## Thu Aug 29 16:00:12 2024
## emapper-2.1.12
## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/seagrass/mmseqs_cluster/PRJNA751983/SRR15353278/SRR15353278_p_cluster_rep_seq.fasta --output PRJNA751983_SRR15353278 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/seagrass/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
k141_1373_1	1200567.JNKD01000041_gene999	1.92e-32	126.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1Y5IS@135624|Aeromonadales	135624|Aeromonadales	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
k141_1080_1	138119.DSY4744	2.24e-11	68.2	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,263NB@186807|Peptococcaceae	186801|Clostridia	G	transporter, DctM subunit	-	-	-	ko:K21393	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctM
k141_1230_1	926549.KI421517_gene1492	1.55e-10	55.8	2EIJX@1|root,33CB7@2|Bacteria,4NY82@976|Bacteroidetes,47ST7@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_509_1	396588.Tgr7_0524	1.71e-23	105.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
k141_1804_1	43354.JOIJ01000004_gene3718	6.98e-29	118.0	COG1120@1|root,COG3576@1|root,COG1120@2|Bacteria,COG3576@2|Bacteria,2GJ49@201174|Actinobacteria,4DZQ8@85010|Pseudonocardiales	201174|Actinobacteria	HP	ABC-type cobalamin Fe3 -siderophore transport system, ATPase component	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran,FAD_binding_9,SIP
k141_940_1	584708.Apau_1667	5.23e-33	136.0	COG3598@1|root,COG4643@1|root,COG3598@2|Bacteria,COG4643@2|Bacteria,3TB49@508458|Synergistetes	508458|Synergistetes	L	TOPRIM	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25,Toprim_3
k141_354_1	880070.Cycma_4258	4.21e-43	155.0	COG0285@1|root,COG0285@2|Bacteria,4NES8@976|Bacteroidetes,47K0F@768503|Cytophagia	976|Bacteroidetes	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
k141_1231_2	1480694.DC28_03760	2.2e-11	65.1	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k141_76_1	1278307.KB906994_gene2863	4.87e-53	177.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae	1236|Gammaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_2105_1	1458357.BG58_13320	1.23e-11	70.1	COG1361@1|root,COG2373@1|root,COG2931@1|root,COG3210@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2VIZZ@28216|Betaproteobacteria,1K5XB@119060|Burkholderiaceae	28216|Betaproteobacteria	QU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,DUF4347
k141_1805_1	1120999.JONM01000003_gene2691	5.2e-47	157.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria,2KPCA@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
k141_355_1	314278.NB231_15223	5.62e-42	154.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1WXQY@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
k141_355_2	1123393.KB891316_gene1996	3.2e-32	114.0	COG0347@1|root,COG0347@2|Bacteria,1RIY4@1224|Proteobacteria,2VUG5@28216|Betaproteobacteria,1KT7V@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Nitrogen regulatory protein P-II	-	-	-	-	-	-	-	-	-	-	-	-	P-II
k141_796_1	768671.ThimaDRAFT_4891	1.06e-50	167.0	COG2963@1|root,COG2963@2|Bacteria,1QVMA@1224|Proteobacteria,1T2EF@1236|Gammaproteobacteria,1X2V5@135613|Chromatiales	135613|Chromatiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_796_2	977880.pRALTA_0248	3.96e-21	92.4	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria,1K6KM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
k141_941_1	506534.Rhein_3508	2.94e-64	212.0	COG0577@1|root,COG0577@2|Bacteria,1QSVW@1224|Proteobacteria,1RPBM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k141_1523_1	1121878.AUGL01000002_gene2311	1.84e-24	102.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k141_1523_2	582402.Hbal_0630	5.15e-52	179.0	COG0845@1|root,COG0845@2|Bacteria,1PVWV@1224|Proteobacteria,2TTJX@28211|Alphaproteobacteria,43Z45@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k141_1661_1	326442.PSHAa2061	7.56e-10	59.7	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,2Q18D@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
k141_1661_2	631362.Thi970DRAFT_02302	3.56e-31	122.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k141_1083_1	1238182.C882_0228	3.12e-88	287.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales	204441|Rhodospirillales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_1377_1	1185876.BN8_00772	5.72e-52	186.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,47MNQ@768503|Cytophagia	976|Bacteroidetes	O	SprB repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD,SprB,TIG
k141_214_1	439235.Dalk_1318	7.38e-16	72.8	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k141_356_1	387093.SUN_0243	3.4e-07	50.8	COG2010@1|root,COG2010@2|Bacteria,1RG22@1224|Proteobacteria,42NA2@68525|delta/epsilon subdivisions,2YN5N@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	cytochrome C	-	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
k141_356_2	395494.Galf_2472	5.73e-45	159.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,44WAP@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM cytochrome c oxidase subunit I	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k141_356_3	686340.Metal_0798	1.02e-05	46.6	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1XE9J@135618|Methylococcales	135618|Methylococcales	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
k141_651_1	177437.HRM2_36780	5.09e-70	229.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_512_1	713586.KB900536_gene339	3.37e-50	171.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1WVWC@135613|Chromatiales	135613|Chromatiales	K	TIGRFAM RNA polymerase sigma factor RpoS	rpoS	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k141_1233_1	710111.FraQA3DRAFT_5145	7.3e-32	126.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4ES4C@85013|Frankiales	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
k141_797_1	1283300.ATXB01000001_gene660	8.15e-158	452.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1XDX9@135618|Methylococcales	135618|Methylococcales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
k141_1961_1	1121403.AUCV01000003_gene1784	6.02e-33	130.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria,42X7Z@68525|delta/epsilon subdivisions,2WSMB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CHAD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
k141_357_1	1283079.M1IDW3_9CAUD	1.87e-22	101.0	4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses  no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae	10744|Podoviridae	S	DNA polymerase family A	-	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
k141_1662_1	1273711.A0A096VKH1_9CAUD	9.79e-170	489.0	4QF7H@10239|Viruses,4R06M@35237|dsDNA viruses  no RNA stage,4QQTS@28883|Caudovirales,4QNXE@10744|Podoviridae	10744|Podoviridae	S	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1526_1	314231.FP2506_04586	9.49e-17	81.3	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2TQQW@28211|Alphaproteobacteria,2PJH7@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
k141_1380_1	304371.MCP_2796	1.74e-31	127.0	arCOG06738@1|root,arCOG06738@2157|Archaea	2157|Archaea	O	extracellular matrix structural constituent	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	Beta_helix,Calx-beta,CarboxypepD_reg,NosD,Peptidase_S8
k141_1808_1	1123279.ATUS01000001_gene1633	1.11e-131	398.0	COG4772@1|root,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,1T302@1236|Gammaproteobacteria,1J5C6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k141_515_1	697282.Mettu_3106	6.81e-11	63.5	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,1XE21@135618|Methylococcales	135618|Methylococcales	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
k141_515_2	2340.JV46_17160	7.74e-24	101.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1J5M7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
k141_1527_1	984262.SGRA_1904	9.79e-112	351.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1INXI@117747|Sphingobacteriia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
k141_2110_1	391603.FBALC1_05078	1.34e-56	199.0	COG1361@1|root,COG5184@1|root,COG1361@2|Bacteria,COG5184@2|Bacteria,4NMB8@976|Bacteroidetes,1I065@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,He_PIG
k141_1809_1	1121405.dsmv_1703	3.74e-20	89.7	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k141_1809_2	875328.JDM601_1802	1.47e-09	60.1	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,2338A@1762|Mycobacteriaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
k141_2255_1	335992.SAR11_0932	2.72e-34	135.0	COG0726@1|root,COG2931@1|root,COG3209@1|root,COG3210@1|root,COG3391@1|root,COG0726@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1964_1	1089552.KI911559_gene1697	1.19e-62	216.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2JQIX@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
k141_1236_1	395493.BegalDRAFT_3133	5.46e-107	323.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,460AE@72273|Thiotrichales	72273|Thiotrichales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k141_82_1	329726.AM1_1621	6.67e-142	405.0	COG1024@1|root,COG1024@2|Bacteria,1GCQ1@1117|Cyanobacteria	1117|Cyanobacteria	I	enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k141_1382_1	926569.ANT_01510	3.75e-67	223.0	COG1132@1|root,COG1132@2|Bacteria,2G65H@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
k141_1237_1	326442.PSHAb0486	1.22e-76	254.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q46H@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k141_516_1	1123401.JHYQ01000003_gene2116	6.27e-38	140.0	COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
k141_516_2	1123399.AQVE01000004_gene2539	3.63e-52	181.0	COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	50S ribosome-binding GTPase	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
k141_1383_1	1167006.UWK_01633	2.71e-128	374.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,42MRB@68525|delta/epsilon subdivisions,2WIZD@28221|Deltaproteobacteria,2MIFB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type alpha subunit	dsrA	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
k141_1238_1	1499967.BAYZ01000152_gene1415	8.11e-35	129.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
k141_1966_1	292415.Tbd_2061	2.91e-11	63.5	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
k141_1966_2	292415.Tbd_2062	2.05e-37	138.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,1KRR9@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Glucokinase	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
k141_945_1	411460.RUMTOR_02880	3.86e-09	57.0	2ED6K@1|root,3373A@2|Bacteria,1VI2S@1239|Firmicutes,24QZV@186801|Clostridia,3Y0UX@572511|Blautia	186801|Clostridia	S	the current gene model (or a revised gene model) may contain one or more premature stops and or frameshifts	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1384_1	1123377.AUIV01000022_gene1998	2.15e-83	274.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,1RQ27@1236|Gammaproteobacteria,1X3W1@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
k141_1384_2	1000565.METUNv1_02355	5.07e-08	52.8	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,2KVF3@206389|Rhodocyclales	206389|Rhodocyclales	C	Respiratory nitrate reductase beta C-terminal	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
k141_85_1	519989.ECTPHS_05851	1.25e-73	232.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
k141_1668_1	1121104.AQXH01000002_gene747	1.39e-12	73.9	COG4447@1|root,COG4447@2|Bacteria,4NEJ8@976|Bacteroidetes,1IXY7@117747|Sphingobacteriia	976|Bacteroidetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,MAM,TIG,fn3
k141_358_2	113355.CM001775_gene3188	1.4e-26	99.0	2DNQR@1|root,32YKU@2|Bacteria,1G9K3@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_658_1	644107.SL1157_0337	4.93e-55	173.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2U5JQ@28211|Alphaproteobacteria,4NC92@97050|Ruegeria	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	MA20_20490	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
k141_658_2	1454004.AW11_01557	3.37e-23	94.7	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2VRAJ@28216|Betaproteobacteria,1KR43@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Putative FMN-binding domain	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
k141_1239_1	225937.HP15_2344	1.07e-77	246.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,4653T@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	fadI	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k141_1531_1	1313172.YM304_26020	4.39e-84	263.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
k141_805_1	305900.GV64_12675	1.95e-133	387.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RQDY@1236|Gammaproteobacteria,1XI09@135619|Oceanospirillales	135619|Oceanospirillales	S	Cobalamin synthesis protein P47K	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k141_1814_1	566466.NOR53_3097	2.01e-101	306.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J8WR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iPC815.YPO3971,iSDY_1059.SDY_1514,iYL1228.KPN_01210,iZ_1308.Z2793	ELFV_dehydrog,ELFV_dehydrog_N
k141_1386_1	1541065.JRFE01000004_gene5309	1.23e-78	240.0	COG3385@1|root,COG3385@2|Bacteria,1GKZQ@1117|Cyanobacteria,3VN9P@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
k141_519_1	1239962.C943_00454	1.47e-69	222.0	COG3177@1|root,COG3177@2|Bacteria,4NFBY@976|Bacteroidetes,47MWT@768503|Cytophagia	976|Bacteroidetes	K	PFAM Fic DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
k141_946_2	1044.EH31_10370	1.02e-92	293.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2KDC9@204457|Sphingomonadales	204457|Sphingomonadales	MU	Outer membrane efflux protein	-	-	-	ko:K18903	-	M00698	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17.3.3	-	-	OEP
k141_660_1	555779.Dthio_PD2895	6.62e-35	129.0	COG0582@1|root,COG0582@2|Bacteria,1RCN8@1224|Proteobacteria,42RD9@68525|delta/epsilon subdivisions,2WMVF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	viral genome integration into host DNA	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
k141_806_1	1121271.AUCM01000011_gene1981	0.000216	47.4	COG0454@1|root,COG0456@2|Bacteria,1N1SU@1224|Proteobacteria,2UA9R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
k141_1815_1	713587.THITH_02750	2.86e-71	230.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k141_1220_1	397291.C804_00124	2.05e-31	115.0	COG0139@1|root,COG0139@2|Bacteria	2|Bacteria	E	phosphoribosyl-AMP cyclohydrolase activity	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
k141_200_1	1122194.AUHU01000002_gene2513	6.36e-41	151.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RNTQ@1236|Gammaproteobacteria,467P9@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	TAP-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
k141_200_2	521460.Athe_1706	1.1e-07	52.8	COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,25B0Q@186801|Clostridia,42HS7@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k141_1795_1	1120956.JHZK01000034_gene2050	4.16e-70	234.0	COG0129@1|root,COG0363@1|root,COG0129@2|Bacteria,COG0363@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,1JNQ4@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Dehydratase family	-	-	4.2.1.82	ko:K22186	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
k141_1071_1	69042.WH5701_01855	6.69e-101	310.0	COG5361@1|root,COG5361@2|Bacteria,1G1YW@1117|Cyanobacteria,1GYS9@1129|Synechococcus	1117|Cyanobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k141_1512_1	1121127.JAFA01000008_gene5903	4.68e-07	52.4	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1JZYF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
k141_1512_2	1122236.KB905141_gene1110	1.64e-19	87.8	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,2KMB4@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
k141_1796_1	1211115.ALIQ01000171_gene4105	2.88e-47	155.0	COG2164@1|root,COG2164@2|Bacteria,1RCY5@1224|Proteobacteria,2U5NN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3830)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3830
k141_1796_2	358220.C380_00790	7.15e-23	94.7	COG0384@1|root,COG0384@2|Bacteria,1MYCV@1224|Proteobacteria,2W03S@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
k141_64_1	395493.BegalDRAFT_0212	1.9e-94	289.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k141_786_2	1123487.KB892837_gene3986	1.18e-62	202.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,2KVZB@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
k141_201_1	1089550.ATTH01000001_gene855	3.31e-12	66.6	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,Guanylate_cyc
k141_201_2	1049564.TevJSym_ab01230	9.29e-62	199.0	COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
k141_346_1	1122603.ATVI01000008_gene2454	2.82e-81	248.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
k141_1223_2	1123354.AUDR01000013_gene704	4.6e-43	149.0	2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,2VN2M@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1072_1	1121447.JONL01000022_gene3718	1.42e-37	128.0	2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria,42WB2@68525|delta/epsilon subdivisions,2WWEJ@28221|Deltaproteobacteria,2MFC3@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1514_1	1033802.SSPSH_002207	0.000118	47.4	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
k141_933_1	396595.TK90_2183	1.27e-99	300.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_347_1	177437.HRM2_39610	4.7e-25	101.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,42S14@68525|delta/epsilon subdivisions,2WNUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
k141_1073_1	1380391.JIAS01000012_gene4198	2.75e-10	65.9	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2TTBW@28211|Alphaproteobacteria,2JZN7@204441|Rhodospirillales	204441|Rhodospirillales	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_788_1	305900.GV64_07400	3.14e-78	261.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XHXU@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_348_1	983545.Glaag_1018	1.58e-06	51.6	COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria,46D3A@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Mechanosensitive ion channel	mscS	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
k141_934_1	349521.HCH_06009	1.23e-85	262.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1XIV0@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
k141_67_1	1123020.AUIE01000035_gene5291	2.63e-10	61.2	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1YDWM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Metallo-beta-lactamase superfamily	blh	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
k141_67_2	318167.Sfri_3903	1.95e-51	178.0	COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria,2QAI5@267890|Shewanellaceae	1236|Gammaproteobacteria	K	Transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3612,HTH_19,HTH_3,Peptidase_M78
k141_1952_1	1120970.AUBZ01000003_gene155	1.45e-14	70.9	2EG7N@1|root,339ZH@2|Bacteria,1NJ6P@1224|Proteobacteria,1SI7V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Kazal_1
k141_1952_2	313595.P700755_001541	3.66e-13	69.3	COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia,4C33D@83612|Psychroflexus	976|Bacteroidetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
k141_789_1	227377.CBU_2096	0.00013	44.3	29Q4T@1|root,32BQP@2|Bacteria,1N5SH@1224|Proteobacteria,1T0CB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
k141_503_2	313628.LNTAR_09801	3.09e-58	193.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.12	ko:K01135,ko:K01138	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00077	R07823	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Sulfatase
k141_1225_1	243090.RB4725	6.47e-119	347.0	COG1028@1|root,COG1028@2|Bacteria,2J0Y9@203682|Planctomycetes	203682|Planctomycetes	IQ	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_644_1	869213.JCM21142_31268	8.03e-42	137.0	COG0361@1|root,COG0361@2|Bacteria,4NS6S@976|Bacteroidetes,47RFD@768503|Cytophagia	976|Bacteroidetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
k141_644_2	1392490.JHZX01000001_gene1092	1.12e-64	209.0	COG0201@1|root,COG0201@2|Bacteria,4NEPU@976|Bacteroidetes,1HWR7@117743|Flavobacteriia	976|Bacteroidetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
k141_68_1	71139.XP_010065643.1	3.85e-06	50.8	COG0196@1|root,COG0637@1|root,KOG2914@2759|Eukaryota,KOG3110@2759|Eukaryota,37K0I@33090|Viridiplantae,3G8YV@35493|Streptophyta	35493|Streptophyta	H	riboflavin kinase	-	GO:0000287,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0006915,GO:0006950,GO:0008150,GO:0008152,GO:0008219,GO:0008531,GO:0009611,GO:0009893,GO:0009987,GO:0012501,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019222,GO:0033860,GO:0033864,GO:0042060,GO:0042578,GO:0043085,GO:0043167,GO:0043169,GO:0044093,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0048518,GO:0050789,GO:0050790,GO:0050896,GO:0051341,GO:0051353,GO:0065007,GO:0065009,GO:0070566,GO:0072593	2.7.1.26,3.1.3.102	ko:K20884	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavokinase,HAD_2
k141_205_1	985867.AEWF01000006_gene496	2.22e-42	141.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,2U8PC@28211|Alphaproteobacteria,47G6G@766|Rickettsiales	766|Rickettsiales	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1800_1	1168034.FH5T_06865	4.97e-19	91.7	COG2304@1|root,COG3291@1|root,COG3391@1|root,COG2304@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K17285,ko:K20274,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002,ko04147	-	-	-	VWA,VWA_2
k141_1075_1	1328313.DS2_06856	5.03e-26	108.0	28HPB@1|root,2Z7XC@2|Bacteria,1MVUK@1224|Proteobacteria,1RQN9@1236|Gammaproteobacteria,4652N@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Heparinase II/III-like protein	-	-	4.2.2.26	ko:K20525	-	-	-	-	ko00000,ko01000	-	-	-	Alginate_lyase,Hepar_II_III
k141_1075_2	592029.DDD_0337	1.08e-12	68.6	COG5434@1|root,COG5434@2|Bacteria,4NIEJ@976|Bacteroidetes,1I03C@117743|Flavobacteriia,3HKY4@363408|Nonlabens	976|Bacteroidetes	M	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Pectate_lyase_3
k141_1370_1	575540.Isop_3152	1.72e-84	271.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
k141_69_1	1121447.JONL01000010_gene2381	6.66e-37	140.0	COG1262@1|root,COG1262@2|Bacteria,1R6GS@1224|Proteobacteria,42R3Z@68525|delta/epsilon subdivisions,2WN4D@28221|Deltaproteobacteria,2MGMW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
k141_1226_1	583345.Mmol_0783	4.19e-34	136.0	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG5184@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG5184@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNPI@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VWA_2
k141_1654_1	595460.RRSWK_00869	9.72e-08	60.1	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_936_1	1227739.Hsw_2333	8.19e-123	377.0	COG1913@1|root,COG1913@2|Bacteria,4PMAZ@976|Bacteroidetes,47JTT@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
k141_645_1	35128.Thapsdraft2088	1.68e-228	637.0	COG1850@1|root,2QTI9@2759|Eukaryota,2XE5R@2836|Bacillariophyta	2836|Bacillariophyta	Q	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
k141_1077_1	391615.ABSJ01000033_gene697	6.3e-85	268.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iSFV_1184.SFV_1868	GAD,tRNA-synt_2,tRNA_anti-codon
k141_1655_1	1121033.AUCF01000001_gene2064	1.08e-16	84.7	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria,2JRKA@204441|Rhodospirillales	204441|Rhodospirillales	P	Na+/Pi-cotransporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_Pi_cotrans
k141_1955_1	1210884.HG799465_gene11459	1.18e-48	161.0	COG2940@1|root,COG2940@2|Bacteria,2J0I6@203682|Planctomycetes	203682|Planctomycetes	S	Cysteine-rich motif following a subset of SET domains	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
k141_1955_2	670292.JH26_13440	1.99e-12	66.6	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,1JU6K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k141_209_1	292459.STH3235	4.23e-72	243.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
k141_938_1	501479.ACNW01000086_gene3918	1.17e-25	109.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
k141_647_1	1167006.UWK_00221	9.24e-100	310.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MIDU@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
k141_1079_1	1122599.AUGR01000005_gene1973	6.08e-66	216.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,1XK8Z@135619|Oceanospirillales	135619|Oceanospirillales	E	Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
k141_1229_1	760142.Hipma_0933	2.82e-06	47.4	COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria,2M7GD@213113|Desulfurellales	28221|Deltaproteobacteria	J	Ribosomal L28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
k141_939_1	1172188.KB911829_gene4447	8.02e-66	210.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4FG07@85021|Intrasporangiaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
k141_2008_1	1432050.IE4771_CH01828	1.26e-51	183.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
k141_845_1	1206101.AZXC01000023_gene2986	2.35e-49	171.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k141_258_1	765913.ThidrDRAFT_1843	5.52e-116	339.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,1T1Q3@1236|Gammaproteobacteria,1WXCI@135613|Chromatiales	135613|Chromatiales	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k141_121_1	1123514.KB905901_gene121	5.2e-42	151.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,1RN0G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
k141_1276_2	1122604.JONR01000015_gene102	6.52e-51	173.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X4F6@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
k141_398_1	1173024.KI912149_gene5528	3.13e-24	103.0	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1JKNQ@1189|Stigonemataceae	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
k141_1533_1	999411.HMPREF1092_02542	3.37e-86	268.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,36E04@31979|Clostridiaceae	186801|Clostridia	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
k141_1671_1	926556.Echvi_1013	2.2e-39	148.0	COG0783@1|root,COG3039@1|root,COG0783@2|Bacteria,COG3039@2|Bacteria,4NI06@976|Bacteroidetes,47WK3@768503|Cytophagia	976|Bacteroidetes	LP	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF772
k141_1971_1	1280001.BAOA01000033_gene2227	7.48e-34	118.0	2DMHR@1|root,32RMI@2|Bacteria,1QK1W@1224|Proteobacteria,1TI4F@1236|Gammaproteobacteria,1XYCQ@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1094_1	247634.GPB2148_170	3.14e-28	105.0	COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria	1224|Proteobacteria	L	COG2963, Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k141_1094_2	247634.GPB2148_14	2.08e-31	119.0	COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	2.7.7.49	ko:K00986,ko:K07497	-	-	-	-	ko00000,ko01000	-	-	-	HTH_32,rve,rve_3
k141_224_1	1380355.JNIJ01000012_gene1020	6.16e-50	175.0	COG0330@1|root,COG0330@2|Bacteria,1RE9F@1224|Proteobacteria,2U91D@28211|Alphaproteobacteria,3K3X1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k141_522_1	1382230.ASAP_2763	1.64e-25	103.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1389_1	1565314.OA34_09220	8.08e-08	59.3	COG5001@1|root,COG5001@2|Bacteria,1QR8J@1224|Proteobacteria,42ZBG@68525|delta/epsilon subdivisions,2YR24@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
k141_1672_1	1121405.dsmv_1436	2.9e-215	607.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k141_1390_1	1123372.AUIT01000040_gene1026	2.49e-08	58.9	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9,Protoglobin
k141_1242_2	1121898.Q766_14790	2.65e-20	88.6	COG0745@1|root,COG0745@2|Bacteria,4NE77@976|Bacteroidetes,1IMIZ@117743|Flavobacteriia,2P0FV@237|Flavobacterium	976|Bacteroidetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
k141_1819_1	1168065.DOK_02271	2.09e-18	85.9	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,1JAZZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
k141_1819_2	1122918.KB907260_gene2007	1.42e-10	61.6	COG2197@1|root,COG2197@2|Bacteria,1V2YB@1239|Firmicutes,4HFUE@91061|Bacilli,26SI6@186822|Paenibacillaceae	91061|Bacilli	KT	LuxR family transcriptional regulator	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
k141_1096_1	1313172.YM304_14270	5.05e-99	296.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia	84992|Acidimicrobiia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
k141_1974_1	1380387.JADM01000002_gene2294	6.47e-75	228.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1XI52@135619|Oceanospirillales	135619|Oceanospirillales	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
k141_1820_1	1500301.JQMF01000003_gene4288	1.55e-22	100.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2TU9Q@28211|Alphaproteobacteria,4BDJD@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k141_812_1	1121935.AQXX01000109_gene480	1.07e-65	223.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
k141_665_1	1167006.UWK_01467	3.24e-69	221.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MMPC@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM Type II IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k141_88_1	1255043.TVNIR_0754	1.58e-241	697.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales	135613|Chromatiales	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
k141_1539_1	83219.PM02_12705	9.76e-122	371.0	COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3ZW8Y@60136|Sulfitobacter	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
k141_952_1	435908.IDSA_05880	3.93e-63	214.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,2QF9T@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k141_1392_2	631454.N177_0502	3.3e-59	198.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,1JNPA@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_43210	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k141_1244_1	95619.PM1_0205730	3.32e-05	51.2	COG5148@1|root,COG5148@2|Bacteria,1QTZE@1224|Proteobacteria,1RY3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k141_2124_1	1120965.AUBV01000015_gene1141	1.39e-30	125.0	COG3291@1|root,COG4935@1|root,COG5184@1|root,COG3291@2|Bacteria,COG4935@2|Bacteria,COG5184@2|Bacteria,4NDZC@976|Bacteroidetes,47SFQ@768503|Cytophagia	976|Bacteroidetes	O	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cu-binding_MopE,DUF11,HYR,Laminin_G_3,PKD,SprB
k141_225_2	27923.ML14631a-PA	2.97e-62	207.0	COG2801@1|root,KOG0017@2759|Eukaryota,39ZX7@33154|Opisthokonta,3BQ45@33208|Metazoa	33208|Metazoa	H	Ribonuclease H protein	-	-	-	-	-	-	-	-	-	-	-	-	Chromo,rve
k141_1675_1	1502850.FG91_00923	1.48e-21	92.8	COG2188@1|root,COG2188@2|Bacteria,1MVFM@1224|Proteobacteria,2U7HX@28211|Alphaproteobacteria,2K3PJ@204457|Sphingomonadales	204457|Sphingomonadales	K	UTRA domain	-	-	-	ko:K05836	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
k141_1675_2	1276756.AUEX01000002_gene456	3.66e-37	137.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2VK3E@28216|Betaproteobacteria,4ABE7@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
k141_367_1	316279.Syncc9902_2036	2.61e-82	252.0	2DBBD@1|root,2Z87P@2|Bacteria,1G08A@1117|Cyanobacteria,1GYWQ@1129|Synechococcus	1117|Cyanobacteria	C	Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors	psbA2	-	1.10.3.9	ko:K02703	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Photo_RC
k141_1822_1	998674.ATTE01000001_gene470	9.42e-34	132.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,45ZTE@72273|Thiotrichales	72273|Thiotrichales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k141_953_1	414684.RC1_2187	6.29e-81	251.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JPG4@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k141_1976_1	1286106.MPL1_01687	5.76e-40	147.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
k141_814_1	979556.MTES_1958	2.77e-69	229.0	COG3534@1|root,COG3534@2|Bacteria,2GMAK@201174|Actinobacteria,4FMQR@85023|Microbacteriaceae	201174|Actinobacteria	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
k141_667_1	1123228.AUIH01000001_gene1272	5.68e-72	238.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XHE2@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
k141_1677_1	472759.Nhal_2570	4.11e-47	171.0	COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1WYRI@135613|Chromatiales	135613|Chromatiales	P	TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_1542_1	261292.Nit79A3_3309	1.16e-39	141.0	COG1988@1|root,COG1988@2|Bacteria,1PCAC@1224|Proteobacteria,2WFID@28216|Betaproteobacteria,372P9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
k141_91_1	396588.Tgr7_2615	5.41e-122	376.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales	135613|Chromatiales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k141_526_1	1121878.AUGL01000002_gene2311	1.56e-152	462.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k141_1100_1	765911.Thivi_0686	1.07e-26	109.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1WWDC@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
k141_668_1	1123320.KB889721_gene7468	6.66e-06	54.3	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2IBMM@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
k141_956_1	1552758.NC00_13875	1.6e-71	240.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales	135614|Xanthomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k141_1396_1	1123248.KB893337_gene2561	4.79e-37	144.0	COG3210@1|root,COG4932@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,Calx-beta,Cna_B,Collagen_bind,Glug,Gram_pos_anchor,He_PIG,PATR,SLH,VWA_2,YSIRK_signal
k141_1978_1	1589298.A0A0B5H8S2_9CAUD	0.000192	49.3	4QAIK@10239|Viruses	10239|Viruses	S	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_957_2	981223.AIED01000032_gene3653	2.75e-52	181.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,3NK5E@468|Moraxellaceae	1236|Gammaproteobacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093	Mur_ligase,Mur_ligase_C,Mur_ligase_M
k141_371_1	298386.PBPRA0960	4.27e-48	162.0	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,1Y2D5@135623|Vibrionales	135623|Vibrionales	K	Belongs to the sigma-70 factor family. ECF subfamily	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
k141_1544_1	1232437.KL661964_gene3327	1.2e-57	196.0	COG0389@1|root,COG1254@1|root,COG0389@2|Bacteria,COG1254@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MHKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
k141_1102_1	105559.Nwat_1994	1.68e-91	279.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
k141_1249_1	195250.CM001776_gene3946	3.16e-12	71.6	COG2931@1|root,COG4254@1|root,COG2931@2|Bacteria,COG4254@2|Bacteria,1GJ0A@1117|Cyanobacteria,1H18T@1129|Synechococcus	1117|Cyanobacteria	Q	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k141_94_1	1123037.AUDE01000023_gene2747	1.75e-32	117.0	COG0526@1|root,COG0526@2|Bacteria,4NNHX@976|Bacteroidetes,1I33N@117743|Flavobacteriia	976|Bacteroidetes	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
k141_1979_1	497321.C664_14029	5.01e-21	92.4	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KVNP@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k141_1397_1	178901.AmDm5_0028	3.07e-10	60.1	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2JQ57@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
k141_1397_2	998674.ATTE01000001_gene1801	7.6e-105	309.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
k141_529_1	1121396.KB893078_gene786	8.01e-56	190.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria	1224|Proteobacteria	S	Involved in initiation control of chromosome replication	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
k141_670_1	3075.A0A087SSR9	2.08e-23	107.0	COG0519@1|root,KOG1622@2759|Eukaryota,37KGG@33090|Viridiplantae,34HAJ@3041|Chlorophyta	3041|Chlorophyta	F	GMP synthase C terminal domain	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
k141_1827_1	118161.KB235922_gene3085	1.81e-08	54.3	28N9H@1|root,2ZBDH@2|Bacteria,1G5CA@1117|Cyanobacteria,3VI09@52604|Pleurocapsales	1117|Cyanobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,Viral_helicase1
k141_1827_2	489825.LYNGBM3L_00450	1.03e-127	366.0	COG0639@1|root,COG0639@2|Bacteria,1G0PE@1117|Cyanobacteria,1H8WR@1150|Oscillatoriales	1117|Cyanobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
k141_819_1	768671.ThimaDRAFT_4890	9.92e-65	209.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,1RQ7I@1236|Gammaproteobacteria,1WWFP@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve
k141_959_1	1366050.N234_36435	2.68e-34	125.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k141_959_2	697282.Mettu_2592	3.94e-66	212.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria,1XETG@135618|Methylococcales	1236|Gammaproteobacteria	S	PFAM Transposase, IS801 IS1294	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k141_1104_1	946483.Cenrod_1878	7.85e-52	167.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,4ADW1@80864|Comamonadaceae	28216|Betaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
k141_1546_1	1256908.HMPREF0373_02517	2.43e-05	46.2	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia,25X5I@186806|Eubacteriaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
k141_1398_1	130081.XP_005708643.1	3.04e-21	89.0	2E3A4@1|root,2SADZ@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1828_1	1370121.AUWS01000073_gene973	1.51e-11	63.9	COG2057@1|root,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,2356Z@1762|Mycobacteriaceae	201174|Actinobacteria	I	transferase	pcaJ	-	2.8.3.5	ko:K01027,ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
k141_1828_2	425104.Ssed_3708	2.81e-52	178.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1SM2G@1236|Gammaproteobacteria,2QAAP@267890|Shewanellaceae	1236|Gammaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
k141_96_1	565045.NOR51B_2860	5.31e-27	106.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Hydrolase	yrfG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
k141_1682_2	1230338.MOMA_04015	8.81e-32	119.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,3NJTB@468|Moraxellaceae	1236|Gammaproteobacteria	P	Belongs to the Fur family	zur	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
k141_1105_1	1454004.AW11_03211	3.08e-64	207.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k141_1780_1	690597.JH730935_gene3255	6.59e-24	100.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,1YSFY@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Iron-hydroxamate ABC transporter substrate-binding protein	btuF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169	Peripla_BP_2
k141_1780_2	935567.JAES01000005_gene533	2.5e-13	67.4	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales	135614|Xanthomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
k141_1058_1	720555.BATR1942_08180	1.14e-06	55.5	COG0596@1|root,COG0596@2|Bacteria,1UZP1@1239|Firmicutes,4HBKV@91061|Bacilli,1ZE0T@1386|Bacillus	91061|Bacilli	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
k141_485_1	84531.JMTZ01000006_gene3528	4.05e-77	251.0	COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales	135614|Xanthomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k141_1251_2	1123392.AQWL01000003_gene448	3.32e-16	79.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria,1MUHS@1224|Proteobacteria,2VIGN@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c
k141_530_1	472759.Nhal_0727	2.75e-30	122.0	COG0745@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	fixL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
k141_530_2	1121289.JHVL01000009_gene1433	7.07e-05	48.9	COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,36FX7@31979|Clostridiaceae	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
k141_1547_1	526227.Mesil_1547	4.3e-55	181.0	COG0410@1|root,COG0410@2|Bacteria,1WIEV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k141_1547_2	1265505.ATUG01000001_gene4060	2.58e-32	119.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42N2W@68525|delta/epsilon subdivisions,2WJRB@28221|Deltaproteobacteria,2MJD8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
k141_961_1	1244869.H261_12589	3.21e-23	97.8	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2U3B7@28211|Alphaproteobacteria,2JW9V@204441|Rhodospirillales	204441|Rhodospirillales	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
k141_961_2	396588.Tgr7_2195	6.77e-42	144.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_7
k141_1829_1	1116472.MGMO_50c00050	4.3e-79	253.0	COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,1TA9S@1236|Gammaproteobacteria,1XGT0@135618|Methylococcales	135618|Methylococcales	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
k141_1106_1	714961.BFZC1_07208	6.86e-60	192.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,3IX5U@400634|Lysinibacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
k141_97_1	421052.F945_03092	8.54e-07	52.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1S4HN@1236|Gammaproteobacteria,3NIJU@468|Moraxellaceae	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k141_97_2	765420.OSCT_0207	2.82e-29	117.0	COG0747@1|root,COG0747@2|Bacteria,2G85H@200795|Chloroflexi,3773I@32061|Chloroflexia	32061|Chloroflexia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k141_1830_1	279714.FuraDRAFT_1413	4.19e-82	251.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,2KPSF@206351|Neisseriales	206351|Neisseriales	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
k141_1252_1	105559.Nwat_2820	1.01e-77	242.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,1RQAT@1236|Gammaproteobacteria,1WWZM@135613|Chromatiales	135613|Chromatiales	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
k141_98_1	391587.KAOT1_19837	1.9e-30	122.0	COG1538@1|root,COG1538@2|Bacteria,4NEEN@976|Bacteroidetes,1HWPI@117743|Flavobacteriia	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
k141_674_1	391619.PGA1_c18040	7.12e-06	48.9	COG1028@1|root,COG1028@2|Bacteria,1RA3U@1224|Proteobacteria,2U640@28211|Alphaproteobacteria,34G9S@302485|Phaeobacter	28211|Alphaproteobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
k141_674_2	1217718.ALOU01000022_gene2361	1.83e-31	115.0	COG0662@1|root,COG0662@2|Bacteria,1N1YZ@1224|Proteobacteria,2VU48@28216|Betaproteobacteria,1K9YZ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k141_375_1	177439.DP1357	5.34e-132	387.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2MIYC@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
k141_1401_1	1123279.ATUS01000002_gene48	5.57e-62	199.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1J4UT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
k141_1549_1	491952.Mar181_2033	6.28e-18	84.7	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XNWJ@135619|Oceanospirillales	135619|Oceanospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.77	ko:K03851	ko00430,ko01100,map00430,map01100	-	R05652	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
k141_822_1	1123035.ARLA01000028_gene1764	2.43e-16	86.3	COG1361@1|root,COG1524@1|root,COG2866@1|root,COG1361@2|Bacteria,COG1524@2|Bacteria,COG2866@2|Bacteria,4PPPD@976|Bacteroidetes	976|Bacteroidetes	E	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_99_1	929556.Solca_0050	1.16e-19	93.2	COG1470@1|root,COG3209@1|root,COG4932@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia	976|Bacteroidetes	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SprB
k141_1108_1	768066.HELO_2318	1.46e-30	119.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,1S2KI@1236|Gammaproteobacteria,1XKWA@135619|Oceanospirillales	135619|Oceanospirillales	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
k141_1831_1	6087.XP_004208064.1	2.09e-56	203.0	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k141_823_1	1142394.PSMK_29200	1.85e-34	134.0	COG0178@1|root,COG0178@2|Bacteria,2IXFK@203682|Planctomycetes	203682|Planctomycetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
k141_1402_1	1123037.AUDE01000049_gene840	5.87e-12	59.3	2EJCW@1|root,33D3W@2|Bacteria,4NYSH@976|Bacteroidetes,1I6SV@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1832_1	1121935.AQXX01000127_gene1162	3.77e-22	101.0	COG0747@1|root,COG3210@1|root,COG0747@2|Bacteria,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,1T32K@1236|Gammaproteobacteria,1XMGN@135619|Oceanospirillales	135619|Oceanospirillales	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1687_1	1005395.CSV86_05661	7.02e-13	68.6	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,1RRV4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
k141_1687_2	1122603.ATVI01000005_gene3731	1.36e-11	66.6	COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,1RQNB@1236|Gammaproteobacteria,1X8RR@135614|Xanthomonadales	135614|Xanthomonadales	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
k141_1403_2	1297863.APJF01000016_gene4197	1.57e-16	77.0	COG5500@1|root,COG5500@2|Bacteria,1N0PP@1224|Proteobacteria,2U7MA@28211|Alphaproteobacteria,3JYWD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1772)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1772
k141_824_1	467661.RKLH11_3598	3.41e-134	394.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3ZI0G@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_43210	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
k141_1550_1	616991.JPOO01000003_gene903	1.51e-77	232.0	2EBGV@1|root,335HF@2|Bacteria,4NV5E@976|Bacteroidetes,1I6Q2@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1111_1	1121124.JNIX01000008_gene2430	5.17e-39	148.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria,2KK8I@204458|Caulobacterales	204458|Caulobacterales	H	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_101_1	261292.Nit79A3_0212	1.01e-58	202.0	COG3385@1|root,COG3385@2|Bacteria,1RA6A@1224|Proteobacteria,2VUMQ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_4
k141_534_1	1487923.DP73_10970	3.34e-05	45.8	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia	186801|Clostridia	O	SPFH Band 7 PHB domain protein	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k141_534_2	336407.RBE_1172	8.3e-24	106.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,47EUY@766|Rickettsiales	766|Rickettsiales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
k141_379_1	396588.Tgr7_0745	1.62e-21	92.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k141_379_2	998674.ATTE01000001_gene642	6.58e-67	216.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,460BB@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
k141_1257_1	391626.OAN307_c03800	2.22e-68	219.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
k141_966_1	768671.ThimaDRAFT_4347	2.7e-90	274.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1WXTT@135613|Chromatiales	135613|Chromatiales	K	PFAM HTH transcriptional regulator, LysR	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
k141_1988_1	1304875.JAFZ01000002_gene393	3.44e-48	174.0	COG0841@1|root,COG0841@2|Bacteria,3T9T3@508458|Synergistetes	508458|Synergistetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_1988_2	1136138.JH604624_gene4066	0.000801	42.7	COG0845@1|root,COG0845@2|Bacteria,1R4GC@1224|Proteobacteria,1S2M2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K21137	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
k141_1689_1	1121403.AUCV01000066_gene4154	9.91e-149	427.0	COG3385@1|root,COG3385@2|Bacteria,1RM2A@1224|Proteobacteria,42WE3@68525|delta/epsilon subdivisions,2X6QW@28221|Deltaproteobacteria,2MN97@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k141_677_2	998674.ATTE01000001_gene4344	1.99e-122	358.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,46040@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
k141_1406_1	1218084.BBJK01000149_gene7525	8.67e-95	288.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae	28216|Betaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
k141_967_1	443152.MDG893_04067	6.82e-35	121.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,4682T@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
k141_241_1	583355.Caka_2787	3.19e-71	223.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2,DUF4437,Haem_oxygenas_2,KduI
k141_1259_1	981327.F925_01327	3.47e-63	208.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,3NIEX@468|Moraxellaceae	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k141_1990_2	626887.J057_13953	9e-40	146.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,4648C@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k141_1115_1	1265503.KB905166_gene704	2.37e-31	115.0	2AHKF@1|root,317Y8@2|Bacteria,1P9Y5@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
k141_968_1	880072.Desac_0364	1.46e-11	67.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2MQBT@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k141_968_2	506534.Rhein_1765	3.89e-36	135.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T3TQ@1236|Gammaproteobacteria,1X2RZ@135613|Chromatiales	135613|Chromatiales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_242_1	2340.JV46_02560	4.03e-32	114.0	2BTD9@1|root,32NJ9@2|Bacteria,1RJF8@1224|Proteobacteria,1S7B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1838_1	1118058.CAGY01000008_gene1460	3.01e-39	147.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria,4D4XQ@85005|Actinomycetales	201174|Actinobacteria	P	transporter, permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
k141_381_1	391625.PPSIR1_13345	4.33e-35	136.0	COG4102@1|root,COG4102@2|Bacteria,1RG65@1224|Proteobacteria,4376H@68525|delta/epsilon subdivisions,2X49E@28221|Deltaproteobacteria,2YYJB@29|Myxococcales	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
k141_1991_1	1123261.AXDW01000001_gene1306	1.16e-55	178.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1X3UG@135614|Xanthomonadales	135614|Xanthomonadales	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
k141_1116_1	998674.ATTE01000001_gene1099	1.44e-74	236.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,45ZSV@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k141_969_1	1442599.JAAN01000031_gene1386	1.93e-104	322.0	COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,1RS2Q@1236|Gammaproteobacteria,1X3UN@135614|Xanthomonadales	135614|Xanthomonadales	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
k141_539_1	2340.JV46_04040	7.97e-53	181.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1J4KT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k141_382_1	1116472.MGMO_120c00590	9.51e-41	144.0	COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,1S566@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
k141_1992_1	981369.JQMJ01000004_gene6178	3.5e-12	71.6	COG4585@1|root,COG4585@2|Bacteria,2GNBG@201174|Actinobacteria,2NH17@228398|Streptacidiphilus	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
k141_1262_1	1380600.AUYN01000009_gene1343	1.28e-105	319.0	COG0138@1|root,COG0138@2|Bacteria,4NEZD@976|Bacteroidetes,1HXDR@117743|Flavobacteriia	976|Bacteroidetes	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
k141_1693_1	1089552.KI911559_gene2173	4.09e-95	285.0	COG2113@1|root,COG2113@2|Bacteria,1MVXS@1224|Proteobacteria,2TUFF@28211|Alphaproteobacteria,2JZKU@204441|Rhodospirillales	204441|Rhodospirillales	E	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
k141_244_1	94624.Bpet4513	2.47e-31	122.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria,3T3EX@506|Alcaligenaceae	28216|Betaproteobacteria	E	Homoserine dehydrogenase, NAD binding domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
k141_831_1	626522.GCWU000325_02079	8.23e-38	144.0	COG3385@1|root,COG3385@2|Bacteria,4NX1P@976|Bacteroidetes,2FPSY@200643|Bacteroidia	976|Bacteroidetes	L	COG COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
k141_496_1	1121875.KB907547_gene3094	4.33e-75	245.0	COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,1HXBI@117743|Flavobacteriia	976|Bacteroidetes	G	hydrolase, family 65, central catalytic	-	-	2.4.1.8	ko:K00691	ko00500,ko01100,map00500,map01100	-	R01555	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
k141_637_2	479432.Sros_6124	4.84e-05	46.6	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4EGYP@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
k141_1070_2	85643.Tmz1t_4040	6.34e-81	255.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VHIG@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
k141_343_1	1122194.AUHU01000003_gene2009	1.47e-12	67.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,467AN@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
k141_343_2	322710.Avin_47370	2.48e-27	106.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
k141_613_1	1089551.KE386572_gene2253	1.68e-31	127.0	COG1680@1|root,COG1680@2|Bacteria,1MWHS@1224|Proteobacteria,2UCGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
k141_1046_1	1215092.PA6_020_00340	1.41e-83	261.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1YDVX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Putative modulator of DNA gyrase	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
k141_320_1	519989.ECTPHS_13203	8.08e-69	226.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
k141_320_2	105559.Nwat_2184	2.72e-73	230.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_474_1	383372.Rcas_2445	1.81e-17	84.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
k141_1627_1	926550.CLDAP_06970	8.89e-72	234.0	COG0589@1|root,COG1215@1|root,COG0589@2|Bacteria,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266,2.4.1.268	ko:K09118,ko:K13693,ko:K21349	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2,Usp
k141_2064_1	69328.PVLB_00930	1.01e-06	55.8	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	lapA	-	-	ko:K12549,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Cadherin_3,Calx-beta,DUF4347,HemolysinCabind,VWA,VWA_2
k141_1768_2	1120963.KB894495_gene3159	2.17e-16	75.9	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,2Q2U6@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	COG1862 Preprotein translocase subunit YajC	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
k141_1768_3	713586.KB900536_gene425	3.94e-44	154.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
k141_37_1	1111728.ATYS01000057_gene1315	1.72e-10	66.6	COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,1RR0U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
k141_475_1	391625.PPSIR1_28826	1.8e-93	297.0	COG1572@1|root,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria,2YWVC@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_38_2	1123368.AUIS01000011_gene1135	2.81e-29	110.0	COG2165@1|root,COG2165@2|Bacteria,1N7HN@1224|Proteobacteria,1SDMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II secretory pathway, pseudopilin PulG	mshA	-	-	ko:K10924	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
k141_1770_1	411460.RUMTOR_00339	2.2e-21	93.6	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3XZ6P@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
k141_1770_2	706587.Desti_0343	5.59e-32	119.0	COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,42PP1@68525|delta/epsilon subdivisions,2WM0A@28221|Deltaproteobacteria,2MQU3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	hoxU	-	1.6.5.3	ko:K05588	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_9,NADH-G_4Fe-4S_3
k141_616_1	857087.Metme_4088	6.1e-11	68.9	COG1639@1|root,COG1639@2|Bacteria,1NQVN@1224|Proteobacteria,1SKIE@1236|Gammaproteobacteria,1XGYW@135618|Methylococcales	135618|Methylococcales	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
k141_322_1	1120968.AUBX01000003_gene3408	4.77e-32	129.0	COG1361@1|root,COG2304@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,4PI2K@976|Bacteroidetes	976|Bacteroidetes	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
k141_1195_1	1439940.BAY1663_04776	2.18e-60	200.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iPC815.YPO3176,iSFV_1184.SFV_0386	polyprenyl_synt
k141_1923_1	713587.THITH_06140	7.94e-62	211.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales	135613|Chromatiales	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k141_1488_1	768671.ThimaDRAFT_4428	1.03e-48	166.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales	135613|Chromatiales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_617_1	953739.SVEN_0690	3.38e-58	192.0	COG0031@1|root,COG0031@2|Bacteria,2GNE4@201174|Actinobacteria	201174|Actinobacteria	E	cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
k141_1771_2	1449063.JMLS01000001_gene4418	2.12e-12	67.0	COG0745@1|root,COG0745@2|Bacteria,1VTZW@1239|Firmicutes,4HVB2@91061|Bacilli,26UYI@186822|Paenibacillaceae	91061|Bacilli	T	consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k141_177_1	566466.NOR53_2879	1.19e-40	152.0	COG1502@1|root,COG1502@2|Bacteria,1NVR8@1224|Proteobacteria	1224|Proteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
k141_906_1	1167006.UWK_01458	9.28e-52	176.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,2MPYE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_1196_1	998674.ATTE01000001_gene784	6.82e-81	265.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RQ4R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
k141_760_2	216596.RL2679	8.84e-95	291.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k141_41_1	522306.CAP2UW1_2625	1.05e-57	189.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
k141_1489_1	1121012.AUKX01000028_gene860	3.9e-22	99.4	COG2373@1|root,COG2931@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,4PKC4@976|Bacteroidetes	976|Bacteroidetes	J	this gene contains a nucleotide ambiguity which may be the result of a sequencing error	psrP1	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,SdrD_B,SprB
k141_1344_1	713586.KB900536_gene1465	1.91e-97	305.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
k141_761_1	2340.JV46_09630	1.04e-99	302.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
k141_1490_1	1502852.FG94_00126	5.44e-07	51.6	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,472IA@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
k141_179_1	1219375.CM002139_gene1329	2.9e-60	198.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1X3B7@135614|Xanthomonadales	135614|Xanthomonadales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
k141_325_1	794846.AJQU01000180_gene2209	8.26e-68	218.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,2UEEB@28211|Alphaproteobacteria,4BAW0@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	High confidence in function and specificity	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
k141_180_1	519989.ECTPHS_02199	1.04e-33	124.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
k141_1346_1	595460.RRSWK_04288	1.59e-124	372.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos
k141_326_1	1163617.SCD_n01883	1.06e-101	318.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,FlpD,Pyr_redox_2
k141_1776_1	395493.BegalDRAFT_2300	1.77e-82	274.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,45ZWV@72273|Thiotrichales	72273|Thiotrichales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k141_1634_1	1283300.ATXB01000001_gene1948	1.24e-39	150.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XE97@135618|Methylococcales	135618|Methylococcales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
k141_45_1	205922.Pfl01_4941	2.45e-66	207.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1YNKR@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	G	Belongs to the pseudouridine synthase RsuA family	rluE	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
k141_764_1	1178825.ALIH01000001_gene2272	1.79e-50	179.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,1HWZP@117743|Flavobacteriia	976|Bacteroidetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	POTRA,Patatin
k141_327_1	1323663.AROI01000066_gene4026	2.28e-39	132.0	2E4EA@1|root,32Z9I@2|Bacteria,1N7HE@1224|Proteobacteria,1SDU5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1777_1	1121939.L861_13400	3.13e-08	55.1	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
k141_1777_2	494416.AYXN01000015_gene288	7.58e-24	92.8	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,3NNVY@468|Moraxellaceae	1236|Gammaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
k141_1348_1	396588.Tgr7_2900	2.48e-35	138.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
k141_622_1	1042377.AFPJ01000004_gene393	9.27e-84	263.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,464KP@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k141_1055_1	1382304.JNIL01000001_gene3454	8.84e-38	130.0	COG1695@1|root,COG1695@2|Bacteria,1TTPP@1239|Firmicutes,4I3RZ@91061|Bacilli,27AJ9@186823|Alicyclobacillaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
k141_765_2	400682.PAC_15708167	1.37e-39	140.0	COG0235@1|root,KOG3699@2759|Eukaryota,38BZP@33154|Opisthokonta,3C15J@33208|Metazoa	33208|Metazoa	TZ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
k141_1494_1	10090.ENSMUSP00000080767	9.19e-08	55.5	COG0756@1|root,KOG3370@2759|Eukaryota,3A3T2@33154|Opisthokonta,3BIEA@33208|Metazoa,3D1WG@33213|Bilateria,48069@7711|Chordata,4973Z@7742|Vertebrata,3JDBR@40674|Mammalia,35P88@314146|Euarchontoglires,4PU4X@9989|Rodentia	33208|Metazoa	F	dUTPase	DUT	GO:0000166,GO:0000287,GO:0001889,GO:0003674,GO:0003824,GO:0004170,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010469,GO:0010646,GO:0010648,GO:0014070,GO:0015949,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0023051,GO:0023057,GO:0030545,GO:0030547,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032552,GO:0032556,GO:0034404,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0036094,GO:0042221,GO:0042975,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043497,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051259,GO:0051260,GO:0055086,GO:0061008,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0098772,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:2000272	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
k141_912_1	1111732.AZOD01000030_gene1361	1.36e-67	219.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1X3TZ@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
k141_183_1	985665.HPL003_07530	2.6e-52	186.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,26SZ3@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
k141_47_1	319003.Bra1253DRAFT_07227	3.22e-82	270.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,3JUXZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
k141_483_1	1121931.AUHG01000006_gene928	1.98e-07	50.4	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_913_1	395493.BegalDRAFT_0308	7.88e-76	239.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,4602W@72273|Thiotrichales	72273|Thiotrichales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
k141_1204_1	55601.VANGNB10_cI2305	1.09e-40	143.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,1S275@1236|Gammaproteobacteria,1XUZ7@135623|Vibrionales	135623|Vibrionales	V	COG1136 ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k141_1057_1	1265505.ATUG01000001_gene4210	2.08e-65	201.0	COG0662@1|root,COG0662@2|Bacteria,1N1T5@1224|Proteobacteria,42V1T@68525|delta/epsilon subdivisions,2WRU3@28221|Deltaproteobacteria,2MP7U@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
k141_48_1	1117314.PCIT_04932	1.06e-09	58.2	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,2Q0GE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
k141_48_2	575588.ACPN01000014_gene151	1e-77	258.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,3NJ1H@468|Moraxellaceae	1236|Gammaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k141_624_1	998674.ATTE01000001_gene2066	7.31e-29	113.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,TPR_12,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
k141_330_1	439235.Dalk_3679	2.06e-37	130.0	COG0640@1|root,COG0640@2|Bacteria,1N8M7@1224|Proteobacteria,42U4R@68525|delta/epsilon subdivisions,2WQ3N@28221|Deltaproteobacteria,2MKV5@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k141_1351_1	2340.JV46_14080	6.59e-58	184.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1TBIH@1236|Gammaproteobacteria,1JA1D@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
k141_1351_2	1144932.ATTF01000038_gene394	2.15e-11	63.9	COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,4BP96@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
k141_1205_1	1337936.IJ00_07170	5.97e-59	192.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1HIHK@1161|Nostocales	1117|Cyanobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
k141_1981_1	998674.ATTE01000001_gene2665	1.23e-47	154.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,460WX@72273|Thiotrichales	72273|Thiotrichales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
k141_1981_2	493475.GARC_3732	4.67e-06	47.4	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,4647Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009987,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019058,GO:0019068,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0044183,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0097159,GO:0097367,GO:0101031,GO:1901265,GO:1901363,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
k141_1251_1	1165096.ARWF01000001_gene154	4.31e-32	126.0	COG0642@1|root,COG4252@1|root,COG2205@2|Bacteria,COG4252@2|Bacteria,1MUHS@1224|Proteobacteria,2VIGN@28216|Betaproteobacteria,2KNMC@206350|Nitrosomonadales	206350|Nitrosomonadales	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c
k141_1602_1	1035839.AFNK01000079_gene56	2.28e-42	149.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1Y7FI@135625|Pasteurellales	135625|Pasteurellales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
k141_450_1	1297863.APJF01000009_gene239	1.39e-14	72.8	COG0582@1|root,COG0582@2|Bacteria,1R3TM@1224|Proteobacteria,2TS94@28211|Alphaproteobacteria,3JUDH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
k141_450_2	234267.Acid_1623	3.38e-28	111.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
k141_1894_1	338963.Pcar_0393	1.15e-28	109.0	COG4967@1|root,COG4967@2|Bacteria,1RKKA@1224|Proteobacteria,42Y2V@68525|delta/epsilon subdivisions,2WTFM@28221|Deltaproteobacteria,43V82@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Pfam:N_methyl_2	-	-	-	ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
k141_1026_1	583345.Mmol_0783	1.02e-49	180.0	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG5184@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG5184@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNPI@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VWA_2
k141_301_1	157783.LK03_20590	1.05e-80	248.0	COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,1RRI5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	belongs to the bacterial solute-binding protein 3 family	glnH	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K02030,ko:K10036	ko02010,map02010	M00227,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.2	-	-	SBP_bac_3
k141_1170_1	1487953.JMKF01000074_gene3686	8.8e-05	50.4	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
k141_14_2	1232428.CAVO010000014_gene750	0.000182	48.5	COG1629@1|root,COG4771@2|Bacteria,1TQBP@1239|Firmicutes,4H2P2@909932|Negativicutes	909932|Negativicutes	P	TonB-dependent receptor	cirA	-	-	ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
k141_451_1	1506583.JQJY01000019_gene3770	3.64e-20	81.6	2DPXX@1|root,333V7@2|Bacteria,4NX9I@976|Bacteroidetes,1I6GN@117743|Flavobacteriia,2NX39@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_591_1	1150469.RSPPHO_00872	8.58e-53	170.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2JPX2@204441|Rhodospirillales	204441|Rhodospirillales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
k141_1317_1	981384.AEYW01000028_gene4226	7.71e-66	214.0	COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria,4NCYX@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
k141_302_1	1144319.PMI16_02189	1.09e-14	75.9	COG3203@1|root,COG3203@2|Bacteria,1R6T4@1224|Proteobacteria,2VNSZ@28216|Betaproteobacteria,472C8@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
k141_1465_1	672.VV93_v1c36390	3.78e-14	72.8	COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,1XX4A@135623|Vibrionales	135623|Vibrionales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrome_CBB3
k141_737_1	338963.Pcar_0496	1.18e-41	152.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,42R9V@68525|delta/epsilon subdivisions,2WN4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
k141_1752_1	1348657.M622_08925	7.12e-23	96.7	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2VKC4@28216|Betaproteobacteria,2KV6P@206389|Rhodocyclales	206389|Rhodocyclales	N	Flagellar motor protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
k141_1605_1	1282876.BAOK01000002_gene894	1.19e-41	154.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_1605_2	1033802.SSPSH_003719	2.05e-20	92.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k141_1319_2	1177181.T9A_00890	8.76e-07	52.0	2BWJV@1|root,32U7J@2|Bacteria,1N47S@1224|Proteobacteria,1S8XJ@1236|Gammaproteobacteria,1XRRU@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_453_1	1230476.C207_02573	5.91e-09	60.5	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,3JV0U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	LysR family	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
k141_593_1	670487.Ocepr_0634	7.8e-118	360.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
k141_1174_1	1317118.ATO8_20449	1.9e-56	180.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_454_1	1049564.TevJSym_aw00170	2.33e-54	173.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the DsrF TusC family	tusC	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
k141_454_2	765910.MARPU_10895	2.21e-28	105.0	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales	135613|Chromatiales	P	sulfur relay protein TusB DsrH	-	-	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
k141_160_1	10658.DPOL_BPPRD	3.9e-08	61.6	4QAWD@10239|Viruses,4QVNG@35237|dsDNA viruses  no RNA stage,4QHTW@10656|Tectiviridae	10656|Tectiviridae	L	DNA binding	-	GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	-
k141_1467_1	642227.HA49_09670	3.79e-70	221.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,4BV3J@82986|Tatumella	1236|Gammaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	potH	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11075	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	iAF1260.b0856,iBWG_1329.BWG_0709,iE2348C_1286.E2348C_0853,iECDH10B_1368.ECDH10B_0926,iECDH1ME8569_1439.ECDH1ME8569_0808,iEcDH1_1363.EcDH1_2786,iJO1366.b0856,iJR904.b0856,iY75_1357.Y75_RS04455	BPD_transp_1
k141_1607_1	443144.GM21_2712	2.19e-19	87.4	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,42TJM@68525|delta/epsilon subdivisions,2WQGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
k141_1607_2	1173021.ALWA01000003_gene3321	1.54e-13	70.9	COG0365@1|root,COG0365@2|Bacteria,1G112@1117|Cyanobacteria	1117|Cyanobacteria	I	AMP-binding enzyme	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
k141_2043_1	96561.Dole_1461	7.78e-109	332.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MINQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
k141_887_1	529818.AMSG_00580T0	1.25e-20	94.0	COG0040@1|root,COG0107@1|root,COG0139@1|root,COG0141@1|root,KOG0623@2759|Eukaryota,KOG2697@2759|Eukaryota,KOG2831@2759|Eukaryota,KOG4311@2759|Eukaryota	2759|Eukaryota	E	phosphoribosyl-ATP diphosphatase activity	HIS1	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0004399,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016462,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.4.2.17,3.5.4.19,3.6.1.31	ko:K00765,ko:K01663,ko:K08736,ko:K11755,ko:K14152	ko00340,ko01100,ko01110,ko01230,ko01524,ko03430,ko05200,ko05210,map00340,map01100,map01110,map01230,map01524,map03430,map05200,map05210	M00026	R01071,R01158,R01163,R03012,R04035,R04037,R04558	RC00002,RC00010,RC00099,RC00242,RC00463,RC01055,RC01190,RC01943,RC02819,RC03200	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	GATase,HisG,HisG_C,His_biosynth,Histidinol_dh,PRA-CH,PRA-PH
k141_887_2	156889.Mmc1_3156	3.28e-22	92.8	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
k141_595_1	7213.XP_004528068.1	2.51e-69	234.0	COG0539@1|root,KOG1070@2759|Eukaryota,39N76@33154|Opisthokonta,3CPSG@33208|Metazoa,3DE11@33213|Bilateria,422RV@6656|Arthropoda,3SQVP@50557|Insecta	33208|Metazoa	A	S1 RNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	S1
k141_1031_1	1396141.BATP01000035_gene4106	4.42e-72	241.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12,WD40
k141_1899_1	545276.KB898727_gene453	2.4e-70	236.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k141_740_1	1167006.UWK_02016	9.75e-67	215.0	COG1413@1|root,COG1413@2|Bacteria,1P6NU@1224|Proteobacteria,4332R@68525|delta/epsilon subdivisions,2WXCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1468_1	1200557.JHWV01000002_gene111	2.22e-42	157.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4H25A@909932|Negativicutes	909932|Negativicutes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k141_1756_1	269482.Bcep1808_5809	1.45e-18	89.7	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2VJUV@28216|Betaproteobacteria,1KGU8@119060|Burkholderiaceae	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
k141_1469_1	1122951.ATUE01000007_gene813	3.18e-72	237.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KL	helicase	yoaA	GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
k141_305_1	1122603.ATVI01000006_gene548	3.53e-45	159.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1S6X1@1236|Gammaproteobacteria,1X450@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
k141_1177_1	926550.CLDAP_16150	9.31e-35	132.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD,DUF3179
k141_1901_1	1121013.P873_11010	1.22e-33	132.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Prolyl oligopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
k141_1609_1	159749.E7BWP2	4.07e-33	115.0	COG0254@1|root,2S1BJ@2759|Eukaryota	2759|Eukaryota	J	rRNA binding	rpl31	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k141_1609_2	13035.Dacsa_3680	2.02e-34	122.0	COG0103@1|root,COG0103@2|Bacteria,1G5NH@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
k141_2046_1	1128398.Curi_c18880	9.41e-12	70.5	COG1361@1|root,COG1361@2|Bacteria,1UQ5B@1239|Firmicutes,24AUI@186801|Clostridia,26AGX@186813|unclassified Clostridiales	186801|Clostridia	M	SdrD B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF3794,SdrD_B
k141_742_1	1510531.JQJJ01000011_gene2721	1.75e-44	155.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,3JR0C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
k141_1470_1	1122212.AULO01000006_gene1687	8.26e-07	52.0	COG1705@1|root,COG3951@1|root,COG1705@2|Bacteria,COG3951@2|Bacteria,1MX2W@1224|Proteobacteria,1RPGY@1236|Gammaproteobacteria,1XI0F@135619|Oceanospirillales	135619|Oceanospirillales	MNOU	Rod binding protein	flgJ	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Rod-binding
k141_1470_2	1266914.ATUK01000016_gene407	4.61e-33	125.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1WVV3@135613|Chromatiales	135613|Chromatiales	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
k141_306_1	2325.TKV_c05910	5.38e-62	206.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,42EXF@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
k141_1758_1	391626.OAN307_c47530	1.07e-53	187.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	kefC1	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
k141_890_1	28072.Nos7524_0122	2.8e-07	57.4	COG4974@1|root,COG4974@2|Bacteria,1G0ZU@1117|Cyanobacteria,1HPNN@1161|Nostocales	1117|Cyanobacteria	L	PFAM Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k141_21_1	279714.FuraDRAFT_3869	6.99e-79	262.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KQ2X@206351|Neisseriales	206351|Neisseriales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
k141_163_1	118161.KB235922_gene4653	4.93e-69	218.0	COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,3VHYQ@52604|Pleurocapsales	1117|Cyanobacteria	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
k141_163_2	102125.Xen7305DRAFT_00014800	7.38e-21	89.7	COG1028@1|root,COG1028@2|Bacteria,1G4CM@1117|Cyanobacteria,3VMT8@52604|Pleurocapsales	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_1036_1	1122176.KB903540_gene77	3.7e-31	126.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	CHU_C,PKD,SprB
k141_164_1	748658.KB907312_gene1886	2.17e-32	121.0	COG1028@1|root,COG1028@2|Bacteria,1RFQT@1224|Proteobacteria,1S58Z@1236|Gammaproteobacteria,1X0HD@135613|Chromatiales	135613|Chromatiales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_164_2	177437.HRM2_34120	1.55e-44	150.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42UNS@68525|delta/epsilon subdivisions,2WQ4W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
k141_1037_1	525909.Afer_0106	6.92e-50	171.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
k141_460_1	754476.Q7A_3024	3.24e-11	64.3	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,463VW@72273|Thiotrichales	72273|Thiotrichales	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
k141_398_2	1304885.AUEY01000002_gene433	6.6e-08	53.1	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHUJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Periplasmic sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,Response_reg
k141_846_1	290317.Cpha266_1782	2.45e-62	215.0	COG0209@1|root,COG0209@2|Bacteria,1FD9Z@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC
k141_399_1	1210884.HG799471_gene14655	1.9e-45	166.0	COG2834@1|root,COG3209@1|root,COG2834@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF4082,DUF4347,HemolysinCabind,SprB
k141_2009_1	748671.LCRIS_01651	1.38e-10	58.9	2DMNG@1|root,32SP1@2|Bacteria,1VAXC@1239|Firmicutes,4HM1Q@91061|Bacilli,3F8QG@33958|Lactobacillaceae	91061|Bacilli	S	COG NOG14552 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1856_1	685727.REQ_24360	1.69e-45	164.0	COG2225@1|root,COG2225@2|Bacteria,2HHAG@201174|Actinobacteria,4FWJY@85025|Nocardiaceae	201174|Actinobacteria	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
k141_1426_1	1121396.KB892901_gene2222	3.97e-111	327.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42M9R@68525|delta/epsilon subdivisions,2WKQM@28221|Deltaproteobacteria,2MIEY@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
k141_848_1	383372.Rcas_1337	1.99e-12	69.7	COG2421@1|root,COG2421@2|Bacteria,2G63Y@200795|Chloroflexi,376X6@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Acetamidase Formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
k141_400_2	765913.ThidrDRAFT_1840	1.13e-115	341.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RQDY@1236|Gammaproteobacteria,1WXVM@135613|Chromatiales	135613|Chromatiales	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k141_850_1	379066.GAU_0148	1.92e-83	259.0	COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
k141_1428_1	880073.Calab_2785	2.57e-53	184.0	COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria	2|Bacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
k141_1134_1	715451.ambt_20910	4.68e-39	148.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D1@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k141_1281_2	997346.HMPREF9374_2134	5.06e-08	57.4	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4HBER@91061|Bacilli,27BB1@186824|Thermoactinomycetaceae	91061|Bacilli	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k141_2012_1	1121403.AUCV01000001_gene742	5.37e-78	245.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
k141_1859_1	7029.ACYPI067482-PA	2.81e-05	53.9	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria	2759|Eukaryota	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k141_1429_1	709032.Sulku_1049	3.68e-34	135.0	COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
k141_1574_1	717231.Flexsi_0440	1.41e-50	172.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_561_1	1304875.JAFZ01000002_gene1	1.91e-27	102.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_703_1	765912.Thimo_1749	2.64e-61	199.0	28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria,1WX53@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_852_1	983920.Y88_0801	6.23e-41	147.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2K0JS@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
k141_852_2	349521.HCH_05975	6.95e-13	63.9	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1XM5V@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
k141_1282_1	583355.Caka_1697	7.65e-69	218.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
k141_1136_1	1033734.CAET01000065_gene2231	2.22e-89	276.0	COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,4HEYP@91061|Bacilli,1ZM4F@1386|Bacillus	91061|Bacilli	E	Beta-eliminating lyase	-	-	-	-	-	-	-	-	-	-	-	-	Beta_elim_lyase
k141_1283_1	1196095.GAPWK_0557	3.96e-17	79.7	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	abc transporter atp-binding protein	yjjK	GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
k141_405_1	1208323.B30_07201	2.97e-27	114.0	COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	ATP-binding protein'	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k141_1138_1	572477.Alvin_0759	6.64e-21	97.1	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales	135613|Chromatiales	M	PFAM Lytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
k141_130_1	765912.Thimo_2511	9.85e-77	236.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1WXP4@135613|Chromatiales	135613|Chromatiales	P	ABC transporter	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
k141_1577_2	187272.Mlg_2079	2.71e-51	178.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
k141_1863_1	319224.Sputcn32_3591	4.89e-28	117.0	COG2911@1|root,COG2931@1|root,COG3209@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2Q9AA@267890|Shewanellaceae	1236|Gammaproteobacteria	Q	Outer membrane adhesin like proteiin	rtxA	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,VWA,VWA_2
k141_267_2	1121403.AUCV01000013_gene3914	1.16e-08	58.2	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
k141_1285_1	404589.Anae109_0762	1.77e-94	299.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
k141_1433_1	215803.DB30_7957	5.09e-12	71.2	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10,Peptidase_M57
k141_131_1	519989.ECTPHS_01134	5.7e-87	279.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
k141_1864_1	1229205.BUPH_08235	8.12e-17	82.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria,1K341@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_1140_1	384676.PSEEN5270	7.74e-51	176.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
k141_1434_1	991.IW20_03685	2.38e-25	104.0	COG1740@1|root,COG1740@2|Bacteria,4NK1F@976|Bacteroidetes,1I5EP@117743|Flavobacteriia,2NYDC@237|Flavobacterium	976|Bacteroidetes	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
k141_1434_2	1304888.ATWF01000001_gene2430	1.45e-32	124.0	COG0374@1|root,COG0374@2|Bacteria,2GEUV@200930|Deferribacteres	200930|Deferribacteres	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
k141_1578_1	686340.Metal_1983	5.99e-38	134.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RRT6@1236|Gammaproteobacteria,1XFBD@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
k141_1578_2	1116472.MGMO_26c00030	1.44e-09	57.4	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	-	-	-	ko:K03615,ko:K03969,ko:K09749,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,PspA_IM30
k141_707_1	2340.JV46_15320	1.15e-174	498.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	pyridine nucleotide-disulphide oxidoreductase	sqr	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
k141_1720_2	1121405.dsmv_1807	5.96e-69	222.0	2DPHU@1|root,3324S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_132_1	977880.RALTA_B1917	2.91e-60	198.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2VHTU@28216|Betaproteobacteria,1KC32@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF808)	yedI	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
k141_269_1	913865.DOT_1769	7.06e-28	116.0	COG4974@1|root,COG4974@2|Bacteria,1U0MD@1239|Firmicutes,24FWH@186801|Clostridia,261AT@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
k141_1865_1	349521.HCH_01772	2.42e-19	80.9	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1XKJQ@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
k141_1865_2	870187.Thini_3414	5.28e-39	142.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,46021@72273|Thiotrichales	72273|Thiotrichales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
k141_1141_1	870187.Thini_3384	9.36e-42	152.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,4608M@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
k141_2018_1	1026882.MAMP_02024	5.01e-41	140.0	2E4SV@1|root,32ZM7@2|Bacteria,1N8VN@1224|Proteobacteria,1S6AW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative transmembrane protein (PGPGW)	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
k141_1579_1	28444.JODQ01000007_gene5240	1.83e-05	52.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Big_3,CBM60,CHU_C,CUB,Gram_pos_anchor,LRR_5,Laminin_G_3,SprB
k141_1721_1	1437448.AZRT01000025_gene2686	1.96e-09	62.8	COG2503@1|root,COG2503@2|Bacteria,1RB4N@1224|Proteobacteria,2U5IB@28211|Alphaproteobacteria,1J3SJ@118882|Brucellaceae	28211|Alphaproteobacteria	S	HAD superfamily, subfamily IIIB (Acid phosphatase)	-	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
k141_133_1	1304275.C41B8_07402	5.52e-27	111.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
k141_1288_1	1366046.HIMB11_02415	8.73e-87	267.0	COG0683@1|root,COG0683@2|Bacteria,1PF5W@1224|Proteobacteria,2V88D@28211|Alphaproteobacteria,3ZIK4@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1142_1	1307759.JOMJ01000003_gene191	1.53e-20	95.5	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2M829@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
k141_708_1	519989.ECTPHS_13208	5.32e-22	89.7	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
k141_708_2	28229.ND2E_1696	3.33e-74	223.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,2Q6PP@267889|Colwelliaceae	1236|Gammaproteobacteria	J	Ribosomal protein S12/S23	rpsL	GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
k141_709_1	1121920.AUAU01000009_gene1934	7.07e-15	79.7	COG0515@1|root,COG0515@2|Bacteria,3Y3NW@57723|Acidobacteria	57723|Acidobacteria	T	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
k141_134_1	765914.ThisiDRAFT_1907	4.84e-95	288.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
k141_272_1	1415778.JQMM01000001_gene1715	2.52e-22	97.1	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1J6DG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
k141_1736_1	331869.BAL199_03474	1.89e-12	68.2	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2VF6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
k141_1736_2	1026882.MAMP_01338	1.48e-12	69.3	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,45ZVX@72273|Thiotrichales	72273|Thiotrichales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
k141_435_1	83406.HDN1F_36460	1.25e-74	244.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tktA	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990	Transket_pyr,Transketolase_C,Transketolase_N
k141_290_1	89187.ISM_05325	3.77e-29	113.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,46PC7@74030|Roseovarius	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain	bztA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
k141_2024_1	1177181.T9A_02162	3.29e-20	90.9	COG4773@1|root,COG4773@2|Bacteria,1R0QY@1224|Proteobacteria,1T4P1@1236|Gammaproteobacteria,1XMZY@135619|Oceanospirillales	135619|Oceanospirillales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
k141_2024_2	391008.Smal_0985	2.84e-20	93.6	COG5266@1|root,COG5266@2|Bacteria,1MXQS@1224|Proteobacteria,1RREM@1236|Gammaproteobacteria,1X45X@135614|Xanthomonadales	135614|Xanthomonadales	P	abc transporter, permease	-	-	-	-	-	-	-	-	-	-	-	-	DUF4198
k141_1594_1	631362.Thi970DRAFT_02366	2.58e-45	163.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria,1WXGD@135613|Chromatiales	135613|Chromatiales	L	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
k141_1016_1	935840.JAEQ01000022_gene4295	9.23e-06	53.5	COG1361@1|root,COG3291@1|root,COG4719@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,COG4719@2|Bacteria,1R5G4@1224|Proteobacteria,2UC86@28211|Alphaproteobacteria,43MTR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k141_1306_1	1340493.JNIF01000003_gene1588	3.32e-17	83.6	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_28,HTH_29,HTH_32
k141_2019_1	1266909.AUAG01000063_gene1806	1.84e-159	461.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales	135613|Chromatiales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
k141_137_1	1249627.D779_3724	4.03e-21	93.2	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
k141_1147_1	1317122.ATO12_10950	8.11e-35	136.0	COG3391@1|root,COG4886@1|root,COG5184@1|root,COG3391@2|Bacteria,COG4886@2|Bacteria,COG5184@2|Bacteria,4PKDT@976|Bacteroidetes,1IJ8G@117743|Flavobacteriia,2YIJK@290174|Aquimarina	976|Bacteroidetes	DZ	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HYR
k141_572_1	1121937.AUHJ01000012_gene2740	7.58e-38	133.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,464RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
k141_1725_1	207954.MED92_16240	1.2e-61	197.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales	135619|Oceanospirillales	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_1585_1	877411.JMMA01000002_gene2636	1.2e-10	65.5	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,3WHXU@541000|Ruminococcaceae	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
k141_1585_2	521719.ATXQ01000007_gene1180	5.2e-28	111.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1YEV8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
k141_713_1	504487.JCM19302_4144	3.4e-06	50.4	2DBTS@1|root,2ZB0P@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
k141_1871_1	561231.Pecwa_3444	1.38e-91	291.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1MQ88@122277|Pectobacterium	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
k141_415_1	1392488.JHZY01000004_gene3205	2.83e-48	176.0	COG2304@1|root,COG2373@1|root,COG3209@1|root,COG3210@1|root,COG3291@1|root,COG4932@1|root,COG5384@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,COG5384@2|Bacteria,4NDZC@976|Bacteroidetes,1IK1E@117743|Flavobacteriia	976|Bacteroidetes	M	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
k141_573_1	1167006.UWK_02387	3.7e-37	138.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
k141_1726_1	998674.ATTE01000001_gene1498	2.26e-14	73.2	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,45ZMR@72273|Thiotrichales	72273|Thiotrichales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k141_2021_1	177437.HRM2_02370	5.26e-66	226.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJN5@28221|Deltaproteobacteria,2MIEI@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_714_1	398579.Spea_0423	8.93e-21	96.3	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,2QB92@267890|Shewanellaceae	1236|Gammaproteobacteria	M	surface antigen variable number repeat protein	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
k141_1004_1	1279017.AQYJ01000026_gene304	1.03e-43	161.0	2ECB1@1|root,3369C@2|Bacteria,1NX58@1224|Proteobacteria,1SRD4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1442_1	1049564.TevJSym_ae00700	3.72e-08	60.1	COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J7PV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL,cNMP_binding
k141_1150_1	1049564.TevJSym_ai00540	1.72e-33	124.0	arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k141_1150_2	1123355.JHYO01000007_gene393	2.74e-32	118.0	arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,2TWWI@28211|Alphaproteobacteria,370DB@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1538)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
k141_1727_1	109760.SPPG_07999T0	2.29e-20	92.4	COG0722@1|root,2QPSU@2759|Eukaryota,38CAA@33154|Opisthokonta,3NVDJ@4751|Fungi	4751|Fungi	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	ARO4	GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
k141_417_1	159749.K0S4J3	3.39e-53	171.0	2CNI2@1|root,2QWGG@2759|Eukaryota,2XE1A@2836|Bacillariophyta	2836|Bacillariophyta	C	Seems to be required for the assembly of the photosystem I complex	ycf4	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Ycf4
k141_417_2	2880.D1J7D5	4.85e-12	60.5	2CHYC@1|root,2S3QA@2759|Eukaryota	2759|Eukaryota	C	photosynthetic electron transport chain	psbE	-	-	ko:K02707,ko:K02713	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	Cytochrom_B559,Cytochrom_B559a,PsbL
k141_2023_1	545243.BAEV01000060_gene285	6.3e-18	85.1	COG2206@1|root,COG2206@2|Bacteria,1V1J0@1239|Firmicutes,24FUR@186801|Clostridia,36FET@31979|Clostridiaceae	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
k141_1587_1	247639.MGP2080_01861	3.02e-74	244.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1J4FA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_1005_1	1449338.JQLU01000005_gene2277	8.13e-49	170.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,27FNK@186828|Carnobacteriaceae	91061|Bacilli	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k141_418_1	1229909.NSED_01890	2.76e-111	333.0	COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
k141_1728_1	698440.XP_007290556.1	6.69e-19	89.0	COG0133@1|root,COG0159@1|root,KOG1395@2759|Eukaryota,KOG4175@2759|Eukaryota,38GS5@33154|Opisthokonta,3NUJ5@4751|Fungi,3QJDI@4890|Ascomycota,20VG0@147548|Leotiomycetes	4751|Fungi	E	Tryptophan synthase alpha chain	-	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01694	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R02722	RC00210,RC00700,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Trp_syntA
k141_1728_2	2880.D8LLB1	5.47e-34	132.0	COG0133@1|root,COG0159@1|root,KOG1395@2759|Eukaryota,KOG4175@2759|Eukaryota	2759|Eukaryota	E	tryptophan synthase activity	TRP5	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009606,GO:0009607,GO:0009617,GO:0009628,GO:0009629,GO:0009630,GO:0009651,GO:0009683,GO:0009684,GO:0009719,GO:0009725,GO:0009735,GO:0009850,GO:0009851,GO:0009941,GO:0009987,GO:0010033,GO:0010817,GO:0016020,GO:0016043,GO:0016053,GO:0016829,GO:0016830,GO:0016832,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0019904,GO:0031967,GO:0031975,GO:0032787,GO:0033036,GO:0033037,GO:0033554,GO:0033984,GO:0034641,GO:0034754,GO:0042221,GO:0042401,GO:0042430,GO:0042435,GO:0042445,GO:0042446,GO:0042545,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045229,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051179,GO:0051641,GO:0051704,GO:0051707,GO:0051716,GO:0052386,GO:0052482,GO:0052542,GO:0052543,GO:0052544,GO:0052545,GO:0065007,GO:0065008,GO:0070727,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0098542,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.2.8,4.2.1.20	ko:K01694,ko:K01695,ko:K01696,ko:K10882,ko:K13222	ko00260,ko00400,ko00402,ko01100,ko01110,ko01130,ko01230,ko03440,ko03460,map00260,map00400,map00402,map01100,map01110,map01130,map01230,map03440,map03460	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	PALP,Trp_syntA
k141_1295_1	1158292.JPOE01000005_gene1001	1.36e-64	208.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
k141_1875_1	391615.ABSJ01000039_gene1859	1.64e-09	62.8	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1J4V7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
k141_143_1	1254432.SCE1572_35470	4.31e-22	98.2	COG2844@1|root,COG2844@2|Bacteria,1P77X@1224|Proteobacteria,433GP@68525|delta/epsilon subdivisions,2WXFN@28221|Deltaproteobacteria,2YW9R@29|Myxococcales	28221|Deltaproteobacteria	O	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD
k141_281_1	868864.Dester_1479	2.66e-17	85.1	28HPH@1|root,2Z7XH@2|Bacteria,2G4EG@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1590_1	1479239.JQMU01000001_gene307	2.47e-24	95.9	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,2K589@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
k141_1008_1	400668.Mmwyl1_2575	3.32e-67	211.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1XHWD@135619|Oceanospirillales	135619|Oceanospirillales	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
k141_1154_2	1347369.CCAD010000010_gene2365	4.73e-07	51.2	2BTFW@1|root,32NN5@2|Bacteria,1UB53@1239|Firmicutes,4IMHN@91061|Bacilli,1ZK6C@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1446_2	511062.GU3_05630	4.54e-21	88.6	COG2010@1|root,COG2010@2|Bacteria,1N5P8@1224|Proteobacteria,1S9K3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
k141_1877_1	572544.Ilyop_0916	8.93e-16	77.4	COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria	32066|Fusobacteria	C	PFAM Iron-containing alcohol dehydrogenase	fucO	-	1.1.1.77	ko:K00048	ko00630,ko00640,ko01120,map00630,map00640,map01120	-	R01781,R02257	RC00087,RC00099	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
k141_1877_2	1121403.AUCV01000033_gene3647	5.94e-15	77.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42NP2@68525|delta/epsilon subdivisions,2WIY2@28221|Deltaproteobacteria,2MJUV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
k141_1010_1	570967.JMLV01000002_gene1855	7.29e-63	216.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2JQQN@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
k141_1298_1	1366046.HIMB11_02076	2.22e-66	218.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2V7V8@28211|Alphaproteobacteria,3ZI7Y@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	P	Domain of unknown function (DUF4976)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
k141_579_2	1449076.JOOE01000002_gene1178	1.76e-75	229.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,2K40G@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
k141_721_1	1203606.HMPREF1526_02587	1.48e-22	92.8	2DPDN@1|root,331NP@2|Bacteria,1VFF8@1239|Firmicutes,24S9D@186801|Clostridia,36VF0@31979|Clostridiaceae	186801|Clostridia	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_284_2	7029.ACYPI55449-PA	6.04e-12	74.3	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,41XP3@6656|Arthropoda,3SQBU@50557|Insecta	2759|Eukaryota	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k141_1299_1	1123518.ARWI01000001_gene1483	7.43e-05	41.2	2EG09@1|root,339SB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1011_1	1120970.AUBZ01000082_gene2711	2.49e-21	83.6	2EK6X@1|root,33DXA@2|Bacteria,1NGFC@1224|Proteobacteria,1SH5J@1236|Gammaproteobacteria,468YD@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1012_1	675816.VIA_001939	4.5e-68	212.0	COG3806@1|root,COG3806@2|Bacteria,1R52I@1224|Proteobacteria,1RNI5@1236|Gammaproteobacteria,1XVGP@135623|Vibrionales	135623|Vibrionales	T	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
k141_1012_2	1034943.BN1094_00270	3.79e-13	68.6	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1JC4U@118969|Legionellales	118969|Legionellales	S	ATPase family associated with various cellular activities (AAA)	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
k141_868_1	870187.Thini_0476	1.36e-60	192.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,460DN@72273|Thiotrichales	72273|Thiotrichales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
k141_308_1	1116472.MGMO_45c00340	3.39e-75	238.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
k141_1474_1	7217.FBpp0121929	2.52e-12	71.2	COG3665@1|root,2QSJ0@2759|Eukaryota,38FKH@33154|Opisthokonta,3BPQC@33208|Metazoa,3D712@33213|Bilateria,42268@6656|Arthropoda,3SJ17@50557|Insecta,44YWR@7147|Diptera,45NGS@7214|Drosophilidae	33208|Metazoa	S	Domain of unknown function (DUF1989)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1989
k141_1038_1	1121939.L861_17620	1.39e-15	81.6	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XNVR@135619|Oceanospirillales	135619|Oceanospirillales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT
k141_461_1	1123518.ARWI01000001_gene1639	1.75e-18	90.1	COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_3
k141_165_1	1469245.JFBG01000012_gene893	1.55e-58	198.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,1SJKY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
k141_165_2	1337093.MBE-LCI_2326	7.4e-21	93.2	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TUTB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	dmgdh5	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
k141_1328_1	1121405.dsmv_2068	3.38e-22	100.0	COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions,2X6WX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_310_1	96561.Dole_3250	3.32e-89	275.0	COG3039@1|root,COG3039@2|Bacteria,1QQ9Q@1224|Proteobacteria,42S7X@68525|delta/epsilon subdivisions,2WNJ2@28221|Deltaproteobacteria,2MJG4@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
k141_1475_1	1485545.JQLW01000008_gene2072	4.99e-08	56.6	COG2836@1|root,COG2836@2|Bacteria	2|Bacteria	K	Biogenesis protein	braZ	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2,Ferric_reduct
k141_1475_2	1121352.JHZP01000001_gene631	7.31e-19	86.3	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,2KQ5X@206351|Neisseriales	206351|Neisseriales	K	Cyclic nucleotide-binding domain protein	anr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
k141_1907_1	519989.ECTPHS_01374	8.71e-67	217.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
k141_1907_2	1042375.AFPL01000031_gene806	6.73e-16	76.3	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,46416@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
k141_1183_1	675814.VIC_002177	9.03e-10	62.8	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XV3Y@135623|Vibrionales	135623|Vibrionales	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,PAS_8,PAS_9
k141_1183_2	671143.DAMO_1717	3.95e-29	117.0	COG0840@1|root,COG0840@2|Bacteria,2NQS9@2323|unclassified Bacteria	2|Bacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,TarH,dCache_1
k141_311_1	396588.Tgr7_0726	1.3e-48	168.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
k141_167_1	1121877.JQKF01000035_gene1966	1.95e-19	84.3	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CN2D@84992|Acidimicrobiia	84992|Acidimicrobiia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
k141_167_2	573.JG24_20095	6.73e-05	47.4	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	IspD
k141_895_1	1150864.MILUP08_44104	1.43e-09	65.1	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,2GMCT@201174|Actinobacteria,4DFAS@85008|Micromonosporales	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
k141_1761_2	1094489.BAnh1_09420	3.86e-25	103.0	COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2U7X4@28211|Alphaproteobacteria,48TF4@772|Bartonellaceae	28211|Alphaproteobacteria	G	Phage lysozyme	-	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	Phage_lysozyme
k141_606_1	713587.THITH_09460	1.26e-71	235.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
k141_464_1	349521.HCH_02190	1.01e-71	233.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales	135619|Oceanospirillales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
k141_1617_1	870187.Thini_3031	1.15e-05	47.4	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,460AE@72273|Thiotrichales	72273|Thiotrichales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
k141_1617_2	948565.AFFP02000027_gene179	3.27e-43	150.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1Y6Y1@135625|Pasteurellales	135625|Pasteurellales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
k141_312_1	70448.A0A090M691	5.55e-44	160.0	COG0276@1|root,KOG1321@2759|Eukaryota,37KW0@33090|Viridiplantae,34HCN@3041|Chlorophyta	3041|Chlorophyta	H	Catalyzes the ferrous insertion into protoporphyrin IX	HEMH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
k141_1185_1	1335757.SPICUR_08235	4.39e-71	215.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1WY84@135613|Chromatiales	135613|Chromatiales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
k141_1185_2	1121940.AUDZ01000015_gene1430	1.78e-17	75.5	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1XKR2@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
k141_607_1	90814.KL370892_gene2208	6.69e-08	49.3	2EG09@1|root,339SB@2|Bacteria,1NJCW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_607_2	1166130.H650_16415	8.98e-14	64.3	2EG3W@1|root,339VW@2|Bacteria,1NHIR@1224|Proteobacteria,1SGXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1910_1	96561.Dole_3031	4.29e-60	196.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2MJFR@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
k141_29_1	1085623.GNIT_1459	2.63e-58	203.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,463YW@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
k141_465_1	247639.MGP2080_05075	1.83e-102	318.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1J8XH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3119 Arylsulfatase A and related enzymes	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
k141_1479_1	1123367.C666_08995	7.37e-24	100.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KUHY@206389|Rhodocyclales	206389|Rhodocyclales	T	COG0631 Serine threonine protein phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
k141_1479_2	1122165.AUHS01000012_gene2875	1.97e-11	63.2	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1JC6G@118969|Legionellales	118969|Legionellales	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
k141_608_1	754477.Q7C_2337	1.58e-55	191.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,4620R@72273|Thiotrichales	72273|Thiotrichales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
k141_750_1	1033802.SSPSH_000244	3.23e-106	331.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
k141_1619_1	1280946.HY29_17320	6.5e-19	87.0	COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,2U4UN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K03451	-	-	-	-	ko00000	2.A.15	-	-	BCCT
k141_1763_1	1192034.CAP_4068	2.87e-60	201.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
k141_466_1	1298865.H978DRAFT_2940	8.88e-51	162.0	COG3093@1|root,COG3093@2|Bacteria,1RJAH@1224|Proteobacteria,1S6Y4@1236|Gammaproteobacteria,467C8@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG3093 Plasmid maintenance system antidote protein	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
k141_466_2	314278.NB231_13931	2.87e-21	85.1	COG3549@1|root,COG3549@2|Bacteria,1MZ4I@1224|Proteobacteria,1S9CP@1236|Gammaproteobacteria,1X12G@135613|Chromatiales	135613|Chromatiales	S	Plasmid maintenance system killer	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
k141_1334_1	247633.GP2143_00572	0.000471	48.5	COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
k141_609_1	1535422.ND16A_2986	6.09e-89	284.0	COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QWC6@1224|Proteobacteria,1RPDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hyfA	-	-	ko:K12136	-	-	-	-	ko00000,ko01000	-	-	iEcolC_1368.EcolC_1195,iUMNK88_1353.UMNK88_3076	Fer4,Fer4_3,Fer4_4,Fer4_6,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3,cNMP_binding
k141_315_1	693986.MOC_5191	1.05e-53	176.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,1JTBT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	NADP oxidoreductase coenzyme F420-dependent	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
k141_1481_1	247634.GPB2148_3624	9.02e-103	321.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
k141_1764_1	519989.ECTPHS_08271	5.01e-99	304.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
k141_752_1	1232410.KI421425_gene1546	7.44e-65	203.0	COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
k141_752_2	1232410.KI421425_gene1545	9.09e-19	81.6	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,43UYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
k141_2059_1	450851.PHZ_c1194	8e-38	145.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U6DG@28211|Alphaproteobacteria,2KITA@204458|Caulobacterales	204458|Caulobacterales	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
k141_1622_1	440250.A5HL37_9CAUD	2.04e-05	52.0	4QGZN@10239|Viruses,4R0FF@35237|dsDNA viruses  no RNA stage,4QTUK@28883|Caudovirales,4QNE5@10744|Podoviridae	10744|Podoviridae	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_33_1	352165.HMPREF7215_2348	1.96e-31	125.0	COG2986@1|root,COG2986@2|Bacteria,3TAK7@508458|Synergistetes	508458|Synergistetes	E	TIGRFAM histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
k141_900_1	159749.E7BWK4	1.36e-114	336.0	28IP8@1|root,2QR09@2759|Eukaryota,2XF0J@2836|Bacillariophyta	2836|Bacillariophyta	C	Photosynthetic reaction centre protein	psbA	-	1.10.3.9	ko:K02703	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Photo_RC
k141_1766_1	56780.SYN_03416	9.06e-12	59.7	2EMP1@1|root,33FBF@2|Bacteria,1NPTU@1224|Proteobacteria,432U4@68525|delta/epsilon subdivisions,2WXUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_318_1	631454.N177_1638	1.37e-67	219.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit	cobZ	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
k141_611_1	2340.JV46_14840	1.9e-32	125.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1J570@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k141_2202_1	748247.AZKH_1545	1.33e-38	147.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,DUF4347,DUF5122,HemolysinCabind,Lactonase,Laminin_G_3,Peptidase_M10_C,VWA_2,W_rich_C
k141_1190_2	717774.Marme_3317	5.08e-26	103.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria,1XJ82@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the UPF0502 family	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
k141_34_1	1089439.KB902271_gene1918	2.75e-25	103.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,4605U@72273|Thiotrichales	72273|Thiotrichales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k141_34_2	42565.FP66_07480	3.83e-45	159.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XIAH@135619|Oceanospirillales	135619|Oceanospirillales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
k141_34_3	515620.EUBELI_01813	1.59e-15	75.5	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,25VPX@186806|Eubacteriaceae	186801|Clostridia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
k141_1767_1	1535422.ND16A_1978	3.42e-29	119.0	COG1404@1|root,COG1404@2|Bacteria,1N6G1@1224|Proteobacteria,1RSME@1236|Gammaproteobacteria,2Q5UQ@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
k141_1767_2	929703.KE386491_gene483	1.38e-12	70.1	COG0642@1|root,COG3292@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47Y2E@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator three Y domain protein	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y
k141_1339_1	935557.ATYB01000009_gene1181	1.09e-07	58.5	COG3899@1|root,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
k141_319_1	105559.Nwat_0438	2.28e-108	323.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1WVWR@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
k141_902_1	582899.Hden_0691	1.45e-109	324.0	COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Pyr_redox_2
k141_1918_1	95619.PM1_0225840	4.16e-23	102.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RMQ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	HA62_01445	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
k141_612_1	558884.JRGM01000031_gene633	4.69e-15	78.6	COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1MVUT@1224|Proteobacteria,1RQB3@1236|Gammaproteobacteria,1Y3G5@135624|Aeromonadales	135624|Aeromonadales	E	T-protein	tyrA	-	1.3.1.12,5.4.99.5	ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R01715,R01728	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
k141_35_1	1089548.KI783301_gene3246	3.64e-12	68.2	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,4HA8W@91061|Bacilli,3WDW3@539002|Bacillales incertae sedis	91061|Bacilli	S	Methyltransferase small domain	yabB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.223	ko:K07461,ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,MTS
k141_35_2	439235.Dalk_5279	1.72e-13	70.1	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,2MHQI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
k141_756_1	765913.ThidrDRAFT_2160	5.32e-39	144.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
k141_473_1	243233.MCA0044	4.05e-34	118.0	2E3CN@1|root,32YBX@2|Bacteria,1N716@1224|Proteobacteria,1SEFN@1236|Gammaproteobacteria,1XGNQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1045_1	644966.Tmar_1241	1.93e-35	137.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WCNJ@538999|Clostridiales incertae sedis	186801|Clostridia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
k141_173_1	1144672.F966_00451	3.17e-66	220.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae	1236|Gammaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
k141_1340_1	247634.GPB2148_3752	2.27e-64	220.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1J4ZW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k141_1781_1	1168034.FH5T_20550	1.43e-86	268.0	COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia	976|Bacteroidetes	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
k141_916_1	1121405.dsmv_1402	9.92e-26	111.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,42QD3@68525|delta/epsilon subdivisions,2WKMQ@28221|Deltaproteobacteria,2MK2X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
k141_1353_1	159749.E7BWF9	4.5e-107	320.0	28ISP@1|root,2QR3X@2759|Eukaryota,2XE5P@2836|Bacillariophyta	2836|Bacillariophyta	P	One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation	-	-	-	ko:K02705	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	PSII
k141_1353_2	159749.K0RGG6	1.57e-10	60.1	2CNIT@1|root,2QWJF@2759|Eukaryota	2759|Eukaryota	C	photosynthetic electron transport in photosystem II	psbD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.10.3.9	ko:K02706	ko00195,ko01100,map00195,map01100	M00161	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	PSII,Photo_RC
k141_1640_1	522306.CAP2UW1_3683	4.35e-90	280.0	COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,2W66H@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_188_1	1167006.UWK_01505	3.46e-33	117.0	2ED51@1|root,3371S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_627_1	572477.Alvin_2992	6.47e-57	191.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1WXCF@135613|Chromatiales	135613|Chromatiales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
k141_1208_1	305700.B447_03923	1.01e-18	91.3	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,2KVIK@206389|Rhodocyclales	206389|Rhodocyclales	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
k141_771_1	2340.JV46_14410	7.25e-52	185.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
k141_1500_1	396588.Tgr7_2963	1.1e-18	84.7	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1WW8U@135613|Chromatiales	135613|Chromatiales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
k141_1354_1	399741.Spro_3694	1.61e-26	99.8	2CIMK@1|root,32S89@2|Bacteria,1N0NJ@1224|Proteobacteria,1S9BM@1236|Gammaproteobacteria,403U2@613|Serratia	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3302
k141_1354_2	425104.Ssed_3767	2.59e-34	132.0	COG0348@1|root,COG0369@1|root,COG4659@1|root,COG0348@2|Bacteria,COG0369@2|Bacteria,COG4659@2|Bacteria,1QUAH@1224|Proteobacteria,1T1RJ@1236|Gammaproteobacteria,2Q8RU@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component	cysJ	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009337,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0032991,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	iECO26_1355.ECO26_3835,iECSE_1348.ECSE_3020,iECW_1372.ECW_m2972,iEKO11_1354.EKO11_1004,iEcE24377_1341.EcE24377A_3066,iEcolC_1368.EcolC_0948,iWFL_1372.ECW_m2972	FAD_binding_1,Flavodoxin_1,NAD_binding_1
k141_334_1	1500301.JQMF01000006_gene1760	1.71e-64	219.0	COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria,4BIH2@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	DNA polymerase A domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A
k141_2080_1	1121948.AUAC01000005_gene2074	7.5e-15	79.3	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
k141_1210_1	1101192.KB910516_gene2244	1.36e-86	275.0	28HD5@1|root,2Z7PV@2|Bacteria,1R46T@1224|Proteobacteria,2U0A1@28211|Alphaproteobacteria,1JSJ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
k141_1355_1	177439.DP2750	4.68e-105	328.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
k141_629_1	1322246.BN4_20136	8.84e-30	118.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2M807@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
k141_1641_1	1121403.AUCV01000015_gene4693	3.44e-61	208.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,2MIY7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
k141_192_1	177439.DP1317	5.96e-79	244.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MJHM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
k141_1502_1	1403313.AXBR01000002_gene4080	5.02e-08	50.8	2DMNG@1|root,32SP1@2|Bacteria,1VAXC@1239|Firmicutes,4HM1Q@91061|Bacilli,1ZI92@1386|Bacillus	91061|Bacilli	S	COG NOG14552 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_631_1	187272.Mlg_2286	5.97e-66	222.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k141_2227_1	1219077.VAZ01S_050_00460	4.21e-12	72.0	COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XSBS@135623|Vibrionales	135623|Vibrionales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,VWA_2
k141_1642_1	1150469.RSPPHO_03277	4.54e-19	84.3	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
k141_1787_1	765914.ThisiDRAFT_0033	1.01e-65	213.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1WX6S@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
k141_1212_1	1198232.CYCME_2433	7.42e-11	58.2	2DDNE@1|root,2ZINX@2|Bacteria,1PAK4@1224|Proteobacteria,1STKN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1212_2	765912.Thimo_2433	1.09e-34	120.0	COG3450@1|root,COG3450@2|Bacteria,1N8CD@1224|Proteobacteria,1SAR6@1236|Gammaproteobacteria,1X27X@135613|Chromatiales	135613|Chromatiales	S	enzyme of the cupin superfamily	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
k141_338_1	756883.Halar_2608	1.81e-42	152.0	COG0114@1|root,arCOG01749@2157|Archaea	2157|Archaea	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0425	FumaraseC_C,Lyase_1
k141_338_2	765912.Thimo_1468	1.15e-22	96.3	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales	135613|Chromatiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
k141_1213_1	391615.ABSJ01000022_gene299	4.46e-72	231.0	COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1J4JD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
k141_1066_1	1219080.VEZ01S_01_00430	1.18e-12	70.9	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,1XV3J@135623|Vibrionales	135623|Vibrionales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
k141_777_1	1480694.DC28_09715	3.43e-09	58.9	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2J5K8@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
k141_1643_1	983328.AFGH01000002_gene1289	2.15e-07	47.8	2AK5G@1|root,31AVC@2|Bacteria,1Q693@1224|Proteobacteria,432NC@68525|delta/epsilon subdivisions,2YSJH@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1358_1	349521.HCH_02592	6.79e-53	192.0	COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,1XN5T@135619|Oceanospirillales	135619|Oceanospirillales	E	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
k141_633_1	1144310.PMI07_003356	1.04e-52	184.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria,4B77J@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
k141_339_1	118168.MC7420_2351	4.56e-32	119.0	COG1861@1|root,COG1861@2|Bacteria,1G3T7@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
k141_1788_1	1499967.BAYZ01000026_gene1558	9e-164	479.0	COG0376@1|root,COG0376@2|Bacteria,2NQNQ@2323|unclassified Bacteria	2|Bacteria	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
k141_1359_1	566466.NOR53_2965	8.11e-86	283.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1SJIP@1236|Gammaproteobacteria,1J8PH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
k141_779_1	1221522.B723_28940	1.1e-38	142.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1YMYY@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
k141_340_1	83406.HDN1F_38000	4.8e-08	55.1	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	ATP-synt_A
k141_340_2	1323663.AROI01000002_gene1093	1.58e-14	72.0	COG3312@1|root,COG3312@2|Bacteria,1N777@1224|Proteobacteria,1SD0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	atp synthase	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
k141_1645_1	246200.SPO3650	2.05e-23	103.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4NBBC@97050|Ruegeria	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16
k141_1068_1	472759.Nhal_1612	2.25e-58	206.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales	135613|Chromatiales	F	Ribonucleotide reductase, barrel domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
k141_61_1	713587.THITH_02875	7.07e-90	281.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
k141_494_1	657309.BXY_20230	3.49e-11	68.2	COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,2FP3B@200643|Bacteroidia,4AMRR@815|Bacteroidaceae	976|Bacteroidetes	D	Tyrosine recombinase XerC	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
k141_198_1	1044.EH31_13080	4.65e-94	290.0	COG3291@1|root,COG5297@1|root,COG3291@2|Bacteria,COG5297@2|Bacteria,1Q444@1224|Proteobacteria,2TW3J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase2,F5_F8_type_C
k141_927_1	626887.J057_16745	1.16e-29	120.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
k141_341_1	1439940.BAY1663_02740	1.93e-59	193.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RSHU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
k141_341_2	266264.Rmet_5542	5.46e-12	62.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2VSJA@28216|Betaproteobacteria,1K8EV@119060|Burkholderiaceae	28216|Betaproteobacteria	L	transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
k141_1508_1	522306.CAP2UW1_0140	9.56e-55	189.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_1646_1	536019.Mesop_3793	2.18e-120	351.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,43NKE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
k141_928_1	859653.HIMB5_00009010	4.21e-09	58.5	COG1035@1|root,COG1035@2|Bacteria,1R45V@1224|Proteobacteria,2U2DM@28211|Alphaproteobacteria,4BREZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Coenzyme F420 hydrogenase dehydrogenase, beta subunit C terminus	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
k141_928_2	388739.RSK20926_17107	8.57e-34	125.0	COG3000@1|root,COG3000@2|Bacteria,1NXAF@1224|Proteobacteria,2U1E6@28211|Alphaproteobacteria,2P106@2433|Roseobacter	28211|Alphaproteobacteria	I	COG3000 Sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
k141_1509_1	349124.Hhal_2379	1.07e-05	52.8	2DT83@1|root,33J44@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_199_1	593907.Celgi_2622	2.49e-36	141.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
k141_199_2	1120950.KB892755_gene5966	4.25e-05	44.7	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4DPD1@85009|Propionibacteriales	201174|Actinobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
k141_1793_1	438753.AZC_3598	1.63e-43	158.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT52@1224|Proteobacteria,2TVNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Toprim-like	-	-	3.6.4.12	ko:K17680	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	DnaB_C,Toprim_2
k141_1946_1	290317.Cpha266_1774	3.18e-147	433.0	COG0513@1|root,COG0513@2|Bacteria,1FEU1@1090|Chlorobi	1090|Chlorobi	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
k141_540_1	314278.NB231_09623	4.64e-45	157.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1T3U5@1236|Gammaproteobacteria,1X1MF@135613|Chromatiales	135613|Chromatiales	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp
k141_971_1	1121405.dsmv_1436	1.24e-132	391.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
k141_832_1	1380394.JADL01000001_gene2880	3.24e-37	137.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,2JRG4@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
k141_245_1	867845.KI911784_gene2655	4.33e-28	117.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2G68T@200795|Chloroflexi,375B4@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
k141_541_1	506534.Rhein_3191	0.000326	46.6	2BN8J@1|root,32GW0@2|Bacteria,1RH74@1224|Proteobacteria,1S7A4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
k141_682_1	754477.Q7C_1903	5.08e-42	141.0	2D5VR@1|root,32TJX@2|Bacteria,1RJJR@1224|Proteobacteria,1SA2M@1236|Gammaproteobacteria,46308@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_682_2	1034347.CAHJ01000050_gene433	9.03e-13	65.9	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,4HKYT@91061|Bacilli,1ZGXI@1386|Bacillus	91061|Bacilli	K	transcriptional	czrA	-	-	ko:K22043	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
k141_682_3	28229.ND2E_1100	1.19e-20	88.6	2E2R2@1|root,32XTN@2|Bacteria,1NHQU@1224|Proteobacteria,1SBJ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
k141_1556_1	484018.BACPLE_00673	2.07e-16	78.6	COG2963@1|root,COG2963@2|Bacteria,4NTDV@976|Bacteroidetes,2FU37@200643|Bacteroidia,4ASJI@815|Bacteroidaceae	976|Bacteroidetes	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
k141_1556_2	1166948.JPZL01000002_gene1839	2.92e-19	86.7	COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,1RY0J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k141_291_1	1121878.AUGL01000002_gene2311	3.53e-61	210.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
k141_291_2	1044.EH31_10365	9.52e-48	171.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2KCZ7@204457|Sphingomonadales	204457|Sphingomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_1738_1	1464048.JNZS01000042_gene945	1.95e-11	69.3	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4D8NT@85008|Micromonosporales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
k141_726_1	871963.Desdi_3179	7.62e-25	108.0	COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,2492T@186801|Clostridia,262BK@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_147_1	1265505.ATUG01000003_gene347	2.42e-83	269.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MIG4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
k141_2026_1	990285.RGCCGE502_15855	2.95e-68	221.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,2U12R@28211|Alphaproteobacteria,4BAD3@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
k141_582_1	797304.Natgr_1613	6.54e-11	66.2	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,23T5J@183963|Halobacteria	183963|Halobacteria	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	argC	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
k141_292_1	1056820.KB900629_gene1620	8.22e-34	127.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,2PMV8@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	Alanine-glyoxylate amino-transferase	dapC	-	2.6.1.17	ko:K14261,ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
k141_1739_1	1260251.SPISAL_03110	2.68e-124	364.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
k141_293_1	312309.VF_A0258	4.44e-52	180.0	COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria,1XVVD@135623|Vibrionales	135623|Vibrionales	K	Protein of unknown function (DUF3612)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3612,HTH_3,Peptidase_M78
k141_148_1	1089439.KB902274_gene1892	2.86e-110	329.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,45ZMT@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
k141_1596_1	519989.ECTPHS_08483	8.29e-84	260.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
k141_1163_2	1313421.JHBV01000046_gene296	7.35e-18	86.7	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Peptidase_M28
k141_875_1	1232683.ADIMK_2022	1.08e-33	125.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,464U6@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,GSDH
k141_875_2	1026882.MAMP_02446	2.05e-18	77.8	2EGSV@1|root,33AIZ@2|Bacteria	2|Bacteria	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
k141_584_1	1265505.ATUG01000002_gene2293	4.82e-62	198.0	COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,42VV4@68525|delta/epsilon subdivisions,2WRNK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
k141_1455_1	391615.ABSJ01000034_gene1093	1.6e-68	215.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1J4ZD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Ubie_methyltran
k141_2029_1	614083.AWQR01000009_gene534	5.73e-95	289.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2VNI2@28216|Betaproteobacteria,4A9Y0@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
k141_1309_1	1144312.PMI09_02044	5.92e-74	231.0	COG3391@1|root,COG3391@2|Bacteria,1RERQ@1224|Proteobacteria,2U0ZW@28211|Alphaproteobacteria,4BP36@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Low-density lipoprotein-receptor YWTD domain	-	-	-	-	-	-	-	-	-	-	-	-	Ldl_recept_b
k141_441_1	448385.sce3730	1.64e-73	238.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2YXEU@29|Myxococcales	28221|Deltaproteobacteria	H	acetolactate synthase	-	-	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
k141_1164_1	102129.Lepto7375DRAFT_6340	3.56e-67	219.0	COG3464@1|root,COG3464@2|Bacteria,1G6BF@1117|Cyanobacteria,1HFBN@1150|Oscillatoriales	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_876_1	511.JT27_17445	3.42e-99	301.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,3T219@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
k141_295_2	1121101.HMPREF1532_00437	2.51e-06	49.3	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,2FN75@200643|Bacteroidia,4AK9V@815|Bacteroidaceae	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
k141_1742_1	440250.A5HL26_9CAUD	1e-19	92.4	4QBD3@10239|Viruses,4QXFU@35237|dsDNA viruses  no RNA stage,4QQ7Z@28883|Caudovirales,4QNJ0@10744|Podoviridae	10744|Podoviridae	S	P22 coat protein - gene protein 5	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0008150,GO:0009987,GO:0016032,GO:0016043,GO:0019012,GO:0019028,GO:0019030,GO:0019058,GO:0019068,GO:0019069,GO:0019075,GO:0022607,GO:0039620,GO:0042802,GO:0042803,GO:0044085,GO:0044403,GO:0044419,GO:0044423,GO:0046729,GO:0046797,GO:0046983,GO:0051704,GO:0071840	-	-	-	-	-	-	-	-	-	-	-
k141_2030_1	290397.Adeh_2071	5.69e-69	225.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2YW7U@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the alpha-IPM synthase homocitrate synthase family	cimA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
k141_442_1	522306.CAP2UW1_1750	8.89e-99	293.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
k141_585_1	1123257.AUFV01000007_gene217	2.78e-70	225.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k141_585_2	1216007.AOPM01000024_gene3001	8.1e-20	87.8	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,2Q1GS@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
k141_1887_1	7070.TC010249-PA	2.2e-46	167.0	2CQJ9@1|root,2R501@2759|Eukaryota,39VPP@33154|Opisthokonta,3BH26@33208|Metazoa,3D1HX@33213|Bilateria,41ZNG@6656|Arthropoda,3SQT2@50557|Insecta	33208|Metazoa	S	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1599_2	1279017.AQYJ01000024_gene1060	5.42e-44	145.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,466GF@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
k141_878_1	765914.ThisiDRAFT_1463	2.73e-56	186.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
k141_878_2	395019.Bmul_2700	1.96e-21	92.8	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,1JZQB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,S4_2,tRNA-synt_1b
k141_1459_1	373994.Riv7116_5269	8.71e-32	127.0	COG0018@1|root,COG0018@2|Bacteria,1G15V@1117|Cyanobacteria,1HKCG@1161|Nostocales	1117|Cyanobacteria	J	TIGRFAM Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
k141_152_1	1121440.AUMA01000009_gene593	1.33e-57	203.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2M832@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
k141_731_1	1313421.JHBV01000176_gene854	2.92e-05	45.8	2DPX5@1|root,333S8@2|Bacteria,4NXW9@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1889_1	641107.CDLVIII_1329	5.88e-08	58.2	COG4974@1|root,COG4974@2|Bacteria,1TQXV@1239|Firmicutes,24884@186801|Clostridia,36HA0@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
k141_445_2	236097.ADG881_178	1.41e-19	83.2	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XJJ8@135619|Oceanospirillales	135619|Oceanospirillales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
k141_1022_1	1187848.AJYQ01000089_gene2720	1.57e-21	86.7	2DMNG@1|root,32SP1@2|Bacteria,1NAN7@1224|Proteobacteria,1SCJK@1236|Gammaproteobacteria,1XYIM@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1460_1	768671.ThimaDRAFT_3018	7.65e-68	220.0	COG2801@1|root,COG2801@2|Bacteria,1MUSB@1224|Proteobacteria,1RYKV@1236|Gammaproteobacteria,1X06D@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	rve
k141_2179_1	760192.Halhy_6848	2.62e-32	129.0	COG4932@1|root,COG4932@2|Bacteria,4NKIK@976|Bacteroidetes	976|Bacteroidetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1166_1	1167006.UWK_02791	4.11e-96	301.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k141_879_1	1121875.KB907549_gene2005	3.49e-97	306.0	COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,1I0UR@117743|Flavobacteriia	976|Bacteroidetes	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.1.83	ko:K00656,ko:K18427	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
k141_1890_1	1121403.AUCV01000027_gene2478	1.48e-71	238.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WJ6F@28221|Deltaproteobacteria,2MN2N@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PTS HPr component phosphorylation site	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1,PTS_EIIA_2
k141_587_1	87626.PTD2_09983	3.1e-70	239.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q0SH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	HAMP domain GGDEF domain EAL	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_9,dCache_3
k141_1167_1	391603.FBALC1_10602	1.3e-108	318.0	COG3612@1|root,COG3612@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
k141_1023_1	1163408.UU9_02124	1.56e-36	139.0	COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1X37V@135614|Xanthomonadales	135614|Xanthomonadales	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
k141_732_1	1335757.SPICUR_08290	1.25e-18	84.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_732_2	1279017.AQYJ01000019_gene1445	1.89e-106	317.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,4651Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_1747_1	443152.MDG893_00145	1.38e-94	282.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria,465MQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG1126 ABC-type polar amino acid transport system, ATPase component	yhdZ	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21	ko:K02028,ko:K02029,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	iJN746.PP_1300	ABC_tran
k141_1601_1	1346791.M529_07670	2.6e-22	99.4	COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,2TRCG@28211|Alphaproteobacteria,2K0ND@204457|Sphingomonadales	204457|Sphingomonadales	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_1601_2	574966.KB898651_gene2055	9.32e-05	45.1	COG1737@1|root,COG1737@2|Bacteria,1MW2B@1224|Proteobacteria,1RS6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
k141_11_1	1500897.JQNA01000001_gene5784	3.31e-29	114.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,1K4YM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
k141_300_1	344747.PM8797T_26935	2.76e-33	131.0	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_1462_1	1123034.JMKP01000004_gene1713	4.13e-09	55.8	COG0695@1|root,COG0695@2|Bacteria,1N6ZT@1224|Proteobacteria,1SD1U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutaredoxin	nrdH	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
k141_1462_2	697282.Mettu_0212	2.1e-31	117.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1XFGU@135618|Methylococcales	135618|Methylococcales	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
k141_423_1	31234.CRE17459	3.61e-133	432.0	2CN0N@1|root,2QT5H@2759|Eukaryota,38HD6@33154|Opisthokonta,3BNTW@33208|Metazoa,3D1YD@33213|Bilateria,40IET@6231|Nematoda,1M1Q3@119089|Chromadorea,40UDH@6236|Rhabditida	33208|Metazoa	S	nucleic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2,Endonuclease_7
k141_1014_1	1502851.FG93_01999	2.66e-20	90.5	COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
k141_1014_2	1185652.USDA257_c32470	2.5e-49	167.0	COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,2TR7C@28211|Alphaproteobacteria,4B850@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
k141_1303_1	1249627.D779_4113	3.95e-90	295.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
k141_425_1	235985.BBPN01000001_gene1388	2.59e-55	195.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,2NECJ@228398|Streptacidiphilus	201174|Actinobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
k141_428_1	768671.ThimaDRAFT_4355	1.67e-65	219.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,1SKFJ@1236|Gammaproteobacteria,1X099@135613|Chromatiales	135613|Chromatiales	L	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
k141_433_1	314287.GB2207_05749	1.82e-57	181.0	2E2R2@1|root,32XTN@2|Bacteria,1NHQU@1224|Proteobacteria,1SBJ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
k141_434_1	29495.EA26_11600	6.65e-22	96.3	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1XTEI@135623|Vibrionales	135623|Vibrionales	O	Zn-dependent protease with chaperone function	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
k141_1803_1	1121374.KB891575_gene794	1.85e-61	204.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
k141_385_1	565045.NOR51B_2425	1.74e-59	203.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1J9C4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
k141_1995_1	1313172.YM304_08160	6.25e-108	321.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia	84992|Acidimicrobiia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
k141_1265_1	243233.MCA1740	1.67e-89	274.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XDU5@135618|Methylococcales	135618|Methylococcales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.9	ko:K14067	ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200	M00346	R01256	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
k141_386_1	314287.GB2207_07537	3.01e-98	306.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit	scpA	GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004	B12-binding,MM_CoA_mutase
k141_110_1	1408422.JHYF01000021_gene983	2.41e-46	168.0	COG4626@1|root,COG4626@2|Bacteria,1TPU1@1239|Firmicutes,248RI@186801|Clostridia,36E5Y@31979|Clostridiaceae	186801|Clostridia	S	Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
k141_543_1	296591.Bpro_3972	5.3e-63	204.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VME1@28216|Betaproteobacteria,4AB28@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_2
k141_1121_1	391615.ABSJ01000042_gene2284	2.66e-39	151.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	penicillin-binding protein	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
k141_1414_1	879212.DespoDRAFT_02520	2.57e-53	182.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
k141_111_1	990285.RGCCGE502_20275	8.26e-36	133.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,4B809@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
k141_1559_1	595460.RRSWK_07151	3.69e-46	160.0	COG4948@1|root,COG4948@2|Bacteria,2IY85@203682|Planctomycetes	203682|Planctomycetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.171	ko:K21624	ko00330,map00330	-	R11625	-	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
k141_975_1	981223.AIED01000006_gene3491	1.68e-13	74.7	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,3NJHZ@468|Moraxellaceae	1236|Gammaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
k141_249_1	1488328.JMCL01000078_gene3046	2.1e-13	75.1	COG1028@1|root,COG1028@2|Bacteria,1R5B1@1224|Proteobacteria,1SZN9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
k141_1998_1	644282.Deba_2842	2.56e-62	212.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
k141_1699_1	595537.Varpa_2142	9.08e-41	146.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2VM3U@28216|Betaproteobacteria,4ABJX@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
k141_1560_1	521674.Plim_4138	1.01e-32	125.0	COG3119@1|root,COG3119@2|Bacteria,2IX1H@203682|Planctomycetes	203682|Planctomycetes	P	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
k141_1560_2	1123072.AUDH01000002_gene2432	2.33e-13	69.7	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,2JR4Z@204441|Rhodospirillales	204441|Rhodospirillales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
k141_112_1	1134474.O59_003522	1.76e-50	164.0	COG0824@1|root,COG0824@2|Bacteria,1QSV7@1224|Proteobacteria,1RWFU@1236|Gammaproteobacteria,1FI96@10|Cellvibrio	1236|Gammaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
k141_976_1	269797.Mbar_A1810	2.4e-08	53.5	COG0071@1|root,arCOG01838@2157|Archaea	2157|Archaea	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
k141_251_1	1116472.MGMO_122c00040	1.18e-83	274.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1XDZM@135618|Methylococcales	135618|Methylococcales	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
k141_252_1	631362.Thi970DRAFT_03536	1.04e-106	340.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales	135613|Chromatiales	E	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
k141_1125_1	84588.SYNW0985	1.01e-24	108.0	COG2931@1|root,COG3209@1|root,COG3898@1|root,COG5625@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3898@2|Bacteria,COG5625@2|Bacteria,1GJ0A@1117|Cyanobacteria,1H18T@1129|Synechococcus	1117|Cyanobacteria	Q	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
k141_1418_1	1168065.DOK_13329	1.4e-47	162.0	COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,1RY3J@1236|Gammaproteobacteria,1J68V@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_115_1	247639.MGP2080_01861	4.6e-46	167.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1J4FA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_840_1	1380356.JNIK01000021_gene4578	4.32e-26	112.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
k141_1126_1	1282876.BAOK01000001_gene3578	1.53e-59	197.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TW0G@28211|Alphaproteobacteria,4BTG2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2,Reductase_C,Rieske
k141_253_1	985054.JQEZ01000001_gene2841	2.42e-96	290.0	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,4NA5U@97050|Ruegeria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	opuAA	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
k141_690_1	1278307.KB906974_gene1806	1.45e-73	247.0	COG0642@1|root,COG0834@1|root,COG4251@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QIRM@267894|Psychromonadaceae	1236|Gammaproteobacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	CHASE,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
k141_1703_1	1123057.P872_04760	2.02e-36	141.0	COG3291@1|root,COG5498@1|root,COG3291@2|Bacteria,COG5498@2|Bacteria,4PPR2@976|Bacteroidetes,47YQN@768503|Cytophagia	976|Bacteroidetes	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_393_1	255470.cbdbA146	1.5e-40	145.0	COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi,34CSP@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	-	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
k141_1563_1	765913.ThidrDRAFT_1840	2.95e-225	626.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RQDY@1236|Gammaproteobacteria,1WXVM@135613|Chromatiales	135613|Chromatiales	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
k141_1127_1	1279038.KB907344_gene3551	6.13e-91	275.0	COG0444@1|root,COG0444@2|Bacteria,1NTNP@1224|Proteobacteria,2TUKU@28211|Alphaproteobacteria,2JQ6X@204441|Rhodospirillales	204441|Rhodospirillales	EP	ATPases associated with a variety of cellular activities	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran
k141_1850_1	1121924.ATWH01000025_gene1350	1.39e-10	68.2	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4FMGG@85023|Microbacteriaceae	201174|Actinobacteria	KLT	PASTA	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
k141_254_1	935261.JAGL01000004_gene864	5.63e-70	223.0	COG0179@1|root,COG0179@2|Bacteria,1NTUI@1224|Proteobacteria,2U2F5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
k141_1272_1	983545.Glaag_1317	4.76e-100	301.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,464KB@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
k141_1564_1	1286106.MPL1_06889	2.32e-93	286.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,45ZRY@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
k141_842_1	1122599.AUGR01000005_gene1860	2.04e-74	248.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
k141_2004_1	671143.DAMO_1264	3.66e-49	176.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
k141_981_1	998674.ATTE01000001_gene480	6.07e-15	79.3	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,46048@72273|Thiotrichales	72273|Thiotrichales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
k141_2156_1	1296415.JACC01000010_gene2073	6.94e-09	62.4	COG1361@1|root,COG2885@1|root,COG2911@1|root,COG3291@1|root,COG1361@2|Bacteria,COG2885@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,4NPJI@976|Bacteroidetes,1I2IK@117743|Flavobacteriia,2YI1G@290174|Aquimarina	976|Bacteroidetes	M	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1421_1	998674.ATTE01000001_gene4328	3.98e-38	130.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,461GC@72273|Thiotrichales	72273|Thiotrichales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
k141_1421_2	2340.JV46_04110	1.02e-46	151.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1J6FZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016530,GO:0019538,GO:0022607,GO:0031163,GO:0034986,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0140104,GO:1901564	-	ko:K05997,ko:K13628	-	-	-	-	ko00000,ko03016	-	-	iAPECO1_1312.APECO1_3997,iB21_1397.B21_02384,iBWG_1329.BWG_2292,iE2348C_1286.E2348C_2811,iEC042_1314.EC042_2732,iEC55989_1330.EC55989_2813,iECABU_c1320.ECABU_c28340,iECBD_1354.ECBD_1156,iECB_1328.ECB_02420,iECDH10B_1368.ECDH10B_2695,iECD_1391.ECD_02420,iECED1_1282.ECED1_2959,iECIAI1_1343.ECIAI1_2580,iECIAI39_1322.ECIAI39_2729,iECNA114_1301.ECNA114_2607,iECO103_1326.ECO103_3045,iECO111_1330.ECO111_3252,iECO26_1355.ECO26_3575,iECOK1_1307.ECOK1_2877,iECP_1309.ECP_2533,iECS88_1305.ECS88_2704,iECSE_1348.ECSE_2814,iECSF_1327.ECSF_2372,iECSP_1301.ECSP_3472,iECUMN_1333.ECUMN_2848,iECW_1372.ECW_m2754,iECs_1301.ECs3394,iEKO11_1354.EKO11_1205,iETEC_1333.ETEC_2685,iEcDH1_1363.EcDH1_1140,iEcSMS35_1347.EcSMS35_2681,iEcolC_1368.EcolC_1149,iG2583_1286.G2583_3058,iJO1366.b2528,iLF82_1304.LF82_1120,iNRG857_1313.NRG857_12580,iSBO_1134.SBO_2552,iSDY_1059.SDY_2724,iSF_1195.SF2575,iSSON_1240.SSON_2610,iS_1188.S2747,iUMN146_1321.UM146_04060,iUMNK88_1353.UMNK88_3181,iWFL_1372.ECW_m2754,iY75_1357.Y75_RS13195,iZ_1308.Z3795,ic_1306.c3053	Fe-S_biosyn
k141_843_2	1121875.KB907548_gene1605	2.45e-15	78.6	28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,1HZDQ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
k141_1129_1	1163617.SCD_n02491	2.15e-66	219.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
k141_256_1	187272.Mlg_0458	3.02e-77	236.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1WVZS@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
k141_1852_1	85643.Tmz1t_0616	3.18e-102	306.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2VMMF@28216|Betaproteobacteria,2KV9B@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
k141_983_1	1294273.roselon_02752	2.21e-94	289.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
k141_396_1	225849.swp_1281	7.08e-18	85.1	COG0330@1|root,COG0330@2|Bacteria,1PRSV@1224|Proteobacteria,1TK9U@1236|Gammaproteobacteria,2QACD@267890|Shewanellaceae	1236|Gammaproteobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
k141_396_2	509635.N824_16215	3.85e-08	57.8	COG2085@1|root,COG2085@2|Bacteria,4NEC7@976|Bacteroidetes,1IUJA@117747|Sphingobacteriia	976|Bacteroidetes	S	Shikimate / quinate 5-dehydrogenase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
k141_1437_1	1123401.JHYQ01000007_gene527	1.45e-60	195.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,4604G@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
k141_1437_2	7213.XP_004532339.1	8.8e-41	151.0	COG0021@1|root,COG0057@1|root,COG0126@1|root,KOG0523@2759|Eukaryota,KOG0657@2759|Eukaryota,KOG1367@2759|Eukaryota,38EF9@33154|Opisthokonta,3BE59@33208|Metazoa,3CT3V@33213|Bilateria,41WKZ@6656|Arthropoda,3SGSE@50557|Insecta,450G1@7147|Diptera	33208|Metazoa	G	Phosphoglycerate kinase activity. It is involved in the biological process described with glycolytic process	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
k141_1290_1	395493.BegalDRAFT_2678	4.2e-38	146.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,45ZVF@72273|Thiotrichales	72273|Thiotrichales	NU	Type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
k141_412_1	220341.16506051	2.36e-39	145.0	COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1S8D6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
k141_1868_1	382245.ASA_3514	5.58e-49	169.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,1RNVN@1236|Gammaproteobacteria,1Y55V@135624|Aeromonadales	135624|Aeromonadales	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
k141_1868_2	1288494.EBAPG3_14900	5.77e-51	169.0	COG1136@1|root,COG1136@2|Bacteria,1QU8Q@1224|Proteobacteria,2WGJ2@28216|Betaproteobacteria	28216|Betaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
k141_1723_1	1469245.JFBG01000078_gene308	3.81e-74	244.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales	135613|Chromatiales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
k141_136_2	331678.Cphamn1_1568	1.69e-66	212.0	COG1932@1|root,COG1932@2|Bacteria	2|Bacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Aminotran_5
k141_413_1	870187.Thini_4377	5.13e-36	139.0	COG0500@1|root,COG0534@1|root,COG0500@2|Bacteria,COG0534@2|Bacteria,1RDRV@1224|Proteobacteria,1S2T5@1236|Gammaproteobacteria,460JX@72273|Thiotrichales	72273|Thiotrichales	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
## 763 queries scanned
## Total time (seconds): 41.827353715896606
## Rate: 18.24 q/s