidetes,1IDB7@117743|Flavobacteriia,2NXXU@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k141_183_4 511680.BUTYVIB_00032 3.19e-64 206.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,4BXVM@830|Butyrivibrio 186801|Clostridia T Transcriptional regulatory protein, C terminal srrA_6 - - - - - - - - - - - Response_reg,Trans_reg_C k141_183_5 332101.JIBU02000009_gene763 1.01e-81 273.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DKF@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_66_1 1347086.CCBA010000030_gene225 3.26e-09 55.1 COG1943@1|root,COG1943@2|Bacteria,1V3YY@1239|Firmicutes,4HJZJ@91061|Bacilli,1ZQX1@1386|Bacillus 91061|Bacilli L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k141_184_53 190304.FN1552 5.73e-64 211.0 2A9ZF@1|root,30Z7W@2|Bacteria 2|Bacteria S RloB-like protein - - - - - - - - - - - - RloB k141_184_54 190304.FN1553 2.39e-177 511.0 COG1106@1|root,COG1106@2|Bacteria,379FD@32066|Fusobacteria 32066|Fusobacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K06926 - - - - ko00000 - - - AAA_21 k141_203_3 1033737.CAEV01000039_gene2086 1.65e-205 599.0 COG2309@1|root,COG2309@2|Bacteria,1TSPE@1239|Firmicutes,24A6S@186801|Clostridia,36DC3@31979|Clostridiaceae 186801|Clostridia E Thermophilic metalloprotease (M29) - - - - - - - - - - - - Peptidase_M29 k141_203_7 86416.Clopa_4624 1.12e-109 324.0 COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia,36E5T@31979|Clostridiaceae 186801|Clostridia E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k141_203_8 1347392.CCEZ01000049_gene1637 0.0 1175.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae 186801|Clostridia C Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k141_203_9 457570.Nther_2477 3.12e-74 237.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia 186801|Clostridia C glycyl-radical enzyme activating protein family csdA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM k141_203_10 1301100.HG529332_gene4571 3.56e-69 215.0 COG1396@1|root,COG3837@1|root,COG1396@2|Bacteria,COG3837@2|Bacteria,1V3VT@1239|Firmicutes,25EB4@186801|Clostridia,36W73@31979|Clostridiaceae 186801|Clostridia K Cupin domain - - - - - - - - - - - - Cupin_2,HTH_3 k141_203_12 935836.JAEL01000008_gene3945 8.99e-67 209.0 COG1896@1|root,COG1896@2|Bacteria,1V7E8@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score 8.87 - - - ko:K06952 - - - - ko00000 - - - DUF429,HD_3 k141_203_13 1487921.DP68_00935 1.25e-98 303.0 COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia,36EU8@31979|Clostridiaceae 186801|Clostridia S tRNA-splicing ligase RtcB - - 6.5.1.3 ko:K14415,ko:K18148 ko01501,map01501 - - - ko00000,ko00001,ko01000,ko03016 - - - RtcB k141_203_14 1385513.N780_15530 7.11e-64 209.0 COG3153@1|root,COG3153@2|Bacteria 2|Bacteria S transferase activity, transferring acyl groups - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_9 k141_203_15 1304284.L21TH_1966 4.83e-126 379.0 2F0NN@1|root,33TR4@2|Bacteria,1VSJ0@1239|Firmicutes,24ZWE@186801|Clostridia,36R0M@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_203_16 293826.Amet_0108 6.62e-71 218.0 COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,24NF2@186801|Clostridia,36KPM@31979|Clostridiaceae 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k141_203_21 1230342.CTM_15038 5.73e-100 304.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1TQX3@1239|Firmicutes,24A3W@186801|Clostridia,36FUZ@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k141_203_22 926561.KB900621_gene2825 1.32e-144 430.0 COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,3WAHJ@53433|Halanaerobiales 186801|Clostridia L PFAM DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase k141_203_23 1123355.JHYO01000005_gene846 2.12e-50 201.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,36XKH@31993|Methylocystaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k141_165_2 397288.C806_03780 3.72e-41 152.0 COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,27J4B@186928|unclassified Lachnospiraceae 186801|Clostridia E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS11970 HTS k141_165_3 1121324.CLIT_23c02390 2.92e-178 511.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,25QKY@186804|Peptostreptococcaceae 186801|Clostridia E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k141_165_4 931626.Awo_c02820 3.75e-77 251.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,25V9Z@186806|Eubacteriaceae 186801|Clostridia E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k141_165_5 1231057.AMGD01000017_gene1345 2.23e-64 219.0 COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,4HBAP@91061|Bacilli,26DDX@186818|Planococcaceae 91061|Bacilli E Homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS06610 ACT,Homoserine_dh,NAD_binding_3 k141_165_6 469616.FMAG_00747 1.02e-83 260.0 COG0685@1|root,COG0685@2|Bacteria,3787V@32066|Fusobacteria 32066|Fusobacteria C Psort location Cytoplasmic, score metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k141_165_7 1160721.RBI_I01350 2.77e-30 118.0 COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,3WJ7R@541000|Ruminococcaceae 186801|Clostridia E Vitamin B12 dependent methionine synthase activation metH2 - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Met_synt_B12 k141_165_8 1443122.Z958_02965 6.07e-133 378.0 COG2452@1|root,COG2452@2|Bacteria,1TQNJ@1239|Firmicutes,24B79@186801|Clostridia,36GX6@31979|Clostridiaceae 186801|Clostridia L MerR HTH family regulatory protein - - - ko:K07450 - - - - ko00000 - - - MerR,MerR_1,Resolvase k141_165_9 1410653.JHVC01000014_gene3383 4.17e-185 525.0 COG0675@1|root,COG0675@2|Bacteria,1TRNY@1239|Firmicutes,247T1@186801|Clostridia,36E4A@31979|Clostridiaceae 186801|Clostridia L Transposase - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon k141_165_10 545697.HMPREF0216_02149 2.81e-255 735.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae 186801|Clostridia E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k141_165_11 521045.Kole_1675 2.41e-21 97.8 COG5061@1|root,COG5061@2|Bacteria,2GDZC@200918|Thermotogae 200918|Thermotogae OU Protein of unknown function (DUF3307) - - - - - - - - - - - - DUF3307 k141_165_13 240302.BN982_01688 4.45e-17 80.5 COG1670@1|root,COG1670@2|Bacteria,1V7SS@1239|Firmicutes,4HJGC@91061|Bacilli 91061|Bacilli J COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_3 k141_167_1 1160707.AJIK01000046_gene1661 7.33e-115 345.0 COG3464@1|root,COG3464@2|Bacteria,1TQ93@1239|Firmicutes,4HC0Q@91061|Bacilli,26HF2@186818|Planococcaceae 91061|Bacilli L Transposase - - - ko:K07485 - - - - ko00000 - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k141_149_1 398512.JQKC01000010_gene179 4.16e-49 177.0 COG3501@1|root,COG3501@2|Bacteria,1TSS0@1239|Firmicutes,25BBM@186801|Clostridia 186801|Clostridia S Rhs element vgr protein - - - - - - - - - - - - Phage_GPD k141_149_2 1122921.KB898188_gene5 7.86e-22 95.1 2EE7B@1|root,3381W@2|Bacteria,1VAIC@1239|Firmicutes,4I80S@91061|Bacilli,26YGS@186822|Paenibacillaceae 91061|Bacilli S Domain of unknown function (DUF4280) - - - - - - - - - - - - DUF4280 k141_149_6 1410653.JHVC01000008_gene3074 1.32e-42 149.0 2EFPB@1|root,339FB@2|Bacteria,1V5BB@1239|Firmicutes,24BIN@186801|Clostridia,36HDD@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_149_7 1345695.CLSA_c08120 1.43e-53 181.0 28N3U@1|root,2ZB9G@2|Bacteria,1V09T@1239|Firmicutes,2493C@186801|Clostridia,36GU6@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_149_8 1196322.A370_05277 1.13e-168 520.0 COG0443@1|root,COG0443@2|Bacteria,1TT0Z@1239|Firmicutes,24AG5@186801|Clostridia,36EUB@31979|Clostridiaceae 186801|Clostridia O Heat shock 70 kDa protein - - - - - - - - - - - - - k141_149_9 641107.CDLVIII_1217 2.59e-63 204.0 28N97@1|root,2ZBD9@2|Bacteria,1UYY7@1239|Firmicutes,24MD6@186801|Clostridia,36GUV@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_149_10 641107.CDLVIII_1216 4.48e-83 268.0 28ISJ@1|root,2Z8RQ@2|Bacteria,1TRGC@1239|Firmicutes,24CC6@186801|Clostridia,36EES@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_149_11 1410653.JHVC01000008_gene3080 1.14e-112 354.0 COG0631@1|root,COG0631@2|Bacteria,1TQWN@1239|Firmicutes,247KV@186801|Clostridia,36F98@31979|Clostridiaceae 186801|Clostridia T Serine/threonine phosphatases, family 2C, catalytic domain - - - - - - - - - - - - SpoIIE k141_149_12 1449050.JNLE01000003_gene1186 1.54e-54 185.0 COG0631@1|root,COG0631@2|Bacteria,1V094@1239|Firmicutes,24N9G@186801|Clostridia,36F42@31979|Clostridiaceae 186801|Clostridia T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2,SpoIIE k141_149_13 1415774.U728_285 3.24e-82 247.0 COG1716@1|root,COG1716@2|Bacteria,1UZ57@1239|Firmicutes,24PC6@186801|Clostridia,36GM9@31979|Clostridiaceae 186801|Clostridia T FHA domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k141_149_14 397291.C804_06508 7.95e-25 102.0 COG1716@1|root,COG1716@2|Bacteria,1VFJ4@1239|Firmicutes,24Q0H@186801|Clostridia,27PDZ@186928|unclassified Lachnospiraceae 186801|Clostridia T Forkhead associated domain - - - - - - - - - - - - FHA k141_149_15 1163389.OOM_0477 5.82e-15 78.2 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,45ZTV@72273|Thiotrichales 72273|Thiotrichales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k141_149_16 290402.Cbei_4405 2.73e-72 219.0 2AGPY@1|root,316XK@2|Bacteria,1V8P2@1239|Firmicutes,25DTK@186801|Clostridia,36I5F@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_149_17 1410653.JHVC01000008_gene3086 5.75e-74 224.0 2AGPY@1|root,316XK@2|Bacteria,1V241@1239|Firmicutes,25DTM@186801|Clostridia,36I8A@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_149_18 1410653.JHVC01000008_gene3087 0.0 1050.0 2C1IS@1|root,2Z86T@2|Bacteria,1TQRA@1239|Firmicutes,247QX@186801|Clostridia,36FTF@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_149_21 318464.IO99_04310 1.21e-193 541.0 28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,247QF@186801|Clostridia,36EPD@31979|Clostridiaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k141_149_22 1120998.AUFC01000001_gene1735 1.18e-109 335.0 COG3325@1|root,COG3858@1|root,COG3325@2|Bacteria,COG3858@2|Bacteria,1VF50@1239|Firmicutes,24KR5@186801|Clostridia 186801|Clostridia G Glyco_18 - - - - - - - - - - - - Cu_amine_oxidN1,Glyco_hydro_18 k141_149_24 1511.CLOST_1664 7.11e-125 366.0 COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,25QUN@186804|Peptostreptococcaceae 186801|Clostridia S radical SAM protein, TIGR01212 family ytqA - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k141_149_25 1121324.CLIT_23c04960 6.74e-247 689.0 COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,25QVH@186804|Peptostreptococcaceae 186801|Clostridia F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k141_149_28 1005048.CFU_0008 4.45e-188 541.0 COG3344@1|root,COG3344@2|Bacteria,1R83H@1224|Proteobacteria 1224|Proteobacteria L RNA-directed DNA polymerase - - - - - - - - - - - - RVT_1 k141_149_29 37659.JNLN01000001_gene1338 1.43e-102 308.0 COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,24AQ8@186801|Clostridia,36GMQ@31979|Clostridiaceae 186801|Clostridia G Aldose 1-epimerase lacX - - - - - - - - - - - Aldose_epim k141_149_30 1347392.CCEZ01000020_gene940 2.34e-41 137.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,36KID@31979|Clostridiaceae 186801|Clostridia L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k141_149_31 293826.Amet_2653 4.48e-173 495.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae 186801|Clostridia E Aminotransferase aspC - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k141_149_32 1128398.Curi_c25510 9.52e-260 720.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,26AMQ@186813|unclassified Clostridiales 186801|Clostridia H Aminotransferase class-III bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k141_149_33 1476973.JMMB01000007_gene482 7.4e-80 246.0 COG0132@1|root,COG0132@2|Bacteria,1UYA3@1239|Firmicutes,24F15@186801|Clostridia 186801|Clostridia H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k141_149_34 469617.FUAG_00243 1.14e-45 153.0 COG1846@1|root,COG1846@2|Bacteria,37B0X@32066|Fusobacteria 32066|Fusobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k141_149_35 1476973.JMMB01000007_gene1614 1.23e-134 394.0 COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia,25QGA@186804|Peptostreptococcaceae 186801|Clostridia E Beta-eliminating lyase ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k141_149_36 1121324.CLIT_10c01470 9.23e-72 222.0 COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia 186801|Clostridia S PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD k141_149_37 573061.Clocel_4333 2.86e-88 275.0 COG1816@1|root,COG1816@2|Bacteria,1U44B@1239|Firmicutes,247KD@186801|Clostridia,36F6X@31979|Clostridiaceae 186801|Clostridia F adenosine deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS13960 A_deaminase k141_39_66 1408439.JHXW01000001_gene1882 3.86e-05 51.6 COG0454@1|root,COG0456@2|Bacteria,37AQU@32066|Fusobacteria 32066|Fusobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_7 k141_39_68 1121324.CLIT_10c04250 8.17e-153 442.0 COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia 186801|Clostridia V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k141_39_69 1121324.CLIT_10c04240 6.52e-103 307.0 COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia 186801|Clostridia V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_39_70 1121324.CLIT_10c04230 3.99e-77 246.0 COG1566@1|root,COG1566@2|Bacteria,1UJ4C@1239|Firmicutes,25EVQ@186801|Clostridia 186801|Clostridia V Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP k141_39_71 1121324.CLIT_2c03720 1.68e-105 310.0 COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia 186801|Clostridia S channel protein, hemolysin III family - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k141_39_72 1033737.CAEV01000025_gene372 7.25e-60 199.0 COG1284@1|root,COG1284@2|Bacteria,1TRAU@1239|Firmicutes,249DE@186801|Clostridia,36EK0@31979|Clostridiaceae 186801|Clostridia S hmm pf02588 - - - - - - - - - - - - DUF2179,YitT_membrane k141_39_73 1565129.JSFF01000033_gene1462 8.23e-36 151.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2Q8RK@267890|Shewanellaceae 1236|Gammaproteobacteria NT PFAM histidine kinase, HAMP region domain protein - - - ko:K03406,ko:K10937 ko02020,ko02030,ko05111,map02020,map02030,map05111 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k141_39_74 536232.CLM_1456 7.58e-86 285.0 COG5298@1|root,COG5298@2|Bacteria,1TSDC@1239|Firmicutes,25E03@186801|Clostridia,36FPX@31979|Clostridiaceae 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2334) - - - - - - - - - - - - DUF2334 k141_39_75 1122917.KB899663_gene2739 5.74e-148 449.0 COG5448@1|root,COG5448@2|Bacteria,1VUWS@1239|Firmicutes,4HVU6@91061|Bacilli 91061|Bacilli S Glycoside hydrolase family 24 - - - - - - - - - - - - - k141_39_76 1033737.CAEV01000092_gene1949 5.44e-71 218.0 COG3542@1|root,COG3542@2|Bacteria,1V52Y@1239|Firmicutes,24GKZ@186801|Clostridia,36I2M@31979|Clostridiaceae 186801|Clostridia S Cupin superfamily (DUF985) - - - ko:K09705 - - - - ko00000 - - - Cupin_5 k141_39_77 37659.JNLN01000001_gene1280 1.03e-14 86.7 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EVU@31979|Clostridiaceae 186801|Clostridia NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k141_39_78 1541959.KQ51_01293 2.35e-19 91.3 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k141_39_79 445335.CBN_3660 5.24e-87 268.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36F0C@31979|Clostridiaceae 186801|Clostridia O radical SAM domain protein yjjW - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Fer4_6,Radical_SAM k141_39_80 857293.CAAU_0062 1.48e-224 634.0 COG1328@1|root,COG1328@2|Bacteria,1TPAC@1239|Firmicutes,24A2W@186801|Clostridia,36GU2@31979|Clostridiaceae 186801|Clostridia F Protein of unknown function (DUF3029) yjjI - - - - - - - - - - - DUF3029 k141_39_81 1410653.JHVC01000006_gene32 1.23e-34 144.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36J4H@31979|Clostridiaceae 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k141_39_82 1347086.CCBA010000007_gene4530 1.77e-66 217.0 COG0697@1|root,COG0697@2|Bacteria,1TYSF@1239|Firmicutes,4HE6Y@91061|Bacilli,1ZQ37@1386|Bacillus 91061|Bacilli EG EamA-like transporter family ycxC - - - - - - - - - - - EamA k141_39_83 445335.CBN_1315 2.36e-74 228.0 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V1K5@1239|Firmicutes,24FTC@186801|Clostridia,36F4A@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator puuR - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 k141_39_84 1121335.Clst_1721 4.1e-10 72.8 COG0840@1|root,COG0840@2|Bacteria,1UZ0J@1239|Firmicutes,24F2H@186801|Clostridia 186801|Clostridia NT Chemotaxis pilJ - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k141_39_85 1487921.DP68_14360 7.75e-174 494.0 COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,25CCC@186801|Clostridia,36WTC@31979|Clostridiaceae 186801|Clostridia E Creatinase/Prolidase N-terminal domain pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k141_39_86 1243664.CAVL020000032_gene2872 4.72e-53 174.0 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V88H@1239|Firmicutes,4HMXE@91061|Bacilli,1ZCZV@1386|Bacillus 91061|Bacilli K Cupin domain - - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 k141_39_87 935845.JADQ01000047_gene2486 1.7e-114 346.0 COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,4HBDM@91061|Bacilli,26T54@186822|Paenibacillaceae 91061|Bacilli G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10544 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - BPD_transp_2 k141_39_88 697281.Mahau_2368 4.24e-214 608.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,42ESS@68295|Thermoanaerobacterales 186801|Clostridia P Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system xylG - 3.6.3.17 ko:K10441,ko:K10545 ko02010,map02010 M00212,M00215 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4 - - ABC_tran k141_39_89 1380408.AVGH01000047_gene2744 1.36e-135 397.0 COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,4HCK3@91061|Bacilli,21UZ3@150247|Anoxybacillus 91061|Bacilli G Periplasmic binding protein domain - - - ko:K02058,ko:K10543 ko02010,map02010 M00215,M00221 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.4 - - Peripla_BP_4 k141_39_90 935837.JAEK01000013_gene4933 1.13e-54 188.0 COG1940@1|root,COG1940@2|Bacteria,1UTWA@1239|Firmicutes,4I34V@91061|Bacilli,1ZMMM@1386|Bacillus 91061|Bacilli GK ROK family - - - - - - - - - - - - ROK k141_39_92 572479.Hprae_2073 4.3e-35 138.0 COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,25AZS@186801|Clostridia,3WCAA@53433|Halanaerobiales 186801|Clostridia T HD domain - - - - - - - - - - - - HD,HD_5 k141_39_93 1122925.KB895391_gene1524 1.05e-24 110.0 COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,4HBV6@91061|Bacilli,26RX7@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - - - - - - - - - - - HD,HD_5 k141_39_95 1123226.KB899287_gene3594 1.36e-59 194.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,4HE90@91061|Bacilli,26RVQ@186822|Paenibacillaceae 91061|Bacilli T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cseB - - - - - - - - - - - Response_reg,Trans_reg_C k141_39_96 386415.NT01CX_0613 3.38e-65 205.0 COG1954@1|root,COG1954@2|Bacteria,1V4IE@1239|Firmicutes,24HDM@186801|Clostridia,36I0D@31979|Clostridiaceae 186801|Clostridia K glycerol-3-phosphate responsive antiterminator glpP - - ko:K02443 - - - - ko00000,ko03000 - - - G3P_antiterm k141_39_97 1209989.TepiRe1_0622 1.05e-47 156.0 2DMKJ@1|root,32S74@2|Bacteria,1VC4F@1239|Firmicutes,24SDE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_39_98 883081.HMPREF9698_00635 1.61e-23 94.4 2DMS0@1|root,32T9Q@2|Bacteria,1VCJ5@1239|Firmicutes,4HN6D@91061|Bacilli,27GUS@186828|Carnobacteriaceae 91061|Bacilli - - - - - - - - - - - - - - - k141_39_99 1121289.JHVL01000017_gene763 4.23e-299 823.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,36EMF@31979|Clostridiaceae 186801|Clostridia F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k141_39_100 1121289.JHVL01000017_gene764 1.01e-222 628.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,36DNW@31979|Clostridiaceae 186801|Clostridia C FAD dependent oxidoreductase glpA - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD k141_39_101 1347392.CCEZ01000007_gene1959 3.09e-205 578.0 COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,36DSF@31979|Clostridiaceae 186801|Clostridia C Oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 k141_39_102 1235790.C805_02469 1.08e-33 120.0 COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,25WVW@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF1667) - - - - - - - - - - - - DUF1667 k141_39_103 641107.CDLVIII_4238 1.2e-99 320.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - PAS,PAS_9,PTS-HPr,Sigma54_activat k141_39_104 1121324.CLIT_12c00150 1.02e-124 371.0 COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,25RD8@186804|Peptostreptococcaceae 186801|Clostridia M Monogalactosyldiacylglycerol synthase - - 2.4.1.315 ko:K03429 ko00561,ko01100,map00561,map01100 - R02689,R04377 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT28 - Glyco_tran_28_C,MGDG_synth k141_39_105 1121324.CLIT_12c00140 1.75e-122 363.0 COG0392@1|root,COG0392@2|Bacteria,1TXG8@1239|Firmicutes,24A1A@186801|Clostridia,25UJG@186804|Peptostreptococcaceae 186801|Clostridia I Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k141_39_106 1121324.CLIT_10c02400 1.57e-49 180.0 COG5002@1|root,COG5002@2|Bacteria,1TPVJ@1239|Firmicutes,2489X@186801|Clostridia 186801|Clostridia T Histidine kinase- DNA gyrase B - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_39_107 536227.CcarbDRAFT_4064 1.43e-62 202.0 COG0745@1|root,COG0745@2|Bacteria,1TRS2@1239|Firmicutes,24AF1@186801|Clostridia,36GSN@31979|Clostridiaceae 186801|Clostridia T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain gtcR - - - - - - - - - - - Response_reg,Trans_reg_C k141_39_108 411459.RUMOBE_02065 2.87e-08 50.8 2AQUU@1|root,31G2Z@2|Bacteria,1UDXX@1239|Firmicutes,25IS7@186801|Clostridia,3Y251@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - k141_39_109 1033733.CAEK01000001_gene217 6.56e-88 270.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,22GGE@1570339|Peptoniphilaceae 186801|Clostridia C 4Fe-4S binding domain protein - - - - - - - - - - - - Fer4,Fer4_5 k141_39_110 645991.Sgly_2241 4.94e-48 160.0 COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,2624W@186807|Peptococcaceae 186801|Clostridia F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k141_39_111 1444309.JAQG01000004_gene3590 6.02e-05 54.7 COG3858@1|root,COG3858@2|Bacteria,1UJQT@1239|Firmicutes,4ITDF@91061|Bacilli,277D3@186822|Paenibacillaceae 91061|Bacilli S S-layer homology domain - - - - - - - - - - - - PepSY,SLH k141_39_112 1211817.CCAT010000062_gene3943 7.35e-196 556.0 COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,36DY4@31979|Clostridiaceae 186801|Clostridia S Permease - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k141_39_113 1121324.CLIT_10c00930 7.03e-76 240.0 COG0778@1|root,COG0778@2|Bacteria,1V297@1239|Firmicutes,24FWY@186801|Clostridia,25UIE@186804|Peptostreptococcaceae 186801|Clostridia C Putative TM nitroreductase - - - - - - - - - - - - TM1586_NiRdase k141_39_114 941824.TCEL_00112 5.69e-60 221.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,sCache_3_2 k141_242_135 1121324.CLIT_11c02470 9.47e-191 537.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,25QH2@186804|Peptostreptococcaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k141_242_136 445973.CLOBAR_02146 1.31e-228 646.0 COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,25R0R@186804|Peptostreptococcaceae 186801|Clostridia S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k141_124_48 1511.CLOST_2179 3.35e-74 225.0 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,25RKE@186804|Peptostreptococcaceae 186801|Clostridia J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k141_124_49 1408422.JHYF01000014_gene287 1.42e-18 77.8 COG1841@1|root,COG1841@2|Bacteria 2|Bacteria J maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k141_124_50 1476973.JMMB01000007_gene138 2.36e-93 275.0 COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,25RBS@186804|Peptostreptococcaceae 186801|Clostridia J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k141_124_51 997346.HMPREF9374_2862 2.2e-53 170.0 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,27C1D@186824|Thermoactinomycetaceae 91061|Bacilli J Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k141_124_52 1121324.CLIT_24c00520 9.13e-103 300.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k141_124_53 500633.CLOHIR_01591 1.13e-78 235.0 COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,25RBC@186804|Peptostreptococcaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k141_124_54 1121115.AXVN01000046_gene2971 4.67e-34 117.0 COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,24QR1@186801|Clostridia,3Y0DU@572511|Blautia 186801|Clostridia J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k141_124_55 864565.HMPREF0379_1899 4.23e-95 280.0 COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,25R4D@186804|Peptostreptococcaceae 186801|Clostridia J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k141_124_56 1291050.JAGE01000001_gene2103 4.4e-35 123.0 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,3WJBH@541000|Ruminococcaceae 186801|Clostridia J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k141_124_57 1408823.AXUS01000017_gene1125 2.54e-68 208.0 COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,25RF9@186804|Peptostreptococcaceae 186801|Clostridia J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k141_124_58 500633.CLOHIR_01586 8.81e-44 143.0 COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,25RSK@186804|Peptostreptococcaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k141_124_59 596330.HMPREF0628_0300 1.15e-22 89.0 COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,22HW8@1570339|Peptoniphilaceae 186801|Clostridia J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k141_124_60 350688.Clos_0499 8.34e-82 244.0 COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,36E4K@31979|Clostridiaceae 186801|Clostridia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k141_124_61 1511.CLOST_2192 3.03e-113 332.0 COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,25QNG@186804|Peptostreptococcaceae 186801|Clostridia J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k141_124_62 350688.Clos_0497 3.18e-45 149.0 COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,36JMN@31979|Clostridiaceae 186801|Clostridia J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k141_124_63 1286171.EAL2_c01610 1.3e-52 166.0 COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,25WMJ@186806|Eubacteriaceae 186801|Clostridia J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k141_124_64 445973.CLOBAR_00097 1.65e-153 436.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,25R5V@186804|Peptostreptococcaceae 186801|Clostridia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k141_124_65 1408422.JHYF01000014_gene302 1.49e-41 138.0 COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia,36JH0@31979|Clostridiaceae 186801|Clostridia J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k141_124_66 350688.Clos_0493 2.34e-100 296.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,36DFP@31979|Clostridiaceae 186801|Clostridia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k141_124_67 1286171.EAL2_c01570 8.85e-104 305.0 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,25VIA@186806|Eubacteriaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k141_124_68 1033743.CAES01000111_gene1459 6.43e-53 168.0 COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,4HIKH@91061|Bacilli,26XCR@186822|Paenibacillaceae 91061|Bacilli J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k141_124_69 525919.Apre_0638 7.27e-44 166.0 COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,22G4T@1570339|Peptoniphilaceae 186801|Clostridia M Bacterial capsule synthesis protein capA - - ko:K07282 - - - - ko00000 - - - PGA_cap k141_124_72 1267580.AF6_2688 3.17e-12 61.6 COG4317@1|root,COG4317@2|Bacteria,1VKJ6@1239|Firmicutes,4HR5W@91061|Bacilli,21X82@150247|Anoxybacillus 91061|Bacilli S Protein of unknown function (DUF1427) - - - - - - - - - - - - DUF1427 k141_124_73 445973.CLOBAR_01508 1.77e-69 211.0 COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,24J94@186801|Clostridia,25RFW@186804|Peptostreptococcaceae 186801|Clostridia E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k141_124_75 293826.Amet_1575 4.5e-98 322.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae 186801|Clostridia NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,HAMP,MCPsignal,dCache_1 k141_124_76 1121324.CLIT_14c00060 4.63e-221 648.0 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia 186801|Clostridia L helicase - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII k141_124_77 86416.Clopa_3880 4.38e-54 172.0 COG0537@1|root,COG0537@2|Bacteria,1V5CH@1239|Firmicutes,25CUE@186801|Clostridia 186801|Clostridia FG Scavenger mRNA decapping enzyme C-term binding - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT k141_124_78 386415.NT01CX_0322 1.23e-06 50.4 COG4997@1|root,COG4997@2|Bacteria,1VEG6@1239|Firmicutes,24QRF@186801|Clostridia,36KRV@31979|Clostridiaceae 186801|Clostridia S phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - DUF429,MazG-like k141_124_79 1121324.CLIT_14c00060 0.0 897.0 COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia 186801|Clostridia L helicase - - - - - - - - - - - - Helicase_C,PLDc_2,ResIII k141_209_2 1286171.EAL2_c04110 1.05e-41 145.0 COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,25WW2@186806|Eubacteriaceae 186801|Clostridia H 5-formyltetrahydrofolate cyclo-ligase yqgN - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k141_209_3 1121324.CLIT_13c01610 5.05e-108 317.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia 186801|Clostridia D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k141_209_4 1286171.EAL2_c04130 1.87e-105 316.0 COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,25VJS@186806|Eubacteriaceae 186801|Clostridia D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k141_209_5 588581.Cpap_0118 1.69e-34 135.0 COG4942@1|root,COG4942@2|Bacteria,1VJ3D@1239|Firmicutes,25ERZ@186801|Clostridia,3WSIV@541000|Ruminococcaceae 186801|Clostridia D Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k141_209_6 1121324.CLIT_13c01640 2.45e-151 439.0 COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,25QD4@186804|Peptostreptococcaceae 186801|Clostridia M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k141_209_7 1499689.CCNN01000007_gene1137 8.35e-267 746.0 COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia,36ET0@31979|Clostridiaceae 186801|Clostridia E oligoendopeptidase, M3 family pz-A - - - - - - - - - - - Peptidase_M3 k141_209_8 273068.TTE1096 9.58e-91 278.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,42FWZ@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S binding domain - - - ko:K02574 - - - - ko00000 - - - Fer4,Fer4_4,Fer4_5 k141_209_10 555079.Toce_0777 5.81e-72 228.0 COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,42G5C@68295|Thermoanaerobacterales 186801|Clostridia P Formate nitrite family of fdhC - - ko:K21993 - - - - ko00000,ko02000 1.A.16.2 - - Form_Nir_trans k141_209_11 865861.AZSU01000001_gene216 1.49e-112 335.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,36DWB@31979|Clostridiaceae 186801|Clostridia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k141_209_12 1408823.AXUS01000026_gene1552 2.83e-98 293.0 COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,24CMU@186801|Clostridia,25QY2@186804|Peptostreptococcaceae 186801|Clostridia E DNA polymerase alpha chain like domain - - - ko:K04477 - - - - ko00000 - - - PHP k141_209_13 596329.HMPREF0631_0474 1.02e-118 349.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,25QN8@186804|Peptostreptococcaceae 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k141_209_14 1286171.EAL2_c04510 2.77e-117 348.0 COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,248G0@186801|Clostridia,25VIG@186806|Eubacteriaceae 186801|Clostridia S Required for morphogenesis under gluconeogenic growth conditions - - - - - - - - - - - - UPF0052 k141_209_15 1511.CLOST_1655 4.21e-67 206.0 COG1051@1|root,COG1051@2|Bacteria,1V4E6@1239|Firmicutes,24HPT@186801|Clostridia,25REQ@186804|Peptostreptococcaceae 186801|Clostridia F Belongs to the Nudix hydrolase family apfA - - - - - - - - - - - NUDIX k141_209_16 1121324.CLIT_13c02020 2.93e-134 391.0 COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,25QUI@186804|Peptostreptococcaceae 186801|Clostridia K May be required for sporulation whiA - - ko:K09762 - - - - ko00000 - - - HTH_WhiA,LAGLIDADG_WhiA,WhiA_N k141_209_17 754477.Q7C_1700 1.56e-19 82.4 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,461HK@72273|Thiotrichales 72273|Thiotrichales G TIGRFAM Phosphotransferase System HPr (HPr) Family - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k141_209_18 338963.Pcar_2035 4.02e-96 298.0 COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria,43U4C@69541|Desulfuromonadales 28221|Deltaproteobacteria H Domain of unknown function (DUF3524) - - - - - - - - - - - - DUF3524,Glycos_transf_1 k141_209_19 1476973.JMMB01000007_gene3162 0.0 1523.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,25QW9@186804|Peptostreptococcaceae 186801|Clostridia L DNA polymerase dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k141_209_20 293826.Amet_4069 1.62e-158 452.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,36DGA@31979|Clostridiaceae 186801|Clostridia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k141_209_21 500633.CLOHIR_00682 3.96e-262 736.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,25QHI@186804|Peptostreptococcaceae 186801|Clostridia G Pyruvate kinase pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k141_209_22 1121324.CLIT_13c02090 0.0 879.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,25R6V@186804|Peptostreptococcaceae 186801|Clostridia U Sodium:neurotransmitter symporter family - - - - - - - - - - - - SNF k141_209_24 1121324.CLIT_13c02110 6.82e-61 197.0 29NU7@1|root,309SB@2|Bacteria,1V68J@1239|Firmicutes,24HMM@186801|Clostridia,25RMF@186804|Peptostreptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_209_25 1540257.JQMW01000009_gene2805 0.000863 47.0 COG1309@1|root,COG1309@2|Bacteria,1TSFG@1239|Firmicutes,24AME@186801|Clostridia,36HDI@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k141_209_26 1121324.CLIT_10c05120 6.43e-74 241.0 COG0845@1|root,COG0845@2|Bacteria,1V682@1239|Firmicutes,25887@186801|Clostridia,25U8H@186804|Peptostreptococcaceae 186801|Clostridia M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k141_209_27 1121324.CLIT_10c05110 0.0 1046.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,25QT4@186804|Peptostreptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG2 - - - - - - - - - - - ACR_tran k141_209_28 290402.Cbei_2083 1.17e-149 443.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36G1G@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K18907 - M00700,M00702 - - ko00000,ko00002,ko01504,ko03000 - - - Aminotran_1_2,GntR k141_209_29 1120985.AUMI01000011_gene144 4.42e-75 243.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4H1WE@909932|Negativicutes 909932|Negativicutes E threonine ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP k141_209_30 1121943.KB899990_gene3816 3.44e-42 155.0 COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,1RR4Y@1236|Gammaproteobacteria,1XPPU@135619|Oceanospirillales 135619|Oceanospirillales E Ornithine cyclodeaminase/mu-crystallin family - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k141_209_31 1235793.C809_03163 2.16e-30 117.0 COG0572@1|root,COG0572@2|Bacteria,1V1DZ@1239|Firmicutes,24FY8@186801|Clostridia,27P4E@186928|unclassified Lachnospiraceae 186801|Clostridia F Psort location Cytoplasmic, score - - - - - - - - - - - - PRK k141_209_32 1415774.U728_171 1.81e-87 277.0 2DH55@1|root,2ZYEV@2|Bacteria,1V5RJ@1239|Firmicutes,24K2G@186801|Clostridia,36K0U@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_209_33 293826.Amet_3695 2.04e-35 128.0 COG0716@1|root,COG0716@2|Bacteria,1VBEZ@1239|Firmicutes,24JJ6@186801|Clostridia,36K16@31979|Clostridiaceae 186801|Clostridia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4,Flavodoxin_5 k141_209_34 315730.BcerKBAB4_3016 3.29e-26 111.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - - - - - - - - - - MerR_1,TipAS k141_209_35 869213.JCM21142_41716 5.77e-11 72.8 COG0534@1|root,COG0534@2|Bacteria,4NDUF@976|Bacteroidetes,47PPJ@768503|Cytophagia 976|Bacteroidetes V MatE - - - - - - - - - - - - MatE k141_209_37 324057.Pjdr2_0827 4.58e-75 239.0 COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4H9NR@91061|Bacilli,26R39@186822|Paenibacillaceae 91061|Bacilli S ABC transporter, ATP-binding protein drrA1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k141_209_38 1449050.JNLE01000003_gene82 3.35e-13 75.5 COG4587@1|root,COG4587@2|Bacteria,1VDUN@1239|Firmicutes 1239|Firmicutes S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 k141_209_39 1405.DJ92_774 1.24e-50 172.0 COG3694@1|root,COG3694@2|Bacteria,1V0CD@1239|Firmicutes,4IRS3@91061|Bacilli 91061|Bacilli S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 k141_209_40 720554.Clocl_2972 5.35e-76 228.0 COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,3WJAK@541000|Ruminococcaceae 186801|Clostridia T low molecular weight arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k141_209_41 1122919.KB905561_gene1509 4.23e-23 109.0 COG1418@1|root,COG1418@2|Bacteria,1V7IZ@1239|Firmicutes,4HIVB@91061|Bacilli,26VIQ@186822|Paenibacillaceae 91061|Bacilli F phosphohydrolase - - - ko:K06950 - - - - ko00000 - - - HD k141_209_42 439292.Bsel_0686 7.49e-32 118.0 COG4446@1|root,COG4446@2|Bacteria,1VDZG@1239|Firmicutes,4HN9R@91061|Bacilli,26Q5T@186821|Sporolactobacillaceae 91061|Bacilli S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k141_209_43 445973.CLOBAR_00289 2.4e-199 567.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,25QYW@186804|Peptostreptococcaceae 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k141_194_1 1321778.HMPREF1982_02761 3.54e-72 221.0 COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,26890@186813|unclassified Clostridiales 186801|Clostridia C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.12.1.3,1.17.1.11,1.6.5.3 ko:K00334,ko:K18330,ko:K22340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k141_194_2 1321778.HMPREF1982_02760 0.0 885.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,268CT@186813|unclassified Clostridiales 186801|Clostridia C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region hymB - 1.12.1.3,1.17.1.11,1.6.5.3 ko:K00335,ko:K18331,ko:K22339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k141_194_3 1511.CLOST_0907 0.0 900.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia 186801|Clostridia C hydrogenase large subunit - - 1.12.1.3,1.6.5.3 ko:K00336,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iHN637.CLJU_RS07205 Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3 k141_194_5 192952.MM_3194 3.12e-93 296.0 COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,2NAD4@224756|Methanomicrobia 224756|Methanomicrobia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE k141_194_6 272623.L0248 1.33e-12 68.9 COG1846@1|root,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity rmaA - - - - - - - - - - - MarR,MarR_2 k141_194_7 1286171.EAL2_c00790 5.53e-219 621.0 COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,25VMR@186806|Eubacteriaceae 186801|Clostridia E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k141_194_8 521460.Athe_2101 4.76e-204 576.0 COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42F1K@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01703,ko:K20452 ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04465 Aconitase k141_194_9 445971.ANASTE_01888 1.37e-62 197.0 COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,25W2J@186806|Eubacteriaceae 186801|Clostridia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01704,ko:K20453 ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R10170 RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k141_194_10 1121342.AUCO01000019_gene1209 6.18e-123 365.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k141_194_11 1286171.EAL2_808p06750 9.22e-207 585.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,25UUM@186806|Eubacteriaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE k141_194_12 1286171.EAL2_c16430 5.56e-317 891.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,25VCX@186806|Eubacteriaceae 186801|Clostridia L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k141_194_13 1128398.Curi_c17620 5.81e-179 513.0 COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,268K1@186813|unclassified Clostridiales 186801|Clostridia E Aminopeptidase I zinc metalloprotease (M18) apeB - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k141_194_14 1280692.AUJL01000017_gene1028 5.93e-57 190.0 COG1752@1|root,COG1752@2|Bacteria,1V1ST@1239|Firmicutes,24GJT@186801|Clostridia,36IU0@31979|Clostridiaceae 186801|Clostridia S Patatin-like phospholipase - - - - - - - - - - - - Patatin k141_194_15 1121324.CLIT_10c04010 6.13e-48 163.0 COG0622@1|root,COG0622@2|Bacteria,1VBP8@1239|Firmicutes,24PBU@186801|Clostridia 186801|Clostridia S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k141_194_16 1286171.EAL2_c07210 2.74e-105 318.0 arCOG05878@1|root,2ZC5B@2|Bacteria,1V210@1239|Firmicutes,24GVY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_243_92 1196322.A370_04886 0.000211 43.1 2DYN9@1|root,34AEQ@2|Bacteria,1VZ6G@1239|Firmicutes,24UZU@186801|Clostridia,36S8P@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF4280) - - - - - - - - - - - - DUF4280 k141_243_93 1284352.AOIG01000043_gene25 5.17e-45 168.0 COG3501@1|root,COG3501@2|Bacteria,1V3I5@1239|Firmicutes,4IH8T@91061|Bacilli,26SP3@186822|Paenibacillaceae 91061|Bacilli T Rhs element vgr protein - - - - - - - - - - - - Colicin-DNase,Phage_GPD k141_243_96 1215092.PA6_031_00600 9.27e-12 63.9 2DQZH@1|root,339IV@2|Bacteria,1NIT0@1224|Proteobacteria,1SI7G@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k141_243_97 1121324.CLIT_5c00170 7.91e-95 287.0 COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,25REG@186804|Peptostreptococcaceae 186801|Clostridia ET Bacterial periplasmic substrate-binding proteins artP - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k141_243_98 1128398.Curi_c06880 2.28e-207 583.0 COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,26889@186813|unclassified Clostridiales 186801|Clostridia E Arginosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k141_243_99 536232.CLM_3034 1.57e-197 561.0 COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,36E9J@31979|Clostridiaceae 186801|Clostridia E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k141_241_103 1476973.JMMB01000007_gene3226 7.79e-156 446.0 COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,249PW@186801|Clostridia,25QUF@186804|Peptostreptococcaceae 186801|Clostridia G Bacterial fructose-1,6-bisphosphatase, glpX-encoded glpX - 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k141_241_104 1286171.EAL2_c03700 2.63e-210 596.0 COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia,25V0W@186806|Eubacteriaceae 186801|Clostridia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k141_241_105 997346.HMPREF9374_2413 5.51e-28 102.0 COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,4HNQF@91061|Bacilli,27C9Y@186824|Thermoactinomycetaceae 91061|Bacilli J Ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k141_241_106 1540257.JQMW01000013_gene916 5.81e-95 281.0 COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,24CVH@186801|Clostridia,36DU8@31979|Clostridiaceae 186801|Clostridia F thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK k141_241_107 1121324.CLIT_13c01210 5.05e-129 377.0 COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,25R91@186804|Peptostreptococcaceae 186801|Clostridia S Protein of unknown function (DUF1385) prmC - - - - - - - - - - - DUF1385,MTS k141_241_108 596329.HMPREF0631_1196 2.3e-64 211.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,25TC8@186804|Peptostreptococcaceae 186801|Clostridia J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k141_241_109 1121324.CLIT_13c01230 1.69e-178 506.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,25QD5@186804|Peptostreptococcaceae 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k141_241_110 697303.Thewi_0156 1.49e-107 325.0 COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,42ENS@68295|Thermoanaerobacterales 186801|Clostridia H Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine sua - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k141_241_111 656519.Halsa_0392 1.66e-28 110.0 COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia 186801|Clostridia T Low molecular weight phosphotyrosine protein phosphatase ywlE - 3.1.3.48,3.9.1.2 ko:K01104,ko:K20201 - - - - ko00000,ko01000 - - - LMWPc k141_241_112 1511.CLOST_2129 2.64e-67 207.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,25RC3@186804|Peptostreptococcaceae 186801|Clostridia G isomerase B rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k141_241_113 1511.CLOST_2128 1.01e-116 337.0 COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,25QEK@186804|Peptostreptococcaceae 186801|Clostridia F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k141_241_114 565033.GACE_0121 1.07e-67 209.0 COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,2464C@183980|Archaeoglobi 183980|Archaeoglobi F PFAM CMP dCMP deaminase zinc-binding - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k141_241_115 1121324.CLIT_13c01290 1.87e-120 358.0 COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,25R2V@186804|Peptostreptococcaceae 186801|Clostridia M Glycosyl transferase family 4 tagO - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k141_241_116 1121324.CLIT_13c01300 3.08e-181 514.0 COG0381@1|root,COG0381@2|Bacteria,1TQZT@1239|Firmicutes,247N7@186801|Clostridia 186801|Clostridia M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k141_241_117 293826.Amet_0344 1.31e-13 66.6 2DR0U@1|root,339Q9@2|Bacteria,1VK88@1239|Firmicutes,25Q6W@186801|Clostridia,36P1R@31979|Clostridiaceae 186801|Clostridia S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 k141_241_118 293826.Amet_0345 4.81e-22 92.4 2E5CI@1|root,3304M@2|Bacteria,1VGE2@1239|Firmicutes,24RE0@186801|Clostridia,36MX6@31979|Clostridiaceae 186801|Clostridia S ATP synthase I chain atpI2 - - - - - - - - - - - ATP-synt_I k141_241_119 1121324.CLIT_13c01330 1.52e-79 244.0 COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,25R3A@186804|Peptostreptococcaceae 186801|Clostridia C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k141_241_120 293826.Amet_0347 4.33e-85 255.0 COG0636@1|root,COG0636@2|Bacteria,1V1B0@1239|Firmicutes,24G2R@186801|Clostridia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - - - - - - - - - - ATP-synt_C k141_241_121 293826.Amet_0348 3.31e-46 149.0 COG0636@1|root,COG0636@2|Bacteria,1V8SD@1239|Firmicutes,24QMQ@186801|Clostridia,36MIS@31979|Clostridiaceae 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k141_241_122 1408422.JHYF01000012_gene3251 7.7e-17 80.9 COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,36M51@31979|Clostridiaceae 186801|Clostridia C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01170 ATP-synt_B k141_241_123 1265310.CCBD010000044_gene632 0.000824 47.4 COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,232X8@1762|Mycobacteriaceae 201174|Actinobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,OSCP k141_241_124 1511.CLOST_2118 3.5e-285 788.0 COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,25QJR@186804|Peptostreptococcaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k141_241_125 1286171.EAL2_c03910 6.36e-114 336.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,25VH1@186806|Eubacteriaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k141_241_126 1286171.EAL2_c03920 2.72e-288 793.0 COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,25UUG@186806|Eubacteriaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k141_241_127 1511.CLOST_2115 1.99e-38 133.0 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,25RTG@186804|Peptostreptococcaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01195 ATP-synt_DE,ATP-synt_DE_N k141_241_128 1121324.CLIT_13c01410 1.96e-37 137.0 2ECTX@1|root,336RF@2|Bacteria,1VGMY@1239|Firmicutes,24SIP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_241_129 1476973.JMMB01000007_gene3205 1.64e-40 138.0 COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,25RK6@186804|Peptostreptococcaceae 186801|Clostridia I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS01470 ACPS k141_241_130 1511.CLOST_2112 2.04e-139 409.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,25R0S@186804|Peptostreptococcaceae 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k141_241_131 1408422.JHYF01000003_gene842 1.03e-07 52.0 COG0864@1|root,COG0864@2|Bacteria,1VA28@1239|Firmicutes,24QKP@186801|Clostridia 186801|Clostridia K Transcriptional regulator, CopG family - - - ko:K07723 - - - - ko00000,ko02048,ko03000 - - - RHH_1 k141_241_132 386415.NT01CX_1266 8.19e-57 179.0 COG2337@1|root,COG2337@2|Bacteria,1V6DK@1239|Firmicutes,24JE1@186801|Clostridia,36IPB@31979|Clostridiaceae 186801|Clostridia L Toxic component of a toxin-antitoxin (TA) module ndoA - - ko:K07171 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin k141_241_133 457570.Nther_2387 1.08e-19 88.6 2E366@1|root,32Y5Z@2|Bacteria,1VFY1@1239|Firmicutes,24RE8@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_241_134 1121324.CLIT_13c01490 4.25e-160 484.0 2DBE5@1|root,2Z8QQ@2|Bacteria,1TPFD@1239|Firmicutes,24E93@186801|Clostridia,25QN4@186804|Peptostreptococcaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - - k141_241_135 1121324.CLIT_13c01500 4.5e-126 374.0 COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,25T1B@186804|Peptostreptococcaceae 186801|Clostridia S Polysaccharide pyruvyl transferase csaB - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans k141_241_136 1286171.EAL2_c04040 2.03e-91 276.0 COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,25XW7@186806|Eubacteriaceae 186801|Clostridia M Glycosyl transferase WecB/TagA/CpsF family tagA - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB,PS_pyruv_trans k141_241_137 293826.Amet_4138 3.18e-109 325.0 COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,36DT5@31979|Clostridiaceae 186801|Clostridia S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - DUF2179,YitT_membrane k141_241_138 1391646.AVSU01000012_gene1807 1.45e-143 412.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,25QJW@186804|Peptostreptococcaceae 186801|Clostridia G Transketolase - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k141_241_139 1408823.AXUS01000010_gene1879 3.38e-154 441.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,25QQ5@186804|Peptostreptococcaceae 186801|Clostridia G Transketolase - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k141_241_140 1347392.CCEZ01000010_gene2408 6.06e-228 649.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k141_241_141 796945.HMPREF1145_0343 3.26e-38 136.0 COG3331@1|root,COG3331@2|Bacteria,1V3S4@1239|Firmicutes,24G7S@186801|Clostridia,2PS13@265975|Oribacterium 186801|Clostridia L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation recU - - ko:K03700 - - - - ko00000,ko03400 - - - RecU k141_241_142 1121324.CLIT_14c00090 1.23e-148 426.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1TRJU@1239|Firmicutes,24AQW@186801|Clostridia 186801|Clostridia T response regulator receiver cheV - 2.7.13.3 ko:K03407,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,Response_reg k141_241_143 203119.Cthe_2356 5.19e-117 346.0 COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3WGEP@541000|Ruminococcaceae 186801|Clostridia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12020 NadA k141_241_144 926561.KB900622_gene511 4.85e-160 473.0 COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3WAHG@53433|Halanaerobiales 186801|Clostridia H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k141_241_145 203119.Cthe_2354 6.7e-89 272.0 COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,3WGJ1@541000|Ruminococcaceae 186801|Clostridia H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12010 QRPTase_C,QRPTase_N k141_241_146 1033810.HLPCO_002179 2.06e-181 521.0 COG0733@1|root,COG0733@2|Bacteria,2NNP4@2323|unclassified Bacteria 2|Bacteria S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k141_241_147 1408422.JHYF01000003_gene920 1.87e-32 122.0 2C9A0@1|root,32RNW@2|Bacteria,1VCW8@1239|Firmicutes,24HH9@186801|Clostridia,36IW5@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - NTP_transf_5,Rep_3 k141_241_148 37659.JNLN01000001_gene1339 3.94e-39 156.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - ABC_sub_bind,CHASE,EAL,GGDEF,PAS_3 k141_241_149 588581.Cpap_2172 1.03e-64 219.0 COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,24AQ9@186801|Clostridia,3WIXE@541000|Ruminococcaceae 186801|Clostridia S N-methylation of lysine residues in flagellin K00599 fliB - - ko:K18475 - - - - ko00000,ko01000,ko02035 - - - CxxCxxCC k141_241_150 1033737.CAEV01000025_gene379 1.5e-51 183.0 COG2508@1|root,COG2508@2|Bacteria,1V4GV@1239|Firmicutes,24HFE@186801|Clostridia,36VUQ@31979|Clostridiaceae 186801|Clostridia QT Purine catabolism regulatory protein-like family - - - - - - - - - - - - HTH_30,PucR k141_242_2 755731.Clo1100_2287 1.23e-113 331.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,36DZG@31979|Clostridiaceae 186801|Clostridia T response regulator, receiver phoP_1 - - - - - - - - - - - Response_reg,Trans_reg_C k141_242_3 293826.Amet_1274 2.68e-124 389.0 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,36DPS@31979|Clostridiaceae 186801|Clostridia T domain protein rpfG3 - - ko:K07814 - - - - ko00000,ko02022 - - - GAF_2,GGDEF,HD,HD_5,PAS_3,Response_reg k141_242_4 871963.Desdi_0151 2.36e-59 223.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,260AA@186807|Peptococcaceae 186801|Clostridia NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1,dCache_3 k141_242_5 926561.KB900617_gene1579 1.5e-187 540.0 COG1388@1|root,COG1785@1|root,COG1388@2|Bacteria,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,3WAZT@53433|Halanaerobiales 186801|Clostridia P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k141_242_6 1304284.L21TH_1802 9.78e-125 372.0 COG5438@1|root,COG5438@2|Bacteria,1TPEV@1239|Firmicutes,249SW@186801|Clostridia,36GKC@31979|Clostridiaceae 186801|Clostridia S YibE F family protein - - - - - - - - - - - - YibE_F k141_242_7 1121342.AUCO01000005_gene226 2.29e-43 154.0 COG1192@1|root,COG1192@2|Bacteria,1UI78@1239|Firmicutes,25ECF@186801|Clostridia,36I2D@31979|Clostridiaceae 186801|Clostridia D Involved in chromosome partitioning yqeC - - - - - - - - - - - - k141_242_8 86416.Clopa_0430 4.25e-113 340.0 COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,36E0K@31979|Clostridiaceae 186801|Clostridia S Selenium-dependent molybdenum hydroxylase system protein, YqeB family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3 k141_242_9 796940.HMPREF9628_01734 1.96e-79 248.0 COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,25RYR@186804|Peptostreptococcaceae 186801|Clostridia O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k141_242_10 796940.HMPREF9628_01735 2.56e-222 635.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,25STW@186804|Peptostreptococcaceae 186801|Clostridia KT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HTH_8,PAS_8,Sigma54_activat k141_242_11 1294142.CINTURNW_3659 2.47e-168 487.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36FIQ@31979|Clostridiaceae 186801|Clostridia F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine ssnA - 3.5.4.40 ko:K20810 ko00130,ko01110,map00130,map01110 - R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k141_242_12 796940.HMPREF9628_01736 2.68e-205 577.0 COG1171@1|root,COG1171@2|Bacteria,1TR70@1239|Firmicutes,2485T@186801|Clostridia,25SHS@186804|Peptostreptococcaceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme dpaL - 4.3.1.15 ko:K01751 - - - - ko00000,ko01000 - - - PALP k141_242_13 318464.IO99_12205 1.99e-251 694.0 COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,36G77@31979|Clostridiaceae 186801|Clostridia E peptidase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k141_242_14 1347392.CCEZ01000043_gene105 4.39e-204 568.0 COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,36F9U@31979|Clostridiaceae 186801|Clostridia E Belongs to the ATCase OTCase family - - - - - - - - - - - - OTCace,OTCace_N k141_242_15 1196322.A370_03992 9.81e-18 85.5 2FG4I@1|root,34811@2|Bacteria,1W01I@1239|Firmicutes,24NTK@186801|Clostridia,36SB8@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_242_16 536232.CLM_3283 1.94e-215 608.0 COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia,36DYC@31979|Clostridiaceae 186801|Clostridia F permease - - - ko:K03458 - - - - ko00000 2.A.40 - - Xan_ur_permease k141_242_17 1151292.QEW_3802 5.74e-175 498.0 COG0167@1|root,COG2768@1|root,COG0167@2|Bacteria,COG2768@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia 186801|Clostridia C Dihydroorotate dehydrogenase - - - - - - - - - - - - DHO_dh,Fer4 k141_242_18 748727.CLJU_c23790 2.19e-156 458.0 COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae 186801|Clostridia F PFAM amidohydrolase hydA - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k141_242_19 1230342.CTM_24995 0.0 1152.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k141_242_20 1128398.Curi_c25490 4.87e-30 115.0 COG1618@1|root,COG1618@2|Bacteria,1VGU5@1239|Firmicutes,24QRA@186801|Clostridia,269XU@186813|unclassified Clostridiales 186801|Clostridia F NTPase - - 3.6.1.15 ko:K06928 ko00230,ko00730,ko01100,map00230,map00730,map01100 - R00086,R00615 RC00002 ko00000,ko00001,ko01000 - - - MobB,NTPase_1 k141_242_21 189426.PODO_03935 5.97e-61 196.0 COG0745@1|root,COG0745@2|Bacteria,1V0F0@1239|Firmicutes,4HGH5@91061|Bacilli,26U77@186822|Paenibacillaceae 91061|Bacilli T regulator - - - - - - - - - - - - Response_reg,Trans_reg_C k141_242_22 742766.HMPREF9455_02349 1.14e-06 60.1 COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,4P0IA@976|Bacteroidetes,2FWSR@200643|Bacteroidia,22WGG@171551|Porphyromonadaceae 976|Bacteroidetes T Y_Y_Y domain - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k141_242_23 574375.BAGA_29345 2.4e-254 731.0 28IBY@1|root,2Z8EC@2|Bacteria,1TSCW@1239|Firmicutes,4HFBK@91061|Bacilli,1ZMDJ@1386|Bacillus 91061|Bacilli S Related to GH101 , GHL1-GHL3 family protein - - - - - - - - - - - - Glyco_hydro_129 k141_242_24 1196322.A370_04229 1.4e-50 166.0 2ER8Z@1|root,33IUK@2|Bacteria,1VYKS@1239|Firmicutes,24T3C@186801|Clostridia,36RH9@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_242_26 484019.THA_1039 3.34e-80 242.0 COG2109@1|root,COG2109@2|Bacteria,2GCV0@200918|Thermotogae 200918|Thermotogae H PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k141_242_27 1237149.C900_03643 2.13e-85 265.0 COG0668@1|root,COG0668@2|Bacteria,4NFHD@976|Bacteroidetes,47PJS@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k141_242_29 293826.Amet_3384 1.6e-60 190.0 COG0229@1|root,COG0229@2|Bacteria,1UPN0@1239|Firmicutes,25HJF@186801|Clostridia,36IR9@31979|Clostridiaceae 186801|Clostridia O methionine sulfoxide reductase msrB - 1.8.4.11,1.8.4.12 ko:K07304,ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - SelR k141_242_30 431943.CKL_3801 4.7e-101 300.0 COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,36DJK@31979|Clostridiaceae 186801|Clostridia K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k141_242_31 1511.CLOST_0711 9.17e-48 161.0 COG1633@1|root,COG1633@2|Bacteria,1VAXV@1239|Firmicutes,24KX7@186801|Clostridia 186801|Clostridia S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - DUF2202 k141_242_32 1121289.JHVL01000005_gene990 6.09e-187 535.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE k141_242_33 1293054.HSACCH_02152 7.09e-109 346.0 COG1307@1|root,COG1461@1|root,COG1307@2|Bacteria,COG1461@2|Bacteria,1TR6J@1239|Firmicutes,24A8H@186801|Clostridia,3WC9D@53433|Halanaerobiales 186801|Clostridia S Dak2 - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV k141_242_34 1511.CLOST_0666 1.26e-93 283.0 COG3752@1|root,COG3752@2|Bacteria,1V0FI@1239|Firmicutes,24GQX@186801|Clostridia 186801|Clostridia S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 k141_242_35 1499689.CCNN01000009_gene2762 2.18e-109 327.0 COG0803@1|root,COG0803@2|Bacteria,1TRKU@1239|Firmicutes,247UW@186801|Clostridia,36VMT@31979|Clostridiaceae 186801|Clostridia P Belongs to the bacterial solute-binding protein 9 family troA - - ko:K11707 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ZnuA k141_242_36 1347392.CCEZ01000021_gene843 1.33e-132 380.0 COG1121@1|root,COG1121@2|Bacteria,1TQJ3@1239|Firmicutes,25B2N@186801|Clostridia,36DZK@31979|Clostridiaceae 186801|Clostridia P ATPases associated with a variety of cellular activities mntA - 3.6.3.35 ko:K09817,ko:K09820,ko:K11710,ko:K19973 ko02010,map02010 M00242,M00243,M00319,M00792 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.15,3.A.1.15.3,3.A.1.15.5 - - ABC_tran k141_242_37 1347392.CCEZ01000021_gene842 5.62e-123 367.0 COG1108@1|root,COG1108@2|Bacteria,1TPZB@1239|Firmicutes,248FP@186801|Clostridia,36FPM@31979|Clostridiaceae 186801|Clostridia P ABC 3 transport family - - - ko:K09816,ko:K11708 ko02010,map02010 M00242,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k141_140_1 931276.Cspa_c09510 3.23e-103 317.0 COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia,36FIY@31979|Clostridiaceae 186801|Clostridia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 k141_65_1 1168034.FH5T_02805 1.1e-36 135.0 COG0697@1|root,COG0697@2|Bacteria,4NH9M@976|Bacteroidetes,2FPTW@200643|Bacteroidia 976|Bacteroidetes EG membrane - - - - - - - - - - - - EamA k141_200_2 1280685.AUKC01000012_gene1517 6.59e-56 181.0 COG2452@1|root,COG2452@2|Bacteria,1UZ1U@1239|Firmicutes,24F52@186801|Clostridia,4BYPI@830|Butyrivibrio 186801|Clostridia L Resolvase, N terminal domain - - - - - - - - - - - - MerR,MerR_1,Resolvase k141_98_1 1380384.JADN01000006_gene2538 2.93e-44 164.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,1HXF4@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k141_17_1 1007103.AFHW01000075_gene5666 3.1e-10 72.0 COG3501@1|root,COG3501@2|Bacteria,1TSS0@1239|Firmicutes,4HEI1@91061|Bacilli,276BN@186822|Paenibacillaceae 91061|Bacilli S Rhs element vgr protein - - - - - - - - - - - - Phage_GPD k141_201_1 866771.HMPREF9296_0050 1.67e-10 65.5 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family - - 2.7.13.3,3.4.21.102 ko:K03797,ko:K07680 ko02020,ko02024,map02020,map02024 M00476 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko02022 - - - Peptidase_S41,Tricorn_C1 k141_234_45 1408823.AXUS01000023_gene1725 8.64e-56 179.0 COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia,25RHX@186804|Peptostreptococcaceae 186801|Clostridia S Phosphoesterase yfcE1 - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k141_234_46 1286171.EAL2_c16310 9.13e-202 573.0 COG0127@1|root,COG0689@1|root,COG0127@2|Bacteria,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,25V9T@186806|Eubacteriaceae 186801|Clostridia J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C k141_234_47 546270.GEMHA0001_1082 1.26e-26 123.0 COG0860@1|root,COG5263@1|root,COG0860@2|Bacteria,COG5263@2|Bacteria,1VATU@1239|Firmicutes,4HN3V@91061|Bacilli,3WG55@539002|Bacillales incertae sedis 91061|Bacilli M Ami_3 amiD2 - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,CW_binding_1,LysM k141_234_48 1286171.EAL2_c07180 2.53e-99 303.0 COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,25UTJ@186806|Eubacteriaceae 186801|Clostridia O Psort location Cytoplasmic, score hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k141_234_49 1511.CLOST_0585 2.55e-244 688.0 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,25QPY@186804|Peptostreptococcaceae 186801|Clostridia E Psort location Periplasmic, score oppA - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k141_234_50 1121324.CLIT_10c04100 7.76e-189 530.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,25QJ4@186804|Peptostreptococcaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score appF - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k141_234_51 1123009.AUID01000005_gene1619 8.34e-195 546.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,2689V@186813|unclassified Clostridiales 186801|Clostridia EP Oligopeptide/dipeptide transporter, C-terminal region oppD - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k141_234_52 1121324.CLIT_10c04120 1.62e-163 464.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,25SV4@186804|Peptostreptococcaceae 186801|Clostridia EP N-terminal TM domain of oligopeptide transport permease C oppC - - ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k141_234_53 1286171.EAL2_c07080 2.93e-152 435.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,25WGI@186806|Eubacteriaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 oppB - - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k141_234_54 547045.NEISICOT_00066 1.77e-23 98.6 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,2VJPQ@28216|Betaproteobacteria,2KR5U@206351|Neisseriales 206351|Neisseriales Q isochorismatase family - - - - - - - - - - - - DUF2322,Isochorismatase k141_234_55 1168067.JAGP01000001_gene828 5.31e-48 181.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1RZ37@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k141_234_56 1286171.EAL2_c07070 3.8e-231 649.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,25VHC@186806|Eubacteriaceae 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k141_234_57 1286171.EAL2_c07060 7.92e-222 627.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,25V2X@186806|Eubacteriaceae 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k141_234_58 1304284.L21TH_1654 7.35e-28 103.0 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,36MP3@31979|Clostridiaceae 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k141_234_59 293826.Amet_3064 2.4e-80 276.0 COG0827@1|root,COG0827@2|Bacteria,1UHWQ@1239|Firmicutes,25E5N@186801|Clostridia,36UQ7@31979|Clostridiaceae 186801|Clostridia LV TaqI-like C-terminal specificity domain - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I,HSDR_N,HTH_17,N6_Mtase,TaqI_C k141_234_61 1078085.HMPREF1210_01640 5.17e-07 60.8 COG1657@1|root,COG2247@1|root,COG1657@2|Bacteria,COG2247@2|Bacteria,1UZVS@1239|Firmicutes,4HDE7@91061|Bacilli,26GAC@186818|Planococcaceae 91061|Bacilli I Belongs to the peptidase S8 family - - - - - - - - - - - - Big_2,DUF4430,Gram_pos_anchor,Prenyltrans,SLH,SQHop_cyclase_C k141_234_62 748727.CLJU_c08990 3.56e-06 57.0 COG4886@1|root,COG5279@1|root,COG4886@2|Bacteria,COG5279@2|Bacteria,1V8TE@1239|Firmicutes,24CI3@186801|Clostridia,36GZB@31979|Clostridiaceae 186801|Clostridia D transglutaminase - - - - - - - - - - - - Big_5,Cu_amine_oxidN1,Transglut_core k141_234_63 1121289.JHVL01000017_gene777 6.04e-54 188.0 COG1657@1|root,COG2373@1|root,COG1657@2|Bacteria,COG2373@2|Bacteria,1U1T6@1239|Firmicutes,24EBP@186801|Clostridia 186801|Clostridia I S-layer homology domain - - - - - - - - - - - - SLH k141_234_64 1121289.JHVL01000017_gene781 1.54e-74 231.0 COG4720@1|root,COG4720@2|Bacteria,1V2DR@1239|Firmicutes,249XR@186801|Clostridia,36F8J@31979|Clostridiaceae 186801|Clostridia S ECF-type riboflavin transporter, S component - - - ko:K16927 - M00582 - - ko00000,ko00002,ko02000 3.A.1.32 - - ECF-ribofla_trS,ECF_trnsprt k141_234_65 1499689.CCNN01000007_gene1133 6.38e-129 394.0 COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,36UJA@31979|Clostridiaceae 186801|Clostridia S ATPases associated with a variety of cellular activities - - - ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k141_234_67 1157490.EL26_03015 2.34e-20 98.6 28RTZ@1|root,2ZE6B@2|Bacteria,1V1HK@1239|Firmicutes,4IC1K@91061|Bacilli,27AB7@186823|Alicyclobacillaceae 91061|Bacilli S Domain of unknown function (DUF4430) - - - - - - - - - - - - DUF4430 k141_234_68 1391646.AVSU01000099_gene362 3.42e-60 202.0 COG1082@1|root,COG1082@2|Bacteria,1U2VB@1239|Firmicutes,24EE7@186801|Clostridia 186801|Clostridia G PFAM Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 k141_234_70 1033810.HLPCO_001959 1.1e-178 512.0 COG1055@1|root,COG1055@2|Bacteria,2NPE3@2323|unclassified Bacteria 2|Bacteria P Arsenical pump membrane protein arsA - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - CitMHS k141_234_71 1511.CLOST_1011 3.54e-52 170.0 2C1XY@1|root,32SVI@2|Bacteria,1VCSR@1239|Firmicutes,25CZT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_234_72 1511.CLOST_1011 3.69e-53 173.0 2C1XY@1|root,32SVI@2|Bacteria,1VCSR@1239|Firmicutes,25CZT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - k141_21_1 293826.Amet_2616 4.08e-229 651.0 COG1961@1|root,COG1961@2|Bacteria,1TS5B@1239|Firmicutes,24BET@186801|Clostridia,36ET1@31979|Clostridiaceae 186801|Clostridia L Resolvase, N terminal domain - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k141_121_1 394503.Ccel_3460 3.97e-177 522.0 COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,36DG9@31979|Clostridiaceae 186801|Clostridia E oligoendopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k141_121_2 1121324.CLIT_23c02190 5.76e-226 632.0 COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,25QCD@186804|Peptostreptococcaceae 186801|Clostridia E 2-hydroxyglutaryl-CoA dehydratase - - - - - - - - - - - - HGD-D k141_121_3 1540257.JQMW01000011_gene2191 7.06e-14 67.8 2DR4V@1|root,33A63@2|Bacteria,1VKGM@1239|Firmicutes,24SDY@186801|Clostridia,36MWE@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF3343) - - - - - - - - - - - - DUF3343 k141_121_4 273068.TTE1113 1.59e-65 219.0 COG1775@1|root,COG1924@1|root,COG1775@2|Bacteria,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,42F39@68295|Thermoanaerobacterales 186801|Clostridia I PFAM ATPase, BadF BadG BcrA BcrD type hgdC_1 - - - - - - - - - - - BcrAD_BadFG,HGD-D k141_121_5 864565.HMPREF0379_0916 5.9e-121 365.0 COG3434@1|root,COG3434@2|Bacteria,1TPWC@1239|Firmicutes,248M1@186801|Clostridia,25TG5@186804|Peptostreptococcaceae 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,HDOD k141_121_6 635013.TherJR_2416 1.05e-103 315.0 COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia,2621Y@186807|Peptococcaceae 186801|Clostridia E PFAM Beta-eliminating lyase ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k141_121_7 1304284.L21TH_1589 3.37e-197 561.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,36F13@31979|Clostridiaceae 186801|Clostridia E amino acid carrier protein agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k141_121_8 1121324.CLIT_5c00530 1.74e-93 281.0 COG2859@1|root,COG2859@2|Bacteria,1V1Q4@1239|Firmicutes,24GEE@186801|Clostridia 186801|Clostridia L Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k141_121_11 1123009.AUID01000029_gene430 6.29e-188 529.0 COG3177@1|root,COG3177@2|Bacteria,1TQMC@1239|Firmicutes,248JU@186801|Clostridia,26A60@186813|unclassified Clostridiales 186801|Clostridia S Fic/DOC family - - - - - - - - - - - - Fic k141_121_12 1499689.CCNN01000014_gene3235 1.34e-64 214.0 2A2TX@1|root,30R7T@2|Bacteria,1VC6M@1239|Firmicutes,24EGB@186801|Clostridia,36H2H@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF3829) - - - - - - - - - - - - DUF3829 k141_121_15 335541.Swol_1096 1.46e-144 432.0 COG4124@1|root,COG4124@2|Bacteria,1U8S3@1239|Firmicutes,24C93@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 26 - - - - - - - - - - - - Glyco_hydro_26 k141_121_16 293826.Amet_3704 4.15e-108 335.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae 186801|Clostridia C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k141_121_17 865861.AZSU01000006_gene1368 2.96e-54 175.0 29CHX@1|root,2ZZGD@2|Bacteria,1V7PD@1239|Firmicutes,24HKB@186801|Clostridia,36IP9@31979|Clostridiaceae 186801|Clostridia S HutP hutP - - - - - - - - - - - HutP k141_121_18 1121289.JHVL01000028_gene509 2.41e-147 425.0 COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,36EPA@31979|Clostridiaceae 186801|Clostridia S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k141_121_19 521460.Athe_2641 4.9e-27 100.0 COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,42H6Q@68295|Thermoanaerobacterales 186801|Clostridia CO redox-active disulfide protein 2 - - - - - - - - - - - - Thioredoxin_3 k141_121_20 1487921.DP68_12495 9.12e-35 130.0 2AYHW@1|root,31QMC@2|Bacteria,1V6S7@1239|Firmicutes,24NBV@186801|Clostridia,36JKA@31979|Clostridiaceae 186801|Clostridia S TraX protein - - - - - - - - - - - - TraX k141_121_22 12336.Q332K6_CBCP 2.95e-72 219.0 4QH1U@10239|Viruses,4QW4R@35237|dsDNA viruses no RNA stage,4QPQW@28883|Caudovirales,4QJ32@10662|Myoviridae 10662|Myoviridae S Transposase IS200 like - - - - - - - - - - - - - k141_121_23 1410674.JNKU01000042_gene2164 1.02e-209 597.0 COG0675@1|root,COG0675@2|Bacteria,1TQKT@1239|Firmicutes,4HDNU@91061|Bacilli,3FA7E@33958|Lactobacillaceae 91061|Bacilli L Transposase, IS605 OrfB family - - - - - - - - - - - - OrfB_IS605 k141_121_25 865861.AZSU01000006_gene1369 2.96e-113 338.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,36EB5@31979|Clostridiaceae 186801|Clostridia S ABC transporter - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k141_121_26 1347392.CCEZ01000019_gene1060 1.89e-96 292.0 COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia,36EMV@31979|Clostridiaceae 186801|Clostridia S Belongs to the binding-protein-dependent transport system permease family - - - ko:K05832 - M00247 - - ko00000,ko00002,ko02000 - - - BPD_transp_2 k141_121_27 596323.HMPREF0554_0235 3.35e-80 249.0 COG1101@1|root,COG1101@2|Bacteria,378KE@32066|Fusobacteria 32066|Fusobacteria S ABC transporter - - - ko:K05833 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_tran k141_121_30 1469948.JPNB01000001_gene710 1.85e-25 99.8 COG3422@1|root,COG3422@2|Bacteria,1VDBT@1239|Firmicutes,24PRF@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF1508) - - - ko:K09946 - - - - ko00000 - - - DUF1508 k141_194_17 1121289.JHVL01000012_gene1709 1.5e-153 449.0 COG3681@1|root,COG3681@2|Bacteria,1TQF5@1239|Firmicutes,2488Q@186801|Clostridia,36EM7@31979|Clostridiaceae 186801|Clostridia S Belongs to the UPF0597 family - - - - - - - - - - - - SDH_alpha k141_194_18 1095747.HMPREF1049_1678 3.71e-88 275.0 COG0502@1|root,COG0502@2|Bacteria,379PA@32066|Fusobacteria 32066|Fusobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k141_194_19 500633.CLOHIR_01707 1.08e-19 84.3 2EBCU@1|root,335DI@2|Bacteria,1VENS@1239|Firmicutes,24T2K@186801|Clostridia,25TNR@186804|Peptostreptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_194_20 1304284.L21TH_0336 7.33e-144 415.0 COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,36DHV@31979|Clostridiaceae 186801|Clostridia S radical SAM protein - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k141_194_21 1131462.DCF50_p1615 1.09e-34 121.0 COG0640@1|root,COG0640@2|Bacteria,1VF14@1239|Firmicutes,24MW7@186801|Clostridia,262SE@186807|Peptococcaceae 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor pagR - - - - - - - - - - - HTH_20,HTH_5 k141_194_22 1121324.CLIT_2c01920 0.0 1180.0 COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,25QTC@186804|Peptostreptococcaceae 186801|Clostridia P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain cdr - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k141_194_23 1121324.CLIT_10c03990 4.05e-115 341.0 COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,25TGR@186804|Peptostreptococcaceae 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA k141_194_24 1391646.AVSU01000075_gene2795 5.73e-136 402.0 COG0477@1|root,COG2814@2|Bacteria,1TS1D@1239|Firmicutes,24CUT@186801|Clostridia,25TU4@186804|Peptostreptococcaceae 186801|Clostridia EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,Sugar_tr k141_194_25 500633.CLOHIR_01709 6.03e-58 191.0 COG0727@1|root,COG0727@2|Bacteria,1VIET@1239|Firmicutes,24UUA@186801|Clostridia,25S95@186804|Peptostreptococcaceae 186801|Clostridia S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k141_194_26 332101.JIBU02000001_gene4330 6.71e-229 656.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02688 - - - - ko00000,ko03000 - - - HTH_8,PAS,PAS_4,PAS_8,PAS_9,PrpR_N,Sigma54_activat k141_194_27 1123288.SOV_2c04360 0.0 894.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,4H1XI@909932|Negativicutes 909932|Negativicutes C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,Fer4_21,POR_N,TPP_enzyme_C k141_194_28 1123288.SOV_2c04350 3.17e-99 291.0 COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,4H4Q5@909932|Negativicutes 909932|Negativicutes C Pyruvate ferredoxin/flavodoxin oxidoreductase - - - - - - - - - - - - POR k141_194_29 1286171.EAL2_808p06620 1.92e-94 281.0 28JAU@1|root,2ZYJS@2|Bacteria,1UPNS@1239|Firmicutes,25HK7@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_194_30 536227.CcarbDRAFT_2467 4.62e-183 517.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36GMK@31979|Clostridiaceae 186801|Clostridia C PFAM acetate and butyrate kinase buk - 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase k141_194_31 1540257.JQMW01000009_gene3118 7.96e-145 427.0 COG1114@1|root,COG1114@2|Bacteria,1TQIS@1239|Firmicutes,248I0@186801|Clostridia,36DC1@31979|Clostridiaceae 186801|Clostridia E Component of the transport system for branched-chain amino acids - - - ko:K03311 - - - - ko00000 2.A.26 - - Branch_AA_trans k141_194_32 1540257.JQMW01000009_gene3118 9.48e-146 429.0 COG1114@1|root,COG1114@2|Bacteria,1TQIS@1239|Firmicutes,248I0@186801|Clostridia,36DC1@31979|Clostridiaceae 186801|Clostridia E Component of the transport system for branched-chain amino acids - - - ko:K03311 - - - - ko00000 2.A.26 - - Branch_AA_trans k141_194_33 997296.PB1_08512 3.14e-170 534.0 COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria,1VKCH@1239|Firmicutes,4IS68@91061|Bacilli,1ZS2A@1386|Bacillus 91061|Bacilli M Fn3 associated XK27_02140 - - ko:K07004 - - - - ko00000 - - - CHB_HEX_C_1,Exo_endo_phos,Fn3_assoc,Gram_pos_anchor,LTD,SLH k141_194_34 1286171.EAL2_c07320 2.91e-168 476.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,25UWN@186806|Eubacteriaceae 186801|Clostridia G Fructose-1,6-bisphosphate aldolase, class II fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k141_213_2 592027.CLG_B0203 0.000501 47.4 COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,36FR1@31979|Clostridiaceae 186801|Clostridia M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,Big_4,Big_5,CW_binding_2,SH3_3 k141_195_1 1415774.U728_324 1.1e-75 263.0 COG0642@1|root,COG2205@2|Bacteria,1TP73@1239|Firmicutes,248Y6@186801|Clostridia,36ERK@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k141_195_2 999411.HMPREF1092_03035 1.12e-81 253.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,36EEP@31979|Clostridiaceae 186801|Clostridia HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k141_195_3 332101.JIBU02000018_gene2328 6.26e-104 315.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k141_195_4 1292035.H476_0768 2.58e-80 254.0 COG0614@1|root,COG0614@2|Bacteria,1TSAF@1239|Firmicutes,24ITQ@186801|Clostridia,25SE3@186804|Peptostreptococcaceae 186801|Clostridia P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k141_195_5 1151292.QEW_4267 2.58e-64 229.0 COG0584@1|root,COG4781@1|root,COG0584@2|Bacteria,COG4781@2|Bacteria,1UGF1@1239|Firmicutes,25E4R@186801|Clostridia,25TP7@186804|Peptostreptococcaceae 186801|Clostridia C Membrane domain of glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,GPDPase_memb k141_195_6 469381.Dpep_0470 1.01e-102 318.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k141_195_7 1256908.HMPREF0373_03059 1.6e-43 144.0 COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24J8R@186801|Clostridia,25WII@186806|Eubacteriaceae 186801|Clostridia S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k141_195_8 1385514.N782_05670 2.45e-116 337.0 COG3153@1|root,COG3153@2|Bacteria,1V3PW@1239|Firmicutes,4HGZK@91061|Bacilli,2YBRN@289201|Pontibacillus 91061|Bacilli S Acetyltransferase (GNAT) domain - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_9 k141_195_9 572544.Ilyop_0956 4.42e-116 336.0 COG0655@1|root,COG0655@2|Bacteria,37A1W@32066|Fusobacteria 32066|Fusobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k141_195_10 1487921.DP68_13015 2.98e-88 262.0 COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,36I36@31979|Clostridiaceae 186801|Clostridia C nitroreductase - - - - - - - - - - - - Nitroreductase k141_195_11 425104.Ssed_2097 4.75e-35 135.0 COG2207@1|root,COG2207@2|Bacteria,1RB3B@1224|Proteobacteria,1S2BJ@1236|Gammaproteobacteria,2QB7A@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18 k141_186_17 555088.DealDRAFT_2490 2.84e-14 72.0 COG1863@1|root,COG1863@2|Bacteria,1VEJ0@1239|Firmicutes,24REY@186801|Clostridia 186801|Clostridia P PFAM cation antiporter - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k141_186_19 1121324.CLIT_23c00150 2.43e-276 779.0 COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,25UPX@186804|Peptostreptococcaceae 186801|Clostridia K Bacterial regulatory protein, Fis family - - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,PAS,PAS_9,Sigma54_activat k141_186_20 1395571.TMS3_0115430 4.79e-07 59.3 COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,1RPY9@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k141_186_21 536233.CLO_0219 7e-14 66.6 COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,24RMA@186801|Clostridia,36P1S@31979|Clostridiaceae 186801|Clostridia P Heavy metal transport detoxification protein copZ - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA k141_186_22 521460.Athe_2280 1.27e-280 800.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales 186801|Clostridia P Heavy metal transport detoxification protein copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k141_121_32 1151292.QEW_3400 2.19e-81 270.0 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,25R0J@186804|Peptostreptococcaceae 186801|Clostridia S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k141_121_33 1211817.CCAT010000043_gene3484 2.06e-234 659.0 COG1757@1|root,COG1757@2|Bacteria,1TQPI@1239|Firmicutes,25MHZ@186801|Clostridia,36F0F@31979|Clostridiaceae 186801|Clostridia C Na+/H+ antiporter family - - - - - - - - - - - - Na_H_antiporter k141_121_36 935837.JAEK01000007_gene3282 6.38e-177 513.0 COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,4H9V4@91061|Bacilli,1ZCKC@1386|Bacillus 91061|Bacilli P COG0659 Sulfate permease and related transporters (MFS superfamily) ybaR - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k141_121_38 272563.CD630_27790 1.41e-155 448.0 COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,25T1R@186804|Peptostreptococcaceae 186801|Clostridia M Mannose-6-phosphate isomerase manC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k141_121_39 1408823.AXUS01000011_gene2023 4.62e-46 167.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,25SIR@186804|Peptostreptococcaceae 186801|Clostridia K helix_turn _helix lactose operon repressor rbsR - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k141_121_40 1121324.CLIT_12c00220 1.24e-63 204.0 2BDGA@1|root,3275F@2|Bacteria,1UT1B@1239|Firmicutes,250U0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_121_41 1121324.CLIT_12c00230 0.0 1229.0 COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,25R40@186804|Peptostreptococcaceae 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind,SecA_SW k141_121_42 29176.XP_003884624.1 4.86e-22 110.0 COG1404@1|root,KOG1153@2759|Eukaryota,3YFEN@5794|Apicomplexa,3YIEN@5796|Coccidia,3YSCI@5809|Sarcocystidae 5794|Apicomplexa O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 k141_121_43 324057.Pjdr2_5781 3.11e-09 70.1 COG3103@1|root,COG3103@2|Bacteria,1UJG3@1239|Firmicutes 1239|Firmicutes T S-layer homology domain - - - - - - - - - - - - SLH k141_121_44 1209989.TepiRe1_2680 1.39e-165 485.0 COG2755@1|root,COG2755@2|Bacteria,1TS9T@1239|Firmicutes,24961@186801|Clostridia 186801|Clostridia E S-layer homology domain - - - - - - - - - - - - SLH k141_121_45 1209989.TepiRe1_2681 1.9e-131 412.0 2DBEI@1|root,2Z8SE@2|Bacteria,1UYCK@1239|Firmicutes,247WI@186801|Clostridia,42J8P@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - SLH k141_235_4 1286171.EAL2_808p04630 2.81e-99 295.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,25UU1@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score srrA - - - - - - - - - - - Response_reg,Trans_reg_C k141_235_5 1286171.EAL2_808p04620 1.84e-99 318.0 COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,25ZKB@186806|Eubacteriaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA k141_235_10 1286171.EAL2_c08260 0.0 946.0 COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,25UUY@186806|Eubacteriaceae 186801|Clostridia T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 k141_235_11 485918.Cpin_6785 3.78e-36 134.0 2EJ04@1|root,325K7@2|Bacteria,4P37X@976|Bacteroidetes 976|Bacteroidetes S Suppressor of fused protein (SUFU) - - - - - - - - - - - - SUFU k141_235_12 1220589.CD32_08830 8.26e-62 196.0 COG1859@1|root,COG1859@2|Bacteria,1V49Y@1239|Firmicutes,4HHHZ@91061|Bacilli 91061|Bacilli J Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase kptA - - ko:K07559 - - - - ko00000,ko01000,ko03016 - - - PTS_2-RNA k141_235_15 608506.COB47_0918 7.61e-63 206.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia,42FKH@68295|Thermoanaerobacterales 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k141_235_16 1007096.BAGW01000023_gene203 2.06e-33 128.0 COG3187@1|root,COG3187@2|Bacteria,1UMA9@1239|Firmicutes,25GDD@186801|Clostridia 186801|Clostridia O Heat shock protein - - - - - - - - - - - - - k141_235_17 103690.17135348 1.2e-91 279.0 COG2746@1|root,COG2746@2|Bacteria,1GHME@1117|Cyanobacteria,1HK71@1161|Nostocales 1117|Cyanobacteria V Aminoglycoside 3-N-acetyltransferase - - 2.3.1.81 ko:K00662 - - - - ko00000,ko01000,ko01504 - - - Antibiotic_NAT k141_235_19 1408439.JHXW01000001_gene1808 1.34e-314 891.0 COG0247@1|root,COG0493@1|root,COG0247@2|Bacteria,COG0493@2|Bacteria,37A5A@32066|Fusobacteria 32066|Fusobacteria CE Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - CCG,Fer4_17,Fer4_20,Pyr_redox_2 k141_235_20 1319815.HMPREF0202_01366 7.75e-134 390.0 COG0697@1|root,COG0697@2|Bacteria,37AUN@32066|Fusobacteria 32066|Fusobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k141_235_21 1121342.AUCO01000036_gene1045 3.16e-110 345.0 COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae 186801|Clostridia KQ Sigma54 specific transcriptional regulator, Fis family stc2 - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,PAS,PAS_9,Sigma54_activat k141_39_2 1511.CLOST_1676 9.32e-66 210.0 COG3409@1|root,COG3409@2|Bacteria,1VGC4@1239|Firmicutes,24R4H@186801|Clostridia 186801|Clostridia M Flagellar rod assembly protein muramidase FlgJ - - - - - - - - - - - - CW_binding_1,PG_binding_1 k141_39_3 1216932.CM240_3157 2.78e-57 184.0 COG0262@1|root,COG0262@2|Bacteria,1VAUA@1239|Firmicutes,24G7Y@186801|Clostridia,36IEA@31979|Clostridiaceae 186801|Clostridia H Riboflavin biosynthesis protein RibD - - - - - - - - - - - - RibD_C k141_39_4 526222.Desal_1269 0.0 1055.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2WJPB@28221|Deltaproteobacteria,2MABY@213115|Desulfovibrionales 28221|Deltaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k141_39_5 1033737.CAEV01000002_gene2214 8.54e-75 229.0 COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,24IQJ@186801|Clostridia,36FVN@31979|Clostridiaceae 186801|Clostridia K GrpB protein - - - - - - - - - - - - Acetyltransf_1,GrpB,NUDIX k141_39_7 411470.RUMGNA_03685 1.11e-169 489.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,3XZ7R@572511|Blautia 186801|Clostridia F COG COG0402 Cytosine deaminase and related metal-dependent hydrolases guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k141_39_8 1304284.L21TH_0006 8.09e-37 142.0 COG0457@1|root,COG0457@2|Bacteria,1UJ4B@1239|Firmicutes,25EVP@186801|Clostridia,36JRU@31979|Clostridiaceae 186801|Clostridia S Copper amine oxidase N-terminal domain - - - - - - - - - - - - Cu_amine_oxidN1 k141_39_9 931276.Cspa_c21800 2.51e-51 166.0 2E89A@1|root,332N5@2|Bacteria,1VEKY@1239|Firmicutes,25HQB@186801|Clostridia,36VBW@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k141_39_11 1443125.Z962_06695 9.54e-175 494.0 COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia,36EBC@31979|Clostridiaceae 186801|Clostridia V PFAM peptidase U61, LD-carboxypeptidase A mccF - - - - - - - - - - - Peptidase_S66 k141_39_12 1262449.CP6013_2783 1.6e-66 222.0 COG1413@1|root,COG1413@2|Bacteria,1V0R4@1239|Firmicutes,24IWZ@186801|Clostridia 186801|Clostridia C lyase activity - - - - - - - - - - - - - k141_39_13 1051501.AYTL01000028_gene1709 1.75e-23 94.4 COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,4HH0A@91061|Bacilli,1ZHCV@1386|Bacillus 91061|Bacilli K Transcriptional regulator yybR - - - - - - - - - - - HxlR k141_39_14 641107.CDLVIII_4284 3.85e-89 266.0 COG1853@1|root,COG1853@2|Bacteria,1TSTQ@1239|Firmicutes,24FYK@186801|Clostridia,36EHC@31979|Clostridiaceae 186801|Clostridia S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k141_39_15 626369.HMPREF0446_00709 6e-39 141.0 COG1011@1|root,COG1011@2|Bacteria,1TWM7@1239|Firmicutes,4HEXU@91061|Bacilli,27HEI@186828|Carnobacteriaceae 91061|Bacilli S HAD-hyrolase-like yfnB - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k141_39_16 1158612.I580_02970 1.54e-54 180.0 COG2364@1|root,COG2364@2|Bacteria,1U63V@1239|Firmicutes,4HJ91@91061|Bacilli,4B184@81852|Enterococcaceae 91061|Bacilli S Membrane - - - - - - - - - - - - - k141_39_17 457396.CSBG_00183 1.18e-34 124.0 COG1051@1|root,COG1051@2|Bacteria,1UK8J@1239|Firmicutes,25FQJ@186801|Clostridia,36V0F@31979|Clostridiaceae 186801|Clostridia F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k141_39_18 198467.NP92_00935 1.27e-74 232.0 COG0300@1|root,COG0300@2|Bacteria,1U5VD@1239|Firmicutes,4HES8@91061|Bacilli,21VC8@150247|Anoxybacillus 91061|Bacilli S Enoyl-(Acyl carrier protein) reductase - - - ko:K07124 - - - - ko00000 - - - adh_short k141_39_20 931276.Cspa_c40570 5.01e-151 432.0 COG3586@1|root,COG3586@2|Bacteria,1U3JM@1239|Firmicutes,24BQ9@186801|Clostridia 186801|Clostridia L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - - - - - - - - - - NucS k141_39_21 546269.HMPREF0389_01439 2.12e-110 337.0 COG3593@1|root,COG3593@2|Bacteria,1VFE2@1239|Firmicutes,25G9C@186801|Clostridia 186801|Clostridia L AAA ATPase domain - - - - - - - - - - - - AAA_15 k141_39_22 546269.HMPREF0389_01440 1.89e-43 149.0 2DJAI@1|root,30597@2|Bacteria,1VP8U@1239|Firmicutes,24XDN@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k141_39_23 574376.BAMA_23000 1.1e-48 167.0 COG1451@1|root,COG1451@2|Bacteria,1V0CS@1239|Firmicutes,4HE0S@91061|Bacilli,1ZBQ8@1386|Bacillus 91061|Bacilli S WLM domain - - - ko:K07043 - - - - ko00000 - - - DUF45 k141_39_24 1291050.JAGE01000002_gene3828 7.27e-32 112.0 COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,24QV3@186801|Clostridia,3WJWY@541000|Ruminococcaceae 186801|Clostridia S Transcriptional Coactivator p15 (PC4) - - - - - - - - - - - - PC4 k141_39_28 1234679.BN424_2281 3.22e-110 338.0 COG0534@1|root,COG0534@2|Bacteria,1V3MS@1239|Firmicutes,4HI19@91061|Bacilli 91061|Bacilli V MatE - - - ko:K18908 - M00705 - - ko00000,ko00002,ko01504,ko02000 2.A.66.1.13 - - MatE k141_39_29 350688.Clos_1703 2.01e-56 182.0 COG1670@1|root,COG1670@2|Bacteria,1UI20@1239|Firmicutes,24HRV@186801|Clostridia,36JDG@31979|Clostridiaceae 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_4 k141_39_31 1410653.JHVC01000003_gene3820 1.79e-87 274.0 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,36E87@31979|Clostridiaceae 186801|Clostridia P transport protein CorA corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k141_39_32 1165096.ARWF01000001_gene915 7.91e-43 167.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE1,PAS,PAS_3,PAS_4,PAS_9 k141_39_34 1347392.CCEZ01000004_gene783 8.01e-32 117.0 COG1342@1|root,COG1342@2|Bacteria,1V7UV@1239|Firmicutes,24D5E@186801|Clostridia,36M1V@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF134 - - - - - - - - - - - - DUF134 k141_39_36 36875.HQ29_03930 3.47e-06 58.5 COG0793@1|root,COG0793@2|Bacteria,4PJ38@976|Bacteroidetes,2G1RE@200643|Bacteroidia,2313Z@171551|Porphyromonadaceae 976|Bacteroidetes M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k141_39_38 1121324.CLIT_10c05490 8.11e-241 669.0 COG1653@1|root,COG1653@2|Bacteria,1TT8P@1239|Firmicutes,24DVQ@186801|Clostridia,25U8K@186804|Peptostreptococcaceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 k141_39_39 272563.CD630_25490 1.39e-91 281.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24FFB@186801|Clostridia,25UI6@186804|Peptostreptococcaceae 186801|Clostridia U Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k141_39_40 1121324.CLIT_10c05510 5.02e-123 358.0 COG0395@1|root,COG0395@2|Bacteria,1TR01@1239|Firmicutes,249Z7@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k141_39_41 1292035.H476_2567 8.62e-71 246.0 COG3934@1|root,COG4552@1|root,COG3934@2|Bacteria,COG4552@2|Bacteria,1TRIX@1239|Firmicutes,25EXH@186801|Clostridia,25S7I@186804|Peptostreptococcaceae 186801|Clostridia G Domain of unknown function (DUF4091) - - - - - - - - - - - - DUF4091 k141_39_42 1151292.QEW_3091 1.6e-177 521.0 COG3934@1|root,COG3934@2|Bacteria,1TRIX@1239|Firmicutes,25EXH@186801|Clostridia,25S7I@186804|Peptostreptococcaceae 186801|Clostridia G Domain of unknown function (DUF4091) - - - - - - - - - - - - DUF4091 k141_39_43 754027.HMPREF9554_01513 2.43e-169 486.0 COG1301@1|root,COG1301@2|Bacteria,2J63V@203691|Spirochaetes 203691|Spirochaetes U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k141_39_46 1220589.CD32_17485 1.27e-27 110.0 COG2184@1|root,COG2184@2|Bacteria,1TPUZ@1239|Firmicutes,4HIQT@91061|Bacilli 91061|Bacilli D Fic/DOC family fic - - ko:K04095 - - - - ko00000,ko03036 - - - Fic k141_39_47 1301100.HG529403_gene6774 1.05e-126 365.0 COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,36E08@31979|Clostridiaceae 186801|Clostridia K transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg k141_39_48 767817.Desgi_4573 7.46e-23 90.5 COG2161@1|root,COG2161@2|Bacteria,1VFIZ@1239|Firmicutes,24PQN@186801|Clostridia 186801|Clostridia D Antitoxin component of a toxin-antitoxin (TA) module - - - ko:K19159 - - - - ko00000,ko02048 - - - PhdYeFM_antitox k141_39_49 1169161.KB897741_gene1902 7.03e-29 105.0 COG4115@1|root,COG4115@2|Bacteria,2IQAJ@201174|Actinobacteria 201174|Actinobacteria S addiction module toxin, Txe YoeB family - - - ko:K19158 - - - - ko00000,ko01000,ko02048 - - - YoeB_toxin k141_39_50 1286171.EAL2_c11720 4.37e-80 246.0 COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,25WNA@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF554) - - - ko:K07150 - - - - ko00000 - - - DUF554 k141_39_51 1321778.HMPREF1982_02841 6.72e-145 433.0 COG2268@1|root,COG2268@2|Bacteria,1TQDT@1239|Firmicutes,247MK@186801|Clostridia,268G1@186813|unclassified Clostridiales 186801|Clostridia S prohibitin homologues - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot k141_39_52 350688.Clos_1044 1.15e-26 107.0 COG1585@1|root,COG1585@2|Bacteria,1VD3E@1239|Firmicutes,24H38@186801|Clostridia,36IDP@31979|Clostridiaceae 186801|Clostridia OU Membrane protein implicated in regulation of membrane protease activity - - - - - - - - - - - - DUF1449,NfeD k141_39_54 411474.COPEUT_02789 1e-11 72.4 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia 186801|Clostridia C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k141_39_55 1347393.HG726025_gene2773 8.29e-279 802.0 COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,2FMC2@200643|Bacteroidia,4APPS@815|Bacteroidaceae 976|Bacteroidetes C Pyruvate formate lyase-like - - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k141_39_57 526218.Sterm_0367 1.37e-73 228.0 COG1418@1|root,COG1418@2|Bacteria 2|Bacteria S mRNA catabolic process yagB - - ko:K06950 - - - - ko00000 - - - HD k141_39_58 1226325.HMPREF1548_02115 8.89e-254 723.0 COG1479@1|root,COG1479@2|Bacteria,1TPAT@1239|Firmicutes,24CP3@186801|Clostridia,36H6W@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262,DUF4268 k141_39_61 1121324.CLIT_2c03700 1.24e-128 382.0 COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,25R9Z@186804|Peptostreptococcaceae 186801|Clostridia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C ## 2435 queries scanned ## Total time (seconds): 63.92450451850891 ## Rate: 38.09 q/s